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Poly-l-lactic acid skin

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https://www.readbyqxmd.com/read/29607627/safety-and-complications-of-absorbable-threads-made-of-poly-l-lactic-acid-and-poly-lactide-glycolide-experience-with-148-consecutive-patients
#1
Sukran Sarigul Guduk, Nezih Karaca
BACKGROUND: Thread lifting is a minimally invasive procedure for lifting and repositioning tissues. Few articles with absorbable sutures exist in the literature. Furthermore there is no study focusing on complications of absorbable sutures. OBJECTIVE: To describe complications of thread lifting using a totally absorbable suture composed of poly-L-lactic acid affixed with poly lactide/glycolide cones. METHODS: Data regarding complications were analyzed retrospectively for 148 patients underwent thread lifting between June 2014 and February 2017...
April 1, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29510800/microneedles-as-enhancer-of-drug-absorption-through-the-skin-and-applications-in-medicine-and-cosmetology
#2
Pablo Serrano-Castañeda, Jose Juan Escobar-Chavez, Isabel Marlen Rodriguez-Cruz, Luz Maria Melgoza, Jessica Martinez-Hernandez
The microneedles technology has found applications in many health-related fields. For example, their application in drugs and vaccines delivery as well, as the determination of biomarkers, has been reported. They also have a place in the dermatology and cosmetic areas such as the treatment of wounds from burns, scars, acne, depigmentation, and alopecia will be shown. Microneedles are used in therapeutic applications and are manufactured using materials such as metal (steel, titanium, nickel), polymer (oly-glycolic acid (PGA), poly-lactide-co-glycolide acid (PLGA), poly-L-lactic acid (PLA), chitosan), glass, silicon, ceramic, carbohydrates (trehalose, sucrose, mannitol)...
2018: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29462686/plga-nanoformulation-of-sparfloxacin-enhanced-antibacterial-activity-with-photoprotective-potential-under-ambient-uv-r-exposure
#3
Jyoti Singh, Ashish Dwivedi, Lipika Ray, Deepti Chopra, Divya Dubey, Ajeet K Srivastva, Smita Kumari, Randhir Kumar Yadav, Saroj Kumar Amar, Chandana Haldar, Ratan Singh Ray
Sparfloxacin (SPFX) is a broad spectrum antibiotic which inhibits bacterial DNA gyrase enzyme activity. However, photodegradation in the presence of UVA limits its antibacterial activity and induces phototoxicity. Thus, to encounter this problem, we have developed poly d,l-lactic-co-glycolic acid (PLGA) loaded SPFX nanoparticles. Here, we have performed a comparative antibacterial activity of SPFX and its nanoparticles (NPs) through molecular docking and plate sensitivity assay. Under environmental UVA exposure, photoexcited SPFX significantly generates ROS, DNA damage and mitochondrial mediated cell death in comparison to PLGA-SPFX-NPs (nano SPFX) in human skin cell line (HaCaT)...
April 25, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29461124/improving-mandibular-contour-a-pilot-study-for-indication-of-ppla-traction-thread-use
#4
Stefania Guida, Flavia Persechino, Giuseppe Rubino, Giovanni Pellacani, Francesca Farnetani, Giacomo Giovanni Urtis
BACKGROUND: The request for less-aggressive procedures to improve mandibular contour is increasing. Several kinds of threads have been used for this purpose. Nevertheless, PLLA (poly-L-Lactic acid) traction thread procedure has not been previously described. AIM: To investigate the role of PLLA traction threads in improving mandibular contour. METHODS: Twenty women were enrolled in the study. They were differentially classified for skin laxity...
February 20, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29247316/development-of-transdermal-vitamin-d3-vd3-delivery-system-using-combinations-of-plga-nanoparticles-and-microneedles
#5
Hye-Gyeong Kim, Deborah L Gater, Yeu-Chun Kim
Although vitamin D3 (VD3), which is the main form of vitamin D, can be produced in human skin under the sunlight, vitamin D deficiency emerged as a major public health problem worldwide. Mainly, oral supplements or vitamin D-fortified foods are distributed to help supplementation of vitamin D. However, those oral methods are limitedly supplied in the Middle East countries, and oral absorption has low efficiency due to many barriers and various changes of conditions along the route. Then, it is recommended to take them every day in order to maintain the adequate serum level of vitamin D...
February 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29232107/2d-material-based-nanofibrous-membrane-for-photothermal-cancer-therapy
#6
Jundong Shao, Hanhan Xie, Huaiyu Wang, Wenhua Zhou, Qian Luo, Xue-Feng Yu, Paul K Chu
One of the clinical challenges facing photothermal cancer therapy is health risks imposed by the photothermal nanoagents in vivo. Herein, a photothermal therapy (PTT) platform composed of a 2D material-based nanofibrous membrane as the agent to deliver thermal energy to tumors under near-infrared (NIR) light irradiation is described. The photothermal membrane, which is fabricated by an electrospinning poly(l-lactic acid) (PLLA) nanofibrous membrane loaded with bismuth selenide (Bi2 Se3 ) nanoplates, exhibits very high photothermal conversion efficiency and long-term stability...
January 10, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29119683/poly-l-lactic-acid-for-the-improvement-of-photodamage-and-rhytids-of-the-d%C3%A3-colletage
#7
Eric C Wilkerson, David J Goldberg
BACKGROUND: Poly-L-lactic acid (PLLA) is a biostimulatory filler approved for use in HIV lipoatrophy as well as cosmetic improvement in facial folds and wrinkles in immunocompetent patients. Similar to the face and hands, the décolletage is commonly subject to photodamage and the resulting appearance of rhytids and crepiness, which could benefit from PLLA treatment. OBJECTIVES: The objective of the study was to assess the safety and efficacy of injected PLLA for the improvement in rhytids and crepiness of the décolletage...
November 8, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28992774/treatment-of-a-burn-animal-model-with-functionalized-tridimensional-electrospun-biomaterials
#8
Daniela Steffens, Monica Beatriz Mathor, Paula Rigon da Luz Soster, Gustavo Vergani, Dayane Piffer Luco, Patricia Pranke
Laminin-functionalized poly-d,l-lactic acid scaffolds were produced. Following this, mesenchymal stem cells and keratinocytes were seeded on biomaterials for the in vivo experiments, where the biomaterials with or without cells were implanted. The analysis is comprised of the visual aspect and mean size of the lesion plus the histology and gene expression. The results showed that the cells occupied all the structure of the scaffolds in all the groups. After nine days of in vivo experiments, the defect size did not show statistical difference among the groups, although the groups with the poly-d,l-lactic acid/Lam biomaterial had the lowest lesion size and presented the best visual aspect of the wound...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28864389/antibiotic-incorporation-in-jet-sprayed-nanofibrillar-biodegradable-scaffolds-for-wound-healing
#9
Maxime Dzikowski, Naomi Castanié, Amélie Guedon, Bernard Verrier, Charlotte Primard, Jérôme Sohier
In view of preparing antibiotic-loaded structures that can be used as dressing to prevent or contain wound infections, this study evaluates biodegradable nanofibrillar matrices obtained by jet-spraying and containing ciprofloxacin (CIF). The matrices were prepared from different blends of poly-(ε-caprolactone) (PCL) and poly-d,l-(lactic acid) (PDLLA) in view of controlling mechanical properties, biodegradation and antibiotic release rate. The effect of CIF incorporation was assessed in regard of matrices fiber diameter, mechanical properties and degradation while antibiotic release from the polymer blends of different PCL/PDLLA ratios was measured in buffers of different pH to better mimic the wound context...
November 5, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28804684/bioresorbable-scaffold-as-a-dermal-substitute
#10
Lenon Cardoso, Marília Colturato Cleto, Maria Lourdes Peris Barbo, Andréa Rodrigues Esposito, Flavio Stillitano Orgaes, Eliana Aparecida de Rezende Duek
INTRODUCTION: Bioresorbable polymers are often used in medical procedures. Since they are biocompatible, this class of materials is a viable alternative for cases in which tissue regeneration is strongly compromised. Bioresorbable synthetic polymers may be used as membranes to support and guide cell growth through the process of tissue repair. OBJECTIVE: To assess the efficiency of a porous bioresorbable membrane Poly (L-co-DL lactic acid)-co-trimethylene carbonate, PL-co-DLA-co-TMC, as a dermal substitute associated with partial skin graft in rats...
2017: International Journal of Burns and Trauma
https://www.readbyqxmd.com/read/28707999/development-of-a-membrane-of-poly-l-co-d-l-lactic-acid-co-trimethylene-carbonate-with-aloe-vera-an-alternative-biomaterial-designed-to-improve-skin-healing
#11
Daniel Komatsu, Daniel V Mistura, Adriana Motta, Juliana A Domingues, Moema A Hausen, Eliana Duek
The search for new therapies and drugs that act as topical agents to relieve pain and control the infectious processes in burns always attracted interest in clinical trials. As an alternative to synthetic drugs, the use of natural extracts is useful in the development of new strategies and formulations for improving the life quality. The aim of this study was to develop a wound dressing using Poly(L-co-D,L lactic acid-co-TMC) (PLDLA-co-TMC) containing aloe vera (AV). This natural plant extract is known for its modulatory effects under healing process...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28621889/enhanced-skin-regeneration-by-herbal-extract-coated-poly-l-lactic-acid-nanofibrous-scaffold
#12
Aytak Jouybar, Ehsan Seyedjafari, Abdolreza Ardeshirylajimi, Ali Zandi-Karimi, Nikta Feizi, Mohammad-Mehdi Khani, Iraj Pousti
The wound healing process is directly related to the type of treatment. Existing methods of treatment are not responsive enough for severe wounds. The aim of this study was the potential capacity investigation of poly-L-lactic acid (PLLA) nanofibrous scaffolds coated by aloe vera gel for wound dressing applications. In this study, electrospinning method was used for preparing PLLA nanofibers, and after characterization by SEM and MTT, its influence on the wound healing process was investigated with and without aloe vera gel as a wound dressing in full-thickness skin defect in mice...
November 2017: Artificial Organs
https://www.readbyqxmd.com/read/28548695/development-of-a-novel-bioabsorbable-implant-that-is-substituted-by-adipose-tissue-in-vivo
#13
Shuichi Ogino, Naoki Morimoto, Michiharu Sakamoto, Chizuru Jinno, Katsuhiro Yoshikawa, Tatsuki Enoshiri, Yuki Sakamoto, Tsuguyoshi Taira, Shigehiko Suzuki
Recently, adipose tissue has been regenerated by combining scaffolds, growth factors, and/or adipose-tissue-derived stromal cells. However, the safety of growth factors and adipose-tissue-derived stromal cells has not been confirmed in cancer patients. We reported the regeneration of adipose tissue in the internal space of a polypropylene mesh containing a collagen sponge (CS), without using any growth factors or cells. We herein explored the formation of adipose tissue, using the bioabsorbable implant containing CS, in rats...
March 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28384029/controlled-dual-delivery-of-angiogenin-and-curcumin-by-electrospun-nanofibers-for-skin-regeneration
#14
Yunfei Mo, Rui Guo, Yi Zhang, Wei Xue, Biao Cheng, Yuanming Zhang
In this study, we successfully fabricated a novel drug and plasmid DNA (pDNA) dual delivery system by electrospinning the dispersion composed of polyethyleneimine-carboxymethyl chitosan/pDNA-angiogenin (ANG) nanoparticles, curcumin (Cur), poly (D, L-lactic-co-glycolic acid) (PLGA), and cellulose nanocrystals (CNCs). In vitro release studies showed that the bioactivity of Cur and ANG was preserved in the nanofibers, and a sequential release pattern was achieved in which nearly 90% of the Cur was released in ca...
March 27, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/27858218/bleomycin-coated-microneedles-for-treatment-of-warts
#15
Han Sol Lee, Ha Ryeong Ryu, Joo Young Roh, Jung-Hwan Park
PURPOSE: Bleomycin-coated microneedles were devised for delivery of bleomycin into the sub-epidermal skin layer for the treatment of warts in order to provide patient convenience and reduce patient pain and fear. METHOD: Poly-lactic-acid (L-PLA) microneedles were fabricated by a molding process and then the tips were partially coated using a dip-coating method based on a microstructure well. The mechanical strength of the pre-coated polymer microneedles was observed by inserting them in porcine foot and back skin...
January 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/27503270/composite-membranes-of-recombinant-silkworm-antimicrobial-peptide-and-poly-l-lactic-acid-plla-for-biomedical-application
#16
Zhi Li, Xuan Liu, Yi Li, Xiqian Lan, Polly Hangmei Leung, Jiashen Li, Gang Li, Maobin Xie, Yanxia Han, Xiaofen Lin
Antimicrobial peptides, produced by innate immune system of hosts in response to invading pathogens, are capable of fighting against a spectrum of bacteria, viruses, fungi, parasites and cancer cells. Here, a recombinant silkworm AMP Bmattacin2 from heterologous expression is studied, indicating a broad spectrum of antibacterial activity and showing selective killing ability towards skin and colon cancer cells over their normal cell counterparts. For the purpose of biomedical application, the electrospinning fabrication technique is employed to load Bmattacin2 into PLLA nanofibrous membrane...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27128235/three-dimensional-rejuvenation-of-the-d%C3%A3-colletage
#17
REVIEW
Jennifer D Peterson, Suzanne L Kilmer
BACKGROUND: Photodamaged skin of the chest is characterized by skin laxity, lines/wrinkles, hyperpigmentation, erythema, tactile roughness, atrophy, and telangiectasias. METHODS: A MEDLINE search was performed on combination treatments in chest rejuvenation, and the results are summarized. Practical applications for these combinations of procedures are discussed. RESULTS: Reports of injectable poly-L-lactic acid (PLLA), hyaluronic acid (HA), and chemical peels, along with lasers and light therapies such as intense pulsed light (IPL), vascular lasers, photodynamic therapy (PDT), nonablative fractionated lasers (NAFLs), ablative fractionated lasers (AFLs), and microfocused ultrasound (MFU) have been reported for chest rejuvenation...
May 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27080882/factorial-design-optimization-and-characterization-of-poly-lactic-acid-pla-nanoparticle-formation-for-the-delivery-of-grape-extracts
#18
Katherina Fernández, Javiera Aburto, Carlos von Plessing, Marlene Rockel, Estrella Aspé
Proanthocyanidins (PAs) extracted from grapes have several bioactive properties, giving them potential medical uses. However, PAs are unstable in the digestive tract and must be stabilized to allow oral administration, which can be accomplished by nanoencapsulation. In this study, PAs extracted from grape seed and skin were stabilized with poly-d,l-lactide (PLA) polymer by the emulsion-evaporation method. An experimental Box-Behnken design was implemented, evaluating the influence of three factors: sonication time (30-360s) for the emulsion formation, loading of grape extracts (5-20%) and concentration of stabilizing agent (polyvinyl alcohol, PVA: 1-3%)...
September 15, 2016: Food Chemistry
https://www.readbyqxmd.com/read/26936629/electrospun-polymeric-core-sheath-yarns-as-drug-eluting-surgical-sutures
#19
Smrithi Padmakumar, John Joseph, Madhuri Harsha Neppalli, Sumi Elizabeth Mathew, Shantikumar V Nair, Sahadev A Shankarappa, Deepthy Menon
Drug-coated sutures are widely used as delivery depots for antibiotics and anti-inflammatory drugs at surgical wound sites. Although drug-laden coating provides good localized drug concentration, variable loading efficiency and release kinetics limits its use. Alternatively, drug incorporation within suture matrices is hampered by the harsh fabrication conditions required for suture-strength enhancement. To circumvent these limitations, we fabricated mechanically robust electrospun core-sheath yarns as sutures, with a central poly-l-lactic acid core, and a drug-eluting poly-lactic-co-glycolic acid sheath...
March 23, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/26566571/hand-rejuvenation
#20
REVIEW
Farhaad R Riyaz, David Ozog
Aging of the hands results from both natural processes and chronic ultraviolet light exposure. Together, these cause textural and pigmentary changes, excess skin laxity, rhytides, and soft tissue atrophy that presents as prominent bones and tendons with easily visible veins. Many options are available for the reversal of these changes. Photoaging can be improved with chemical peels and light-based treatments (such as Q-switched lasers), resurfacing lasers, intense pulsed light, and photodynamic therapy. Soft tissue atrophy can be corrected with autologous fat, nonanimal stabilized hyaluronic acid, calcium hydroxylapatite, and poly-L lactic acid injections...
September 2015: Seminars in Cutaneous Medicine and Surgery
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