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https://www.readbyqxmd.com/read/29764739/maternal-obesity-alters-the-expression-of-embryonic-regulatory-transcripts-in-the-preimplantation-ovine-conceptus
#1
Sarah R McCoski, Rebecca K Poole, McCauley T Vailes, Alan D Ealy
The influence of exposure to overfeeding-induced maternal obesity around the time of conception on early embryogenesis was examined in the day 14 ovine conceptus. The relative abundance of FGFR2 and DNMT1 was influenced by maternal obesity status and conceptus sex, and the abundance of PPARG and PTGS2 transcripts was greater in male conceptuses regardless of the obesity status of the ewe. These observations demonstrated that short-term exposure to maternal obesity impacts early conceptus transcript patterning...
May 12, 2018: Reproductive Biology
https://www.readbyqxmd.com/read/29762540/the-role-of-peroxisome-proliferator-activated-receptors-and-their-transcriptional-coactivators-gene-variations-in-human-trainability-a-systematic-review
#2
REVIEW
Miroslav Petr, Petr Stastny, Adam Zajac, James J Tufano, Agnieszka Maciejewska-Skrendo
BACKGROUND: The peroxisome proliferator-activated receptors ( PPARA , PPARG , PPARD ) and their transcriptional coactivators' ( PPARGC1A , PPARGC1B ) gene polymorphisms have been associated with muscle morphology, oxygen uptake, power output and endurance performance. The purpose of this review is to determine whether the PPARs and/or their coactivators' polymorphisms can predict the training response to specific training stimuli. METHODS: In accordance with the Preferred Reporting Items for Systematic Reviews and Meta Analyses, a literature review has been run for a combination of PPARs and physical activity key words...
May 15, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29758201/dietary-vitamin-a-impacts-dna-methylation-patterns-of-adipogenesis-related-genes-in-suckling-rats
#3
A Arreguín, J Ribot, H Musinovic, J von Lintig, A Palou, M L Bonet
We previously showed that vitamin A supplementation in early life impacts white adipose tissue (WAT) biology. We here studied the vitamin's effects on DNA methylation of genes crucial for WAT cell development, determination and metabolism. CpG promoter methylation and mRNA expression of Pparg, Zfp423, Pcna, and Rbp4 was compared in inguinal WAT of 21-day-old rats supplemented during the suckling period with vehicle (controls) or an emulsion of vitamin A as retinyl ester (RE) or β-carotene (BC). The methylation profile of promoters was affected by vitamin A supplementation with pronounced differences between the RE and BC groups...
May 11, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29752313/schistosomiasis-induces-persistent-dna-methylation-and-tuberculosis-specific-immune-changes
#4
Andrew R DiNardo, Tomoki Nishiguchi, Emily M Mace, Kimal Rajapakshe, Godwin Mtetwa, Alexander Kay, Gugu Maphalala, W Evan Secor, Rojelio Mejia, Jordan S Orange, Cristian Coarfa, Kapil N Bhalla, Edward A Graviss, Anna M Mandalakas, George Makedonas
Epigenetic mechanisms, such as DNA methylation, determine immune cell phenotype. To understand the epigenetic alterations induced by helminth coinfections, we evaluated the longitudinal effect of ascariasis and schistosomiasis infection on CD4+ T cell DNA methylation and the downstream tuberculosis (TB)-specific and bacillus Calmette-Guérin-induced immune phenotype. All experiments were performed on human primary immune cells from a longitudinal cohort of recently TB-exposed children. Compared with age-matched uninfected controls, children with active Schistosoma haematobium and Ascaris lumbricoides infection had 751 differentially DNA-methylated genes, with 72% hypermethylated...
May 11, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29747491/gastric-mucosal-atrophy-impedes-housekeeping-gene-methylation-in-gastric-cancer-patients
#5
Jung-Hwan Oh, Mun-Gan Rhyu, Suk-Il Kim, Mi-Ri Yun, Jung-Ha Shin, Seung-Jin Hong
Purpose: Helicobacter pylori infection induces phenotype-stabilizing methylation and promotes gastric mucosal atrophy that can inhibit CpG-island methylation. Relationship between the progression of gastric mucosal atrophy and the initiation of CpG-island methylation was analyzed to delineate epigenetic period for neoplastic transformation. Materials and Methods: Normal-appearing gastric mucosa was biopsied from 110 H. pylori‒positive controls, 95 H. pylori‒negative controls, 99 gastric cancer patients, and 118 gastric dysplasia patients...
April 30, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29724825/deletion-of-ferroportin-in-murine-myeloid-cells-increases-iron-accumulation-and-stimulates-osteoclastogenesis-in-vitro-and-in-vivo
#6
Lei Wang, Bin Fang, Toshifumi Fujiwara, Kimberly Krager, Akshita Gorantla, Chaoyuan Li, Jian Q Feng, Michael L Jennings, Jian Zhou, Nukhet Aykin-Burns, Haibo Zhao
Osteoporosis, osteopenia, and pathological bone fractures are frequent complications of iron-overload conditions such as hereditary hemochromatosis, thalassemia, and sickle cell disease. Moreover, animal models of iron overload have revealed increased bone resorption and decreased bone formation. Although systemic iron overload affects multiple organs and tissues, leading to significant changes on bone modeling and remodeling, the cell autonomous effects of excessive iron on bone cells remain unknown. Here, to elucidate the role of cellular iron homeostasis in osteoclasts, we generated two mouse strains in which solute carrier family 40 member 1 (Slc40a1), a gene encoding ferroportin (FPN), the sole iron exporter in mammalian cells, were specifically deleted in myeloid osteoclast precursors or mature cells...
May 3, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29720294/adipogenic-genes-expression-in-relation-to-hepatic-steatosis-in-the-liver-of-two-duck-species
#7
F Hérault, C Duby, E Baéza, C Diot
Some studies have shown that expression of peroxisome proliferator-activated receptor gamma (PPARG), a key regulator of adipogenesis, and of some adipocyte-specific genes or adipokines are expressed in hepatic steatosis, leading to the concept of 'adipogenic hepatic steatosis' or 'hepatic adiposis.' Most of these studies were conducted in genetic obese mouse models or after manipulation of gene expression. The relevance of this concept to other species and more physiological models was here addressed in ducks which are able to develop hepatic steatosis after overfeeding...
May 3, 2018: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29703528/replication-of-a-gene-diet-interaction-at-cd36-nos3-and-pparg-in-response-to-omega-3-fatty-acid-supplements-on-blood-lipids-a-double-blind-randomized-controlled-trial
#8
Ju-Sheng Zheng, Jiewen Chen, Ling Wang, Hong Yang, Ling Fang, Ying Yu, Liping Yuan, Jueping Feng, Kelei Li, Jun Tang, Mei Lin, Chao-Qiang Lai, Duo Li
BACKGROUND: Modulation of genetic variants on the effect of omega-3 fatty acid supplements on blood lipids is still unclear. METHODS: In a double-blind randomized controlled trial, 150 patients with type 2 diabetes (T2D) were randomized into omega-3 fatty acid group (n = 56 for fish oil and 44 for flaxseed oil) and control group (n = 50) for 180 days. All patients were genotyped for genetic variants at CD36 (rs1527483), NOS3 (rs1799983) and PPARG (rs1801282)...
April 17, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29703268/exploring-the-mechanisms-of-resistance-to-teladorsagia-circumcincta-infection-in-sheep-through-transcriptome-analysis-of-abomasal-mucosa-and-abomasal-lymph-nodes
#9
Praveen K Chitneedi, Aroa Suárez-Vega, María Martínez-Valladares, Juan José Arranz, Beatriz Gutiérrez-Gil
The present study exploited the RNA-seq technology to analyze the transcriptome of target tissues affected by the Teladorsagia circumcincta infection in two groups of adult ewes showing different statuses against gastrointestinal nematode (GIN) infection with the aim of identifying genes linked to GIN infection resistance in sheep. For this, based on the accumulated faecal egg count of 18 adult Churra ewes subjected to a first experimental infection with T. circumcincta, six ewes were classified as resistant and six others as susceptible to the infection...
April 27, 2018: Veterinary Research
https://www.readbyqxmd.com/read/29693136/bioinformatics-analysis-and-verification-of-key-genes-associated-with-recurrent-respiratory-tract-infections
#10
Xiang Jin, Zhiyong Ji, Xiaodan Li, Rui Liu, Yinghui Guan
We evaluated the key genes related with recurrent respiratory tract infections (RRTIs), and then elucidated the possible molecular mechanisms of RRTIs. Neutrophil was isolated from peripheral bloods of the recurrent lower respiratory tract infection patients and healthy volunteers, respectively. The next generation sequencing information was obtained after RNA extraction, purification, library construction and sequencing. The sequencing information was preprocessed. Bioinformatics analysis including analysis of differentially expre-ssed genes (DEGs), Gene Ontology (GO) and pathway enrichment analysis, protein-protein interaction (PPI) analysis and transcription factors analysis were performed...
April 24, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29679223/association-between-lepr-fto-mc4r-and-pparg-2-polymorphisms-with-obesity-traits-and-metabolic-phenotypes-in-school-aged-children
#11
Sílvia M Almeida, José M Furtado, Paulo Mascarenhas, Maria E Ferraz, José C Ferreira, Mariana P Monteiro, Manuel Vilanova, Fernando P Ferraz
PURPOSE: Evaluate the relationship of leptin receptor (LEPR) rs1137101, fat mass obesity-associated (FTO) receptors 9939609, melanocortin-4 receptors (MC4R) rs2229616 and rs17782313, and proliferator-activated receptor-gamma (PPARG) rs1801282 with clinical and metabolic phenotypes in prepubertal children. RESEARCH QUESTION: What is the effect of polymorphisms on clinical and metabolic phenotypes in prepubertal children? METHODS: A cross-sectional descriptive study was performed to evaluate anthropometric features, percentage body fat (%BF), biochemical parameters, and genotype in 773 prepubertal children...
April 20, 2018: Endocrine
https://www.readbyqxmd.com/read/29678503/caffeine-inhibits-stat1-signaling-and-downregulates-inflammatory-pathways-involved-in-autoimmunity
#12
Merve Iris, Pei-Suen Tsou, Amr H Sawalha
Caffeine is a widely consumed pharmacologically active product. We focused on characterizing immunomodulatory effects of caffeine on peripheral blood mononuclear cells. Caffeine at high doses showed a robust downregulatory effect on cytokine activity and genes related to several autoimmune diseases including lupus and rheumatoid arthritis. Dose-dependent validation experiments showed downregulation at the mRNA levels of key inflammatory genes including STAT1, TNF, and PPARG. TNF and PPARG were suppressed even with the lowest caffeine dose tested, which corresponds to the serum concentration of caffeine after administration of one cup of coffee...
April 17, 2018: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/29671154/cell-mimicking-microparticles-influence-the-organization-growth-and-mechanophenotype-of-stem-cell-spheroids
#13
Nicholas R Labriola, Jessica S Sadick, Jeffrey R Morgan, Edith Mathiowitz, Eric M Darling
Substrate stiffness is known to alter cell behavior and drive stem cell differentiation, though most research in this area has been restricted to traditional, two-dimensional culture systems rather than more physiologically relevant, three-dimensional (3D) platforms. In this study, we utilized polymer-based, cell mimicking microparticles (CMMPs) to deliver distinct, stable mechanical cues to human adipose derived stem cells in 3D spheroid culture to examine changes in adipogenic differentiation response and mechanophenotype...
April 18, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29671030/abnormal-islet-sphingolipid-metabolism-in-type-1-diabetes
#14
Laurits J Holm, Lars Krogvold, Jane P Hasselby, Simranjeet Kaur, Laura A Claessens, Mark A Russell, Clayton E Mathews, Kristian F Hanssen, Noel G Morgan, Bobby P C Koeleman, Bart O Roep, Ivan C Gerling, Flemming Pociot, Knut Dahl-Jørgensen, Karsten Buschard
AIMS/HYPOTHESIS: Sphingolipids play important roles in beta cell physiology, by regulating proinsulin folding and insulin secretion and in controlling apoptosis, as studied in animal models and cell cultures. Here we investigate whether sphingolipid metabolism may contribute to the pathogenesis of human type 1 diabetes and whether increasing the levels of the sphingolipid sulfatide would prevent models of diabetes in NOD mice. METHODS: We examined the amount and distribution of sulfatide in human pancreatic islets by immunohistochemistry, immunofluorescence and electron microscopy...
April 18, 2018: Diabetologia
https://www.readbyqxmd.com/read/29666371/integration-of-human-adipocyte-chromosomal-interactions-with-adipose-gene-expression-prioritizes-obesity-related-genes-from-gwas
#15
David Z Pan, Kristina M Garske, Marcus Alvarez, Yash V Bhagat, James Boocock, Elina Nikkola, Zong Miao, Chelsea K Raulerson, Rita M Cantor, Mete Civelek, Craig A Glastonbury, Kerrin S Small, Michael Boehnke, Aldons J Lusis, Janet S Sinsheimer, Karen L Mohlke, Markku Laakso, Päivi Pajukanta, Arthur Ko
Increased adiposity is a hallmark of obesity and overweight, which affect 2.2 billion people world-wide. Understanding the genetic and molecular mechanisms that underlie obesity-related phenotypes can help to improve treatment options and drug development. Here we perform promoter Capture Hi-C in human adipocytes to investigate interactions between gene promoters and distal elements as a transcription-regulating mechanism contributing to these phenotypes. We find that promoter-interacting elements in human adipocytes are enriched for adipose-related transcription factor motifs, such as PPARG and CEBPB, and contribute to heritability of cis-regulated gene expression...
April 17, 2018: Nature Communications
https://www.readbyqxmd.com/read/29665413/genetic-risk-factors-for-post-transplantation-diabetes-mellitus-in-chinese-han-renal-allograft-recipients-treated-with-tacrolimus
#16
Xiaoming Zhang, Tongyi Men, Haitao Liu, Xianduo Li, Jianning Wang, Jiaju Lv
BACKGROUND: Post-transplantation diabetes mellitus (PTDM) is a serious metabolic complication after kidney transplantation. The aim of this study was to explore the association of clinical variables and five selected single nucleotide polymorphisms (SNPs) with PTDM in Chinese Han renal allograft recipients taking tacrolimus (TAC). METHODS: A total of 129 non-diabetic, primary, Chinese Han renal allograft recipients treated with TAC were enrolled. Five SNPs (CYP3A5 rs776741, rs776746, rs15524, CYP24A1 rs2296241, and PPARG rs1801282) were genotyped and analyzed...
April 14, 2018: Transplant Immunology
https://www.readbyqxmd.com/read/29626590/altered-expression-of-wfs1-and-notch2-genes-associated-with-diabetic-nephropathy-in-t2dm-patients
#17
Sahar A Sharaf, Nagwa A Kantoush, Dina F Ayoub, Alshaymaa A Ibrahim, Amaal A Abdelaal, Rokaya Abdel Aziz, Mahmoud M ElHefnawi, Amira N Ahmed
AIM: The increased incidence of type 2 diabetes mellitus (T2DM) and the importance of early identification and management of its complications, especially diabetic nephropathy (DN), have spotted the light on genetic factors that increase risk of T2DM and its related nephropathy. The present study aimed at investigating expression of (KCNJ11, ABCC8, JAZF1, WFS1, PPARG, NOTCH2 and EXOSC4) genes in peripheral blood of T2DM patients. METHOD: The study included 30 non-complicated T2DM patients, 30 patients with DN and 40 healthy controls...
April 4, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29626523/expression-of-genes-in-primo-vasculature-floating-in-lymphatic-endothelium-under-lipopolysaccharide-and-acupuncture-electric-stimulation
#18
Jun-Young Shin, Jong-Ok Ji, Da-Woon Choi, Sang-Heon Choi, Jong-Gu Choi, Min-Suk Rho, Ji Yoon Lee, Sang-Suk Lee
It is known that the existence of primo vascular system (PVS) including the primo nodes and vessels. However, it is poorly understood the relevant genes in the PVS system both patho- and physiologic condition. Here, we first examined the gene expression in primo vessels (PV) floating in lymphatic endothelium by isolation of PVS and lymphatic vessels (LV) containing PVS. To investigate therapeutic effects, both PV and LV containing PVS were isolated after lipopolysaccharides (LPS) injection and acupuncture electric stimulation (AES) at two acupoints of Joksamni (ST36) and Hapgok (LI04) following LPS...
April 4, 2018: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/29622583/a-pharmacogenetic-approach-to-the-treatment-of-patients-with-pparg-mutations
#19
Maura Agostini, Erik Schoenmakers, Junaid Beig, Louise Fairall, Istvan Szatmari, Odelia Rajanayagam, Frederick W Muskett, Claire Adams, A David Marais, Stephen O'Rahilly, Robert K Semple, Laszlo Nagy, Amit R Majithia, John W R Schwabe, Dirk J Blom, Rinki Murphy, Krishna Chatterjee, David B Savage
Loss-of-function mutations in PPARG cause familial partial lipodystrophy type 3 (FPLD3) and severe metabolic disease in many cases. Missense mutations in PPARG are present in ∼1:500 people. Whilst mutations are often binarily classified as 'benign' or 'deleterious', prospective functional classification of all missense PPARG variants suggests that their impact is graded. Furthermore, in testing novel mutations with both prototypic 'endogenous' (e.g. prostaglandin J2 (PGJ2)) and synthetic ligands (thiazolidinediones, tyrosine agonists), we observed that synthetic agonists selectively rescue function of some PPARγ mutants...
April 5, 2018: Diabetes
https://www.readbyqxmd.com/read/29620215/integrated-analysis-of-the-gene-expression-profile-and-dna-methylation-profile-of-obese-patients-with-type-2-diabetes
#20
Juan Shen, Bin Zhu
In order to better understand the etiology of obese type 2 diabetes (T2D) at the molecular level, the present study investigated the gene expression and DNA methylation profiles associated with T2D via systemic analysis. Gene expression (GSE64998) and DNA methylation profiles (GSE65057) from liver tissues of healthy controls and obese patients with T2D were downloaded from the Gene Expression Omnibus database. Differentially‑expressed genes (DEGs) and differentially‑methylated genes (DMGs) were identified using the Limma package, and their overlapping genes were additionally determined...
March 28, 2018: Molecular Medicine Reports
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