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https://www.readbyqxmd.com/read/28648894/compositional-analysis-of-endogenous-porphyrins-from-helicobacter-pylori
#1
A Battisti, P Morici, G Signore, F Ghetti, A Sgarbossa
Bacteria able to accumulate porphyrins can be inactivated by visible light irradiation thanks to the photosensitizing properties of this class of aromatic pigments (photodynamic therapy, PDT). Since the bacterial resistance to antibiotic is growing, PDT is becoming a valid alternative. In this context, the pathogen Helicobacter pylori (Hp) is a suitable target for PDT since it spontaneously produces and accumulates porphyrins. It is then important to understand the spectroscopic behavior of these endogenous species to exploit them as photosensitizers, thus improving the results given by the application of PDT in the treatment of Hp infections...
June 19, 2017: Biophysical Chemistry
https://www.readbyqxmd.com/read/28576278/spectroscopic-characterization-and-fluorescence-imaging-of-helicobacter-pylori-endogenous-porphyrins
#2
Antonella Battisti, Paola Morici, Francesco Ghetti, Antonella Sgarbossa
Conventional antimicrobial strategies have become increasingly ineffective due to the rapid emergence of antibiotic resistance among pathogenic bacteria. In order to overcome this problem, antimicrobial PhotoDynamic Therapy (PDT) is considered a promising alternative therapy. PDT has a broad spectrum of action and low mutagenic potential. It is particularly effective when microorganisms present endogenous photosensitizing pigments. Helicobacter pylori (Hp), a pathogen notoriously responsible of severe gastric infections (chronic gastritis, peptic ulcer, MALT lymphoma and gastric adenocarcinoma), produces and accumulates the photosensitizers protoporphyrin IX and coproporphyrin, thus it might be a suitable target of antimicrobial PDT...
May 26, 2017: Biophysical Chemistry
https://www.readbyqxmd.com/read/28343654/negative-concordant-t-waves-during-paced-ventricular-rhythm-an-honest-enemy-is-better-than-a-false-friend
#3
Irene di Matteo, Pasquale Crea
The ECG diagnosis of myocardial infarction and ischemia in pacemaker patients is often challenging. The three criteria, proposed by Sgarbossa et al. in 1996, useful to suspect myocardial ischaemia in patient with left bundle branch block were demonstrated to be valid also in pacemaker patients. In the last years, concordant negative T waves in patients with ventricular paced rhythm were linked to various expressions of acute myocardial injury. If available, comparison with previous ECG is crucial. Partial persistence of cardiac memory during fusion beats created an anomalous concordance between negative T waves and QRS axis and could induce erroneous suspicions...
July 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28185080/wellens-syndrome-can-indicate-high-grade-lad-stenosis-in-case-of-left-bundle-branch-block
#4
Steffen Grautoff
Diagnosing acute myocardial infarction (AMI) in left bundle branch block (LBBB) is challenging. Modified Sgarbossa criteria are known to help detect AMI in LBBB. This is a report about an electrocardiogram (ECG) with Wellens' signs in combination with a pre-existing LBBB. The ECG of a patient with fluctuating chest pain showed very subtle and one day later more obvious Wellens'signs. A left anterior descending artery (LAD) stenosis was diagnosed and successfully treated. Wellens' syndrome can be diagnosed in a case of LBBB and help detect a high-grade LAD stenosis even if modified Sgarbossa criteria are not met...
March 2017: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/28114719/-right-bundle-branch-block-left-bundle-branch-block-pace-maker-in-case-of-acute-coronary-syndrome-is-the-ecg-of-any-value
#5
REVIEW
Steffen Grautoff
The 12 lead ECG is difficult to evaluate if there is a persistent right or even left bundle block or a pace maker continually stimulating the right ventricle. Despite these pre-existing or new ECG changes it might still be possible to detect variations which can hint to an ST-elevation myocardial infarction (STEMI). Diagnosing significant ST elevations in a case of right bundle block is not very challenging. If the ECG shows a left bundle block the modified Sgarbossa criteria should be used for evaluation. These criteria can also be used in a pace maker ECG...
January 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28027906/assessment-of-smith-algorithms-for-the-diagnosis-of-acute-myocardial-infarction-in-the-presence-of-left-bundle-branch-block
#6
Andrea Di Marco, Ignasi Anguera, Marcos Rodríguez, Alessandro Sionis, Antoni Bayes-Genis, Jany Rodríguez, Albert Ariza-Solé, José Carlos Sánchez-Salado, Mario Díaz-Nuila, Mónica Masotti, Roger Villuendas, Paolo Dallaglio, Joan Antoni Gómez-Hospital, Ángel Cequier
INTRODUCTION AND OBJECTIVES: Recently, a new electrocardiography algorithm has shown promising results for the the diagnosis of acute myocardial infarction in the presence of left bundle branch block (LBBB). We aimed to assess these new electrocardiography rules in a cohort of patients referred for primary percutaneous coronary intervention (pPCI). METHODS: Retrospective observational cohort study that included all patients with suspected myocardial infarction and LBBB on the presenting electrocardiogram, referred for pPCI to 4 tertiary hospitals in Barcelona, Spain...
December 24, 2016: Revista Española de Cardiología
https://www.readbyqxmd.com/read/27618475/smith-modified-sgarbossa-criteria-and-paced-rhythms-a%C3%A2-case-report
#7
Nana Sefa, Kelly N Sawyer
BACKGROUND: As the incidence of left bundle branch blocks (LBBBs) and paced-rhythms electrocardiograms (ECGs) increase in the aging global population, the need for rapid and accurate diagnosis of ST-elevation myocardial infarction (STEMI) or STEMI equivalents in patients with these rhythms becomes more imperative. The Sgarbossa and Smith-modified Sgarbossa criteria have been documented to enhance the diagnosis of STEMI in the setting of LBBBs. However, there is a growing body of literature that suggests that these criteria can also be applied for the diagnosis of STEMI in patients with paced rhythms...
November 2016: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27539980/bet-2-diagnosing-acute-myocardial-infarction-in-the-presence-of-ventricular-pacing-can-sgarbossa-criteria-help
#8
REVIEW
Arunan Jothieswaran, Richard Body
The Sgarbossa criteria can be used to identify patients who have acute myocardial infarction (AMI) in the presence of left bundle branch block, which obscures the usual changes associated with ST elevation myocardial infarction. Patients with ventricular paced rhythm have ECG changes with similar morphology to left bundle branch block. A short-cut systematic review was carried out to establish whether the Sgarbossa criteria can accurately diagnose AMI in the presence of ventricular paced rhythm. Three studies were directly relevant to the question...
September 2016: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/27430208/ecg-evaluation-in-patients-with-pacemaker-and-suspected-acute-coronary-syndrome-which-score-should-we-apply
#9
Pedro Freitas, Miguel Borges Santos, Mariana Faria, Gustavo Rodrigues, Nélson Vale, Rui Campante Teles, Manuel Almeida, Miguel Mendes
BACKGROUND/PURPOSE: In patients with right ventricular pacing, the ECG shows a left bundle branch block (LBBB) pattern. There are several criteria to diagnose ST-elevation myocardial infarction (STEMI) in patients with LBBB. The aim of this study was to validate and compare Sgarbossa's with two new scores - Selvester's and Smith's - in this context. METHODS: We identified pacemaker patients submitted to coronary angiography due to acute coronary syndrome. ECGs were analyzed by 2 blinded cardiologists...
September 2016: Journal of Electrocardiology
https://www.readbyqxmd.com/read/27402134/diagnosis-of-myocardial-infarction-and-ischemia-in-the-setting-of-bundle-branch-block-and-cardiac-pacing
#10
REVIEW
B Herweg, M B Marcus, S S Barold
The diagnosis of myocardial infarction (MI) in the presence of left bundle branch block (LBBB) or during ventricular pacing (VP) is challenging because of inherent changes in the sequence of ventricular depolarization and repolarization associated with both conditions. Although LBBB and right ventricular (RV) pacing may both produce abnormalities in the ECG, it is often possible to diagnose an acute MI (AMI) or an old MI based on selected morphologic changes. Primary ST-segment changes scoring 3 points or greater according to the Sgarbossa criteria are highly predictive of an AMI in patients with LBBB or RV pacing...
September 2016: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/27318856/evaluation-of-t-wave-morphology-in-patients-with-left-bundle-branch-block-and-suspected-acute-coronary-syndrome
#11
H Pendell Meyers, Elias Jaffa, Stephen W Smith, Weiying Drake, Alexander T Limkakeng
BACKGROUND: T-wave morphology in the setting of left bundle branch block (LBBB) has been proposed as an indicator of myocardial ischemia. OBJECTIVES: We sought to identify T-wave morphology findings in patients with LBBB that predict non-ST-segment elevation myocardial infarction (NSTEMI). We hypothesized that two or more contiguous leads with concordant T waves would be predictive of NSTEMI. METHODS: This was a retrospective cohort study performed by chart review in a tertiary care center emergency department...
September 2016: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27265726/magnetic-hyperthermia-efficiency-and-1-h-nmr-relaxation-properties-of-iron-oxide-paclitaxel-loaded-plga-nanoparticles
#12
Maria R Ruggiero, Simonetta Geninatti Crich, Elisabetta Sieni, Paolo Sgarbossa, Michele Forzan, Eleonora Cavallari, Rachele Stefania, Fabrizio Dughiero, Silvio Aime
Magnetic iron oxide nanoparticles (Fe-NPs) can be exploited in biomedicine as agents for magnetic fluid hyperthermia (MFH) treatments and as contrast enhancers in magnetic resonance imaging. New, oleate-covered, iron oxide particles have been prepared either by co-precipitation or thermal decomposition methods and incorporated into poly(lactic-co-glycolic acid) nanoparticles (PLGA-Fe-NPs) to improve their biocompatibility and in vivo stability. Moreover, the PLGA-Fe-NPs have been loaded with paclitaxel to pursue an MFH-triggered drug release...
July 15, 2016: Nanotechnology
https://www.readbyqxmd.com/read/27193490/metal-complexes-with-di-n-heterocyclic-carbene-ligands-bearing-a-rigid-ortho-meta-or-para-phenylene-bridge
#13
Marco Monticelli, Cristina Tubaro, Marco Baron, Marino Basato, Paolo Sgarbossa, Claudia Graiff, Gianluca Accorsi, Thomas P Pell, David J D Wilson, Peter J Barnard
Three novel dinuclear bis-dicarbene silver(i) complexes of general formula [Ag2(MeIm-phenylene-MeIm)2](PF6)2 (Im = imidazol-2-ylidene) were synthesized. The corresponding copper(i) and gold(i) complexes were obtained by transmetalation of the di(N-heterocyclic carbene) ligand from the silver(i) species, and both coordination geometry and stoichiometry are maintained for all three group 11 metals as expected. The photophysical properties of the Ag(i) and Au(i) complexes were also investigated and discussed; in particular the most strongly emitting complex was also studied via DFT calculations...
June 21, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27140182/three-arachidonoylamide-derivatives-inhibit-pro-inflammatory-genes-expression-by-modulating-nf-kb-and-ap1-activities
#14
Alex Gregorelli, Anna Sgarbossa, Shahbaz Khan, Annunziata Soriente, Margherita De Rosa, Carmela Saturnino, Marta Menegazzi
BACKGROUND: Since the anti-inflammatory activity of arachidonic acid derivatives was previously reported, we synthesized three new amide derivatives of arachidonic acid (AA-Ds) and tested their anti-inflammatory effects on an in vitro skin inflammation model. Aim of our study was to find derivatives of natural compounds able to down regulate inflammatory signal transduction pathway. METHODS: Human keratinocytes cell line (HaCaT) was cultured and induced by cytokines in the presence of AA-Ds...
2016: Medicinal Chemistry
https://www.readbyqxmd.com/read/27091803/sgarbossa-criteria-for-acute-myocardial-infarction
#15
Debraj Das, Brent M McGrath
No abstract text is available yet for this article.
October 18, 2016: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/27041492/comparison-of-the-qrs-complex-st-segment-and-t-wave-among-patients-with-left-bundle-branch-block-with-and-without-acute-myocardial-infarction
#16
Kenneth W Dodd, Kendra D Elm, Stephen W Smith
BACKGROUND: The modified Sgarbossa criteria have been validated as a rule for diagnosis of acute coronary occlusion (ACO) in left bundle branch block (LBBB). However, no analysis has been done on differences in the QRS complex, T-wave, or ST-segment concordance of < 1 mm in the derivation or validation studies. Furthermore, there was no comparison of patients with acute myocardial infarction (AMI) but without ACO (i.e., non-ST-elevation myocardial infarction [non-STEMI]) to patients with ACO or without AMI (no MI)...
July 2016: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27003375/left-bundle-branch-block-chest-pain-and-catheterization-laboratory-activation-an-unavoidable-cascade-reaction
#17
G Ciliberti, M Del Pinto, F Notaristefano, G Zingarini, G Ambrosio, C Cavallini
Identification of acute myocardial infarction (AMI) in the presence of left bundle branch block (LBBB) remains challenging. European guidelines recommend prompt reperfusion therapy in patients with suspected ongoing myocardial ischemia and new or presumably new LBBB, whereas AHA/ACC guidelines state that LBBB should not be considered diagnostic of AMI in isolation. Sgarbossa criteria and their recent modified version with the introduction of ST/S ratio can be helpful in this setting. A clinical-instrumental algorithm to manage suspected AMI in the presence of LBBB has been recently proposed...
July 2016: Journal of Electrocardiology
https://www.readbyqxmd.com/read/26968401/dolichol-a-component-of-the-cellular-antioxidant-machinery
#18
Gabriella Cavallini, Antonella Sgarbossa, Ilaria Parentini, Ranieri Bizzarri, Alessio Donati, Francesco Lenci, Ettore Bergamini
Dolichol, an end product of the mevalonate pathway, has been proposed as a biomarker of aging, but its biological role, not to mention its catabolism, has not been fully understood. UV-B radiation was used to induce oxidative stress in isolated rat hepatocytes by the collagenase method. Effects on dolichol, phospholipid-bound polyunsaturated fatty acids (PL-PUFA) and known lipid soluble antioxidants [coenzyme Q (CoQ) and α-tocopherol] were studied. The increase in oxidative stress was detected by a probe sensitive to reactive oxygen species (ROS)...
April 2016: Lipids
https://www.readbyqxmd.com/read/26678648/validation-of-the-modified-sgarbossa-criteria-for-acute-coronary-occlusion-in-the-setting-of-left-bundle-branch-block-a-retrospective-case-control-study
#19
H Pendell Meyers, Alexander T Limkakeng, Elias J Jaffa, Anjni Patel, B Jason Theiling, Salim R Rezaie, Todd Stewart, Cassandra Zhuang, Vijaya K Pera, Stephen W Smith
BACKGROUND: The modified Sgarbossa criteria were proposed in a derivation study to be superior to the original criteria for diagnosing acute coronary occlusion (ACO) in left bundle branch block (LBBB). The new rule replaces the third criterion (5 mm of excessively discordant ST elevation [STE]) with a proportion (at least 1 mm STE and STE/S wave ≤-0.25). We sought to validate the modified criteria. METHODS: This retrospective case-control study was performed by chart review in 2 tertiary care center emergency departments (EDs) and 1 regional referral center...
December 2015: American Heart Journal
https://www.readbyqxmd.com/read/26612003/a-case-of-chemical-scalp-burns-after-hair-highlights-experimental-evidence-of-oxidative-injuries
#20
Roberta Bertani, Paolo Sgarbossa, Flavio Pendolino, Giangiacomo Facchin, Rossella Snenghi
Hair highlights are quite common procedures carried out in hair salons by using a mixture of a lightening powder containing persulfates with a suspension containing hydrogen peroxide: a representative case of chemical scalp burns is described as a consequence of this treatment. The aim of the paper is to demonstrate the strict relationship between the scalp damage and the commercial products used in a case of hair highlighting. The results of some chemical analyses have been reported, showing, in particular, that the chemical reactivity of the mixture changes in the time, thus strongly suggesting that the procedure for the application of the mixture is critical for the occurrence of possible accidents...
December 2016: Cutaneous and Ocular Toxicology
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