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https://www.readbyqxmd.com/read/29166564/optical-control-of-dopamine-receptors-using-a-photoswitchable-tethered-inverse-agonist
#1
Prashant Donthamsetti, Nils Winter, Matthias Schönberger, Joshua Levitz, Cherise Stanley, Jonathan A Javitch, Ehud Y Isacoff, Dirk Trauner
Family A G protein-coupled receptors (GPCRs) control diverse biological processes and are of great clinical relevance. Their archetype rhodopsin becomes naturally light sensitive by binding covalently to the photoswitchable tethered ligand (PTL) retinal. Other GPCRs, however, neither bind covalently to ligands nor are light sensitive. We sought to impart the logic of rhodopsin to light-insensitive Family A GPCRs in order to enable their remote control in a receptor-specific, cell-type-specific and spatio-temporally precise manner...
November 22, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29165678/the-genealogy-of-dementia-praecox-i-signs-and-symptoms-of-delusional-psychoses-from-1880-to-1900
#2
Kenneth S Kendler
We can trace, with high congruence, the clinical syndromes of depression and mania as described over the 20th century in psychiatric textbooks back to 1880 and to the earliest writing of Kraepelin published in 1883. However, this is not the case for Kraepelin's 2 delusional syndromes central to his overall nosology: Dementia Paranoides (later paranoid schizophrenia) and Paranoia. A detailed examination of 28 textbook descriptions of delusional psychoses from 1880 to 1900 reveals a diverse and partially overlapping set of syndromes with an admixture of symptoms and signs that would later be considered indicative of Dementia Paranoides and Paranoia...
November 19, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29165654/infusions-of-nerve-growth-factor-into-the-developing-frontal-cortex-leads-to-deficits-in-behavioral-flexibility-and-increased-perseverance
#3
Sagar J Desai, Brian L Allman, Nagalingam Rajakumar
In the pursuit of further establishing a neurodevelopmental animal model to investigate the mechanisms underlying impaired executive function, a core and severely debilitating symptom of schizophrenia, we sought to characterize the deficits in behavioral flexibility in adult rats following neonatal infusions of nerve growth factor (NGF) into the medial part of the developing frontal cortex. Our previous studies using this neonatal frontal cortical lesion model have shown that it leads to adult-onset positive and negative symptom-like features, and several neuropathological abnormalities of schizophrenia...
November 17, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29165095/metabolic-syndrome-and-cardiovascular-risk-in-people-treated-with-long-acting-injectable-antipsychotics
#4
Vanessa Sanchez-Martinez, Dolores Romero-Rubio, Maria Jose Abad-Perez, Maria Amparo Descalzo-Cabades, Sofia Alonso-Gutierrez, Jose Salazar-Fraile, Vicente Montagud, Lorenzo Facila
BACKGROUND: People with schizophrenia and other severe mental disorders have an increased mortality mainly attributed to natural causes, specifically cardiovascular disease and cancer. The metabolic syndrome and the Framingham Risk Score are epidemiologic tools related to long-term cardiovascular disease risk and they are increased in people with severe mental disorders. This increase has been attributed both to the disorder itself and to the use of antipsychotic drugs. OBJECTIVE: To quantify the cardiovascular risk in a group of people treated with long-acting injectable antipsychotics...
November 20, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29165075/preferential-formulation-of-second-generation-antipsychotic-asenapine-as-inclusion-complex-with-sulphobutylether-%C3%AE-cd-captisol-in-vitro-and-in-vivo-evaluation
#5
Amelia Makarand Avachat, Juilee A Kulkarni, Charul M Avachat, Rohan Pradhan, Tushar S Suryawanshi, E M Khan, Elvis A F Martis, Evans C Coutinho, Subhash Padhye
Asenapine is an anti-psychotic agent approved by the US-FDA for treatment of acute schizophrenia and manic or bipolar I disorder in adults. It is poorly absorbed when administered orally, hence exhibits poor oral bioavailability, which limits its use in clinical practice. Consequently, enhancement in its solubility through complexation with three different cyclodextrins, viz. βCD (β cyclodextrin), HPβCD (Hydroxypropyl β cyclodextrin) and sulphobutylether-βCD (Captisol®) was attempted and compared. Kneading method was used for preparation of inclusion complexes which were characterized by FTIR, DSC, and XRD methods...
November 20, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/29164967/increased-serum-midkine-levels-in-autism-spectrum-disorder-patients
#6
Erman Esnafoglu, Selma Cırrık
BACKGROUND: Midkine (MK) is a heparin binding growth factor and is involved in neurogenesis, neural development and neuroprotection. Additionally MK may contribute to cancer development and pathogenesis of neurodegenerative disorders and schizophrenia. Considering these effects of midkine, this study researched whether MK is involved in Autism spectrum disorders (ASD) pathogenesis. METHODS: We evaluated serum MK levels of 38 patients with ASD and 32 healthy control group...
November 22, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29164930/relapse-risk-assessment-for-schizophrenia-patients-rasp-a-new-self-report-screening-tool
#7
Dawn Velligan, William Carpenter, Heidi C Waters, Nicole M Gerlanc, Susan N Legacy, Charles Ruetsch
OBJECTIVES: The Relapse Assessment for Schizophrenia Patients (RASP) was developed as a 6- question self-report screener that measures indicators of Increased Anxiety and Social Isolation to assess patient stability and predict imminent relapse. This paper describes the development and psychometric characteristics of the RASP. METHODS: The RASP and Positive and Negative Syndrome Scale (PANSS) were administered to patients with schizophrenia (N=166) 3 separate times...
November 22, 2017: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/29164928/clozapine-diabetes-mellitus-cardiovascular-risk-and-mortality-results-of-a-21-year-naturalistic-study-in-patients-with-schizophrenia-and-schizoaffective-disorder
#8
Katlyn L Nemani, M Claire Greene, Melissa Ulloa, Brenda Vincenzi, Paul M Copeland, Sulaiman Al-Khadari, David C Henderson
The goal of this 21-year naturalistic study of clozapine treated patients was to examine the cardiovascular risk factors following clozapine initiation and resultant mortality estimates from cardiovascular disease. Data was collected from medical records of clozapine treated patients with schizophrenia or schizoaffective disorder from January 1992 to February 2012. Demographics, clozapine dosage and laboratory results were extracted at 12-month intervals. At clozapine initiation, the mean age of 96 patients was 36...
November 22, 2017: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/29164927/a-case-of-a-patient-with-residual-symptoms-of-schizophrenia-who-relapsed-following-treatment-with-the-topical-corticosteroid-clobetasol-a-review-of-its-risk-of-systemic-absorption-and-possibility-of-exacerbating-psychosis
#9
David R Spiegel, Umer Arsani, Stephanie Le
Almost fifty percent of patients with schizophrenia experience some type of dermatitis. The standard treatment for dermatitis is a topical corticosteroid. Despite their demonstrated effectiveness, topical corticosteroids are associated with various side effects that may limit their use. These include generalized adverse effects from systemic absorption, such as suppression of the hypothalamic-pituitary-adrenal axis. While dose-related, oral corticosteroid-induced psychiatric symptoms, such as psychosis, are well documented, the literature is devoid of cases of topical corticosteroids precipitating psychosis...
November 22, 2017: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/29164828/attenuated-psychosis-and-basic-self-disturbance-as-risk-factors-for-depression-and-suicidal-ideation-behaviour-in-community-dwelling-adolescents
#10
Dan Koren, Lily Rothschild-Yakar, Liza Lacoua, Anat Brunstein-Klomek, Aya Zelezniak, Josef Parnas, Golan Shahar
BACKGROUND AND AIMS: Adolescents at clinical high risk (CHR) for psychosis, as defined by the presence of attenuated psychosis symptoms (APS), exhibit increased levels of suicidal ideation and behaviour. However, no research thus far has examined the link between basic self-disturbances (SDs), an established marker for CHR, and suicidality/self-harm in this population. The goal of this pilot study was to assess the association between SD, depression and suicidal ideation and behaviour among non-help-seeking adolescents from the community...
November 22, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29164787/factors-related-to-duration-of-untreated-psychosis-of-first-episode-schizophrenia-spectrum-disorder
#11
Yong Qiu, Leijun Li, Zhaoyu Gan, Jihui Wang, Liangrong Zheng, Jiaoshi Zhao, Nianhong Guan, Qinling Wei
AIM: Duration of untreated psychosis (DUP) is associated with outcome and functioning. It is expected that scientists will find factors that modulate DUP, but thus far, research on this topic has shown inconsistent results. Furthermore, similar studies in China are insufficient. This study aims to explore social and clinical factors for DUP in South China and to learn the influence that family plays on DUP through their awareness of psychosis. METHODS: Participants included 216 patients with first episode schizophrenia spectrum disorder...
November 22, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29164477/genetic-variants-within-molecular-targets-of-antipsychotic-treatment-effects-on-treatment-response-schizophrenia-risk-and-psychopathological-features
#12
Marco Calabrò, Stefano Porcelli, Concetta Crisafulli, Sheng-Min Wang, Soo-Jung Lee, Changsu Han, Ashwin A Patkar, Prakash S Masand, Diego Albani, Ilaria Raimondi, Gianluigi Forloni, Sofia Bin, Carlotta Cristalli, Vilma Mantovani, Chi-Un Pae, Alessandro Serretti
Schizophrenia (SCZ) is a common and severe mental disorder. Genetic factors likely play a role in its pathophysiology as well as in treatment response. In the present study, we investigated the effects of several single nucleotide polymorphisms (SNPs) within 9 genes involved with antipsychotic (AP) mechanisms of action. Two independent samples were recruited. The Korean sample included 176 subjects diagnosed with SCZ and 326 healthy controls, while the Italian sample included 83 subjects and 194 controls. AP response as measured by the positive and negative syndrome scale (PANSS) was the primary outcome, while the secondary outcome was the SCZ risk...
November 21, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29163985/response-to-inhaled-loxapine-in-patients-with-schizophrenia-or-bipolar-i-disorder-panss-ec-responder-analyses
#13
Scott Zeller, Leslie Zun, James V Cassella, Daniel A Spyker, Paul P Yeung
Background: Efficacy of inhaled loxapine 5 or 10 mg in treating agitation was shown using the Positive and Negative Syndrome Scale - Excited Component (PANSS-EC) in two Phase III randomised, double-blind, placebo-controlled trials in 344 agitated patients with schizophrenia and 314 patients with bipolar I disorder (Clinicaltrials.gov: NCT00628589, NCT00721955). Aims: To examine the five individual items comprising the PANSS-EC and the percentage of patients achieving a clinical response (reduction of ≥40%) in PANSS-EC (Response-40) for these two studies...
November 2017: BJPsych Open
https://www.readbyqxmd.com/read/29163982/individual-differences-in-schizophrenia
#14
Edmund T Rolls, Wenlian Lu, Lin Wan, Hao Yan, Chuanyue Wang, Fude Yang, Yunlong Tan, Lingjiang Li, Hao Yu, Peter F Liddle, Lena Palaniyappan, Dai Zhang, Weihua Yue, Jianfeng Feng
Background: Whether there are distinct subtypes of schizophrenia is an important issue to advance understanding and treatment of schizophrenia. Aims: To understand and treat individuals with schizophrenia, the aim was to advance understanding of differences between individuals, whether there are discrete subtypes, and how first-episode patients (FEP) may differ from multiple episode patients (MEP). Method: These issues were analysed in 687 FEP and 1880 MEP with schizophrenia using the Positive and Negative Syndrome Scale for (PANSS) schizophrenia before and after antipsychotic medication for 6 weeks...
November 2017: BJPsych Open
https://www.readbyqxmd.com/read/29163244/peripheral-transcription-of-nrg-erbb-pathway-genes-are-upregulated-in-treatment-resistant-schizophrenia
#15
Md Shaki Mostaid, Ting Ting Lee, Gursharan Chana, Suresh Sundram, Cynthia Shannon Weickert, Christos Pantelis, Ian Everall, Chad Bousman
Investigation of peripheral gene expression patterns of transcripts within the NRG-ErbB signaling pathway, other than neuregulin-1 (NRG1), among patients with schizophrenia and more specifically treatment-resistant schizophrenia (TRS) is limited. The present study built on our previous work demonstrating elevated levels of NRG1 EGFα, EGFβ, and type I(Ig2) containing transcripts in TRS by investigating 11 NRG-ErbB signaling pathway mRNA transcripts (NRG2, ErbB1, ErbB2, ErbB3, ErbB4, PIK3CD, PIK3R3, AKT1, mTOR, P70S6K, eIF4EBP1) in whole blood of TRS patients (N = 71) and healthy controls (N = 57)...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29163240/interleukin-6-in-schizophrenia-is-there-a-therapeutic-relevance
#16
REVIEW
Milica Milovan Borovcanin, Ivan Jovanovic, Gordana Radosavljevic, Jelena Pantic, Slavica Minic Janicijevic, Nebojsa Arsenijevic, Miodrag L Lukic
Renewing interest in immune aspects of schizophrenia and new findings about the brain-fat axis encourage us to discuss the possible role of interleukin-6 (IL-6) in schizophrenia. Previously, it was suggested that a primary alteration of the innate immune system may be relevant in schizophrenia. Functional dichotomy of IL-6 suggests that this chemical messenger may be responsible for regulating the balance between pro- and anti-inflammatory responses, with tissue-specific properties at the periphery and in the central nervous system...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29163233/symptom-overlap-and-screening-for-symptoms-of-attention-deficit-hyperactivity-disorder-and-psychosis-risk-in-help-seeking-psychiatric-patients
#17
Salvatore Corbisiero, Anita Riecher-Rössler, Jacqueline Buchli-Kammermann, Rolf-Dieter Stieglitz
Symptoms of attention-deficit/hyperactivity disorder (ADHD) and psychosis risk share features which might represent an early vulnerability marker for schizophrenia. Early detection of individuals with this symptomatic overlap is relevant and may assist clinicians in their decision making for diagnosis and treatment. This study sought to analyze the capability of different instruments in the screening of patients for ADHD symptoms or at psychosis risk, assess their classification accuracy, and describe the extent of symptoms overlap between them...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29163090/community-violence-exposure-and-conduct-problems-in-children-and-adolescents-with-conduct-disorder-and-healthy-controls
#18
Linda Kersten, Noortje Vriends, Martin Steppan, Nora M Raschle, Martin Praetzlich, Helena Oldenhof, Robert Vermeiren, Lucres Jansen, Katharina Ackermann, Anka Bernhard, Anne Martinelli, Karen Gonzalez-Madruga, Ignazio Puzzo, Amy Wells, Jack C Rogers, Roberta Clanton, Rosalind H Baker, Liam Grisley, Sarah Baumann, Malou Gundlach, Gregor Kohls, Miguel A Gonzalez-Torres, Eva Sesma-Pardo, Roberta Dochnal, Helen Lazaratou, Zacharias Kalogerakis, Aitana Bigorra Gualba, Areti Smaragdi, Réka Siklósi, Dimitris Dikeos, Amaia Hervás, Aranzazu Fernández-Rivas, Stephane A De Brito, Kerstin Konrad, Beate Herpertz-Dahlmann, Graeme Fairchild, Christine M Freitag, Arne Popma, Meinhard Kieser, Christina Stadler
Exposure to community violence through witnessing or being directly victimized has been associated with conduct problems in a range of studies. However, the relationship between community violence exposure (CVE) and conduct problems has never been studied separately in healthy individuals and individuals with conduct disorder (CD). Therefore, it is not clear whether the association between CVE and conduct problems is due to confounding factors, because those with high conduct problems also tend to live in more violent neighborhoods, i...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29163052/the-thymus-neocortex-hypothesis-of-the-brain-a-cell-basis-for-recognition-and-instruction-of-self
#19
Silvia Sánchez-Ramón, Florence Faure
The recognition of internal and external sources of stimuli, the self from non-self, seems to be an intrinsic property to the adequate functioning of the immune system and the nervous system, both complex network systems that have evolved to safeguard the self biological identity of the organism. The mammalian brain development relies on dynamic and adaptive processes that are now well described. However, the rules dictating this highly constrained developmental process remain elusive. Here we hypothesize that there is a cellular basis for brain selfhood, based on the analogy of the global mechanisms that drive the self/non-self recognition and instruction by the immune system...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29163023/perinatal-asphyxia-in-rat-alters-expression-of-novel-schizophrenia-risk-genes
#20
Alessandra Paparelli, Keiko Iwata, Tomoyasu Wakuda, Conrad Iyegbe, Robin M Murray, Nori Takei
Epidemiological studies suggest that obstetric complications, particularly those related to hypoxia during labor and delivery, are a risk factor for development of schizophrenia. The impact of perinatal asphyxia on postnatal life has been studied in a rodent model of global hypoxia, which is accompanied by cesarean section birth. This asphyxia model shows several behavioral, pharmacological, neurochemical, and neuroanatomical abnormalities in adulthood that have relevance to schizophrenia. Further, it is suggested that schizophrenia has a strong genetic component, and indeed novel candidate genes were recently identified by a genome-wide association study...
2017: Frontiers in Molecular Neuroscience
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