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https://www.readbyqxmd.com/read/28938151/elucidation-of-shared-and-specific-white-matter-findings-underlying-psychopathology-clusters-in-schizophrenia
#1
Jeanette Lim, Rowena Chin, New Fei Ho, Max Lam, Min Yi Sum, Simon Collinson, Lisa Phillips, Tih-Shih Lee, Balázs Zoltán Gulyás, Juan Zhou, Kang Sim
BACKGROUND: Schizophrenia is associated with diverse white matter (WM) brain abnormalities. In this study, we sought to examine the WM microstructural findings which underlie clinical psychopathology clusters in schizophrenia and hypothesized that these symptom clusters are associated with common and unique WM tracts. METHODS: Overall, 76 healthy controls (HC), and 148 patients with schizophrenia (SZ) were recruited and severity of symptomatology in schizophrenia was assessed using the Positive and Negative Syndrome Scale...
September 1, 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/28937973/oral-and-dental-health-issues-in-people-with-mental-disorders
#2
Julio Torales, Iván Barrios, Israel González
Patients with mental disorders are subject to a greater number of risk factors for oral and dental disease than the general population. This is mostly caused by the side effects of the medications that they receive, lack of self-care, difficulty to access health services, a negative attitude towards healthcare providers, and patients’ lack of cooperation in dental treatments. The most common psychiatric disorders in our population are depression, anxiety disorders, schizophrenia, bipolar disorder, and dementia...
September 21, 2017: Medwave
https://www.readbyqxmd.com/read/28937706/durability-of-therapeutic-response-with-long-term-aripiprazole-lauroxil-treatment-following-successful-resolution-of-an-acute-episode-of-schizophrenia
#3
Joseph P McEvoy, Robert Risinger, Serhiy Mykhnyak, Yangchun Du, Chih-Chin Liu, Arielle D Stanford, Peter J Weiden
OBJECTIVE: To evaluate durability of therapeutic effect of long-term treatment with aripiprazole lauroxil in patients with schizophrenia following successful treatment of an acute psychotic episode. METHODS: This post hoc analysis assessed long-term outcomes for a subgroup of patients who entered a 52-week extension study after being successfully stabilized with one of 2 doses of aripiprazole lauroxil (441 or 882 mg) in a pivotal 12-week, placebo-controlled, randomized clinical trial...
September 19, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28937620/dysbindin-1-involvement-in-the-etiology-of-schizophrenia
#4
REVIEW
Haitao Wang, Jiangping Xu, Philip Lazarovici, Wenhua Zheng
Schizophrenia is a major psychiatric disorder that afflicts about 1% of the world's population, falling into the top 10 medical disorders causing disability. Existing therapeutic strategies have had limited success on cognitive impairment and long-term disability and are burdened by side effects. Although new antipsychotic medications have been launched in the past decades, there has been a general lack of significant innovation. This lack of significant progress in the pharmacotherapy of schizophrenia is a reflection of the complexity and heterogeneity of the disease...
September 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28937546/a-randomized-nonblind-naturalistic-comparison-of-efficacy-and-cognitive-outcomes-with-right-unilateral-bifrontal-and-bitemporal-electroconvulsive-therapy-in-schizophrenia
#5
Aniket Bansod, Sushma S Sonavane, Nilesh B Shah, Avinash A De Sousa, Chittaranjan Andrade
BACKGROUND: There is little literature on the relative efficacy and cognitive safety of right unilateral (RUL), bifrontal (BF), and bitemporal (BT) electroconvulsive therapy (ECT) in schizophrenia. METHODS: We present a randomized, nonblind, naturalist comparison of a fixed course of 8 moderately high-dose RUL (n = 24), threshold BF (n = 27), and threshold BT (n = 31) ECT in patients with schizophrenia. Assessments included the Positive and Negative Syndrome Scale (PANSS), the Wechsler Memory Scale-Revised, and an autobiographical memory interview...
September 20, 2017: Journal of ECT
https://www.readbyqxmd.com/read/28936820/-efficacy-of-low-dose-aripiprazole-to-treat-clozapine-associated-tardive-dystonia-in-a-patient-with-schizophrenia
#6
Lyang Huh, Bong Ju Lee
Tardive dystonia (TDt) is a debilitating side effect of long-term antipsychotic treatment. Even though TDt is associated with increased psychiatric morbidity, mortality, and severely decreased quality of life, there are no treatment modalities for TDt. Clozapine has been used as a treatment option for TDt in patients with schizophrenia. Interestingly, several recent case reports have indicated that it can enhance or induce TDt. We report a case of clozapine-associated TDt that was treated with low-dose aripiprazole (0...
2017: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
https://www.readbyqxmd.com/read/28936815/-current-clinical-variables-in-schizophrenia-cases-with-suicide-attempt-history
#7
Demet Sağlam Aykut, Filiz Civil Arslan, Evrim Özkorumak Karagüzel, Serdar Karakullukçu, Ahmet Tiryaki
OBJECTIVE: High suicide risk was shown to be related with depression and low quality of life in studies investigating clinical variables related to suicidal behavior. The aim of this study was to investigate the effects of a suicide attempt on clinical presentation by comparing sociodemographic variables, clinical signs, symptoms of depression, quality of life, social functionality, and reported adverse drug reactions in schizophrenic patients with and without suicide. METHOD: Positive and Negative Syndrome Scale (PANSS), Calgary Depression Scale (CDS), Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q), Social Functioning Scale (SFS), and Udvalg for Kliniske Undersøgelser Side Effect Rating Scale (UKU) were administered to 115 patients with schizophrenia...
2017: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
https://www.readbyqxmd.com/read/28936707/immunoglobulin-genotypes-and-cognitive-functions-in-schizophrenia
#8
Janardan P Pandey, Aryan M Namboodiri, Paul J Nietert, Reiji Yoshimura, Hikaru Hori
Exposure to neurotropic viruses, such as herpes simplex virus type 1 and human cytomegalovirus, has been reported to be associated with cognitive impairment in schizophrenia. These viruses have evolved highly sophisticated strategies for decreasing the efficacy of the host immune response and interfering with viral clearance. Particular immunoglobulin GM (γ marker) genotypes modulate these viral immunoevasion strategies, influence antibody responsiveness to viral proteins, and are also associated with susceptibility to schizophrenia, providing an excellent rationale for determining their possible involvement in the cognitive functions in this highly heritable neurodevelopmental disorder...
September 22, 2017: Immunogenetics
https://www.readbyqxmd.com/read/28936548/auditory-feature-perception-and-auditory-hallucinatory-experiences-in-schizophrenia-spectrum-disorder
#9
Ashley M Schnakenberg Martin, Lisa Bartolomeo, Josselyn Howell, William P Hetrick, Amanda R Bolbecker, Alan Breier, Gary Kidd, Brian F O'Donnell
Schizophrenia spectrum disorder (SZ) is associated with deficits in auditory perception as well as auditory verbal hallucinations (AVH). However, the relationship between auditory feature perception and auditory verbal hallucinations (AVH), one of the most commonly occurring symptoms in psychosis, has not been well characterized. This study evaluated perception of a broad range of auditory features in SZ and determined whether current AVHs relate to auditory feature perception. Auditory perception, including frequency, intensity, duration, pulse-train and temporal order discrimination, as well as an embedded tone task, was assessed in both AVH (n = 20) and non-AVH (n = 24) SZ individuals and in healthy controls (n = 29) with the Test of Basic Auditory Capabilities (TBAC)...
September 21, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28936170/affective-processing-in-non-invasive-brain-stimulation-over-prefrontal-cortex
#10
REVIEW
Wei Liu, Ya Shu Leng, Xiao Han Zou, Zi Qian Cheng, Wei Yang, Bing Jin Li
The prefrontal cortex (PFC) is the most frequently targeted brain region by non-invasive brain stimulation (NBS) studies. Non-invasively stimulating the PFC has been shown to both modulate affective processing and improve the clinical symptoms of several psychiatric disorders, such as depression and schizophrenia. The magnitude of the modulation depends on several factors, including the stimulation frequency, the number of stimulation sessions, and the specific sub-region of the PFC that is stimulated. Although some of the potential underlying mechanisms have been identified, the exact mechanisms that underlie these cognitive and affective changes remain unclear...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28936160/the-energy-metabolism-dysfunction-in-psychiatric-disorders-postmortem-brains-focus-on-proteomic-evidence
#11
REVIEW
Giuliana S Zuccoli, Verônica M Saia-Cereda, Juliana M Nascimento, Daniel Martins-de-Souza
Psychiatric disorders represent a great medical and social challenge and people suffering from these conditions face many impairments regarding personal and professional life. In addition, a mental disorder will manifest itself in approximately one quarter of the world's population at some period of their life. Dysfunction in energy metabolism is one of the most consistent scientific findings associated with these disorders. With this is mind, this review compiled data on disturbances in energy metabolism found by proteomic analyses of postmortem brains collected from patients affected by the most prevalent psychiatric disorders: schizophrenia (SCZ), bipolar disorder (BPD), and major depressive disorder (MDD)...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28936154/potential-role-of-amino-acids-in-pathogenesis-of-schizophrenia
#12
REVIEW
Shamaila Saleem, Faiza Shaukat, Anjuman Gul, Mahwish Arooj, Arif Malik
Schizophrenia is a syndrome of inconclusive etiopathogenesis with a prevalence of about 1% in general population. Underlying factors include genetic predisposition and defected neurodevelopment in early stages of life. The role of amino acids has been indicated in some reports. However, very few workers have detailed the effect of each amino acid in the pathophysiology of schizophrenia. Thus, in the present review, we aimed to provide an insight into the potential role of amino acids levels during schizophrenia...
July 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/28936008/physical-activity-diminishes-symptomatic-decline-in-chronic-schizophrenia-a-systematic-review
#13
Sandip P Tarpada, Matthew T Morris
Physical activity has been shown to positively influence a number of parameters in chronic schizophrenia, including cognition, social well being, and quality of life. Here, we present a systematic review of randomized controlled trials reporting on reduction of positive and negative symptoms using PANSS grading after the implementation of a physical activity protocol. Review of 64 articles yielded 6 relevant to our discussion. We found that physical activity significantly improved aggregate total PANSS score as well as positive symptoms PANSS score...
September 15, 2017: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/28936007/a-phase-1-open-label-single-dose-pharmacokinetic-study-in-stabilized-patients-with-schizophrenia-following-risperidone-implant
#14
Ryan Dammerman, Sonnie Kim, Mathews Adera, Alex Schwarz
No abstract text is available yet for this article.
September 15, 2017: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/28936006/a-phase-1-6-month-open-label-dose-ranging-pharmacokinetic-study-in-stabilized-patients-with-schizophrenia-following-risperidone-implant
#15
Ryan Dammerman, Sonnie Kim, Mathews Adera, Alex Schwarz
No abstract text is available yet for this article.
September 15, 2017: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/28935880/the-role-of-glutamate-transporters-in-the-pathophysiology-of-neuropsychiatric-disorders
#16
REVIEW
Sinead M O'Donovan, Courtney R Sullivan, Robert E McCullumsmith
Altered glutamate transporter expression is a common feature of many neuropsychiatric conditions, including schizophrenia. Excitatory amino acid transporters (EAATs) are responsible for the reuptake of glutamate, preventing non-physiological spillover from the synapse. Postmortem studies have revealed significant dysregulation of EAAT expression in various brain regions at the cellular and subcellular level. Recent animal studies have also demonstrated a role for glutamate spillover as a mechanism of disease...
September 21, 2017: NPJ Schizophrenia
https://www.readbyqxmd.com/read/28935586/impairment-of-neural-coordination-in-hippocampal-neuronal-ensembles-after-a-psychotomimetic-dose-of-dizocilpine
#17
Ewa Szczurowska, Nikhil Ahuja, Přemysl Jiruška, Eduard Kelemen, Aleš Stuchlík
The discoordination hypothesis of schizophrenia posits discoordination of neural activity as the central mechanism that underlies some psychotic symptoms (including 'hallmark' cognitive symptoms) of schizophrenia. To test this proposition, we studied the activity of hippocampal neurons in urethane anesthetized Long Evans rats after 0.15mg/kg dizocilpine (MK-801), an N-Methyl-d-aspartate (NMDA) glutamate receptor antagonist, which can cause psychotic symptoms in humans and cognitive control impairments in animals...
September 18, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28935216/allosteric-modulators-targeting-cns-muscarinic-receptors
#18
REVIEW
Andreas Bock, Ramona Schrage, Klaus Mohr
Muscarinic acetylcholine receptors are G protein-coupled receptors (GPCRs) which are broadly expressed in the central nervous system (CNS) and other tissues in the periphery. They emerge as important drug targets for a number of diseases including Alzheimer's disease, Parkinson's disease, and schizophrenia. Muscarinic receptors are divided into five subtypes (M1-M5) of which M1-M4 have been crystalized. All subtypes possess at least one allosteric binding site which is located in the extracellular region of the receptor on top of the ACh (i...
September 18, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28935169/deficient-single-item-maintenance-following-intact-updating-in-schizophrenia
#19
Tarra Combs, Jarett E Roseberry, Leah H Rubin, S Kristian Hill
No abstract text is available yet for this article.
September 18, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28934990/x-linked-ichthyosis-associated-with-psychosis-and-behavioral-abnormalities-a-case-report
#20
Amna Malik, Ahmed Bait Amer, Mohammed Salama, Bander Haddad, Muhammad T Alrifai, Mohammed Al Balwi, William Davies, Wafaa Eyaid
BACKGROUND: X-linked ichthyosis is a dermatological condition caused by deficiency for the enzyme steroid sulfatase. Previously, X-linked ichthyosis/steroid sulfatase deficiency has been associated with developmental and neurological phenotypes. Here, we show for the first time, that X-linked ichthyosis may be comorbid with an additional psychiatric phenotype (psychosis). CASE PRESENTATION: We report the case of an 11-year-old Saudi Arabian boy with X-linked ichthyosis associated with psychosis, mental retardation, autism spectrum disorder, inattentive attention deficit hyperactivity disorder, and epilepsy...
September 22, 2017: Journal of Medical Case Reports
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