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https://www.readbyqxmd.com/read/27474824/help-desk-answers-do-novel-oral-anticoagulants-safely-prevent-stroke-in-patients-with-nonvalvular-a-fib
#1
Ryan Siewert, Jeff Hostetter
Yes. Dabigatran, rivaroxaban, and apixaban are safe and effective compared with warfarin for preventing stroke in patients with nonvalvular atrial fibrillation. These novel oral anticoagulants (NOACs) are noninferior in reducing the number of strokes and systemic emboli and in lowering all-cause mortality while not increasing major bleeding complications and hemorrhagic events.
June 2016: Journal of Family Practice
https://www.readbyqxmd.com/read/27164554/residential-exposure-to-traffic-noise-and-risk-of-incident-atrial-fibrillation-a-cohort-study
#2
Maria Monrad, Ahmad Sajadieh, Jeppe Schultz Christensen, Matthias Ketzel, Ole Raaschou-Nielsen, Anne Tjønneland, Kim Overvad, Steffen Loft, Mette Sørensen
BACKGROUND: Studies have found long-term exposure to traffic noise to be associated with higher risk for hypertension, ischemic heart disease and stroke. We aimed to investigate the novel hypothesis that traffic noise increases the risk of atrial fibrillation (A-fib). METHODS: In a population-based cohort of 57,053 people aged 50-64years at enrolment in 1993-1997, we identified 2692 cases of first-ever hospital admission of A-fib from enrolment to end of follow-up in 2011 using a nationwide registry...
July 2016: Environment International
https://www.readbyqxmd.com/read/26606741/free-fatty-acid-as-an-outcome-predictor-of-atrial-fibrillation-associated-stroke
#3
Jeong-Yoon Choi, Jin-Man Jung, Do-Young Kwon, Moon Ho Park, Ji Hyun Kim, Kyungmi Oh, Seong-Beom Koh, Woo-Keun Seo
OBJECTIVE: We investigated whether baseline plasma free fatty acid (FFA) concentration is associated with any (ischemic/hemorrhagic) stroke, ischemic stroke/systemic embolism (ISSE), or ischemic stroke among stroke survivors with atrial fibrillation (A-fib). Moreover, we compared the outcome predictability of FFA with previously adopted models, including the CHADS2 and CHA2 DS2 -VASc scoring systems. METHODS: We analyzed data from 279 stroke patients with A-fib and investigated the association between plasma FFA concentration and outcomes using Cox regression models with competing risk analyses...
February 2016: Annals of Neurology
https://www.readbyqxmd.com/read/25695414/updates-in-antiarrhythmic-therapy-for-atrial-fibrillation-in-geriatric-patients
#4
REVIEW
Cassandra Ehrlich, Laura V Tsu
OBJECTIVE: To provide a review of the current evidence for the use of antiarrhythmic therapy in the geriatric population. DATA SOURCES: A PubMed search of articles in the English language published from 1990 through August 2014 was performed using a combination of the following words: amiodarone, antiarrhythmic, atrial fibrillation, dofetilide, dronedarone, elderly, flecainide, geriatric, propafenone, sotalol. STUDY SELECTION/DATA EXTRACTION: Relevant original studies, review articles, and guidelines were assessed for use of antiarrhythmic therapy to manage atrial fibrillation (A fib) in the elderly...
February 2015: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/25203108/use-of-onabotulinumtoxina-for-overactive-bladder-with-concomitant-warfarin
#5
Golden L Peters, Scott Martin Vouri
The symptoms of overactive bladder (OAB) can be treated with oral medications using a variety of antimuscarinic medications and, more recently, mirabegron, a beta-3 agonist. However, the use of these medications may be limited for patients because of adverse drug reactions, contraindications, and those who are refractory to oral medications. Recently, intravesical injections of onabotulinumtoxinA (onaBoNTA) have been proven to be safe and effective as an alternative to oral OAB medications. Although this procedure is typically thought to be outside the realm of a consultant pharmacist, there are incidences in which a pharmacist can make a substantial impact on patient care...
July 2014: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/24888793/presentation-of-atrial-fibrillation-following-oral-dexamethasone-treatment-in-a-nf2-patient
#6
Andrea L O Hebb, Syed Ali Imran, David P Morris, Manohar Bance, Simon Walling
Atrial fibrillation (A-fib) is the most common cardiac arrhythmia which is associated with an increased risk of mortality secondary to stroke and coronary artery disease. Intravenous glucocorticoid therapy (such as dexamethasone and hydrocortisone) is frequently used peri-operatively in patients undergoing cardiac surgery to prevent A-fib. Dexamethasone is also frequently used in patients with single or bilateral vestibular schwannomas (VS), to reduce tumor swelling both before and after radiation treatment...
September 2014: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/24381332/improved-sedation-with-dexmedetomidine-remifentanil-compared-with-midazolam-remifentanil-during-catheter-ablation-of-atrial-fibrillation-a-randomized-controlled-trial
#7
RANDOMIZED CONTROLLED TRIAL
Jin Sun Cho, Jae-Kwang Shim, Sungwon Na, Inhye Park, Young Lan Kwak
AIMS: Anaesthesia is required for catheter ablation of atrial fibrillation (A-fib) to achieve patient comfort and immobilization to avoid map shifts. This study compared the analgesic and sedative efficacies of dexmedetomidine-remifentanil with those of midazolam-remifentanil for catheter ablation of A-fib. METHODS AND RESULTS: Ninety patients were randomized to receive either intermittent midazolam boluses (1-2 mg) with 3.6-7.2 µg/kg/h of remifentanil (MR group) or dexmedetomidine 0...
July 2014: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/23421535/adjunctive-renal-sympathetic-denervation-to-modify-hypertension-as-upstream-therapy-in-the-treatment-of-atrial-fibrillation-h-fib-study-clinical-background-and-study-design
#8
RANDOMIZED CONTROLLED TRIAL
Humera Ahmed, Marc A Miller, Srinivas R Dukkipati, Sam Cammack, Jacob S Koruth, Sandeep Gangireddy, Betsy A Ellsworth, Andre D'Avila, Michael Domanski, Annetine C Gelijns, Alan Moskowitz, Vivek Y Reddy
BACKGROUND: Hypertension is the most important risk factor directly attributable to the high prevalence of atrial fibrillation (AF), and is one of the few modifiable risk factors for AF. Activation and overactivity of the sympathetic nervous system (SNS) have been implicated in the pathogenesis of both essential hypertension and AF. Catheter-based renal sympathetic denervation (RSDN) appears to be an effective adjunctive treatment for refractory hypertension, and may be beneficial in other conditions characterized by SNS overactivity, such as left ventricular hypertrophy and atrial arrhythmias...
May 2013: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/22906898/introduction-antiplatelet-therapy-in-acs-and-a-fib
#9
EDITORIAL
Victor L Serebruany, Dan Atar
No abstract text is available yet for this article.
2012: Advances in Cardiology
https://www.readbyqxmd.com/read/22445865/potential-negative-effects-of-epinephrine-on-carotid-blood-flow-and-etco2-during-active-compression-decompression-cpr-utilizing-an-impedance-threshold-device
#10
Aaron M Burnett, Nicolas Segal, Joshua G Salzman, M Scott McKnite, Ralph J Frascone
OBJECTIVES: This study examines the effects of IV epinephrine administration on carotid blood flow (CBF) and end tidal CO(2) (ETCO(2)) production in a swine model of active compression-decompression CPR with an impedance threshold device (ACD-CPR+ITD). METHODS: Six female swine (32 ± 1 kg) were anesthetized, intubated and ventilated. Intracranial, thoracic aorta and right atrial pressures were measured via indwelling catheters. CBF was recorded. ETCO(2), SpO(2) and EKG were monitored...
August 2012: Resuscitation
https://www.readbyqxmd.com/read/22255459/detection-of-atrial-fibrillation-from-non-episodic-ecg-data-a-review-of-methods
#11
REVIEW
Sujit Kumar Sahoo, Wenmiao Lu, Sintiani Dewi Teddy, Desok Kim, Mengling Feng
Atrial fibrillation (A-fib) is the most common cardiac arrhythmia. To effectively treat or prevent A-fib, automatic A-fib detection based on Electrocardiograph (ECG) monitoring is highly desirable. This paper reviews recently developed techniques for A-fib detection based on non-episodic surface ECG monitoring data. A-fib detection methods in the literature can be mainly classified into three categories: (1) time domain methods; (2) frequency domain methods; and (3) non-linear methods. In general the performances of these methods were evaluated in terms of sensitivity, specificity and overall detection accuracy on the datasets from the Physionet repository...
2011: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/21867988/long-term-clinical-impact-of-functional-mitral-regurgitation-after-aortic-valve-replacement
#12
COMPARATIVE STUDY
Dong Seop Jeong, Pyo Won Park, Kiick Sung, Wook Sung Kim, Ji-Hyuk Yang, Tae-Gook Jun, Young Tak Lee
BACKGROUND: We evaluated the impact of functional mitral regurgitation (MR) on clinical outcomes and to identify predictors of residual MR after aortic valve replacement in aortic stenosis. METHODS: Three hundred and eighty-four patients who underwent primary aortic valve replacement for aortic stenosis were enrolled. Patients were divided into the no-MR group (no or trivial MR; n = 270) and the MR group (mild to moderate MR; n = 114). In the MR group, 19 patients underwent concomitant mitral valve repairs...
October 2011: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/21266775/defective-tbx2-dependent-patterning-of-the-atrioventricular-canal-myocardium-causes-accessory-pathway-formation-in-mice
#13
Wim T J Aanhaanen, Bastiaan J D Boukens, Aleksander Sizarov, Vincent Wakker, Corrie de Gier-de Vries, Antoni C van Ginneken, Antoon F M Moorman, Ruben Coronel, Vincent M Christoffels
Ventricular preexcitation, a feature of Wolff-Parkinson-White syndrome, is caused by accessory myocardial pathways that bypass the annulus fibrosus. This condition increases the risk of atrioventricular tachycardia and, in the presence of atrial fibrillation, sudden death. The developmental mechanisms underlying accessory pathway formation are poorly understood but are thought to primarily involve malformation of the annulus fibrosus. Before birth, slowly conducting atrioventricular myocardium causes a functional atrioventricular activation delay in the absence of the annulus fibrosus...
February 2011: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/20714452/purls-a-fib-and-rate-control-don-t-go-too-low
#14
Kristen Deane, Kohar Jones, James J Stevermer
For patients with atrial fibrillation, more relaxed heart rate control is as effective as stricter control but, with fewer adverse effects.
August 2010: Journal of Family Practice
https://www.readbyqxmd.com/read/20345495/new-approaches-to-atrial-fibrillation-management-treat-the-patient-not-the-ecg
#15
REVIEW
Arnold Pinter, Paul Dorian
Atrial fibrillation causes a significant burden on patients and the health care system. The main goals of atrial fibrillation therapy are to improve symptoms and reduce morbidity. There have been significant recent developments in both stoke prophylaxis and rhythm/rate control. The results of the ACTIVE W study emphasize the importance of effective oral anticoagulant therapy in patients with moderate-to-high risk for stroke. The RE-LY study showed superiority of dabigatran, an oral direct thrombin inhibitor, over warfarin in the prevention of stroke, or systemic embolism...
October 2010: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/20204641/imaging-of-pulmonary-vein-anatomy-using-low-dose-prospective-ecg-triggered-dual-source-computed-tomography
#16
Philipp Blanke, Tobias Baumann, Mathias Langer, Gregor Pache
OBJECTIVE: To prospectively investigate the feasibility, image quality and radiation dose estimates for computed tomography angiography (CTA) of the pulmonary veins and left atrium using prospective electrocardiography (ECG)-triggered sequential dual-source (DS) data acquisition at end-systole in patients with paroxysmal atrial fibrillation undergoing radiofrequency ablation. METHODS: Thirty-five patients (mean age 66.2 +/- 12.6 years) with paroxysmal atrial fibrillation underwent prospective ECG-triggered sequential DS-CTA with tube current (250 mAs/rotation) centred 250 ms past the R-peak...
August 2010: European Radiology
https://www.readbyqxmd.com/read/20165567/stroke-prevention-the-best-outcome-after-a-transient-ischemic-attack-results-from-the-minnesota-stroke-registry-and-opportunities-to-improve-care
#17
Silvina B Tonarelli, Gabriela Vazquez, James M Peacock, Russell V Luepker, Albert W Tsai, Haralabos Zacharatos, Kamakshi Lakshminarayan
A transient ischemic attack (TIA) is an opportunity for stroke prevention. We examined the care of 708 TIA patients entered into the Minnesota Stroke Registry (MSR) and analyzed the extent to which they were discharged on appropriate guideline-recommended secondary prevention treatments. We calculated the overall number of strokes prevented by multiple risk factor modifying treatments. Of the 708 TIA patients, 533 (75%) were discharged on antihypertensive treatment. Of 208 patients with an LDL-Cholesterol greater than 100 mg/dl, 131 (63%) patients were prescribed lipid-lowering medications...
January 1, 2008: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/19262444/aniticoagulation-in-patients-following-prosthetic-heart-valve-replacement
#18
Raja Parvez Akhtar, Abdul Rehman Abid, Hasnain Zafar, Jawad Sajid Khan
PURPOSE: To identify optimum international normalized ratio (INR) levels and required warfarin doses and anticoagulation-related complications in patients following mechanical prosthetic valve replacement. MATERIALS AND METHODS: Five hundred and seven patients were prospectively followed up for 10 years (2008.5 patient-years). Anticoagulation-related complications were classified into hemorrhage and thromboembolism. RESULTS: Two hundred and ninety-two (57...
February 2009: Annals of Thoracic and Cardiovascular Surgery
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