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https://www.readbyqxmd.com/read/29150898/a-model-to-characterize-psychopathological-features-in-adults-with-prader-willi-syndrome
#1
Denise Thuilleaux, Virginie Laurier, Pierre Copet, Julie Tricot, Geneviève Demeer, Fabien Mourre, Maithé Tauber, Joseba Jauregi
High prevalence of behavioral and psychiatric disorders in adults with Prader-Willi Syndrome (PWS) has been reported in last few years. However, data are confusing and often contradictory. In this article, we propose a model to achieve a better understanding of the psychopathological features in adults with PWS. The study is based on clinical observations of 150 adult inpatients, males and females. Non-parametric statistics were performed to analyse the association of psychopathological profiles with genotype, gender and age...
November 17, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29143717/white-matter-abnormalities-in-22q11-2-deletion-syndrome-patients-showing-cognitive-decline
#2
Jasper Olivier Nuninga, Marc Marijn Bohlken, Sanne Koops, Ania M Fiksinski, René C W Mandl, Elemi J Breetvelt, Sasja N Duijff, René S Kahn, Iris E C Sommer, Jacob A S Vorstman
BACKGROUND: Decline in cognitive functioning precedes the first psychotic episode in the course of schizophrenia and is considered a hallmark symptom of the disorder. Given the low incidence of schizophrenia, it remains a challenge to investigate whether cognitive decline coincides with disease-related changes in brain structure, such as white matter abnormalities. The 22q11.2 deletion syndrome (22q11DS) is an appealing model in this context, as 25% of patients develop psychosis. Furthermore, we recently showed that cognitive decline also precedes the onset of psychosis in individuals with 22q11DS...
November 16, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/29143456/early-intervention-in-psychosis-from-clinical-intervention-to-health-system-implementation
#3
Claudio Csillag, Merete Nordentoft, Masafumi Mizuno, David McDaid, Celso Arango, Jo Smith, Antonio Lora, Swapna Verma, Teresa Di Fiandra, Peter B Jones
AIM: Early intervention in psychosis (EIP) is a well-established approach with the intention of early detection and treatment of psychotic disorders. Its clinical and economic benefits are well documented. This paper presents basic aspects of EIP services, discusses challenges to their implementation and presents ideas and strategies to overcome some of these obstacles. METHODS: This paper is a narrative review about the evidence supporting EIP, with examples of successful implementation of EIP and of cases where major obstacles still need to be overcome...
November 16, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29141785/environmental-adversities-and-psychotic-symptoms-the-impact-of-timing-of-trauma-abuse-and-neglect
#4
Inga Schalinski, Susanne Breinlinger, Vanessa Hirt, Martin H Teicher, Michael Odenwald, Brigitte Rockstroh
BACKGROUND: Trauma and adverse childhood experiences (ACE) occur more often in mental illness, including psychosis, than in the general population. Individuals with psychosis (cases) report a higher number and severity (dose) of adversities than healthy controls. While a dose-dependent increase of adversities has been related to more severe psychopathology, the role of type and timing is still insufficiently understood on the exacerbation of positive and negative psychotic symptoms. Moreover, dissociative symptoms were examined as potential mediator between adversities and severity of psychotic symptoms...
November 13, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29141491/association-of-psychosis-affective-disorders-and-diseases-affecting-the-immune-system
#5
Jeanette Brun Larsen, Valentina Cabral Iversen, Solveig Klæbo Reitan
Purpose of the article: There are indications of altered immune activity in depressed and psychotic patients compared to healthy controls in several studies. To explore the clinical importance of this phenomenon we examined the relation between different disorders affecting the immune system and psychoses and depression, respectively. MATERIALS AND METHODS: A total of 276 patients consecutively admitted to a psychiatric acute ward were included in the study. Of these 41 patients fulfilled the criteria for ICD-10 F20-29 (psychotic) diagnosis and 157 patients a F30-39 (affective) diagnosis...
November 16, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/29141125/elevated-proinflammatory-markers-in-22q11-2-deletion-syndrome-are-associated-with-psychosis-and-cognitive-deficits
#6
Ehud Mekori-Domachevsky, Michal Taler, Yehuda Shoenfeld, Michael Gurevich, Polina Sonis, Omri Weisman, Abraham Weizman, Doron Gothelf
OBJECTIVE: 22q11.2 deletion syndrome (22q11.2DS) is a neurogenetic disorder whose phenotype includes high rates of a schizophrenia-like psychotic disorder and immune system abnormalities. Thus, 22q11.2DS is an ideal model for studying the relationship between psychosis and inflammation. The aim of the present study was to identify inflammatory markers that may play a role in the pathophysiologic pathways associated with psychosis and cognitive deficits in 22q11.2DS. METHODS: Forty-nine individuals with 22q11...
November 14, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29134852/psychosis-and-sexual-offending-a-review-of-current-literature
#7
E Thomas Lewis, R Gregg Dwyer
Sexual offending is a public health concern and societal risk requiring a multi-disciplinary approach. While current data give an indication of the frequency of sexual victimization, these figures likely underestimate the severity of the concern as many of these incidents go unreported. And while sex offender research has increased over the past several decades, particular attention to those offenders with severe mental illness remains limited. In this descriptive review, literature describing sex offenders with psychotic disorders is explored with a focus on recent research...
November 1, 2017: International Journal of Offender Therapy and Comparative Criminology
https://www.readbyqxmd.com/read/29134233/-genuine-motor-phenomena-in-schizophrenia-neuronal-correlates-and-pathomechanisms
#8
REVIEW
D Hirjak, G Northoff, P A Thomann, K M Kubera, R C Wolf
Despite a growing body of evidence on motor dysfunction in schizophrenia spectrum disorders, the neuronal correlates of genuine motor abnormalities (GMA) are not fully elucidated at present. Moreover, the clinical relevance of a potential "motor intermediate phenotype" remains controversial. This systematic review aims at characterizing a "motor intermediate phenotype" in schizophrenia spectrum disorders. The second goal of this systematic review is to discuss GMA-associated brain alterations as potential biomarkers of psychosis risk syndrome and manifest motor symptoms against the background of current neuroimaging evidence...
November 13, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/29132815/impaired-mismatch-negativity-to-frequency-deviants-in-individuals-at-ultra-high-risk-for-psychosis-and-preliminary-evidence-for-further-impairment-with-transition-to-psychosis
#9
Suzie Lavoie, Bradley N Jack, Oren Griffiths, Ayaka Ando, Paul Amminger, Anthony Couroupis, Aidan Jago, Connie Markulev, Patrick D McGorry, Barnaby Nelson, Andrea Polari, Hok Pan Yuen, Thomas J Whitford
BACKGROUND: There is evidence to suggest that people with established psychotic disorders show impairments in the mismatch negativity induced by a frequency-deviant sound (fMMN), and that these impairments worsen with the deterioration of psychotic symptoms. This study aimed to test whether individuals at ultra-high risk (UHR) for psychosis show pre-morbid impairments in fMMN, and if so, whether fMMN continues to deteriorate with transition to psychosis. METHOD: fMMN was recorded in a cohort of UHR individuals (n=42) and compared to healthy controls (n=29)...
November 10, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29132271/capgras-syndrome-in-advanced-parkinson-s-disease
#10
Christopher L Groth, Antonia Pusso, Scott A Sperling, Diane S Huss, W Jeffrey Elias, G Frederick Wooten, Matthew J Barrett
Psychosis is common in Parkinson's disease (PD), especially in advanced disease, and can lead to a number of psychotic symptoms, including delusions. One uncommon delusion is Capgras syndrome (CS). The authors report on three PD patients with a history of deep brain stimulation (DBS) who developed this delusion. The anatomic targets in these three patients were the subthalamic nuclei in two patients and the globus pallidus interna in one patient. The length of time between surgery and development of CS varied but was greater than 6 months...
November 14, 2017: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/29129510/increase-in-serum-hdl-level-is-associated-with-less-negative-symptoms-after-one-year-of-antipsychotic-treatment-in-first-episode-psychosis
#11
Priyanthi B Gjerde, Ingrid Dieset, Carmen Simonsen, Eva Z Hoseth, Trude Iversen, Trine V Lagerberg, Siv Hege Lyngstad, Ragni H Mørch, Silje Skrede, Ole A Andreassen, Ingrid Melle, Vidar M Steen
BACKGROUND: A potential link between increase in total cholesterol and triglycerides and clinical improvement has been observed during antipsychotic drug treatment in chronic schizophrenia patients, possibly due to drug related effects on lipid biosynthesis. We examined whether changes in serum lipids are associated with alleviation of psychosis symptoms after one year of antipsychotic drug treatment in a cohort of first-episode psychosis (FEP) patients. METHODS: A total of 132 non-affective antipsychotic-treated FEP patients were included through the Norwegian Thematically Organized Psychosis (TOP) project...
November 9, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29128195/-what-support-of-young-presenting-a-first-psychotic-episode-when-schooling-is-being-challenged
#12
M-N Vacheron, H Veyrat-Masson, E Wehbe
Psychiatric disorders (more specifically mood disorders and psychosis) represent the 1st cause of disability among young people. Unemployment rate between 75 to 95% for the person with schizophrenia. It is correlated to poor social integration and bad economic status, worse symptomatology loss of autonomy as well as global bad functioning. It is responsible of more than half of the overall cost of psychosis. The onset of most of psychiatric disorders occur between the age of 25 and 35 years old, a critical time in young adult life when they should build their professional as well as social future...
November 8, 2017: L'Encéphale
https://www.readbyqxmd.com/read/29121974/a-randomised-double-blind-placebo-controlled-trial-of-minocycline-and-or-omega-3-fatty-acids-added-to-treatment-as-usual-for-at-risk-mental-states-nayab-study-protocol
#13
Inti Qurashi, Imran B Chaudhry, Ameer B Khoso, Sana Farooque, Steve Lane, Mohammad Omair Husain, Simon Chu, Jane Sarginson, Munir Hamarani, Haider A Naqvi, Bushra Razzaque, Fareed A Minhas, Alison R Yung, J F W Deakin, Nusrat Husain
BACKGROUND: The at-risk mental state (ARMS) describes individuals at high risk of developing schizophrenia or psychosis. The use of antipsychotics in this population is not supported, because most individuals with ARMS are unlikely to develop psychosis. Anti-inflammatory treatments and polyunsaturated fatty acids (PUFAs) may have some beneficial effects in the treatment of ARMS. There have been no controlled clinical trials in which researchers have investigated the use of minocycline for ARMS and no trials involving PUFAs in combination with other proposed treatments...
November 9, 2017: Trials
https://www.readbyqxmd.com/read/29121595/from-the-psychosis-prodrome-to-the-first-episode-of-psychosis-no-evidence-of-a-cognitive-decline
#14
Ricardo E Carrión, Deborah J Walder, Andrea M Auther, Danielle McLaughlin, Heather O Zyla, Steven Adelsheim, Roderick Calkins, Cameron S Carter, Bentson McFarland, Ryan Melton, Tara Niendam, J Daniel Ragland, Tamara G Sale, Stephan F Taylor, William R McFarlane, Barbara A Cornblatt
Cognitive deficits have an important role in the neurodevelopment of schizophrenia and other psychotic disorders. However, there is a continuing debate as to whether cognitive impairments in the psychosis prodrome are stable predictors of eventual psychosis or undergo a decline due to the onset of psychosis. In the present study, to determine how cognition changes as illness emerges, we examined baseline neurocognitive performance in a large sample of helping-seeking youth ranging in clinical state from low-risk for psychosis through individuals at clinical high-risk (CHR) for illness to early first-episode patients (EFEP)...
October 19, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29120850/aggression-as-an-independent-entity-even-in-psychosis-the-role-of-cortisol
#15
Sourav Das, Soumik Sengupta, Kangkan Pathak, Divyashree Sah, Sumit Mehta, Priya Ranjan Avinash, Aparajeeta Baruah, Sailendra Kumar Deuri, Anil Sarmah, Vijay Gogoi, Kamal Narayan Kalita, Jyoti Hazarika
Aggression is a common entity in psychiatric disorders, particularly psychotic disorders. Glucocorticoid hypofunction has been linked to abnormal forms of aggressive behavior in various studies in a 'possibly causal' role. We hypothesise that aggression, even among those having psychosis is associated with glucocorticoid alterations similar to those who are aggressive but not psychotic. To our knowledge, this is the first study attempting to look at the cortisol functioning in relation to both aggression and psychosis...
November 8, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29120840/responsibility-beliefs-and-persecutory-delusions
#16
Katherine Pugh, Olga Luzon, Lyn Ellett
Recent research implicates cognitive processes traditionally linked to anxiety disorders in the maintenance of paranoia. Responsibility beliefs have traditionally been associated with OCD, and recent research suggests they may be transdiagnostic. The present study reports the first data on responsibility beliefs in individuals with persecutory delusions. 30 people with persecutory delusions completed measures of psychotic symptoms and responsibility beliefs. Participants were also asked to identify who they held responsible for their persecution...
November 2, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29120562/be-vigilant-for-dementia-in-parkinson%C3%A2-s-disease
#17
Flavia Niccolini, Konstantinos Diamantopoulos, Stelios Kiosses, Marios Politis
It is estimated that up to 80% of patients with Parkinson's disease will eventually develop cognitive impairment over the course of their illness. Even at the time of diagnosis, cognitive impairment has been reported in 20-25% of patients. Commonly affected cognitive domains are executive function, visuospatial ability and attention control. In addition, patients with Parkinson's disease dementia may present with deficits in language function and verbal memory. Psychosis may occur in approximately 40% of patients with Parkinson's disease, and is associated with an increased risk of developing cognitive impairment...
May 2017: Practitioner
https://www.readbyqxmd.com/read/29118723/inflammation-stress-response-and-redox-dysregulation-biomarkers-clinical-outcomes-and-pharmacological-implications-for-psychosis
#18
REVIEW
Stefania Schiavone, Luigia Trabace
In recent years, several studies claiming the finding of a specific biomarker for the identification of the "high-risk state" to develop psychosis, first psychotic episode, as well as the prediction of the individual response to antipsychotics have been published. Together with genetic reports, numerous publications in this field have been focused on inflammation and stress response blood biomarkers, as well as on indicators of redox dysregulation. In this review, we focus on human studies found in PubMed from January 1(st) 2010 to January 31(st) 2017, describing the clinical use of these biomarkers to detect the "premorbid" psychotic state and early phases of the disease...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29117909/a-history-of-obstetric-complications-is-associated-with-the-risk-of-progression-from-an-at-risk-mental-state-to-psychosis
#19
Magdalena Kotlicka-Antczak, Agnieszka Pawełczyk, Tomasz Pawełczyk, Dominik Strzelecki, Natalia Żurner, Michał Seweryn Karbownik
OBJECTIVE: Clinical criteria for diagnosing Clinical High Risk for psychosis are now available. However, an understanding of the factors modulating the risk of subsequent development of frank psychosis in "at risk" individuals remains elusive. The aim of the study was to identify associations between obstetric history and the development of psychotic disorders in individuals with an At Risk Mental State (ARMS). METHODS: Obstetric data was obtained from the medical records of 82 individuals meeting ARMS criteria...
November 5, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29117908/clinical-characteristics-of-primary-psychotic-disorders-with-concurrent-substance-abuse-and-substance-induced-psychotic-disorders-a-systematic-review
#20
Lorna Wilson, Attila Szigeti, Angela Kearney, Mary Clarke
BACKGROUND: Distinguishing between a primary psychotic disorder with concurrent substance abuse (PPD+SA) and a substance-induced psychotic disorder (SIPD) can be diagnostically challenging. We aimed to determine if these two diagnoses are clinically distinct, particularly in relation to psychopathology. In addition, we aimed to examine the specific clinical features of cannabis-induced psychotic disorder (CIPD) as compared to primary psychotic disorder with concurrent cannabis abuse (PPD+CA) and also to SIPD associated with any substance...
November 5, 2017: Schizophrenia Research
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