keyword
https://read.qxmd.com/read/38449006/clinical-characteristics-and-drug-resistance-of-nocardia-in-henan-china-2017-2023
#21
REVIEW
Yungang Han, Meijin Cheng, Zheng Li, Huihui Chen, Shuang Xia, Yue Zhao, Yali Wang, Wenyi He, Wei Wang
BACKGROUND: The aim of this study was to investigate the clinical features of Nocardia infections, antibiotic resistance profile, choice of antibiotics and treatment outcome, among others. In addition, the study compared the clinical and microbiological characteristics of nocardiosis in bronchiectasis patients and non-bronchiectasis patients. METHODS: Detailed clinical data were collected from the medical records of 71 non-duplicate nocardiosis patients from 2017 to 2023 at a tertiary hospital in Zhengzhou, China...
March 6, 2024: Annals of Clinical Microbiology and Antimicrobials
https://read.qxmd.com/read/38448186/-analysis-of-prognostic-factors-in-patients-with-covid-19-infection
#22
JOURNAL ARTICLE
H B Gao, J Zhang
The peak of COVID-19 infections in China has just passed, and symptomatic manifestations in patients vary widely, with a minority experiencing severe morbidity and mortality. Early detection of adverse outcomes remains critical for clinical governance and prognosis in COVID-19. This review synthesized both national and international studies relevant to the prognostic evaluation of COVID-19 and summarized the prognostic implications of demographics (age and gender), specific laboratory parameters, adjunctive examination results, complications, and comorbidities in COVID-19 patients...
March 12, 2024: Chinese Journal of Tuberculosis and Respiratory Diseases
https://read.qxmd.com/read/38448183/-research-status-of-glucagon-like-peptide-1-receptor-agonists-on-obstructive-sleep-apnea
#23
JOURNAL ARTICLE
B N Zhou, X Liu, K Hu
Obstructive sleep apnea (OSA) is the most common sleep-disordered breathing disease. Continuous positive airway pressure (CPAP) is the gold standard for treatment, but compliance is suboptimal. Therefore, new therapeutic strategies need to be explored. OSA is often associated with multiple comorbidities, particularly type 2 diabetes and obesity. Effective weight loss is known to be crucial in reversing OSA and its associated comorbidities. However, sustained weight loss is difficult to achieve with lifestyle changes alone...
March 12, 2024: Chinese Journal of Tuberculosis and Respiratory Diseases
https://read.qxmd.com/read/38442538/trends-of-type-2-diabetes-with-pulmonary-tuberculosis-patients-2013-2022-and-changes-after-the-coronavirus-disease-2019-covid-19-pandemic
#24
JOURNAL ARTICLE
Zijian Wang, Sheng Zhao, Aiping Zhang, Bin Quan, Chun Duan, Manman Liang, Janghua Yang
BACKGROUND: To describe the trends of Type 2 Diabetes with Pulmonary Tuberculosis (T2DM-TB) patients from 2013 to 2022 and to investigate the impact of COVID-19 lockdown on glycemic control and associated factors in T2DM-TB. METHODS: In this population-based study of the First Affiliated Yijishan Hospital of Wannan Medical College in China, we described the 10-year trends of patients diagnosed with T2DM-TB. We included patients diagnosed with TB, T2DM-TB and T2DM-TB patients for comparative analysis, aged 15 years or older...
February 27, 2024: Tuberculosis
https://read.qxmd.com/read/38440446/an-unusual-presentation-of-rhino-orbital-mucormycosis-with-mdr-tb-an-unforeseen-challenge-for-treatment-post-covid-19
#25
JOURNAL ARTICLE
Semridhi Gupta, Paridhi Ahuja, Ravi Jain
ROCM is an invasive fungal infection that has seen a substantial rise in the post covid-19 patients. Here we present an intriguing case of ROCM existing as a coinfection with MDR-TB. The purpose of this manuscript is to highlight the dilemma faced by the clinicians whether to take the risks associated with standard treatment protocols of mucormycosis contraindicated due to coexisting MDR-TB or to play safe and face the consequences of inadequate management.
February 2024: Indian Journal of Otolaryngology and Head and Neck Surgery
https://read.qxmd.com/read/38423021/effect-of-bcg-vaccination-against-mycobacterium-tuberculosis-infection-in-adult-brazilian-health-care-workers-a-nested-clinical-trial
#26
JOURNAL ARTICLE
Paulo Cesar Pereira Dos Santos, Nicole Louise Messina, Roberto Dias de Oliveira, Patricia Vieira da Silva, Marco Antonio Moreira Puga, Margareth Dalcolmo, Glauce Dos Santos, Marcus Vinícius Guimarães de Lacerda, Bruno Araújo Jardim, Fernando Fonseca de Almeida E Val, Nigel Curtis, Jason R Andrews, Julio Croda
BACKGROUND: The effectiveness of BCG vaccine for adult pulmonary tuberculosis remains uncertain. In this study, we aimed to evaluate the effect of vaccination with BCG-Denmark to prevent initial and sustained interferon-γ release assay conversion in Brazilian health-care workers. METHODS: This substudy is a nested randomised controlled trial embedded within the BRACE trial (NCT04327206). Specifically, this substudy enrolled Brazilian health-care workers (aged ≥18 years) from three sites in Brazil (Manaus, Campo Grande, and Rio de Janeiro) irrespective of previously receiving BCG vaccination...
February 26, 2024: Lancet Infectious Diseases
https://read.qxmd.com/read/38422092/tobacco-smoking-clusters-in-households-affected-by-tuberculosis-in-an-individual-participant-data-meta-analysis-of-national-tuberculosis-prevalence-surveys-time-for-household-wide-interventions
#27
JOURNAL ARTICLE
Yohhei Hamada, Matteo Quartagno, Irwin Law, Farihah Malik, Frank Adae Bonsu, Ifedayo M O Adetifa, Yaw Adusi-Poku, Umberto D'Alessandro, Adedapo Olufemi Bashorun, Vikarunnessa Begum, Dina Bisara Lolong, Tsolmon Boldoo, Themba Dlamini, Simon Donkor, Bintari Dwihardiani, Saidi Egwaga, Muhammad N Farid, Anna Marie Celina G Garfin, Donna Mae G Gaviola, Mohammad Mushtuq Husain, Farzana Ismail, Mugagga Kaggwa, Deus V Kamara, Samuel Kasozi, Kruger Kaswaswa, Bruce Kirenga, Eveline Klinkenberg, Zuweina Kondo, Adebola Lawanson, David Macheque, Ivan Manhiça, Llang Bridget Maama-Maime, Sayoki Mfinanga, Sizulu Moyo, James Mpunga, Thuli Mthiyane, Dyah Erti Mustikawati, Lindiwe Mvusi, Hoa Binh Nguyen, Hai Viet Nguyen, Lamria Pangaribuan, Philip Patrobas, Mahmudur Rahman, Mahbubur Rahman, Mohammed Sayeedur Rahman, Thato Raleting, Pandu Riono, Nunurai Ruswa, Elizeus Rutebemberwa, Mugabe Frank Rwabinumi, Mbazi Senkoro, Ahmad Raihan Sharif, Welile Sikhondze, Charalambos Sismanidis, Tugsdelger Sovd, Turyahabwe Stavia, Sabera Sultana, Oster Suriani, Albertina Martha Thomas, Kristina Tobing, Martie Van der Walt, Simon Walusimbi, Mohammad Mostafa Zaman, Katherine Floyd, Andrew Copas, Ibrahim Abubakar, Molebogeng X Rangaka
Tuberculosis (TB) and non-communicable diseases (NCD) share predisposing risk factors. TB-associated NCD might cluster within households affected with TB requiring shared prevention and care strategies. We conducted an individual participant data meta-analysis of national TB prevalence surveys to determine whether NCD cluster in members of households with TB. We identified eligible surveys that reported at least one NCD or NCD risk factor through the archive maintained by the World Health Organization and searching in Medline and Embase from 1 January 2000 to 10 August 2021, which was updated on 23 March 2023...
2024: PLOS Glob Public Health
https://read.qxmd.com/read/38401110/exploration-of-holistic-nursing-strategy-for-diabetic-patients-with-pulmonary-tuberculosis
#28
JOURNAL ARTICLE
Yamin Zhao, Wei Yuan, Fang Zhao, Jie Yang
OBJECTIVE: To explore the application effect of comprehensive nursing based on medical-care integration in diabetic patients with pulmonary tuberculosis. METHODS: 80 diabetic patients with pulmonary tuberculosis who were treated at Affiliated Hospital of Hebei University from March 2022 to March 2023 were randomly divided into the routine nursing group and the comprehensive nursing group. The routine nursing group received conventional nursing care, while the comprehensive nursing group received comprehensive nursing based on medical-care integration and routine care...
February 9, 2024: Alternative Therapies in Health and Medicine
https://read.qxmd.com/read/38399727/mutational-dynamics-related-to-antibiotic-resistance-in-m-tuberculosis-isolates-from-serial-samples-of-patients-with-tuberculosis-and-type-2-diabetes-mellitus
#29
JOURNAL ARTICLE
Gustavo A Bermúdez-Hernández, Damián Pérez-Martínez, Maria Cristina Ortiz-León, Raquel Muñiz-Salazar, Cuauhtemoc Licona-Cassani, Roberto Zenteno-Cuevas
Genetic variation in tuberculosis is influenced by the host environment, patients with comorbidity, and tuberculosis-type 2 diabetes mellitus (TB-T2DM) and implies a higher risk of treatment failure and development of drug resistance. Considering the above, this study aimed to evaluate the influence of T2DM on the dynamic of polymorphisms related to antibiotic resistance in TB. Fifty individuals with TB-T2DM and TB were initially characterized, and serial isolates of 29 of these individuals were recovered on day 0 (diagnosis), 30, and 60...
February 3, 2024: Microorganisms
https://read.qxmd.com/read/38399239/fixed-dose-combination-formulations-in-solid-oral-drug-therapy-advantages-limitations-and-design-features
#30
REVIEW
Christi A Wilkins, Hannlie Hamman, Josias H Hamman, Jan H Steenekamp
Whilst monotherapy is traditionally the preferred treatment starting point for chronic conditions such as hypertension and diabetes, other diseases require the use of multiple drugs (polytherapy) from the onset of treatment (e.g., human immunodeficiency virus acquired immunodeficiency syndrome, tuberculosis, and malaria). Successful treatment of these chronic conditions is sometimes hampered by patient non-adherence to polytherapy. The options available for polytherapy are either the sequential addition of individual drug products to deliver an effective multi-drug regimen or the use of a single fixed-dose combination (FDC) therapy product...
January 26, 2024: Pharmaceutics
https://read.qxmd.com/read/38398882/vitamin-d-status-vdr-and-tlr-polymorphisms-and-pulmonary-tuberculosis-epidemiology-in-kazakhstan
#31
JOURNAL ARTICLE
Dauren Yerezhepov, Aidana Gabdulkayum, Ainur Akhmetova, Ulan A Kozhamkulov, Saule E Rakhimova, Ulykbek Y Kairov, Gulnur Zhunussova, Ruslan N Kalendar, Ainur Akilzhanova
BACKGROUND: Tuberculosis (TB) and vitamin D deficiency remain major public health problems in Kazakhstan. Due to the high incidence of pulmonary tuberculosis in the country and based on the importance of vitamin D in the modulation of the immune response and the association of its deficiency with many health conditions, the aim of our research was to study the vitamin D status, VDR and TLR gene polymorphisms, and pulmonary tuberculosis epidemiology in Kazakhstan. METHODS: A case-control study included 411 individuals diagnosed with pulmonary TB and 686 controls with no family history of pulmonary tuberculosis...
February 17, 2024: Nutrients
https://read.qxmd.com/read/38395126/microfluidics-as-diagnostic-tools
#32
REVIEW
Avanthika Satish Kumar, Sneha Venkatesalu, Shanmugapriya Dilliyappan, Ajay Prakash Pasupulla, Lavanya Prathap, Thirunavukkarasu Palaniyandi, Gomathy Baskar, Maddaly Ravi, Abimanyu Sugumaran
The challenges in the management of human diseases are largely determined by the precision, speed and ease of diagnostic procedures available. Developments in biomedical engineering technologies have greatly helped in transforming human health care, especially for disease diagnosis which in turn lead to better patient outcomes. One such development is in the form of microfluidic chip technology which has transformed various aspects of human health care. We present in this review, a comprehensive account on the utility of microfluidic chip technologies for the diagnosis of autoimmune disorders, cardiovascular diseases (CVDs), infectious diseases, and neurodegenerative conditions...
February 21, 2024: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://read.qxmd.com/read/38393123/the-yield-of-active-tuberculosis-disease-and-latent-tuberculosis-infection-in-tuberculosis-household-contacts-investigated-using-chest-x-ray-in-yogyakarta-province-indonesia
#33
JOURNAL ARTICLE
Betty Nababan, Rina Triasih, Geoffrey Chan, Bintari Dwihardiani, Arif Hidayat, Setyogati C Dewi, Lana Unwanah, Arif Mustofa, Philipp du Cros
In Indonesia, the implementation of tuberculosis (TB) contact investigation is limited, with low detection rates. We report the yield of and risk factors for TB disease and infection for household contacts (HHCs) investigated using chest X-ray (CXR) screening. We identified HHCs aged five years and above of bacteriologically confirmed index cases from 2018 to 2022 in Yogyakarta City and Kulon Progo. All HHCs were offered screening for TB symptoms; TB infection testing with either tuberculin skin testing or interferon gamma release assay; and referral for CXR...
January 31, 2024: Tropical Medicine and Infectious Disease
https://read.qxmd.com/read/38390008/-drug-resistant-pulmonary-tuberculosis-at-maradi-regional-hospital-center-niger-2014-2018
#34
JOURNAL ARTICLE
Mahaman Laouali Harouna Amadou, Ibrahim Maman Lawan, Ousmane Abdoulaye, Abdoul Kadir Ibrahim Mamadou, Oumarou Amadou, Hassane Boureima, Biraima Ahamadou, Nouhou Hama Aghali, Nana Hadiza Abdourahamane Maifada, Abdoulaziz Kabirou Amoussa, Chaibou Maidakouale
AIM OF STUDY: To describe the clinical, therapeutic and evolutionary profile of patients followed for rifampicin-resistant pulmonary tuberculosis (RR-TB) at the Regional Hospital Centre (RHC) of Maradi (Niger) from 2014 to 2018. METHODS: We conducted a retrospective and descriptive study based on the records of patients followed for Multidrug-resistant tuberculosis (MDR-TB) between January 1, 2014 and June 30, 2018 at the resistant tuberculosis management unit in Maradi (Niger)...
December 31, 2023: Med Trop Sante Int
https://read.qxmd.com/read/38389045/tuberculosis-and-diabetes-mellitus-comorbidity-in-an-adult-ugandan-population
#35
JOURNAL ARTICLE
Davis Kibirige, Irene Andia-Biraro, Ronald Olum, Susan Adakun, Stella Zawedde-Muyanja, Christine Sekaggya-Wiltshire, Ivan Kimuli
BACKGROUND: Diabetes mellitus (DM) has a direct impact on the clinical manifestation and prognosis of active tuberculosis disease (TB) and is known to increase the chance of developing the condition. We sought to determine the prevalence of DM in adult Ugandan patients with recently diagnosed TB and the associated sociodemographic, anthropometric, and metabolic characteristics of TB-DM comorbidity. METHODS: In this cross-sectional study conducted at the adult TB treatment centres of three tertiary healthcare facilities in Uganda, we screened adult participants with recently diagnosed TB (diagnosed in < 2 months) for DM...
February 22, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38388163/a-model-based-approach-to-estimating-the-prevalence-of-disease-combinations-in-south-africa
#36
JOURNAL ARTICLE
Leigh F Johnson, Reshma Kassanjee, Naomi Folb, Sarah Bennett, Andrew Boulle, Naomi S Levitt, Robyn Curran, Kirsty Bobrow, Rifqah A Roomaney, Max O Bachmann, Lara R Fairall
BACKGROUND: The development of strategies to better detect and manage patients with multiple long-term conditions requires estimates of the most prevalent condition combinations. However, standard meta-analysis tools are not well suited to synthesising heterogeneous multimorbidity data. METHODS: We developed a statistical model to synthesise data on associations between diseases and nationally representative prevalence estimates and applied the model to South Africa...
February 22, 2024: BMJ Global Health
https://read.qxmd.com/read/38385377/spectrum-of-pneumonia-in-renal-transplant-recipients-an-indian-experience
#37
JOURNAL ARTICLE
Sukanya Govindan, Sahil Bagai, Raja Ramachandran, Vivek Kumar, Manish Rathi, Harbir S Kohli, Ashish Sharma, Krishan Lal Gupta
OBJECTIVES: Respiratory tract infections are life-threatening infections in solid-organ transplant recipients that pose risk to the graft and to the patient. This study was undertaken to examine the clinical and microbiological spectrum of pneumonia in renal transplant recipients. MATERIALS AND METHODS: Of 400 consecutive renal transplant recipients, 87 recipients (21.8%) were hospitalized between November 2014 and October 2016 with pneumonia. We examined demographic profiles and clinical investigations...
January 2024: Experimental and Clinical Transplantation
https://read.qxmd.com/read/38383057/framingham-risk-score-based-vascular-outcomes-in-acute-versus-chronic-hiv-cohorts-after-6%C3%A2-years-of-art
#38
JOURNAL ARTICLE
Kathryn Brown Holroyd, Win Min Han, Tanakorn Apornpong, Lydie Trautmann, Sivaporn Gatechompol, Akarin Hiransuthikul, Sasiwimol Ubolyam, Carlo Sacdalan, Somchai Sriplienchan, Ratchapong Kanaprach, Stephen Kerr, Anchalee Avihingsanon, Serena Spudich, Phillip Chan
INTRODUCTION: Immune dysregulation persists in people with HIV (PWH) on antiretroviral therapy (ART) and may lead to accelerated vascular ageing and cardiovascular disease (CVD). While delayed time to initiation of ART has been linked to worse cardiovascular outcomes, the effect of ART initiation during acute infection on these outcomes is not well understood. METHODS: Participants were enrolled from the SEARCH010/RV254 acute HIV (AHI) and HIV-NAT chronic HIV (CHI) cohorts in Thailand...
February 21, 2024: HIV Medicine
https://read.qxmd.com/read/38381724/hiv-multimorbidity-and-health-related-quality-of-life-in-rural-kwazulu-natal-south-africa-a-population-based-study
#39
JOURNAL ARTICLE
Amelia M Stanton, Ryan L Boyd, Conall O'Cleirigh, Stephen Olivier, Brett Dolotina, Resign Gunda, Olivier Koole, Dickman Gareta, Tshwaraganang H Modise, Zahra Reynolds, Thandeka Khoza, Kobus Herbst, Thumbi Ndung'u, Willem A Hanekom, Emily B Wong, Deenan Pillay, Mark J Siedner
Health-related quality of life (HRQoL) assesses the perceived impact of health status across life domains. Although research has explored the relationship between specific conditions, including HIV, and HRQoL in low-resource settings, less attention has been paid to the association between multimorbidity and HRQoL. In a secondary analysis of cross-sectional data from the Vukuzazi ("Wake up and know ourselves" in isiZulu) study, which identified the prevalence and overlap of non-communicable and infectious diseases in the uMkhanyakunde district of KwaZulu-Natal, we (1) evaluated the impact of multimorbidity on HRQoL; (2) determined the relative associations among infectious diseases, non-communicable diseases (NCDs), and HRQoL; and (3) examined the effects of controlled versus non-controlled disease on HRQoL...
2024: PloS One
https://read.qxmd.com/read/38380250/an-integrative-multi-omics-approach-to-characterize-interactions-between-tuberculosis-and-diabetes-mellitus
#40
JOURNAL ARTICLE
Caian L Vinhaes, Eduardo R Fukutani, Gabriel C Santana, María B Arriaga, Beatriz Barreto-Duarte, Mariana Araújo-Pereira, Mateus Maggiti-Bezerril, Alice M S Andrade, Marina C Figueiredo, Ginger L Milne, Valeria C Rolla, Afrânio L Kristki, Marcelo Cordeiro-Santos, Timothy R Sterling, Bruno B Andrade, Artur T L Queiroz
Tuberculosis-diabetes mellitus (TB-DM) is linked to a distinct inflammatory profile, which can be assessed using multi-omics analyses. Here, a machine learning algorithm was applied to multi-platform data, including cytokines and gene expression in peripheral blood and eicosanoids in urine, in a Brazilian multi-center TB cohort. There were four clinical groups: TB-DM(n = 24), TB only(n = 28), DM(HbA1c ≥ 6.5%) only(n = 11), and a control group of close TB contacts who did not have TB or DM(n = 13)...
March 15, 2024: IScience
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