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Tuberculosis diabetes

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https://www.readbyqxmd.com/read/28937523/cytomegalovirus-retinitis-associated-with-occlusive-vasculopathy-in-an-elderly-human-immunodeficiency-virus-negative-man
#1
Kareem Moussa, Thuy Doan, Jay M Stewart, Jessica Shantha, John Gonzales, Nisha Acharya, Emmett T Cunningham
PURPOSE: To present a case of cytomegalovirus (CMV) retinitis associated with occlusive vasculopathy presenting as sudden unilateral loss of vision in a human immunodeficiency virus-negative elderly man. METHODS: Clinical case report and literature review. RESULTS: An 84-year-old Chinese man with diabetes mellitus and primary open-angle glaucoma was seen in consultation by our uveitis service for evaluation of sudden vision loss in the right eye...
September 20, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28934668/diabetes-mellitus-increased-all-cause-mortality-rate-among-newly-diagnosed-tuberculosis-patients-in-an-asian-population-a-nationwide-population-based-study
#2
Po-Yen Ko, Shi-Dou Lin, Ming-Chia Hsieh, Yu-Cheng Chen
AIMS: To investigate the effect of diabetes mellitus (DM) on all-cause mortality among patients with newly-diagnosed tuberculosis (TB) in an Asian population. We also identified risk factors for mortality in these patients. METHODS: The data were obtained from the National Health Insurance Research Database and included 9831 newly-diagnosed TB individuals and 1627 TB mortality cases in the period of 2000-2010. The mortality data were divided into a DM group and a non-DM group...
September 1, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28919116/global-regional-and-national-age-sex-specific-mortality-for-264-causes-of-death-1980-2016-a-systematic-analysis-for-the-global-burden-of-disease-study-2016
#3
(no author information available yet)
BACKGROUND: Monitoring levels and trends in premature mortality is crucial to understanding how societies can address prominent sources of early death. The Global Burden of Disease 2016 Study (GBD 2016) provides a comprehensive assessment of cause-specific mortality for 264 causes in 195 locations from 1980 to 2016. This assessment includes evaluation of the expected epidemiological transition with changes in development and where local patterns deviate from these trends. METHODS: We estimated cause-specific deaths and years of life lost (YLLs) by age, sex, geography, and year...
September 16, 2017: Lancet
https://www.readbyqxmd.com/read/28910369/heightened-circulating-levels-of-antimicrobial-peptides-in-tuberculosis-diabetes-co-morbidity-and-reversal-upon-treatment
#4
Nathella Pavan Kumar, Kadar Moideen, Vijay Viswanathan, Shanmugam Sivakumar, Pradeep A Menon, Hardy Kornfeld, Subash Babu
BACKGROUND: The association of antimicrobial peptides (AMPs) with tuberculosis-diabetes comorbidity (PTB-DM) is not well understood. METHODS: To study the association of AMPs with PTB-DM, we examined the systemic levels of cathelicidin (LL37), human beta defensin- 2 (HBD2), human neutrophil peptides 1-3, (HNP1-3) and granulysin in individuals with either PTB-DM, PTB, latent TB (LTB) or no TB infection (NTB). RESULTS: Circulating levels of cathelicidin and HBD2 were significantly higher and granulysin levels were significantly lower in PTB-DM compared to PTB, LTB or NTB, while the levels of HNP1-3 were significantly higher in PTB-DM compared to LTB or NTB individuals...
2017: PloS One
https://www.readbyqxmd.com/read/28903800/predicting-treatment-failure-death-and-drug-resistance-using-a-computed-risk-score-among-newly-diagnosed-tb-patients-in-tamaulipas-mexico
#5
B E Abdelbary, M Garcia-Viveros, H Ramirez-Oropesa, M H Rahbar, B I Restrepo
The purpose of this study was to develop a method for identifying newly diagnosed tuberculosis (TB) patients at risk for TB adverse events in Tamaulipas, Mexico. Surveillance data between 2006 and 2013 (8431 subjects) was used to develop risk scores based on predictive modelling. The final models revealed that TB patients failing their treatment regimen were more likely to have at most a primary school education, multi-drug resistance (MDR)-TB, and few to moderate bacilli on acid-fast bacilli smear. TB patients who died were more likely to be older males with MDR-TB, HIV, malnutrition, and reporting excessive alcohol use...
September 14, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28902922/molecular-clustering-of-patients-with-diabetes-and-pulmonary-tuberculosis-a-systematic-review-and-meta-analysis
#6
Francles Blanco-Guillot, Guadalupe Delgado-Sánchez, Norma Mongua-Rodríguez, Pablo Cruz-Hervert, Leticia Ferreyra-Reyes, Elizabeth Ferreira-Guerrero, Mercedes Yanes-Lane, Rogelio Montero-Campos, Miriam Bobadilla-Del-Valle, Pedro Torres-González, Alfredo Ponce-de-León, José Sifuentes-Osornio, Lourdes Garcia-Garcia
INTRODUCTION: Many studies have explored the relationship between diabetes mellitus (DM) and tuberculosis (TB) demonstrating increased risk of TB among patients with DM and poor prognosis of patients suffering from the association of DM/TB. Owing to a paucity of studies addressing this question, it remains unclear whether patients with DM and TB are more likely than TB patients without DM to be grouped into molecular clusters defined according to the genotype of the infecting Mycobacterium tuberculosis bacillus...
2017: PloS One
https://www.readbyqxmd.com/read/28894532/an-ethno-pharmacological-study-of-plants-used-for-traditional-medication-in-tangail-district-bangladesh
#7
A H M Mahmudur Rahman, Mahmoud Rafieian-Kopaei
BACKGROUND: In Bangladesh, folk medicinal practitioners are called "Kaviraj" and are consulted for treatment of various ailments by a large part of the rural and urban population. There are some previous studies conducted in the Tangail district of Bangladesh about medicinal plants, but there is no relevant information about this aspect in some parts of this district. AIM: To conduct an ethno-pharmacological survey among the "Kaviraj" of two upazilas (regions) in Tangail district, namely Tangail Sadar Upazila and Nagarpur Upazila, to identify the trouble-free formulations of medicinal plants for various diseases used by the folk medicine practitioners on or after other forms of medical practices...
July 2017: Electronic Physician
https://www.readbyqxmd.com/read/28882103/low-serum-vitamin-d-levels-in-type-2-diabetes-patients-are-associated-with-decreased-mycobacterial-activity
#8
María Teresa Herrera, Yolanda Gonzalez, Fernando Hernández-Sánchez, Guadalupe Fabián-San Miguel, Martha Torres
BACKGROUND: Concurrent diabetes mellitus and tuberculosis represent a significant health problem worldwide. Patients with diabetes mellitus have a high risk of tuberculosis, which may be mediated by an abnormal innate immune response due to hyperglycaemia or low vitamin D levels. METHODS: In the present study, we evaluated inactive vitamin D serum levels and the monocyte response to infection with M. tuberculosis, including phagocytosis of M. tuberculosis, antimycobacterial activity, LL-37, human β defensin-2 and IL-10 gene expression and nitric oxide production, between type 2 diabetes mellitus patients (n = 51) and healthy volunteers (n = 38)...
September 7, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28869693/diabetes-prevalence-and-its-impact-on-health-related-quality-of-life-in-tuberculosis-patients
#9
Ali Nasir Siddiqui, Khalid Umer Khayyam, Nahida Siddiqui, Rohit Sarin, Manju Sharma
OBJECTIVE: To determine the prevalence of diabetes mellitus (DM), assess its influence on health-related quality of life (HRQoL) among TB patients. METHODS: In this prospective study, eligible patients at three primary health care centers in urban slum region of South Delhi, India, underwent blood glucose screening at treatment initiation. HRQoL scores were determined by conducting face-to-face interviews using Dhingra and Rajpal (DR-12) scale at pretreatment, end of intensive phase and end of the treatment...
September 4, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28862176/index-tb-guidelines-guidelines-on-extrapulmonary-tuberculosis-for-india
#10
Surendra K Sharma, H Ryan, Sunil Khaparde, K S Sachdeva, Achintya D Singh, Alladi Mohan, Rohit Sarin, C N Paramasivan, Prahlad Kumar, Neeraj Nischal, Saurav Khatiwada, Paul Garner, Prathap Tharyan
Extrapulmonary tuberculosis (EPTB) is frequently a diagnostic and therapeutic challenge. It is a common opportunistic infection in people living with HIV/AIDS and other immunocompromised states such as diabetes mellitus and malnutrition. There is a paucity of data from clinical trials in EPTB and most of the information regarding diagnosis and management is extrapolated from pulmonary TB. Further, there are no formal national or international guidelines on EPTB. To address these concerns, Indian EPTB guidelines were developed under the auspices of Central TB Division and Directorate of Health Services, Ministry of Health and Family Welfare, Government of India...
April 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28852602/the-importance-of-a-complete-differential-case-report-of-a-tuberculoma-in-a-patient-without-pulmonary-involvement
#11
Pooja Sethi, Jennifer Treece, Chidinma Onweni, Vandana Pai, Zia Rahman, Siddharth Singh
Patients with a tuberculoma typically present with pulmonary involvement of tuberculosis and have risk factors for tuberculosis (TB). The risk factors for tuberculosis include bacillary load, proximity to infectious case, immunosuppressive conditions, malnutrition, young age, diabetes mellitus, working in healthcare, recent incarceration, alcohol use, and tobacco use. Although rare, it is possible for a patient to present with a tuberculoma despite the absence of risk factors for tuberculosis other than diabetes and without pulmonary involvement...
June 28, 2017: Curēus
https://www.readbyqxmd.com/read/28852286/sputum-conversion-and-treatment-success-among-tuberculosis-patients-with-diabetes-treated-under-the-tuberculosis-control-programme-in-an-urban-setting-in-south-india
#12
Velayutham Banurekha, Tarun Bhatnagar, Swaminathan Savithri, Natarajan Dinesh Kumar, Boopathi Kangusamy, Sanjay Mehendale
BACKGROUND: Studies from India on sputum conversion and tuberculosis (TB) treatment outcomes among TB patients with diabetes are limited. OBJECTIVE: The objective of this study is to estimate the proportion of sputum smear conversion and successful treatment outcomes among diabetic-TB patients treated under Revised National TB Control Programme (RNTCP). METHODOLOGY: Information on TB disease, diabetes, sputum conversion, and treatment outcomes were collected from treatment cards of adult TB patients (age >18 years) treated in the District TB Centre TB Unit, Tiruchirapalli, Tamil Nadu from July 1, 2014, to October 31, 2015...
July 2017: Indian Journal of Community Medicine
https://www.readbyqxmd.com/read/28847048/-number-of-deaths-that-attributable-to-high-fasting-plasma-glucose-among-population-aged-25-and-above-and-its-impact-on-life-expectancy-in-china-2013
#13
Y F Zhao, Z Q Wang, J Yang, Y N Liu, S W Liu, X Y Zeng, Y C Li, P Yin, M G Zhou
Objective: To analyze deaths that attributable to high fasting plasma glucose and its impact on life expectancy among Chinese residents in 2013. Methods: Data from the Mortality Surveillance Programs in National Disease Surveillance Points System and the China Chronic Disease Surveillance (2013) were used. Death attributed to high fasting plasma glucose and its impact on the life expectancy of Chinese residents were estimated, based on the principle of population attributable fraction. Results: In 2013, the total number of deaths attributed to high fasting plasma glucose among aged ≥25 years old was 621 thousand, with 333 thousand males and 288 thousand females...
August 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28843039/tnf-tnf-inducers-and-tnfr2-agonists-a-new-path-to-type-1-diabetes-treatment
#14
REVIEW
Denise L Faustman
BACKGROUND: In the past decade, interest in the century-old tuberculosis vaccine, bacillus Calmette-Guerin (BCG), has been revived for potential new therapeutic uses in type 1 diabetes and other forms of autoimmunity. METHODS: Diverse clinical trials are now proving the value of BCG in prevention and treatment of type 1 diabetes, in the treatment of new onset multiple sclerosis and other immune conditions. BCG contains the avirulent tuberculosis strain Mycobacterium bovis, a vaccine originally developed for tuberculosis prevention...
August 26, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28840092/smear-grading-and-the-mantoux-skin-test-can-be-used-to-predict-sputum-smear-conversion-in-patients-suffering-from-tuberculosis
#15
Mahmood Saffari, Hadis Alizadeh Jolandimi, Mojtaba Sehat, Nastarn Vali Nejad, Mehrdad Hedayati, Mahbobeh Zamani, Amir Ghasemi
Purpose: Smear scores and induration sizes resulting from the PPD (tuberculin purified protein derivative) test can serve as indicators of whether a patient suffering from tuberculosis shows smear conversion or not. Methods: Using microbiological methods smear and sputum tests, patients diagnosed as infected with Mycobacterium tuberculosis between 2002 and 2015 were included in this study. All of the assumed factors that may have a role in smear conversion were studied, in addition to the prolongation of tuberculosis...
2017: GMS Hygiene and Infection Control
https://www.readbyqxmd.com/read/28826452/fast-implementation-in-bangladesh-high-frequency-of-unsuspected-tuberculosis-justifies-challenges-of-scale-up
#16
R R Nathavitharana, P Daru, A E Barrera, S M Mostofa Kamal, S Islam, M Ul-Alam, R Sultana, M Rahman, Md S Hossain, P Lederer, S Hurwitz, K Chakraborty, N Kak, D B Tierney, E Nardell
SETTING: National Institute of Diseases of the Chest and Hospital, Dhaka; Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders, Dhaka; and Chittagong Chest Disease Hospital, Chittagong, Bangladesh. OBJECTIVE: To present operational data and discuss the challenges of implementing FAST (Find cases Actively, Separate safely and Treat effectively) as a tuberculosis (TB) transmission control strategy. DESIGN: FAST was implemented sequentially at three hospitals...
September 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28820679/tuberculosis-related-diabetes-is-it-reversible-after-complete-treatment
#17
Huma Aftab, Dirk L Christensen, Atiqa Ambreen, Mohammad Jamil, Peter Garred, Jørgen H Petersen, Susanne D Nielsen, Ib C Bygbjerg
Individuals with newly diagnosed tuberculosis (TB) were screened for diabetes (DM) with fasting plasma glucose (FPG) in Pakistan. A significant decrease in FPG was observed when TB was treated. Of those with newly diagnosed DM, 46% and 62% no longer had hyperglycemia after 3 and 6 months, respectively. Individuals with known DM also showed a significant decrease in fasting plasma levels when treated for TB, but after 3 months none had normoglycemia, and after 6 months 9.2% were normoglycemic. Thus, TB-related DM may abate when the stress terminates, as is the case in gestational DM...
August 7, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28810840/the-association-between-tuberculosis-and-the-development-of-insulin-resistance-in-adults-with-pulmonary-tuberculosis-in-the-western-sub-district-of-the-cape-metropole-region-south-africa-a-combined-cross-sectional-cohort-study
#18
Lauren Philips, Janicke Visser, Daan Nel, Renée Blaauw
BACKGROUND: The existence of a bi-directional relationship between tuberculosis (TB) and insulin resistance (IR)/diabetes has been alluded to in literature. Although diabetes has been linked to increased tuberculosis risk, the relationship between tuberculosis as a causative factor for IR remains unclear. The study aimed to determine if an association existed between tuberculosis and IR development in adults with newly diagnosed pulmonary tuberculosis at baseline. It was additionally aimed to document changes in IR status during TB follow-up periods...
August 15, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28776527/knowledge-on-tuberculosis-among-the-members-of-a-rural-community-in-myanmar
#19
Kyaw San Lin, Chit Sandy Kyaw, Ye Pyae Sone, Su Yi Win
BACKGROUND: Myanmar, one of the high tuberculosis (TB) burden countries, is in serious need of research work to develop strategies aiming to tackle the problem. Conducting a study on the knowledge of the population will help understand the flaws in the National TB Control Program (NTP), and how to correct them, and further strategic planning to reach the goals of Sustainable Development Goals. AIMS: The aim of the study was to access sociodemographic characteristics, knowledge, and behavioral practice of TB among the community members in Ngar Syu Taung Village, Hlegu Township...
July 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28774694/improvement-of-fungal-disease-identification-and-management-combined-health-systems-and-public-health-approaches
#20
REVIEW
Donald C Cole, Nelesh P Govender, Arunaloke Chakrabarti, Jahit Sacarlal, David W Denning
More than 1·6 million people are estimated to die of fungal diseases each year, and about a billion people have cutaneous fungal infections. Fungal disease diagnosis requires a high level of clinical suspicion and specialised laboratory testing, in addition to culture, histopathology, and imaging expertise. Physicians with varied specialist training might see patients with fungal disease, yet it might remain unrecognised. Antifungal treatment is more complex than treatment for bacterial or most viral infections, and drug interactions are particularly problematic...
July 31, 2017: Lancet Infectious Diseases
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