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running and proBNP

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https://www.readbyqxmd.com/read/28685712/effects-of-traditional-chinese-medicine-shensong-yangxin-capsules-on-heart-rhythm-and-function-in-congestive-heart-failure-patients-with-frequent-ventricular-premature-complexes-a-randomized-double-blind-multicenter-clinical-trial
#1
Xi Wang, Dan Hu, Song Dang, He Huang, Cong-Xin Huang, Ming-Jie Yuan, Yan-Hong Tang, Qing-Shan Zheng, Fang Yin, Shu Zhang, Bo-Li Zhang, Run-Lin Gao
BACKGROUND: Pharmacological therapy for congestive heart failure (CHF) with ventricular arrhythmia is limited. In the study, our aim was to evaluate the effects of Chinese traditional medicine Shensong Yangxin capsules (SSYX) on heart rhythm and function in CHF patients with frequent ventricular premature complexes (VPCs). METHODS: This double-blind, placebo-controlled, multicenter study randomized 465 CHF patients with frequent VPCs to the SSYX (n = 232) and placebo groups (n = 233) for 12 weeks of treatment...
July 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28382580/the-dynamics-of-cardiovascular-biomarkers-in-non-elite-marathon-runners
#2
Emma Roca, Lexa Nescolarde, Josep Lupón, Jaume Barallat, James L Januzzi, Peter Liu, M Cruz Pastor, Antoni Bayes-Genis
The number of recreational/non-elite athletes participating in marathons is increasing, but data regarding impact of endurance exercise on cardiovascular health are conflicting. This study evaluated 79 recreational athletes of the 2016 Barcelona Marathon (72% men; mean age 39 ± 6 years; 71% ≥35 years). Blood samples were collected at baseline (24-48 h before the race), immediately after the race (1-2 h after the race), and 48-h post-race. Amino-terminal pro-B type natriuretic peptide (NT-proBNP, a marker of myocardial strain), ST2 (a marker of extracellular matrix remodeling and fibrosis, inflammation, and myocardial strain), and high-sensitivity troponin T (hs-TnT, a marker of myocyte stress/injury) were assayed...
April 5, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28356642/the-effects-of-preceding-exercise-on-myocardial-damage-in-rats
#3
Seung Hee Hyun, Young Mi Kim, Su Jin Park
[Purpose] The purpose of this study was to investigate the effects of exercise on myocardial injury in male Sprague-Dawley rats. Two groups of rats were trained with either moderate- or high-intensity treadmill running for four weeks. Subsequently, the concentrations of cardiac troponin and the N-terminal of prohormone brain natriuretic peptide (NT-proBNP) were examined following a single bout of prolonged intensive exercise (lasting 3 h). [Subjects and Methods] The study included 40 six-week-old male Sprague-Dawley rats weighing 150-180 g each...
March 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28353316/quality-of-care-of-hospitalised-patients-with-heart-failure-in-poland-in-2013-results-of-the-second-nationwide-survey
#4
Małgorzata Fedyk-Łukasik, Barbara Wizner, Grzegorz Opolski, Tomasz Zdrojewski, Marcin Czech, Jacek S Dubiel, Michał Marchel, Tomasz Rywik, Jerzy Korewicki, Tomasz Grodzicki
BACKGROUND: Optimal management of heart failure (HF) patients is crucial to reduce both mortality and the number of hospital admissions, at the same time improving patients' quality of life. AIM: The aim of the study was to assess the quality of care of hospitalised patients with HF in Poland in 2013 and compare it with the results of a similar survey performed in 2005. METHODS: The presented study was conducted from April to November 2013 in a sample of 260 hospital wards in Poland, recruited by stratified proportional sampling...
2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28177719/impact-of-polyphenols-on-physiological-stress-and-cardiac-burden-in-marathon-runners-results-from-a-substudy-of-the-bemagic-study
#5
Sebastian Clauss, Johannes Scherr, Alan Hanley, Jens Schneider, Ina Klier, Korbinian Lackermair, Eva Hoster, Michael Vogeser, David C Nieman, Martin Halle, Thomas Nickel
Both physiologic stress and chronic heart disease are associated with increased systemic levels of chromogranin A (CGA) and NT-proBNP. Marathon running causes physiological stress and imposes a significant cardiac burden. Polyphenol-rich Mediterranean and Asian diets have been demonstrated to exert beneficial effects on the cardiovascular system. In this study we investigated whether pretreatment with a polyphenol beverage could attenuate the physiological and cardiac stress associated with a marathon. In the BeMaGIC trial, 277 athletes were randomized into 2 groups in a double-blinded fashion, receiving 1-1...
May 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28024961/efficacy-and-safety-of-sacubitril-valsartan-lcz696-in-japanese-patients-with-chronic-heart-failure-and-reduced-ejection-fraction-rationale-for-and-design-of-the-randomized-double-blind-parallel-hf-study
#6
Hiroyuki Tsutsui, Shinichi Momomura, Yoshihiko Saito, Hiroshi Ito, Kazuhiro Yamamoto, Tomomi Ohishi, Naoko Okino, Weinong Guo
BACKGROUND: The prognosis of heart failure patients with reduced ejection fraction (HFrEF) in Japan remains poor, although there is growing evidence for increasing use of evidence-based pharmacotherapies in Japanese real-world HF registries. Sacubitril/valsartan (LCZ696) is a first-in-class angiotensin receptor neprilysin inhibitor shown to reduce mortality and morbidity in the recently completed largest outcome trial in patients with HFrEF (PARADIGM-HF trial). The prospectively designed phase III PARALLEL-HF (Prospective comparison of ARNI with ACE inhibitor to determine the noveL beneficiaL trEatment vaLue in Japanese Heart Failure patients) study aims to assess the clinical efficacy and safety of LCZ696 in Japanese HFrEF patients, and show similar improvements in clinical outcomes as the PARADIGM-HF study enabling the registration of LCZ696 in Japan...
December 23, 2016: Journal of Cardiology
https://www.readbyqxmd.com/read/26990595/pharmacodynamic-and-pharmacokinetic-profiles-of-sacubitril-valsartan-lcz696-in-patients-with-heart-failure-and-reduced-ejection-fraction
#7
Zhanna Kobalava, Yulia Kotovskaya, Oleg Averkov, Elena Pavlikova, Valentine Moiseev, Diego Albrecht, Priya Chandra, Surya Ayalasomayajula, Margaret F Prescott, Parasar Pal, Thomas H Langenickel, Pierre Jordaan, Iris Rajman
AIMS: Concomitant renin-angiotensin-aldosterone system blockade and natriuretic peptide system enhancement may provide unique therapeutic benefits to patients with heart failure and reduced ejection fraction (HFrEF). This study assessed the pharmacodynamics and pharmacokinetics of LCZ696 in patients with HFrEF. METHODS: This was an open-label, noncontrolled single-sequence study. After a 24-h run-in period, patients (n = 30) with HFrEF (EF ≤ 40%; NYHA class II-IV) received LCZ696 100 mg twice daily (bid) for 7 days and 200 mg bid for 14 days, along with standard treatment for heart failure (HF) (except angiotensin-converting enzyme inhibitors [ACEIs] or angiotensin receptor blockers [ARBs])...
August 2016: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/26853451/changes-in-the-markers-of-cardiac-damage-in-men-following-long-distance-and-ultra-long-distance-running-races
#8
Jin H Yoon, Yongbum Park, Jaeki Ahn, Kyung A Shin, Young J Kim
BACKGROUND: The aim of this study was to compare pre- and postcompetition markers of cardiac damage in ultraendurance athletes. METHODS: All the subjects had blood samples collected before starting and immediately after completing the running race, in order to analyze CK, hs-CRP, cTnI, and NT-proBNP. RESULTS: Before starting the marathon, there were no differences between the groups for all of the tests. CK was significantly higher after the 308 km ultra-marathon than after the marathon and the 100 km ultra-marathon (P<0...
March 2016: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/26688921/-first-experience-of-clinical-application-of-lcz696-an-at1-angiotensin-receptors-and-neprilysin-inhibitor-in-patients-with-chronic-heart-failure-and-reduced-ejection-fraction
#9
Zh D Kobalava, E P Pavlikova, O A Averkov, I Merai, L A Babaeva, I M Amirbegishvili, Yu V Kotovskaya, V S Moisfev
UNLABELLED: Simultaneous inhibition of the renin-angiotensin-aldosterone system and the system of degradation of natriuretic peptides can potentially provide unique therapeutic effects in patients with chronic heart failure (CHF) with reduced ejection fraction (EF). Aim of this study was to assess tolerability of therapy with LCZ696--first representative of a class of inhibitors of angiotensin receptor and neutral endopeptidase neprilysin--and to study its pharmacodynamic effects. METHODS: We included into open uncontrolled study 30 patients with stable functional class II-III CHF and EF ≤ 40%...
2015: Kardiologiia
https://www.readbyqxmd.com/read/26567808/bnp-and-nt-probnp-elevation-after-running-a-systematic-review
#10
REVIEW
Eduardo M Vilela, Rita Bettencourt-Silva, José P L Nunes, Vasco G Ribeiro
OBJECTIVE: A systematic review was carried out to study the pattern of BNP and NT-proBNP release after running. METHODS: Data were collected by searching the PubMed, ISI Web of Knowledge and Scopus databases. RESULTS: Fifty-three reports were identified as meeting the pre-specified criteria. Twenty-seven reports, representing 1,034 participants, presented data comparing post-running BNP or NT-proBNP levels with a pre-specified cut-off. Values exceeding the upper reference limit were seen in 22...
October 2015: Acta Cardiologica
https://www.readbyqxmd.com/read/26324638/detection-by-elisa-of-c-terminal-probnp-in-plasma-from-cats-with-cardiomyopathy
#11
Philip F Solter, Mark A Oyama, Maggie C Machen, Dennis J Trafny, D David Sisson
The B-type natriuretic peptide prohormone (proBNP) is enzymatically cleaved into an inactive N-terminal peptide and a biologically active C-terminal peptide with many beneficial cardiorenal effects. The purpose of this study was to develop and test in cats with cardiomyopathy an immunoassay to quantify the concentrations of C-terminal proBNP in feline plasma. An anti-canine proBNP monoclonal antibody (UI-1021) was shown to have adequate binding affinity to proBNP 80-106 for use in a solid-phase immunoassay, and by epitope mapping to bind within positions 84-87 of feline proBNP...
November 2015: Veterinary Journal
https://www.readbyqxmd.com/read/26073606/correlation-of-cardiac-markers-and-biomarkers-with-blood-pressure-of-middle-aged-marathon-runners
#12
Young-Joo Kim, Jae Ki Ahn, Kyung-A Shin, Chul-Hyun Kim, Yoon-Hee Lee, Kyoung-Min Park
Runners with exercise-induced high blood pressure have recently been reported to exhibit higher levels of cardiac markers, vasoconstrictors, and inflammation. The authors attempted to identify correlations between exercise-related personal characteristics and the levels of biochemical/cardiac markers in marathon runners in this study. Forty healthy runners were enrolled. Blood samples were taken both before and after finishing a full marathon. The change in each cardiac/biochemical marker over the course of the marathon was determined...
November 2015: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/25889047/cardiac-and-renal-function-in-a-large-cohort-of-amateur-marathon-runners
#13
Bernd Hewing, Sebastian Schattke, Sebastian Spethmann, Wasiem Sanad, Sabrina Schroeckh, Ingolf Schimke, Fabian Halleck, Harm Peters, Lars Brechtel, Jürgen Lock, Gert Baumann, Henryk Dreger, Adrian C Borges, Fabian Knebel
BACKGROUND: Participation of amateur runners in endurance races continues to increase. Previous studies of marathon runners have raised concerns about exercise-induced myocardial and renal dysfunction and damage. In our pooled analysis, we aimed to characterize changes of cardiac and renal function after marathon running in a large cohort of mostly elderly amateur marathon runners. METHODS: A total of 167 participants of the Berlin-Marathon (female n = 89, male n = 78; age = 50...
March 21, 2015: Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/25793960/quality-of-life-safety-and-efficacy-profile-of-thermostable-flolan-in-pulmonary-arterial-hypertension
#14
MULTICENTER STUDY
Steeve Provencher, Patrap Paruchuru, Andrea Spezzi, Brian Waterhouse, Mardi Gomberg-Maitland
BACKGROUND: Flolan (epoprostenol sodium) is most commonly prescribed to patients with severe pulmonary arterial hypertension (PAH) owing to the requirement that the drug be delivered by continuous intravenous infusion and the reconstituted solution may only be administered up to 24 hours when it is maintained between a temperature of 2°C and 8°C. The aim of this single-arm, open label study was to describe the effects of the new thermostable formulation of Flolan on health-related quality of life (HRQoL) and ease of administration in subjects switching from the currently marketed Flolan to the reformulated product...
2015: PloS One
https://www.readbyqxmd.com/read/25531109/prediction-of-cardiovascular-events-in-statin-treated-stable-coronary-patients-of-the-treating-to-new-targets-randomized-controlled-trial-by-lipid-and-non-lipid-biomarkers
#15
RANDOMIZED CONTROLLED TRIAL
Benoit J Arsenault, Philip Barter, David A DeMicco, Weihang Bao, Gregory M Preston, John C LaRosa, Scott M Grundy, Prakash Deedwania, Heiner Greten, Nanette K Wenger, James Shepherd, David D Waters, John J P Kastelein
UNLABELLED: Several plasma non-lipid biomarkers have been shown to predict major cardiovascular events (MCVEs) in population studies. Our objective was to investigate the relationship between lipid and non-lipid biomarkers levels achieved during statin therapy and the incidence of MCVEs in patients with stable coronary heart disease (CHD). We conducted a substudy of the TNT (Treating to New Targets) study, which was a randomized trial that compared the efficacy of high (80 mg) versus low (10 mg) dose atorvastatin for the secondary prevention of CHD...
2014: PloS One
https://www.readbyqxmd.com/read/25508788/early-start-exercise-training-after-acute-hemodynamic-decompensation-in-patients-with-chronic-heart-failure-re-start-a-multicenter-randomized-controlled-trial-on-short-term-feasibility-and-impact-on-functional-capacity-symptoms-and-neurohumoral-activation
#16
Alessandro Mezzani, Francesco Cacciatore, Raffaella Catanzaro, Alessandra Gualco, Daniela Guzzetti, Dario Leosco, Mauro Monelli, Franco Tarro Genta, Paolo Totaro, Egidio Traversi, Emanuela Zanelli, Pantaleo Giannuzzi
RE-START is a multicenter, randomized, prospective, open, controlled trial aiming to evaluate the feasibility and the short- and medium-term effects of an early-start AET program on functional capacity, symptoms and neurohormonal activation in chronic heart failure (CHF) patients with recent acute hemodynamic decompensation. Study endpoints will be: 1) safety of and compliance to AET; 2) effects of AET on i) functional capacity, ii) patient-reported symptoms and iii) AET-induced changes in beta-adrenergic receptor signaling and circulating angiogenetic and inflammatory markers...
March 2014: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/25481936/early-start-exercise-training-after-acute-hemodynamic-decompensation-in-patients-with-chronic-heart-failure-re-start-a-multicenter-randomized-controlled-trial-on-short-term-feasibility-and-impact-on-functional-capacity-symptoms-and-neurohumoral-activation
#17
RANDOMIZED CONTROLLED TRIAL
Alessandro Mezzani, Francesco Cacciatore, Raffaella Catanzaro, Alessandra Gualco, Daniela Guzzetti, Dario Leosco, Mauro Monelli, Franco Tarro Genta, Paolo Totaro, Egidio Traversi, Emanuela Zanelli, Pantaleo Giannuzzi
RE-START is a multicenter, randomized, prospective, open, controlled trial aiming to evaluate the feasibility and the short- and medium-term effects of an early-start AET program on functional capacity, symptoms and neurohormonal activation in chronic heart failure (CHF) patients with recent acute hemodynamic decompensation. Study endpoints will be: 1) safety of and compliance to AET; 2) effects of AET on i) functional capacity, ii) patient-reported symptoms and iii) AET-induced changes in beta-adrenergic receptor signaling and circulating angiogenetic and inflammatory markers...
March 2014: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/25476095/ventricular-myocardial-deformation-in-adults-after-early-surgical-repair-of-atrial-septal-defect
#18
Myrthe E Menting, Annemien E van den Bosch, Jackie S McGhie, Judith A A E Cuypers, Maarten Witsenburg, Marcel L Geleijnse, Willem A Helbing, Jolien W Roos-Hesselink
AIMS: It is unknown whether right-ventricular (RV) volume overload caused by an atrial septal defect (ASD) still has its effect on RV deformation long after repair. We evaluated RV and left-ventricular (LV) deformation beyond 30 years after surgical ASD repair in childhood, and studied relationships with conventional diagnostic parameters. METHODS AND RESULTS: In this prospective study, we included 102 subjects: 51 patients with repaired ASD (39% male, age 43.3 ± 4...
May 2015: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/24454874/development-of-a-novel-heart-failure-risk-tool-the-barcelona-bio-heart-failure-risk-calculator-bcn-bio-hf-calculator
#19
Josep Lupón, Marta de Antonio, Joan Vila, Judith Peñafiel, Amparo Galán, Elisabet Zamora, Agustín Urrutia, Antoni Bayes-Genis
BACKGROUND: A combination of clinical and routine laboratory data with biomarkers reflecting different pathophysiological pathways may help to refine risk stratification in heart failure (HF). A novel calculator (BCN Bio-HF calculator) incorporating N-terminal pro B-type natriuretic peptide (NT-proBNP, a marker of myocardial stretch), high-sensitivity cardiac troponin T (hs-cTnT, a marker of myocyte injury), and high-sensitivity soluble ST2 (ST2), (reflective of myocardial fibrosis and remodeling) was developed...
2014: PloS One
https://www.readbyqxmd.com/read/24444250/the-effects-of-running-a-308-km-ultra-marathon-on-cardiac-markers
#20
Young-Joo Kim, Young-Oh Shin, Jeong-Beom Lee, Yoon-Hee Lee, Kyung-A Shin, Al-Chan Kim, Choong-Won Goh, Chul Kim, Jae-Keun Oh, Young-Ki Min, Hun-Mo Yang
The aim of this study was to investigate the expression of cardiac strain and damage in 18 male marathoners with average age of 52.8 ± 5.0 years running at a 308 km ultra-marathon. Blood samples were collected at pre-race, 100 km, 200 km and 308 km check points for the analysis of cardiac muscle injury markers, creatine kinase (CK), creatine kinase-myocardial band (CK-MB), cardiac troponin I (cTnI) and cardiac muscle strain marker, N-terminal pro-brain natriuretic peptide (NT-proBNP). The CK levels increased 1127...
2014: European Journal of Sport Science
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