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running and proBNP

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https://www.readbyqxmd.com/read/26990595/pharmacodynamic-and-pharmacokinetic-profiles-of-sacubitril-valsartan-lcz696-in-patients-with-heart-failure-and-reduced-ejection-fraction
#1
Zhanna Kobalava, Yulia Kotovskaya, Oleg Averkov, Elena Pavlikova, Valentine Moiseev, Diego Albrecht, Priya Chandra, Surya Ayalasomayajula, Margaret F Prescott, Parasar Pal, Thomas H Langenickel, Pierre Jordaan, Iris Rajman
AIMS: Concomitant renin-angiotensin-aldosterone system blockade and natriuretic peptide system enhancement may provide unique therapeutic benefits to patients with heart failure and reduced ejection fraction (HFrEF). This study assessed the pharmacodynamics and pharmacokinetics of LCZ696 in patients with HFrEF. METHODS: This was an open-label, noncontrolled single-sequence study. After a 24-h run-in period, patients (n = 30) with HFrEF (EF ≤ 40%; NYHA class II-IV) received LCZ696 100 mg twice daily (bid) for 7 days and 200 mg bid for 14 days, along with standard treatment for heart failure (HF) (except angiotensin-converting enzyme inhibitors [ACEIs] or angiotensin receptor blockers [ARBs])...
August 2016: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/26853451/changes-in-the-markers-of-cardiac-damage-in-men-following-long-distance-and-ultra-long-distance-running-races
#2
Jin H Yoon, Yongbum Park, Jaeki Ahn, Kyung A Shin, Young J Kim
BACKGROUND: The aim of this study was to compare pre- and postcompetition markers of cardiac damage in ultraendurance athletes. METHODS: All the subjects had blood samples collected before starting and immediately after completing the running race, in order to analyze CK, hs-CRP, cTnI, and NT-proBNP. RESULTS: Before starting the marathon, there were no differences between the groups for all of the tests. CK was significantly higher after the 308 km ultra-marathon than after the marathon and the 100 km ultra-marathon (P<0...
March 2016: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/26688921/-first-experience-of-clinical-application-of-lcz696-an-at1-angiotensin-receptors-and-neprilysin-inhibitor-in-patients-with-chronic-heart-failure-and-reduced-ejection-fraction
#3
Zh D Kobalava, E P Pavlikova, O A Averkov, I Merai, L A Babaeva, I M Amirbegishvili, Yu V Kotovskaya, V S Moisfev
UNLABELLED: Simultaneous inhibition of the renin-angiotensin-aldosterone system and the system of degradation of natriuretic peptides can potentially provide unique therapeutic effects in patients with chronic heart failure (CHF) with reduced ejection fraction (EF). Aim of this study was to assess tolerability of therapy with LCZ696--first representative of a class of inhibitors of angiotensin receptor and neutral endopeptidase neprilysin--and to study its pharmacodynamic effects. METHODS: We included into open uncontrolled study 30 patients with stable functional class II-III CHF and EF ≤ 40%...
2015: Kardiologiia
https://www.readbyqxmd.com/read/26567808/bnp-and-nt-probnp-elevation-after-running-a-systematic-review
#4
REVIEW
Eduardo M Vilela, Rita Bettencourt-Silva, José P L Nunes, Vasco G Ribeiro
OBJECTIVE: A systematic review was carried out to study the pattern of BNP and NT-proBNP release after running. METHODS: Data were collected by searching the PubMed, ISI Web of Knowledge and Scopus databases. RESULTS: Fifty-three reports were identified as meeting the pre-specified criteria. Twenty-seven reports, representing 1,034 participants, presented data comparing post-running BNP or NT-proBNP levels with a pre-specified cut-off. Values exceeding the upper reference limit were seen in 22...
October 2015: Acta Cardiologica
https://www.readbyqxmd.com/read/26324638/detection-by-elisa-of-c-terminal-probnp-in-plasma-from-cats-with-cardiomyopathy
#5
Philip F Solter, Mark A Oyama, Maggie C Machen, Dennis J Trafny, D David Sisson
The B-type natriuretic peptide prohormone (proBNP) is enzymatically cleaved into an inactive N-terminal peptide and a biologically active C-terminal peptide with many beneficial cardiorenal effects. The purpose of this study was to develop and test in cats with cardiomyopathy an immunoassay to quantify the concentrations of C-terminal proBNP in feline plasma. An anti-canine proBNP monoclonal antibody (UI-1021) was shown to have adequate binding affinity to proBNP 80-106 for use in a solid-phase immunoassay, and by epitope mapping to bind within positions 84-87 of feline proBNP...
November 2015: Veterinary Journal
https://www.readbyqxmd.com/read/26073606/correlation-of-cardiac-markers-and-biomarkers-with-blood-pressure-of-middle-aged-marathon-runners
#6
Young-Joo Kim, Jae Ki Ahn, Kyung-A Shin, Chul-Hyun Kim, Yoon-Hee Lee, Kyoung-Min Park
Runners with exercise-induced high blood pressure have recently been reported to exhibit higher levels of cardiac markers, vasoconstrictors, and inflammation. The authors attempted to identify correlations between exercise-related personal characteristics and the levels of biochemical/cardiac markers in marathon runners in this study. Forty healthy runners were enrolled. Blood samples were taken both before and after finishing a full marathon. The change in each cardiac/biochemical marker over the course of the marathon was determined...
November 2015: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/25889047/cardiac-and-renal-function-in-a-large-cohort-of-amateur-marathon-runners
#7
Bernd Hewing, Sebastian Schattke, Sebastian Spethmann, Wasiem Sanad, Sabrina Schroeckh, Ingolf Schimke, Fabian Halleck, Harm Peters, Lars Brechtel, Jürgen Lock, Gert Baumann, Henryk Dreger, Adrian C Borges, Fabian Knebel
BACKGROUND: Participation of amateur runners in endurance races continues to increase. Previous studies of marathon runners have raised concerns about exercise-induced myocardial and renal dysfunction and damage. In our pooled analysis, we aimed to characterize changes of cardiac and renal function after marathon running in a large cohort of mostly elderly amateur marathon runners. METHODS: A total of 167 participants of the Berlin-Marathon (female n = 89, male n = 78; age = 50...
March 21, 2015: Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/25793960/quality-of-life-safety-and-efficacy-profile-of-thermostable-flolan-in-pulmonary-arterial-hypertension
#8
MULTICENTER STUDY
Steeve Provencher, Patrap Paruchuru, Andrea Spezzi, Brian Waterhouse, Mardi Gomberg-Maitland
BACKGROUND: Flolan (epoprostenol sodium) is most commonly prescribed to patients with severe pulmonary arterial hypertension (PAH) owing to the requirement that the drug be delivered by continuous intravenous infusion and the reconstituted solution may only be administered up to 24 hours when it is maintained between a temperature of 2°C and 8°C. The aim of this single-arm, open label study was to describe the effects of the new thermostable formulation of Flolan on health-related quality of life (HRQoL) and ease of administration in subjects switching from the currently marketed Flolan to the reformulated product...
2015: PloS One
https://www.readbyqxmd.com/read/25531109/prediction-of-cardiovascular-events-in-statin-treated-stable-coronary-patients-of-the-treating-to-new-targets-randomized-controlled-trial-by-lipid-and-non-lipid-biomarkers
#9
RANDOMIZED CONTROLLED TRIAL
Benoit J Arsenault, Philip Barter, David A DeMicco, Weihang Bao, Gregory M Preston, John C LaRosa, Scott M Grundy, Prakash Deedwania, Heiner Greten, Nanette K Wenger, James Shepherd, David D Waters, John J P Kastelein
UNLABELLED: Several plasma non-lipid biomarkers have been shown to predict major cardiovascular events (MCVEs) in population studies. Our objective was to investigate the relationship between lipid and non-lipid biomarkers levels achieved during statin therapy and the incidence of MCVEs in patients with stable coronary heart disease (CHD). We conducted a substudy of the TNT (Treating to New Targets) study, which was a randomized trial that compared the efficacy of high (80 mg) versus low (10 mg) dose atorvastatin for the secondary prevention of CHD...
2014: PloS One
https://www.readbyqxmd.com/read/25508788/early-start-exercise-training-after-acute-hemodynamic-decompensation-in-patients-with-chronic-heart-failure-re-start-a-multicenter-randomized-controlled-trial-on-short-term-feasibility-and-impact-on-functional-capacity-symptoms-and-neurohumoral-activation
#10
Alessandro Mezzani, Francesco Cacciatore, Raffaella Catanzaro, Alessandra Gualco, Daniela Guzzetti, Dario Leosco, Mauro Monelli, Franco Tarro Genta, Paolo Totaro, Egidio Traversi, Emanuela Zanelli, Pantaleo Giannuzzi
RE-START is a multicenter, randomized, prospective, open, controlled trial aiming to evaluate the feasibility and the short- and medium-term effects of an early-start AET program on functional capacity, symptoms and neurohormonal activation in chronic heart failure (CHF) patients with recent acute hemodynamic decompensation. Study endpoints will be: 1) safety of and compliance to AET; 2) effects of AET on i) functional capacity, ii) patient-reported symptoms and iii) AET-induced changes in beta-adrenergic receptor signaling and circulating angiogenetic and inflammatory markers...
March 2014: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/25481936/early-start-exercise-training-after-acute-hemodynamic-decompensation-in-patients-with-chronic-heart-failure-re-start-a-multicenter-randomized-controlled-trial-on-short-term-feasibility-and-impact-on-functional-capacity-symptoms-and-neurohumoral-activation
#11
RANDOMIZED CONTROLLED TRIAL
Alessandro Mezzani, Francesco Cacciatore, Raffaella Catanzaro, Alessandra Gualco, Daniela Guzzetti, Dario Leosco, Mauro Monelli, Franco Tarro Genta, Paolo Totaro, Egidio Traversi, Emanuela Zanelli, Pantaleo Giannuzzi
RE-START is a multicenter, randomized, prospective, open, controlled trial aiming to evaluate the feasibility and the short- and medium-term effects of an early-start AET program on functional capacity, symptoms and neurohormonal activation in chronic heart failure (CHF) patients with recent acute hemodynamic decompensation. Study endpoints will be: 1) safety of and compliance to AET; 2) effects of AET on i) functional capacity, ii) patient-reported symptoms and iii) AET-induced changes in beta-adrenergic receptor signaling and circulating angiogenetic and inflammatory markers...
March 2014: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/25476095/ventricular-myocardial-deformation-in-adults-after-early-surgical-repair-of-atrial-septal-defect
#12
Myrthe E Menting, Annemien E van den Bosch, Jackie S McGhie, Judith A A E Cuypers, Maarten Witsenburg, Marcel L Geleijnse, Willem A Helbing, Jolien W Roos-Hesselink
AIMS: It is unknown whether right-ventricular (RV) volume overload caused by an atrial septal defect (ASD) still has its effect on RV deformation long after repair. We evaluated RV and left-ventricular (LV) deformation beyond 30 years after surgical ASD repair in childhood, and studied relationships with conventional diagnostic parameters. METHODS AND RESULTS: In this prospective study, we included 102 subjects: 51 patients with repaired ASD (39% male, age 43.3 ± 4...
May 2015: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/24454874/development-of-a-novel-heart-failure-risk-tool-the-barcelona-bio-heart-failure-risk-calculator-bcn-bio-hf-calculator
#13
Josep Lupón, Marta de Antonio, Joan Vila, Judith Peñafiel, Amparo Galán, Elisabet Zamora, Agustín Urrutia, Antoni Bayes-Genis
BACKGROUND: A combination of clinical and routine laboratory data with biomarkers reflecting different pathophysiological pathways may help to refine risk stratification in heart failure (HF). A novel calculator (BCN Bio-HF calculator) incorporating N-terminal pro B-type natriuretic peptide (NT-proBNP, a marker of myocardial stretch), high-sensitivity cardiac troponin T (hs-cTnT, a marker of myocyte injury), and high-sensitivity soluble ST2 (ST2), (reflective of myocardial fibrosis and remodeling) was developed...
2014: PloS One
https://www.readbyqxmd.com/read/24444250/the-effects-of-running-a-308-km-ultra-marathon-on-cardiac-markers
#14
Young-Joo Kim, Young-Oh Shin, Jeong-Beom Lee, Yoon-Hee Lee, Kyung-A Shin, Al-Chan Kim, Choong-Won Goh, Chul Kim, Jae-Keun Oh, Young-Ki Min, Hun-Mo Yang
The aim of this study was to investigate the expression of cardiac strain and damage in 18 male marathoners with average age of 52.8 ± 5.0 years running at a 308 km ultra-marathon. Blood samples were collected at pre-race, 100 km, 200 km and 308 km check points for the analysis of cardiac muscle injury markers, creatine kinase (CK), creatine kinase-myocardial band (CK-MB), cardiac troponin I (cTnI) and cardiac muscle strain marker, N-terminal pro-brain natriuretic peptide (NT-proBNP). The CK levels increased 1127...
2014: European Journal of Sport Science
https://www.readbyqxmd.com/read/24088611/the-concentration-of-high-sensitivity-troponin-i-galectin-3-and-nt-probnp-substantially-increase-after-a-60-km-ultramarathon
#15
Gian Luca Salvagno, Federico Schena, Matteo Gelati, Elisa Danese, Gianfranco Cervellin, Gian Cesare Guidi, Giuseppe Lippi
BACKGROUND: The leading mechanisms responsible for the most prevalent and serious cardiac injuries include myocardiocyte stretch, myocardiocyte necrosis and cardiac fibrosis, which can now be reliably mirrored by measurement of natriuretic peptides, cardiospecific troponins and galectin-3, respectively. Although a large amount of knowledge has been gathered about the behavior and clinical significance of these biomarkers in patients with cardiac disorders, less information is available on their biology in paraphysiological conditions, including high-intensity endurance exercise...
February 2014: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/23929789/early-nt-probnp-decrease-with-ivabradine-in-ambulatory-patients-with-systolic-heart-failure
#16
Luis Sargento, Milan Satendra, Susana Longo, Nuno Lousada, Roberto Palma dos Reis
BACKGROUND: Heart rate (HR) reduction in patients with systolic heart failure (HF) is a cornerstone of current therapy. The aim of this study was to evaluate the short-term effect of the HR reduction with ivabradine on N-terminal pro-brain natriuretic peptide (NT-proBNP) in outpatients with systolic HF. HYPOTHESIS: Ivabradine improves survival and promotes left ventricle remodelling by reducing resting heart rate. Nt-ProBNP absolute and trends predict prognosis...
November 2013: Clinical Cardiology
https://www.readbyqxmd.com/read/23563576/dual-angiotensin-receptor-and-neprilysin-inhibition-as-an-alternative-to-angiotensin-converting-enzyme-inhibition-in-patients-with-chronic-systolic-heart-failure-rationale-for-and-design-of-the-prospective-comparison-of-arni-with-acei-to-determine-impact-on
#17
RANDOMIZED CONTROLLED TRIAL
John J V McMurray, Milton Packer, Akshay S Desai, Jim Gong, Martin P Lefkowitz, Adel R Rizkala, Jean Rouleau, Victor C Shi, Scott D Solomon, Karl Swedberg, Michael R Zile
AIMS: Although the focus of therapeutic intervention has been on neurohormonal pathways thought to be harmful in heart failure (HF), such as the renin-angiotensin-aldosterone system (RAAS), potentially beneficial counter-regulatory systems are also active in HF. These promote vasodilatation and natriuresis, inhibit abnormal growth, suppress the RAAS and sympathetic nervous system, and augment parasympathetic activity. The best understood of these mediators are the natriuretic peptides which are metabolized by the enzyme neprilysin...
September 2013: European Journal of Heart Failure
https://www.readbyqxmd.com/read/23444087/effects-of-marathon-running-on-cardiac-markers-and-endothelin-1-in-eih-athletes
#18
Y J Kim, Y O Shin, Y H Lee, H M Jee, K A Shin, C W Goh, C H Kim, Y K Min, H M Yang, J B Lee
The aim of the present study was to determine the changes in cardiac makers and endothelin-1 (ET-1) in marathoners with exercise induced hypertension compared to normotensive controls before and after running a marathon. Among a total of 70 volunteers, 10 marathoners with systolic blood pressure (SBP) greater than 210 mmHg during a treadmill exercise stress test were selected as an exercise-induced hypertension group (EIH) and 10 marathoners with normal SBP were selected as a control group (CON). Blood was collected from all volunteers 2 h before and immediately after a marathon: creatinine kinase (CK), CK-MB, cardiac tropoin-I (cTnI), N-terminal pro-brain natriuretic peptide (NT-proBNP), and endothelin-1(ET-1)...
September 2013: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/23365636/direct-immunochemiluminescent-assay-for-probnp-and-total-bnp-in-human-plasma-probnp-and-total-bnp-levels-in-normal-and-heart-failure
#19
Toshio Nishikimi, Hiroyuki Okamoto, Masahiro Nakamura, Naoko Ogawa, Kazukiyo Horii, Kiyoshi Nagata, Yasuaki Nakagawa, Hideyuki Kinoshita, Chinatsu Yamada, Kazuhiro Nakao, Takeya Minami, Yoshihiro Kuwabara, Koichiro Kuwahara, Izuru Masuda, Kenji Kangawa, Naoto Minamino, Kazuwa Nakao
BACKGROUND: Recent studies have shown that in addition to brain (or B-type) natriuretic peptide (BNP) and the N-terminal proBNP fragment, levels of intact proBNP are also increased in heart failure. Moreover, present BNP immunoassays also measure proBNP, as the anti-BNP antibody cross-reacts with proBNP. It is important to know the exact levels of proBNP in heart failure, because elevation of the low-activity proBNP may be associated with the development of heart failure. METHODOLOGY/PRINCIPAL FINDINGS: We therefore established a two-step immunochemiluminescent assay for total BNP (BNP+proBNP) and proBNP using monoclonal antibodies and glycosylated proBNP as a standard...
2013: PloS One
https://www.readbyqxmd.com/read/22648735/exercise-preconditioning-provides-early-cardioprotection-against-exhaustive-exercise-in-rats-potential-involvement-of-protein-kinase-c-delta-translocation
#20
Yu-Jun Shen, Shan-Shan Pan, Jun Ge, Zhe Hao
The objective of this study was to investigate the early cardioprotective effect of exercise preconditioning (EP) on the exhaustive exercise-induced myocardial injury in rats and the role of protein kinase C delta isoform (PKCδ) in EP. Rats were subjected to run on the treadmill for four periods of 10 min each at 30 m/min with intervening periods of rest of 10 min as an EP protocol. The exhaustive exercise was performed 0.5 h after EP. PKC inhibitor chelerythrine (CHE) was injected before EP. Our results showed that EP markedly attenuated the exhaustive exercise-induced myocardial ischemia/hypoxia, ultrastructural damage, high serum cTnI, and NT-proBNP levels...
September 2012: Molecular and Cellular Biochemistry
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