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https://www.readbyqxmd.com/read/29356462/a-randomized-multicenter-clinical-trial-of-99-tc-methylene-diphosphonate-in-treatment-of-rheumatoid-arthritis
#1
Rong Mu, Jun Liang, Lingyun Sun, Zhuoli Zhang, Xiangyuan Liu, Cibo Huang, Ping Zhu, Xiaoxia Zuo, Jieruo Gu, Xiangpei Li, Xingfu Li, Yi Liu, Ping Feng, Zhanguo Li
AIM: To investigate the efficacy and safety of technetium-99 conjugated with methylene diphosphonate (99 Tc-MDP, Yunke Pharmaceutical industry) in the treatment of rheumatoid arthritis (RA). METHODS: A total of 120 patients with active RA were randomly divided into three groups: Group A (receiving oral meloxicam tablets); Group B (receiving intravenous drip of 99 TC-MDP); Group C (receiving combination treatment of intravenous drip of 99 Tc-MDP and oral meloxicam tablets)...
January 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29356459/costs-of-immune-responses-are-related-to-host-body-size-and-lifespan
#2
Amber J Brace, Marc J Lajeunesse, Daniel R Ardia, Dana M Hawley, James S Adelman, Katherine L Buchanan, Jeanne M Fair, Jennifer L Grindstaff, Kevin D Matson, Lynn B Martin
A central assumption in ecological immunology is that immune responses are costly, with costs manifesting directly (e.g., increases in metabolic rate and increased amino acid usage) or as tradeoffs with other life processes (e.g., reduced growth and reproductive success). Across taxa, host longevity, timing of maturity, and reproductive effort affect the organization of immune systems. It is reasonable, therefore, to expect that these and related factors should also affect immune activation costs. Specifically, species that spread their breeding efforts over a long lifetime should experience lower immune costs than those that mature and breed quickly and die comparatively early...
June 2017: Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology
https://www.readbyqxmd.com/read/29356457/seasonal-variation-and-correlation-between-corticosterone-and-the-antioxidant-uric-acid-during-stress-in-the-northern-cardinal-cardinalis-cardinalis
#3
Jonathan W Haskins, Frank A Spizzoucco, Brian G Walker
Glucocorticoids modify metabolism and other physiological processes in order to mount an appropriate response to stress. This stress response is affected by a combination of seasonal changes, life-history events, and environmental factors. Determining seasonal variability and the potential connection between stress hormones and metabolism is fundamental in understanding seasonal physiological changes in animals. Here, we compared an indicator of stress (corticosterone) with an indicator of metabolic activity (uric acid-a non-enzymatic antioxidant and end product of protein metabolism) during capture and restraint in Northern Cardinals (Cardinalis cardinalis) during fall, winter, spring, and summer...
July 2017: Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology
https://www.readbyqxmd.com/read/29356444/physiological-plasticity-in-lizard-embryos-exposed-to-high-altitude-hypoxia
#4
Gerardo A Cordero, Bea Angelica Andersson, Jeremie Souchet, Gaëlle Micheli, Daniel W A Noble, Eric J Gangloff, Tobias Uller, Fabien Aubret
Coping with novel environments may be facilitated by plastic physiological responses that enable survival during environmentally sensitive life stages. We tested the capacity for embryos of the common wall lizard (Podarcis muralis) from low altitude to cope with low-oxygen partial pressure (hypoxia) in an alpine environment. Developing embryos subjected to hypoxic atmospheric conditions (15-16% O2 sea-level equivalent) at 2,877 m above sea level exhibited responses common to vertebrates acclimatized to or evolutionarily adapted to high altitude: suppressed metabolism, cardiac hypertrophy, and hyperventilation...
August 2017: Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology
https://www.readbyqxmd.com/read/29356430/morph-specific-metabolic-rate-and-the-timing-of-reproductive-senescence-in-a-color-polymorphic-dragon
#5
Christopher R Friesen, Rasmus Johansson, Mats Olsson
Polymorphism has fascinated biologists for over a century because morphs persist within populations through evolutionary time in spite of showing disparate behavioral and physiological phenotypes; any one morph should go to fixation with the slightest fitness advantage over the others. Surely there must be trade-offs that balance selection on them. The polychromatic morphs of the Australian painted dragon lizard, Ctenophorus pictus, are one such system. The male color morphs of painted dragons have different physiological and behavioral traits including reproductive tactics, hormone levels, and the rate of body condition loss through the reproductive season...
August 2017: Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology
https://www.readbyqxmd.com/read/29356379/metabolic-plasticity-in-development-synergistic-responses-to-high-temperature-and-hypoxia-in-zebrafish-danio-rerio
#6
Tien-Chien Francis Pan, Ione Hunt von Herbing
This study investigated interactions of temperature and hypoxia on metabolic plasticity and regulation in zebrafish, Danio rerio, in the first week of development. Larval morphometry, oxygen consumption, and metabolic responses to acute changes in temperature and oxygen were measured in larvae reared under four conditions, including control (28°C and partial pressures of oxygen [PO2] of 21 kPa), high temperature (31°C), hypoxia (11 kPa), and the two stressors combined. Rearing conditions did not result in consistent morphometric changes; substantial metabolic adjustments, however, were evident...
April 2017: Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology
https://www.readbyqxmd.com/read/29356375/molecular-characterization-and-tissue-expression-profiles-of-prepro-vasoactive-intestinal-peptide-in-the-chinese-alligator-alligator-sinensis-during-the-active-and-hibernating-periods
#7
Sheng-Zhou Zhang, Ting Meng, Xue Zhu, Huan Wang, Yong-Kang Zhou, Xiao-Bing Wu
The Chinese alligator (Alligator sinensis), a freshwater crocodilian endemic to China, is one of the most endangered crocodilian species; up to this date, very little is known about the endocrine regulation of its metabolic activities during different physiological states. In this study, we characterized the structure of the prepro-vasoactive intestinal peptide in Chinese alligator (prepro-caVIP) for the first time and examined its expression profiles in various tissues during the active and hibernating periods...
February 2017: Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology
https://www.readbyqxmd.com/read/29356356/phase-angle-measured-by-electrical-bioimpedance-and-global-cardiovascular-risk-in-older-adults
#8
Maria An Saad, Antonio Jl Jorge, Wolney de Andrade Martins, Gilberto P Cardoso, Marcia Ms Dos Santos, Maria Lg Rosa, Giovanna Ab Lima, Rafaela Q de Moraes, Rubens A da Cruz Filho
AIM: Population aging is a worldwide phenomenon associated with physiological and metabolic changes that contribute to the increased prevalence of risk factors for cardiovascular disease. The phase angle (PA) is a variable calculated by bioelectrical impedance analysis, interpreted as a direct measure of cell stability. The objective of the present study was to investigate the correlation of PA with the anthropometric measures, metabolic profile and the cardiovascular risk estimated by the Global Cardiovascular Risk Score in the elderly population...
January 22, 2018: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29356345/four-days-of-simulated-shift-work-reduces-insulin-sensitivity-in-humans
#9
R Bescos, M J Boden, M L Jackson, A J Trewin, E C Marin, I Levinger, A Garnham, D S Hiam, F Falcao-Tebas, F Conte, J A Owens, D J Kennaway, G K McConell
AIM: The aim of this study was to investigate the effects of four consecutive simulated night shifts on glucose homeostasis, mitochondrial function and central and peripheral rhythmicity compared with a simulated day shift schedule. METHODS: Seventeen healthy adults (8M:9F) matched for sleep, physical activity, and dietary/fat intake participated in this study (night shift work n= 9; day shift work n= 8). Glucose tolerance and insulin sensitivity before and after 4 nights of shift work were measured by an intravenous glucose tolerance test and a hyperinsulinemic euglycemic clamp, respectively...
January 22, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29356341/cryopreserved-neonatal-hepatocytes-may-be-a-source-for-transplantation-evaluation-of-functionality-towards-clinical-use
#10
Charlotte A Lee, Anil Dhawan, Valeria Iansante, Sharon Lehec, Shirin Elizabeth Khorsandi, Celine Filippi, Simon Walker, Raquel Fernandez-Dacosta, Nigel Heaton, Sanjay Bansal, Ragai R Mitry, Emer Fitzpatrick
Neonatal livers are a potential source of good quality hepatocytes for clinical transplantation. We compared viability and function of neonatal and adult hepatocytes, and report their clinical use both intra-portally and in alginate microbeads. Following isolation from donor livers, hepatocyte function was assessed using albumin, alpha-1 antitrypsin and factor VII. Metabolic function was investigated by measuring resorufin conjugation, ammonia metabolism, UGT enzyme activity and cytochrome P450 function following induction...
January 21, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29356327/functions-of-autophagy-in-the-tumor-microenvironment-and-cancer-metastasis
#11
REVIEW
Erin E Mowers, Marina N Sharifi, Kay F MacLeod
Macro-autophagy is an ancient and highly-conserved self-degradative process that plays a homeostatic role in normal cells by eliminating organelles, pathogens and protein aggregates. Autophagy, as it is routinely referred to, also allows cells to maintain metabolic sufficiency and survive under conditions of nutrient stress by recycling the by-products of autophagic degradation, such as fatty acids, amino acids and nucleotides. Tumor cells are more reliant than normal cells on autophagy for survival in part due to their rapid growth rate, altered metabolism and nutrient deprived growth environment...
January 21, 2018: FEBS Journal
https://www.readbyqxmd.com/read/29356310/adaptive-evolution-in-the-coccolithophore-gephyrocapsa-oceanica-following-1000-generations-of-selection-under-elevated-co2
#12
Shanying Tong, Kunshan Gao, David A Hutchins
Coccolithophores are important oceanic primary producers not only in terms of photosynthesis, but also because they produce calcite plates called coccoliths. Ongoing ocean acidification associated with changing seawater carbonate chemistry may impair calcification and other metabolic functions in coccolithophores. While short-term ocean acidification effects on calcification and other properties have been examined in a variety of coccolithophore species, long-term adaptive responses have scarcely been documented, other than for the single species Emiliania huxleyi...
January 22, 2018: Global Change Biology
https://www.readbyqxmd.com/read/29356306/evidence-of-interaction-between-genes-in-the-folate-homocysteine-metabolic-pathway-in-controlling-risk-of-nonsyndromic-oral-cleft
#13
Ping Wang, Tao Wu, Holger Schwender, Hong Wang, Bing Shi, Zhuqing Wang, Yuan Yuan, Dongjing Liu, Mengying Wang, Jing Li, Zhibo Zhou, Hongping Zhu, Terri H Beaty
OBJECTIVE: Little consistent evidence is available for the association between the risk of nonsyndromic cleft lip with or without cleft palate (NSCL/P) and any of the individual genes in the folate/homocysteine metabolic pathway. We investigated the genes in the folate pathway to further clarify its potential influence on the risk of NSCL/P considering gene-gene (G×G) interaction. SUBJECTS AND METHODS: We selected markers in 18 genes from the pathway and applied the Cordell's method to test for G×G interaction using 1,908 NSCL/P case-parent trios ascertained in an international consortium where a genome-wide association study (GWAS) of oral clefts was conducted...
January 22, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29356302/fast-publication-a-must-for-a-journal
#14
EDITORIAL
Paolo Pozzilli
As Diabetes/Metabolism: Research & Reviews (DMRR) begins its transition to a new editorial team, incoming Editor-in-Chief, Dr Paolo Pozzilli, reflects on the lessons learned from the past editorship and envisions the future of the journal. In today's fast-paced world, a medical journal should be fast in communicating decisions. Authors are eager to publish their work as fast as possible, and a journal must guarantee this, whilst at the same time ensuring a rigorous peer-review process. With this in mind, we hope to help the diabetes scientific community...
January 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29356299/testosterone-a-key-factor-in-gender-related-metabolic-syndrome
#15
REVIEW
V E Bianchi, V Locatelli
Metabolic syndrome (MetS) is highly correlated with cardiovascular diseases. Although an excess of body fat is a determinant factor for MetS development, a reduced level of testosterone plays a fundamental role in its regulation. Low testosterone level is highly related to insulin resistance, visceral obesity and MetS. We have searched in Pubmed clinical trial with the password: testosterone and insulin resistance, and testosterone and MetS. We found 19 studies on the correlation between testosterone level with insulin resistance and 18 on the effect of testosterone therapy on MetS...
January 21, 2018: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29356296/beyond-pathways-genetic-dissection-of-tocopherol-content-in-maize-kernels-by-combining-linkage-and-association-analyses
#16
Hong Wang, Shutu Xu, Yaming Fan, Nannan Liu, Wei Zhan, Haijun Liu, Yingjie Xiao, Kun Li, Qingchun Pan, Wenqiang Li, Min Deng, Jie Liu, Min Jin, Xiaohong Yang, Jiansheng Li, Qing Li, Jianbing Yan
Although tocopherols play an important role in plants and animals, the genetic architecture of tocopherol content in maize kernels has remained largely unknown. In this study, linkage and association analyses were conducted to examine the genetic architecture of tocopherol content in maize kernels. Forty-one unique quantitative trait loci (QTLs) were identified by linkage mapping in six populations of recombinant inbred lines (RILs). In addition, 32 significant loci were detected via genome-wide association study (GWAS), 18 of which co-localized with the QTLs identified by linkage mapping...
January 21, 2018: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/29356227/efficacy-of-peritoneal-dialysis-in-neonates-presenting-with-hyperammonaemia-due-to-urea-cycle-defects-and-organic-acidaemia
#17
Muhittin Celik, Osman Akdeniz, Nezir Ozgun
AIM: Newborns with inborn errors of metabolism can present with hyperammonaemic coma. In this study, we evaluated the effect of peritoneal dialysis on plasma ammonium levels and on the short-term outcome in neonatal patients with urea cycle defects and organic acidaemia. METHODS: Data from infants with hyperammonaemia due to urea cycle defects or organic acidaemia treated with dialysis were collected and retrospectively analysed. The results of patient groups (group I, survived; and group II, died) were compared...
January 22, 2018: Nephrology
https://www.readbyqxmd.com/read/29356205/antiviral-potential-of-medicinal-plants-against-hiv-hsv-influenza-hepatitis-and-coxsackievirus-a-systematic-review
#18
REVIEW
Muhammad Akram, Imtiaz Mahmood Tahir, Syed Muhammad Ali Shah, Zahed Mahmood, Awais Altaf, Khalil Ahmad, Naveed Munir, Muhammad Daniyal, Suhaila Nasir, Huma Mehboob
Viral infections are being managed therapeutically through available antiviral regimens with unsatisfactory clinical outcomes. The refractory viral infections resistant to available antiviral drugs are alarming threats and a serious health concern. For viral hepatitis, the interferon and vaccine therapies solely are not ultimate solutions due to recurrence of hepatitis C virus. Owing to the growing incidences of viral infections and especially of resistant viral strains, the available therapeutic modalities need to be improved, complemented with the discovery of novel antiviral agents to combat refractory viral infections...
January 22, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29356175/radioprotective-effects-of-dammarane-sapogenins-against-60-co-induced-myelosuppression-in-mice
#19
Liming Dong, Yanyan Yang, Yan Lu, Cong Lu, Jingwei Lv, Ning Jiang, Qiuxia Xu, Yue Gao, Qi Chang, Xinmin Liu
Radiotherapy frequently induces failure of hematopoietic system and leads to myelosuppression. The objective of this study was to investigate the protective effect of dammarane sapogenins (DS), the hydrolysed product of the constituent ginsenosides of Panax ginseng, which are produced by gut metabolism, on radiation-induced hematopoietic injury. Mice were exposed to 3.5 Gy 60 Co γ-rays of total body radiation at a dose rate of 1.60 Gy per minute and treated with DS or granulocyte colony-stimulating factor immediately after radiation...
January 22, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29356155/metabolic-study-of-dioecy-in-mauritia-flexuosa-nmr-based-and-chemometric-approaches
#20
Deisy Dos Santos Freitas, Glaucia Braz Alcantara
INTRODUCTION: Mauritia flexuosa is a dioecious species native to the Amazon, and the gender identification can currently be determined through the differentiation between female and male flowers in the first flowering. OBJECTIVES: To identify variations in the metabolome profiles of pooled and individual samples of leaves from female and male plants of M. flexuosa in reproductive phase, and the plant in its vegetative phase, using two extraction systems. MATERIAL AND METHODS: Extractions of leaves were separately conducted using deuterated water and methanol...
January 21, 2018: Phytochemical Analysis: PCA
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