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https://www.readbyqxmd.com/read/28945044/-effect-of-qishen-yiqi-droplet-on-adenylate-contents-in-myocardium-of-cor-pulmonale-rats
#1
Shi-Han Geng, Qiu-Yue Shan, Meng-Xi Xu, Yi-Dan Zhang, Li-Li Song, Ning Hou, Wen Zhang, Mi-Xia Zhang, Peng-Wei Zhuang, Yan-Jun Zhang
Cor pulmonale rat models were induced by a single intraperitoneal injection of monocrotaline(MCT), and the sham group received a single intraperitioneal injection of normal saline. After the model rats received intragastric administration of Qishen Yiqi droplet(QS) for 6 weeks, the contents of adenylate(ATP, ADP and AMP) in right myocardial tissues were measured by HPLC, and then the metabolism changes in myocardium of cor pulmonale rats with QS were investigated. The results showed that ATP, ADP, and AMP were well separated, with a good linearity within a certain range of concentration; and the recovery rates were within the range of 90%-108%...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28945041/-dynamic-serum-metabolomics-study-of-liver-injury-in-rats-caused-by-polygonum-multifulorum
#2
Zhi-Jie Ma, Qi Li, Kui-Jun Zhao, Jia-Bo Wang, Xiao-He Xiao
Liquid chromatography-mass spectrometry method was used for determination of metabolic fingerprint spectrum in rat serum, and the method of multivariate statistical analysis was used to compare the metabolism spectrum difference and screen significantly related biomarkers. The dynamic change trend was investigated at the same time. The dynamic metabonomics changes of liver injury in rats caused by Polygonum multifulorum(PM) were investigated; significantly related biomarkers were found and their dynamic change trend was investigated to provide basis for internal mechanism and early clinical diagnosis...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28945020/-a-phytochemical-and-pharmacological-advance-on-ilex-asprella
#3
REVIEW
Bing-Zhao Du, Xin-Yao Yang, Xiao Feng, Xu Yin, He-Xin-Ge Zhang, Feng Zhao, Zeng-Ping Gao, Peng-Fei Tu, Xing-Yun Chai
Ilex asprella is one of representative medicinal plants in South of the Five Ridges of China. The roots and rhizomes of I. asprella have the effects of clearing heat and detoxifying, stimulating salvia, and reducing thirst, which has been used to treat wind-heat cold, acute and chronic pharyngitis, and sore throat. Contemporary studies showed that I. asprella contains the major triterpenoids and glycosides, phenolic acids, and minor steroids. The extracts and compounds show activities of anti-inflammatory, antiviral, anti-tumor, and regulating lipid metabolism...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28945011/prediction-of-drug-drug-interaction-between-tacrolimus-and-principal-ingredients-of-wuzhi-capsule-in-chinese-healthy-volunteers-using-physiologically-based-pharmacokinetic-modelling
#4
Hongyan Zhang, Fengjiao Bu, Lei Li, Zheng Jiao, Guo Ma, Weimin Cai, Xiaomei Zhuang, Hai-Shu Lin, Jae-Gook Shin, Xiaoqiang Xiang
Schisantherin A and schisandrin A, the most abundant active ingredients of Wuzhi capsule, are known to inhibit tacrolimus metabolism by inhibiting CYP3A4/5. We aimed to predict the contribution of schisantherin A and schisandrin A to drug-drug interaction (DDI) between Wuzhi capsule and tacrolimus using physiologically-based pharmacokinetic (PBPK) modelling. Firstly, the inhibition mechanism of schisantherin A and schisandrin A on CYP3A4/5 were investigated. Thereafter, PBPK models of schisantherin A, schisandrin A and tacrolimus were established...
September 25, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28944995/comparative-analysis-of-serum-proteome-in-congenital-scoliosis-patients-with-tbx6-haploinsufficiency-a-first-report-pointing-to-lipid-metabolism
#5
Qiankun Zhu, Nan Wu, Gang Liu, Yangzhong Zhou, Sen Liu, Jun Chen, Jiaqi Liu, Yuzhi Zuo, Zhenlei Liu, Weisheng Chen, Yixin Chen, Jia Chen, Mao Lin, Yanxue Zhao, Yang Yang, Shensgru Wang, Xu Yang, Yufen Ma, Jian Wang, Xiaoli Chen, Jianguo Zhang, Jianxiong Shen, Zhihong Wu, Guixing Qiu
Congenital scoliosis (CS) is a three-dimensional deformity of the spine affecting quality of life. We have demonstrated TBX6 haploinsufficiency is the most important contributor to CS. However, the pathophysiology at the protein level remains unclear. Therefore, this study was to explore the differential proteome in serum of CS patients with TBX6 haploinsufficiency. Sera from nine CS patients with TBX6 haploinsufficiency and nine age- and gender-matched healthy controls were collected and analysed by isobaric tagged relative and absolute quantification (iTRAQ) labelling coupled with mass spectrometry (MS)...
September 25, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28944989/the-combination-of-valsartan-and-sacubitril-in-the-treatment-of-hypertension-and-heart-failure-an-update
#6
Peter Munch Nielsen, Daniela Grimm, Markus Wehland, Ulf Simonsen, Marcus Krüger
A novel antihypertensive drug, LCZ696 (Entresto(®) ), has recently been introduced, which combines the action of an antagonist of the renin-angiotensin-aldosterone-system (RAAS), effectively decreasing the blood pressure, with an inhibition of neprilysin, which is responsible for metabolizing natriuretic peptides exerting anti-hypertensive and anti-fibrotic effects. In this MiniReview, we describe the pharmacokinetics and -dynamics, efficacy and side effects of the combined angiotensin receptor antagonist and neprilysin inhibitor LCZ696...
September 25, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28944982/evaluation-of-inos-inhibition-on-kidney-function-and-structure-in-high-fat-diet-induced-kidney-disease
#7
Blanche Martin, Nathalie Caron, Inès Jadot, Vanessa Colombaro, Gabrielle Federici, Clara Depommier, Anne-Émilie Declèves
BACKGROUND: Central obesity is related to caloric excess promoting deleterious cellular responses in targeted organs. Nitric oxide (NO) has been determined as a key player in the pathogenesis of metabolic diseases. Here, we investigated the implication of inducible NO synthase (iNOS) in the development of obesity-induced kidney disease. MATERIALS AND METHODS: C57Bl/6 male mice were randomized to a low-fat diet (LFD) or a high-fat diet (HFD) and treated with L-NIL, a specific iNOS inhibitor for 16 weeks...
September 25, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28944920/periodic-acid%C3%A2-schiff-staining-method-for-function-detection-of-liver-cells-is-affected-by-2-horse-serum-in-induction-medium
#8
Hui Hui, Wenjun Ma, Jiejie Cui, Mengjia Gong, Yi Wang, Yuanyuan Zhang, Tongchuan He, Yang Bi, Yun He
Developing a thorough understanding of experimental methods of hepatic differentiation in hepatic progenitor cells (HPCs) should expand the knowledge of hepatocyte induction in vitro and may help to develop cell transplantation therapies for the clinical usage of HPCs in liver diseases. A previous induction method effectively induced differentiation and metabolic abilities in HPCs. Periodic acid‑Schiff (PAS) staining is used to identify glycogen synthesis and hepatocyte function; however, this method failed to detect induced hepatocytes...
September 22, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944913/oleanolic-acid-alleviates-diabetic-rat-carotid-artery-injury-through-the-inhibition-of-nlrp3-inflammasome-signaling-pathways
#9
Qian An, Qian Hu, Bing Wang, Wenjun Cui, Fei Wu, Yu Ding
The overexpression of inflammasome components is correlated with diabetes‑associated complications. Oleanolic acid is a triterpenoid compound which is important in arterial injury. The present study evaluated whether oleanolic acid improved diabetic rat carotid artery injury through the inhibition of nucleotide‑binding domain, leucine‑rich‑containing family, pyrin domain‑containing‑3 (NLRP3) inflammasomes signaling pathways. A diabetic rat model was induced using streptozotocin (60 mg/kg) and underwent carotid artery injury...
September 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944894/glucosylceramide-synthase-regulates-the-proliferation-and-apoptosis-of-liver-cells-in%C3%A2-vitro-by-bcl%C3%A2-2-bax-pathway
#10
Jun-Feng Li, Su-Jun Zheng, Li-Li Wang, Shuang Liu, Feng Ren, Yu Chen, Li Bai, Mei Liu, Zhong-Ping Duan
Our previous study found that glucosylceramide, a type of sphingolipids, was associated with liver inflammation and fibrosis. Glucosylceramide is generated by glucosylceramide synthase (GCS), which is encoded by the UDP‑glucose ceramide glucosyltransferase (UGCG) gene. GCS is a key enzyme to regulate the physiological activity of cells. However, the role of GCS in hepatic cells remains unclear. The aim of the present study was to explore the mechanism of GCS in the proliferation and apoptosis of liver cells...
September 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944880/edoxaban-improves-venous-thrombosis-via-increasing-hydrogen-sulfide-and-homocysteine-in-rat-model
#11
Wei Song, Hongbo Ci, Guanglei Tian, Yanjun Zhang, Xiaohu Ge
Anticoagulant therapy is prescribed to millions of patients worldwide for the prevention and treatment of venous thrombosis. Evidence has indicated that edoxaban is a potential drug of oral anticoagulant in the acute treatment of venous thromboembolism. Hydrogen sulfide and homocysteine plasma concentration are indicators of cardiovascular and neurovascular disease risk factors that have attracted considerable attention for regulation of vascular health and homeostasis. However, the molecular mechanism of edoxaban‑mediated differences of hydrogen sulfide and homocysteine has not been investigated in the progression of venous thrombosis...
September 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944878/gene-expression-analysis-regulation-of-key-genes-associated-with-mycophenolate-mofetil-treatment-of-symptomatic-carotid-artery-stenosis
#12
Feng Jin, Kai Wang, Xiaochuan Sun, Zhanpu Zhang, Ping Han
The present study analyzed gene expression arrays to identify differentially-expressed genes (DEGs) between mycophenolate mofetil (MMF)‑treated and placebo‑treated patients with symptomatic carotid artery stenosis (SCAS). In addition, the key genes involved in the pharmacology of MMF treatment in patients with SCAS were identified. The gene expression dataset was obtained from a Gene Expression Omnibus database, which included 9 MMF‑treated and 11 placebo‑treated samples. The DEGs were identified between MMF and placebo groups using R software...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944856/systemic-overexpression-of-the-11%C3%AE-%C3%A2-hsd1-promotes-endoplasmic-reticulum-stress-in-multiple-tissues-and-the-development-of-metabolic-syndrome-in-mice
#13
Chenxiao Li, Jihan Xia, Wenjuan Zhu, Leilei Xin, Cuiping An, Shulin Yang, Kui Li
Glucocorticoids are associated with lipid metabolism and their abnormal expression has an important function in the development of metabolic syndrome. The 11β‑hydroxysteroid dehydrogenase type 1 (11β‑HSD1) is a metabolic enzyme of glucocorticoids and may be a potential drug target for the treatment of metabolic syndrome. However, the association between the systemic expression of 11β‑HSD1 and metabolic syndrome remains to be elucidated. The present study used a cytomegalovirus promoter to obtain mice that systemically overexpressed the 11β‑HSD1 gene...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944830/application-of-the-amniotic-fluid-metabolome-to-the-study-of-fetal-malformations-using-down-syndrome-as-a-specific-model
#14
Jun Huang, Jinhua Mo, Guili Zhao, Qiyin Lin, Guanhui Wei, Weinan Deng, Dunjin Chen, Bolan Yu
Although monitoring and diagnosis of fetal diseases in utero remains a challenge, metabolomics may provide an additional tool to study the etiology and pathophysiology of fetal diseases at a functional level. In order to explore specific markers of fetal disease, metabolites were analyzed in two separate sets of experiments using amniotic fluid from fetuses with Down syndrome (DS) as a model. Both sets included 10‑15 pairs of controls and cases, and amniotic fluid samples were processed separately; metabolomic fingerprinting was then conducted using UPLC‑MS...
September 18, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944807/conjugated-fatty-acid-rich-oil-from-gynostrmma-pentaphyllum-seed-can-ameliorate-lipid-and-glucose-metabolism-in-type-2-diabetes-mellitus-mice
#15
Mingxing Zhang, Nan Du, Lu Wang, Xiaobing Wang, Yaping Xiao, Kun Zhang, Quanhong Liu, Pan Wang
Gynostrmma pentaphyllum seed oil (GPSO), extracted from G. pentaphyllum seeds, is rich in conjugated linolenic acid, which is a special fatty acid consisting of cis-9, trans-11, trans-13 isomers. Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia resulting from insulin resistance, and is usually accompanied by hypertension, hyperlipidemia, atherosclerosis (i.e., the metabolic syndrome, or syndrome X), and polycystic ovarian disease. This study aimed to investigate the effect of GPSO on T2DM hepatic lipid metabolism and the underlying mechanism involving level of protein expression...
September 25, 2017: Food & Function
https://www.readbyqxmd.com/read/28944798/transcriptomic-analysis-of-bama-pig-s-liver-in-various-nutritional-states-reveals-a-metabolic-difference-of-fatty-acids
#16
Yixing Li, Yi Chu, Lin Yu, Huifang Kang, Lei Zhou
Both fasting and treatment with a high-fat diet (HFD) can dramatically change fat metabolism in the liver and, thus, are commonly used methods to investigate hepatic fat metabolism and related diseases. Here, the gene expression profiles of pig liver under both conditions were investigated and changes in hepatic triacylglycerol (TG) levels under different diet conditions were determined. In this study, both fasting and HFD conditions significantly increased hepatic TG levels and serum levels of cholesterol, TG, high-density lipoprotein, low-density lipoprotein, and apolipoprotein B...
September 25, 2017: Food & Function
https://www.readbyqxmd.com/read/28944771/the-spectrum-of-t-cell-metabolism-in-health-and-disease
#17
REVIEW
Glenn R Bantug, Lorenzo Galluzzi, Guido Kroemer, Christoph Hess
In healthy individuals, metabolically quiescent T cells survey lymph nodes and peripheral tissues in search of cognate antigens. During infection, T cells that encounter cognate antigens are activated and - in a context-specific manner - proliferate and/or differentiate to become effector T cells. This process is accompanied by important changes in cellular metabolism (known as metabolic reprogramming). The magnitude and spectrum of metabolic reprogramming as it occurs in T cells in the context of acute infection ensure host survival...
September 25, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28944751/fitness-costs-of-plasmids-a-limit-to-plasmid-transmission
#18
Alvaro San Millan, R Craig MacLean
Plasmids mediate the horizontal transmission of genetic information between bacteria, facilitating their adaptation to multiple environmental conditions. An especially important example of the ability of plasmids to catalyze bacterial adaptation and evolution is their instrumental role in the global spread of antibiotic resistance, which constitutes a major threat to public health. Plasmids provide bacteria with new adaptive tools, but they also entail a metabolic burden that, in the absence of selection for plasmid-encoded traits, reduces the competitiveness of the plasmid-carrying clone...
September 2017: Microbiology Spectrum
https://www.readbyqxmd.com/read/28944745/obesity-a-possible-risk-factor-for-restless-legs-syndrome
#19
Demet Yildiz, Nilufer Buyukkoyuncu, Ahmet Kasim Kilic, Soner Cander, Abdülmecit Yıldız, Aygul Gunes, Meral Seferoglu, Sevda Erer Ozbek
AIM/BACKGROUND: Restless legs syndrome (RLS) is a frequent neurological and sleep disorder. Metabolic disorders are known to be related to sleep disorders. We prospectively evaluated whether obesity and its possible cofactors were related to the presence of RLS. MATERIALS AND METHODS: The study included 143 obese and 94 non-obese individuals. Obese patients had a BMI of 30 and over, while non-obese patients had a BMI lower than 30. Patients with arthritis and pregnancy were excluded but not those with diabetes mellitus...
September 25, 2017: Neurological Research
https://www.readbyqxmd.com/read/28944709/the-cardiometabolic-effect-of-current-management-of-polycystic-ovary-syndrome-strategies-of-prevention-and-treatment
#20
Dinka Pavicic Baldani, Lana Skrgatic, Roya Ougouag, Miro Kasum
Polycystic ovary syndrome (PCOS) is the commonest endocrine disorder amongst women of reproductive age, which is characterized by reproductive and cardiometabolic disturbances with long-term health repercussions. Insulin resistance (IR), impaired glucose tolerance, type 2 diabetes mellitus (DM2), obesity and dyslipidemia occur more in women with PCOS than in age-comparable women without PCOS. Long term data regarding risks or benefits of medical intervention for metabolic dysfunction of PCOS are lacking. Therapies, such as oral contraceptives (OCPs) and anti-androgenic medications used to manage the reproductive manifestations of PCOS, may themselves be the cause of cardiometabolic perturbations...
September 23, 2017: Gynecological Endocrinology
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