Keisuke Kohama, Atsunori Nakao, Mariko Terashima, Michiko Aoyama-Ishikawa, Takayuki Shimizu, Daisuke Harada, Mitsuo Nakayama, Hayato Yamashita, Mayu Fujiwara, Joji Kotani
Fish oil rich in n-3 polyunsaturated fatty acids has diverse immunomodulatory properties and attenuates acute lung injury when administered in enternal nutrition. However, enteral nutrition is not always feasible. Therefore, we investigated the ability of parenteral nutrition supplemented with fish oil to ameliorate acute lung injury. Rats were infused with parenteral nutrition solutions (without lipids, with soybean oil, or with soybean oil and fish oil) for three days. Lipopolysaccharide (15 mg/kg) was then administered intratracheally to induce acute lung injury, characterized by impaired lung function, polymorphonuclear leukocyte recruitment, parenchymal tissue damage, and upregulation of mRNAs for inflammatory mediators...
March 2014: Journal of Clinical Biochemistry and Nutrition