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https://www.readbyqxmd.com/read/29925950/epigenetic-inheritance-mediated-by-coupling-of-rnai-and-histone-h3k9-methylation
#1
Ruby Yu, Xiaoyi Wang, Danesh Moazed
Histone post-translational modifications (PTMs) are associated with epigenetic states that form the basis for cell-type-specific gene expression1,2 . Once established, histone PTMs can be maintained by positive feedback involving enzymes that recognize a pre-existing histone modification and catalyse the same modification on newly deposited histones. Recent studies suggest that in wild-type cells, histone PTM-based positive feedback is too weak to mediate epigenetic inheritance in the absence of other inputs3-7 ...
June 20, 2018: Nature
https://www.readbyqxmd.com/read/29920263/transgenerational-inheritance-parental-guidance-suggested
#2
Douglas L Chalker
RNAs have been attractive candidates to transmit epigenetic information over multiple generations. In Tetrahymena, a new study demonstrates that the selective degradation of small RNAs that occurs by interaction with the parental genome can communicate altered patterns of heterochromatin formation and DNA elimination in offspring.
June 18, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29896789/transgenerational-inheritance-of-chronic-adolescent-stress-effects-of-stress-response-and-the-amygdala-transcriptome
#3
Melissa T Manners, Nicole L Yohn, Nicholas F Lahens, Gregory R Grant, Marisa S Bartolomei, Julie A Blendy
Adolescent stress can impact health and well-being not only during adulthood of the exposed individual but even in future generations. To investigate the molecular mechanisms underlying these long-term effects, we exposed adolescent males to stress and measured anxiety behaviors and gene expression in the amygdala - a critical region in the control of emotional states - in their progeny for two generations, offspring and grandoffspring. Male C57BL/6 mice underwent chronic unpredictable stress (CUS) for two-weeks during adolescence and were used to produce two generations of offspring...
June 13, 2018: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29896216/mir-155-and-mir-122-expression-of-spermatozoa-in-obese-subjects
#4
Paulina López, Andrea Castro, Martha Flórez, Karen Miranda, Pilar Aranda, Cristina Sánchez-González, Juan Llopis, Miguel Arredondo
Obesity is characterized by mild chronic inflammation that is linked with impaired iron homeostasis. Studies in human and murine show that there is a transgenerational epigenetic inheritance via the gametes in obesity; however, there is little information on changes in the expression of microRNAs related to inflammation and iron homeostasis in spermatozoa from obese subjects. The present study investigated the expression of microRNAs related to inflammation (miR-21 y miR-155) and iron nutrition (miR-122 and miR-200b) in plasma, peripheral blood mononuclear cells (PBMC) and spermatozoa from normozoospermic controls (Cn; n = 17; BMI: 24...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29887308/small-rna-mediated-trans-nuclear-and-trans-element-communications-in-tetrahymena-dna-elimination
#5
Tomoko Noto, Kazufumi Mochizuki
Epigenetic inheritance of acquired traits is widespread among eukaryotes, but how and to what extent such information is transgenerationally inherited is still unclear. The patterns of programmed DNA elimination in ciliates are epigenetically and transgenerationally inherited, and it has been proposed that small RNAs, which shuttle between the germline and the soma, regulate this epigenetic inheritance. In this study, we test the existence and role of such small-RNA-mediated communication by epigenetically disturbing the pattern of DNA elimination in Tetrahymena...
May 25, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29868581/a-decade-of-exploring-the-mammalian-sperm-epigenome-paternal-epigenetic-and-transgenerational-inheritance
#6
REVIEW
Alexandre Champroux, Julie Cocquet, Joëlle Henry-Berger, Joël R Drevet, Ayhan Kocer
The past decade has seen a tremendous increase in interest and progress in the field of sperm epigenetics. Studies have shown that chromatin regulation during male germline development is multiple and complex, and that the spermatozoon possesses a unique epigenome. Its DNA methylation profile, DNA-associated proteins, nucleo-protamine distribution pattern and non-coding RNA set up a unique epigenetic landscape which is delivered, along with its haploid genome, to the oocyte upon fertilization, and therefore can contribute to embryogenesis and to the offspring health...
2018: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29801514/intrauterine-hyperglycemia-exposure-results-in-intergenerational-inheritance-via-dna-methylation-reprogramming-on-f1-pgcs
#7
Jun Ren, Yi Cheng, Zhen-Hua Ming, Xin-Yan Dong, Yu-Zhong Zhou, Guo-Lian Ding, Hai-Yan Pang, Tanzil Ur Rahman, Rubab Akbar, He-Feng Huang, Jian-Zhong Sheng
BACKGROUND: The existing reports about intergenerational or transgenerational effects of intrauterine hyperglycemia have included both intrauterine and postnatal metabolic exposure factors, while the impact of intrauterine hyperglycemia per se has not been assessed alone. A number of studies suggest DNA methylation reprogramming of gametes plays a crucial role in the metabolic inheritance, but it is unclear when and how DNA methylation patterns are altered when exposed to intrauterine hyperglycemia...
May 25, 2018: Epigenetics & Chromatin
https://www.readbyqxmd.com/read/29791850/the-memory-of-environmental-chemical-exposure-in-c-elegans-is-dependent-on-the-jumonji-demethylases-jmjd-2-and-jmjd-3-utx-1
#8
Jessica Camacho, Lisa Truong, Zeyneb Kurt, Yen-Wei Chen, Marco Morselli, Gerardo Gutierrez, Matteo Pellegrini, Xia Yang, Patrick Allard
How artificial environmental cues are biologically integrated and transgenerationally inherited is still poorly understood. Here, we investigate the mechanisms of inheritance of reproductive outcomes elicited by the model environmental chemical Bisphenol A in C. elegans. We show that Bisphenol A (BPA) exposure causes the derepression of an epigenomically silenced transgene in the germline for 5 generations, regardless of ancestral response. Chromatin immunoprecipitation sequencing (ChIP-seq), histone modification quantitation, and immunofluorescence assays revealed that this effect is associated with a reduction of the repressive marks H3K9me3 and H3K27me3 in whole worms and in germline nuclei in the F3, as well as with reproductive dysfunctions, including germline apoptosis and embryonic lethality...
May 22, 2018: Cell Reports
https://www.readbyqxmd.com/read/29788325/ancestral-tcdd-exposure-induces-multigenerational-histologic-and-transcriptomic-alterations-in-gonads-of-male-zebrafish
#9
Danielle N Meyer, Bridget B Baker, Tracie R Baker
TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin), the classic AhR (aryl hydrocarbon receptor) agonist, is a potent environmental toxicant and endocrine-disrupting chemical (EDC) with known developmental toxicity in humans, rodents, and fish. Early life exposure to some EDCs, including TCDD, is linked to the occurrence of adult-onset and multigenerational disease. Previous work exposing juvenile F0 zebrafish (Danio rerio) to 50 ppt (parts per trillion) TCDD during reproductive development has shown male-mediated transgenerational decreases in fertility (F0-F2) and histological and transcriptomic alterations in F0 testes...
May 21, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29769721/spatiotemporal-regulation-of-liquid-like-condensates-in-epigenetic-inheritance
#10
Gang Wan, Brandon D Fields, George Spracklin, Aditi Shukla, Carolyn M Phillips, Scott Kennedy
Non-membrane-bound organelles such as nucleoli, processing bodies, Cajal bodies and germ granules form by the spontaneous self-assembly of specific proteins and RNAs. How these biomolecular condensates form and interact is poorly understood. Here we identify two proteins, ZNFX-1 and WAGO-4, that localize to Caenorhabditis elegans germ granules (P granules) in early germline blastomeres. Later in germline development, ZNFX-1 and WAGO-4 separate from P granules to define an independent liquid-like condensate that we term the Z granule...
May 16, 2018: Nature
https://www.readbyqxmd.com/read/29764658/transgenerational-effects-of-insecticides-implications-for-rapid-pest-evolution-in-agroecosystems
#11
REVIEW
Kristian Brevik, Leena Lindström, Stephanie D McKay, Yolanda H Chen
Although pesticides are a major selective force in driving the evolution of insect pests, the evolutionary processes that give rise to insecticide resistance remain poorly understood. Insecticide resistance has been widely observed to increase with frequent and intense insecticide exposure, but can be lost following the relaxation of insecticide use. One possible but rarely explored explanation is that insecticide resistance may be associated with epigenetic modifications, which influence the patterning of gene expression without changing underlying DNA sequence...
April 2018: Current Opinion in Insect Science
https://www.readbyqxmd.com/read/29750268/inferring-and-modeling-inheritance-of-differentially-methylated-changes-across-multiple-generations
#12
Pascal Belleau, Astrid Deschênes, Marie-Pier Scott-Boyer, Mathieu Dalvai, Janice Bailey, Arnaud Droit
High-throughput methylation sequencing enables genome-wide detection of differentially methylated sites (DMS) or regions (DMR). Increasing evidence suggests that treatment-induced DMS can be transmitted across generations, but the analysis of induced methylation changes across multiple generations is complicated by the lack of sound statistical methods to evaluate significance levels. Due to software design, DMS detection was usually made on each generation separately, thus disregarding stochastic effects expected when a large number of DMS is detected in each generation...
May 10, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29745724/radiosensitivity-and-transgenerational-effects-in-non-human-species
#13
C Adam-Guillermin, T Hertal-Aas, D Oughton, L Blanchard, F Alonzo, O Armant, N Horemans
The ALLIANCE working group on effects of ionising radiation on wildlife brings together European researchers to work on the topics of radiosensitivity and transgenerational effects in non-human biota. Differences in radiation sensitivity across species and phyla are poorly understood, but have important implications for understanding the overall effects of radiation and for radiation protection; for example, sensitive species may require special attention in monitoring and radiation protection, and differences in sensitivity between species also lead to overall effects at higher levels (community, ecosystem), since interactions between species can be altered...
January 1, 2018: Annals of the ICRP
https://www.readbyqxmd.com/read/29738444/the-effects-of-trauma-with-or-without-ptsd-on-the-transgenerational-dna-methylation-alterations-in-human-offsprings
#14
REVIEW
Nagy A Youssef, Laura Lockwood, Shaoyong Su, Guang Hao, Bart P F Rutten
Exposure to psychological trauma is a strong risk factor for several debilitating disorders including post-traumatic stress disorder (PTSD) and depression. Besides the impact on mental well-being and behavior in the exposed individuals, it has been suggested that psychological trauma can affect the biology of the individuals, and even have biological and behavioral consequences on the offspring of exposed individuals. While knowledge of possible epigenetic underpinnings of the association between exposure to trauma and risk of PTSD has been discussed in several reviews, it remains to be established whether trauma-induced epigenetic modifications can be passed from traumatized individuals to subsequent generations of offspring...
May 8, 2018: Brain Sciences
https://www.readbyqxmd.com/read/29732173/alterations-in-sperm-dna-methylation-non-coding-rna-expression-and-histone-retention-mediate-vinclozolin-induced-epigenetic-transgenerational-inheritance-of-disease
#15
Millissia Ben Maamar, Ingrid Sadler-Riggleman, Daniel Beck, Margaux McBirney, Eric Nilsson, Rachel Klukovich, Yeming Xie, Chong Tang, Wei Yan, Michael K Skinner
Epigenetic transgenerational inheritance of disease and phenotypic variation can be induced by several toxicants, such as vinclozolin. This phenomenon can involve DNA methylation, non-coding RNA (ncRNA) and histone retention, and/or modification in the germline (e.g. sperm). These different epigenetic marks are called epimutations and can transmit in part the transgenerational phenotypes. This study was designed to investigate the vinclozolin-induced concurrent alterations of a number of different epigenetic factors, including DNA methylation, ncRNA, and histone retention in rat sperm...
April 2018: Environmental Epigenetics
https://www.readbyqxmd.com/read/29732172/transgenerational-epigenetic-inheritance-in-birds
#16
REVIEW
Carlos Guerrero-Bosagna, Mireille Morisson, Laurence Liaubet, T Bas Rodenburg, Elske N de Haas, Ľubor Košťál, Frédérique Pitel
While it has been shown that epigenetics accounts for a portion of the variability of complex traits linked to interactions with the environment, the real contribution of epigenetics to phenotypic variation remains to be assessed. In recent years, a growing number of studies have revealed that epigenetic modifications can be transmitted across generations in several animal species. Numerous studies have demonstrated inter- or multi-generational effects of changing environment in birds, but very few studies have been published showing epigenetic transgenerational inheritance in these species...
April 2018: Environmental Epigenetics
https://www.readbyqxmd.com/read/29732171/pohad-why-we-should-study-future-fathers
#17
Adelheid Soubry
The growing field of 'Developmental Origin of Health and Disease' (DOHaD) generally reflects environmental influences from mother to child. The importance of maternal lifestyle, diet and other environmental exposures before and during gestation period is well recognized. However, few epidemiological designs explore potential influences from the paternal environment on offspring health. This is surprising given that numerous animal models have provided evidence that the paternal environment plays a role in a non-genetic inheritance of pre-conceptional exposures through the male germ line...
April 2018: Environmental Epigenetics
https://www.readbyqxmd.com/read/29727470/transgenerational-epigenetics-inheritance-of-global-cytosine-methylation-and-methylation-related-epigenetic-markers-in-the-shrub-lavandula-latifolia
#18
Carlos M Herrera, Conchita Alonso, Mónica Medrano, Ricardo Pérez, Pilar Bazaga
PREMISE OF THE STUDY: The ecological and evolutionary significance of natural epigenetic variation (i.e., not based on DNA sequence variants) variation will depend critically on whether epigenetic states are transmitted from parents to offspring, but little is known on epigenetic inheritance in nonmodel plants. METHODS: We present a quantitative analysis of transgenerational transmission of global DNA cytosine methylation (= proportion of all genomic cytosines that are methylated) and individual epigenetic markers (= methylation status of anonymous MSAP markers) in the shrub Lavandula latifolia...
April 2018: American Journal of Botany
https://www.readbyqxmd.com/read/29614954/bs-seeker3-ultrafast-pipeline-for-bisulfite-sequencing
#19
Kevin Yu Yuan Huang, Yan-Jiun Huang, Pao-Yang Chen
BACKGROUND: DNA methylation is an important epigenetic modification critical in regulation and transgenerational inheritance. The methylation level can be estimated at single-nucleotide resolution by whole-genome bisulfite sequencing (BS-seq; WGBS). Current bisulfite aligners provide pipelines for processing the reads by WGBS; however, few are able to analyze the BS-seqs in a reasonable timeframe that meets the needs of the rapid expansion of epigenome sequencing in biomedical research...
April 3, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/29593303/epigenetic-transgenerational-inheritance-of-altered-sperm-histone-retention-sites
#20
Millissia Ben Maamar, Ingrid Sadler-Riggleman, Daniel Beck, Michael K Skinner
A variety of environmental toxicants and factors have been shown to induce the epigenetic transgenerational inheritance of disease and phenotypic variation. Epigenetic alterations in the germline (sperm or egg) are required to transmit transgenerational phenotypes. The current study was designed to investigate the potential role of histones in sperm to help mediate the epigenetic transgenerational inheritance. The agricultural fungicide vinclozolin and the pesticide DDT (dichlorodiphenyltrichloroethane) were independently used to promote the epigenetic transgenerational inheritance of disease...
March 28, 2018: Scientific Reports
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