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Monika Rak, Anna Ochałek, Ewa Bielecka, Joanna Latasiewicz, Katarzyna Gawarecka, Jolanta Sroka, Jarosław Czyż, Katarzyna Piwowarczyk, Marek Masnyk, Marek Chmielewski, Tadeusz Chojnacki, Ewa Swiezewska, Zbigniew Madeja
BACKGROUND: One of the major challenges limiting development of gene therapy is absence of efficient and safe gene carriers. Among the non-viral gene delivery methods, lipofection is considered as one of the most promising. In this study a set of cationic polyprenyl derivatives (trimethylpolyprenylammonium iodides - PTAI) with different lengths of polyprenyl chains (from 7, 8 and 11 to 15 isoprene units) was suggested as a component of efficient DNA vehicles. METHODS: Optimization studies were conducted for PTAI in combination with co-lipid DOPE (dioleoylphosphatidylethanolamine) on DU145 human prostate cancer cells using: size and zeta potential measurements, confocal microscopy, fluorescein diacetate/ethidium bromide test, cell counting, time-lapse monitoring of cell movement, gap junctional intracellular coupling analysis, antimicrobial activity assay, red blood cell hemolysis test...
October 5, 2016: Journal of Gene Medicine
Deon V Canyon, Frederick M Burkle
Outcomes of the World Humanitarian Summit were mixed with some refreshing new directions being endorsed and a lack of systemic reform. The selective agenda and OCHAs lack of success in engaging pre-meeting political participation not only hampered the Summit's ability to deal with global issues and institutional reform, but also alienated it from leading aid agencies and governments. The UN's failure to commit to humanitarian principles and global disarray of the humanitarian system indicates the need for extensive reform or a new global humanitarian body...
August 30, 2016: PLoS Currents
Dariusz Dudek, Tomasz Rakowski, Adam Sukiennik, Michał Hawranek, Artur Dziewierz, Jacek Kubica, Piotr Suwalski, Robert Gil, Wojciech Wojakowski, Andrzej Ochała, Wiesław Mazurek, Krzysztof Żmudka, Mariusz Gąsior
No abstract text is available yet for this article.
2016: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
Benedikte Bjerge, Nathan Clark, Peter Fisker, Emmanuel Raju
This paper seeks to examine the extent to which technological advances can enhance inter-organizational information sharing in disaster relief. Our case is the Virtual OSOCC (On-Site Operations Coordination Centre) which is a part of the Global Disaster Alert and Coordination System (GDACS) under the United Nations Office for Coordination of Humanitarian Affairs (UN OCHA). The online platform, which has been developing for more than a decade, provides a unique insight into coordination behaviour among disaster management agencies and individual actors...
2016: PloS One
Waleed Al-Salem, Jennifer R Herricks, Peter J Hotez
BACKGROUND: Visceral leishmaniasis (VL), caused predominantly by Leishmania donovani and transmitted by both Phlebotomus orientalis and Phlebotomus martini, is highly endemic in East Africa where approximately 30 thousands VL cases are reported annually. The largest numbers of cases are found in Sudan - where Phlebotomus orientalis proliferate in Acacia forests especially on Sudan's eastern border with Ethiopia, followed by South Sudan, Ethiopia, Somalia, Kenya and Uganda. Long-standing civil war and unrest is a dominant determinant of VL in East African countries...
2016: Parasites & Vectors
Peiqin Li, Zhimin Cao, Zhou Wu, Xing Wang, Xiuhong Li
In this report, the effects of two oligochitosans, i.e., oligochitosan A (OCHA) and oligochitosan B (OCHB), on control of dry rot of Zanthoxylum bungeanum (Z. bungeanum) caused by Fusarium sambucinum (F. sambucinum) were evaluated. First, both oligochitosans show desirable ability to decrease the infection of F. sambucinum. Second, the oligochitosans strongly inhibit the radial colony and submerged biomass growth of F. sambucinum. Lastly, these oligochitosans are capable of increasing the activities of phenylalanine ammonia lyase (PAL), polyphenoloxidase (PPO) and peroxidase (POD) significantly, as well as enhancing the content of total phenolics in Z...
2016: International Journal of Molecular Sciences
Tomasz Roleder, Elżbieta Pociask, Wojciech Wańha, Magdalena Dobrolińska, Paweł Gąsior, Grzegorz Smolka, Wojciech Walkowicz, Tomasz Jadczyk, Tomasz Bochenek, Dariusz Dudek, Andrzej Ochała, Katarzyna Mizia-Stec, Zbigniew Gąsior, Michał Tendera, Ziad A Ali, Wojciech Wojakowski
BACKGROUND: The OCTOPUS registry prospectively evaluates the procedural and long-term outcomes of saphenous vein graft (SVG) PCI. The current study assessed the morphology of de novo lesions and in-stent restenosis (ISR) in patients undergoing PCI of SVG. METHODS AND RESULTS: Optical coherence tomography (OCT) of SVG lesions in consecutive patients presenting with stable CAD and ACS was carried out. Thirty-nine patients (32 de novo and 10 ISR lesions) were included in the registry...
July 25, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
Grzegorz Smolka, Piotr Pysz, Michał Kozłowski, Marek Jasiński, Radosław Gocoł, Tomasz Roleder, Agnieszka Kargul, Andrzej Ochała, Wojciech Wojakowski
INTRODUCTION: Transcatheter paravalvular leak closure (TPVLC) has become an established treatment option but is mostly performed with off-label use of different non-dedicated occluders. The first one specifically designed for TPVLC is the paravalvular leak device (PLD - Occlutech). AIM: We present initial short-term results of a prospective registry intended to assess the safety and efficacy of TPVLC with PLD. MATERIAL AND METHODS: We screened patients with paravalvular leak (PVL) after surgical valve replacement (SVR)...
2016: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
Łukasz Rzeszutko, Zbigniew Siudak, Tomasz Tokarek, Krzysztof Plens, Adrian Włodarczak, Andrzej Lekston, Andrzej Ochała, Robert J Gil, Wojciech Balak, Dariusz Dudek
INTRODUCTION: There are limited data describing bioresorbable vascular scaffold (BVS) implantation in complex lesions. Only short-term clinical outcomes are available for patients with acute coronary syndrome (ACS). AIM: To evaluate 12-month clinical outcome, safety and effectiveness of BVS implantation in complex lesions and in stable angina (SA) or ACS. MATERIAL AND METHODS: Five hundred ninety-one patients with SA/ACS were enrolled between October 2012 and November 2013 in 30 invasive cardiology centres in Poland...
2016: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
Mariusz Skowerski, Tomasz Roleder, Katarzyna Bańska-Kisiel, Piotr Pysz, Andrzej Ochała, Wojciech Wojakowski, Zbigniew Gąsior
UNLABELLED: The aim of this single-center study was to asses the long-term clinical data of patients with resistant hypertension who underwent radiofrequency renal denervation (RND). METHODS: Out of 86 patients with resistant-hypertension, 15 pts fulfilled the study criteria for performing RND using Simplicity system by Medtronic. RESULTS: Baseline office systolic BP was 204±32.7 and diastolic BP 107.7±15.1mmHg. Baseline 24h ambulatory systolic BP was 151...
July 15, 2016: International Journal of Cardiology
Damian Kawecki, Beata Morawiec, Janusz Dola, Wojciech Waha, Grzegorz Smolka, Aleksandra Pluta, Kamil Marcinkiewicz, Andrzej Ochała, Ewa Nowalany-Kozielska, Wojciech Wojakowski
BACKGROUND: There are sparse data on the performance of different types of drug-eluting stents (DES) in acute and real-life setting. OBJECTIVE: The aim of the study was to compare the safety and efficacy of first- versus second-generation DES in patients with acute coronary syndromes (ACS). METHODS: This all-comer registry enrolled consecutive patients diagnosed with ACS and treated with percutaneous coronary intervention with the implantation of first- or second-generation DES in one-year follow-up...
May 2016: Arquivos Brasileiros de Cardiologia
Tomasz Roleder, Mariusz Skowerski, Andrzej Wiecek, Marcin Adamczak, Beata Czerwienska, Wojciech Wanha, Tomasz Jadczyk, Lukasz Partyka, Grzegorz Smolka, Wacław Kuczmik, Andrzej Ochała, Dariusz Dudek, Michał Tendera, Zbigniew Gasior, Wojciech Wojakowski
Optical coherence tomography (OCT) imaging at the time of renal denervation (RDN) showed that procedure might cause spasm, intimal injury or thrombus formation. In the present study, we assessed the healing of renal arteries after RDN using OCT and renal angiography in long-term follow-up. OCT and renal angiography were performed in 12 patients (22 arteries) 18.41 ± 5.83 months after RNS. There were no adverse events or complications during the long-term follow-up. In ten patients (83 %), significant reductions of blood pressure was achieved without a change of the antihypertensive medications...
June 2016: International Journal of Cardiovascular Imaging
Justyna Chalubinska-Fendler, Agnieszka Butwicka, Patrycja Kaźmierczak, Anna Jałocha-Kaczka, Wojciech Fendler, Jacek Fijuth
No abstract text is available yet for this article.
December 10, 2015: Archives of Medical Science: AMS
Paweł Nadrowski, Marcin Syzdół, Wojciech Wańha, Edyta Nabiałek, Michał Skrzypek, Joanna Góral, Maria Siewniak, Krystyna Kozakiewicz, Andrzej Ochała, Michał Tendera, Wojciech Wojakowski
BACKGROUND: Clinical studies have suggested increased risk of thrombotic events after planned cessation of clopidogrel therapy, due to increased platelet reactivity (platelet rebound); however, in many studies platelet function was not assessed before introducing clopidogrel. Patients who are scheduled to stop clopidogrel therapy, do it abruptly, so a gradual drug cessation might provide a beneficial treatment strategy. AIM: To determine whether a clopidogrel discontinuation results in platelet rebound hyperaggregability with increased activity compared to pre-treatment values and to assess whether abrupt or tapering clopidogrel cessation may affect platelet reactivity...
2016: Kardiologia Polska
Tomasz Roleder, Wojciech Wanha, Grzegorz Smolka, Jacek Zimoch, Andrzej Ochała, Wojciech Wojakowski
No abstract text is available yet for this article.
2015: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
Andrzej Ochała, Zbigniew Siudak, Jacek Legutko, Radosław Parma, Zbigniew Chmielak, Stanisław Bartuś, Sławomir Dobrzycki, Marek Grygier, Tomasz Moszura, Tomasz Pawłowski, Dariusz Dudek
INTRODUCTION: The Board of the Association of Cardiovascular Interventions of the Polish Cardiac Society (AISN PTK) publishes annual data from the National PCI Registry (ORPKI) operated by the Jagiellonian University Medical College in Krakow. AIM: For the first time the AISN PTK report is based on the new electronic database implemented in Poland on January 1(st), 2014. MATERIAL AND METHODS: In 2014, there were 155 invasive cardiology centers registered in the ORPKI database (an increase by 1 center in comparison to 2013) and 92% of them had 24/7 percutaneous (PCI) duty...
2015: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
Wojciech Wańha, Damian Kawecki, Tomasz Roleder, Aleksandra Pluta, Kamil Marcinkiewicz, Janusz Dola, Beata Morawiec, Łukasz Krzych, Tomasz Pawłowski, Grzegorz Smolka, Andrzej Ochała, Ewa Nowalany-Kozielska, Michał Tendera, Wojciech Wojakowski
BACKGROUND: Coexisting anaemia is associated with an increased risk of major adverse cardiac and cerebrovascular events (MACCE) and bleeding complications after percutaneous coronary intervention (PCI), especially in patients with acute coronary syndrome. AIM: To assess the impact of anaemia in patients with coronary artery disease (CAD) treated with first- and second-generation drug-eluting stents (DES) on one-year MACCE. METHODS AND RESULTS: The registry included 1916 consecutive patients (UA: n = 1502, 78...
2016: Kardiologia Polska
Damian Kawecki, Beata Morawiec, Janusz Dola, Wojciech Wańha, Grzegorz Smolka, Aleksandra Pluta, Kamil Marcinkiewicz, Andrzej Ochała, Ewa Nowalany-Kozielska, Wojciech Wojakowski
BACKGROUND: This study compared safety and efficacy of first- and second-generation DES in an unrestricted, real-life population of diabetic patients undergoing PCI. MATERIAL AND METHODS: The study was a subanalysis of diabetic patients from the all-comer Katowice-Zabrze Registry of patients undergoing PCI with the implantation of either first- (Paclitaxel-, Sirolimus-eluting stents) or second-generation DES (Zotarolimus-, Everolimus-, Biolimus-eluting stents). Efficacy defined as major adverse cardiac and cerebrovascular events (MACCE: death, myocardial infarction, target vessel revascularization, stroke) and safety defined as stent thrombosis (ST) were evaluated at 1 year...
2015: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Tomasz Roleder, Grzegorz Smolka, Ewa Podolecka, Jolanta Chudek, Sebastian Dworowy, Katarzyna Żelazowska, Wojciech Wojakowski, Andrzej Ochała
BACKGROUND: Data from clinical trials suggested that biodegradable-polymer-based drug-eluting stents (DES) might improve long-term clinical outcomes. PROLIM (Balton, Warsaw, Poland) DES is based on a stainless steel platform with a closed cell design releasing sirolimus from biodegradable copolymer (lactic and glycolic acid) in eight weeks. AIM: In the present study the safety and the efficacy of a PROLIM stent was assessed in patients with de novo coronary lesions in 12-month clinical follow-up...
2016: Kardiologia Polska
Aneta Doricakova, Radim Vrzal
Ochratoxin A (OCHA) is a mycotoxin, which can be found in food such as coffee, wine, cereals, meat, nuts. Since it is absorbed via gastrointestinal tract, it is reasonable to anticipate that the liver will be the first organ to which OCHA comes into the contact before systemic circulation. Many xenobiotics are metabolically modified after the passage of the liver to biologically more active substances, sometimes with more harmful activity. Promoting own metabolism is often achieved via transcriptional regulation of biotransformation enzymes through ligand-activated transcription factors...
November 4, 2015: Toxicology
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