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https://www.readbyqxmd.com/read/29145707/relationship-between-testosterone-in-serum-saliva-and-urine-during-treatment-with-intramuscular-testosterone-undecanoate-in-gender-dysphoria-and-male-hypogonadism
#1
Y Lood, E Aardal-Eriksson, C Webe, J Ahlner, B Ekman, J Wahlberg
Long-term testosterone replacement therapy is mainly monitored by trough levels of serum testosterone (S-T), while urinary testosterone (U-T) is used by forensic toxicology to evaluate testosterone doping. Testosterone in saliva (Sal-T) may provide additional information and simplify the sample collection. We aimed to investigate the relationships between testosterone measured in saliva, serum and urine during standard treatment with 1,000 mg testosterone undecanoate (TU) every 12th week during 1 year. This was an observational study...
November 16, 2017: Andrology
https://www.readbyqxmd.com/read/29120922/gender-dysphoria-in-youth-a-review-of-recent-literature
#2
Julia Cartaya, Ximena Lopez
PURPOSE OF REVIEW: Transgender individuals including pubertal young people require hormonal therapy, in conjunction with mental health support. These youths are a unique population, with specific and individual desires and needs as they move through the physical and mental transition to the gender with which they identify. RECENT FINDINGS: The number of transgender youth presenting for treatment is increasing rapidly. They continue to have a high prevalence of mental health disorders, though not when supported in their sex identities by family in younger age...
November 7, 2017: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/29110095/gender-dysphoria-in-the-military
#3
REVIEW
Shannon Ford, Carla Schnitzlein
PURPOSE OF REVIEW: With the announcement that members of the military who identify as transgender are allowed to serve openly, the need for Department of Defense behavioral health providers to be comfortable in the assessment, diagnosis, and treatment of this population becomes quickly evident. This population has been seeking care in the community and standards have been developed to help guide decision-making, but a comparable document does not exist for the military population. RECENT FINDINGS: Previously published papers were written in anticipation of the policy allowing for open service...
November 7, 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/29108153/gender-dysphoria-in-children
#4
(no author information available yet)
Gender dysphoria (GD) of childhood describes a psychological condition in which children experience a marked incongruence between their experienced gender and the gender associated with their biological sex. When this occurs in the pre-pubertal child, GD resolves in the vast majority of patients by late adolescence. Currently there is a vigorous, albeit suppressed, debate among physicians, therapists, and academics regarding what is fast becoming the new treatment standard for GD in children. This new paradigm is rooted in the assumption that GD is innate, and involves pubertal suppression with gonadotropin releasing hormone (GnRH) agonists followed by the use of cross-sex hormones-a combination that results in the sterility of minors...
2017: Issues in Law & Medicine
https://www.readbyqxmd.com/read/29101439/male-to-female-sex-reassignment-surgery-using-the-combined-vaginoplasty-technique-satisfaction-of-transgender-patients-with-aesthetic-functional-and-sexual-outcomes
#5
Dmitry Zavlin, Jürgen Schaff, Jean-Daniel Lellé, Kevin T Jubbal, Peter Herschbach, Gerhard Henrich, Benjamin Ehrenberger, Laszlo Kovacs, Hans-Günther Machens, Nikolaos A Papadopulos
BACKGROUND: Currently available patient-reported outcome measures are limited in the field of sex reassignment surgery (SRS). Standardized questionnaires deliver high evidence data on satisfaction of male-to-female (MTF) transgender patients but do not allow any modification in their clinical application. We therefore designed a prospective study using self-developed indication-specific questionnaires to evaluate the aesthetic, functional, and sexual outcomes of MTF patients undergoing SRS...
November 3, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29057562/complications-of-the-neovagina-in-male-to-female-transgender-surgery-a-systematic-review-and-meta-analysis-with-discussion-of-management
#6
REVIEW
Paulette Cutruzzula Dreher, Daniel Edwards, Shaun Hager, Margeaux Dennis, Andie Belkoff, Jamie Mora, Susan Tarry, Kathy L Rumer
Introduction Gender-affirmation surgery is often the final gender-confirming medical intervention sought by those patients suffering from gender dysphoria. In the male-to-female transgendered patient, the creation of aesthetic and functional external female genitalia with a functional vaginal channel is of the utmost importance. The aim of this review and meta-analysis is to evaluate the epidemiology, presentation, management and outcomes of neovaginal complications in the male-to-female transgender reassignment surgery patients...
October 23, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/29056436/physiologic-response-to-gender-affirming-hormones-among-transgender-youth
#7
Johanna Olson-Kennedy, Vivian Okonta, Leslie F Clark, Marvin Belzer
PURPOSE: The purpose of this study was to examine the physiologic impact of hormones on youth with gender dysphoria. These data represent follow-up data in youth ages 12-23 years over a two-year time period of hormone administration. METHODS: This prospective, longitudinal study initially enrolled 101 youth with gender dysphoria at baseline from those presenting consecutively for care between February 2011 and June 2013. Physiologic data at baseline and follow-up were abstracted from medical charts...
October 19, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29050504/transgender-research-in-the-21st-century-a-selective-critical-review-from-a-neurocognitive-perspective
#8
Sven C Mueller, Griet De Cuypere, Guy T'Sjoen
Gender dysphoria describes the psychological distress caused by identifying with the sex opposite to the one assigned at birth. In recent years, much progress has been made in characterizing the needs of transgender persons wishing to transition to their preferred gender, thus helping to optimize care. This critical review of the literature examines their common mental health issues, several individual risk factors for psychiatric comorbidity, and current research on the underlying neurobiology. Prevalence rates of persons identifying as transgender and seeking help with transition have been rising steeply since 2000 across Western countries; the current U...
October 20, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29021824/intense-obsessional-interests-in-children-with-gender-dysphoria-a-cross-validation-study-using-the-teacher-s-report-form
#9
Kenneth J Zucker, A Natisha Nabbijohn, Alanna Santarossa, Hayley Wood, Susan J Bradley, Joanna Matthews, Doug P VanderLaan
OBJECTIVE: This study assessed whether children clinically referred for gender dysphoria (GD) show symptoms that overlap with Autism Spectrum Disorder (ASD). Circumscribed preoccupations/intense interests and repetitive behaviors were considered as overlapping symptoms expressed in both GD and ASD. METHODS: To assess these constructs, we examined Items 9 and 66 on the Teacher's Report Form (TRF), which measure obsessions and compulsions, respectively. RESULTS: For Item 9, gender-referred children (n = 386) were significantly elevated compared to the referred (n = 965) and non-referred children (n = 965) from the TRF standardization sample...
2017: Child and Adolescent Psychiatry and Mental Health
https://www.readbyqxmd.com/read/28972892/brain-functional-connectivity-patterns-in-children-and-adolescents-with-gender-dysphoria-sex-atypical-or-not
#10
Nienke M Nota, Baudewijntje P C Kreukels, Martin den Heijer, Dick J Veltman, Peggy T Cohen-Kettenis, Sarah M Burke, Julie Bakker
Various previous studies have reported that brains of people diagnosed with gender dysphoria (GD) show sex-atypical features. In addition, recent functional magnetic resonance imaging studies found that several brain resting-state networks (RSNs) in adults with GD show functional connectivity (FC) patterns that are not sex-atypical, but specific for GD. In the current study we examined whether FC patterns are also altered in prepubertal children and adolescents with GD in comparison with non-gender dysphoric peers...
December 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28964001/-is-sexual-identity-optional-a-study-of-the-genetics-of-transsexuality
#11
Rosa M Fernández García, Eduardo Pásaro Méndez
Transsexualism in the ICD-10 (International Classification of Diseases, Tenth Revision), Gender Dysphoria in adolescents and adults in the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition), is characterized by a marked incongruence between one's experienced gender and biological sex. The etiology is complex, but some hypotheses suggest that Gender Dysphoria (GD) arises from discrepant cerebral and biological sexual differentiation. Increasing evidence supports the idea of genetic vulnerability...
September 2017: Cuadernos de Bioética: Revista Oficial de la Asociación Española de Bioética y Ética Médica
https://www.readbyqxmd.com/read/28945902/endocrine-treatment-of-gender-dysphoric-gender-incongruent-persons-an-endocrine-society-clinical-practice-guideline
#12
Wylie C Hembree, Peggy T Cohen-Kettenis, Louis Gooren, Sabine E Hannema, Walter J Meyer, M Hassan Murad, Stephen M Rosenthal, Joshua D Safer, Vin Tangpricha, Guy G T'Sjoen
Objective: To update the "Endocrine Treatment of Transsexual Persons: An Endocrine Society Clinical Practice Guideline," published by the Endocrine Society in 2009. Participants: The participants include an Endocrine Society-appointed task force of nine experts, a methodologist, and a medical writer. Evidence: This evidence-based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation approach to describe the strength of recommendations and the quality of evidence...
November 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28944319/the-ethics-of-fertility-preservation-for-pediatric-patients-with-differences-disorders-of-sex-development
#13
Lisa Campo-Engelstein, Diane Chen, Arlene B Baratz, Emilie K Johnson, Courtney Finlayson
Differences (disorders) of sex development are diverse conditions with variations in chromosomal, gonadal, and/or genital development. Fertility potential in this population is variable. Recent investigations into fertility potential in those previously thought to be infertile suggest that the majority may have fertility potential through experimental protocols. Fertility preservation may be more successful if pursued in childhood. As fertility research and techniques advance, it is important to carefully consider pediatric ethical issues specific to this population, including gonadectomy, consent/assent, experimental treatment and false hope, cost and insurance coverage, genetic transmission to offspring, and gender dysphoria...
June 1, 2017: J Endocr Soc
https://www.readbyqxmd.com/read/28943352/genital-reconstruction-for-the-transgendered-individual
#14
REVIEW
Marta R Bizic, Borko Stojanovic, Miroslav L Djordjevic
INTRODUCTION: Gender dysphoria is defined as one's belief that his/her body does not reflect his/her true "inner" identification of physical sex and requires medical and/or surgical treatment that will alter his/her body to better reflect what he/she believes is his/her true gender. OBJECTIVE: The aim was to describe current surgical techniques available in genital reconstruction for female-to-male (FTM) and male-to-female (MTF) transgender patients. STUDY DESIGN: We reviewed recently published papers concerning the most common procedures in genital reconstruction in FTM transgenders and in MTF transgenders...
October 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28940910/the-outcomes-of-inflatable-penile-prosthesis-insertion-in-247-patients-completing-female-to-male-gender-reassignment-surgery
#15
M Falcone, G Garaffa, A Gillo, D Dente, A N Christopher, D J Ralph
OBJECTIVES: To assess the oucomes of penile prosthesis (PP) implantation after total phallic reconstruction secondary to gender dysphoria (GD). SUBJECT/PATIENTS AND METHODS: We conducted a retrospective single center analysis of 247 consecutive patients. The recruitment time was between January 2001 and October 2015. A total of 328 inflatable PP were implanted. A two-staged inflatable PP implantation was carried out. As a first step, an extraperitoneal reservoir placement was performed simultaneously with the glans sculpture and the insertion of a single large testicular prosthesis into the labia majora...
September 23, 2017: BJU International
https://www.readbyqxmd.com/read/28914501/andrology-of-male-to-female-transsexuals-influence-of-cross-sex-hormone-therapy-on-testicular-function
#16
REVIEW
F Schneider, S Kliesch, S Schlatt, N Neuhaus
Patients with gender dysphoria are offered cross-sex hormone therapy and sex reassignment surgery to achieve the transition between the sex assigned at birth and gender identity. According to international guidelines, cross-sex hormone therapy in trans-women should lead to a psychologically and physiologically healthy body with feminized serum hormone levels, resulting in suppression of spermatogenesis. However, in a recently published multi-center study, we discovered a high proportion of patients with male serum hormone levels and qualitatively intact spermatogenesis on the day of sex reassignment surgery...
September 2017: Andrology
https://www.readbyqxmd.com/read/28914080/gender-identity-and-sexual-orientation-in-autism-spectrum-disorder
#17
Rita George, Mark A Stokes
Clinical impressions indicate that there is an overrepresentation of gender-dysphoria within the autism spectrum disorder. However, little is presently known about the demographics of gender-identity issues in autism spectrum disorder. Based upon what little is known, we hypothesized that there would be an increased prevalence of gender-dysphoria among those with autism spectrum disorder compared to a typically developing population. We surveyed gender-dysphoria with the Gender-Identity/Gender-Dysphoria Questionnaire among 90 males and 219 females with autism spectrum disorder and compared these rates to those of 103 males and 158 females without autism spectrum disorder...
September 1, 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/28894664/aesthetic-female-to-male-chest-transformation-power-of-combining-modified-mastectomy-with-a-pectoral-implant
#18
Turkia Abbed, David A Shifrin
Gender reassignment surgery has gained in popularity with increased media exposure and society's recognition of gender dysphoria. Female-to-male gender reassignment often begins with the "top" or chest surgery. Mastectomy with free nipple grafting is the most frequently described technique in the literature. This technique is reliable yet lacks the ability to provide a true male chest shape. We discuss our technique for female-to-male "top" surgery combining traditional mastectomy techniques with a lower pole pedicle vascularized areola and a pectoral implant...
August 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28861549/overrepresentation-of-adopted-adolescents-at-a-hospital-based-gender-dysphoria-clinic
#19
Daniel E Shumer, Aser Abrha, Henry A Feldman, Jeremi Carswell
Purpose: We have noted a greater than expected prevalence of adopted children presenting to our multidisciplinary gender program for evaluation of gender dysphoria. Methods: A retrospective review of 184 patient charts was conducted to assess the prevalence of adopted children presenting to gender clinic. Results: Fifteen of 184 patients seen were living with adoptive families (8.2%). This is significantly higher than expected based on U.S. census data. Conclusion: Adopted children are referred to our gender program more than would be expected based on the percentage of adopted children in our state and the United States at large...
2017: Transgender Health
https://www.readbyqxmd.com/read/28858881/online-patient-resources-for-gender-affirmation-surgery-an-analysis-of-readability
#20
Elizabeth Kiwanuka, Raman Mehrzad, Adnan Prsic, Daniel Kwan
BACKGROUND: Gender affirmation surgery is an important treatment for patient with gender dysphoria. It consists of a series of complex procedures, and well-informed patients have been shown to have better outcomes. However, there are no published data regarding the readability of currently available online patient recourses for gender affirmation surgery. This study aims at identifying the most popular online resources and evaluating the readability of these documents in the context of average literacy within the United States...
October 2017: Annals of Plastic Surgery
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