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https://www.readbyqxmd.com/read/28108358/neurochemical-and-metabolic-effects-of-acute-and-chronic-alcohol-in-the-human-brain-studies-with-positron-emission-tomography
#1
REVIEW
Nora D Volkow, Corinde E Wiers, Ehsan Shokri-Kojori, Dardo Tomasi, Gene-Jack Wang, Ruben Baler
The use of Positron emission tomography (PET) to study the effects of acute and chronic alcohol on the human brain has enhanced our understanding of the mechanisms underlying alcohol's rewarding effects, the neuroadaptations from chronic exposure that contribute to tolerance and withdrawal, and the changes in fronto-striatal circuits that lead to loss of control and enhanced motivation to drink that characterize alcohol use disorders (AUD). These include studies showing that alcohol's reinforcing effects may result not only from its enhancement of dopaminergic, GABAergic and opioid signaling but also from its caloric properties...
January 17, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28108189/the-longitudinal-impact-of-an-internet-safety-decision-aid-for-abused-women
#2
Nancy E Glass, Nancy A Perrin, Ginger C Hanson, Tina L Bloom, Jill T Messing, Amber S Clough, Jacquelyn C Campbell, Andrea C Gielen, James Case, Karen B Eden
INTRODUCTION: Women experiencing intimate partner violence (IPV) navigate complex, dangerous decisions. Tailored safety information and safety planning, typically provided by domestic violence service providers, can prevent repeat IPV exposure and associated adverse health outcomes; however, few abused women access these services. The Internet represents a potentially innovative way to connect abused women with tailored safety planning resources and information. The purpose of this study was to compare safety and mental health outcomes at baseline, 6 months, and 12 months among abused women randomized to: (1) a tailored, Internet-based safety decision aid; or (2) control website (typical safety information available online)...
January 17, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28107041/sleep-and-optimism-a-longitudinal-study-of-bidirectional-causal-relationship-and-its-mediating-and-moderating-variables-in-a-chinese-student-sample
#3
Esther Yuet Ying Lau, C Harry Hui, Jasmine Lam, Shu-Fai Cheung
While both sleep and optimism have been found to be predictive of well-being, few studies have examined their relationship with each other. Neither do we know much about the mediators and moderators of the relationship. This study investigated (1) the causal relationship between sleep quality and optimism in a college student sample, (2) the role of symptoms of depression, anxiety, and stress as mediators, and (3) how circadian preference might moderate the relationship. Internet survey data were collected from 1,684 full-time university students (67...
January 20, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28104051/relation-between-emotional-intelligence-socio-demographic-and-clinical-characteristics-of-patients-with-depressive-disorders
#4
Sayeda Ahmed Abdellatif, El-Sayed Saleh Hussien, Warda Elshahat Hamed, Mohamed Ali Zoromba
The present study aims to assess the emotional intelligence in relation to socio-demographic and clinical characteristics of patients with depressive disorders. A descriptive correlational study was utilized with a sample of (106) depressed patients who were diagnosed by a psychiatrist with depressive disorders at psychiatric outpatient clinics in Mansoura University Hospital. Data were collected through assessing socio demographic and clinical characteristics, assessing level of depression using Beck Depression Inventory BDI-II, and assessing emotional intelligence using Barchard emotional intelligence scales...
February 2017: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/28098747/integrated-treatment-of-ptsd-and-substance-use-disorders-the-mediating-role-of-ptsd-improvement-in-the-reduction-of-depression
#5
Kristina J Korte, Kaitlin E Bountress, Rachel L Tomko, Therese Killeen, Megan Moran-Santa Maria, Sudie E Back
Posttraumatic stress disorder (PTSD) represents one of the most common mental health disorders, particularly among veterans, and is associated with significant distress and impairment. This highly debilitating disorder is further complicated by common comorbid psychiatric disorders, such as substance use disorders (SUD). Individuals with PTSD and co-occurring SUD also commonly present with secondary symptoms, such as elevated depression. Little is known, however, about how these secondary symptoms are related to treatment outcome...
January 13, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28097648/a-systematic-review-and-meta-analysis-of-prospective-transition-from-major-depression-to-bipolar-disorder
#6
A Ratheesh, C Davey, S Hetrick, M Alvarez-Jimenez, C Voutier, A Bechdolf, P D McGorry, J Scott, M Berk, S M Cotton
OBJECTIVE: Some people with major depressive disorder (MDD) may be at a pre-onset stage for bipolar disorder (BD), where early identification or prevention efforts may be feasible. We aimed to identify rates and characteristics predictive of transition to BD in prospective follow-up studies of people with MDD. METHODS: Using a systematic search strategy, we identified studies with a diagnostic ascertainment of MDD and BD of an adequate standard, and where the minimum length of follow-up was 6 months...
January 18, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28075650/pharmacokinetic-evaluation-of-pregabalin-for-the-treatment-of-generalized-anxiety-disorder
#7
Massimiliano Buoli, Alice Caldiroli, Marta Serati
Pregabalin is an alternative compound to SSRIs and SNRIs for the first-line treatment of generalized anxiety disorder (GAD). Areas covered: We describe the pharmacokinetic properties of pregabalin and their implications for the treatment of GAD. A search in the main database sources (Medline, ISI, Web of Knowledge and Medscape) was performed in order to obtain a comprehensive and balanced evaluation about the clinical implications of the pharmacokinetic properties of pregabalin in the treatment of GAD. The word "pregabalin" was associated with "pharmacokinetics", "interactions"', "GAD", "anxiety" and "tolerability"...
January 11, 2017: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/28069664/physical-activity-sedentary-behavior-and-symptoms-of-major-depression-in-middle-childhood
#8
Tonje Zahl, Silje Steinsbekk, Lars Wichstrøm
OBJECTIVE: The prospective relation between physical activity and Diagnostic and Statistical Manual of Mental Disorders-defined major depression in middle childhood is unknown, as is the stability of depression. We therefore aimed to (1) determine whether there are reciprocal relations between moderate-to-vigorous physical activity (MVPA) and sedentary behavior, on one hand, and Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition defined symptoms of major depressive disorder, on the other and (2) assess the extent of stability in depressive symptoms from age 6 to 10 years...
January 9, 2017: Pediatrics
https://www.readbyqxmd.com/read/28069609/short-web-based-guided-self-help-intervention-prevents-the-onset-of-a-major-depressive-disorder-in-adults-with-subthreshold-depression
#9
Linda Bolier, Brigitte Boon
No abstract text is available yet for this article.
January 9, 2017: Evidence-based Mental Health
https://www.readbyqxmd.com/read/28069457/quercetin-prevents-chronic-unpredictable-stress-induced-behavioral-dysfunction-in-mice-by-alleviating-hippocampal-oxidative-and-inflammatory-stress
#10
Vineet Mehta, Arun Parashar, Malairaman Udayabanu
It is now evident that chronic stress is associated with anxiety, depression and cognitive dysfunction and very few studies have focused on identifying possible methods to prevent these stress-induced disorders. Previously, we identified abundance of quercetin in Urtica dioica extract, which efficiently attenuated stress related complications. Therefore, current study was designed to investigate the effect of quercetin on chronic unpredicted stress (CUS) induced behavioral dysfunction, oxidative stress and neuroinflammation in the mouse hippocampus...
January 7, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28068285/vitamin-k2-improves-anxiety-and-depression-but-not-cognition-in-rats-with-metabolic-syndrome-a-role-of-blood-glucose
#11
Silvia M Gancheva, Maria D Zhelyazkova-Savova
BACKGROUND: The metabolic syndrome is a socially important disorder of energy utilization and storage, recognized as a factor predisposing to the development of depression, anxiety and cognitive impairment in humans. AIM: In the present study we examined the effects of vitamin K2 on the behavior of rats with metabolic syndrome and looked for relationships with the effects on blood sugar. MATERIALS AND METHODS: Male Wistar rats were divided in four groups: a control group on a regular rat chow, a metabolic syndrome (MS) group fed a high-fat high-fructose diet, a control group treated with vitamin K2 and a MS group treated with vitamin K2...
December 1, 2016: Folia Medica
https://www.readbyqxmd.com/read/28067785/relationships-between-gat1-and-ptsd-depression-and-substance-use-disorder
#12
Kaitlin E Bountress, Wei Wei, Christina Sheerin, Dongjun Chung, Ananda B Amstadter, Howard Mandel, Zhewu Wang
Post-traumatic stress disorder (PTSD), Major Depressive Disorder (MDD), and Substance Use Disorder (SUD) have large public health impacts. Therefore, researchers have attempted to identify those at greatest risk for these phenotypes. PTSD, MDD, and SUD are in part genetically influenced. Additionally, genes in the glutamate and gamma-aminobutyric acid (GABA) system are implicated in the encoding of emotional and fear memories, and thus may impact these phenotypes. The current study examined the associations of single nucleotide polymorphisms in GAT1 individually, and at the gene level, using a principal components (PC) approach, with PTSD, PTSD comorbid with MDD, and PTSD comorbid with SUD in 486 combat-exposed veterans...
January 5, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28066008/revisiting-profile-of-deliberate-self-harm-at-a-tertiary-care-hospital-after-an-interval-of-10-years
#13
Paramjeet Singh, Raghav Shah, Purav Midha, Ajitabh Soni, Sunil Bagotia, Kusum Lata Gaur
CONTEXT: Sociocultural factors complement psychopathological factors that result in deliberate self-harm (DSH). A study of change in these factors over time is essential for preventive action. AIMS: To identify factors influencing DSH, which have shown significant variation over a period of 10 years. SETTINGS AND DESIGN: Two hospital-based cross-sectional analytic types of observational studies were performed at two different times at an interval of 10 years...
July 2016: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28065900/exploring-the-predictive-power-of-polygenic-scores-derived-from-genome-wide-association-studies-a-study-of-10-complex-traits
#14
Hon-Cheong So, Pak C Sham
MOTIVATION: It is hoped that advances in our knowledge in disease genomics will contribute to personalized medicine such as individualized preventive strategies or early diagnoses of diseases. With the growth of genome-wide association studies (GWAS) in the past decade, how far have we reached this goal? In this study we explored the predictive ability of polygenic risk scores (PRSs) derived from GWAS for a range of complex disease and traits. RESULTS: We first proposed a new approach to evaluate predictive performances of PRS at arbitrary P-value thresholds...
January 8, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28065208/mental-health-and-psychosocial-problems-in-the-aftermath-of-the-nepal-earthquakes-findings-from-a-representative-cluster-sample-survey
#15
J C Kane, N P Luitel, M J D Jordans, B A Kohrt, I Weissbecker, W A Tol
AIMS: Two large earthquakes in 2015 caused widespread destruction in Nepal. This study aimed to examine frequency of common mental health and psychosocial problems and their correlates following the earthquakes. METHODS: A stratified multi-stage cluster sampling design was employed to randomly select 513 participants (aged 16 and above) from three earthquake-affected districts in Nepal: Kathmandu, Gorkha and Sindhupalchowk, 4 months after the second earthquake. Outcomes were selected based on qualitative preparatory research and included symptoms of depression and anxiety (Hopkins Symptom Checklist-25); post-traumatic stress disorder (PTSD Checklist-Civilian); hazardous alcohol use (AUDIT-C); symptoms indicating severe psychological distress (WHO-UNHCR Assessment Schedule of Serious Symptoms in Humanitarian Settings (WASSS)); suicidal ideation (Composite International Diagnostic Interview); perceived needs (Humanitarian Emergency Settings Perceived Needs Scale (HESPER)); and functional impairment (locally developed scale)...
January 9, 2017: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/28062252/using-neuroimaging-to-individualize-tms-treatment-for-depression-toward-a-new-paradigm-for-imaging-guided-intervention
#16
Bruce M Luber, Simon Davis, Elisabeth Bernhardt, Andrada Neacsiu, Lori Kwapil, Sarah H Lisanby, Timothy J Strauman
The standard clinical technique for using repetitive transcranial magnetic stimulation (rTMS) for major depressive disorder (MDD) is associated with limited efficacy to date. Such limited efficacy may be due to reliance on scalp-based targeting rather than state-of-the-science methods which incorporate fMRI-guided neuronavigation based on a specific model of neurocircuit dysfunction. In this review, we examine such a specific model drawn from regulatory focus theory, which postulates two brain/behavior systems, the promotion and prevention systems, underlying goal pursuit...
January 3, 2017: NeuroImage
https://www.readbyqxmd.com/read/28061819/association-between-a-syndemic-of-psychosocial-problems-and-unprotected-anal-intercourse-among-men-who-have-sex-with-men-in-shanghai-china
#17
Ying Wang, Zezhou Wang, Mengmeng Jia, Ajuan Liang, Dong Yuan, Zhe Sun, Feng Gan, Yichen Wang, Yong Cai, Zhiruo Zhang
BACKGROUND: Previous studies have discussed the overlapping and reinforcing effects (defined as a syndemic) of psychosocial problems on high-risk sexual behaviors among men who have sex with men (MSM). The present study aimed to apply the syndemic theory to verify the reinforcing effects of psychosocial problems on unprotected anal intercourse (UAI) among MSM in Shanghai, and determine if other important psychosocial factors fit into the syndemic theory. METHODS: Data were collected from 547 MSM in Shanghai, China, through face-to-face interviews...
January 7, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28052841/preventing-depression-in-adults-with-subthreshold-depression-health-economic-evaluation-alongside-a-pragmatic-randomized-controlled-trial-of-a-web-based-intervention
#18
Claudia Buntrock, Matthias Berking, Filip Smit, Dirk Lehr, Stephanie Nobis, Heleen Riper, Pim Cuijpers, David Ebert
BACKGROUND: Psychological interventions for the prevention of depression might be a cost-effective way to reduce the burden associated with depressive disorders. OBJECTIVE: To evaluate the cost-effectiveness of a Web-based guided self-help intervention to prevent major depressive disorder (MDD) in people with subthreshold depression (sD). METHODS: A pragmatic randomized controlled trial was conducted with follow-up at 12 months. Participants were recruited from the general population via a large statutory health insurance company and an open access website...
January 4, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28049620/how-do-people-experiencing-schizophrenia-spectrum-disorders-or-other-psychotic-disorders-use-the-internet-to-get-information-on-their-mental-health-literature-review-and-recommendations
#19
Murielle Villani, Viviane Kovess-Masfety
BACKGROUND: Studies show that the Internet has become an influential source of information for people experiencing serious psychiatric conditions such as schizophrenia spectrum disorders or other psychotic disorders, among which the rate of Internet users is growing, with rates ranging from 33.3% to 79.5% given the country. Between 20.5% and 56.4% of these Internet users seek mental health information. OBJECTIVE: Focusing on this population's Web searches about their mental health, this paper examines what type of content they look for and what could be the benefits and disadvantages of this navigation...
January 3, 2017: JMIR Mental Health
https://www.readbyqxmd.com/read/28049069/prevention-of-anxiety-disorders-and-depression-by-targeting-excessive-worry-and-rumination-in-adolescents-and-young-adults-a-randomized-controlled-trial
#20
Maurice Topper, Paul M G Emmelkamp, Ed Watkins, Thomas Ehring
BACKGROUND: This randomized controlled trial evaluated the efficacy of a preventive intervention for anxiety disorders and depression by targeting excessive levels of repetitive negative thinking (RNT; worry and rumination) in adolescents and young adults. METHODS: Participants (N = 251, 83.7% female) showing elevated levels of RNT were randomly allocated to a 6-week cognitive-behavioral training delivered in a group, via the internet, or to a waitlist control condition...
December 23, 2016: Behaviour Research and Therapy
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