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depressive disorder prevention

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https://www.readbyqxmd.com/read/28075650/pharmacokinetic-evaluation-of-pregabalin-for-the-treatment-of-generalized-anxiety-disorder
#1
Massimiliano Buoli, Alice Caldiroli, Marta Serati
Pregabalin is an alternative compound to SSRIs and SNRIs for the first-line treatment of generalized anxiety disorder (GAD). Areas covered: We describe the pharmacokinetic properties of pregabalin and their implications for the treatment of GAD. A search in the main database sources (Medline, ISI, Web of Knowledge and Medscape) was performed in order to obtain a comprehensive and balanced evaluation about the clinical implications of the pharmacokinetic properties of pregabalin in the treatment of GAD. The word "pregabalin" was associated with "pharmacokinetics", "interactions"', "GAD", "anxiety" and "tolerability"...
January 11, 2017: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/28069664/physical-activity-sedentary-behavior-and-symptoms-of-major-depression-in-middle-childhood
#2
Tonje Zahl, Silje Steinsbekk, Lars Wichstrøm
OBJECTIVE: The prospective relation between physical activity and Diagnostic and Statistical Manual of Mental Disorders-defined major depression in middle childhood is unknown, as is the stability of depression. We therefore aimed to (1) determine whether there are reciprocal relations between moderate-to-vigorous physical activity (MVPA) and sedentary behavior, on one hand, and Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition defined symptoms of major depressive disorder, on the other and (2) assess the extent of stability in depressive symptoms from age 6 to 10 years...
January 9, 2017: Pediatrics
https://www.readbyqxmd.com/read/28069609/short-web-based-guided-self-help-intervention-prevents-the-onset-of-a-major-depressive-disorder-in-adults-with-subthreshold-depression
#3
Linda Bolier, Brigitte Boon
No abstract text is available yet for this article.
January 9, 2017: Evidence-based Mental Health
https://www.readbyqxmd.com/read/28069457/quercetin-prevents-chronic-unpredictable-stress-induced-behavioral-dysfunction-in-mice-by-alleviating-hippocampal-oxidative-and-inflammatory-stress
#4
Vineet Mehta, Arun Parashar, Malairaman Udayabanu
It is now evident that chronic stress is associated with anxiety, depression and cognitive dysfunction and very few studies have focused on identifying possible methods to prevent these stress-induced disorders. Previously, we identified abundance of quercetin in Urtica dioica extract, which efficiently attenuated stress related complications. Therefore, current study was designed to investigate the effect of quercetin on chronic unpredicted stress (CUS) induced behavioral dysfunction, oxidative stress and neuroinflammation in the mouse hippocampus...
January 7, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28068285/vitamin-k2-improves-anxiety-and-depression-but-not-cognition-in-rats-with-metabolic-syndrome-a-role-of-blood-glucose
#5
Silvia M Gancheva, Maria D Zhelyazkova-Savova
BACKGROUND: The metabolic syndrome is a socially important disorder of energy utilization and storage, recognized as a factor predisposing to the development of depression, anxiety and cognitive impairment in humans. AIM: In the present study we examined the effects of vitamin K2 on the behavior of rats with metabolic syndrome and looked for relationships with the effects on blood sugar. MATERIALS AND METHODS: Male Wistar rats were divided in four groups: a control group on a regular rat chow, a metabolic syndrome (MS) group fed a high-fat high-fructose diet, a control group treated with vitamin K2 and a MS group treated with vitamin K2...
December 1, 2016: Folia Medica
https://www.readbyqxmd.com/read/28067785/relationships-between-gat1-and-ptsd-depression-and-substance-use-disorder
#6
Kaitlin E Bountress, Wei Wei, Christina Sheerin, Dongjun Chung, Ananda B Amstadter, Howard Mandel, Zhewu Wang
Post-traumatic stress disorder (PTSD), Major Depressive Disorder (MDD), and Substance Use Disorder (SUD) have large public health impacts. Therefore, researchers have attempted to identify those at greatest risk for these phenotypes. PTSD, MDD, and SUD are in part genetically influenced. Additionally, genes in the glutamate and gamma-aminobutyric acid (GABA) system are implicated in the encoding of emotional and fear memories, and thus may impact these phenotypes. The current study examined the associations of single nucleotide polymorphisms in GAT1 individually, and at the gene level, using a principal components (PC) approach, with PTSD, PTSD comorbid with MDD, and PTSD comorbid with SUD in 486 combat-exposed veterans...
January 5, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28066008/revisiting-profile-of-deliberate-self-harm-at-a-tertiary-care-hospital-after-an-interval-of-10-years
#7
Paramjeet Singh, Raghav Shah, Purav Midha, Ajitabh Soni, Sunil Bagotia, Kusum Lata Gaur
CONTEXT: Sociocultural factors complement psychopathological factors that result in deliberate self-harm (DSH). A study of change in these factors over time is essential for preventive action. AIMS: To identify factors influencing DSH, which have shown significant variation over a period of 10 years. SETTINGS AND DESIGN: Two hospital-based cross-sectional analytic types of observational studies were performed at two different times at an interval of 10 years...
July 2016: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28065900/exploring-the-predictive-power-of-polygenic-scores-derived-from-genome-wide-association-studies-a-study-of-10-complex-traits
#8
Hon-Cheong So, Pak C Sham
MOTIVATION: It is hoped that advances in our knowledge in disease genomics will contribute to personalized medicine such as individualized preventive strategies or early diagnoses of diseases. With the growth of genome-wide association studies (GWAS) in the past decade, how far have we reached this goal? In this study we explored the predictive ability of polygenic risk scores (PRSs) derived from GWAS for a range of complex disease and traits. RESULTS: We first proposed a new approach to evaluate predictive performances of PRS at arbitrary P-value thresholds...
January 8, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28065208/mental-health-and-psychosocial-problems-in-the-aftermath-of-the-nepal-earthquakes-findings-from-a-representative-cluster-sample-survey
#9
J C Kane, N P Luitel, M J D Jordans, B A Kohrt, I Weissbecker, W A Tol
AIMS: Two large earthquakes in 2015 caused widespread destruction in Nepal. This study aimed to examine frequency of common mental health and psychosocial problems and their correlates following the earthquakes. METHODS: A stratified multi-stage cluster sampling design was employed to randomly select 513 participants (aged 16 and above) from three earthquake-affected districts in Nepal: Kathmandu, Gorkha and Sindhupalchowk, 4 months after the second earthquake. Outcomes were selected based on qualitative preparatory research and included symptoms of depression and anxiety (Hopkins Symptom Checklist-25); post-traumatic stress disorder (PTSD Checklist-Civilian); hazardous alcohol use (AUDIT-C); symptoms indicating severe psychological distress (WHO-UNHCR Assessment Schedule of Serious Symptoms in Humanitarian Settings (WASSS)); suicidal ideation (Composite International Diagnostic Interview); perceived needs (Humanitarian Emergency Settings Perceived Needs Scale (HESPER)); and functional impairment (locally developed scale)...
January 9, 2017: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/28062252/using-neuroimaging-to-individualize-tms-treatment-for-depression-toward-a-new-paradigm-for-imaging-guided-intervention
#10
Bruce M Luber, Simon Davis, Elisabeth Bernhardt, Andrada Neacsiu, Lori Kwapil, Sarah H Lisanby, Timothy J Strauman
The standard clinical technique for using repetitive transcranial magnetic stimulation (rTMS) for major depressive disorder (MDD) is associated with limited efficacy to date. Such limited efficacy may be due to reliance on scalp-based targeting rather than state-of-the-science methods which incorporate fMRI-guided neuronavigation based on a specific model of neurocircuit dysfunction. In this review, we examine such a specific model drawn from regulatory focus theory, which postulates two brain/behavior systems, the promotion and prevention systems, underlying goal pursuit...
January 3, 2017: NeuroImage
https://www.readbyqxmd.com/read/28061819/association-between-a-syndemic-of-psychosocial-problems-and-unprotected-anal-intercourse-among-men-who-have-sex-with-men-in-shanghai-china
#11
Ying Wang, Zezhou Wang, Mengmeng Jia, Ajuan Liang, Dong Yuan, Zhe Sun, Feng Gan, Yichen Wang, Yong Cai, Zhiruo Zhang
BACKGROUND: Previous studies have discussed the overlapping and reinforcing effects (defined as a syndemic) of psychosocial problems on high-risk sexual behaviors among men who have sex with men (MSM). The present study aimed to apply the syndemic theory to verify the reinforcing effects of psychosocial problems on unprotected anal intercourse (UAI) among MSM in Shanghai, and determine if other important psychosocial factors fit into the syndemic theory. METHODS: Data were collected from 547 MSM in Shanghai, China, through face-to-face interviews...
January 7, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28052841/preventing-depression-in-adults-with-subthreshold-depression-health-economic-evaluation-alongside-a-pragmatic-randomized-controlled-trial-of-a-web-based-intervention
#12
Claudia Buntrock, Matthias Berking, Filip Smit, Dirk Lehr, Stephanie Nobis, Heleen Riper, Pim Cuijpers, David Ebert
BACKGROUND: Psychological interventions for the prevention of depression might be a cost-effective way to reduce the burden associated with depressive disorders. OBJECTIVE: To evaluate the cost-effectiveness of a Web-based guided self-help intervention to prevent major depressive disorder (MDD) in people with subthreshold depression (sD). METHODS: A pragmatic randomized controlled trial was conducted with follow-up at 12 months. Participants were recruited from the general population via a large statutory health insurance company and an open access website...
January 4, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28049620/how-do-people-experiencing-schizophrenia-spectrum-disorders-or-other-psychotic-disorders-use-the-internet-to-get-information-on-their-mental-health-literature-review-and-recommendations
#13
Murielle Villani, Viviane Kovess-Masfety
BACKGROUND: Studies show that the Internet has become an influential source of information for people experiencing serious psychiatric conditions such as schizophrenia spectrum disorders or other psychotic disorders, among which the rate of Internet users is growing, with rates ranging from 33.3% to 79.5% given the country. Between 20.5% and 56.4% of these Internet users seek mental health information. OBJECTIVE: Focusing on this population's Web searches about their mental health, this paper examines what type of content they look for and what could be the benefits and disadvantages of this navigation...
January 3, 2017: JMIR Mental Health
https://www.readbyqxmd.com/read/28049069/prevention-of-anxiety-disorders-and-depression-by-targeting-excessive-worry-and-rumination-in-adolescents-and-young-adults-a-randomized-controlled-trial
#14
Maurice Topper, Paul M G Emmelkamp, Ed Watkins, Thomas Ehring
BACKGROUND: This randomized controlled trial evaluated the efficacy of a preventive intervention for anxiety disorders and depression by targeting excessive levels of repetitive negative thinking (RNT; worry and rumination) in adolescents and young adults. METHODS: Participants (N = 251, 83.7% female) showing elevated levels of RNT were randomly allocated to a 6-week cognitive-behavioral training delivered in a group, via the internet, or to a waitlist control condition...
December 23, 2016: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28046205/dietary-advice-interventions-in-pregnancy-for-preventing-gestational-diabetes-mellitus
#15
REVIEW
Joanna Tieu, Emily Shepherd, Philippa Middleton, Caroline A Crowther
BACKGROUND: Gestational diabetes mellitus (GDM) is a form of diabetes occurring during pregnancy which can result in short- and long-term adverse outcomes for women and babies. With an increasing prevalence worldwide, there is a need to assess strategies, including dietary advice interventions, that might prevent GDM. OBJECTIVES: To assess the effects of dietary advice interventions for preventing GDM and associated adverse health outcomes for women and their babies...
January 3, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28045805/predictors-of-depression-and-musculoskeletal-disorder-related-work-disability-among-young-middle-aged-and-aging-employees
#16
Jenni Ervasti, Pauliina Mattila-Holappa, Matti Joensuu, Jaana Pentti, Tea Lallukka, Mika Kivimäki, Jussi Vahtera, Marianna Virtanen
OBJECTIVE: The aim of this study was to investigate the level and predictors of work disability in different age groups. METHODS: We followed young (18 to 34 years), middle-aged (35 to 50 years), and aging (>50 years) employees (n = 70,417) for 7 years (2005 to 2011) for all-cause and cause-specific work disability (sickness absence and disability pension). Using negative binomial regression, we obtained both relative risk estimates and absolute rates, that is, days of work disability per person-year...
January 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28039667/body-dissatisfaction-in-adolescents-with-eating-disorders
#17
Isabel Laporta-Herrero, Ignacio Jáuregui-Lobera, Belén Barajas-Iglesias, Miguel Ángel Santed-Germán
PURPOSE: This study aims to analyze and compare the level of body dissatisfaction (BD) in different eating disorders (ED) subtypes. Also, the relationship between BD and certain aesthetic body shape model influence and psychological variables was analyzed. METHODS: The sample consisted of 204 adolescent patients, who were attending in an ED Unit in Zaragoza (Spain). The following instruments were applied: the Spanish Children's Depression Questionnaire (CEDI-II), the Rosenberg Self-Esteem Scale (RSES), the Eating Attitudes Test (EAT-40), the Body Shape Questionnaire (BSQ-34) and the Questionnaire of Influences of Aesthetic Body shape Model (CIMEC-40)...
December 30, 2016: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/28033564/neighborhood-age-structure-and-cognitive-function-in-a-nationally-representative-sample-of-older-adults-in-the-u-s
#18
Esther M Friedman, Regina A Shih, Mary E Slaughter, Margaret M Weden, Kathleen A Cagney
Recent evidence suggests that living in a neighborhood with a greater percentage of older adults is associated with better individual health, including lower depression, better self-rated health, and a decreased risk of overall mortality. However, much of the work to date suffers from four limitations. First, none of the U.S.-based studies examine the association at the national level. Second, no studies have examined three important hypothesized mechanisms - neighborhood socioeconomic status and neighborhood social and physical characteristics - which are significantly correlated with both neighborhood age structure and health...
December 5, 2016: Social Science & Medicine
https://www.readbyqxmd.com/read/28033521/physical-activity-and-sedentary-behavior-in-people-with-major-depressive-disorder-a-systematic-review-and-meta-analysis
#19
REVIEW
Felipe Schuch, Davy Vancampfort, Joseph Firth, Simon Rosenbaum, Philip Ward, Thaís Reichert, Natália Carvalho Bagatini, Roberta Bgeginski, Brendon Stubbs
BACKGROUND: Low levels of physical activity (PA) and sedentary behavior (SB) are independent risk factors for cardiovascular disease and premature mortality in people with major depressive disorder (MDD). AIMS: Investigate levels of PA and SB and their predictors in people with MDD. METHODS: Electronic databases were searched from inception till 04/2016 for articles measuring PA and SB with a self-report questionnaire (SRQ) or objective measure (e...
November 29, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28031594/suicide-in-rural-central-india-profile-of-attempters-of-deliberate-self-harm-presenting-to-padhar-hospital-in-madhya-pradesh
#20
Johann Alex Ebenezer, Vivek Joge
BACKGROUND: Suicide is a significant public health issue. India currently has the largest number of suicides in the world and has a disproportionate number of youth suicides including young women. The studies on patterns of suicide in rural central India are sparse, particularly among tribal communities. AIMS: The aim of this study is to describe the profile of suicide attempters presenting to a secondary-level hospital in rural central India and identify areas for potential future research toward preventive strategies...
November 2016: Indian Journal of Psychological Medicine
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