Antoine Bruguière, Séverine Derbré, Joël Dietsch, Jules Leguy, Valentine Rahier, Quentin Pottier, Dimitri Bréard, Sorphon Suor Cherer, Guillaume Viault, Anne-Marie Le Ray, Frédéric Saubion, Pascal Richomme
Whether chemists or biologists, researchers dealing with metabolomics require tools to decipher complex mixtures. As a part of metabolomics and initially dedicated to identifying bioactive natural products, dereplication aims at reducing the usually time-consuming process of known compounds isolation. Mass spectrometry and nuclear magnetic resonance are the most commonly reported analytical tools during dereplication analysis. Though low sensitive, 13C-NMR has many advantages for such a study. Noteworthy, it is nonspecific allowing simultaneous high-resolution analysis of any organic compounds including stereoisomers...
June 1, 2020: Analytical Chemistry