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Bikash R Kar, Chinmoy Raj
Background: Lip vitiligo is usually resistant to medical modalities of treatment, and in all these cases, surgery offers a hope. Suction blister grafting (SBG) has been tried since long for lip vitiligo with high rate of success. There have been no long-term follow-up studies of patients with SBG at a difficult-to-treat site like angles of lip, which prompted us to conduct this study. Aims and Objectives: To assess the pigmentation rate and patient satisfaction of SBG on vitiligo involving angles of lip...
January 2018: Journal of Cutaneous and Aesthetic Surgery
Shweta Arora, Bikash Ranjan Kar
BACKGROUND: Suction blister epidermal grafting (SBEG) is a simple and effective way of surgical repigmentation in vitiligo. The major problem faced is the time taken for the formation of blisters. Temperature at the suction site is one of the factors affecting the blister formation time. AIMS AND OBJECTIVES: To reduce the blister formation time in SBEG by increasing the surface temperature to 44°C. MATERIALS AND METHODS: This is a left-right comparison study...
October 2016: Journal of Cutaneous and Aesthetic Surgery
Lihi Atzmony, Ofer Reiter, Emmilia Hodak, Michael Gdalevich, Daniel Mimouni
BACKGROUND: Cutaneous lichen planus (CLP) is an inflammatory dermatosis. Its chronic relapsing course and frequently spontaneous regression hamper the assessment of treatment effectiveness. OBJECTIVE: To evaluate the efficacy of available treatment modalities for CLP. DATA SOURCES: PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), registry. METHODS: We performed a systematic review of the current literature...
February 2016: American Journal of Clinical Dermatology
S Kc, D Karn
No abstract text is available yet for this article.
October 2014: Kathmandu University Medical Journal (KUMJ)
Maxine E Whitton, Mariona Pinart, Jonathan Batchelor, Jo Leonardi-Bee, Urbà González, Zainab Jiyad, Viktoria Eleftheriadou, Khaled Ezzedine
BACKGROUND: Vitiligo is a chronic skin disorder characterised by patchy loss of skin colour. Some people experience itching before the appearance of a new patch. It affects people of any age or ethnicity, more than half of whom develop it before the age of 20 years. There are two main types: generalised vitiligo, the common symmetrical form, and segmental, affecting only one side of the body. Around 1% of the world's population has vitiligo, a disease causing white patches on the skin...
February 24, 2015: Cochrane Database of Systematic Reviews
Pratik Gahalaut, Nitin Mishra, Puneet S Soodan, Madhur K Rastogi
Background. Psoriasis is associated with a high impact on health-related QoL (quality of life). PUVAsol has been successfully used for treating psoriasis instead of standard PUVA therapy in developing countries. However, data for PUVAsol therapy and its effect on QoL in psoriatic patients is meagre. Objective. To investigate the effect of PUVAsol on the quality of life in patients having chronic plaque psoriasis. Materials and Methods. An observational prospective study done in patients having chronic plaque psoriasis...
2014: Dermatology Research and Practice
Pratik Gahalaut, Puneet Singh Soodan, Nitin Mishra, Madhur Kant Rastogi, Hardev Singh Soodan, Sandhya Chauhan
BACKGROUND: Isotretinoin has been used in combination with oral psoralen + UVA (PUVA) and narrowband UVB (NBUVB) for treating psoriasis, especially in women of child-bearing age. The efficacy of oral psoralen + sun exposure (PUVAsol) is comparable to that of PUVA. This study was planned to compare the efficacy of oral PUVAsol with that of the combination of oral isotretinoin and PUVAsol in patients with chronic plaque psoriasis. METHODS: Forty patients with psoriasis vulgaris were randomized to two groups...
December 2014: Photodermatology, Photoimmunology & Photomedicine
Komal Aggarwal, Sujay Khandpur, Neena Khanna, Vinod K Sharma, Chandrakant S Pandav
Psoralen + ultraviolet A (PUVA) therapy is an established modality for psoriasis. As India is a tropical country that has good availability of natural sunlight psoralen + sunlight (PUVAsol) may be a more convenient option. To compare the efficacy and cost-effectiveness of PUVA versus PUVAsol in chronic plaque psoriasis. Cases of chronic plaque psoriasis with body surface area ≥10% or Psoriasis Area and Severity Index (PASI) ≥10, excluding erythrodermic or pustular psoriasis, were randomized to receive either PUVA or PUVAsol, with endpoint being the achievement of PASI 90 or completion of 12 weeks treatment, whichever is earlier...
April 2013: International Journal of Dermatology
Shyam Bhanushankar Verma, Uwe Wollina
Vitiligo is a dreaded disease in India due to its social and cultural consequences. PUVA and PUVAsol are the main treatment modalities for vitiligo vulgaris. To the best of our knowledge, this is the first case of accidental PUVA burns eventuating in prurigo nodularis lesions to be reported in a female patient who was undergoing home PUVA therapy. The itch is so prominent and disabling that the focus of the patient has shifted from treating her vitiligo to ameliorating the pruritus.
November 2012: Anais Brasileiros de Dermatologia
A Hossani-Madani, R Halder
Topical coticosteroids perform better than placebo and topical PUVAsol in repigmenting vitiliginous skin. Topical corticosteroids compare in efficacy to topical calcineurin inhibitors, but produce greater adverse events. Calcineurin inhibitors are more effective in twice daily dosing and may be used on facial areas and in children. Vitamin D analogues are not as effective as topical corticosteroids as monotherapy, but can increase effectiveness of topical steroids in combination therapy. There are no randomized trials examining pseudocatalase monotherapy...
October 2011: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
L Sornakumar, C Shanmuga Sekar, Cr Srinivas
Alopecia areata is characterized by patchy hair loss involving the scalp, eyelashes, and beard. The disease may at times lead to complete baldness of the scalp (alopecia totalis) or of the entire body (alopecia universalis). Alopecia totalis is usually resistant to therapy. We report two cases of alopecia totalis treated with turban psoralen with sunlight exposure (PUVASOL).
July 2010: International Journal of Trichology
S Khandpur, V K Sharma
AIM: Palmoplantar psoriasis (PPP) produces significant morbidity and requires prompt treatment. Topical agents form the mainstay of therapy. We compared the efficacy and side-effect profile of a steroid/coal-tar combination with topical psoralen and solar ultraviolet A (PUVAsol) in PPP. METHODS: In total, 52 patients with PPP were randomized to receive either a combination of clobetasol propionate cream and coal tar daily (group 1) or topical PUVAsol on alternate days (group 2) for 16 weeks...
August 2011: Clinical and Experimental Dermatology
S S Savant
Therapeutic spot or regional dermabrasion was carried out at 64 sites located over cosmetically unimportant hairy areas (52) and non-hairy areas (12) in 15 cases of stable vitiligo. Lesions were individually dermabraded first with either electric or manual dermabraders till pinpoint bleeding occurred. They were further deep demabraded to an appropriate depth manually. On healing, all the 64 sites were further treated with PUVA or PUVASOL. Out of 52 hairy sites 46 sites (88.5%) showed total pigmentation, 2 showed partial pigmentation and in 4 sites there was no pigmentation...
May 1996: Indian Journal of Dermatology, Venereology and Leprology
Nurimar Conceição Fernandes, Juliana Carnevale Pina
Two adolescent females and a girl, all with clinically diagnosed vitiligo, were treated with 0.2% 8-methoxypsoralen cream followed by exposure to solar ultraviolet light. One year later, they developed hypopigmented and achromic spots on the areas affected by the vitiligo. Biopsy of skin tissue taken from one of these cases showed a marked reduction in melanin. Clinical and histological findings point to a diagnosis of leukoderma punctata.
July 2010: Anais Brasileiros de Dermatologia
K Lahiri, S R Sengupta
Sixty cases of stable and refractory depigmented skin conditions which include local vitiligo, segmental vitiligo, chemical leucoderma, vitiligo vulgaris, post-burn depigmentation etc constitute the study group. 39 of them were female and 21 male. Age ranged between 6 and 67 years. 1057 grafts were placed over 114 lesions and the cases were followed up to a period of 18 months. 70% to 100% repigmentation was observed in 56 lesions of 31 patients. Rate and extent of perigraft pigment spread was noted. Patients under PUVASOL showed a distinctly better response...
January 1997: Indian Journal of Dermatology, Venereology and Leprology
S S Savant, S Shenoy
Chemical peeling with 88% phenol was carried out on 142 sites of stable vitiligo (hairy-126, non hairy-16) and on 69 sites of alopecia areata (AA). After cleansing and defatting, phenol was applied on affected areas till a uniform frost appeared. On healing, all the lesions of vitiligo showed perifollicular pigmentation in hairy areas and perilesional repigmentation in non hairy areas. These were further treated with PUVA/PUVASOL. After the healing, 82.5% of hairy sites and 81.3% of non hairy sites showed repigmentation...
March 1999: Indian Journal of Dermatology, Venereology and Leprology
Chembolli Lakshmi, C R Srinivas
A 64-year-old man with generalized papular granuloma annulare of four years duration with frequent relapses and remissions presented with persistent lesions while on 15 mg prednisolone and achieved complete remission with PUVASOL therapy using solarium.
2010: Indian Journal of Dermatology
Aida Khaled, Faten Zeglaoui, Nadia Ezzine, Nadia El Fekih, Becima Fazaa, Mohamed Ridha Kamoun
BACKGROUND: Vitiligo is a frequent hypomelanosis that affects 1% of the world population, and 0,95% of the tunisian population. OBJECTIVE: The objective of our study is to describe through a recent review of the literature, the different therapeutic modalities, now used in vitiligo. We have used a clinical approch to guid therapeutic indications. METHODS: We have performed a review of the articles, dealing with the treatment of vitiligo and published during the 10 previous years...
April 2008: La Tunisie Médicale
C V Rama Sastry, P K Kar
In a random study of 150 patients with psoriasis vulgaris, oral psoralen photochemotherapy using natural sunlight (PUVASOL) used alone was compared to PUVASOL plus adjunctive topical therapy with tar. The combined PUVASOL and topical therapy with tar in 75 patients (group-I) with 30 minutes sunlight exposure done in every alternate day showed complete clearing of lesions in 68 (90.6%) patients. The average rate of clearance of lesions started to appear 12-24 days with a mean of 18 days. Group I patients who received topical therapy in conjunction with PUVASOL, their skin lesions cleared more quickly with fewer treatments at a lower final 15 PUVASOL doses as compared to 22 PUVASOL doses in the control patients...
November 2001: Indian Journal of Dermatology, Venereology and Leprology
P Balasaraswathy, Udaya Kumar, C R Srinivas, Shashidharan Nair
The disadvantages of sunlight as the source of UVA for phototherapy include variation with time, place, season, and atmospheric conditions. In the present study at Coimbatore, India we measured the UVa and UVB irradiance for one year using PMA 2100 meter. UVB irradiance was maximum between 12.00 noon-1.00 p.m (19.50 microw/cm2 to 40.2 microw/cm2) and UVA between 12 noon-1.15 p.m. (4.70 mw/cm2 tp 6.59 mw/cm2). The ratio of UVA was 1:500 to 1:600 during early hours and late evening and 1:200 during mid-day. At peak time (11...
July 2002: Indian Journal of Dermatology, Venereology and Leprology
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