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https://www.readbyqxmd.com/read/29909388/lymphedema-secondary-to-limited-cutaneous-systemic-sclerosis
#1
Sónia Moreira, Jorge Crespo, Lèlita Santos
Systemic sclerosis (SSc) is an autoimmune connective tissue disease characterised by vascular abnormalities, immune system activation and fibrosis. Lymphatic involvement in SSc was described more recently and starts in early stages. This report describes a 46-year-old patient who developed over the last 2 years asymmetric lymphedema in lower extremities. Compromise in lymphatic drainage was confirmed by lymphoscintigraphy. She also presented Raynaud's phenomenon, a scleroderma pattern in nailfold capillaroscopy, cutaneous thickening and anticentromere antibodies, which together resulted in a new diagnosis of limited cutaneous SSc...
June 15, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29909319/simultaneous-determination-of-plasma-methotrexate-and-7-hydroxy-methotrexate-by-uhplc-ms-ms-in-patients-receiving-high-dose-methotrexate-therapy
#2
Shenghui Mei, Xiaoxu Shi, Yaming Du, Yong Cui, Chun Zeng, Xiaohui Ren, Kefu Yu, Zhigang Zhao, Song Lin
The plasma concentrations of methotrexate (MTX) and its major metabolite 7-hydroxy methotrexate (7-OH-MTX) are highly correlated with the toxicities in patients with high-dose MTX therapy. Routine monitoring of MTX and 7-OH-MTX plasma levels is useful for dose adjustment of rescue drugs and toxicity prevention. A UHPLC-MS/MS method for simultaneous determination of plasma MTX and 7-OH-MTX was developed, validated, and applied in 181 plasma samples. The ion transition was m/z 455.2 → 308.2 for MTX and m/z 471...
June 11, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29908669/safety-and-efficacy-of-upadacitinib-in-patients-with-rheumatoid-arthritis-and-inadequate-response-to-conventional-synthetic-disease-modifying-anti-rheumatic-drugs-select-next-a-randomised-double-blind-placebo-controlled-phase-3-trial
#3
Gerd R Burmester, Joel M Kremer, Filip Van den Bosch, Alan Kivitz, Louis Bessette, Yihan Li, Yijie Zhou, Ahmed A Othman, Aileen L Pangan, Heidi S Camp
BACKGROUND: Upadacitinib is a selective inhibitor of Janus kinase 1 and was efficacious in phase 2 studies in patients with moderate-to-severe rheumatoid arthritis. We aimed to assess the efficacy of upadacitinib in patients with inadequate response to conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs). METHODS: This study is a double-blind, placebo-controlled trial at 150 sites in 35 countries. We enrolled patients aged 18 years or older with active rheumatoid arthritis for 3 months or longer, who had received csDMARDs for at least 3 months with a stable dose for at least 4 weeks before study entry, and had an inadequate response to at least one of the following csDMARDs: methotrexate, sulfasalazine, or leflunomide...
June 12, 2018: Lancet
https://www.readbyqxmd.com/read/29908014/randomized-controlled-trials-of-biologic-treatment-with-methotrexate-in-ra-may-not-reflect-real-world-practice-a-systematic-review-and-assessment-of-pragmaticism
#4
May Y Choi, Cheryl Barnabe, Claire E Barber, Vivian Bykerk, Janet E Pope, Glen S Hazlewood
OBJECTIVE: Randomized controlled trials (RCTs) exist along a spectrum, from explanatory, designed to evaluate interventions under ideal conditions, to pragmatic, designed to reflect usual care. This study assessed the pragmaticism of RCTs of advanced therapeutics in rheumatoid arthritis (RA). METHODS: A systematic review was conducted to identify RA RCTs comparing biologic or targeted synthetic therapy in combination with methotrexate, to placebo or any other DMARD(s)...
June 15, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29908009/amphiphilic-y-shaped-miktoarm-star-copolymer-for-anti-cancer-hydrophobic-and-hydrophilic-drugs-co-delivery-synthesis-characterization-in-vitro-and-in-vivo-biocompatibility-study
#5
Mozhgan Aghajanzadeh, Mostafa Zamani, Hamid Rashidzadeh, Kobra Rostamizadeh, Ali Sharafi, Hossein Danafar
In this project, a core-shell Polymersome based on miktoarm star-copolymer: methoxy Poly Ethylene Glycol-Lysine-(Poly Caprolactone)2 (PEG-Lys-PCL2 ) was synthesized by a new method as controlled targeted drug delivery systems for co-delivery of the chemotherapeutic methotrexate (MTX) and curcumin (CUR). Some properties of these nano carriers (NCs) such as surface morphology, structure, surface charge, stability and biocompatibility were evaluated by Proton nuclear magnetic resonance (1 HNMR), dynamic scanning colorimetry (DSC), Fourier-transform infrared spectroscopy (FT-IR), Dynamic light scattering (DLS), atomic force microscopy (AFM), Critical aggregation concentration (CAC), hemolysis test, MTT assay and lethal dose 50 (LD50)...
June 16, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29907672/sex-associated-treatment-differences-and-their-outcomes-in-rheumatoid-arthritis-results-from-the-meteor-register
#6
Sytske Anne Bergstra, Cornelia F Allaart, Sofia Ramiro, Arvind Chopra, Nimmisha Govind, Cândida Silva, Elizabeth A Murphy, Robert B M Landewé
OBJECTIVE: To assess differences in initial treatment and treatment response in male and female patients with rheumatoid arthritis (RA) in daily clinical practice. METHODS: The proportion of patients with RA starting different antirheumatic treatments (disease-modifying antirheumatic drugs; DMARD) and the response to treatment were compared in the international, observational METEOR register. All visits from start of the first DMARD until the first DMARD switch or the end of followup were selected...
June 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29905411/anti-inflammatory-and-antioxidant-effects-of-mesenchymal-and-hematopoietic-stem-cells-in-a-rheumatoid-arthritis-rat-model
#7
Hanan Abdelmawgoud, Asmaa Saleh
BACKGROUND: Mesenchymal stem cells (MSCs) are of increased importance because of their capacity to counteract inflammation and suppress host immune responses. OBJECTIVES: The aim of the study was to compare the effectiveness of MSCs and hematopoietic stem cells (HSCs) in the treatment of rheumatoid arthritis (RA). MATERIAL AND METHODS: Paw swelling was assessed by measuring the thickness of the hind paws using a caliper. Cytokines - interleukin (IL)-6, tumor necrosis factor-alpha (TNF-α), transforming growth factor-beta (TGF-β), and IL-10 - and rheumatoid factor (RF) were measured using enzyme-linked immunosorbent assay (ELISA) kits...
June 15, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29904432/breast-panniculitis-with-liquefactive-fat-necrosis-a-case-report
#8
Yongfeng Zhang, Xuhua Shi, Yuewu Lu
Panniculitis is a group of heterogeneous disorders characterized by inflammation of the subcutaneous adipose tissue. Panniculitis of breast tissue as the initial manifestation has rarely been reported and is often misdiagnosed. Breast panniculitis may cause substantial morbidity and early diagnosis and treatment are important for the prognosis of the disease. The present study has reported a case of panniculitis with inflammation of the mammary glands as the initial presentation and provided a detailed description of ultrasonography, X-ray, computed tomography, magnetic resonance imaging and other imaging features of breast panniculitis...
June 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29904406/systematic-review-and-meta-analysis-of-the-efficacy-and-safety-of-biqi-capsule-in-rheumatoid-arthritis-patients
#9
Xiu-Min Chen, Jia-Qi Wu, Qing-Chun Huang, Jian-Yong Zhang, Jian-Hong Pen, Zhi-Sheng Huang, Yong-Liang Chu, Xiao-Hong He, Mao-Jie Wang, Run-Yue Huang
Biqi capsule is a Traditional Chinese Medicine preparation for treating rheumatoid arthritis (RA), and clinical studies have indicatedthat its effect may be more beneficial than that of Western medicine. The present study aimed to estimate the efficacy and safety of Biqi capsule alone or combined with methotrexate (MTX) compared with MTX alone for treating RA by performing a meta-analysis of randomized controlled trials and controlled clinical trials. A systematic literature search of studies published until March 2017 was performed...
June 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29904314/cutaneous-toxicity-of-oral-low-dose-methotrexate
#10
Priyanka Jalandhara, Gurjit Kaeley
Chemotherapy-induced acral erythema has been a known side effect of intravenous dosing but has not been reported with oral therapy. Herein we describe two patients receiving treatment with low-dose oral methotrexate who presented with acral erythema. Clinicians and rheumatologists should be aware of this potentially serious side effect of oral chemotherapy in various patient populations. This complication related to methotrexate, though rare, should be anticipated in patients on multiple medications who develop mucocutaneous toxicities...
July 2018: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/29903764/inferior-survival-in-high-grade-b-cell-lymphoma-with-myc-and-bcl2-and-or-bcl6-rearrangements-is-not-associated-with-myc-ig-gene-rearrangements
#11
Ellen D McPhail, Matthew J Maurer, William R Macon, Andrew L Feldman, Paul J Kurtin, Rhett P Ketterling, Rakhee Vaidya, James R Cerhan, Stephen M Ansell, Luis F Porrata, Grzegorz S Nowakowski, Thomas E Witzig, Thomas M Habermann
High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements (double-/triple-hit lymphoma) has an aggressive clinical course. We investigated prognostic value of transformation from low-grade lymphoma, cytologic features (high grade versus large cell), MYC gene rearrangement partners (immunoglobulin versus nonimmunoglobulin gene), and treatment. We evaluated 100 adults with double-/triple-hit lymphoma, reviewing cytologic features; cell of origin; and rearrangements of MYC, BCL2, and BCL6 using MYC, BCL2, and BCL6 break-apart and IGH/MYC, IGL/MYC, IGK/MYC, and IGH/BCL2 dual-fusion interphase fluorescence in situ hybridization probes...
June 14, 2018: Haematologica
https://www.readbyqxmd.com/read/29902867/a-single-dose-of-the-antineoplastics-hydroxyurea-or-cisplatin-has-praziquantel-like-effects-on-schistosoma-mansoni-worms-and-host-mouse-liver
#12
Eman Eldeeb, Shereen Fahmy, Kadry Elbakry, Ayman Hyder
Increasing resistance to praziquantel, the only available antischistosomal drug, is always developed by schistosomes. The recent description of stem cell-like neoblasts in schistosomes led to the idea of applying antineoplastic drugs as antischistosomal agents that may inhibit stem cell divisions and retard worm regeneration. Here, we explored the in vitro and in vivo effect of some antineoplastic drugs on S. mansoni worm and the host mouse liver. S. mansoni worms' viability was tested after exposure to either praziquantel or one of the antitumor drugs (hydroxyurea, cisplatin, methotrexate, and colchicine) in vitro for 24 and 48 h...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29901407/vaccination-with-a-novel-antigen-specific-tolerizing-dna-vaccine-encoding-ccol2a1-protects-rats-from-experimental-rheumatoid-arthritis
#13
Xiao Zhao, Juan Long, Fei Liang, Nan Liu, Yuying Sun, Yongzhi Xi
Antigen-specific tolerizing DNA vaccines are one of the most promising strategies for rheumatoid arthritis (RA) treatment, and act by inducing potent immune tolerance instead of generalized immunosuppression. Recently, we developed a novel antigen-specific tolerizing DNA vaccine coding for chicken type II collagen (pcDNA-CCOL2A1), and confirmed its potent therapeutic efficacy in an established rat model of collagen-induced arthritis (CIA). Here we report the prophylactic vaccination efficacy of a single 300ug/kg dose of pcDNA-CCOL2A1 against CIA incidence, severity, and onset...
June 14, 2018: Human Gene Therapy
https://www.readbyqxmd.com/read/29900970/the-association-of-anti-aminoacyl-transfer-ribonucleic-acid-synthetase-antibodies-in-patients-with-rheumatoid-arthritis-and-interstitial-lung-disease
#14
Masakazu Matsushita, Naoto Tamura, Michihiro Ogasawara, Kurisu Tada, Ken Yamaji, Yoshinari Takasaki
Objectives: This study aims to analyze the distribution and clinicopathological characteristics of anti-aminoacyl-transfer ribonucleic acid (tRNA) synthetase (ARS) antibodies in rheumatoid arthritis patients. Patients and methods: We retrospectively studied the anti-ARS antibody levels in 228 RA patients' (44 males, 184 females; mean age 62.9±14.0 years; range 23 to 88 years) sera from their medical charts. We determined the association with anti-cyclic citrullinated peptide antibody levels, interstitial lung disease (ILD), rheumatoid factor, and methotrexate or biological disease modifying antirheumatic drug treatments...
March 2018: Archives of Rheumatology
https://www.readbyqxmd.com/read/29900829/alternative-tumour-necrosis-factor-inhibitors-tnfi-or-abatacept-or-rituximab-following-failure-of-initial-tnfi-in-rheumatoid-arthritis-the-switch-rct
#15
Sarah Brown, Colin C Everett, Kamran Naraghi, Claire Davies, Bryony Dawkins, Claire Hulme, Christopher McCabe, Sue Pavitt, Paul Emery, Linda Sharples, Maya H Buch
BACKGROUND: Rheumatoid arthritis (RA), the most common autoimmune disease in the UK, is a chronic systemic inflammatory arthritis that affects 0.8% of the UK population. OBJECTIVES: To determine whether or not an alternative class of biologic disease-modifying antirheumatic drugs (bDMARDs) are comparable to rituximab in terms of efficacy and safety outcomes in patients with RA in whom initial tumour necrosis factor inhibitor (TNFi) bDMARD and methotrexate (MTX) therapy failed because of inefficacy...
June 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29898484/-drug-prescribing-for-patients-with-chronic-kidney-disease-in-general-practice-a-cross-sectional-study
#16
Maria Mahner, Christina Raus, Fabian Ludwig, Gesine Weckmann, Sylvia Stracke, Jean-François Chenot
BACKGROUND:  Many drugs require dose adjustment or are contraindicated in patients with chronic kidney disease (CKD) to avoid adverse events. The aims of this study were to assess if medication was appropriately dose adjusted in patients with CKD in primary care, to identify medications that were frequently prescribed inappropriately and to identify factors predicting mal-prescription. METHODS:  We conducted a cross-sectional observational study in 34 general practioners' offices, assessing the medication of patients with CKD stage ≥ 3 according to the corresponding pharmaceutical product information...
June 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29897226/alleviating-the-liver-toxicity-of-chemotherapy-via-ph-responsive-hepatoprotective-prodrug-micelles
#17
Ran Tao, Min Gao, Fang Liu, Xuliang Guo, Aiping Fan, Dan Ding, Deling Kong, Zheng Wang, Yanjun Zhao
Nanocarriers have been extensively utilized to enhance the anti-tumor performance of chemotherapy, but it is very challenging to eliminate the associated hepatotoxicity. This was due to the significant liver accumulation of cytotoxic drug-loaded nanocarriers as a consequence of systemic biodistribution. To address this, we report a novel type of nanocarrier that was made of hepatoprotective compound (oleanolic acid/OA) with a model drug (methotrexate/MTX) being physically encapsulated. OA was covalently connected with methoxy poly(ethylene glycol) (mPEG) via a hydrazone linker, generating amphiphilic mPEG-OA prodrug conjugate that could self-assemble into pH-responsive micelles (ca...
June 13, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29897127/building-the-evidence-base-for-current-systemic-treatments-for-severe-chronic-atopic-dermatitis-methotrexate-vs-azathioprine
#18
L B von Kobyletzki, Å Svensson
No abstract text is available yet for this article.
June 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29897007/an-economic-evaluation-of-tofacitinib-treatment-in-rheumatoid-arthritis-after-methotrexate-or-after-1-or-2-tnf-inhibitors-from-a-u-s-payer-perspective
#19
Lindsay Claxton, Matthew Taylor, Arif Soonasra, Jeffrey A Bourret, Robert A Gerber
BACKGROUND: Treatment cycling with biologic disease-modifying anti-rheumatic drugs, such as tumor necrosis factor inhibitors (TNFi), is common among patients with rheumatoid arthritis (RA) and can result in reduced clinical efficacy and increased economic burden. Tofacitinib is an oral Janus kinase inhibitor for the treatment of RA. OBJECTIVE: To evaluate and compare the economic effect of tofacitinib 5 mg twice daily (BID) treatment directly after methotrexate (MTX) in the MTX-inadequate responder population, or after MTX and 1 TNFi (adalimumab [ADA] or etanercept [ETN]) or 2 TNFi (ADA and ETN) in TNF-inadequate responder patients with RA, from a U...
June 13, 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29895929/hepatic-veno-occlusive-disease-following-sirolimus-based-immune-suppression
#20
Farhad Khimani, George B McDonald, Howard M Shulman, Brian Betts, Frederick Locke, Hugo Fernandez, Claudio Anasetti, Joseph Pidala
Sirolimus-based graft vs. host disease (GVHD) prophylaxis is associated with higher incidence of veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) after allogeneic hematopoietic cell transplantation (HCT). However, whether the clinical manifestations and prognosis of VOD/SOS differs when diagnosed in the setting of sirolimus-based GVHD prophylaxis is not well studied. To address this question, we examined presenting features and treatment outcome of VOD/SOS cases identified in a large retrospective cohort of consecutive HCT procedures (n = 818 total, sirolimus (SIR)/tacrolimus (TAC) n = 308, and methotrexate (MTX) or mycophenolate mofetil (MMF)/TAC n = 510)...
June 12, 2018: Bone Marrow Transplantation
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