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https://www.readbyqxmd.com/read/29913476/a-new-amphetamine-oral-suspension-adzenys-er-for-adhd
#1
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No abstract text is available yet for this article.
June 18, 2018: Medical Letter on Drugs and Therapeutics
https://www.readbyqxmd.com/read/29913457/anti-inflammatory-action-of-sitagliptin-and-linagliptin-in-doxorubicin-nephropathy
#2
Chor Ho Jo, Sua Kim, Joon-Sung Park, Gheun-Ho Kim
BACKGROUND/AIMS: Dipeptidyl peptidase-4 (DPP4) inhibitors are known to have a protective effect on diabetic kidney disease, possibly via reduction of oxidative stress and inflammation in the kidney. However, whether these potential mechanisms play a role in non-diabetic proteinuric kidney diseases is not clear. METHODS: Two different animal experiments were carried out using sitagliptin and linagliptin for DPP4 inhibition. In each experiment, male Sprague-Dawley rats were uninephrectomized and randomly divided into vehicle-treated and doxorubicin-treated rats, with or without DPP4 inhibition...
June 15, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29913456/long-term-oral-administration-of-theaphenon-e-improves-cardiomyocyte-mechanics-and-calcium-dynamics-by-affecting-phospholamban-phosphorylation-and-atp-production
#3
Leonardo Bocchi, Monia Savi, Valeria Naponelli, Rocchina Vilella, Gianluca Sgarbi, Alessandra Baracca, Giancarlo Solaini, Saverio Bettuzzi, Federica Rizzi, Donatella Stilli
BACKGROUND/AIMS: Dietary polyphenols from green tea have been shown to possess cardio-protective activities in different experimental models of heart diseases and age-related ventricular dysfunction. The present study was aimed at evaluating whether long term in vivo administration of green tea extracts (GTE), can exert positive effects on the normal heart, with focus on the underlying mechanisms. METHODS: The study population consisted of 20 male adult Wistar rats...
June 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29913447/perioperative-anaphylaxis-including-kounis-syndrome-due-to-selective-cefazolin-allergy
#4
Inês Mota, Ângela Gaspar, Mário Morais-Almeida
BACKGROUND: Perioperative use of cefazolin has been associated with severe allergic reactions, and patients are usually labelled as allergic to penicillin afterwards. The aim of our study was to describe a group of patients with immediate reactions to cefazolin, with proven selective hypersensitivity reactions. METHODS: Systematic review of all patients followed at our drug centre with cefazolin-related reactions, between January 2012 and December 2016. All patients were investigated according to the European Network for Drug Allergy (ENDA) recommendations through skin testing (major and minor penicillin determinants, penicillin, amoxicillin, cefazolin, cefuroxime and ceftriaxone) and oral challenges tests...
June 18, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29913431/five-decade-delayed-closed-flexor-tendon-rupture-due-to-galeazzi-dislocation-fracture-associated-with-beh%C3%A3-et-syndrome-a-case-report
#5
Masato Ohara, Ryo Oda, Shogo Toyama, Yusei Katsuyama, Hiroyoshi Fujiwara, Toshikazu Kubo
INTRODUCTION: Closed flexor tendon rupture after a malunited distal radius fracture is rare and usually becomes apparent early after the fracture. Most cases are accompanied by a severe distal radio-ulnar joint capsule injury, wherein bone protrusion (as a spur) directly stresses the tendons. We experienced a nonspecific flexor tendon rupture associated with an old fracture and the presence of collagen disease. PRESENTATION OF CASE: A 63-year-old woman presented with delayed complete rupture of the flexor digitorum profundus (FDP) of the fifth digit...
May 29, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29913322/culture-supernatants-of-oral-cancer-cells-induce-impaired-ifn-%C3%AE-production-of-pdcs-partly-through-the-down-regulation-of-tlr-9-expression
#6
Nannan Han, Zun Zhang, Houyu Jv, Jingzhou Hu, Min Ruan, Chenping Zhang
OBJECTIVES: The aim of the present study was to investigate whether tumor-derived supernatants down-regulate the immune function of plasmacytoid dendritic cells (pDCs) in oral cancer and the potential molecular mechanisms of this effect. MATERIALS AND METHODS: Immunohistochemistry (IHC) and flow cytometry were used to detect tumor-infiltrating and peripheral blood pDCs. MTS and flow cytometry were employed to evaluate the immune response of CD4+ T cells. Real-time PCR and ELISA assays were used to identify TLR-7 and TLR-9 expression, IFN-α production and tumor-secreted soluble cytokines...
June 5, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29913298/antihypertensive-effect-of-the-methanolic-extract-from-eruca-sativa-mill-brassicaceae-in-rats-muscarinic-receptor-linked-vasorelaxant-and-cardiotonic-effects
#7
Umme Salma, Taous Khan, Abdul Jabbar Shah
ETHNOPHARMACOLOGICAL RELEVANCE: Eruca sativa Mill., (Brassicaceae) is a popular remedy for the treatment of hypertension in Pakistan. However, direct effect of the extract and its fractions on blood pressure and vascular tone are unknown. AIM OF THE STUDY: This investigation was aimed to explore the pharmacological base for the traditional use of E. sativa in hypertension. MATERIALS AND METHODS: In-vivo blood pressure study was carried out using normotensive and high salt-induced hypertensive rats under anaesthesia...
June 15, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29913234/the-ameliorative-effects-of-boron-against-acrylamide-induced-oxidative-stress-inflammatory-response-and-metabolic-changes-in-rats
#8
Ulas Acaroz, Sinan Ince, Damla Arslan-Acaroz, Zeki Gurler, Ismail Kucukkurt, Hasan Hüseyin Demirel, Halil Ozancan Arslan, Nuray Varol, Kui Zhu
Acrylamide (ACR) is a hazardous substance associated with the accumulation of excessive reactive oxygen species and causes oxidative stress. Presence of ACR in foods leads to public health concerns due to its known neurotoxic, genotoxic, and carcinogenic effects. The present study investigated the ameliorative effects of boron (B) against ACR exposed rats. Forty Wistar albino male rats, fed with low-boron diet, were randomly and equally allocated into 5 groups. The control group was orally treated with physiological saline as placebo, the second group was orally given 15 mg/kg ACR...
June 15, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29913205/ethical-approval-for-multicenter-cohort-studies-on-drug-exposure-during-pregnancy-a-survey-among-members-of-the-european-network-of-teratology-information-services-entis
#9
Ursula Winterfeld, Corinna Weber-Schöndorfer, Christof Schaefer, Erik von Elm, Thierry Buclin
The European Network of Teratology Information Services (ENTIS) is in a privileged position to perform independent post-marketing surveillance of drugs in pregnancy. The aim of this survey was to describe the legal requirements and procedures involved in obtaining ethical approval for collaborative cohort studies. We sent a survey questionnaire to all 28 Teratology Information Services (TIS), of which 25 (89%) in 18 countries completed our questionnaire. For 15 TIS, specific research ethical approval was mandatory...
June 15, 2018: Reproductive Toxicology
https://www.readbyqxmd.com/read/29913186/blockade-of-t-type-calcium-channels-by-6-prenylnaringenin-a-hop-component-alleviates-neuropathic-and-visceral-pain-in-mice
#10
Fumiko Sekiguchi, Tomoyo Fujita, Takahiro Deguchi, Sakura Yamaoka, Ken Tomochika, Maho Tsubota, Sumire Ono, Yamato Horaguchi, Maki Ichii, Mio Ichikawa, Yumiko Ueno, Nene Koike, Tadatoshi Tanino, Huy Du Nguyen, Takuya Okada, Hiroyuki Nishikawa, Shigeru Yoshida, Tsuyako Ohkubo, Naoki Toyooka, Kazuya Murata, Hideaki Matsuda, Atsufumi Kawabata
Since Cav 3.2 T-type Ca2+ channels (T-channels) expressed in the primary afferents and CNS contribute to intractable pain, we explored T-channel-blocking components in distinct herbal extracts using a whole-cell patch-clamp technique in HEK293 cells stably expressing Cav 3.2 or Cav 3.1, and purified and identified sophoraflavanone G (SG) as an active compound from SOPHORAE RADIX (SR). Interestingly, hop-derived SG analogues, (2S)-6-prenylnaringenin (6-PNG) and (2S)-8-PNG, but not naringenin, also blocked T-channels; IC50 (μM) of SG, (2S)-6-PNG and (2S)-8-PNG was 0...
June 15, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29913093/recent-advances-in-the-etiology-and-treatment-of-burning-mouth-syndrome
#11
A Ritchie, J M Kramer
Burning mouth syndrome (BMS) is a debilitating condition that has a striking female predilection. Although the oral mucosa is normal in appearance, patients with BMS experience oral burning that most commonly localizes to the lips and tongue. BMS is a diagnosis of exclusion, and all underlying pathoses associated with allodynia must be ruled out prior to rendering the diagnosis. The etiopathogenesis of BMS remains poorly understood, and thus patient management is challenging. Data indicate that oral and systemic factors both contribute to the development and persistence of the condition...
June 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29913090/oral-chemotherapy-for-the-treatment-of-hepatocellular-carcinoma
#12
Shun Yamamoto, Shunsuke Kondo
Many clinical trials have been conducted with chemotherapies in patients with advanced hepatocellular carcinoma (HCC). However, few agents have shown efficacy. It is thought that the efficacy of some agents might have resulted from the heterogeneity of tumors, insufficient dosages due to liver cirrhosis, and post-therapy effects. In recent years, immune checkpoint inhibitors have shown promising clinical activity and safety in patients with advanced HCC. Areas covered: The authors provide an overview of chemotherapies used for the treatment of HCC, including ongoing trials...
June 18, 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29913024/laser-pointer-induced-maculopathy-more-than-meets-the-eye
#13
Kamal Mtanes, Michael Mimouni, Shiri Zayit-Soudry
PURPOSE: To describe the clinical findings in patients with laser-induced retinal injury. METHODS: Consecutive patients presenting to a tertiary center between January 2014 and December 2015 following inadvertent ocular exposure to a laser pointer were included. Evaluation included a full ophthalmic examination and spectral-domain optical coherence tomography (SD-OCT). RESULTS: Seven young patients (8 eyes) were identified. Their mean age was 18...
June 18, 2018: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29912919/frequency-of-speech-disruptions-in-parkinson-s-disease-and-developmental-stuttering-a-comparison-among-speech-tasks
#14
Fabiola Staróbole Juste, Fernanda Chiarion Sassi, Julia Biancalana Costa, Claudia Regina Furquim de Andrade
OBJECTIVE: To analyze the frequency of speech disruptions across different speech tasks, comparing the performance of individuals with Parkinson's Disease (PD) and DS. METHOD: Participants were 20 people with PD, 20 people with DS and 40 fluent individuals. Speech samples were recorded during monologue speech, choral and solo oral reading. Transcriptions of 200 fluent syllables were performed to identify stuttering-like disfluencies (SLDs) and other disfluencies (ODs)...
2018: PloS One
https://www.readbyqxmd.com/read/29912915/visual-attention-span-performance-in-german-speaking-children-with-differential-reading-and-spelling-profiles-no-evidence-of-group-differences
#15
Chiara Banfi, Ferenc Kemény, Melanie Gangl, Gerd Schulte-Körne, Kristina Moll, Karin Landerl
An impairment in the visual attention span (VAS) has been suggested to hamper reading performance of individuals with dyslexia. It is not clear, however, if the very nature of the deficit is visual or verbal and, importantly, if it affects spelling skills as well. The current study investigated VAS by means of forced choice tasks with letters and symbols in a sample of third and fourth graders with age-adequate reading and spelling skills (n = 43), a typical dyslexia profile with combined reading and spelling deficits (n = 26) and isolated spelling deficits (n = 32)...
2018: PloS One
https://www.readbyqxmd.com/read/29912913/pilot-assessment-of-probiotics-for-pregnant-women-in-rwanda
#16
Amy McMillan, Stephen Rulisa, Gregory B Gloor, Jean M Macklaim, Mark Sumarah, Gregor Reid
BACKGROUND: While the global market for probiotics is soon to reach in excess of US$50 billion, the continent of Africa has been largely ignored, despite these products having the ability to reduce the burden of disease and death. TRIAL DESIGN: The present randomised, blinded, placebo-controlled clinical trial was undertaken in Rwanda, a country devoid of well-documented probiotics. The primary outcome aim was to examine receptivity and compliance for orally administered probiotic capsules containing Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 in pregnant women and assess any initial side effects or changes to the vaginal microbiome...
2018: PloS One
https://www.readbyqxmd.com/read/29912794/intraindividual-and-interindividual-variability-of-olanzapine-trough-concentrations-in-patients-treated-with-the-long-acting-injectable-formulation
#17
Sara Baldelli, Massimo C Mauri, Chiara Di Pace, Silvia Paletta, Alessandra Reggiori, Chiara Rovera, Emilio Clementi, Dario Cattaneo
BACKGROUND: A long-acting injectable (LAI) formulation of olanzapine has been developed as an alternative to oral regimens. A therapeutic range of 20 to 80 ng/mL for oral olanzapine trough concentrations has been proposed. Here, we sought to investigate the intraindividual and interindividual variability of olanzapine concentrations with time in patients on maintenance therapy with the LAI formulation carried out in the routine clinical practice. METHODS: To address this issue, we carried out a retrospective analysis of therapeutic drug monitoring of olanzapine concentrations in 21 schizophrenic patients on maintenance LAI olanzapine...
June 14, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29912762/oral-and-otorhinolaryngological-findings-in-adults-who-were-diagnosed-with-pediatric-onset-crohn-s-disease-a-controlled-study
#18
Anu Haaramo, Heikki Alapulli, Liisa Aine, Jetta Tuokkola, Ulla Saarnisto, Risto P Roine, Anne Pitkäranta, Kaija-Leena Kolho
BACKGROUND: Up to 50% of pediatric patients with Crohn's disease (CD) report oral manifestations, but less is known about their oral health when they become adults. GOALS: Our aim was to provide detailed descriptions of the presence of oral and otorhinolaryngological manifestations in patients with pediatric onset CD once they reached adulthood, to look for predisposing factors and to compare the findings to matched controls. STUDY: Adult patients diagnosed with CD in childhood at the Children's Hospital, University of Helsinki, Finland, after 2000 were invited for a follow-up appointment in 2016 and 24 were examined by a dentist and otorhinolaryngologist...
June 16, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29912679/oral-indomethacin-versus-oral-ibuprofen-for-treatment-of-patent-ductus-arteriosus-a-randomised-controlled-study-in-very-low-birthweight-infants
#19
Varangthip Khuwuthyakorn, Chuleeporn Jatuwattana, Suchaya Silvilairat, Watcharee Tantiprapha
Background In low- and middle-income countries (LMIC), haemodynamically significant patent ductus arteriosus (hsPDA) is treated with oral indomethacin (IDC) and ibuprofen (IB) instead of intravenous formulations. No significant differences in efficacy have been reported. However, previous studies had small numbers of VLBW infants (<1500 g). Objective To evaluate the efficacy of oral IDC and IB for closing PDA in VLBW infants with a gestational age of 24-32 weeks. Methods This randomised controlled study enrolled 32 infants with hsPDA for treatment with either three doses of oral IDC or oral IB...
June 18, 2018: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/29912623/saxagliptin-upregulates-nesfatin-1-secretion-and-ameliorates-insulin-resistance-and-metabolic-profiles-in-type-2-diabetes-mellitus
#20
Kuanlin Chen, Tiejun Zhuo, Jian Wang, Qing Mei
BACKGROUND AND AIMS: Saxagliptin as one of dipeptidyl peptidase-4 (DPP-4) inhibitors can effectively improve glycaemic control in type 2 diabetes mellitus, and nesfatin-1 is regarded as a very important factor in regulating feeding behavior and energy homeostasis. In this trial, we observed the effect of saxagliptin on regulating nesfatin-1 secretion and ameliorating insulin resistance and metabolic profiles in type 2 diabetes mellitus. METHODS: One hundred two type 2 diabetes participants (M/F = 48/54) were investigated...
June 18, 2018: Metabolic Syndrome and related Disorders
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