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https://www.readbyqxmd.com/read/28855547/tylophorine-analogs-allosterically-regulates-heat-shock-cognate-protein-70-and-inhibits-hepatitis-c-virus-replication
#1
Ying Wang, Sangwon Lee, Ya Ha, Wing Lam, Shao-Ru Chen, Ginger E Dutschman, Elizabeth A Gullen, Susan P Grill, Yao Cheng, Alois Fürstner, Samson Francis, David C Baker, Xiaoming Yang, Kuo-Hsiung Lee, Yung-Chi Cheng
Tylophorine analogs have been shown to exhibit diverse activities against cancer, inflammation, arthritis, and lupus in vivo. In this study, we demonstrated that two tylophorine analogs, DCB-3503 and rac-cryptopleurine, exhibit potent inhibitory activity against hepatitis C virus (HCV) replication in genotype 1b Con 1 isolate. The inhibition of HCV replication is at least partially mediated through cellular heat shock cognate protein 70 (Hsc70). Hsc70 associates with the HCV replication complex by primarily binding to the poly U/UC motifs in HCV RNA...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28795238/efficacy-and-safety-of-sofosbuvir-based-interferon-free-therapy-the-management-of-rheumatologic-extrahepatic-manifestations-associated-with-chronic-hepatitis-c%C3%A2-virus-infection
#2
A A Shahin, H S Zayed, M Said, S A Amer
BACKGROUND: The use of pegylated interferon alpha (IFN) has been of concern in chronic hepatitis C virus (HCV) patients with rheumatologic extrahepatic manifestations (EHM) due to the immunostimulatory effects of IFN. AIM: To study the efficacy and safety of sofosbuvir-based, IFN-free antiviral therapy in chronic HCV patients with rheumatologic EHM. MATERIAL AND METHODS: Group A included 24 patients with arthropathy (arthralgia or arthritis, n = 15) or vasculitis (n = 9) who received sofosbuvir and ribavirin (n = 17) or sofosbuvir and simeprevir (n = 7)...
August 9, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28723711/epidemiology-of-autoimmune-and-inflammatory-diseases-in-a-french-nationwide-hiv-cohort
#3
D Lebrun, M Hentzien, L Cuzin, D Rey, V Joly, L Cotte, C Allavena, P Dellamonica, A Servettaz, F Bani-Sadr
HIV infection and inflammatory and autoimmune diseases (IAD) are both related to immune dysfunction. Epidemiological data on IAD in patients living with HIV (PLHIV) are scarce. The aim of this study was thus to estimate the prevalence of 26 IAD among PLHIV followed in a large French multicenter cohort in the cART era (from January 2000 to July 2013), and to describe their occurrence according to cART onset, the immuno-virological status of patients and HCV and/or HBV co-infection.During the study period, 33 403 PLHIV were included in the Dat'AIDS cohort; 1381 patients with an IAD were identified...
July 18, 2017: AIDS
https://www.readbyqxmd.com/read/28700530/retrospective-study-of-patients-on-etanercept-therapy-for-rheumatic-diseases-in-patients-with-chronic-hepatitis-c-virus
#4
Nisarg P Gandhi, Augustine M Manadan, Joel A Block
OBJECTIVE: Treatment of rheumatic diseases with concurrent hepatitis C virus (HCV) infection is a therapeutic challenge. Etanercept has no known hepatotoxicity; however there is a concern for worsening of HCV infection-related liver disease due to immunosuppressive action of the drug. Here, we retrospectively assessed the safety of etanercept in rheumatologic disease in patients with chronic HCV. METHODS: A retrospective review was conducted in patients with chronic HCV infection who received etanercept for diagnosis of rheumatoid arthritis and psoriatic arthritis...
August 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28629188/serum-biomarkers-for-discrimination-between-hepatitis-c-related-arthropathy-and-early-rheumatoid-arthritis
#5
Isabela Siloşi, Lidia Boldeanu, Viorel Biciuşcă, Maria Bogdan, Carmen Avramescu, Citto Taisescu, Vlad Padureanu, Mihail Virgil Boldeanu, Anica Dricu, Cristian Adrian Siloşi
In the present study, we aimed to estimate the concentrations of cytokines (interleukin 6, IL-6, tumor necrosis factor-α, TNF-α) and auto-antibodies (rheumatoid factor IgM isotype, IgM-RF, antinuclear auto-antibodies, ANA, anti-cyclic citrullinated peptide antibodies IgG isotype, IgG anti-CCP3.1, anti-cardiolipin IgG isotype, IgG anti-aCL) in serum of patients with eRA (early rheumatoid arthritis) and HCVrA (hepatitis C virus-related arthropathy) and to assess the utility of IL-6, TNF-α together with IgG anti-CCP and IgM-RF in distinguishing between patients with true eRA and HCVrA, in the idea of using them as differential immunomarkers...
June 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28532574/prevalence-and-correlates-of-hepatitis-c-virus-associated-inflammatory-arthritis-in-a-population-based-cohort
#6
Elizabeth D Ferucci, Tammy L Choromanski, Danielle T Varney, Holly S Ryan, Lisa J Townshend-Bulson, Brian J McMahon, Mark H Wener
OBJECTIVES: The objectives of this study were to determine the prevalence of hepatitis C virus-associated inflammatory arthritis, to describe its clinical and immunologic correlates, and to identify features that are characteristic of arthritis in chronic hepatitis C. METHODS: Participants with chronic hepatitis C infection enrolled in a population-based cohort study in Alaska and who had not received anti-viral treatment for hepatitis C were recruited. In a cross-sectional study, we assessed joint symptoms and signs, performed autoantibody and cytokine testing, and abstracted medical records for features of hepatitis C and arthritis...
April 24, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28516869/recommendations-for-infectious-disease-screening-in-migrants-to-western-europe-with-inflammatory-arthropathies-before-starting-biologic-agents-results-from-a-multidisciplinary-task-force-of-four-european-societies-sir-ser-simet-semtsi-facing-the-largest-impact
#7
Filippo Bartalesi, Carlo Scirè, Ana Requena-Méndez, Miguel Angel Abad, Dora Buonfrate, Roberto Caporali, Fabrizio Conti, Federico Diaz-Gonzalez, Cruz Fernández-Espartero, Carmen Martinez-Fernandez, Marta Mascarello, Elena Generali, Giovanni Minisola, Aldo Morrone, José Muñoz, Patricia Richi, Gariffalia Sakellariou, Joaquin Salas Coronas, Michele Spinicci, Francesco Castelli, Alessandro Bartoloni, Zeno Bisoffi, Francisco Gimenez-Sanchez, Santiago Muñoz-Fernandez, Marco Matucci-Cerinic
OBJECTIVES: Inflammatory arthritis needs infectious disease screening before starting a biologic agent, however, few data are known about migrant patients, who represent a peculiar population which requires a multidisciplinary approach among international health specialists and should also be considered by health authorities. For this reason, the Italian and Spanish Societies of Rheumatology (SIR and SER) and Tropical Medicine (SIMET and SEMTSI) promoted a multidisciplinary task force in order to produce specific recommendations about screening and advices to be considered in migrant patients with inflammatory arthritis candidate to receive biological therapy, according to their geographical origin...
September 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28507447/managing-refractory-cryoglobulinemic-vasculitis-challenges-and-solutions
#8
REVIEW
Predrag Ostojic, Ivan R Jeremic
Cryoglobulinemia is thought to be a rare condition. It may be an isolated disorder or secondary to a particular disease. According to immunoglobulin composition, cryoglobulinemia is classified into three types. In mixed cryoglobulinemia (types II and III), vascular deposition of cryoglobulin-containing immune complexes and complement may induce a clinical syndrome, characterized by systemic vasculitis and inflammation - cryoglobulinemic vasculitis (CryoVas). Most common clinical manifestations in CryoVas are skin lesions (orthostatic purpura and ulcers), weakness, peripheral neuropathy, Raynaud's phenomenon, sicca syndrome, membranoproliferative glomerulonephritis, and arthralgia and seldom arthritis...
2017: Journal of Inflammation Research
https://www.readbyqxmd.com/read/28392862/role-of-lncrna-af085935-il-10-and-il-17-in-rheumatoid-arthritis-patients-with-chronic-hepatitis-c
#9
Dina Sabry, Azza Elamir, Rania Hosny Mahmoud, Ahmed Ali Abdelaziz, Wael Fathy
BACKGROUND: The current study aimed at testing the effect of corticosteroid therapy on serum levels of interleukin-10 (IL-10) and IL-17 as well as lncRNA-AF085935 in patients of rheumatoid arthritis (RA) associated with hepatitis C virus (HCV) and evaluating the usefulness of using these parameters to predict the therapeutic efficacy of steroids in these patients. METHODS: Thirty healthy control subjects and 65 chronic HCV patients with RA were included in our study...
May 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28250142/safety-of-biologic-and-nonbiologic-disease-modifying-antirheumatic-drug-therapy-in-veterans-with-rheumatoid-arthritis-and-hepatitis-c-virus-infection
#10
Mary Jane Burton, Jeffrey R Curtis, Shuo Yang, Lang Chen, Jasvinder A Singh, Ted R Mikuls, Kevin L Winthrop, John W Baddley
OBJECTIVE: To examine the effect of disease-modifying antirheumatic drug (DMARD) therapy on hepatotoxicity among patients with rheumatoid arthritis (RA) and hepatitis C virus (HCV) infection. METHODS: We identified biologic and nonbiologic treatment episodes of patients with RA using the 1997-2011 national data from the US Veterans Health Administration. Eligible episodes had HCV infection (defined by detectable HCV RNA) and subsequently initiated a new biologic or nonbiologic DMARD...
May 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28242981/hepatitis-c-virus-related-arthritis-bone-scintigraphic-appearances
#11
Gul Ege Aktas, Ali Sarikaya, Ozan Kandemir
A symptomatic joint involvement and arthralgia are frequent in patients with chronic hepatitis C virus (HCV) infection. However, HCV infection-related arthritis (HCVrA) affects up to 4-11% of the subjects suffering from disease. We reported a patient with HCVrA presented with the commonly accepted diagnostic clinical signs and laboratory parameters. The painful joints distinctly demonstrated increased uptake of Tc-99 m methylene diphosphonate in scintigraphy and normal findings in radiography.
January 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28149645/new-insights-into-hcv-related-rheumatologic-disorders-a-review
#12
REVIEW
Patrice Cacoub, Cloé Comarmond
Hepatitis C virus (HCV) infected patients are known to be exposed to major liver complications i.e. cirrhosis and hepatocellular carcinoma. In addition, many extrahepatic manifestations including rheumatologic disorders have been reported in up to two-third of HCV infected patients. These manifestations include frank auto-immune and rheumatic diseases (such as arthralgia, myalgia, arthritis, sicca syndrome and vasculitis) which may dominate the course of infection. Until recently, the standard of care of HCV has been the use of interferon-alpha based regimens, which not only had limited effectiveness in HCV cure but were poorly tolerated...
March 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/27848256/successful-ledipasvir%C3%A2-%C3%A2-sofosbuvir-treatment-of-active-synovitis-in-a-rheumatoid-arthritis-patient-with-hepatitis-c-virus-related-mixed-cryoglobulinemia
#13
Tomohiro Koga, Shin-Ya Kawashiri, Kazuhiko Nakao, Atsushi Kawakami
No abstract text is available yet for this article.
November 23, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27829054/correction-chronic-hepatitis-c-virus-infection-is-associated-with-the-development-of-rheumatoid-arthritis-a-nationwide-population-based-study-in-taiwan
#14
Fu-Hsiung Su, Chien-Sheng Wu, Fung-Chang Sung, Shih-Ni Chang, Chien-Tien Su, Ying-Hua Shieh, Chih-Ching Yeh
[This corrects the article DOI: 10.1371/journal.pone.0113579.].
2016: PloS One
https://www.readbyqxmd.com/read/27686328/value-and-usability-of-unpublished-data-sources-for-systematic-reviews-and-network-meta-analyses
#15
Nicholas James Anthony Halfpenny, Joan Mary Quigley, Juliette Catherine Thompson, David Alexander Scott
Peer-reviewed publications and conference proceedings are the mainstay of data sources for systematic reviews and network meta-analyses (NMA), but access to informative unpublished data is now becoming commonplace. To explore the usefulness of three types of 'grey' literature-clinical trials registries, clinical study reports and data from regulatory authorities-we conducted four case studies. The reporting of outcome data in peer-reviewed publications, the clinical trials registries and the clinical study reports for two clinical trials-one in melanoma, one in juvenile idiopathic arthritis (JIA)-was examined...
September 29, 2016: Evidence-based Medicine
https://www.readbyqxmd.com/read/27639841/the-association-of-other-autoimmune-diseases-in-patients-with-autoimmune-thyroiditis-review-of-the-literature-and-report-of-a-large-series-of-patients
#16
REVIEW
Poupak Fallahi, Silvia Martina Ferrari, Ilaria Ruffilli, Giusy Elia, Marco Biricotti, Roberto Vita, Salvatore Benvenga, Alessandro Antonelli
We have evaluated prospectively the prevalence of other autoimmune disorders in outpatient clinic in 3069 consecutive patients with diagnosed chronic autoimmune thyroiditis (AT), with respect to two age- and sex-matched control groups: a) a control group of 1023 subjects, extracted from a random sample of the general population without thyroid disorders; b) 1023 patients with non-toxic multinodular goiter extracted from the same random sample of the general population, with similar iodine intake. The results of our study demonstrate a significant increase of the prevalence of autoimmune disorders in AT patients (with respect to both controls), for the following diseases: chronic autoimmune gastritis (CAG), vitiligo (Vit), rheumatoid arthritis, polymialgia rheumatica (Polym), celiac disease, diabetes, sjogren disease, multiple sclerosis, systemic lupus erythematosus, sarcoidosis, alopecia, psoriathic arthritis, systemic sclerosis, and HCV-related cryoglobulinemia...
December 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/27522710/-hepatobiliary-system-diseases-as-the-predictors-of-psoriasis-progression
#17
S V Smirnova, A A Barilo, M V Smolnikova
PURPOSE OF THE STUDY: To assess the state of the hepatobiliary system in psoriasis andpsoriatic arthritis in order to establish a causal relationship and to identify clinical and functional predictors of psoriatic disease progression. METHODS: The study includedpatients with extensive psoriasis vulgaris (n = 175) aged 18 to 66 years old and healthy donors (n = 30), matched by sex and age: Group 1--patients with psoriasis (PS, n = 77), group 2--patients with psoriatic arthritis (PsA, n = 98), group 3--control...
2016: Vestnik Rossiĭskoĭ Akademii Meditsinskikh Nauk
https://www.readbyqxmd.com/read/27516667/-gharikon-agharikon-a-valuable-medicinal-mushroom-in-iranian-traditional-medicine
#18
Mehdi Vazirian, Shabnam Faridfar, Mahdieh Eftekhari
BACKGROUND: Gharikon is a well-known medicinal mushroom in Iranian traditional medicine and mentioned several times in different kinds of authentic literature. Considering both traditional and modern literature, the aim of this study is to present a review of its biological activities. METHODS: Using online databases (e.g. PubMed, Scopus, and Google Scholar) as well as reviewing traditional medicinal literature (e.g. Makhzan-ul-Adwiah, Al-Qanun fi al-Tibb); we reviewed the published literature on the pharmacological effects of Laricifomes officinalis (the most common species considered as "Gharikon")...
May 2016: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27515671/the-use-of-cyclosporine-a-in-rheumatology-a-2016-comprehensive-review
#19
REVIEW
Cecilia Beatrice Chighizola, Voon H Ong, Pier Luigi Meroni
Cyclosporine A, an inhibitor of calcineurin, exerts an immunomodulator action interfering with T cell activation. Even though novel therapeutic tools have emerged, CyA still represents a suitable option in several clinical rheumatology settings. This is the case of refractory nephritis and cytopenias associated with systemic lupus erythematosus. Furthermore, CyA is a valued therapeutic tool in the management of uveitis and thrombophlebitis in course of Behçet's disease. Topical CyA has been proven to be beneficial in the dry eye of Sjogren's syndrome, whereas oral treatment with CyA can be considered for the severe complications of adult onset Still's disease...
June 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/27162291/-autoimmune-diseases-with-the-presence-of-anti-ku-antibodies-analysis-of-three-cases
#20
Ewa Wielosz, Maria Majdan, Radosław Jeleniewicz, Marcin Mazurek
a-Ku are rare antibodies, which are reported in course of connective tissue diseases. Their prevalence ranges from 0 to 10% , 2%, on average. The main symptoms associated with the presence of a-Ku antibodies include: myositis, arthritis, Raynaud`s phenomenon and skin lesions. The above features are often defined as autoimmune clinical syndrome associated with a-Ku antibodies. In recent years, three cases with the presence of a-Ku antibodies were observed at the Department of Rheumatology and Connective Tissue Diseases...
2016: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
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