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Skin cosmesis

Caitlin G Robinson, Kory R Lee, Valencia D Thomas
BACKGROUND AND OBJECTIVE: Elephantiasis nostras verrucosa (ENV) is a disfiguring skin condition that is difficult to treat. Existing treatment modalities serve to improve cosmesis or treat symptoms. Herein, we report a case of ENV with lymphocutaneous fistula successfully treated with ablative carbon dioxide laser. STUDY DESIGN/PATIENTS AND METHODS: A 57-year-old woman with biopsy-proven ENV with lymphocutaneous fistula was treated with ablative carbon dioxide laser to the symptomatic area of her right thigh in 3 treatment sessions over 6 months...
March 1, 2018: Journal of Cutaneous Medicine and Surgery
Saul N Rajak, Raman Malhotra, Dinesh Selva
PURPOSE: To describe the 'Over-the-Top' Modified Cutler Beard Procedure (OTTMCB) for complete upper eyelid defect reconstruction Methods: This is retrospective case note review of four patients that underwent the OTTMCB procedure. This two-stage procedure comprises the replacement of the posterior lamella with a free tarsal graft from the contralateral upper eyelid, and the anterior lamella with a lower lid skin flap over the lower eyelid margin which is divided 2-4 weeks later. RESULTS: The procedure was undertaken for four patients with 75-90% upper eyelid defects from tumour excision surgery...
March 7, 2018: Orbit
Budhi Singh Yadav, Suresh C Sharma
PURPOSE: To report the results in terms of feasibility and early toxicity of hypofractionated adjuvant whole breast/chest wall and/or regional nodal radiation therapy for patients with breast cancer. METHODS AND MATERIALS: From June 2013 to October 2014, 50 patients with breast cancer after mastectomy or after breast conservation surgery (BCS) were prospectively included. The institutional ethics committee approved the study, which was registered with ClinicalTrials...
March 15, 2018: International Journal of Radiation Oncology, Biology, Physics
D Quarato, M Pascali, F Carinci
Scars are a very common condition of the general population and can have a profound impact on the psyche of the patient such as low self-esteem and feelings of psychosocial isolation. Various therapeutic approaches have been proposed for improving the clinical appearance of scars. Fractional mode of ablative and non-ablative lasers has become a novel strategy for the treatment of scars. A total of 43 patients (Fitzpatrick skin type II to IV), clinically diagnosed of surgical and post-traumatic scars from January 2015 to December 2016, were treated...
January 2018: Journal of Biological Regulators and Homeostatic Agents
David M Burmeister, Randolph Stone, Nicole Wrice, Alfred Laborde, Sandra C Becerra, Shanmugasundaram Natesan, Robert J Christy
Harvesting of autografts results in donor site morbidities and is limited in scenarios such as large total body surface area burns. In these instances, coverage is increased by meshing grafts at the expense of delayed biologic closure. Moreover, graft meshing increases the likelihood of contraction and hypertrophic scarring, limits range of motion, and worsens cosmesis. Many tissue engineering technologies have touted the promise of adipose-derived stem cells (ASCs) for burn wounds. The primary objective of the current study was to determine feasibility and efficacy of in situ ASC delivery via PEGylated fibrin (FPEG) hydrogels as adjuncts to meshed split thickness skin grafts in a porcine model...
February 18, 2018: Stem Cells Translational Medicine
Yazan N AlJamal, Raaj K Ruparel, Steven R Jacobson, David R Farley
While minimally invasive parathyroidectomy is an advantage to many properly selected patients, longer incisions and even wide skin resection may be optimal in a select few. We present an 80-year-old woman with primary hyperparathyroidism and bothersome excess neck skin and subcutaneous fat. The parathyroid adenoma was easily excised through a vertically-oriented cervical excision that removed an ellipse of fat and skin. Midline wound closure with a small Z-plasty to avoid wound tethering facilitated a cosmetic closure well within the surgical capabilities of endocrine surgeons...
October 2017: Journal of Surgical Case Reports
David Olek, Moataz N El-Ghamry, Niloyjyoti Deb, Nitika Thawani, Courtney Shaver, Subhakar Mutyala
PURPOSE: Nonmelanoma skin cancer is the most commonly diagnosed malignancy in the United States. A modern version of surface brachytherapy, "topographic applicator brachytherapy" (TAB), can be used to treat early-stage nonmelanoma skin cancer (ES-NMSC). The purpose of this study was to evaluate the acute toxicity, chronic toxicity, and recurrence rates of patients with ES-NMSC treated with TAB. METHODS AND MATERIALS: From 2010 to 2013, 172 patients with 273 ES-NMSC tumors were consecutively treated with TAB...
February 1, 2018: Brachytherapy
K J Bernabé, N J Nokoff, D Galan, D Felsen, C E Aston, P Austin, L Baskin, Y-M Chan, E Y Cheng, D A Diamond, R Ellens, A Fried, S Greenfield, T Kolon, B Kropp, Y Lakshmanan, S Meyer, T Meyer, A M Delozier, L L Mullins, B Palmer, A Paradis, P Reddy, K J Scott Reyes, M Schulte, J M Swartz, E Yerkes, C Wolfe-Christensen, A B Wisniewski, D P Poppas
INTRODUCTION: Prior studies of outcomes following genitoplasty have reported high rates of surgical complications among children with atypical genitalia. Few studies have prospectively assessed outcomes after contemporary surgical approaches. OBJECTIVE: The current study reported the occurrence of early postoperative complications and of cosmetic outcomes (as rated by surgeons and parents) at 12 months following contemporary genitoplasty procedures in children born with atypical genitalia...
February 1, 2018: Journal of Pediatric Urology
Daigo Yamamoto, Toshiko Siga, Katsuhiro Yoshikawa, Yu Tsubota, Noriko Sueoka, Tsukuru Chiba, Mariko Ishizuka, Masanori Kon
BACKGROUND: Strut adjusted volume implant(SAVI)was approved by the Food and Drug Administration(FDA)for the treatment of breast cancer in 2006. MATERIAL AND METHODS: The phase II study was conducted to investigate the activity and safety of SAVI in breast cancer patients. Criteria for SAVI treatments were N0, T<2 cm, and age≥40. After patients underwent breast-conserving surgery, they received SAVI twice a day×5 days(34 Gy). The primary endpoint are feasibility and safety...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Ankur Bhatnagar, Vijai Datta Upadhyaya, Basant Kumar, Zafar Neyaz, Ajay Kushwaha
Objectives: Lymphatic malformations (LMs) are aberrant proliferation of sequestrated lymphatic vessels during early embryogenesis and do not communicate directly with the general lymphatic system. The absence of vascular flow is the hallmark of LMs and is usually symptomless apart from painless disfiguring mass with concerns regarding cosmesis. Design: Sclerotherapy has gained prominence as a preferred treatment modality for macrocystic lesions. Here, we present our experience with use of aqueous bleomycin as intralesional sclerosing agent, an economical first-line treatment for macrocystic variant of LMs in children and adults...
July 2017: National Journal of Maxillofacial Surgery
Nicholas G Zaorsky, Charles T Lee, Eddie Zhang, Thomas J Galloway
BACKGROUND AND PURPOSE: To compare cosmesis and local recurrence (LR) of definitive external beam radiation therapy (EBRT) vs brachytherapy (BT) for indolent basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) of the skin. MATERIALS AND METHODS: Studies including patients with T1-2 N0 SCCs/BCCs treated with definitive EBRT/BT and ≥10 months follow-up were analyzed. The primary endpoint was post-treatment cosmesis, categorized as "good," "fair," or "poor...
January 19, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Krishan R Jethwa, Mohamed M Kahila, Kristin C Mara, William S Harmsen, David M Routman, Geralyn M Pumper, Kimberly S Corbin, Jeff A Sloan, Kathryn J Ruddy, Tina J Hieken, Sean S Park, Robert W Mutter
PURPOSE: Accelerated partial breast irradiation (APBI) and whole breast irradiation (WBI) are treatment options for early-stage breast cancer. The purpose of this study was to compare patient-reported-outcomes (PRO) between patients receiving multi-channel intra-cavitary brachytherapy APBI or WBI. METHODS: Between 2012 and 2015, 131 patients with ductal carcinoma in situ (DCIS) or early stage invasive breast cancer were treated with adjuvant APBI (64) or WBI (67) and participated in a PRO questionnaire...
January 18, 2018: Breast Cancer Research and Treatment
Fiorenza De Rose, Antonella Fogliata, Davide Franceschini, Cristina Iftode, Rosalba Torrisi, Giovanna Masci, Andrea Sagona, Corrado Tinterri, Alberto Testori, Wolfgang Gatzemeier, Bethania Fernandes, Daoud Rahal, Luca Cozzi, Armando Santoro, Marta Scorsetti
OBJECTIVE: Hypofractionated radiotherapy in early stage breast cancer is an effective adjuvant treatment, but there is a lack of randomized data for patients with ductal carcinoma in situ (DCIS). Aim of this study is the evaluation of skin toxicity and cosmesis, and early clinical outcome of DCIS patients enrolled in an institutional phase II trial of hypofractionated breast irradiation. METHODS: One hundred thirty-seven DCIS patients were enrolled in the trial...
January 11, 2018: British Journal of Radiology
Jonathan Leventhal, Melissa Rasar Young
Radiation therapy (RT) is a frequently used modality for cancer treatment. Acute and/or chronic skin changes may occur and carry risk of influencing quality of life during and after completion of RT. Radiation reactions may lead to delays in treatment, diminished cosmesis, and functional deficits. Lifestyle factors, treatment modalities, topical agents, and, in some cases, wound dressings may be utilized to help prevent or ameliorate radiation-induced skin reactions. While rigorous evidence supporting specific interventions may be lacking or contradictory, this article summarizes the current knowledge of the etiology, manifestations, and interventions available for prevention and management of radiation dermatitis...
December 15, 2017: Oncology (Williston Park, NY)
Russell J Bramhall, Izaro Hernan, Paul A Harris
INTRODUCTION: Implant-based breast reconstruction has relatively high complication rates. Removal of infected implants and immediate autologous reconstruction is a safe single-stage procedure that preserves the native breast skin envelope. METHODS: A single-centre, retrospective proof-of-concept review of all salvage procedures performed for acute/chronic infected or exposed implant-based reconstructions by a single surgeon over a 6-year period. RESULTS: We present 13 cases of a particularly difficult subgroup of acute/chronic infection/extrusion over a 6-year period...
October 18, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
Furan Wang, Tiejun Shou, Hongji Zhong
INTRODUCTION: Although T-LESS is increasingly being used to treat pediatric inguinal hernia, there is no study regarding T-LESS for pediatric hydrocele. OBJECTIVE: To further evaluate the feasibility of T-LESS and present our single-center experience for repair of pediatric hydroceles. STUDY DESIGN: From January 2016 to July 2016, all boys undergoing T-LESS for hydrocele in our institute were retrospectively reviewed. A laparoscope and a needle-holding forceps were introduced at umbilicus...
October 16, 2017: Journal of Pediatric Urology
Jie Yu, Bao-Hua Chen, Jing Zhang, Zhi-Yu Han, Han Wu, Yan Huang, Meng-Juan Mu, Ping Liang
The benign breast lesions (BBLs) share a high incidence for women and therapy methods with minimal invasion and better cosmetic outcome are thirsted for. In this study, 122 patients with 198 biopsy-proved BBLs were enrolled. Ultrasound (US)-guided microwave ablation (MWA) was performed with local anesthesia from November, 2013 to April, 2016. The mean longest tumor size assessed was 1.6±0.7 cm (ranging 0.7-4.9 cm). MWA was successfully performed in all cases including 85 lesions adjacent to the skin, pectoralis and areola...
October 3, 2017: Oncotarget
Suzanne M Watt, Jonathan M Pleat
The importance of skin to survival, and the devastating physical and psychological consequences of scarring following reparative healing of extensive or difficult to heal human wounds, cannot be disputed. We discuss the significant challenges faced by patients and healthcare providers alike in treating these wounds. New state of the art technologies have provided remarkable insights into the role of skin stem and progenitor cells and their niches in maintaining skin homeostasis and in reparative wound healing...
October 26, 2017: Advanced Drug Delivery Reviews
Tulin D Cil, David McCready
The armamentarium of the modern breast surgeon includes the time-tested procedures of modified radical mastectomy and lumpectomy with sentinel lymph node biopsy with postoperative radiation, but has evolved to include several options that produce excellent oncologic endpoints and improved cosmesis. These options include skin- and nipple-sparing mastectomies with immediate reconstruction as well as oncoplastic procedures that allow larger excisions and better postoperative breast shape. This article provides an overview of these modern surgical approaches for breast cancer treatment...
January 2018: Clinics in Plastic Surgery
Demetri Arnaoutakis, Sameep Kadakia, Manoj Abraham, Thomas Lee, Yadranko Ducic
The goals of reconstruction following any oncologic extirpation are preservation of function, restoration of cosmesis, and avoidance of morbidity. Anatomically, the lateral skull base is complex and conceptually intricate due to its three-dimensional morphology. The temporal bone articulates with five other cranial bones and forms many sutures and foramina through which pass critical neural and vascular structures. Remnant defects following resection of lateral skull base tumors are often not amenable to primary closure...
November 2017: Seminars in Plastic Surgery
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