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https://www.readbyqxmd.com/read/28454115/impact-of-marital-status-during-diagnosis-on-cancer-caused-specific-survival-in-acute-myeloid-leukemia-patients-a-case-control-and-population-based-study
#1
Zhuojun Zheng, Yuandong Zhu, Xiaodong Li, Wenwei Hu, Jingting Jiang
OBJECTIVE: This study investigated the impact of marital status on cancer-caused specific mortality among acute myeloid leukemia (AML) patients in the United States. METHODS: We used the Surveillance, Epidemiology and End Results program to identify 50,825 patients who had their clinical and follow-up information available and were diagnosed for AML between the years 1988 and 2015. The univariate and multivariable Cox regression models were used to analyze the patient data, and to minimize the group differences due to covariates between groups, a 1:1 propensity score matching was used in subsequent subgroup analysis...
April 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28454083/comparison-of-long-term-outcome-between-hemicolectomy-and-partial-colectomy-in-the-elderly-a-large-population-based-study
#2
Xu Guan, Hanqing Hu, Wei Chen, Zheng Jiang, Zheng Liu, Zhixun Zhao, Yinggang Chen, Guiyu Wang, Xishan Wang
Due to large progress has been achieved in surgical techniques, anesthesia and perioperative care, it is accepted that the very elderly colon cancer (CC) patient is not contraindication for surgery. However, it is a controversy that an extended or a less aggressive surgical approach should be performed for this population. Here, we identified 28110 CC patients aged ≥80 from Surveillance, Epidemiology, and End-Results (SEER) database. The surgical approaches included extended hemicolectomy (HC) and partial colectomy (PC)...
April 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28453972/exposure-to-ambient-pm2-5-associated-with-overall-and-domain-specific-disability-among-adults-in-six-low-and-middle-income-countries
#3
Hualiang Lin, Yanfei Guo, Yang Zheng, Xing Zhao, Zheng Cao, Steven E Rigdon, Hong Xian, Xing Li, Tao Liu, Jianpeng Xiao, Weilin Zeng, Nancy L Weaver, ZhengminMin Qian, Wenjun Ma, Fan Wu
BACKGROUND: Exposure to particulate matter pollution is associated with various cardiopulmonary diseases, which are closely related with disability. The direct relationship between air pollution and disability, however, has not been fully explored. METHODS: We used data from 45,625 participants in the Study on global AGEing and adult health in six low- and middle-income countries. The 12-item version of the World Health Organization Disability Assessment Schedule (WHODAS 2...
April 25, 2017: Environment International
https://www.readbyqxmd.com/read/28453875/persistent-depression-symptoms-in-type-2-diabetes-risk-factors-and-outcomes-of-5-year-depression-trajectories-using-latent-class-growth-analysis
#4
S R Whitworth, D G Bruce, S E Starkstein, W A Davis, T M E Davis, T C Skinner, R S Bucks
AIMS: To describe the long-term trajectories of depression symptom severity in people with Type 2 diabetes, and to identify predictors and associates of these trajectories. METHODS: A community-dwelling cohort of 1201 individuals with Type 2 diabetes from the Fremantle Diabetes Study Phase II was followed for 5 years. The nine-item version of the Patient Health Questionnaire was administered annually to assess depression symptoms, and biomedical and psychosocial measures were assessed at baseline and biennially...
April 28, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28453826/unplanned-readmissions-within-30-days-after-discharge-improving-quality-through-easy-prediction
#5
Francesca Casalini, Susanna Salvetti, Silvia Memmini, Elena Lucaccini, Gabriele Massimetti, Pier Luigi Lopalco, Gaetano Pierpaolo Privitera
Objective: To propose an easy predictive model for the risk of rehospitalization, built from hospital administrative data, in order to prevent repeated admissions and to improve transitional care. Design: Retrospective cohort study. Setting: Azienda Ospedaliero Universitaria Pisana (Pisa University Hospital). Participants: Patients residing in the territory of the province of Pisa (Tuscany Region) with at least one unplanned hospital admission leading to a medical Diagnosis-Related Group (DRG) in the calendar year 2012...
April 1, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28453820/reliability-of-clinical-impact-grading-by-healthcare-professionals-of-common-prescribing-error-and-optimisation-cases-in-critical-care-patients
#6
Richard S Bourne, Rob Shulman, Mark Tomlin, Mark Borthwick, Will Berry, Gary H Mills
Objective: To identify between and within profession-rater reliability of clinical impact grading for common critical care prescribing error and optimisation cases. To identify representative clinical impact grades for each individual case. Design: Electronic questionnaire. Setting: 5 UK NHS Trusts. Participants: 30 Critical care healthcare professionals (doctors, pharmacists and nurses). Intervention: Participants graded severity of clinical impact (5-point categorical scale) of 50 error and 55 optimisation cases...
April 1, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28453762/estimates-of-disease-course-in-inflammatory-bowel-disease-using-administrative-data-a-population-level-study
#7
Dessalegn Y Melesse, Lisa M Lix, Zoann Nugent, Laura E Targownik, Harminder Singh, James F Blanchard, Charles N Bernstein
Background and Aims: We sought develop a predictive model of disease course in inflammatory bowel disease [IBD] using health care utilization measures from administrative health data, and to apply this model to estimate disease course at a population level over time. Methods: Study participants were IBD patients who were prospectively followed for a 1-year period between 2009 and 2010 in a Canadian clinic setting to assess their IBD disease course [i.e. remission, mild, moderate, severe]...
May 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28453749/an-independently-validated-nomogram-for-individualized-estimation-of-survival-among-patients-with-newly-diagnosed-glioblastoma-nrg-oncology-rtog-0525-and-0825
#8
Haley Gittleman, Daniel Lim, Michael W Kattan, Arnab Chakravarti, Mark R Gilbert, Andrew B Lassman, Simon S Lo, Mitchell Machtay, Andrew E Sloan, Erik P Sulman, Devin Tian, Michael A Vogelbaum, Tony J C Wang, Marta Penas-Prado, Emad Youssef, Deborah T Blumenthal, Peixin Zhang, Minesh P Mehta, Jill S Barnholtz-Sloan
Background.: Glioblastoma (GBM) is the most common primary malignant brain tumor. Nomograms are often used for individualized estimation of prognosis. This study aimed to build and independently validate a nomogram to estimate individualized survival probabilities for patients with newly diagnosed GBM, using data from 2 independent NRG Oncology Radiation Therapy Oncology Group (RTOG) clinical trials. Methods.: This analysis included information on 799 (RTOG 0525) and 555 (RTOG 0825) eligible and randomized patients with newly diagnosed GBM and contained the following variables: age at diagnosis, race, gender, Karnofsky performance status (KPS), extent of resection, O6-methylguanine-DNA methyltransferase (MGMT) methylation status, and survival (in months)...
May 1, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28453720/-seeking-affluent-neighbourhoods-a-time-trend-analysis-of-geographical-distribution-of-hospitals-in-the-megacity-of-tehran
#9
Yousef Chavehpour, Arash Rashidian, Hossein Raghfar, Sara Emamgholipour Sefiddashti, Aiub Maroofi
Objective: Access to hospitals in megacities in low and middle income countries might be hampered by travel barriers and distance. We assessed the 'inverse care law' hypothesis: whether hospitals tended to be built in the relatively better-off areas through the time. Methods: A longitudinal time-series study (1966 to 2011) in Tehran to measure inequality in the distribution of hospital beds. We assessed correlations between the district socioeconomic status and availability of hospital beds via regression analyses, estimated correlation, Gini and concentration indices, and used GIS models to map hospital distributions through time...
June 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28453645/medicare-part-d-payments-for-topical-steroids-rising-costs-and-potential-savings
#10
Hannah Song, Adewole Adamson, Arash Mostaghimi
Importance: Rising pharmaceutical costs in the United States are an increasing source of financial burden for payers and patients. Although topical steroids are among the most commonly prescribed medications in dermatology, there are limited data on steroid-related spending and utilization. Objective: To characterize Medicare and patient out-of-pocket costs for topical steroids, and to model potential savings that could result from substitution of the cheapest topical steroid from the corresponding potency class...
April 28, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28453639/perioperative-morbidity-and-mortality-of-octogenarians-treated-by-radical-cystectomy-a-multi-institutional-retrospective-study-in-japan
#11
Takashige Abe, Norikata Takada, Hiroshi Kikuchi, Ryuji Matsumoto, Takahiro Osawa, Sachiyo Murai, Naoto Miyajima, Satoru Maruyama, Nobuo Shinohara
Objective: To determine the characteristics of 90-day morbidity and mortality after radical cystectomy in Japanese octogenarians. Methods: A retrospective multi-institutional study. We reviewed the records of 834 patients treated by open radical cystectomy between 1997 and 2010. All complications within 90 days after surgery were sorted into the 11 categories proposed by the Memorial Sloan-Kettering Cancer Center and graded according to the modified Clavien-Dindo system...
April 27, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28453562/associations-of-women-s-position-in-the-household-and-food-insecurity-with-family-planning-use-in-nepal
#12
Nadia Diamond-Smith, Anita Raj, Ndola Prata, Sheri D Weiser
BACKGROUND: Women in Nepal have low status, especially younger women in co-resident households. Nepal also faces high levels of household food insecurity and malnutrition, and stagnation in uptake of modern family planning methods. OBJECTIVE: This study aims to understand if household structure and food insecurity interact to influence family planning use in Nepal. METHODS: Using data on married, non-pregnant women aged 15-49 with at least one child from the Nepal 2011 Demographic and Health Survey (N = 7,460), we explore the relationship between women's position in the household, food insecurity as a moderator, and family planning use, using multi-variable logistic regressions...
2017: PloS One
https://www.readbyqxmd.com/read/28453370/school-absence-and-productivity-outcomes-associated-with-childhood-asthma-in-the-usa
#13
Patrick Sullivan, Vahram G Ghushchyan, Prakash Navaratnam, Howard S Friedman, Abhisek Kavati, Benjamin Ortiz, Bob Lanier
BACKGROUND: Previous studies have examined the association between childhood asthma and lost productivity; however, more data are needed to understand its impact. METHODS: This was a retrospective analysis of cross-sectional data in the nationally representative 2007-2013 Medical Expenditure Panel Survey (MEPS). School-aged children (SAC), children (age 6-11), and adolescents (age 12-17) with asthma were compared to those without asthma to examine annual missed school days...
April 28, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28449529/do-hospitals-need-oncological-critical-care-units
#14
EDITORIAL
Abby Koch, William Checkley
Since the inception of critical care as a formal discipline in the late 1950s, we have seen rapid specialization to many types of intensive care units (ICUs) to accommodate evolving life support technologies and novel therapies in various disciplines of medicine. Indeed, the field has expanded such that specialized ICUs currently exist to address critical care problems in medicine, cardiology, neurology and neurosurgery, trauma, burns, organ transplant and cardiothoracic surgeries. Specialization does not only need new infrastructure, but also training and staffing of health care providers, ancillary staff, and development and implementation of processes of care...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28449343/cost-effectiveness-of-the-highly-effective-direct-acting-antivirals-in-the-treatment-of-chronic-hepatitis-c-in-hong-kong
#15
Angeline Oi-Shan Lo, Henry Lik-Yuen Chan, Vincent Wai-Sun Wong, Grace Lai-Hung Wong
BACKGROUND AND AIM: In Asia-Pacific where cost is a major concern, peginterferon plus ribavirin (PR) often remain as the standard of care in chronic hepatitis C (CHC) treatment, while the direct-acting antivirals (DAAs) are commonly recommended as retreatment. Newer DAAs can achieve a sustained virological response (SVR) of nearly 100% with pan-genotypic coverage, that is "Highly Effective DAAs." We aimed to investigate the most desirable cost range for the Highly Effective DAAs using Hong Kong as an example...
May 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28449205/impact-of-pharmacist-involved-collaborative-care-on-the-clinical-humanistic-and-cost-outcomes-of-high-risk-patients-with-type-2-diabetes-impact-a-randomized-controlled-trial
#16
M Y L Siaw, Y Ko, D C Malone, K Y K Tsou, Y-J Lew, D Foo, E Tan, S C Chan, A Chia, S S Sinaram, K C Goh, J Y-C Lee
WHAT IS KNOWN AND OBJECTIVE: With the increasing prevalence of diabetes, the physician-centred model is challenged to deliver holistic care in Asia. Diabetes may be managed effectively within a multidisciplinary collaborative care model; however, evidence on its effectiveness in Asian patients is lacking. Therefore, the primary objective was to evaluate the clinical outcomes of multidisciplinary collaborative care vs physician-centred care in diabetes. The secondary objectives were to evaluate humanistic and economic outcomes among the two types of care...
April 27, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28449113/development-of-a-new-clinical-severity-staging-system-for-patients-with-nonmetastatic-papillary-thyroid-carcinoma
#17
Omar A Karadaghy, Dorina Kallogjeri, Jay F Piccirillo
Importance: The inclusion of patient features in addition to tumor morphology provides a more holistic staging system. Objective: To identify prognostically important variables in papillary thyroid carcinoma (PTC) to incorporate into a comprehensive functional severity staging system (FSSS) and clinical severity staging system (CSSS) and to validate the model using a multi-institutional database. Design, Setting, and Participants: Retrospective cohort study of adults 18 years or older newly diagnosed or treated for nonmetastatic PTC at the Siteman Cancer Center from 1995 through 2012...
April 27, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28449111/migrant-women-living-with-hiv-in-europe-are-they-facing-inequalities-in-the-prevention-of-mother-to-child-transmission-of-hiv-the-european-pregnancy-and-paediatric-hiv-cohort-collaboration-eppicc-study-group-in-eurocoord
#18
G Favarato, H Bailey, F Burns, L Prieto, A Soriano-Arandes, C Thorne
In pregnancy early interventions are recommended for prevention of mother-to-child-transmission (PMTCT) of HIV. We examined whether pregnant women who live with HIV in Europe and are migrants encounter barriers in accessing HIV testing and care. Four cohorts within the European Pregnancy and Paediatric HIV Cohort Collaboration provided data for pooled analysis of 11 795 pregnant women who delivered in 2002-12 across ten European countries. We defined a migrant as a woman delivering in a country different from her country of birth and grouped the countries into seven world regions...
April 25, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28449107/the-role-of-dyadic-confidence-on-engagement-in-heart-failure-care-behaviors
#19
Karen S Lyons, Jill M Gelow, Shirin O Hiatt, James O Mudd, Jonathan Auld, Christopher V Chien, Christopher S Lee
Background and Objectives: Increasingly, older adults and their families are expected to manage complex conditions with little support. In the case of heart failure (HF), symptom monitoring and management are critical in preventing acute exacerbations and poor clinical outcomes. The current study examined the role of dyadic confidence on engagement in HF care behaviors by patients and their spouses. Research Design and Methods: A cross-sectional design was used to examine 60 couples living with HF...
April 26, 2017: Gerontologist
https://www.readbyqxmd.com/read/28448903/violence-trauma-and-living-with-hiv-longitudinal-predictors-of-initiating-crystal-methamphetamine-injection-among-sex-workers
#20
Elena Argento, Steffanie A Strathdee, Shira Goldenberg, Melissa Braschel, Julio Montaner, Kate Shannon
BACKGROUND: Despite rapid increases in crystal methamphetamine (CM) use worldwide and established gendered patterns of use, empirical research on CM injection initiation among sex workers is limited. Given the wide range of harms associated with CM, alongside stimulant effects including sexual dis-inhibition and prolonged awake-ness, this study aimed to longitudinally investigate socio-structural predictors of initiating CM injection among sex workers in Vancouver, Canada. METHODS: Data (2010-2014) were drawn from a community-based cohort of women sex workers: AESHA (An Evaluation of Sex Workers Health Access)...
April 19, 2017: Drug and Alcohol Dependence
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