keyword
MENU ▼
Read by QxMD icon Read
search

CSVD

keyword
https://www.readbyqxmd.com/read/27874975/structural-and-functional-brain-alterations-in-a-murine-model-of-angiotensin-ii-induced-hypertension
#1
Anja Meissner, Jens Minnerup, Guadalupe Soria Rodriguez, Anna M Planas
Hypertension is a main risk factor for the development of cerebral small vessel disease (cSVD) - a major contributor to stroke and the most common cause of vascular dementia. Despite the increasing socio-economic importance arising from cSVD, currently only a few specific treatment strategies with proven efficacy are known. Fundamental to the lack of specific treatments is poor understanding of the disease pathogenesis and a lack of appropriate animal models resembling all symptoms of the human disease. However, chronic hypertensive rat models have been shown to bear similarities to most key features of cSVD...
November 22, 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27754237/os-34-04-safety-of-early-intensive-blood-pressure-lowering-in-cerebral-small-vessel-disease-and-chronic-kidney-disease-in-acute-intracerebral-hemorrhage
#2
Craig Anderson, Shoichiro Sato, Candice Delcourt, Hisatomi Arima, Shihong Zhang, Rustam RAl-Shahi Salman, Christian Stapf, Dan Woo, Matthew Flaherty, Achala Vagal, Jiguang Wang, John Chalmers
OBJECTIVE: The INTERACT2 trial demonstrated beneficial effects of early intensive blood pressure (BP) lowering in intracerebral hemorrhage (ICH). However, concerns persist over harms associated with the treatment, particularly in patients with cerebral small vessel disease (CSVD) (ie white matter lesions [WML], lacunes and atrophy) and renal failure. We determined associations of CSVD, and renal failure, on outcomes in INTERACT2 participants. DESIGN AND METHOD: There were 2069/2839 patients with baseline brain CT (< 6hr ICH onset)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27727072/association-between-serum-cystatin-c-level-and-total-magnetic-resonance-imaging-burden-of-cerebral-small-vessel-disease-in-patients-with-acute-lacunar-stroke
#3
Song Yang, Jing Cai, Rulan Lu, Jian Wu, Min Zhang, Xianju Zhou
OBJECTIVE: Chronic kidney disease (CKD) is associated with cerebral small vessel disease (cSVD). However, the relationship between serum cystatin C (CysC) level, a highly sensitive marker of impaired kidney function, and cSVD has not been fully understood. This study aimed to investigate the association between serum CysC level and total burden of cSVD on magnetic resonance imaging (MRI) in patients with acute lacunar stroke. MATERIALS AND METHODS: A total of 210 patients with first-ever acute lacunar stroke occurring within 1 week after onset were included in this study...
October 7, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27689914/can-neuroimaging-markers-of-vascular-pathology-explain-cognitive-performance-in-adults-with-sickle-cell-anemia-a-review-of-the-literature
#4
Dana R Jorgensen, Caterina Rosano, Enrico M Novelli
Adults with homozygous sickle cell anemia have, on average, lower cognitive function than unaffected controls. The mechanisms underlying cognitive deterioration in this population are poorly understood, but cerebral small vessel disease (CSVD) is likely to be implicated. We conducted a systematic review using the Prisma Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines of articles that included both measures of cognitive function and magnetic resonance imaging (MRI) neuroimaging markers of small vessel disease...
September 30, 2016: Hemoglobin
https://www.readbyqxmd.com/read/27666438/disruption-of-a-mir-29-binding-site-leading-to-col4a1-upregulation-causes-pontine-autosomal-dominant-microangiopathy-with-leukoencephalopathy
#5
Edgard Verdura, Dominique Hervé, Françoise Bergametti, Clémence Jacquet, Typhaine Morvan, Carol Prieto-Morin, Alexandre Mackowiak, Eric Manchon, Hassan Hosseini, Charlotte Cordonnier, Isabelle Girard-Buttaz, Sophie Rosenstingl, Christian Hagel, Gregor Kuhlenbaümer, Elena Leca-Radu, Didier Goux, Lauren Fleming, Tom Van Agtmael, Hugues Chabriat, Françoise Chapon, Elisabeth Tournier-Lasserve
OBJECTIVE: Cerebral small vessel disease (cSVD) is a heterogeneous group of disorders. Screening of known cSVD genes identifies the causative mutation in <15% of familial cSVD cases. We sought to identify novel causes of cSVD. METHODS: We used linkage analysis and exome sequencing to identify the causal mutation in a French cSVD family. The identified candidate gene was then screened in 202 cSVD unrelated probands, including 1 proband from the first reported pontine autosomal dominant microangiopathy with leukoencephalopathy (PADMAL) family...
September 26, 2016: Annals of Neurology
https://www.readbyqxmd.com/read/27662299/white-matter-hyperintensities-potentiate-hippocampal-volume-reduction-in-non-demented-older-individuals-with-abnormal-amyloid-%C3%AE
#6
Whitney M Freeze, Heidi I L Jacobs, Ed H Gronenschild, Jacobus F A Jansen, Saartje Burgmans, Pauline Aalten, Lies Clerx, Stephanie J Vos, Mark A van Buchem, Frederik Barkhof, Wiesje M van der Flier, Marcel M Verbeek, Marcel Olde Rikkert, Walter H Backes, Frans R Verhey
Cerebral small vessel disease (cSVD) and amyloid-β (Aβ) deposition often co-exist in (prodromal) dementia, and both types of pathology have been associated with neurodegeneration. We examined whether cSVD and Aβ have independent or interactive effects on hippocampal volume (HV) in a memory clinic population. We included 87 individuals with clinical diagnoses of Alzheimer's disease (AD) (n = 24), mild cognitive impairment (MCI) (n = 26), and subjective cognitive complaints (SCC) (n = 37). cSVD magnetic resonance imaging markers included white matter hyperintensity (WMH) volume, lacunar infarct presence, and microbleed presence...
November 1, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27643197/os-34-04-safety-of-early-intensive-blood-pressure-lowering-in-cerebral-small-vessel-disease-and-chronic-kidney-disease-in-acute-intracerebral-hemorrhage
#7
Craig Anderson, Shoichiro Sato, Candice Delcourt, Hisatomi Arima, Shihong Zhang, Rustam RAl-Shahi Salman, Christian Stapf, Dan Woo, Matthew Flaherty, Achala Vagal, Jiguang Wang, John Chalmers
OBJECTIVE: The INTERACT2 trial demonstrated beneficial effects of early intensive blood pressure (BP) lowering in intracerebral hemorrhage (ICH). However, concerns persist over harms associated with the treatment, particularly in patients with cerebral small vessel disease (CSVD) (ie white matter lesions [WML], lacunes and atrophy) and renal failure. We determined associations of CSVD, and renal failure, on outcomes in INTERACT2 participants. DESIGN AND METHOD: There were 2069/2839 patients with baseline brain CT (< 6hr ICH onset)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27350079/cilostazol-reduces-blood-brain-barrier-dysfunction-white-matter-lesion-formation-and-motor-deficits-following-chronic-cerebral-hypoperfusion
#8
Hamidreza Edrissi, Sarah C Schock, Robert Cadonic, Antoine M Hakim, Charlie S Thompson
Cerebral small vessel disease (CSVD) is a pathological process leading to lacunar infarcts, leukoaraiosis and cerebral microbleeds. Dysfunction of the blood brain barrier (BBB) has been proposed as a mechanism in the progression cerebral small vessel disease. A rodent model commonly used to study some aspects of CSVD is bilateral common carotid artery occlusion (BCCAO) in the rat. In the present study it was determined that gait impairment, as determined by a tapered beam test, and BBB permeability increased following BCCAO...
September 1, 2016: Brain Research
https://www.readbyqxmd.com/read/27318142/cerebral-microbleeds-are-associated-with-physical-frailty-a-community-based-study
#9
Chih-Ping Chung, Kun-Hsien Chou, Wei-Ta Chen, Li-Kuo Liu, Wei-Ju Lee, Liang-Kung Chen, Ching-Po Lin, Pei-Ning Wang
The present study aimed to evaluate whether cerebral microbleeds (CMBs), as a presentation of cerebral small vessel diseases (CSVDs), are associated with physical frailty. This is a cross-sectional evaluation in participants from a community-based study, the I-Lan Longitudinal Aging Study. The physical frail status was evaluated using the Cardiovascular Health Study score, which includes components of weakness, low physical activity, slowness, exhaustion, and weight loss. The CMBs were assessed with magnetic resonance imaging using susceptibility-weighted imaging...
August 2016: Neurobiology of Aging
https://www.readbyqxmd.com/read/27173592/hypertension-and-the-brain-a-risk-factor-for-more-than-heart-disease
#10
Anja Meissner
BACKGROUND: Cerebral small vessel disease (cSVD), a common risk factor for cognitive impairment, involves unspecific arteriopathy characterized by hypertrophy and endothelial dysfunction that alter cerebrovascular function and auto-regulation of cerebral blood flow (CBF). Microbleedings, subcortical lacunar infarctions and diffuse areas of white matter lesions resulting from vascular injury are associated with reduced cognitive function mostly characterized by difficulties in learning and retention, attention deficits, gait disorders or depression...
2016: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/27155239/agrobacterium-mediated-inoculation-of-chrysanthemum-chrysanthemum-morifolium-plants-with-chrysanthemum-stunt-viroid
#11
Tomoyuki Nabeshima, Motoaki Doi, Munetaka Hosokawa
Agroinfiltration was tested as a method of inoculation of chrysanthemum plants with chrysanthemum stunt viroid (CSVd). Binary vectors harboring dimeric CSVd sequences in sense and antisense orientations were constructed, and Agrobacterium transfected with these binary vectors was infiltrated into chrysanthemum leaves. Northern blotting and reverse transcription polymerase chain reaction analysis showed that local infection was established within 7 days and systemic infection within 20 days. CSVd polarities showed no difference in infectivity...
August 2016: Journal of Virological Methods
https://www.readbyqxmd.com/read/27151686/age-related-hypoxia-in-cns-pathology
#12
George Mihai Bădescu, Mădălina Fîlfan, Ovidiu Ciobanu, DănuŢ Adrian Dumbravă, Aurel Popa-Wagner
Although neuropathological conditions differ in the etiology of the inflammatory response, cellular and molecular mechanisms of neuroinflammation are probably similar in aging, hypertension, depression and cognitive impairment. Moreover, a number of common risk factors such as obesity, hypertension, diabetes and atherosclerosis are increasingly understood to act as "silent contributors" to neuroinflammation and can underlie the development of disorders such as cerebral small vessel disease (cSVD) and subsequent dementia...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27119011/lower-serum-caveolin-1-is-associated-with-cerebral-microbleeds-in-patients-with-acute-ischemic-stroke
#13
Jun Zhang, Wusheng Zhu, Lulu Xiao, Qinqin Cao, Hao Zhang, Huaiming Wang, Zusen Ye, Yonggang Hao, Qiliang Dai, Wen Sun, Yunyun Xiong, Xinfeng Liu, Ruidong Ye, Gelin Xu
Caveolin-1 (Cav-1) plays pivotal roles in the endothelial damage following stroke. The present study aimed to investigate whether serum Cav-1 level is associated with the presence of cerebral small vessel disease (cSVD) in patients with acute ischemic stroke. To this end, 156 patients were consecutively enrolled. Cranial magnetic resonance imaging was analyzed to determine the surrogates of cSVD, including cerebral microbleeds (CMBs), silent lacunar infarcts (SLIs), and white matter hyperintensities (WMHs)...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27053224/digestion-of-chrysanthemum-stunt-viroid-by-leaf-extracts-of-capsicum-chinense-indicates-strong-rna-digesting-activity
#14
Boubourakas Iraklis, Hiroko Kanda, Tomoyuki Nabeshima, Mayu Onda, Nao Ota, Sota Koeda, Munetaka Hosokawa
CSVd could not infect Nicotiana benthamiana when the plants were pretreated with crude leaf extract of Capsicum chinense 'Sy-2'. C. chinense leaves were revealed to contain strong RNA-digesting activity. Several studies have identified active antiviral and antiviroid agents in plants. Capsicum plants are known to contain antiviral agents, but the mechanism of their activity has not been determined. We aimed to elucidate the mechanism of Capsicum extract's antiviroid activity. Chrysanthemum stunt viroid (CSVd) was inoculated into Nicotiana benthamiana plants before or after treating the plants with a leaf extract of Capsicum chinense 'Sy-2'...
August 2016: Plant Cell Reports
https://www.readbyqxmd.com/read/27031692/microalbuminuria-and-the-combination-of-mri-markers-of-cerebral-small-vessel-disease
#15
Andrea Vilar-Bergua, Iolanda Riba-Llena, Natalia Ramos, Xavier Mundet, Eugenia Espinel, Antonio López-Rueda, Elena Ostos, Daniel Seron, Joan Montaner, Pilar Delgado
BACKGROUND: Kidney function has been related to the presence of individual markers of cerebral small vessel disease (CSVD), as lacunes, white matter hyperintensities (WMH) or microbleeds. We aimed at studying the relationship of kidney dysfunction with the combination of several markers of CSVD. METHODS: Subjects are those included in the ISSYS cohort (Investigating Silent Strokes in hypertensives: a magnetic resonance imaging study). A scale ranging from 0 to 4 points was applied based on the presence (one point each) of lacunes, deep microbleeds, moderate to extensive basal ganglia enlarged perivascular spaces (EPVS), and periventricular or deep WMH...
2016: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/26973607/low-temperature-treatment-affects-concentration-and-distribution-of-chrysanthemum-stunt-viroid-in-argyranthemum
#16
Zhibo Zhang, YeonKyeong Lee, Astrid Sivertsen, Gry Skjeseth, Sissel Haugslien, Jihong Liu Clarke, Qiao-Chun Wang, Dag-Ragnar Blystad
Chrysanthemum stunt viroid (CSVd) can infect Argyranthemum and cause serious economic loss. Low temperature treatment combined with meristem culture has been applied to eradicate viroids from their hosts, but without success in eliminating CSVd from diseased Argyranthemum. The objectives of this work were to investigate (1) the effect of low temperature treatment combined with meristem culture on elimination of CSVd, (2) the effect of low temperature treatment on CSVd distribution pattern in shoot apical meristem (SAM), and (3) CSVd distribution in flowers and stems of two infected Argyranthemum cultivars...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/26969256/homocysteinemia-control-by-cysteine-in-cerebral-vascular-patients-after-methionine-loading-test-evidences-in-physiological-and-pathological-conditions-in-cerebro-vascular-and-multiple-sclerosis-patients
#17
Monica Ulivelli, Raffaella Priora, Danila Di Giuseppe, Lucia Coppo, Domenico Summa, Antonios Margaritis, Simona Frosali, Sabina Bartalini, Giuseppe Martini, Alfonso Cerase, Paolo Di Simplicio
The toxicity risk of hyperhomocysteinemia is prevented through thiol drug administration which reduces plasma total homocysteine (tHcy) concentrations by activating thiol exchange reactions. Assuming that cysteine (Cys) is a homocysteinemia regulator, the hypothesis was verified in healthy and pathological individuals after the methionine loading test (MLT). The plasma variations of redox species of Cys, Hcy, cysteinylglycine, glutathione and albumin (reduced, HS-ALB, and at mixed disulfide, XSS-ALB) were compared in patients with cerebral small vessels disease (CSVD) (n = 11), multiple sclerosis (MS) (n = 12) and healthy controls (n = 11) at 2-4-6 h after MLT...
June 2016: Amino Acids
https://www.readbyqxmd.com/read/26935893/gray-and-white-matter-changes-linking-cerebral-small-vessel-disease-to-gait-disturbances
#18
Yeo Jin Kim, Hun Ki Kwon, Jong Min Lee, Hanna Cho, Hee Jin Kim, Hee Kyung Park, Na-Yeon Jung, Jin San Lee, Juyoun Lee, Young Kyoung Jang, Sung Tae Kim, Kyung Han Lee, Yearn Seong Choe, Yun Joong Kim, Duk L Na, Sang Won Seo
OBJECTIVE: To investigate the topographic changes of white matter (WM) integrity and cortical thickness related to gait disturbances and determine whether these neural correlates mediate the association between cerebral small vessel disease (CSVD) and gait disturbances. METHODS: A total of 129 patients with subcortical vascular cognitive impairment were included. CSVD severity was quantified as global and regional WM hyperintensities (WMH) volume and lacune and microbleed numbers...
March 29, 2016: Neurology
https://www.readbyqxmd.com/read/26923464/pathoconnectomics-of-cognitive-impairment-in-small-vessel-disease-a%C3%A2-systematic-review
#19
REVIEW
Ayan K Dey, Vessela Stamenova, Gary Turner, Sandra E Black, Brian Levine
INTRODUCTION: Cerebral small vessel disease (CSVD) is a highly prevalent condition associated with diffuse ischemic damage and cognitive dysfunction particularly in executive function and attention. Functional brain imaging studies can reveal mechanisms of cognitive impairment in CSVD, although findings are mixed. METHODS: A systematic review integrating findings from functional magnetic resonance imaging and electroencephalography in CSVD is involved. RESULTS: CSVD damages long-range white matter tracts connecting nodes within distributed brain networks...
July 2016: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/26774868/association-between-low-estimated-glomerular-filtration-rate-and-risk-of-cerebral-small-vessel-diseases-a-meta-analysis
#20
Yuanyuan Liu, Pu Lv, Haiqiang Jin, Wei Cui, Chenguang Niu, Mingming Zhao, Chenghe Fan, Yuming Teng, Bing Pan, Qing Peng, Jingjing Luo, Lemin Zheng, Yining Huang
BACKGROUND: Although chronic kidney disease has been linked to cerebral small-vessel disease (CSVD), a definite relationship between them has not been established. This study assessed whether low estimated glomerular filtration is associated with risk of different subtypes of CSVDs. METHODS: Electronic databases were systematically searched for studies reporting an odds ratio of the association between low estimated glomerular filtration and CSVD risk. Sixteen studies, including 10,534 participants, were identified...
March 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
keyword
keyword
35973
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"