keyword
https://read.qxmd.com/read/38532286/paediatric-aortic-valve-replacement-using-decellularized-allografts-a-multi-centre-update-following-143-implantations-and-5-year-mean-follow-up
#1
JOURNAL ARTICLE
Alexander Horke, Dmitry Bobylev, Murat Avsar, Tomislav Cvitkovic, Bart Meyns, Filip Rega, Mark Hazekamp, Robert Cesnjevar, Martin Schmiady, Brigitte Staebler, Oliver Dewald, Anatol Ciubotaru, Ina Michel-Behnke, Daniel Zimpfer, Ramadan Jashari, Dietmar Boethig, Serghei Cebotari, Philipp Beerbaum, Igor Tudorache, Samir Sarikouch
OBJECTIVES: Decellularized aortic homografts (DAH) were introduced in 2008 as a further option for paediatric aortic valve replacement (AVR). METHODS: Prospective, multicentre follow-up of all paediatric patients receiving DAH for AVR in 8 European centres. RESULTS: 143 DAH were implanted between 2/2008 and 2/2023 in 137 children (106 male, 74%) with a median age of 10.8 years (IQR 6.6-14.6). 84 (59%) had undergone previous cardiac operations, 24 (17%) had undergone previous AVR...
March 26, 2024: European Journal of Cardio-thoracic Surgery
https://read.qxmd.com/read/38531550/blood-pressure-trends-following-birth-in-infants-born-under-25-weeks-gestational-age-a-retrospective-cohort-study
#2
JOURNAL ARTICLE
Emma Persad, Björn Brindefalk, Alexander Rakow
OBJECTIVE: The aim of our study was to describe postnatal blood pressure (BP) trends and evaluate relevant dynamics and outcomes for a subgroup of extremely preterm (EPT) infants. DESIGN: Retrospective observational cohort study. SETTING: Patients admitted to Karolinska University Hospital Stockholm. PATIENTS: EPT infants born between 22+0 and 24+6 weeks' gestational age (GA) undergoing invasive, continuous BP monitoring through an umbilical arterial catheter...
March 25, 2024: BMJ Paediatrics Open
https://read.qxmd.com/read/38525639/biliary-atresia-the-profile-management-and-outcome-of-patients-treated-at-a-tertiary-hospital-in-central-south-africa
#3
JOURNAL ARTICLE
E Brits, S M Le Grange
BACKGROUND: Biliary atresia (BA) is an obstructive inflammatory disease of the bile ducts. Without intervention, the disease rapidly progresses to liver cirrhosis and fibrosis, with end-stage liver failure and death occurring within the first 3 years of life. It is the most common indication for liver transplantation (LT) in the paediatric population. The management of BA in South Africa (SA) faces multiple challenges, such as late referrals and socioeconomic burdens, with suboptimal outcomes...
November 6, 2023: South African Medical Journal
https://read.qxmd.com/read/38525575/experience-on-postmortem-minimally-invasive-tissue-sampling-to-ascertain-the-cause-of-death-determination-in-south-african-children-a-case-for-implementing-as-standard-of-care
#4
JOURNAL ARTICLE
J Du Toit, K Storath, I Dunn, P Makekeng, M Moosa, K Mothibi, N Umuneza, C A Rees, D Blau, S Lala, Y Adam, S Velaphi, M Hale, P Swart, J Wadula, L Mothibi, A Wise, V Baba, P Jaglal, S Mahtab, S Madhi, Z Dangor
Determining the death burden for prioritising public health interventions necessitates detailed data on the causal pathways to death. Postmortem minimally invasive tissue sampling (MITS), incorporating histology, molecular and microbial culture diagnostics, enhances cause-of-death attribution, particularly for infectious deaths. MITS proves a valid alternative to full diagnostic autopsies, especially in low- and middle-income countries. In Soweto, South Africa (SA), the Child Health and Mortality Prevention Surveillance (CHAMPS) programme has delineated over 1 000 child and stillbirth deaths since 2017...
February 13, 2024: South African Medical Journal
https://read.qxmd.com/read/38522443/effectiveness-of-bubble-continuous-positive-airway-pressure-for-treatment-of-children-aged-1-59-months-with-severe-pneumonia-and-hypoxaemia-in-ethiopia-a-pragmatic-cluster-randomised-controlled-trial
#5
JOURNAL ARTICLE
Meseret Gebre, Kassa Haile, Trevor Duke, Md Tanveer Faruk, Mehnaz Kamal, Md Farhad Kabir, Md Fakhar Uddin, Muluye Shimelis, Tigist Beyene, Bethelhem Solomon, Meles Solomon, Abebe Genetu Bayih, Alemseged Abdissa, Taye Tolera Balcha, Rahel Argaw, Asrat Demtse, Abate Yeshidinber Weldetsadik, Abayneh Girma, Bitseat W Haile, Abu Sadat Mohammad Sayeem Bin Shahid, Tahmeed Ahmed, John D Clemens, Mohammod Jobayer Chisti
BACKGROUND: The safety and efficacy of bubble continuous positive airway pressure (bCPAP) for treatment of childhood severe pneumonia outside tertiary care hospitals is uncertain. We did a cluster-randomised effectiveness trial of locally made bCPAP compared with WHO-recommended low-flow oxygen therapy in children with severe pneumonia and hypoxaemia in general hospitals in Ethiopia. METHODS: This open, cluster-randomised trial was done in 12 general (secondary) hospitals in Ethiopia...
March 21, 2024: Lancet Global Health
https://read.qxmd.com/read/38522210/bored-afraid-alone-what-can-we-learn-from-children-with-paediatric-obesity-about-the-impact-of-the-covid-19-pandemic-for-future-pandemics-care-practices-and-policies
#6
JOURNAL ARTICLE
Siegnella Concincion, Lieke van Houtum, Arnoud Verhoeff, Christine Dedding
PURPOSE: The aim of this study was to gain insight into the perspectives of children with paediatric obesity themselves, during the pandemic and afterwards, regarding their wellbeing and health, and to solicit their advice on tailoring obesity care to match their daily realities. DESIGN AND METHODS: We used a 'draw, write and tell' interview technique, conducted walk-alongs, participant observations and a group session with children with paediatric obesity from seldom-heard communities in Amsterdam, the Netherlands...
March 23, 2024: Journal of Pediatric Nursing
https://read.qxmd.com/read/38521169/transplant-benefit-based-offering-of-deceased-donor-livers-in-the-united-kingdom
#7
JOURNAL ARTICLE
Elisa Allen, Rhiannon Taylor, Alex Ander Gimson, Douglas Thorburn, Dave Collett, Elisa Allen, Varuna Aluvihare, Alex Gimson, Ernest Hidalgo, John O'Grady, Tahir Shah, Doug Thorburn, John Crookenden, Alastair MacGilchrist, James O'Beirne, James Powel, Martine Walmsley
BACKGROUND & AIMS: The National Liver Offering Scheme (NLOS) was introduced in the UK in 2018 to offer livers from deceased donors to patients on the national waiting list based, for most patients, on calculated transplant benefit. Before NLOS, livers were offered to transplant centres by geographic donor zones and, within centres, by estimated recipient need for a transplant. METHODS: UK Transplant Registry data on patient registrations and transplants were analysed to build survival on the list (M1) and survival post-transplantation (M2) statistical models...
March 21, 2024: Journal of Hepatology
https://read.qxmd.com/read/38517865/aetiological-agents-of-pneumonia-among-hiv-and-non-hiv-infected-children-in-ghana-a-case-control-study
#8
JOURNAL ARTICLE
Michael Owusu, Eric Adu, Lotenna Elsie Kalu, Eugene Martey, Godfred Acheampong, Anthony Enimil, John Adabie Appiah, Augustina Badu-Peprah, Justice Sylverken, Augustina Angelina Sylverken, Samuel Blay Nguah, Emilie Westeel, Stephane Pouzol, Christian Drosten, Yaw Adu-Sarkodie
Pneumonia is the leading cause of death in children, however, the microbial aetiology of pneumonia is not well elucidated in low- and middle-income countries. Our study was aimed at determining the microbial aetiologies of childhood pneumonia and associated risk factors in HIV and non-HIV infected children. We conducted a case-control study that enrolled children with pneumonia as cases and non-pneumonia as controls from July 2017 to May 2020. Induced sputum and blood samples were investigated for microbial organisms using standard microbiological techniques...
2024: PloS One
https://read.qxmd.com/read/38511290/between-hope-and-disillusionment-ecmo-seen-through-the-lens-of-nurses-working-in-a-neonatal-and-paediatric-intensive-care-unit
#9
JOURNAL ARTICLE
Jovana A Jucker, Vincenzo Cannizzaro, Roxanne E Kirsch, Jürg C Streuli, Eva De Clercq
BACKGROUND: Using extracorporeal membrane oxygenation (ECMO) in paediatric and neonatal intensive care units (PICU/NICU) creates ethical challenges and carries a high risk for moral distress, burn out and team conflicts. AIM: The study aimed to gain a more comprehensive understanding of the underlying factors affecting moral distress when using ECMO for infants and children by examining the attitudes of ECMO nurses. METHODS: Four focus groups discussions were conducted with 21 critical care nurses working in a Swiss University Children's Hospital...
March 21, 2024: Nursing in Critical Care
https://read.qxmd.com/read/38508661/clinical-cause-of-neonatal-mortality-in-iran-analysis-of-the-national-iranian-maternal-and-neonatal-network
#10
JOURNAL ARTICLE
Abbas Habibelahi, Mohammad Heidarzadeh, Leila Abdollahi, Majzoubeh Taheri, Saber Ghaffari-Fam, Roshanak Vakilian, Amin Daemi
BACKGROUND: The neonatal mortality rate is a main indicator of the health and development of a country. Having insight into the cause of neonatal deaths may be the first step to reducing it. This paper depicts the cause of newborn deaths in Iran. METHODS: This cross-sectional study was performed on data from the national Iranian Maternal And Neonatal network to investigate all neonatal deaths in the country during the year 2019. The cause of death data were reported according to categories of birth weight, gestational age (GA), death time and place...
March 20, 2024: BMJ Paediatrics Open
https://read.qxmd.com/read/38508660/healthcare-service-use-and-medical-outcomes-of-tracheostomy-dependent-children-a-nationwide-study
#11
JOURNAL ARTICLE
In Gyu Song, You Sun Kim, Min Sun Kim, Ji Weon Lee, Yoon-Min Cho, Youna Lim, Seong Keun Kwon, Dong In Suh, June Dong Park
BACKGROUND: Despite the rising trend of tracheostomies in children, there is a lack of comprehensive resources for families to navigate the challenges of living with a tracheostomy, emphasising the need for evidence-based support in understanding postoperative care and long-term adjustments. This study aimed to examine the pattern of using healthcare services and nationwide medical outcomes in children who underwent a tracheotomy before the age of 2 years. METHODS: This retrospective study used the National Health Insurance System database from 2008 to 2016 and included all children codified with tracheotomy procedure codes before their second birthday...
March 19, 2024: BMJ Paediatrics Open
https://read.qxmd.com/read/38499513/availability-and-stock-outs-of-paediatric-antiretroviral-treatment-formulations-at-health-facilities-in-kenya-and-uganda
#12
JOURNAL ARTICLE
Tom G Jacobs, Dorothy Okemo, Anthony Ssebagereka, Kenneth Mwehonge, Emily M Njuguna, David M Burger, Angela Colbers, Fatima Suleman, Aukje K Mantel-Teeuwisse, Gaby I Ooms
INTRODUCTION: The large number of deaths among children with HIV is driven by poor antiretroviral treatment (ART) coverage among this cohort. The aim of the study was to assess the availability and stock-outs of paediatric and adult ART formulations in Kenya and Uganda across various regions and types of health facilities. METHODS: A survey on availability and stock-outs of paediatric ART at health facilities was adapted from the standardized Health Action International-WHO Medicine Availability Monitoring Tool...
March 18, 2024: HIV Medicine
https://read.qxmd.com/read/38499323/assessment-of-adherence-to-the-2020-surviving-sepsis-campaign-guidelines-for-fluid-resuscitation-in-children-with-suspected-septic-shock-in-paediatric-emergency-departments-a-prospective-multicentre-study
#13
JOURNAL ARTICLE
Julian San Geroteo, Michael Levy, Marion Bailhache, Claire De Jorna, Elodie Privat, Oussama Gasmi, Maria Fuentes-Lopez, Yacine Laoudi, Mustapha Mazeghrane, Aline Malterre, Pauline Bories, Khaled Abdel Aal, Iozefina Arjoca, Jean Gaschignard, Davy Tanchaleune, Philippe Minodier, Fabien Audren, Tifanny Mazetier, Pauline Quagliaro, Florence Raimond, Soria Sieng, Blandine Robert, Delphine Wohrer, Nathalie De Suremain, Stéphane Dauger
BACKGROUND: Paediatric sepsis is the leading cause of death in children under 5 years. No studies have evaluated the application of the Surviving Sepsis Campaign 2020 (SSC-2020) guidelines in paediatric emergency departments (PEDs). OBJECTIVE: To assess physician adherence to the SSC-2020 fluid resuscitation guidelines in children with suspected septic shock in PEDs. METHODS: This was a prospective multicentre observational study conducted in 21 French hospitals over 5 sequential weeks, between November 2021 and March 2022...
March 18, 2024: Archives of Disease in Childhood
https://read.qxmd.com/read/38490231/lung-function-trajectories-relevance-and-implementation-in-clinical-practice
#14
REVIEW
Erik Melén, Rosa Faner, James P Allinson, Dinh Bui, Andrew Bush, Adnan Custovic, Judith Garcia-Aymerich, Stefano Guerra, Robab Breyer-Kohansal, Jenny Hallberg, Lies Lahousse, Fernando D Martinez, Simon Kebede Merid, Pippa Powell, Hilary Pinnock, Sanja Stanojevic, Lowie E G W Vanfleteren, Gang Wang, Shyamali C Dharmage, Jadwiga Wedzicha, Alvar Agusti
Lung development starts in utero and continues during childhood through to adolescence, reaching its peak in early adulthood. This growth is followed by gradual decline due to physiological lung ageing. Lung-function development can be altered by several host and environmental factors during the life course. As a result, a range of lung-function trajectories exist in the population. Below average trajectories are associated with respiratory, cardiovascular, metabolic, and mental health comorbidities, as well as with premature death...
March 12, 2024: Lancet
https://read.qxmd.com/read/38482147/coverage-gaps-in-empiric-antibiotic-regimens-used-to-treat-serious-bacterial-infections-in-neonates-and-children-in-southeast-asia-and-the-pacific
#15
JOURNAL ARTICLE
Phoebe C M Williams, Mark Jones, Thomas L Snelling, Robert Duguid, Nerida Moore, Benjamin Dickson, Yue Wu, Jessica Saunders, Priyali Wijeratne, Anousone Douangnouvong, Elizabeth A Ashley, Paul Turner
BACKGROUND: High levels of antimicrobial resistance (AMR) are propagating deaths due to neonatal and paediatric infections globally. This is of particular concern in Southeast Asia and the Pacific, where healthcare resources are constrained and access to newer agents to treat multidrug-resistant pathogens is limited. METHODS: To assess the coverage provided by commonly prescribed empiric antibiotic regimens for children in low- and middle-income countries in Southeast Asia and the Pacific, we built a weighted incidence syndromic combination antibiogram (WISCA), parameterised using data obtained from a systematic review of published literature incorporating WHO-defined SEARO and WPRO regions in Ovid MEDLINE, EMBASE, Global Health and PubMed...
March 2024: Lancet Reg Health Southeast Asia
https://read.qxmd.com/read/38481215/a-dutch-paediatric-palliative-care-guideline-a-systematic-review-and-evidence-based-recommendations-for-symptom-treatment
#16
JOURNAL ARTICLE
Kim C van Teunenbroek, Renée L Mulder, Inge M L Ahout, Karen G C B Bindels-de Heus, Catharina M Delsman-van Gelder, Annemie F S Galimont-Collen, Marinka A R de Groot, Katja M J Heitink-Polle, Jeffry Looijestijn, Maarten O Mensink, Selma Mulder, Jolanda H Schieving, Antoinette Y N Schouten-van Meeteren, Johannes M A Verheijden, Hester Rippen, Brigitt C M Borggreve, Leontien C M Kremer, A A Eduard Verhagen, Erna M C Michiels
BACKGROUND: Children with life-threatening and life-limiting conditions can experience high levels of suffering due to multiple distressing symptoms that result in poor quality of life and increase risk of long-term distress in their family members. High quality symptom treatment is needed for all these children and their families, even more so at the end-of-life. In this paper, we provide evidence-based recommendations for symptom treatment in paediatric palliative patients to optimize care...
March 13, 2024: BMC Palliative Care
https://read.qxmd.com/read/38470396/a-tagging-polymorphism-in-fat-mass-and-obesity-associated-fto-gene-is-associated-with-sepsis-status-in-children
#17
JOURNAL ARTICLE
Petr Jabandziev, Jaroslav Alois Hubacek, Jaroslav Michalek, Martin Jouza, Jan Papez, Jakub Pecl, Katerina Slaba, Ondrej Slaby, Milan Urik, Stefania Aulicka, Lumir Kunovsky, Jaroslav Michalek, Petr Dominik, Milan Kratochvil, Jozef Klucka, Petr Stourac
INTRODUCTION: Sepsis is one of the most common causes of death in patients admitted to intensive care units (ICUs). The development of sepsis is significantly influenced by genetic predisposition. In this study, we highlight a potential association between a variant of the fat mass and obesity-associated ( FTO ) gene and risk of sepsis in children and adolescents. METHODS: We investigated a first-intron tagging FTO polymorphism (rs17817449) by comparing a severe condition (SC) group, comprising 598 paediatric patients (ages 0-19 years) admitted to an ICU with fever, systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, septic shock, or multiple organ dysfunction syndrome (MODS), with a control group consisting of 616 healthy young adults...
March 12, 2024: Romanian Journal of Internal Medicine
https://read.qxmd.com/read/38459348/post-mortem-skeletal-survey-pmss-versus-post-mortem-computed-tomography-pmct-for-the-detection-of-corner-metaphyseal-lesions-cml-in-children
#18
JOURNAL ARTICLE
Susan Cheng Shelmerdine, Natasha Davendralingam, Dean Langan, Liina Palm, Chas Mangham, Owen J Arthurs
OBJECTIVES: Corner metaphyseal lesions (CMLs) are specific for child abuse but challenging to detect on radiographs. The accuracy of CT for CML detection is unknown. Our aim was to compare diagnostic accuracy for CML detection on post-mortem skeletal surveys (PMSS, plain radiography) versus post-mortem CT (PMCT). METHODS: A 10-year retrospective review was performed at a children's hospital for patients having PMSS, PMCT and histopathological correlation (reference standard) for suspected CMLs...
March 9, 2024: European Radiology
https://read.qxmd.com/read/38459131/can-we-screen-for-heart-disease-in-children-at-public-health-centres-a-multicentre-observational-study-of-screening-for-heart-disease-with-a-risk-of-sudden-death-in-children
#19
JOURNAL ARTICLE
Paula Greciano Calero, Silvia Escribá Bori, Juan Antonio Costa Orvay, Nina González Pons, María Del Carmen Martín Pérez, Dolores Cardona Alfonseca, Cristina Nogales Velázquez, Sergi Verd Vallespir, Alicia Esther Tur Salom, Antonella Chiandetti, Marcos Navarro Noguera, Anna Grau Blanch, María Magdalena Rotger Genestar, Marianna Mambié Meléndez, Mercedes Fernández Hidalgo, Juana María Seguí Llinas, Laura Martorell Bon, Patricia Arestuche Aguilar, Beatriz Garrido Conde, María Del Valle Sánchez Grao, Katia Sarraff Trujillo, Antoni Muntaner Alonso, Catalina Grimalt Ferragut, Andrea Soriano Marco, Viviana Gómez Rojas, Juan Pol Serra
Sudden cardiac death in children is a rare event, but of great social significance. Generally, it is related to heart disease with a risk of sudden cardiac death (SCD), which may occur with cardiovascular symptoms and/or electrocardiographic markers; thus, a primary care paediatrician (PCP) could detect them. Therefore, we proposed a study that assesses how to put into practice and conduct a cardiovascular assessment within the routine healthy-child check-ups at six and twelve years of age; that reflects cardiovascular signs and symptoms, as well as the electrocardiographic alterations that children with a risk of SCD in the selected population present; and that assesses the PCP's skill at electrocardiogram (ECG) interpretation...
March 8, 2024: European Journal of Pediatrics
https://read.qxmd.com/read/38454230/crush-syndrome-of-children-in-kahramanmara%C3%A5-earthquake-a-single-center-experience-in-malatya
#20
JOURNAL ARTICLE
Şenay Zırhlı Selçuk, Ahmet Taner Elmas, Yılmaz Tabel
OBJECTIVE: Natural disasters cause enormous environmental, economic, and human losses. Children are the most vulnerable group and face severe consequences. While the primary cause of post-traumatic death is direct injury, the secondary cause is crush syndrome (CS). In this study, we aimed to share our experience in the management of children with CS during disasters by evaluating the clinical and laboratory outcomes of a group of 26 paediatric patients. MATERIALS AND METHODS: Age, weight, length of time under rubble, laboratory results, and characteristics of crush injuries were assessed in 26 paediatric patients admitted to the emergency department after the earthquake...
March 2024: Turkish archives of pediatrics
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