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https://www.readbyqxmd.com/read/29666178/causes-of-death-in-a-contemporary-adult-congenital-heart-disease-cohort
#1
Christopher Yu, Benjamin M Moore, Irina Kotchetkova, Rachael L Cordina, David S Celermajer
OBJECTIVE: The life expectancy of patients with congenital heart disease (CHD) has significantly improved with advances in their paediatric medical care. Mortality patterns are changing as a result. Our study aims to describe survival and causes of death in a contemporary cohort of adult patients with CHD. METHODS: We reviewed 3068 patients in our adult CHD database (age ≥16 years, seen at least once in our centre between 2000 and 2015), and documented the number and causes of death, via Australia's National Death Index...
April 17, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29662693/paediatric-and-obstetric-outcomes-at-a-faith-based-hospital-during-the-100-day-public-sector-physician-strike-in-kenya
#2
Mary Beth Adam, Sarah Muma, Jecinter Achieng Modi, Mardi Steere, Nate Cook, Wayne Ellis, Catherine T Chen, Arianna Shirk, John K Muma Nyagetuba, Erik N Hansen
Published reviews of national physician strikes have shown a reduction in patient mortality. From 5 December 2016 until 14 March 2017, Kenyan physicians in the public sector went on strike leaving only private (not-for-profit and for-profit) hospitals able to offer physician care. We report on our experience at AIC-Kijabe Hospital, a not-for-profit, faith-based Kenyan hospital, before, during and after the 100-day strike was completed by examining patient admissions and deaths in the time periods before, during and after the strike...
2018: BMJ Global Health
https://www.readbyqxmd.com/read/29650429/-emergency-department-consultations-associated-with-unintentional-injuries-a-cases-series
#3
Cristina Arribas Sánchez, Eduardo J Bardón Cancho, Arístides Rivas García, Santiago Mintegi, Rafael Marañón Pardillo
OBJECTIVE: To analyse the clinical and epidemiological characteristics of children who are attended in Emergency Departments (EDs) for an unintentional injury in Spain. METHODS: Multicentre case series with prospective data collection conducted during 12 months in the ED of 11 hospitals belonging to the Spanish Paediatric Emergency Research Group. Data were collected between September 2014 and January 2015, continuing for one year in all paediatric EDs, and included children between 0 and 16 years old seen for an unintentional injury...
April 9, 2018: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29629679/feasibility-and-acceptability-of-conducting-hiv-vaccine-trials-in-adolescents-in-south-africa-going-beyond-willingness-to-participate-towards-implementation
#4
M Wallace, K Middelkoop, P Smith, C Pike, T Bennie, J Chandia, G Churchyard, G Gray, M H Latka, M Mathebula, M Nchabeleng, S Roux, C Slack, A Strode, L-G Bekker
BACKGROUND: HIV/AIDS remains a leading cause of death in adolescents (aged 15 - 25 years), and in sub-Saharan Africa HIV-related deaths continue to rise in this age group despite a decline in both adult and paediatric populations. This is attributable in part to high adolescent infection rates and supports the urgent need for more efficacious prevention strategies. In particular, an even partially effective HIV vaccine, given prior to sexual debut, is predicted to significantly curb adolescent infection rates...
March 28, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/29621302/factors-associated-with-death-and-loss-to-follow-up-in-children-on-antiretroviral-care-in-mingalardon-specialist-hospital-myanmar-2006-2016
#5
Kay Khaing Kaung Nyunt, Wai Wai Han, Srinath Satyanarayana, Petros Isaakidis, San Hone, Aye Aye Khaing, Hoa Nguyen Binh, Htun Nyunt Oo
BACKGROUND: Myanmar National AIDS programme's priority is to improve the survival of all people living with HIV by providing anti-retroviral therapy (ART) care. More than 7200 children (aged <15 years) have been enrolled into ART care from 2005 to 2016. A previous study showed that ~11% children on ART care had either died or were lost to follow-up by 60 months. Factors associated with death and lost-to follow-up (adverse outcomes) have not been previously studied. OBJECTIVES: To describe the association between demographic and clinical characteristics at enrollment into ART care with adverse outcomes...
2018: PloS One
https://www.readbyqxmd.com/read/29618484/evaluating-the-process-and-outcomes-of-child-death-review-in-the-solomon-islands
#6
Mathew Sandakabatu, Titus Nasi, Carol Titiulu, Trevor Duke
While maternal and perinatal mortality auditing has been strongly promoted by the World Health Organization (WHO), there has been very limited promotion or evaluation of child death auditing in low/middle-income settings. In 2017, a standardised child death review process was introduced in the paediatric department of the National Hospital in Honiara, Solomon Islands. We evaluated the process and outcomes of child death reviews. The child death auditing process was assessed through systematic observations made at each of the weekly meetings using the following standards for evaluation: (1) adapted WHO tools for paediatric auditing; (2) the five stages of the audit cycle; (3) published principles of paediatric audit; and (4) WHO and Solomon Islands national clinical standards of Hospital Care for Children...
April 4, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29617989/knowledge-of-venomous-snakes-snakebite-first-aid-treatment-and-prevention-among-clinicians-in-northern-nigeria-a-cross-sectional-multicentre-study
#7
Godpower C Michael, Bukar A Grema, Ibrahim Aliyu, Mohammed A Alhaji, Teslim O Lawal, Haliru Ibrahim, Aminu G Fikin, Fatima S Gyaran, Kennedy N Kane, Thomas D Thacher, Abba K Badamasi, Emmanuel Ogwuche
Background: Snakebite envenoming causes considerable morbidity and mortality in northern Nigeria. The clinician's knowledge of snakebite impacts outcome. We assessed clinicians' knowledge of snakebite envenoming to highlight knowledge and practice gaps for possible intervention to improve snakebite outcomes. Methods: This was a cross-sectional multicentre study of 374 doctors selected from the accident and emergency, internal medicine, family medicine/general outpatient, paediatrics and surgery departments of nine tertiary hospitals in northern Nigeria using a multistage sampling technique...
March 29, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29605169/burnout-and-posttraumatic-stress-in-paediatric-critical-care-personnel-prediction-from-resilience-and-coping-styles
#8
Rocío Rodríguez-Rey, Alba Palacios, Jesús Alonso-Tapia, Elena Pérez, Elena Álvarez, Ana Coca, Santiago Mencía, Ana Marcos, Juan Mayordomo-Colunga, Francisco Fernández, Fernando Gómez, Jaime Cruz, Olga Ordóñez, Ana Llorente
INTRODUCTION: Our aims were (1) to explore the prevalence of burnout syndrome (BOS) and posttraumatic stress disorder (PTSD) in a sample of Spanish staff working in the paediatric intensive care unit (PICU) and compare these rates with a sample of general paediatric staff and (2) to explore how resilience, coping strategies, and professional and demographic variables influence BOS and PTSD. MATERIALS AND METHODS: This is a multicentre, cross-sectional study. Data were collected in the PICU and in other paediatric wards of nine hospitals...
March 28, 2018: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
https://www.readbyqxmd.com/read/29587223/hallmarks-of-alzheimer-disease-are-evolving-relentlessly-in-metropolitan-mexico-city-infants-children-and-young-adults-apoe4-carriers-have-higher-suicide-risk-and-higher-odds-of-reaching-nft-stage-v-at-%C3%A2-40-years-of-age
#9
Lilian Calderón-Garcidueñas, Angélica Gónzalez-Maciel, Rafael Reynoso-Robles, Ricardo Delgado-Chávez, Partha S Mukherjee, Randy J Kulesza, Ricardo Torres-Jardón, José Ávila-Ramírez, Rodolfo Villarreal-Ríos
Exposures to fine particulate matter (PM2.5 ) and ozone (O3 ) above USEPA standards are associated with Alzheimer's disease (AD) risk. Metropolitan Mexico City (MMC) residents have life time exposures to PM2.5 and O3 above USEPA standards. We investigated AD intra and extracellular protein aggregates and ultrastructural neurovascular pathology in 203 MMC residents age 25.36 ± 9.23 y. Immunohistochemical methods were used to identify AT8 hyperphosphorilated tau (Htau) and 4G8 (amyloid β 17-24). Primary outcomes: staging of Htau and amyloid, per decade and cumulative PM2...
March 24, 2018: Environmental Research
https://www.readbyqxmd.com/read/29579354/penetrating-head-injuries-in-children-presenting-to-the-emergency-department-in-australia-and-new-zealand-a-predict-prospective-study
#10
Franz E Babl, Mark D Lyttle, Silvia Bressan, Meredith L Borland, Natalie Phillips, Amit Kochar, Sarah Dalton, John A Cheek, Yuri Gilhotra, Jeremy Furyk, Jocelyn Neutze, Susan Donath, Stephen Hearps, Marta Arpone, Louise Crowe, Stuart R Dalziel, Ruth Barker, Ed Oakley
AIM: Penetrating head injuries (pHIs) are associated with high morbidity and mortality. Data on pHIs in children outside North America are limited. We describe the mechanism of injuries, neuroimaging findings, neurosurgery and mortality for pHIs in Australia and New Zealand. METHODS: This was a planned secondary analysis of a prospective observational study of children <18 years who presented with a head injury of any severity at any of 10 predominantly paediatric Australian/New Zealand emergency departments (EDs) between 2011 and 2014...
March 26, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29579186/arrhythmias-in-congenital-heart-disease-a-position-paper-of-the-european-heart-rhythm-association-ehra-association-for-european-paediatric-and-congenital-cardiology-aepc-and-the-european-society-of-cardiology-esc-working-group-on-grown-up-congenital-heart-disease
#11
Antonio Hernández-Madrid, Thomas Paul, Dominic Abrams, Peter F Aziz, Nico A Blom, Jian Chen, Massimo Chessa, Nicolas Combes, Nikolaos Dagres, Gerhard Diller, Sabine Ernst, Alessandro Giamberti, Joachim Hebe, Jan Janousek, Thomas Kriebel, Jose Moltedo, Javier Moreno, Rafael Peinado, Laurent Pison, Eric Rosenthal, Jonathan R Skinner, Katja Zeppenfeld
The population of patients with congenital heart disease (CHD) is continuously increasing with more and more patients reaching adulthood. A significant portion of these young adults will suffer from arrhythmias due to the underlying congenital heart defect itself or as a sequela of interventional or surgical treatment. The medical community will encounter an increasing challenge as even most of the individuals with complex congenital heart defects nowadays become young adults. Within the past 20 years, management of patients with arrhythmias has gained remarkable progress including pharmacological treatment, catheter ablation, and device therapy...
March 20, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29578406/neurovascular-sequestration-in-paediatric-p-falciparum-malaria-is-visible-clinically-in-the-retina
#12
Valentina Barrera, Ian Jc MacCormick, Gabriela Czanner, Paul Stephenson Hiscott, Valerie Ann White, Alister G Craig, Nicholas Alexander Venton Beare, Lucy Hazel Culshaw, Yalin Zheng, Simon Charles Biddolph, Danny A Milner, Steve Kamiza, Malcolm E Molyneux, Terrie E Taylor, Simon Peter Harding
Retinal vessel changes and retinal whitening, distinctive features of malarial retinopathy, can be directly observed during routine eye examination in children with P.falciparum cerebral malaria. We investigated their clinical significance and underlying mechanisms through linked clinical, clinicopathological and image analysis studies. Orange vessels and severe foveal whitening (clinical examination, n=817, OR, 95% CI: 2.90, 1.96-4.30; 3.4, 1.8-6.3, both p<0.001), and arteriolar involvement by intravascular filling defects (angiographic image analysis, n=260, 2...
March 26, 2018: ELife
https://www.readbyqxmd.com/read/29571596/bereaved-parents-experiences-of-the-police-in-the-paediatric-intensive-care-unit
#13
Ashleigh E Butler, Helen Hall, Beverley Copnell
BACKGROUND: A child's death in the intensive care unit is often sudden and unexpected, requiring the involvement of the state coroner to investigate both the cause and the circumstances surrounding the death. This process often involves the police, who arrive in intensive care to identify the body and collect statements from the parents. At present, very little is known about parents' experiences of this process. OBJECTIVES: To explore bereaved parents' experiences of police presence in intensive care, as part of routine coronial investigations...
March 20, 2018: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
https://www.readbyqxmd.com/read/29567665/paediatric-ebstein-s-anomaly-how-clinical-presentation-predicts-mortality
#14
Lianne M Geerdink, Tammo Delhaas, Willem A Helbing, Gideon J du Marchie Sarvaas, Henriette Ter Heide, Lieke Rozendaal, Chris L de Korte, Petronella G M Peer, Irene M Kuipers, Livia Kapusta
BACKGROUND: Forecasting the prognosis of a child when diagnosed with Ebstein's anomaly is difficult. We, therefore, studied which factors at the time of diagnosis are associated with death during childhood. METHODS: All consecutive patients (0-18 years) diagnosed with Ebstein's anomaly in the Netherlands between 1980 and 2014 were included. Survival curves were obtained using the Kaplan-Meier method. By using the Cox proportional hazard model, we analysed the factors (at diagnosis) that were associated with death...
March 22, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29566695/cerebrospinal-fluid-plasmodium-falciparum-histidine-rich-protein-2-in-pediatric-cerebral-malaria
#15
Kiran T Thakur, Jimmy Vareta, Kathryn A Carson, Samuel Kampondeni, Michael J Potchen, Gretchen L Birbeck, Ian MacCormick, Terrie Taylor, David J Sullivan, Karl B Seydel
BACKGROUND: Cerebral malaria (CM) causes a rapidly developing coma, and remains a major contributor to morbidity and mortality in malaria-endemic regions. This study sought to determine the relationship between cerebrospinal fluid (CSF) Plasmodium falciparum histidine rich protein-2 (PfHRP-2) and clinical, laboratory and radiographic features in a cohort of children with retinopathy-positive CM. METHODS: Patients included in the study were admitted (2009-2013) to the Pediatric Research Ward (Queen Elizabeth Central Hospital, Blantyre, Malawi) meeting World Health Organization criteria for CM with findings of malarial retinopathy...
March 23, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29566441/all-cause-mortality-rates-and-home-deaths-decreased-in-children-with-life-limiting-diagnoses-in-denmark-between-1994-and-2014
#16
Camilla Lykke, Ola Ekholm, Kjeld Schmiegelow, Marianne Olsen, Per Sjøgren
AIM: Specialised paediatric palliative care has not previously been a priority in Denmark. The aim of this study was to support its development and organisation, by examining why and where children died using official national data for 1994-2014. METHODS: We obtained data on 9,462 children who died before the age of 18 from the Danish Register of Causes of Death. The causes of deaths were listed according to the codes in the International Classification of Diseases...
March 22, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29557351/acute-mechanical-intestinal-obstruction-in-children-at-zinder-national-hospital-niger-aetiologies-and-prognosis
#17
Harissou Adamou, Ibrahim Amadou Magagi, Oumarou Habou, Ousseini Adakal, Kabirou Ganiou, Magagi Amadou
Background: To describe the aetiological and prognostic aspects of acute mechanical intestinal obstruction (AMIO) in children at Zinder National Hospital (Niger). Materials and Methods: This was a cross-sectional study on a period to January 2013-June 2015. The database included all children under 15 years of age with a surgical diagnosis of mechanical intestinal obstruction. P < 0.05 was considered statistically significant for analysis. Results: AMIOs represent 21...
July 2017: African Journal of Paediatric Surgery: AJPS
https://www.readbyqxmd.com/read/29545594/high-transplant-related-mortality-associated-with-haematopoietic-stem-cell-transplantation-for-paediatric-therapy-related-acute-myeloid-leukaemia-t-aml-a-study-on-behalf-of-the-united-kingdom-paediatric-blood-and-bone-marrow-transplant-group
#18
Adam Gassas, Ponni Sivaprakasam, Michelle Cummins, Patricia Breslin, Katharine Patrick, Mary Slatter, Roderick Skinner, Geof Shenton, Brenda Gibson, Sarah Lawson, Toni Petterson, Michael Potter, Beki James, Rachael Hough, Prashant Hiwarkar, Ajay Vora, Paul Veys, Josu De La Fuente, Robert Wynn, Persis Amrolia
Paediatric therapy-related acute myeloid leukaemia (t-AML) is rare and the outcome is poor. While allogeneic haematopoietic stem cell transplantation (HSCT) is generally the accepted modality of treatment, data regarding salvage chemotherapy, remission induction, conditioning regimens, transplant-related mortality and outcome is scarce. Between 2000 and2016, 36 children with t-AML were treated in seven UK paediatric HSCT centres. The most common salvage protocol for remission induction was FLAG with or without idarubicin and 28 patients were in complete morphological remission prior to BMT...
March 15, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29541477/first-description-of-a-local-coprinopsis-cinerea-skin-and-soft-tissue-infection
#19
C Correa-Martinez, A Brentrup, K Hess, K Becker, A H Groll, F Schaumburg
Coprinopsis cinerea is an environmental fungus which can cause disseminated infections in immunocompromised patients, often leading to death. Here we report the case of a paediatric patient with an invasive wound infection due to C. cinerea, which was successfully treated with surgical debridement and oral posaconazole.
January 2018: New Microbes and New Infections
https://www.readbyqxmd.com/read/29534694/predicting-the-severity-of-dengue-fever-in-children-on-admission-based-on-clinical-features-and-laboratory-indicators-application-of-classification-tree-analysis
#20
Khansoudaphone Phakhounthong, Pimwadee Chaovalit, Podjanee Jittamala, Stuart D Blacksell, Michael J Carter, Paul Turner, Kheng Chheng, Soeung Sona, Varun Kumar, Nicholas P J Day, Lisa J White, Wirichada Pan-Ngum
BACKGROUND: Dengue fever is a re-emerging viral disease commonly occurring in tropical and subtropical areas. The clinical features and abnormal laboratory test results of dengue infection are similar to those of other febrile illnesses; hence, its accurate and timely diagnosis for providing appropriate treatment is difficult. Delayed diagnosis may be associated with inappropriate treatment and higher risk of death. Early and correct diagnosis can help improve case management and optimise the use of resources such as hospital staff, beds, and intensive care equipment...
March 13, 2018: BMC Pediatrics
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