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https://www.readbyqxmd.com/read/28231672/-analysis-on-cancer-deaths-and-cause-eliminated-life-expectancy-among-residents-of-tianjin-2015
#1
Z L Xu, H Zhang, D Z Wang, G D Song, C F Shen, S Zhang, Y Zhang, G H Jiang
Objective: To explore the causes of cancer deaths and cause-eliminated-life-expectancy among residents of Tianjin. Methods: Data from the death registry system of Tianjin residents in 2015 were collected and cancers were grouped according to the classification of Global Burden of Disease. Specific cancer crude death rate and cause eliminated life expectancy (CELE) were calculated. Results: In 2015, 17 641 Tianjin residents died of cancer, with the crude death rate as 171.79 per 100 thousand and the standardized rate according to the Chinese population in 2000 as 86...
February 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28231667/-association-between-body-mass-index-and-both-total-and-cause-specific-mortality-in-china-findings-from-data-through-the-china-kadoorie-biobank
#2
L X Wang, M Y Fan, C Q Yu, Y Guo, Z Bian, Y L Tan, P Pei, J S Chen, J Lyu, L M Li
Objective: To evaluate the associations between body mass index (BMI) and both total and cause-specific mortality. Methods: After excluding participants with heart disease, stroke, cancer, chronic obstructive pulmonary disease, and diabetes at baseline study, 428 593 participants aged 30-79 in the China Kadoorie Biobank study were chosen for this study. Participants were categorized into 9 groups according to their BMI status. Cox regression analysis was used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) of mortality on BMI...
February 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28231497/dienogest-and-deep-infiltrating-endometriosis-the-remission-of-symptoms-is-not-related-to-endometriosis-nodule-remission
#3
Joao Paulo Leonardo-Pinto, Cristina Laguna Benetti-Pinto, Kleber Cursino, Daniela Angerame Yela
OBJECTIVE: To evaluate the effectiveness of dienogest in controlling pain caused by deep infiltrating endometriosis (DIE), its influence on the quality of live (QoL) of women affected by the disease, and the effect of the drug on the volume of endometriotic lesions. STUDY DESIGN: A prospective cohort study including 30 women with a sonographic diagnosis of DIE (intestinal and posterior fornix) treated with dienogest 2mg per day for 12 months. We evaluated the pain symptoms and the volume of the intestinal and posterior fornix lesions before and after 12 months of use of dienogest...
February 15, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28231421/varying-demographic-impacts-of-different-fisheries-on-three-mediterranean-seabird-species
#4
M Genovart, D Doak, J M Igual, S Sponza, J Kralj, D Oro
Fisheries have an enormous economic importance but reconciling their socio-economic features with the conservation and sustainability of marine ecosystems presents major challenges. Bycatch mortality from fisheries is clearly among the most serious global threats for marine ecosystems, affecting a wide range of top predators. Recent estimates report ca. 200,000 seabirds killed annually by bycatch in European waters. However there is an urgent need to rigorously estimate actual mortality rates and quantify effects of bycatch on populations...
February 23, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28231241/hydrocephalus-and-arthrogryposis-in-an-immunocompetent-mouse-model-of-zika-teratogeny-a-developmental-study
#5
Jose Xavier-Neto, Murilo Carvalho, Bruno Dos Santos Pascoalino, Alisson Campos Cardoso, Ângela Maria Sousa Costa, Ana Helena Macedo Pereira, Luana Nunes Santos, Ângela Saito, Rafael Elias Marques, Juliana Helena Costa Smetana, Silvio Roberto Consonni, Carla Bandeira, Vivian Vasconcelos Costa, Marcio Chaim Bajgelman, Paulo Sérgio Lopes de Oliveira, Marli Tenorio Cordeiro, Laura Helena Vega Gonzales Gil, Bianca Alves Pauletti, Daniela Campos Granato, Adriana Franco Paes Leme, Lucio Freitas-Junior, Carolina Borsoi Moraes Holanda de Freitas, Mauro Martins Teixeira, Estela Bevilacqua, Kleber Franchini
The teratogenic mechanisms triggered by ZIKV are still obscure due to the lack of a suitable animal model. Here we present a mouse model of developmental disruption induced by ZIKV hematogenic infection. The model utilizes immunocompetent animals from wild-type FVB/NJ and C57BL/6J strains, providing a better analogy to the human condition than approaches involving immunodeficient, genetically modified animals, or direct ZIKV injection into the brain. When injected via the jugular vein into the blood of pregnant females harboring conceptuses from early gastrulation to organogenesis stages, akin to the human second and fifth week of pregnancy, ZIKV infects maternal tissues, placentas and embryos/fetuses...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28230898/manifestations-and-medicolegal-significance-of-loeys-dietz-syndrome
#6
Roger W Byard
Loeys-Dietz syndrome is a recently described autosomal dominant disorder with underlying vasculopathy characterized by aortic and other vascular aneurysmal dissection/rupture. A 61-year-old man is reported who died suddenly and unexpectedly and at autopsy was found to have a ruptured abdominal aortic aneurysm. Additional findings included dolichostenomelia, high-arched palate, and pectus excavatum. There was a strong family history of Loeys-Dietz syndrome, although the decedent had never been tested. Death was, therefore, due to a ruptured abdominal aortic aneurysm in a case of probable Loeys-Dietz syndrome...
February 23, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28230897/unnatural-and-violent-death-in-cases-with-high-blood-alcohol-concentration-autopsy-study
#7
Danica Cvetković, Vladimir Živković, Vera Lukić, Slobodan Nikolić
The use of alcohol increases the risk of dying from unnatural or violent causes. The presented study explored the distribution of age, gender, cause, and circumstances of death in persons who died in an unnatural and violent manner, with a blood alcohol concentration (BAC) higher than 0.3 g/dL, and where the cause of death was not alcohol intoxication. We defined the control (0 < BAC < 0.3 g/dL) and study (BAC ≥ 0.3 g/dL) groups, as in subjects with these concentrations, there is a significant risk of gross intoxication, stupor, and death...
February 23, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28230318/liver-related-mortality-and-hospitalizations-attributable-to-chronic-hepatitis-c-virus-coinfection-in-persons-living-with-hiv
#8
A Mena, H Meijide, I Rodríguez-Osorio, A Castro, E Poveda
OBJECTIVES: The aim of this study was to compare liver-related mortality and liver-related hospitalizations for persons living with HIV (PLWH) with and without hepatitis C virus (HCV) exposure, and to estimate the fraction of liver disease attributable to chronic HCV coinfection. METHODS: An ambispective cohort study followed PLWH between 1993 and 2014. PLWH were classified into three groups: those who were HIV-monoinfected, those who cleared HCV spontaneously and those with chronic HCV coinfection...
February 23, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28230236/a-proposal-of-post-operative-nomogram-for-overall-survival-in-patients-with-renal-cell-carcinoma-and-venous-tumor-thrombus
#9
Liangyou Gu, Zihuan Wang, Luyao Chen, Xin Ma, Hongzhao Li, Wenyuan Nie, Cheng Peng, Xintao Li, Yu Gao, Xu Zhang
OBJECTIVE: To identify the predictors of overall survival (OS) and create a post-operative prognostic model for patients with renal cell carcinoma (RCC) and venous tumor thrombus (VTT). PATIENTS AND METHODS: The study cohort included patients with RCC and VTT that underwent full surgical resection between 2006 and 2016. Univariate and multivariate analyses were used to determine the prognostic factors of OS. A nomogram was developed and internally calibrated by bootstrap resampling method...
February 23, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28230013/iodine-125-radioactive-seed-tissue-implantation-as-a-remedy-treatment-for-recurrent-cervical-cancer
#10
Lei Han, Changlun Li, Junye Wang, Xueqi He, Xiao Zhang, Jundong Yang, Guofeng Liu
PURPOSE: This study was designed to discuss feasibility, short-term efficacy, and complications of iodine-125 radioactive seed tissue implantation for remedying recurrent cervical cancer. MATERIALS AND METHODS: From June 2009 to December 2010, 17 patients with recurrent cervical cancer received radioactive seed implantation under computed tomography (CT) guidance. Matched peripheral dose was 145 Gy, while the number of implanted seeds was from 6 to 68 with a median of 20...
December 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28229924/outcomes-in-adults-and-children-with-end-stage-kidney-disease-requiring-dialysis-in-sub-saharan-africa-a-systematic-review
#11
Gloria Ashuntantang, Charlotte Osafo, Wasiu A Olowu, Fatiu Arogundade, Abdou Niang, John Porter, Saraladevi Naicker, Valerie A Luyckx
BACKGROUND: The burden of end-stage kidney disease (ESKD) in sub-Saharan Africa is unknown but is probably high. Access to dialysis for ESKD is limited by insufficient infrastructure and catastrophic out-of-pocket costs. Most patients remain undiagnosed, untreated, and die. We did a systematic literature review to assess outcomes of patients who reach dialysis and the quality of dialysis received. METHODS: We searched PubMed, African Journals Online, WHO Global Health Library, and Web of Science for articles in English or French from sub-Saharan Africa reporting dialysis outcomes in patients with ESKD published between Jan 1, 1990, and Dec 22, 2015...
February 17, 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28229893/safety-and-efficacy-of-natalizumab-in-patients-with-acute-ischaemic-stroke-action-a-randomised-placebo-controlled-double-blind-phase-2-trial
#12
Jacob Elkins, Roland Veltkamp, Joan Montaner, S Claiborne Johnston, Aneesh B Singhal, Kyra Becker, Maarten G Lansberg, Weihua Tang, Ih Chang, Kumar Muralidharan, Sarah Gheuens, Lahar Mehta, Mitchell S V Elkind
BACKGROUND: In animal models of acute ischaemic stroke, blocking of the leukocyte-endothelium adhesion by antagonism of α4 integrin reduces infarct volumes and improves outcomes. We assessed the effect of one dose of natalizumab, an antibody against the leukocyte adhesion molecule α4 integrin, in patients with acute ischaemic stroke. METHODS: In this double-blind, phase 2 study, patients with acute ischaemic stroke (aged 18-85 years) from 30 US and European clinical sites were randomly assigned (1:1) to 300 mg intravenous natalizumab or placebo with stratification by treatment window and baseline infarct size...
March 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28229608/usefulness-of-an-intra-gastric-balloon-before-bariatric-surgery
#13
Cristina Vicente, Luis Ramón Rábago, Alejandro Ortega, Marisa Arias, Jaime Vázquez Echarri
INTRODUCTION: There are only few reports regarding the use of intragastric-balloons (IGB®) to achieve weight loss and subsequently decrease surgical complications. In this study, we try to assess whether presurgery weight loss using IGB decreases the postsurgical mortality after bariatric surgery. METHODS: This is a prospective case-control study. We matched 1:1 by gender, age (± 10 y-o) and type of surgery (sleeve resection [LSG] or gastric bypass [LGBP]), matching cases (A) and controls (H, from a historic cohort)...
23, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28229358/postmastectomy-radiation-therapy-and-breast-reconstruction-with-autologous-tissue
#14
Yasunobu Terao, Koichiro Taniguchi, Miwako Fujii, So Moriyama
Immediate breast reconstruction is an important tool for patients to accept and overcome their breast cancer, as well as for cosmetic reasons. However, its use in patients who require postmastectomy radiation therapy (PMRT) is not yet clear. The purpose of this study was to analyze the effects of PMRT and reconstruction on each other. The time of initiation of PMRT, the prognosis, and the cosmetic results were investigated in patients who underwent immediate reconstruction using autologous tissue. In the case of delayed reconstruction using autologous tissue after PMRT, radiation damage of the chest skin, design of the flap, and cosmetic results were investigated...
February 22, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/28229125/the-clinical-neuroanatomical-and-neuropathologic-phenotype-of-tbk1-associated-frontotemporal-dementia-a-longitudinal-case-report
#15
Carolin A M Koriath, Martina Bocchetta, Emilie Brotherhood, Ione O C Woollacott, Penny Norsworthy, Javier Simón-Sánchez, Cornelis Blauwendraat, Katrina M Dick, Elizabeth Gordon, Sophie R Harding, Nick C Fox, Sebastian Crutch, Jason D Warren, Tamas Revesz, Tammaryn Lashley, Simon Mead, Jonathan D Rohrer
INTRODUCTION: Mutations in the TANK-binding kinase 1 (TBK1) gene have recently been shown to cause frontotemporal dementia (FTD). However, the phenotype of TBK1-associated FTD is currently unclear. METHODS: We performed a single case longitudinal study of a patient who was subsequently found to have a novel A705fs mutation in the TBK1 gene. He was assessed annually over a 7-year period with a series of clinical, cognitive, and magnetic resonance imaging assessments...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28228916/species-diversity-and-abundance-of-marine-crabs-portunidae-decapoda-from-a-collapsible-crab-trap-fishery-at-kung-krabaen-bay-chanthaburi-province-thailand
#16
Chutapa Kunsook, Pongchai Dumrongrojwatthana
The diversity and abundance of marine crabs from a collapsible crab trap fishery at Kung Krabaen Bay, Gulf of Thailand, were observed from August 2012 to June 2013 using 10 sampling stations. The results showed that there were seven families, 11 genera and 17 species (two anomuran and 15 brachyuran crabs). The two anomuran species were Clibanarius virescens (1,710 individuals) and Clibanarius infraspinatus (558 individuals). For brachyuran crabs, Portunidae was the most common family, including 10 species. The dominant species of brachyuran crabs included Thalamita crenata (897 individuals), Portunus pelagicus (806 individuals), Charybdis affinis (344 individuals), Scylla sp...
January 2017: Tropical Life Sciences Research
https://www.readbyqxmd.com/read/28228906/histological-assessment-of-the-efficacy-of-drug-eluting-beads-in-portal-tumor-thrombosis-of-hepatocellular-carcinoma
#17
Yusuke Imai, Masashi Hirooka, Yohei Koizumi, Yoshiko Nakamura, Takao Watanabe, Osamu Yoshida, Yoshio Tokumoto, Eiji Takeshita, Masanori Abe, Hiroaki Tanaka, Mie Kurata, Sohei Kitazawa, Yoichi Hiasa
A 58-year-old man was diagnosed with advanced hepatocellular carcinoma with portal vein tumor thrombosis (PVTT). The tumors were multiple and existed in both lobes. Drug-eluting beads transcatheter arterial chemoembolization (DEB-TACE) was performed for the tumors in the left lobe. Embosphere and Hepasphere were selected for embolization of the arterioportal shunt, followed by loaded epirubicin infusion into the left hepatic artery. Computed tomography showed reduction of PVTT. However, liver failure progressed, and the patient died 67 days after DEB-TACE...
March 2017: Radiology case reports
https://www.readbyqxmd.com/read/28228505/postdiagnostic-mediterranean-and-healthy-nordic-dietary-patterns-are-inversely-associated-with-all-cause-mortality-in-long-term-colorectal-cancer-survivors
#18
Ilka Ratjen, Clemens Schafmayer, Romina di Giuseppe, Sabina Waniek, Sandra Plachta-Danielzik, Manja Koch, Ute Nöthlings, Jochen Hampe, Sabrina Schlesinger, Wolfgang Lieb
Background: Dietary factors are known to affect the risk of new-onset colorectal cancer (CRC), but information on the extent to which postdiagnostic diet affects mortality in long-term CRC survivors is scarce.Objective: We investigated the association of 2 a priori-defined postdiagnostic dietary patterns [Modified Mediterranean Diet Score (MMDS) and healthy Nordic Food Index (HNFI)] with all-cause mortality in long-term CRC survivors.Methods: Diet was assessed at a median time of 6 y after cancer diagnosis in 1404 CRC survivors (median age: 69 y; 56% men) in a prospective cohort study in Northern Germany by using a semiquantitative food-frequency questionnaire...
February 22, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28228465/prognostic-value-of-residual-urine-volume-gfr-by-24-hour-urine-collection-and-egfr-in-patients-receiving-dialysis
#19
Mi Jung Lee, Jung Tak Park, Kyoung Sook Park, Young Eun Kwon, Hyung Jung Oh, Tae-Hyun Yoo, Yong-Lim Kim, Yon Su Kim, Chul Woo Yang, Nam-Ho Kim, Shin-Wook Kang, Seung Hyeok Han
BACKGROUND AND OBJECTIVES: Residual kidney function can be assessed by simply measuring urine volume, calculating GFR using 24-hour urine collection, or estimating GFR using the proposed equation (eGFR). We aimed to investigate the relative prognostic value of these residual kidney function parameters in patients on dialysis. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Using the database from a nationwide prospective cohort study, we compared differential implications of the residual kidney function indices in 1946 patients on dialysis at 36 dialysis centers in Korea between August 1, 2008 and December 31, 2014...
February 22, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28228429/two-faces-of-gamma-delta-mycosis-fungoides-before-and-after-renal-transplantation
#20
Knut Erich Prillinger, Franz Trautinger, Melitta Kitzwögerer, Johanna Eder
We describe a patient with a 30-year history of mycosis fungoides (MF) and renal transplantation performed 3 years before he presented with an ulcerated tumour in the lumbosacral area. Biopsy revealed a lymphatic infiltrate of medium-sized, pleomorphic T cells expressing the gamma-delta T-cell receptor. Radiological staging and bone marrow biopsy revealed no extracutaneous involvement. Despite reduction in systemic immunosuppressants, total skin electron beam radiotherapy and systemic chemotherapy, the disease followed a highly aggressive course and the patient died 31 years after initial diagnosis of MF...
February 22, 2017: BMJ Case Reports
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