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https://www.readbyqxmd.com/read/27926935/serological-and-virological-evidence-of-crimean-congo-haemorrhagic-fever-virus-circulation-in-the-human-population-of-borno-state-northeastern-nigeria
#1
David N Bukbuk, Stuart D Dowall, Kuiama Lewandowski, Andrew Bosworth, Saka S Baba, Anitha Varghese, Robert J Watson, Andrew Bell, Barry Atkinson, Roger Hewson
BACKGROUND: Despite several studies on the seroprevalence of antibodies against Crimean-Congo Haemorrhagic Fever virus (CCHFV) from humans and cattle in Nigeria, detailed investigation looking at IgG and IgM have not been reported. Additionally, there have been no confirmed cases of human CCHFV infection reported from Nigeria. PRINCIPAL FINDINGS: Samples from sera (n = 1189) collected from four Local Government Areas in Borno State (Askira/Uba, Damboa, Jere and Maiduguri) were assessed for the presence of IgG and IgM antibodies...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27926930/cytomegalovirus-specific-il-10-producing-cd4-t-cells-are-governed-by-type-i-ifn-induced-il-27-and-promote-virus-persistence
#2
Mathew Clement, Morgan Marsden, Maria A Stacey, Juneid Abdul-Karim, Silvia Gimeno Brias, Diana Costa Bento, Martin J Scurr, Peter Ghazal, Casey T Weaver, Gianluca Carlesso, Simon Clare, Simon A Jones, Andrew Godkin, Gareth W Jones, Ian R Humphreys
CD4+ T cells support host defence against herpesviruses and other viral pathogens. We identified that CD4+ T cells from systemic and mucosal tissues of hosts infected with the β-herpesviridae human cytomegalovirus (HCMV) or murine cytomegalovirus (MCMV) express the regulatory cytokine interleukin (IL)-10. IL-10+CD4+ T cells co-expressed TH1-associated transcription factors and chemokine receptors. Mice lacking T cell-derived IL-10 elicited enhanced antiviral T cell responses and restricted MCMV persistence in salivary glands and secretion in saliva...
December 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27926880/luminal-iron-levels-govern-intestinal-tumorigenesis-after-apc-loss-in%C3%A2-vivo
#3
Sorina Radulescu, Matthew J Brookes, Pedro Salgueiro, Rachel A Ridgway, Ewan McGhee, Kurt Anderson, Samuel J Ford, Daniel H Stones, Tariq H Iqbal, Chris Tselepis, Owen J Sansom
No abstract text is available yet for this article.
December 6, 2016: Cell Reports
https://www.readbyqxmd.com/read/27926868/cmyc-regulates-the-size-of-the-premigratory-neural-crest-stem-cell-pool
#4
Laura Kerosuo, Marianne E Bronner
The neural crest is a transient embryonic population that originates within the central nervous system (CNS) and then migrates into the periphery and differentiates into multiple cell types. The mechanisms that govern neural crest stem-like characteristics and self-renewal ability are poorly understood. Here, we show that the proto-oncogene cMyc is a critical factor in the chick dorsal neural tube, where it regulates the size of the premigratory neural crest stem cell pool. Loss of cMyc dramatically decreases the number of emigrating neural crest cells due to reduced self-renewal capacity, increased cell death, and shorter duration of the emigration process...
December 6, 2016: Cell Reports
https://www.readbyqxmd.com/read/27926619/professional-governance-another-new-concept
#5
Robert G Hess
No abstract text is available yet for this article.
January 2017: Journal of Nursing Administration
https://www.readbyqxmd.com/read/27926536/a-minimal-titration-model-of-the-mammalian-dynamical-heat-shock-response
#6
Aude Sivéry, Emmanuel Courtade, Quentin Thommen
Environmental stress, such as oxidative or heat stress, induces the activation of the heat shock response (HSR) and leads to an increase in the heat shock proteins (HSPs) level. These HSPs act as molecular chaperones to maintain cellular proteostasis. Controlled by highly intricate regulatory mechanisms, having stress-induced activation and feedback regulations with multiple partners, the HSR is still incompletely understood. In this context, we propose a minimal molecular model for the gene regulatory network of the HSR that reproduces quantitatively different heat shock experiments both on heat shock factor 1 (HSF1) and HSPs activities...
December 7, 2016: Physical Biology
https://www.readbyqxmd.com/read/27926457/modulation-of-brain-pufa-content-in-different-experimental-models-of-mice
#7
Corinne Joffre, Stéphane Grégoire, Véronique De Smedt, Niyazi Acar, Lionel Bretillon, Agnès Nadjar, Sophie Layé
The relative amounts of arachidonic acid (AA) and docosahexaenoic acid (DHA) govern the different functions of the brain. Their brain levels depend on structures considered, on fatty acid dietary supply and the age of animals. To have a better overview of the different models available in the literature we here compared the brain fatty acid composition in various mice models (C57BL/6J, CD1, Fat-1, SAMP8 mice) fed with different n-3 PUFA diets (deficient, balanced, enriched) in adults and aged animals. Our results demonstrated that brain AA and DHA content is 1) structure-dependent; 2) strain-specific; 3) differently affected by dietary approaches when compared to genetic model of PUFA modulation; 4) different in n-3 PUFA deficient aged C57BL6/J when compared to SAMP8 mouse model of aging...
November 2016: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/27926446/how-motivation-and-reward-learning-modulate-selective-attention
#8
A Bourgeois, L Chelazzi, P Vuilleumier
Motivational stimuli such as rewards elicit adaptive responses and influence various cognitive functions. Notably, increasing evidence suggests that stimuli with particular motivational values can strongly shape perception and attention. These effects resemble both selective top-down and stimulus-driven attentional orienting, as they depend on internal states but arise without conscious will, yet they seem to reflect attentional systems that are functionally and anatomically distinct from those classically associated with frontoparietal cortical networks in the brain...
2016: Progress in Brain Research
https://www.readbyqxmd.com/read/27925755/collective-molecular-superrotation-a-model-for-extremely-flexible-molecules-applied-to-protonated-methane
#9
Hanno Schmiedt, Per Jensen, Stephan Schlemmer
The concept of molecular structure is traditionally considered to be virtually fundamental. However, it breaks down in extremely flexible molecules, whose dynamics are governed by large-amplitude motions. For the dynamics of molecules with free internal rotations, we therefore propose a five-dimensional rigid rotor model, with states characterized by two generalized angular momentum quantum numbers and a rotational constant B. The quantum numbers characterize a 5D angular-momentum vector, super-j, which describes collective rotations that involve both the internal and the overall rotation...
November 25, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27925669/biochemical-biophysical-and-cellular-techniques-to-study-the-guanine-nucleotide-exchange-factor-giv-girdin
#10
Pradipta Ghosh, Nicolas Aznar, Lee Swanson, I-Chung Lo, Inmaculada Lopez-Sanchez, Jason Ear, Cristina Rohena, Nicholas Kalogriopoulos, Linda Joosen, Ying Dunkel, Nina Sun, Peter Nguyen, Deepali Bhandari
Canonical signal transduction via heterotrimeric G proteins is spatiotemporally restricted, i.e., triggered exclusively at the plasma membrane, only by agonist activation of G protein-coupled receptors via a finite process that is terminated within a few hundred milliseconds. Recently, a rapidly emerging paradigm has revealed a noncanonical pathway for activation of heterotrimeric G proteins via the nonreceptor guanidine-nucleotide exchange factor, GIV/Girdin. Biochemical, biophysical, and functional studies evaluating this pathway have unraveled its unique properties and distinctive spatiotemporal features...
December 7, 2016: Current Protocols in Chemical Biology
https://www.readbyqxmd.com/read/27925570/nurse-apprentices-won-t-solve-workforce-shortage
#11
Stephanie Jones-Berry
The government's planned nursing degree apprenticeships represent a 'drop in the ocean' and will not solve the nursing workforce shortage, say nurse academics.
December 7, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27925569/focus-is-on-our-doctors
#12
James Buchan
With around one in three NHS doctors having been trained in another country, the headline-grabber at the Conservative party conference in October was the government's commitment to NHS England becoming 'self-sufficient' in doctors. Funding for the projected 15% increase in the number of medical students will come from the Department of Health's existing budget.
December 7, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27925568/letter
#13
Embashire
The government needs to understand that nurses join agencies to get the salary they deserve. When will they realise continuing pay restraint is a false economy?
December 7, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27925567/a-valued-profession
#14
Leigh Hughes
Re your online article 'RCN calls government response to pay petition completely inadequate', I agree nurses have been given a poor deal.
December 7, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27925537/nursing-takes-backward-step
#15
Veronica Burton
No one should have any part in the government's plans for associate nurses - or 'nurses on the cheap', as they undoubtedly are. And the plan for nursing degree apprenticeships is a retrograde step. Was the fight for degree-entry nursing a waste of time?
December 7, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27925534/plans-to-train-more-clinician-managers
#16
(no author information available yet)
More nurses and doctors will be encouraged to run hospitals in England, under new training schemes announced by the government.
December 7, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27925441/anodized-3d-printed-titanium-implants-with-dual-micro-and-nano-scale-topography-promote-interaction-with-human-osteoblasts-and-osteocyte-like-cells
#17
Karan Gulati, Matthew Prideaux, Masakazu Kogawa, Luis Lima-Marques, Gerald J Atkins, David M Findlay, Dusan Losic
The success of implantation of materials into bone is governed by effective osseointegration, requiring biocompatibility of the material and the attachment and differentiation of osteoblastic cells. To enhance cellular function in response to the implant surface, micro- and nano-scale topography have been suggested as essential. In this study, we present bone implants based on 3D-printed titanium alloy (Ti6Al4V), with a unique dual topography composed of micron-sized spherical particles and vertically aligned titania nanotubes...
December 7, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27925315/social-preferences-for-the-design-of-biodiversity-offsets-for-shorebirds-in-australia
#18
Abbie A Rogers, Michael P Burton
Understanding the social acceptability of biodiversity offsets is important in order to properly design offset policy. This study used a discrete choice experiment to quantify preferences of the Australian people for a migratory shorebird offset, in the context of an oil and gas development. We used both current and prospective offset policy characteristics, with a view to informing future policy design of the social dimensions related to offset acceptability. We found that the practice of offsetting was accepted by the community as a means to allow economic development...
December 7, 2016: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/27925270/incidence-and-prevalence-of-childhood-onset-type-1-diabetes-in-japan-the-t1d-study
#19
Y Onda, S Sugihara, T Ogata, S Yokoya, T Yokoyama, N Tajima
AIMS: A majority of children with Type 1 diabetes in Japan are registered with the government-subsidized Specified Pediatric Chronic Disease Treatment Research Projects (SPCDTRP). In this study, the incidence and prevalence of childhood-onset (< 15 years) Type 1 diabetes in Japan were estimated by drawing on SPCDTRP data. METHODS: Data available for 2005-2012 from the SPCDTRP and Statistics Bureau, Ministry of Internal Affairs and Communications were used to estimate the incidence of Type 1 diabetes for 2005-2010, adjusted to cover those registered within 3 years of disease onset and stratified by sex, age at onset and period of onset...
December 7, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27925181/estimation-of-the-tumor-size-at-cure-threshold-among-aggressive-non-small-cell-lung-cancers-nsclcs-evidence-from-the-surveillance-epidemiology-and-end-results-program-seer-and-the-national-lung-screening-trial-nlst
#20
Deborah L Goldwasser
The National Lung Screening Trial (NLST) demonstrated that non-small cell lung cancer (NSCLC) mortality can be reduced by a program of annual CT screening in high-risk individuals. However, CT screening regimens and adherence vary, potentially impacting the lung cancer mortality benefit. We defined the NSCLC cure threshold as the maximum tumor size at which a given NSCLC would be curable due to early detection. We obtained data from 518,234 NSCLCs documented in the U.S. SEER cancer registry between 1988 and 2012 and 1,769 NSCLCs detected in the NLST...
December 7, 2016: International Journal of Cancer. Journal International du Cancer
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