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https://www.readbyqxmd.com/read/28449418/hif-prolyl-hydroxylases-as-therapeutic-targets-in-erythropoiesis-and-iron-metabolism
#1
REVIEW
Volker H Haase
A classic response to systemic hypoxia is the increase in red blood cell production. This response is controlled by the prolyl hydroxylase domain/hypoxia-inducible factor (HIF) pathway, which regulates a broad spectrum of cellular functions. The discovery of this pathway as a key regulator of erythropoiesis has led to the development of small molecules that stimulate the production of endogenous erythropoietin and enhance iron metabolism. This review provides a concise overview of the cellular and molecular mechanisms that govern HIF-induced erythropoietic responses and provides an update on clinical experience with compounds that target HIF-prolyl hydroxylases for anemia therapy...
June 2017: Hemodialysis International
https://www.readbyqxmd.com/read/28449350/scandiatransplant-acceptable-mismatch-program-stamp-a-bridge-to-transplanting-highly-immunized-patients
#2
P Koefoed-Nielsen, I Weinreich, M Bengtsson, J Lauronen, C Naper, M Gäbel, S S Sørensen, L Wennberg, A V Reisaeter, B K Møller
BACKGROUND: Highly immunized patients are a challenge for organ transplantation programs. One way of increasing the likelihood of transplantation in this group of patients is to expand the possible donations by defining acceptable HLA mismatches. In the Scandiatransplant Acceptable Mismatch Program (STAMP), a de-centralized approach has been implemented in 2009. AIMS: The program has been improved during the years from utilizing HLA-A, -B, -DR matching only to include typing of all deceased donors for HLA-A, -B, -C, -DRB1 and -DQB1...
April 27, 2017: HLA
https://www.readbyqxmd.com/read/28449120/sigseeker-a-peak-calling-ensemble-approach-for-constructing-epigenetic-signatures
#3
Jens Lichtenberg, Laura Elnitski, David M Bodine
Motivation: Epigenetic data are invaluable when determining the regulatory programs governing a cell. Based on use of next-generation sequencing data for characterizing epigenetic marks and transcription factor binding, numerous peak-calling approaches have been developed to determine sites of genomic significance in these data. Such analyses can produce a large number of false positive predictions, suggesting that sites supported by multiple algorithms provide a stronger foundation for inferring and characterizing regulatory programs associated with the epigenetic data...
April 25, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28449115/estimation-of-state-level-prevalence-of-hepatitis-c-virus-infection-us-states-and-district-of-columbia-2010
#4
Eli S Rosenberg, Eric W Hall, Patrick S Sullivan, Travis H Sanchez, Kimberly A Workowski, John W Ward, Deborah Holtzman
Background.: Hepatitis C virus (HCV) infection is the most common chronic blood-borne infection in the United States and a leading cause of morbidity and mortality. Previous analyses of the US National Health and Nutrition Examination Survey (NHANES) indicated approximately 3.6 million noninstitutionalized persons with antibody to HCV (anti-HCV). However, state-level prevalence remains less understood and cannot be estimated reliably from NHANES alone. Methods.: We used 3 publicly available government data sources to estimate anti-HCV prevalence in each US state among noninstitutionalized persons aged ≥18 years...
April 26, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28449054/i-learn-therefore-i-am-a-phenomenological-analysis-of-meanings-of-lifelong-learning-for-vulnerable-older-adults
#5
Miya Narushima, Jian Liu, Naomi Diestelkamp
Background and Objectives: This study explores the lifelong learning experience of vulnerable older adults to find out (a) what is involved in their activities, (b) what meanings they take from their learning, and (c) how participation in a learning program helps to maintain their well-being and independent living despite their daily challenges. Research Design and Methods: This study employed a hermeneutic phenomenological approach. As part of a larger study, we conducted semi-structured interviews with older learners enrolled in general interest courses at a public continuing education program...
April 26, 2017: Gerontologist
https://www.readbyqxmd.com/read/28448950/promoting-innovation-in-small-markets-evidence-from-the-market-for-rare-and-intractable-diseases
#6
Toshiaki Iizuka, Gyo Uchida
In many medical care markets with limited profit potential, firms often have little incentive to innovate. These include the market for rare diseases, "neglected" tropical diseases, and personalized medicine. Governments and not-for-profit organizations promote innovation in such markets but empirical evidence on the policy effect is limited. We study this issue by analyzing the impact of a demand-side policy in Japan, which reduces the cost sharing of patients with some rare and intractable diseases and attempts to establish and promote the treatment of those diseases...
April 1, 2017: Journal of Health Economics
https://www.readbyqxmd.com/read/28448825/health-policy-in-the-concertaci%C3%A3-n-era-1990-2010-reforms-the-chilean-way
#7
María Soledad Martinez-Gutierrez, Cristóbal Cuadrado
The Chilean health system has experienced important transformations in the last decades with a neoliberal turn to privatization of the health insurance and healthcare market since the Pinochet reforms of the 1980s. During 20 years of center-left political coalition governments several reforms were attempted to regulate and reform such markets. This paper analyzes regulatory policies for the private health insurance and health care delivery market, adopted during the 1990-2010 period. A framework of variation in market types developed by Gingrich is adopted as analytical perspective...
April 9, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28448628/determinants-of-formal-care-use-and-expenses-among-in-home-elderly-in-jing-an-district-shanghai-china
#8
Fen Li, Xinye Fang, Jiechun Gao, Hansheng Ding, Changying Wang, Chunyan Xie, Yitong Yang, Chunlin Jin
The need for formal care among the elderly population has been increasing due to their greater longevity and the evolution of family structure. We examined the determinants of the use and expenses of formal care among in-home elderly adults in Shanghai. A two-part model based on the data from the Shanghai Long-Term Care Needs Assessment Questionnaire was applied. A total of 8428 participants responded in 2014 and 7100 were followed up in 2015. The determinants of the probability of using formal care were analyzed in the first part of the model and the determinants of formal care expenses were analyzed in the second part...
2017: PloS One
https://www.readbyqxmd.com/read/28448612/hydrodynamic-characteristics-of-submerged-vegetation-flow-with-non-constant-vertical-porosity
#9
Mingdeng Zhao, Zilong Fan
In order to investigate the influence of the vertical variation of porosity on open-channel flow with submerged vegetation, vertical non-homogeneous stumps and stems in submerged vegetation flow are simulated with truncated cones in a laboratory flume. First, porosity is defined as a function of water depth. A new governing equation for vegetation flow is established on the basis of the poroelastic media flow theory, and its analytical solution is obtained with the finite analytic method. Then, the fitting expression of permeability is established with experimental data, which shows the variation in permeability with vertical porosity and vegetation density...
2017: PloS One
https://www.readbyqxmd.com/read/28448488/the-potential-economic-burden-of-zika-in-the-continental-united-states
#10
Bruce Y Lee, Jorge A Alfaro-Murillo, Alyssa S Parpia, Lindsey Asti, Patrick T Wedlock, Peter J Hotez, Alison P Galvani
BACKGROUND: As the Zika virus epidemic continues to spread internationally, countries such as the United States must determine how much to invest in prevention, control, and response. Fundamental to these decisions is quantifying the potential economic burden of Zika under different scenarios. METHODOLOGY/PRINCIPLE FINDINGS: To inform such decision making, our team developed a computational model to forecast the potential economic burden of Zika across six states in the US (Alabama, Florida, Georgia, Louisiana, Mississippi, and Texas) which are at greatest risk of Zika emergence, under a wide range of attack rates, scenarios and circumstances...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28448326/design-of-an-online-medication-safety-module-for-clinicians
#11
Hanan Khalil, Kirsten Schliephake
BACKGROUND: In Australia, there are very few online courses addressing medication safety issues. Educating clinicians about medication safety is paramount given the increased responsibility of clinicians in advanced practice roles including nurses at several key points throughout the medication process that encompass prescribing, dispensing, administering and monitoring medications. METHOD: The model used for the course design is based on adult teaching principles...
April 26, 2017: International Journal of Evidence-based Healthcare
https://www.readbyqxmd.com/read/28448253/a-map-of-abstract-relational-knowledge-in-the-human-hippocampal-entorhinal-cortex
#12
Mona M Garvert, Raymond J Dolan, Timothy Ej Behrens
The hippocampal-entorhinal system encodes a map of space that guides spatial navigation. Goal-directed behaviour outside of spatial navigation similarly requires a representation of abstract forms of relational knowledge. This information relies on the same neural system, but it is not known whether the organisational principles governing continuous maps may extend to the implicit encoding of discrete, non-spatial graphs. Here, we show that the human hippocampal-entorhinal system can represent relationships between objects using a metric that depends on associative strength...
April 27, 2017: ELife
https://www.readbyqxmd.com/read/28448200/better-together-the-making-and-maturation-of-the-palliative-care-research-cooperative-group
#13
Christine L Ritchie, Kathryn I Pollak, Karen A Kehl, Jeri L Miller, Jean S Kutner
OBJECTIVE: To describe the growth and outcomes of the Palliative Care Research Cooperative Group (PCRC). BACKGROUND: Despite advances, significant gaps remain in the evidence base to inform care for people with serious illness. To generate this needed evidence and bolster research capacity, the Palliative Care Research Cooperative (PCRC) group was formed. METHODS: The PCRC supports investigators in the conduct of multisite clinical studies...
April 27, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28448162/joblessness-and-lost-earnings-after-ards-in-a-1-year-national-multicenter-study
#14
Biren B Kamdar, Minxuan Huang, Victor D Dinglas, Elizabeth Colantuoni, Till M von Wachter, Ramona O Hopkins, Dale M Needham
RATIONALE: Following acute respiratory distress syndrome (ARDS), joblessness is common, but poorly understood. OBJECTIVES: To evaluate the timing of return to work following ARDS, and associated risk factors, lost earnings, and changes in healthcare coverage Methods: Over 12-month longitudinal follow-up, ARDS survivors from 43 U.S. ARDSNet hospitals provided employment and healthcare coverage data via structured telephone interviews. Factors associated with the timing of return to work were assessed using Fine and Gray regression analysis...
April 27, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28448139/suppression-of-nitrite-oxidizing-bacteria-in-intermittently-membrane-aerated-biofilms-a-model-based-explanation
#15
Yunjie Ma, Carlos Domingo-Félez, Benedek Gy Plosz, Barth F Smets
Autotrophic ammonium oxidation in membrane-aerated biofilm reactors (MABRs) can make treatment of ammonium-rich wastewaters more energy-efficient, especially within the context of short-cut ammonium removal. The challenge is to exclusively enrich ammonium-oxidizing bacteria (AOB). To achieve nitritation, strategies to suppress nitrite-oxidizing bacteria (NOB) are needed, which are ideally grounded on an understanding of underlying mechanisms. In this study, a counter-diffusion nitrifying biofilm reactor was operated under intermittent aeration...
April 27, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28447899/the-american-college-of-surgeons-minimum-standards-for-hospitals-and-the-provision-of-high-quality-laboratory-services
#16
James R Wright
CONTEXT: - The first major project of the American College of Surgeons (Chicago, Illinois), founded in 1913, was implementing Minimum Standards for Hospitals. The 1918 standard (1) established medical staff organizations in hospitals; (2) restricted membership to licensed practitioners in good standing; (3) mandated that the medical staff work with hospital administration to develop and adopt regulations and policies governing their professional work; (4) required standardized, accessible medical records; and (5) required availability of diagnostic and therapeutic facilities...
May 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28447823/the-promise-of-demand-side-employer-based-strategies-to-increase-employment-rates-for-people-living-with-serious-mental-illnesses
#17
Jonathan Delman, Lynn Kovich, Sara Burke, Kevin Martone
OBJECTIVE: This article describes current and promising demand-side strategies to increase job retention and employment rates of people living with serious mental illnesses. The article raises awareness of the potential impact of demand side strategies and generates considerations to implement and evaluate these strategies. METHOD: Information is drawn from peer reviewed research, policy articles and documents, and the authors' direct experiences. RESULTS: Employees with serious mental illnesses struggle to retain jobs due to workplace stigma, difficulty accessing reasonable accommodations, and noneligibility for health benefits...
April 27, 2017: Psychiatric Rehabilitation Journal
https://www.readbyqxmd.com/read/28447695/phase-transformation-of-tio2-nanoparticles-by-femtosecond-laser-ablation-in-aqueous-solutions-and-deposition-on-conductive-substrates
#18
Paola Russo, Robert Liang, Rui Xiu He, Y Norman Zhou
Titanium dioxide (TiO2) is a wide bandgap semiconductor that is chemically stable, non-toxic, and economical compared to other semiconductors and has been implemented in a wide range of applications such as photocatalysis, photovoltaics, and memristors. In this work we studied the femtosecond laser ablation of titanium dioxide powders (P25) dispersed either in water or deposited onto a fluoride-doped tin oxide (FTO) substrate. The process was used as a route to induce the phase-transformation of TiO2 nanoparticles which was governed by laser parameters such as ablation time and power...
April 27, 2017: Nanoscale
https://www.readbyqxmd.com/read/28447689/chemodynamics-of-metal-ion-complexation-by-charged-nanoparticles-a-dimensionless-rationale-for-soft-core-shell-and-hard-particle-types
#19
Jérôme F L Duval
Soft nanoparticulate complexants are defined by a spatial confinement of reactive sites and electric charges inside their 3D body. In turn, their reactivity with metal ions differs significantly from that of simple molecular ligands. A revisited form of the Eigen mechanism recently elucidated the processes leading to metal/soft particle pair formation. Depending on e.g. particle size and metal ion nature, chemodynamics of nanoparticulate metal complexes is controlled by metal conductive diffusion to/from the particles, by intraparticulate complex formation/dissociation kinetics, or by both...
April 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28447677/investigation-of-easy-plane-magnetic-anisotropy-in-p-ligand-square-pyramidal-co-ii-single-ion-magnets
#20
Amit Kumar Mondal, Jesús Jover, Eliseo Ruiz, Sanjit Konar
In this work we report two pentacoordinated Co(II)-P4X1 Single Ion Magnets (SIMs) based on P-donor ligands. The tetradentate ligand tris[2-(diphenylphosphino)ethyl]phosphine allows the obtention of the isostructural square pyramidal [Co(PP3)Cl]·ClO4 (1) and [Co(PP3)Br]·ClO4 (2) complexes. Consistent theoretical and experimental studies indicate that these complexes have a high spin (S = 3/2) ground state and suggest that the relaxation dynamics is governed by ground state quantum tunneling, whereas its temperature dependence is directed by optical or acoustic Raman processes...
April 27, 2017: Chemical Communications: Chem Comm
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