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https://www.readbyqxmd.com/read/28429517/primary-laryngeal-sarcomas-in-a-mexican-population-case-series-of-eleven-cases
#1
Kuauhyama Luna-Ortiz, Sarina Navarro-Santiesteban, Veronica Villavicencio-Valencia, Rosa A Salcedo-Hernandez, Leonardo S Lino-Silva, Juan A Delgado
Sarcomas are mesenchymal tumors that represent 1% of malignant diseases in humans. Of these, 4-10% occur in the head and neck and only <1% occur in the larynx.(1) These groups of neoplasms have a wide range of histological variants and, accordingly, their clinical behavior varies widely, from slow-growing, relatively circumscribed tumors, to rapidly growing, locally invasive malignancies. In addition, the heterogeneity of the location of the laryngeal anatomic sub-sites require special therapeutic considerations...
April 21, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28420520/the-association-of-enchondromatosis-with-malignant-transformed-chondrosarcoma-and-ovarian-juvenile-granulosa-cell-tumor-ollier-disease
#2
Andrea Burgetova, Zdenek Matejovsky, Michal Zikan, Jiri Slama, Pavel Dundr, Petr Skapa, Kamila Benkova, David Cibula, Daniela Fischerova
OBJECTIVE: Ovarian juvenile granulosa cell tumor has an interesting association with multiple enchondromatosis (Ollier disease and Maffucci syndrome) and should be considered a leading diagnosis when an ovarian mass is found in young patients with these conditions. Besides the association with nonskeletal malignancies, there is a high risk of malignant transformation of enchondroma in chondrosarcoma as was also the case in this instance. CASE REPORT: The report uses multiple images to document the representative and characteristic markers of multiple enchondromas in a 22-year-old patient with Ollier disease complicated by malignant transformation of chondrosarcoma and in whom the disease is associated with ovarian juvenile granulosa cell tumor of the right ovary...
April 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28420036/dedifferentiated-chondrosarcoma-a-survival-analysis-of-159-cases-from-the-seer-database-2001-2011
#3
Patrick K Strotman, Taylor J Reif, Stephanie A Kliethermes, Jasmin K Sandhu, Lukas M Nystrom
BACKGROUND AND OBJECTIVES: Dedifferentiated chondrosarcoma is a rare malignancy with reported 5-year overall survival rates ranging from 7% to 24%. The purpose of this investigation is to determine the overall survival of dedifferentiated chondrosarcoma in a modern patient series and how it is impacted by patient demographics, tumor characteristics, and surgical treatment factors. METHODS: This is a retrospective review of the Surveillance, Epidemiology, and End Results (SEER) database from 2001 to 2011...
April 18, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28411397/chondrosarcoma-like-metastasis-from-a-poorly-differentiated-uterine-cervical-squamous-cell-carcinoma-a-unique-morphology-and-diagnostic-pitfall-in-cytology
#4
Shohei Ikoma, Marlo Nicolas, Jaishree Jagirdar, Maria Luisa Policarpio-Nicolas
Rare cases of metastatic squamous cell carcinoma with chondroid differentiation from esophageal primary have been reported but none from the uterine cervix. Given the rarity of this phenomenon and potential diagnostic pitfall, we present this unusual case. The patient is a 25-year-old woman who presented with shortness of breath. Computerized tomography (CT) showed several lung and pleural-based nodules. CT-guided core biopsy with touch preparations were performed on the pleural-based nodule. The touch preparations showed large, spindle-to-oval shaped cells with pleomorphic nuclei embedded in metachromatic chondroid stroma...
April 14, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28402910/skin-nipple-sparing-mastectomy-the-first-approach-in-primary-myxoid-chondrosarcoma-of-the-breast
#5
G Militello, G Zabbia, A Mascolino, K Kabhuli, E Gulotta, P De Marco, F Incandela, G Scerrino, G Gulotta
The primary mammary chondrosarcoma corresponds to less than 0,5% of the mammary malignancies. For the period ranging from 1967 to 2014, only 18 cases were reported in the literature. A 41year old woman found a hard nodule on her external right superior quadrant/axillary prolongation through breast self-examination. The vacuum-assisted core biopsy (VACB) revealed "high grade extra-skeletal myxoid chondrosarcoma". A skin-nipple-sparing mastectomy with the insertion of a mammary expander was performed. A protocol of adjuvant radiotherapy was also indicated...
March 22, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28397585/survival-and-margin-status-in-head-and-neck-radiation-induced-sarcomas-and-de-novo-sarcomas
#6
Andrew J Rosko, Andrew C Birkeland, Steven B Chinn, Andrew G Shuman, Mark E Prince, Rajiv M Patel, Jonathan B McHugh, Matthew E Spector
Objective To describe histologic subtypes and oncologic outcomes among patients with radiation-induced and de novo sarcomas of the head and neck. Study Design Retrospective case series with chart review. Setting Tertiary academic center. Subject and Methods In total, 166 adult patients with sarcoma of the head and neck treated from January 1, 1985, to January 1, 2010, were included. Tumors were characterized as radiation induced (15.1%) vs de novo sarcomas (84.9%). Clinical and tumor characteristics were compared...
April 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28389822/erratum-to-periosteal-mesenchymal-chondrosarcoma-of-the-tibia-with-multifocal-bone-metastases-a-case-report
#7
Rajendra Kumar, Cihan Duran, Behrang Amini, Dejka M Araujo, Wei-Lien Wang
No abstract text is available yet for this article.
April 8, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28383167/hspa8-as-a-novel-fusion-partner-of-nr4a3-in-extraskeletal-myxoid-chondrosarcoma
#8
Milena Urbini, Annalisa Astolfi, Maria Abbondanza Pantaleo, Salvatore Serravalle, Angelo Paolo Dei Tos, Piero Picci, Valentina Indio, Marta Sbaraglia, Stefania Benini, Alberto Righi, Marco Gambarotti, Alessandro Gronchi, Chiara Colombo, Gian Paolo Dagrada, Silvana Pilotti, Roberta Maestro, Maurizio Polano, Maristella Saponara, Giuseppe Tarantino, Andrea Pession, Guido Biasco, Paolo Giovanni Casali, Silvia Stacchiotti
Extraskeletal myxoid chondrosarcoma (EMC) is a very rare sarcoma most often arising in the soft tissue. Rare EMC of the bone have been reported. EMC exhibits distinctive clinico-pathological and genetic features; however, despite the name, it lacks any feature of cartilaginous differentiation. EMC is characterized by the rearrangement of the NR4A3, which, in most cases (about 62-75%), is fused with EWSR1 and less frequently with other partners, including TAF15 (27%), TCF12 (4%), TFG and FUS. We herein report the identification by whole-transcriptome sequencing of HSPA8 as a novel fusion partner of NR4A3 in a case of EMC...
April 6, 2017: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/28378427/comparative-assessment-of-the-accuracy-of-cytological-and-histologic-biopsies-in-the-diagnosis-of-canine-bone-lesions
#9
S Sabattini, A Renzi, P Buracco, S Defourny, M Garnier-Moiroux, O Capitani, G Bettini
BACKGROUND: Osteosarcoma (OSA) should be differentiated from other less frequent primary bone neoplasms, metastatic disease, and tumor-like lesions, as treatment and prognosis can vary accordingly. Hence, a preoperative histologic diagnosis is generally preferred. This requires collection of multiple biopsies under general anesthesia, with possible complications, including pathological fractures. Fine-needle aspiration cytology would allow an earlier diagnosis with a significant reduction of discomfort and morbidity...
April 4, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28360467/curious-case-of-extraskeletal-myxoid-chondrosarcoma
#10
Sushilkumar Satish Gupta, Neha Khanna, Adam Jacobi
Extraskeletal myxoid chondrosarcomas (EMC) are a rare entity of soft tissue tumors that have slow growth with metastatic potential. We discuss here a case of EMC presenting with right upper extremity pain and hemoptysis. Computed tomography scans chest showed diffuse metastatic numerous lung nodules bilaterally. Biopsy confirmed the diagnosis of the tumor. Chemotherapy was a bigger challenge for our patient due to sparse research and data in the literature about the disease.
March 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28352960/periosteal-mesenchymal-chondrosarcoma-of-the-tibia-with-multifocal-bone-metastases-a-case-report
#11
Rajendra Kumar, Cihan Duran, Behrang Amini, Dejka M Araujo, Wi-Lei Wang
Mesenchymal chondrosarcoma of bone is a rare high-grade variant of chondrosarcoma, which typically has central intramedullary location. The tumor is characterized by admixture of highly anaplastic small round malignant cells and islands of mineralized low-grade hyaline cartilage. It is most unusual for this tumor to arise on the surface of a long bone. We describe a patient with periosteal mesenchymal chondrosarcoma that arose at the surface of the right tibia with multifocal bone metastases. Radiographic, CT, MRI, and PET-CT features of this unusual tumor are presented...
March 28, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28303203/a-case-of-acute-subdural-hematoma-due-to-bleeding-from-metastatic-chondrosarcoma-of-the-skull
#12
Kenzo Kosugi, Satoshi Takahashi, Hikaru Sasaki, Ryota Tamura, Kentaro Ohara, Kazunari Yoshida
BACKGROUND: Intra or peritumoral hemorrhage of brain and skull tumors sometimes presents as stroke. Skull metastasis of chondrosarcoma is relatively rare, and furthermore, a case of intratumoural hemorrhage of skull metastasis of chondrosarcoma has not been reported. CASE DESCRIPTION: A 73-year-old man underwent right lower leg amputation in the past because of chondrosarcoma and was operated for a skull metastasis. He presented with a sudden headache, and head computed tomography revealed a right acute subdural hematoma (SDH) adjacent to the recurrent skull metastatic tumor...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28301537/dedifferentiated-chondrosarcoma-radiological-features-prognostic-factors-and-survival-statistics-in-23-patients
#13
Chenglei Liu, Yan Xi, Mei Li, Qiong Jiao, Huizhen Zhang, Qingcheng Yang, Weiwu Yao
BACKGROUND: Dedifferentiated chondrosarcoma is a rare, highly malignant tumor with a poor survival. There are many confusing issues concerning the imaging feature that can facilitate early diagnosis and the factors that might be related to outcomes. METHODS: Twenty-three patients with dedifferentiated chondrosarcoma confirmed by pathology were retrospectively reviewed from 2008 to 2015. The patients' clinical information, images from radiographs (n = 17), CT (n = 19), and MRI (n = 17), histological features, treatment and prognosis were analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28271053/renal-extra-skeletal-mesenchymal-chondrosarcoma-a-case-report
#14
Mehdi Salehipour, Masood Hosseinzadeh, Afshin Molaei Sisakhti, Vahid Abdol Mohammadi Parvin, Amin Sadraei, Ali Adib
Primary mesenchymal chondrosarcoma of the Kidney is an extremely rare entity and very few cases have been reported in literature. We report a 22-year-old male with a right renal mass; after radical nephrectomy, pathologic examination revealed primary extra skeletal mesenchymal chondrosarcoma.
May 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28258179/extraskeletal-orbital-mesenchymal-chondrosarcoma-surgical-approach-and-mini-review
#15
REVIEW
Ashish Jakhetiya, Nootan Kumar Shukla, Dillip Muduly, Shashank S Kale
Extraskeletal orbital mesenchymal chondrosarcoma (MC) is an extremely rare and highly aggressive tumour. It has characteristic radiological features and pathognomic histological biphasic pattern. Radical resection with negative margins is the mainstay of treatment; role of adjuvant chemotherapy and radiotherapy is yet not well defined. We report a rare case of 18-year-old man who was diagnosed to have orbital MC. He presented with locally advanced disease with no vision in the affected eye. He underwent right orbital exenteration; a transcranial intradural approach was used to divide the optic nerve, and the temporalis muscle flap was utilised to fill the exenterated orbit...
March 3, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28255973/chondromyxoid-fibroma-of-the-skull-base-our-experience-with-an-elusive-disease
#16
Giancarlo D'Andrea, Alessandro Pesce, Guido Trasimeni, Venceslao Wierzbicki, Veronica Picotti, Alessandra Serraino, Riccardo Caruso
Chondromyxoid fibroma (CMF) is an extremely rare lesion of the skull base. This histologic type typically predilects metaphysis of the long bones. It is locally invasive/infiltrative, and this tendency is more concerning in the skull base, where a radical resection is often technically impossible because of the presence of vital neurovascular structures. We present a case of a 19-year-old woman who presented with a sudden onset of right facial weakness, progressively worsening to a severe disfiguring motor weakness...
March 2, 2017: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/28249774/primary-extraskeletal-myxoid-chondrosarcoma-of-bone-report-of-three-cases-and-review-of-the-literature
#17
L Finos, A Righi, T Frisoni, M Gambarotti, C Ghinelli, S Benini, D Vanel, P Picci
Extraskeletal myxoid chondrosarcoma is a rare neoplasm of soft tissue. The usual location is in deep parts of the proximal extremities and limb girdles in middle-aged adults. The bone location as primary location is extremely rare and few cases are reported. We present three cases arising in bone with molecular confirmation using both RT-PCR and FISH analysis. Patients include two men and one woman with an age of 62, 69 and 73 years old. The mean size of the lesion was 13cm (range 8-18cm). Tumors arose in the iliac bone in two cases and in the proximal humerus in the other case...
February 11, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28243595/cns-metastases-from-bone-and-soft-tissue-sarcomas-in-children-adolescents-and-young-adults-are-they-really-so-rare
#18
Monika Bekiesinska-Figatowska, Agnieszka Duczkowska, Marek Duczkowski, Hanna Bragoszewska, Anna Romaniuk-Doroszewska, Beata Iwanowska, Sylwia Szkudlinska-Pawlak, Jaroslaw Madzik, Katarzyna Bilska, Anna Raciborska
Purpose. To check whether primary involvement of brain/spinal cord by bone/soft tissue sarcomas' metastases in children is as rare as described and to present various morphological forms of bone/soft tissue sarcomas' CNS metastases. Methods. Patients with first diagnosis in 1999-2014 treated at single center were included with whole course of disease evaluation. Brain/spinal canal magnetic resonance imaging (MRI)/computed tomography were performed in cases suspicious for CNS metastases. Extension from skull/vertebral column metastases was excluded...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28239886/fibrocartilaginous-mesenchymoma-of-bone-a-single-institution-experience-with-molecular-investigations-and-a-review-of-the-literature
#19
Marco Gambarotti, Alberto Righi, Daniel Vanel, Stefania Cocchi, Stefania Benini, Francesca M Elli, Giovanna Mantovani, Pietro Ruggieri, Stefano Boriani, Davide M Donati, Marta Sbaraglia, Angelo P Dei Tos, Piero Picci
AIMS: Fibrocartilaginous mesenchymoma is a rare intraosseous lesion, with a total of 26 cases described in the literature. This study describes the clinical, radiological and histological features of eight new cases of fibrocartilaginous mesenchymoma collected at a single institution between 1982 and 2016. The presence of GNAS and IDH1/2 mutations and MDM2 amplification was explored to evaluate possible links between fibrocartilaginous mesenchymoma, fibrous dysplasia, de-differentiated chondrosarcoma and low-grade osteosarcoma...
February 26, 2017: Histopathology
https://www.readbyqxmd.com/read/28219175/-a-child-with-extraskeletal-mesenchymal-chondrosarcoma-in-nasal-cavity-and-sinus-a-case-report
#20
M Li, C B Guo, J Xing
No abstract text is available yet for this article.
February 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
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