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chondrosarcoma case

Matthias Benndorf, Jakob Neubauer, Mathias Langer, Elmar Kotter
PURPOSE: In the diagnostic process of primary bone tumors, patient age, tumor localization and to a lesser extent sex affect the differential diagnosis. We therefore aim to develop a pretest probability calculator for primary malignant bone tumors based on population data taking these variables into account. METHODS: We access the SEER (Surveillance, Epidemiology and End Results Program of the National Cancer Institute, 2015 release) database and analyze data of all primary malignant bone tumors diagnosed between 1973 and 2012...
October 8, 2016: International Journal of Computer Assisted Radiology and Surgery
Sumit Majumdar, Rajyalakshmi Boddepalli, Divya Uppala, A Kameswara Rao
Mesenchymal chondrosarcomas (MC) are rare and aggressive forms of chondrosarcoma. They are distinct tumors arising in unicentric or multicentric locations from both skeletal and extraskeletal tissues. The most affected region is the facial skeleton, especially the jaws. In this report, we present a case of MC primarily involving the mandible in a 60-year-old female patient.
September 2016: Journal of Oral and Maxillofacial Pathology: JOMFP
Nihat Demirhan Demirkiran, Olcay Akdeniz, Onur Hapa, Hasan Havıtçıoğlu
INTRODUCTION: Arthroscopic fixation of tibial spine fracture without damage to the growth plate is very important in patients with open physis. The present article describes a simple and effective technique being used for the first time to treat this condition. CASE REPORT: A 16-year-old boy sustained avulsion fractures of tibial spine while playing. He was treated arthroscopically with excellent result. CONCLUSION: Arthroscopic fixation of tibial spine fracture in patients with open physis with two cannulated screws perpendicular to each other is a very simple technique which provides strong construct, and allows early mobilization without risk of damage to the growth plate...
April 2016: Journal of Orthopaedic Case Reports
O B Pattanashetty, Dayanand B B, Arravind Pillai, Preetish Endigeri
INTRODUCTION: Dedifferentiated chondrosarcoma (DDCS) is a rare and malignant form of primary bone tumor refractive to chemotherapy and radiotherapy. It accounts for 1-2% of all primary bone tumors. Surgical resection, limb-salvage surgeries and amputation remain the mainstay of treatment. The prognosis of dedifferentiated chondrosarcoma is poor. CASE REPORT: We report a case of a 51-year-old male having a swelling and an ulcer distal to the left knee later diagnosed with dedifferentiated chondrosarcoma of proximal tibial and fibular metaphysis...
April 2016: Journal of Orthopaedic Case Reports
James Benjamin Gleason, Basheer Tashtoush, Maria Julia Diacovo
Biphasic malignant pleural mesothelioma is a rare malignant tumor, usually presenting as a pleural-based mass in a patient with history of chronic asbestos exposure. We herein report a case of a 41-year-old man who presented with chest pain and had a chest computed tomography (CT) scan suggestive of a primary skeletal tumor originating from the ribs (chondrosarcoma or osteosarcoma), with no history of asbestos exposure. CT-guided core needle biopsies were diagnosed as malignant sarcomatoid mesothelioma. Surgical resection and chest wall reconstruction were performed, confirming the diagnosis and revealing a secondary histologic component (epithelioid), supporting the diagnosis of biphasic malignant mesothelioma...
2016: Case Reports in Pulmonology
M Li, Y P Cai, K Y Lu, Y Chen, X Zhu, Y Yin, J Tang
Objective: To investigate the role of SATB2 in the pathological diagnosis and differential diagnosis of osteosarcoma. Methods: Immunostaining of SATB2 was performed in 47 cases of osteosarcomas, 5 osteoblastomas, 4 fibrous dysplasias, 5 myositis ossificans, 10 chondroblastomas, 8 chondrosarcomas, 5 Ewing sarcomas, 5 undifferentiated pleomorphic sarcomas, 6 fibrosarcomas and 2 leiomyosarcomas. Results: All osteoblastomas (5/5) and myositis ossificans (5/5), 83.0%(39/47) of osteosarcomas and 2/10 of chondroblastomas showed nuclear immunoreactivity for SATB2...
September 8, 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Xiaoning Guo, Tang Liu, Xiaoyang Li, Zhihong Li, Dan Peng, Xiangsheng Zhang, Qing Zhang
OBJECTIVE: To explore the efficacy of the resection of periacetabular malignant tumors and the reconstruction with modular endoprosthesis.
 METHODS: From August 2006 to December 2012, 22 patients with periacetabular malignant tumors, who received the resection and reconstruction with modular prosthesis, were retrospectively reviewed. There were 11 males and 11 females, and the average age was 44 (16-65) years old. Pathological results showed there were 13 cases of chondrosarcoma, 5 cases of osteosarcoma, 2 cases of Ewing's sarcoma, 1 case of maligant fibrous histiocytoma, and 1 case of giant cell tumor...
September 28, 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
Pedro David Delgado-López, Antonio Rodríguez-Salazar, Vicente Martín-Velasco, José Manuel Castilla-Díez, Javier Martín-Alonso, Ana Galacho-Harriero, Cecilia Gil-Polo, Elena Araus-Galdós
OBJECTIVE: To describe the specific surgical details and report the lessons learned with a series of patients suffering from spinal tumours that underwent total en bloc spondylectomy (TES). METHODS: A retrospective case series review is presented, together with an analysis of the clinical and technical variables, as well as the outcomes. RESULTS: A total of 10 patients underwent TES (2000-2016) for primary (osteosarcoma, chondrosarcoma, fibrosarcoma and chordoma) and secondary spinal tumours (lung, breast, thyroid, oesophagus, and meningioma metastases)...
September 14, 2016: Neurocirugía
P F P Roynard, A Bilderback, C Falzone, J D Stefanacci, G B Cherubini
OBJECTIVES: To report the clinical presentation, magnetic resonance imaging features, treatments and outcomes of canine vertebral chondrosarcoma. MATERIALS AND METHODS: Retrospective review of medical records of dogs with confirmed vertebral chondrosarcoma and magnetic resonance imaging of the lesions, from four different veterinary referral institutions. RESULTS: A total of six dogs were included in this report. In all cases, magnetic resonance imaging revealed a lobulated mass involving the dorsal vertebral compartment, markedly hyperintense with few foci of hypointensity on T2-weighted images, iso to hypointense on T1-weighted images with contrast enhancement after gadolinium administration...
September 14, 2016: Journal of Small Animal Practice
D Bian, J Y Wang, J Li, M Zhao
No abstract text is available yet for this article.
August 7, 2016: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
F Birsasteanu, D Costachescu
Maffucci syndrome (MS) is a very rare, non-hereditary dysplasia, manifested by multiple enchondromas and haemangiomas. Malignant transformation of these lesions is seen in up to 33% of the cases. There is also a very rare association with secondary musculoskeletal deformaties. We present a case of a patient with Maffucci syndrome and an associated chondrosarcoma of the scapula. Treatment consisted of surgical resection. Because of the low grade of the tumour (G1), additional treatment radiotherapy/chemotherapy), was not necessary...
October 20, 2015: West Indian Medical Journal
Ying Chen, Ying Zhang
This study describes a case of myxoid chondrosarcoma of the mandible in a 22-year-old male patient. A tumour in the buccal gingiva of the lower left premolar region had been identified 2 years earlier. Whole-jaw panoramic radiographs showed a hypodense shadow in the mesiodistal area near the roots of teeth 34 and 35. A maxillofacial computed tomography scan revealed a mass in the lower left premolar soft tissue, with a shadow indicating bone destruction, a clear boundary and uniform density. The preliminary diagnosis at the outpatient department was 34-35 epulis...
September 2016: Molecular and Clinical Oncology
Hongwei Liu, Xiuhong Chen, Teng Wan, Ren Li
Chondrosarcoma is a malignant tumor that is characterized by the formation of cartilage by tumor cells. The tumor is commonly observed in regions where cartilage is already present. In total, 5-12% of chondrosarcomas occur in the head and neck region. However, the occurrence of chondrosarcoma in the mental foramen region is extremely rare. The aim of the present study was to report a case of chondrosarcoma in the mental foramen region. An 18-year-old man presented with a 3-month history of a painless mass over the labial aspect of the right mandible, which was associated with the patient feeling unwell and the loosening of the lower anterior teeth...
September 2016: Oncology Letters
M Vlychou, J Teh, D Whitwell, N A Athanasou
Hibernoma is a benign adipose tumour that contains foetal brown fat cells. We report a case of hibernoma arising in the left ischium of a 65-year-old female with a past history of ovarian carcinoma. The patient presented with a relatively short history of left sacral/hip pain. Radiologically, the lesion, which was large (5 cm) and sclerotic, had been stable for a number of years. Histologically, it was composed mainly of plump cells with foamy, multivacuolated cytoplasm. These cells showed no reaction for epithelial, melanoma or leucocyte markers but expressed FABP4/aP2 and S100, indicating that they were brown fat cells...
November 2016: Skeletal Radiology
Jeremy R Child, Colin R Young, Behrang Amini
Liposarcoma is one of the most common soft-tissue sarcomas. Calcification and ossification can occur in liposarcoma; however, the presence of both ossification and calcification is a very rare entity. We present a case of a partially calcified and ossified dedifferentiated liposarcoma of the thigh in a 76-year-old woman, which contained heterologous elements of chondrosarcoma and rhabdomyosarcoma.
September 2016: Radiology case reports
Ricardo Balanzá, Rodrigo Arrangoiz, Fernando Cordera, Manuel Muñoz, Enrique Luque-de-León, Eduardo Moreno, Lourdes Molinar, Nicole Somerville
BACKGROUND: Extraskeletal myxoid chondrosarcoma (EMC) accounts for the 3% of all soft tissue sarcomas and it's categorized as a tumour of uncertain differentiation. This entity has shown to have the recurrent balanced chromosomal translocation t(9;22) (q22;q12.2), which leads to the oncogenic fusion gene EWSR1-NR4A3. This sarcoma usually presents as a slow growing, palpable mass in the extremities. EMC arising from the lung is extremely infrequent. We report one case of pulmonary extraskeletal mixoid chondrosarcoma and a review of the world literature...
2016: International Journal of Surgery Case Reports
Hai V Le, Rishi Wadhwa, Pierre Theodore, Praveen Mummaneni
Chondrosarcomas are cartilage-matrix-forming tumors that make up 20-27% of primary malignant bone tumors and are the third most common primary bone malignancy after multiple myelomas and osteosarcomas. Radiographic assessment of this condition includes plain radiography, computed tomography, and magnetic resonance imaging for tumor characterization and delineation of intraosseous and extraosseous involvement. Most chondrosarcomas are refractory to chemotherapy and radiation therapy; therefore, wide en bloc surgical excision offers the best chance for cure...
2016: Curēus
Xiangmin Shi, Zhuo Liang, Jian Li, Jianping Guo, Zhaoliang Shan, Yutang Wang
Ventricular tachycardia (VT) and premature contraction originating from the right ventricular outflow tract (RVOT) usually appear in healthy individuals. Radiofrequency ablation (RFA) is highly effective at resolving this type of arrhythmia. Refractory VT of RVOT is uncommon and occasionally results from cardiac metastasis of extraskeletal mesenchymal chondrosarcomas (ESMC). ESMC is a rare malignant tumor arising from soft tissues. The current study presents the case of a 25-year-old male with severe VT arising from RVOT due to metastasis of an ESMC that originally occurred in the retroperitoneum...
September 2016: Experimental and Therapeutic Medicine
Maher Kurdi, Stuart McGregor, Robert Hammond, Fawaz Siddiqi, Bret Wehrli
Clear cell chondrosarcoma is a rare cartilaginous tumor that arises commonly in the epiphyses of the proximal femur or humerus. Spinal involvement is extremely rare, but when present, it most frequently involves the thoracic spine. Clear cell chondrosarcoma is rarely reported in thoracic spine. We report a case of a 70-year-old man with clear cell chondrosarcoma of the T7-8 thoracic spine. Gross en bloc resection of T6-8 vertebral bodies with reconstruction and fusion followed by radiotherapy were performed...
August 30, 2016: International Journal of Surgical Pathology
Caroline Peyrode, Valérie Weber, Aurélien Voissière, Aurélie Maisonial-Besset, Aurélien Vidal, Philippe Auzeloux, Vincent Gaumet, Michèle Borel, Marie-Mélanie Dauplat, Mercedes Quintana, Françoise Degoul, Francoise Redini, Jean-Michel Chezal, Elisabeth Miot-Noirault
To date, surgery remains the only option for the treatment of chondrosarcoma (CHS), which is radio- and chemoresistant due in part to its large extracellular matrix (ECM) and poor vascularity. In case of unresectable locally advanced or metastatic diseases with a poor prognostic, improving the management of CHS still remains a challenge. Our team develops an attractive approach of improvement of the therapeutic index of chemotherapy by targeting proteoglycan(PG)-rich tissues using a quaternary ammonium (QA) function conjugated to melphalan (Mel)...
August 29, 2016: Molecular Cancer Therapeutics
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