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https://www.readbyqxmd.com/read/28917072/primary-extraskeletal-mesenchymal-chondrosarcoma-arising-from-the-iliac-vein
#1
Hua Zhang, Shuai Wang, Zhihua Cheng, Han Liu
The iliac vein is an extremely rare site for mesenchymal chondrosarcoma, and patients with primary extraskeletal mesenchymal chondrosarcoma arising from a vein always suffer a very poor prognosis. We report a case of a 45-year-old female who presented with a 5-month history of left leg edema in 2015. Contrast-enhanced computed tomography showed a large mass in the left iliac vein with scattered calcifications. Wide-margin resection was performed, and histopathologic and immunohistochemical analyses confirmed the presence of intraluminal mesenchymal chondrosarcoma with local invasion out of the vein wall...
October 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28913138/chondrosarcoma-mimicking-an-adnexal-mass-a-very-rare-case-report
#2
Hüseyin Çağlayan Özcan, Aynur Mustafa, Zehra Bozdağ, Seyhun Sucu, Özcan Balat
Chondrosarcoma is considered as a common primary bone sarcoma. These sarcomas can form large masses without any specific symptoms because there are no barriers in pelvic anatomy to prevent the enlargement of tumors, and can mimic ovarian masses. We present a pelvic chondrosarcoma in a woman aged 37 years who was misdiagnosed as having an ovarian mass due to the limited information obtained from imaging studies. Pelvic chondrosarcoma should be considered in patients who have pelvic masses with solid components...
March 2017: Turk J Obstet Gynecol
https://www.readbyqxmd.com/read/28906396/chondrosarcoma-of-the-patella-a-case-report
#3
Conglin Ye, Zhiping Luo, Jin Zeng, Min Dai
RATIONALE: Chondrosarcoma, characterized by the production of cartilage matrix, is a common bone tumor, accounting for 20% to 27% of all malignant bone tumors. It often occurs in the cartilage of the pelvis, femur, tibia, and humerus. However, chondrosarcoma of the patella is extremely rare. PATIENT CONCERNS: The present study describes a case of chondrosarcoma affecting the right patella in a 68-year-old woman. The chief complaints were painful swelling and limitation of motion of the right knee for about half a year...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28906125/imaging-of-rare-appendicular-non-acral-soft-tissue-chondromas-in-adults-with-histopathologic-correlation
#4
Mohamed Ragab Nouh, Hanan Abd El-Aziz Amr, Rola H Ali
Background Soft-tissue chondroma (STC) is a rare benign soft tissue tumor that arises primarily in acral extra-skeletal locations. Occasionally, STCs may arise in more proximal non-acral locations, accompanied by non-classic features that label them as indeterminate lesions and pose diagnostic challenge for both radiologists and pathologists alike. Purpose To explicate the potential of diagnostic imaging in the identification and characterization of appendicular non-acral STCs with emphasis on their morphologic magnetic resonance imaging (MRI) enhancement...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28867901/primary-intracranial-extraskeletal-mesenchymal-chondrosarcoma-clinical-mimicry-as-glomus-jugulare
#5
Rajesh Chhabra, Manjul Tripathi, Devi Prasad Patra, Narendra Kumar, Bishan Radotra, Kanchan Kumar Mukherjee
BACKGROUND: Extraskeletal mesenchymal chondrosarcoma (ESMCS) is an unusual pathologic variant of chondrosarcoma. There are no specific clinicoradiographic parameters to distinguish it from other intracranial pathologies. The diagnosis can be established only on the basis of histopathology, which may pose significant challenges in certain unusual locations. PURPOSE: In this case, we discuss the pitfalls in diagnosis, management, and major characteristics of ESMCS with a review of current literature...
July 2017: Annals of Neurosciences
https://www.readbyqxmd.com/read/28838115/endoscopic-endonasal-approach-to-the-ventral-jugular-foramen-anatomical-basis-technical-considerations-and-clinical-series
#6
Francisco Vaz-Guimaraes, Ana Carolina I Nakassa, Paul A Gardner, Eric W Wang, Carl H Snyderman, Juan C Fernandez-Miranda
BACKGROUND: Surgical exposure of the jugular foramen (JF) is challenging given its complex regional anatomy and proximity to critical neurovascular structures. OBJECTIVE: To describe the anatomical basis, surgical technique, and outcomes of a group of patients who underwent the endoscopic endonasal approach to the JF. METHODS: Five silicon-injected anatomical specimens were prepared for dissection. Additionally, a chart review was conducted through our patient database, searching for endonasal exposure of the JF...
August 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28838112/endoscopic-endonasal-surgery-for-cranial-base-chondrosarcomas
#7
Francisco Vaz-Guimaraes, Juan C Fernandez-Miranda, Maria Koutourousiou, Ronald L Hamilton, Eric W Wang, Carl H Snyderman, Paul A Gardner
BACKGROUND: Microsurgical resection via open approaches is considered the main treatment modality for cranial base chondrosarcomas (CBCs). The use of endoscopic endonasal approaches (EEAs) has been rarely reported. OBJECTIVE: To present the endoscopic endonasal experience with CBCs at our institution. METHODS: Retrospective review of the medical records of 35 consecutive patients who underwent EEA for CBC resection between January 2004 and April 2013...
August 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28832074/programmed-death-ligand-1-pd-l1-expression-in-malignant-mesenchymal-tumors
#8
Kemal Kösemehmetoğlu, Ece Özoğul, Berrin Babaoğlu, Gaye Güler Tezel, Gökhan Gedikoğlu
OBJECTIVE: Programmed death ligand 1 (PD-L1) found on tumor cells has recently been reported to have a key role in the development and dissemination of many tumors, such as lung and breast carcinomas. In this study, we retrospectively analyzed PD-L1 expression among different types of sarcomas. MATERIAL AND METHOD: Tissue microarrays of 3-4 mm diameter were composed from paraffin blocks of 222 various sarcomas. Slides prepared from microarrays were stained for PD-L1 antibody (Cell Signaling, E1L3N®) using Leica Bond Autostainer...
2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28827101/sarcomatoid-carcinoma-associated-with-small-cell-carcinoma-of-the-urinary-bladder-a-series-of-28-cases
#9
Yuly Ramirez Urrea, Jonathan I Epstein
The association of sarcomatoid carcinoma (SC) with small cell carcinoma (SCC) has not been systematically studied. We identified 39 consult cases between 2001-2016 with available slides for review in 28 cases. There were 19 men and 9 women [mean age: 78years (51-89)]. In 26 (92.8%) cases, the sarcomatoid component had nonspecific malignant spindle cells, 4 (14%) chondrosarcoma, 2 (7%) myxoid sarcomatous, 1 (3.5%) osteosarcoma, and 1 (3.5%) rhabdomyosarcoma. The predominant component was in 11 (39%) cases SCC, 6 (21%) urothelial carcinoma, 3 (10%) sarcomatoid, and 8 (29%) equal sarcomatoid and SCC...
August 18, 2017: Human Pathology
https://www.readbyqxmd.com/read/28822621/chondrosarcoma-of-the-epiglottis-a-case-report-and-literature-review
#10
REVIEW
Jonathan Choi, Harish Dharmarajan, Andrew Victores, Ashley Wenaas, Julina Ongkasuwan
BACKGROUND: Laryngeal chondrosarcoma (LCS) is an exceedingly rare malignancy and least frequently reported in the epiglottis. METHODS AND RESULTS: We report a case of a 71-year-old male smoker who presented with sore throat, dysphagia, and odynophagia for 3 months. Computed tomography scan revealed an inhomogeneously enhancing necrotic mass emanating from the right epiglottis and traveling along the aryepiglottic fold. The mass was removed via endoscopic en bloc laser resection...
August 16, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28812954/mesenchymal-chondrosarcoma-of-the-orbit-a-case-report-with-5%C3%A2-years-of-follow-up
#11
Md Shahid Alam, Nirmala Subramanian, Akruti Sunil Desai, S Krishnakumar
Mesenchymal chondrosarcoma is a rare orbital tumor. Several case reports of this rare tumor have been published in the literature but only 6 cases have documented a follow up of 5 years or more. We report a case of 28 year-old female who presented with left orbital mass. Computed Tomography (CT) revealed a lobulated mass in the superior extraconal space with dense intralesional calcification. Patient underwent complete resection of the mass and histopathology was suggestive of mesenchymal chondrosarcoma. He was given adjuvant radiotherapy and there was no recurrence or metastasis at 5 years of follow-up...
August 16, 2017: Orbit
https://www.readbyqxmd.com/read/28802390/pediatric-head-and-neck-bone-sarcomas-an-analysis-of-204-cases
#12
Jacob S Brady, Sei Y Chung, Emily Marchiano, Jean Anderson Eloy, Soly Baredes, Richard Chan Woo Park
OBJECTIVES: To analyze the demographics, survival, and treatment efficacy of pediatric sarcomas of the facial skeleton and skull. METHODS: Retrospective study of cases from the US National Cancer Institute's Surveillance, Epidemiology, and End Results database. Pediatric patients between the ages of 0 and 18 diagnosed with a malignant sarcoma of either the mandible or the bones of skull, face, and associated joints from 1973 to 2013 were studied. RESULTS: In total, 204 patients were included in the analysis...
September 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28797501/integrating-morphology-and-genetics-in-the-diagnosis-of-cartilage-tumors
#13
REVIEW
Carlos E de Andrea, Mikel San-Julian, Judith V M G Bovée
Cartilage-forming tumors of bone are a heterogeneous group of tumors with different molecular mechanisms involved. Enchondromas are benign hyaline cartilage-forming tumors of medullary bone caused by mutations in IDH1 or IDH2. Osteochondromas are benign cartilage-capped bony projections at the surface of bone. IDH mutations are also found in dedifferentiated and periosteal chondrosarcoma. A recurrent HEY1-NCOA2 fusion characterizes mesenchymal chondrosarcoma. Molecular changes are increasingly used to improve diagnostic accuracy in chondrosarcomas...
September 2017: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/28764925/profile-of-european-proton-and-carbon-ion-therapy-centers-assessed-by-the-eortc-facility-questionnaire
#14
Damien C Weber, André Abrunhosa-Branquinho, Alessandra Bolsi, Andrzej Kacperek, Rémi Dendale, Dirk Geismar, Barbara Bachtiary, Annika Hall, Jens Heufelder, Klaus Herfarth, Jürgen Debus, Maurizio Amichetti, Mechthild Krause, Roberto Orecchia, Vladimir Vondracek, Juliette Thariat, Tomasz Kajdrowicz, Kristina Nilsson, Cai Grau
BACKGROUND: We performed a survey using the modified EORTC Facility questionnaire (pFQ) to evaluate the human, technical and organizational resources of particle centers in Europe. MATERIAL AND METHODS: The modified pFQ consisted of 235 questions distributed in 11 sections accessible on line on an EORTC server. Fifteen centers from 8 countries completed the pFQ between May 2015 and December 2015. RESULTS: The average number of patients treated per year and per particle center was 221 (range, 40-557)...
July 29, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28761542/recurrent-intraventricular-meningioma-with-malignant-transformation
#15
Jasmit Singh, Hrushikesh Kharosekar, Vernon Velho
Benign meningioma undergoing a malignant transformation (to a chondrosarcoma) in intraventricular location is very rare and this is first case report to best of our knowledge. Herein, we report a rare case of malignant transformation of a benign intraventricular meningioma with relevant literature.
July 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28761532/skull-base-bony-lesions-management-nuances-a-retrospective-analysis-from-a-tertiary-care-centre
#16
Amit Kumar Singh, Arun Kumar Srivastava, Jayesh Sardhara, Kamlesh Singh Bhaisora, Kuntal Kanti Das, Anant Mehrotra, Rabi Narayan Sahu, Awadhesh Kumar Jaiswal, Sanjay Behari
BACKGROUND: Skull base lesions are not uncommon, but their management has been challenging for surgeons. There is large no of bony tumors at the skull base which has not been studied in detail as a group. These tumors are difficult not only because of their location but also due to their variability in the involvement of important local structure. Through this retrospective analysis from a Tertiary Care Centre, we are summarizing the details of skull base bony lesions and its management nuances...
July 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28756568/low-grade-chondrosarcoma-of-the-cricoid-cartilage-a-case-report-and-review-of-the-literature
#17
Chuan-Ping Gao, Ji-Hua Liu, Feng Hou, Hua Liu, Wen-Jian Xu
We report the case of a 60-year-old man with a 12-day history of vomiting whenever he had a meal. Computed tomography revealed a calcified mass in the right cricoid cartilage with intraluminal and extraluminal extension. The patient underwent surgical resection of the trachea with end-to-end anastomosis. Pathological examination of the surgical specimen showed a low-grade chondrosarcoma. Eighteen months after surgery, the patient is alive and disease-free.
July 29, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28733066/effective-use-of-levosimendan-in-anthracycline-induced-cardiomyopathy-a-case-report
#18
Nikolaos Miaris, Stefanos Zezas, Joseph Sgouros, Dimitra-Christina Zirou, Stefania Gkoura, George Stamoulis, Helen Angelopoulou, George Avgeropoulos, Epaminondas Samantas
BACKGROUND: Anthracycline-induced cardiomyopathy is a serious side effect that ranges from mild left ventricular systolic impairment to congestive heart failure and cardiogenic shock. Currently, there is no evidence indicating the effective use of levosimendan in these cases. OBJECTIVE: We aim to present a case of life-threatening doxorubicin-induced cardiomyopathy that was successfully managed with levosimendan. CASE: A 48-year-old female with formerly normal heart function, who had been treated with doxorubicin-based regimens for dedifferentiated chondrosarcoma, presented with cardiomyopathy with low left ventricular ejection fraction eight months after the last infusion...
July 18, 2017: Heart & Lung: the Journal of Critical Care
https://www.readbyqxmd.com/read/28717079/severe-hypocalcemia-in-a-patient-with-recurrent-chondrosarcoma
#19
Jung Nam Eun, Yoo Duk Choi, Jeong Ho Lee, Yun Ah Jeong, Jee Hee Yoon, Hee Kyung Kim, Ho-Cheol Kang
Hypocalcemia is relatively uncommon paraneoplastic syndrome. Only one case of hypocalcemia has been reported in a patient with chondrosarcoma. We herein report a case of a 32-year-old woman with metastatic chondrosarcoma with tetany. Her imaging findings revealed multiple calcific metastatic lesions in the lungs, pancreas, left atrium, and pulmonary vein. A laboratory examination showed hypocalcemia with no evidence of any other disease that could induce hypocalcemia. On the basis of the laboratory and clinical findings, we concluded the etiology of her severe hypocalcemia to be excessive calcium consumption by the tumor itself...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28706394/proximal-epithelioid-sarcomatous-dedifferentiation-in-secondary-chondrosarcoma-in-a-known-case-of-multiple-osteochondromatosis
#20
Biswajit Dey, Mangesh Chikhale, Prita Pradhan, Adarsh Barwad, Bhawana Ashok Badhe
Osteochondroma is the most common benign bone tumor. Approximately 15% of osteochondromas occur as multiple lesions. Multiple osteochondromatosis has a higher risk of developing chondrosarcomas, which are of low grade with good prognosis. About 10% of all chondrosarcomas may undergo dedifferentiated change, which has a poorer prognosis. Dedifferentiated peripheral chondrosarcoma developing within an osteochondroma is extremely rare. Dedifferentiation usually occurs in the form of osteosarcoma, malignant fibrous histiocytoma, fibrosarcoma, or rhabdomyosarcoma...
July 2017: Journal of Laboratory Physicians
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