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Yiyi Sun, Zhihe Zang, Ling Zhong, Min Wu, Qing Su, Xiurong Gao, Wang Zan, Dong Lin, Yan Zhao, Zhonglin Zhang
Adiponectin, the adipose-derived hormone, plays an important role in the suppression of metabolic disorders that can result in type 2 diabetes, obesity, and atherosclerosis. It has been shown that up-regulation of adiponectin or adiponectin receptor has a number of therapeutic benefits. Given that it is hard to convert the full size adiponectin protein into a viable drug, adiponectin receptor agonists could be designed or identified using high-throughput screening. Here, we report on the development of a two-step screening process to identify adiponectin agonists...
2013: PloS One
Valeria Calcaterra, Mara De Amici, Catherine Klersy, Cristina Torre, Vincenza Brizzi, Francesca Scaglia, Michela Albanesi, Riccardo Albertini, Benedetta Allais, Daniela Larizza
The metabolic syndrome (MetS) is a common basis for the development of atherogenic cardiovascular disease. Adiponectin has been demonstrated to be insulin-sensitizing and an anti-atherogenic factor and is considered a key ofMetS. It was suggested that IL-10 may be involved in the inflammatory network of MetS in relation to adiponectin. We examined the relationship between adiponectin, IL-10 and MetS in pediatric obese patients. MetS components were assessed in 70 severely obese and 30 non-obese children and adolescents...
August 2009: Acta Bio-medica: Atenei Parmensis
Guang-De Zhou, Mei-Rong Li, Jing Zhang, Deng Pan, Su-Xian Zhao, Jian-Fa Yang, Jun Yu, Jing-Min Zhao
OBJECTIVE: Currently, no agent has been conclusively demonstrated to prevent the progression of non-alcoholic steatohepatitis (NASH). Chitosan, a natural product derived from chitin, was thought to possess hypocholesterolemic properties. The aim of this study was to evaluate the potential effects of chitosan on nutritional steatohepatitis in rats. MATERIAL AND METHODS: Rats were fed with a high fat diet for 4 weeks to develop NASH that was confirmed by liver biopsy, and then 4 weeks of chitosan was given...
2008: Scandinavian Journal of Gastroenterology
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