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Hypogonadism

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https://www.readbyqxmd.com/read/28812471/effectiveness-and-tolerability-of-parenteral-testosterone-undecanoate-a-post-marketing-surveillance-study
#1
Jan Wolf, Dieter Keipert, Heiko Motazedi, Michael Ernst, Joanne Nettleship, Louis Gooren
This observational post-marketing study of parenteral testosterone undecanoate (TU) in a non-selected population aimed to: examine the effectiveness of TU as treatment of hypogonadism; record adverse drug reactions (ADR) quantitatively particularly regarding polycythemia, prostate safety and cardiovascular-related metabolic risk factors; and verify whether recommended injection intervals apply to routine clinical practice. Eight hundred and seventy subjects from 259 outpatient units scheduled to visit the clinic six times were included...
August 16, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/28807822/does-long-term-androgen-deficiency-lead-to-metabolic-syndrome-in-middle-aged-rats
#2
Veronika Borbélyová, Emese Domonkos, Janka Bábíčková, Ľubomíra Tóthová, Mária Kačmárová, Oľga Uličná, Daniela Ostatníková, Július Hodosy, Peter Celec
Evidence from clinical observational studies and animal experiments suggests that hypogonadism is associated with the metabolic syndrome. In most of the experiments, androgen deficiency is induced by gonadectomy in the adulthood and relatively short-term effects of hypogonadism on metabolic parameters are usually observed. The purpose of this study was to evaluate the metabolic effects of long-term androgen deficiency starting before puberty in middle-aged male rats. The components of the metabolic syndrome were examined in male, female and gonadectomized male rats at the age of 18months...
August 11, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28807505/delayed-ejaculation-and-associated-complaints-relationship-to-ejaculation-times-and-serum-testosterone-levels
#3
Abraham Morgentaler, Paula Polzer, Stanley Althof, Alexander Bolyakov, Craig Donatucci, Xiao Ni, Ankur B Patel, Shehzad Basaria
BACKGROUND: Although delayed ejaculation (DE) is typically characterized as a persistently longer than anticipated or desired time to ejaculation (or orgasm) during sexual activity, a timing-based definition of DE and its association with serum testosterone has not been established in a large cohort. AIM: To examine in an observational study estimated intravaginal ejaculatory latency time (IELT) and masturbatory ejaculation latency time (MELT) in men self-reporting DE, assess the association of IELT and MELT with serum testosterone levels, and determine whether correlation with demographic and sexual parameters exist...
August 11, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28807454/reconsidering-olfactory-bulb-magnetic-resonance-patterns-in-kallmann-syndrome
#4
Thomas Hacquart, Aïcha Ltaief-Boudrigua, Cécile Jeannerod, Salem Hannoun, Gérald Raverot, Michel Pugeat, Aude Brac de la Perriere, Véronique Lapras, Frédérique Nugues, Catherine Dode, Francois Cotton
OBJECTIVE: The aim of this retrospective study was to perform magnetic resonance imaging assessment of olfactory pathway and skull base abnormalities in Kallmann syndrome (KS) patients with hypogonadotropic hypogonadism and olfaction disorder. METHODS: Magnetic resonance brain patterns were retrospectively studied in 19 patients clinically classified as KS. Qualitative assessment of olfactory bulb region comprised bulb atrophy and rectus and medial orbital gyrus ptosis; quantitative assessment measured olfactory fossa depth and width, sulcus depth and ethmoid angle...
August 11, 2017: Annales D'endocrinologie
https://www.readbyqxmd.com/read/28802362/kallmann-syndrome-in-pediatric-otorhinolaryngology-practice-case-report-and-literature-review
#5
Karolina Dżaman, Karolina Zborowska-Piskadło, Mirosława Pietniczka-Załęska, Ireneusz Kantor
BACKGROUND: Kallmann syndrome (KS) is an isolated form of hypogonadotrophic hypogonadism (HH) in combination with a defect in olfactory function. The diagnosis of KS before maturation is often difficult to make due to the broad spectrum of presentation and genetic heterogeneities. ENT examination including smell test is essential for proper diagnosis of olfactory disturbances and non olfactory abnormalities in craniofacial region which may also be existent in KS. CASE: A 17-year-old girl admitted to ENT Department because of the olfactory sense disturbances since two years...
September 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28802064/neurokinin-3-receptor-antagonism-decreases-gonadotropin-and-testosterone-secretion-in-healthy-men
#6
Karolina Skorupskaite, Jyothis T George, Johannes D Veldhuis, Robert P Millar, Richard A Anderson
OBJECTIVE: Patients with mutations of NKB and its receptor show hypogonadotrophic hypogonadism, but there is little evidence for the importance of this pathway in reproductive function in normal men, or its functional hierarchy with kisspeptin. DESIGN: An open label study wherein men (n=6) were administered the NK3R antagonist MLE4901 40mg orally twice a day for 7 days. Kisspeptin-10 (0.3 μg/kg iv bolus) was given before and on day 7 of NK3R antagonist treatment...
August 12, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28797374/hormone-replacement-the-fountain-of-youth
#7
REVIEW
Bradley R Williams, Janet Soojeung Cho
Natural aging brings reduced production of growth and sex hormones, beginning in middle age, with noticeable physiologic changes by the sixth or seventh decade of life: reduced muscle mass, energy, and exercise capacity and alterations in sexual function. Hormones and hormone precursors have been investigated to delay changes in body composition, strength, and physical and cognitive function. Menopausal hormone therapy is effective for vasomotor and genitourinary symptoms. Testosterone is effective in men with hypogonadism and declines in physiologic function...
September 2017: Primary Care
https://www.readbyqxmd.com/read/28795962/testosterone-therapy-improves-well-being-and-psychological-health
#8
Jason Akerman, Jason R Kovac, Larry I Lipshultz
PURPOSE OF REVIEW: To ascertain whether testosterone therapy (TTh) improves psychological health and a sense of overall well being in a number of clinical domains. RECENT FINDINGS: Recent work suggests small but durable and replicable improvements in the components of male health and well being. SUMMARY: Symptomatic hypogonadism is frequently associated with decreased libido and fatigue that contributes to lowered overall quality-of-life and worsening psychological health...
August 8, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28794910/first-report-of-two-rare-entities-in-a-family-49-xxxxy-and-45-x
#9
Yavuz Şahin, Aysegül Özcan
49,XXXXY and 45,X syndromes are sex chromosome aneuploidies in which the affected individuals present with hypergonadotropic hypogonadism, short or long stature, and skeletal malformations. Psychological, endocrinological, and orthopaedic disorders constitute the major problems in the clinical follow-up. We report a family with two rare entities: 49,XXXXY and 45, X. Sex chromosome abnormalities should especially be in mind in the evaluation of patients with micropenis, mental retardation, and hypergonadotropic hypogonadism...
September 2017: Journal of Pediatric Genetics
https://www.readbyqxmd.com/read/28791186/a-case-of-male-osteoporosis-a-37-year-old-man-with-multiple-vertebral-compression-fractures
#10
Suhaib Radi, Andrew C Karaplis
While the contributing role of testosterone to bone health is rather modest compared to other factors such as estradiol levels, male hypogonadism is associated with low bone mass and fragility fractures. Along with stimulating physical puberty by achieving virilization and a normal muscle mass and improving psychosocial wellbeing, the goals of testosterone replacement therapy in male hypogonadism also include attainment of age-specific bone mineral density. We report on a 37-year-old man who presented with multiple vertebral compression fractures several years following termination of testosterone replacement therapy for presumed constitutional delay in growth and puberty...
2017: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/28782738/trials-of-testosterone-replacement-reporting-cardiovascular-adverse-events
#11
Thiago Gagliano-Jucá, Shehzad Basaria
The numbers of testosterone prescriptions written have increased several-fold worldwide, but the incidence of pathological hypogonadism due to hypothalamic, pituitary, and testicular disease has remained unchanged. Most of these prescriptions are being dispensed to middle-aged and older men who have experienced age-related decline in serum testosterone levels; a subset of the population in which benefits of testosterone replacement is at best, modest. Recently, some randomized controlled trials have reported increased cardiovascular events in men (mainly older men and those with prevalent cardiovascular disease) with testosterone use, and a few recent meta-analyses have confirmed these findings...
August 4, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28782309/study-of-seminal-fluid-parameters-and-fertility-of-male-sickle-cell-disease-patients-and-potential-impact-of-hydroxyurea-treatment
#12
Lulup Kumar Sahoo, Bipin Kishore Kullu, Siris Patel, Nayan Kumar Patel, Pragyan Rout, Prasanta Purohit, Satyabrata Meher
INTRODUCTION: Male Sickle cell disease (SCD) patients often have moderate to severe hypogonadism resulting in abnormal seminal fluid parameters due to testicular dysfunction. Hydroxyurea (HU), the only drug found to be effective in preventing morbidity and mortality in sickle cell disease patients has been found to further aggravate the testicular dysfunction. MATERIAL AND METHODS: This was a prospective study done at a tertiary care hospital over 26 months between September 2011 to October 2013...
June 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28781213/quality-of-life-and-sexual-function-benefits-of-long-term-testosterone-treatment-longitudinal-results-from-the-registry-of-hypogonadism-in-men-rhyme
#13
Raymond C Rosen, Frederick Wu, Hermann M Behre, Hartmut Porst, Eric J H Meuleman, Mario Maggi, Javier Romero-Otero, Juan I Martinez-Salamanca, Thomas Hugh Jones, Frans M J Debruyne, Karl-Heinz Kurth, Geoff I Hackett, Richard Quinton, Peter Stroberg, Yacov Reisman, Edoardo S Pescatori, Antonio Morales, Lluis Bassas, Natalio Cruz, Glenn R Cunningham, Olivia A Wheaton
BACKGROUND: The benefits and risks of long-term testosterone administration have been a topic of much scientific and regulatory interest in recent years. AIM: To assess long-term quality of life (QOL) and sexual function benefits of testosterone replacement therapy (TRT) prospectively in a diverse, multinational cohort of men with hypogonadism. METHODS: A multinational patient registry was used to assess long-term changes associated with TRT in middle-age and older men with hypogonadism...
August 3, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28780520/bone-microarchitecture-and-estimated-bone-strength-in-men-with-active-acromegaly
#14
Paula Pb Silva, Fatemeh Ghazanfari Amlashi, Elaine W Yu, Karen J Pulaski-Liebert, Anu Gerweck, Pouneh Fazeli, Elizabeth A Lawson, Lisa B Nachtigall, Beverly M K Biller, Karen K Miller, Anne Klibanski, M Bouxsein, Nicholas A Tritos
CONTEXT: Both acromegaly and adult growth hormone deficiency (GHD) are associated with increased fracture risk. Sufficient data are lacking regarding cortical bone microarchitecture and bone strength, as assessed by micro-finite element analysis (µFEA). OBJECTIVE: To elucidate both cortical and trabecular bone microarchitecture and estimated bone strength in men with active acromegaly or GHD compared to healthy controls. DESIGN AND SUBJECTS: Cross-sectional study at a clinical research center, including 48 men (16 with acromegaly, 16 with GHD and 16 healthy controls)...
August 5, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28777369/-obstructive-sleep-apnea-syndrome-and-age-related-hypohonadism
#15
I M Madaeva, O N Berdina, N V Semenova, V V Madaev, L V Rychkova, L I Kolesnikova
BACKGROUND: Obstructive sleep apnea syndrome (OSAS) is a common disease that causes a different spectrum of life processes violations in the continuum of 'sleep-wakefulness'. OSAS in combination with age-specific hypogonadism as a systemic pathology requires certain interdisciplinary approaches involving both the correction of the obstruction, and testosterone therapy in men with hypogonadism. AIM: Assessment of the effect of combined use of CPAP (Continuous Positive Airway Pressure) and testosterone replacement therapy (transdermal form - Androgel) on indicators of polysomnography monitoring (PSG) with simultaneous study of erectile function and testosterone secretion...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28774772/cardiovascular-health-erectile-dysfunction-and-testosterone-replacement-controversies-and-correlations
#16
REVIEW
Fuad F Elkhoury, Amarnath Rambhatla, Jesse N Mills, Jacob Rajfer
Erectile dysfunction (ED) and cardiovascular disease (CVD) share a similar underlying pathophysiology, and low serum testosterone, known as hypogonadism, is a significant player in both conditions. Hypogonadism is a known risk factor for cardiovascular events and worsened mortality, thus influencing physicians to recommend testosterone replacement in such patients. However, at least four recent reports suggest that testosterone replacement may worsen cardiovascular risk, heightening hesitancy in the medical community to treat hypogonadal men with testosterone...
July 31, 2017: Urology
https://www.readbyqxmd.com/read/28771964/testosterone-replacement-therapy-improved-sexual-desire-and-erectile-function-in-men-with-type-2-diabetes-following-a-30-week-randomized-placebo-controlled-study
#17
G Hackett, N Cole, A Saghir, P Jones, R C Strange, S Ramachandran
Although testosterone replacement treatment (TRT) can improve sexual function in many hypogonadal (HG) men with type 2 diabetes (T2DM), some show either no improvement or only in a limited number of domains. Indeed, it is often difficult for the clinician to offer an indication of the likely efficacy of TRT as little data exist on the proportion of TRT-treated men who will demonstrate improvement in domains such as sexual desire (SxD) and erectile function (EF). We describe in men with T2DM: firstly, the likelihood of improved sexual desire (SxD) and erectile function (EF) following TRT at various time points, and secondly, if probability of SxD change predicted likelihood of subsequent EF change...
August 3, 2017: Andrology
https://www.readbyqxmd.com/read/28770686/body-composition-changes-with-testosterone-replacement-therapy-following-spinal-cord-injury-and-aging-a-mini-review
#18
Tom E Nightingale, Pamela Moore, Joshua Harman, Refka Khalil, Ranjodh S Gill, Teodoro Castillo, Robert A Adler, Ashraf S Gorgey
Context Hypogonadism is a male clinical condition in which the body does not produce enough testosterone. Testosterone plays a key role in maintaining body composition, bone mineral density, sexual function, mood, erythropoiesis, cognition and quality of life. Hypogonadism can occur due to several underlying pathologies during aging and in men with physical disabilities, such as spinal cord injury (SCI). This condition is often under diagnosed and as a result, symptoms undertreated. Methods In this mini-review, we propose that testosterone replacement therapy (TRT) may be a viable strategy to improve lean body mass (LBM) and fat mass (FM) in men with SCI...
August 3, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28760247/psychometric-evaluation-of-the-hypogonadism-impact-of-symptoms-questionnaire-short-form-his-q-sf
#19
Heather L Gelhorn, Laurie J Roberts, Nikhil Khandelwal, Dennis A Revicki, Leonard R DeRogatis, Adrian Dobs, Zsolt Hepp, Michael G Miller
BACKGROUND: The Hypogonadism Impact of Symptoms Questionnaire Short Form (HIS-Q-SF) is a patient-reported outcome measurement designed to evaluate the symptoms of hypogonadism. The HIS-Q-SF is an abbreviated version including17 items from the original 28-item HIS-Q. AIM: To conduct item analyses and reduction, evaluate the psychometric properties of the HIS-Q-SF, and provide guidance on score interpretation. METHODS: A 12-week observational longitudinal study of hypogonadal men was conducted as part of the original HIS-Q psychometric evaluation...
August 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28759938/irisin-and-testosterone-in-men-with-metabolic-syndrome
#20
Zdravko Kamenov, Yavor Assyov, Petya Angelova, Antoaneta Gateva, Adelina Tsakova
The beneficial effects of testosterone on the metabolism and body composition of men are well established but the exact mechanisms of these effects are not clearly understood. A potential explanation might lie in the hormones, secreted from skeletal muscles, named "myokines". One such myokine, irisin, has been shown to also have potential beneficial metabolic effects. The aim of this pilot study was to evaluate the association of serum testosterone with circulating serum irisin levels in men with metabolic syndrome...
July 31, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
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