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temozolamide

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https://www.readbyqxmd.com/read/27742374/angiocentric-glioma-transformed-into-anaplastic-ependymoma-review-of-the-evidence-for-malignant-potential
#1
James A McCracken, Michael F Gonzales, Pramit M Phal, Katharine J Drummond
Angiocentric glioma (AG) is a low grade glioma, that was first described in 2002. Since this description, 83 patients with AG have been described, including ours. AG typically presents in childhood with medically refractory seizures that are cured with gross surgical resection. Whilst the natural history is that of a benign tumour, there have been reports of recurrence, transformation, and malignant features that suggest that AG is potentially malignant. We add to the literature a case of a 16-year-old girl who presented in May 2011 with a 3-month history of complex partial seizures, with MRI showing a T2-weighted hyperintense lesion in the left insula and inferior frontal lobe...
October 11, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27675511/hypofractionated-radiation-therapy-with-concurrent-temozolamide-for-recurrent-high-grade-glioma
#2
S Garg, J D Palmer, H Kim, N L Williams, D Bhamidipati, J Skowronski, J Glass, M Werner-Wasik, L Kim, W Shi
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27438798/association-between-perioperative-hyperglycemia-and-survival-in-patients-with-glioblastoma
#3
Katherine Hagan, Shreyas Bhavsar, Radha Arunkumar, Roxana Grasu, Anh Dang, Richard Carlson, Charles Cowles, Benjamin Arnold, Yuri Potylchansky, Thomas F Rahlfs, Ian Lipski, Caroline Walsh, Federico Jimenez, Anh T Nguyen, Lei Feng, Juan P Cata
BACKGROUND: Several studies have examined the association between hyperglycemia in the first 10 to 12 weeks following surgery and postoperative survival in glioblastoma multiforme (GBM) patients. We hypothesize that episodes of hyperglycemia before, during and/or following surgery for primary GBM are independent predictors of disease progression and mortality. MATERIALS AND METHODS: A total of 162 adult patients were included in the analysis. All patients received adjuvant temozolamide...
July 19, 2016: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/27105898/severe-periocular-bleeding-induced-by-bevacizumab-in-a-patient-with-recurrent-glioblastoma-multiforme
#4
Melek K Eryılmaz, Hasan Mutlu, Fatma Yalçin Müsri, Derya K Salim, Gökhan Tazegül, Hasan Ş Coşkun
Bevacizumab is a humanized monoclonal antibody targeting vascular endothelial growth factor, and it has been shown to improve progression-free survival in patients with recurrent glioblastome multiforme when administered as second-line therapy. However, it has been associated with serious and fatal hemorrhagic events. Here, we present a 68-year-old male who developed severe periocular bleeding while on bevacizumab for recurrent temozolamide-resistant glioblastome multiforme.
April 22, 2016: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/27105440/observation-on-enhanced-avidity-on-somatostatin-receptor-targeted-68ga-dotatate-pet-ct-following-therapy-with-everolimus-and-capecitabine-temozolamide-is-redifferentiation-akin-phenomenon-a-reality-in-neuroendocrine-tumors
#5
https://www.readbyqxmd.com/read/27076281/assessment-of-early-response-to-tumor-treating-fields-in-newly-diagnosed-glioblastoma-using-physiologic-and-metabolic-mri-initial-experience
#6
Suyash Mohan, Sanjeev Chawla, Sumei Wang, Gaurav Verma, Aaron Skolnik, Steven Brem, Katherine B Peters, Harish Poptani
Tumor-treating fields (TTFields) is a novel antimitotic treatment modality for patients with glioblastoma. To assess response to TTFields, a newly diagnosed patient with glioblastoma underwent diffusion, perfusion and 3D echo-planar spectroscopic imaging prior to initiation of TTFields plus temozolamide (baseline) and at 1- and 2-month follow-up periods. Increased mean diffusivity along with decreased fractional anisotropy and maximum relative cerebral blood volume were noted at 2 months relative to baseline suggesting inhibition of tumor growth and angiogenesis...
July 2016: CNS Oncology
https://www.readbyqxmd.com/read/27034802/use-of-molecular-studies-for-treatment-of-metastatic-pleomorphic-large-cell-pancreatic-cancers-a-novel-strategy
#7
Parikshit Padhi, Arshjyot Narula, Anna Balog, Antonios Christou
Pleomorphic large cell pancreatic cancer is a rare and more aggressive variant with no proven treatment in the metastatic setting. It constitutes about 1% of the total pancreatic cancer cases. In the absence of any standard of care, we aim to increase awareness amongst clinical practitioners that molecular level testing, using immunohistochemistry, next-generation sequencing and chromogenic in-situ hybridization can help in making chemotherapeutic decisions for this variant of pancreatic cancer. We present a 50-year-old male who presented to our hospital complaining of persistent abdominal pain...
April 2016: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/26921335/p28-mediated-activation-of-p53-in-g2-m-phase-of-the-cell-cycle-enhances-the-efficacy-of-dna-damaging-and-antimitotic-chemotherapy
#8
Tohru Yamada, Tapas K Das Gupta, Craig W Beattie
p28 is an anionic cell-penetrating peptide of 28 amino acids that activates wild-type and mutated p53, leading subsequently to selective inhibition of CDK2 and cyclin A expression and G2-M cell-cycle arrest. In this study, we investigated the cytotoxic effects of p28 treatment alone and in combination with DNA-damaging and antimitotic agents on human cancer cells. p28 enhanced the cytotoxic activity of lower concentrations (IC20-50) of DNA-damaging drugs (doxorubicin, dacarbazine, temozolamide) or antimitotic drugs (paclitaxel and docetaxel) in a variety of cancer cells expressing wild-type or mutated p53...
April 15, 2016: Cancer Research
https://www.readbyqxmd.com/read/26860681/residual-low-adc-and-high-fa-at-the-resection-margin-correlate-with-poor-chemoradiation-response-and-overall-survival-in-high-grade-glioma-patients
#9
Jinrong Qu, Lei Qin, Suchun Cheng, Katherine Leung, Xiang Li, Hailiang Li, Jianping Dai, Tao Jiang, Ayca Akgoz, Ravi Seethamraju, Qifeng Wang, Rifaquat Rahman, Shaowu Li, Lin Ai, Tianzi Jiang, Geoffrey S Young
PURPOSE: We hypothesized that ADC and FA of enhancing tumor (ET) and/or non-enhancing tumor (NT) adjacent to the operative resection margin before and during temozolomide and/or chemoradiation may allow prediction of chemoradiation response and patient survival. MATERIAL AND METHODS: DTI was acquired in 37 patients with newly diagnosed HGG at two time points: after resection at the time of pre-RT planning MRI (Baseline) and after 30Gy of radiation therapy (mid-RT)...
March 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/26673818/a-versatile-ex-vivo-technique-for-assaying-tumor-angiogenesis-and-microglia-in-the-brain
#10
Ali Ghoochani, Eduard Yakubov, Tina Sehm, Zheng Fan, Stefan Hock, Michael Buchfelder, Ilker Y Eyüpoglu, Nicolai E Savaskan
Primary brain tumors are hallmarked for their destructive activity on the microenvironment and vasculature. However, solely few experimental techniques exist to access the tumor microenvironment under anatomical intact conditions with remaining cellular and extracellular composition. Here, we detail an ex vivo vascular glioma impact method (VOGIM) to investigate the influence of gliomas and chemotherapeutics on the tumor microenvironment and angiogenesis under conditions that closely resemble the in vivo situation...
January 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/26616525/metastatic-melanoma-treatment-combining-old-and-new-therapies
#11
REVIEW
Ryan J Davey, Andre van der Westhuizen, Nikola A Bowden
Metastatic melanoma is an aggressive form of cancer characterised by poor prognosis and a complex etiology. Until 2010, the treatment options for metastatic melanoma were very limited. Largely ineffective dacarbazine, temozolamide or fotemustine were the only agents in use for 35 years. In recent years, the development of molecularly targeted inhibitors in parallel with the development of checkpoint inhibition immunotherapies has rapidly improved the outcomes for metastatic melanoma patients. Despite these new therapies showing initial promise; resistance and poor duration of response have limited their effectiveness as monotherapies...
February 2016: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/26603164/stereotactic-radiosurgery-srs-in-high-grade-glioma-judicious-selection-of-small-target-volumes-improves-results
#12
Felix Bokstein, Deborah T Blumenthal, Benjamin W Corn, Eliahu Gez, Diana Matceyevsky, Natan Shtraus, Zvi Ram, Andrew A Kanner
We present a retrospective review of 55 Stereotactic Radiosurgery (SRS) procedures performed in 47 consecutive patients with high-grade glioma (HGG). Thirty-three (70.2%) patients were diagnosed with glioblastoma and 14 (29.8%) with grade III glioma. The indications for SRS were small (up to 30 mm in diameter) locally progressing lesions in 32/47 (68%) or new distant lesions in 15/47 (32%) patients. The median target volume was 2.2 cc (0.2-9.5 cc) and the median prescription dose was 18 Gy (14-24 Gy). Three patients (5...
February 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/26452894/electrochemical-monitoring-of-the-interaction-between-temozolamide-and-nucleic-acids-by-using-disposable-pencil-graphite-electrodes
#13
Cansu Altay, Ece Eksin, Gulsah Congur, Arzum Erdem
Temozolomide (TMZ) is an anticancer drug used for the treatment of adult brain tumour and skin cancer. The biomolecular interaction between TMZ and DNA was investigated for the first time in this study using disposable pencil graphite electrodes (PGEs) in combination with electrochemical techniques. The surface confined interactions between TMZ and different type of nucleic acids were performed. Before/after surface confined interaction process, the oxidation signals of TMZ, guanine and adenine were measured using differential pulse voltammetry (DPV) and PGE and accordingly, the changes at the oxidation signals were evaluated...
November 1, 2015: Talanta
https://www.readbyqxmd.com/read/26272584/anaplastic-astrocytoma-mimicking-herpes-simplex-encephalitis-in-13-year-old-girl
#14
Saurabh Talathi, Neha Gupta, Naresh Reddivalla, Sergey Prokhorov, Menachem Gold
Astrocytoma is the most common childhood brain tumor. Anaplastic astrocytoma (AA) are high grade gliomas (HGG), found very rarely in pediatric patients. AA mainly results from a dedifferentiation of a low grade astrocytoma. Clinical features of supra-tentorial tumors vary according to their anatomic location, biologic aggressiveness and age of the patient. They can be either completely asymptomatic or present with signs of raised intracranial pressure, seizures (about 40% of cases), behavior changes, speech disorders, declining school performance, or hemiparesis...
November 2015: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/26038275/impact-of-oligodendroglial-component-in-glioblastoma-gbm-o-is-the-outcome-favourable-than-glioblastoma
#15
COMPARATIVE STUDY
Jayant S Goda, Shirley Lewis, Aditi Agarwal, Sridhar Epari, Shraddha Churi, A Padmavati, Tejpal Gupta, Prakash Shetty, Aliasgar Moiyadi, Rakesh Jalali
BACKGROUND: Prognosis of patients with glioblastoma with oligodendroglial component (GBM-O) is not well defined. We report our experience of patients of GBM-O treated at our center. METHODS: Between January 2007 and August 2013, out of 817 consecutive patients with glioblastoma (GBM), 74 patients with GBM-O were identified in our prospectively maintained database. An experienced neuropathologist revaluated the histopathology of all these 74 patients and the diagnosis of GBM-O was eventually confirmed in 57 patients...
August 2015: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/26023622/an-early-and-rare-second-malignancy-in-a-treated-glioblastoma-multiforme-is-it-radiation-or-temozolomide
#16
Shina Goyal, Rabi Raja Singh, Sasidharan Balukrishna, Mandeep Bindra, Selvamani Backianathan
Glioblastoma Multiforme (GBM) is a high-grade brain tumour with the most dismal prognosis. There are very few reports on second malignancies occurring in GBM patients, as the survival has been short. Second malignancies have been reported after treatment of malignancies with radiation therapy and chemotherapy especially after 5 to 10 y of treatment. Here in, we present a very unique case where a patient succumbed to sinonasal carcinoma occurring one and half years after treatment of GBM. A 17-year-old boy was diagnosed to have GBM and underwent surgery followed by chemoradiation and adjuvant chemotherapy with Temozolamide...
April 2015: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/25824731/advances-in-the-management-of-unresectable-or-metastatic-pancreatic-neuroendocrine-tumors-chemotherapy-targeted-therapy-hormonal-treatment-and-future-directions
#17
REVIEW
Ahmet Bilici
Pancreatic neuroendocrine tumors (pNETs) are rare and heterogenous tumors and surgery to remove the primary tumor is the mainstay of treatment for resectable disease. However, curative surgery is often not feasible, because half of patients with pNET have metastases at the time of diagnosis. Palliative dubulking surgery and liver-directed therapies are appropriate options for these patients. Streptozocin-based regimens are standard, although temozolamide-based treatments are rapidly gaining wide clinical application...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/25808605/molecular-signalling-pathways-in-canine-gliomas
#18
C E Boudreau, D York, R J Higgins, R A LeCouteur, P J Dickinson
In this study, we determined the expression of key signalling pathway proteins TP53, MDM2, P21, AKT, PTEN, RB1, P16, MTOR and MAPK in canine gliomas using western blotting. Protein expression was defined in three canine astrocytic glioma cell lines treated with CCNU, temozolamide or CPT-11 and was further evaluated in 22 spontaneous gliomas including high and low grade astrocytomas, high grade oligodendrogliomas and mixed oligoastrocytomas. Response to chemotherapeutic agents and cell survival were similar to that reported in human glioma cell lines...
March 25, 2015: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/25252096/irinotecan-and-temozolamide-treatment-for-relapsed-ewing-sarcoma-a-single-center-experience-and-review-of-the-literature
#19
REVIEW
Nilgun Kurucu, Neriman Sari, Inci Ergurhan Ilhan
Long-term survival in relapsed Ewing sarcoma (ES) is less than 20%. Encouraging results have been reported with irinotecan and temozolomide combinations (IRN/TMZ). We aimed to share our experience and compare it with previously published studies using this combination to treat relapsed ES. We retrospectively evaluated 20 patients treated with a combination of IRN (20 mg/m(2)/d × 5 for 2 weeks) and temozolomide (100 mg/m(2)/d × 5). Patients received a total of 97 courses. An objective response was achieved in 11 patients (55%) and maintained for a median of 12 months...
February 2015: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/25083296/outcomes-of-patients-treated-with-capecitabine-and-temozolamide-for-advanced-pancreatic-neuroendocrine-tumors-pnets-and-non-pnets
#20
Renata D'Alpino Peixoto, Krista L Noonan, Peter Pavlovich, Hagen F Kennecke, Howard J Lim
BACKGROUND: Retrospective studies have demonstrated high response rates among patients with advanced pancreatic neuroendocrine tumors (PNETs) treated with capecitabine and temozolamide (CapTem), while responses are infrequently seen among non-PNETs. The objective of the study was to describe progression free survival (PFS) among neuroendocrine tumor (NET) patients treated with CapTem, and to identify factors associated with better activity. METHODS: Patients who were referred to one of five provincial cancer treatment centers between 2009 and 2013 for advanced NETs and initiated CapTem were included...
August 2014: Journal of Gastrointestinal Oncology
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