XiaoHui Zhao, JinPing Cheng, Shushu Gui, Meng Jiang, Dawei Qi, Jianghua Huang, Liren Fu, Shijie Liu, Yujia Ma, Juntian Shi, Zairui Wang, Weike Zeng, Xiumei Li, Kejia Liu, Yamei Tang
Radiation-induced brain injury (RIBI) is a severe, irreversible, or even life-threatening cerebral complication of radiotherapy in patients with head and neck tumors, and there is no satisfying prevention and effective treatment available for these patients. Amifostine (AMF) is a well-known free radical scavenger with demonstrated effectiveness in preventing radiation-induced toxicity. However, the limited permeability of AMF across the blood-brain barrier (BBB) when administered intravenously reduces the effectiveness of AMF in preventing RIBI...
March 14, 2023: ACS Applied Materials & Interfaces