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Xuan Zhou, Wei Zhu, Margaret Nowicki, Shida Miao, Haitao Cui, Benjamin Holmes, Robert I Glazer, Lijie Grace Zhang
Metastasis is one of the deadliest consequences of breast cancer, with bone being one of the primary sites of occurrence. Insufficient 3D biomimetic models currently exist to replicate this process in vitro. In this study, we developed a biomimetic bone matrix using 3D bioprinting technology to investigate the interaction between breast cancer (BrCa) cells and bone stromal cells (fetal osteoblasts and human bone marrow mesenchymal stem cells (MSCs)). A tabletop stereolithography 3D bioprinter was employed to fabricate a series of bone matrices consisting of osteoblasts/MSCs encapsulated in gelatin methacrylate (GelMA) hydrogel with nanocrystalline hydroxyapatite (nHA)...
October 21, 2016: ACS Applied Materials & Interfaces
Brian J Johnson, Tim Hurst, Hung Luu Quoc, Isik Unlu, Christopher Freebairn, Ary Faraji, Scott A Ritchie
We report on the use of the Gravid Aedes Trap (GAT) as a surveillance device for Aedes albopictus (Skuse) relative to the BG-Sentinel (BGS) trap in field studies conducted in Trenton, NJ, and on Hammond Island, Queensland, Australia. A parallel study conducted in Nha Trang, Vietnam, assessed the use of the GAT as an indoor surveillance device as well as the use of canola oil as a noninsecticide killing agent. In Trenton and Hammond Island, the GAT collected fewer male (0.40 ± 0.12 and 0.43 ± 0.30, respectively) and female (3...
October 5, 2016: Journal of Medical Entomology
Seyed Mohammad Davachi, Behzad Shiroud Heidari, Iman Hejazi, Javad Seyfi, Erfan Oliaei, Arman Farzaneh, Hamid Rashedi
In this study, an optimized interface-modified ternary blend with antibacterial activity based on polylactic acid/starch/poly ε-caprolactone (PLASCL20), mixed with nano hydroxyapatite (nHA) via melt blending. This method results in a homogeneous nanocomposite blend in which the addition of 3% nHA improves the overall properties such as hydrolytic degradation, hydrophilicity, antibacterial activity and the drug release comparing to PLASCL20. Moreover, the simultaneous use of nHA and encapsulated triclosan (LATC30) compensated the negative effect of triclosan through increasing the possible cell attachment...
January 2, 2017: Carbohydrate Polymers
Xi Chen, Shizhu Bai, Bei Li, Huan Liu, Guofeng Wu, Sha Liu, Yimin Zhao
INTRODUCTION: Periodontitis is a chronic infectious disease and is the major cause of tooth loss and other oral health issues around the world. Periodontal tissue regeneration has therefore always been the ultimate goal of dentists and researchers. Existing fabrication methods mainly focused on a top-down tissue engineering strategy in which several drawbacks remain, including low throughput and limited diffusion properties resulting from a large sample size. Gelatin methacrylate (GelMA) is a kind of photocrosslinkable and biocompatible hydrogel, with the capacities of enabling cell encapsulation and regeneration of functional tissues...
2016: International Journal of Nanomedicine
Roza Haghgoo, Motahare Ahmadvand, Sareh Moshaverinia
INTRODUCTION: NovaMin is a synthetic mineral compound composed of calcium, sodium, phosphorus, and silica. It releases crystalline hydroxyl-carbonate apatite (HCA), which structurally resembles the minerals naturally found in the teeth. Nano-hydroxyapatite (NHA) is a biocompatible compound with high affinity for tooth enamel. NHA particles morphologically resemble dental enamel apatite crystals. Considering the efficacy of remineralizing agents and the importance of conservative preventive measures, this study aimed to compare the remin-eralizing effects of NovaMin and NHA on caries-like lesions in primary teeth...
2016: Journal of Contemporary Dental Practice
Shu He, Kai-Feng Lin, Jun-Jun Fan, Gang Hu, Xin Dong, Yi-Nan Zhao, Yue Song, Zhong-Shang Guo, Long Bi, Jian Liu
A microsphere composite made of poly(DL-lactic-co-glycolic acid) (PLGA), mesoporous silica nanoparticle (MSN), and nanohydroxyapatite (nHA) (PLGA-MSN/nHA) was prepared and evaluated as bone tissue engineering materials. The objective of this study was to investigate the synergistic effect of MSN/nHA on biocompatibility as well as its potential ability for bone formation. First, we found that this PLGA-MSN/nHA composite performed good characteristics on microstructure, mechanical strength, and wettability. By cell culture experiments, the adhesion and proliferation rate of the cells seeded on PLGA-MSN/nHA composite was higher than those of the controls and high levels of osteogenetic factors such as ALP and Runx-2 were detected by reverse transcriptase polymerase chain reaction...
2016: BioMed Research International
Thanh Nha Uyen, Kazuo Sakashita, Lika'a Fasih Y Al-Kzayer, Yozo Nakazawa, Takashi Kurata, Kenichi Koike
BACKGROUND: The outcome of approximately 20% of patients with acute lymphoblastic leukemia (ALL) remains poor because of disease recurrence. We examined whether DNA methylation of cadherin superfamily genes is a useful biomarker for ALL relapse. PROCEDURE: We used Infinium Methylation 450K Arrays to assess genome-wide DNA methylation status. The methylation status of each individual gene was then determined by a combination of bisulfite restriction analysis and genome bisulfite sequencing...
September 19, 2016: Pediatric Blood & Cancer
Andrew Burkett, Niamh Coffey, Eva Tomiak, Nha Voduc
Birt-Hogg-Dube syndrome (BHDS) is a rare form of classically cystic lung disease that may present with spontaneous pneumothorax. The associated skin manifestations (fibrofolliculomas) are not always present. This article describes a case of spontaneous pneumothorax secondary to bullous emphysema in an otherwise healthy gentleman caused by a novel mutation in the folliculin (FLCN) gene.
2016: Respiratory Medicine Case Reports
Sarit Kumar Rout, Jalandhar Pradhan, Sarmistha Choudhury
UNLABELLED: India has made insignificant progress towards achieving universal access to sexual and reproductive health (SRH). One of the key inputs for achieving universal access to SRH is financial resources. Given this, many international agencies including the UN are emphasising on monitoring the financial progress towards achieving SRH. OBJECTIVE: To generate evidence on spending on SRH from various sources - (government, household, international donors and NGOs) to improve the accountability of the government towards SRH goal...
October 2016: Sexual & Reproductive Healthcare: Official Journal of the Swedish Association of Midwives
Sofya Zvonareva, Yuri Kantor
Gastropod molluscs are one of the most important components of mangrove ecosystem. Mangroves in Central Vietnam have a rather limited distribution due to peculiarities of the coastline morphology and presently their fauna remains understudied. Extensive surveys were conducted in both natural vegetation and artificial mangrove plantations in several localities in Nha Trang Bay from 2005 to 2015. In total 65 species of gastropod molluscs were found alive, 17 of which can be considered as predominantly mangrove-associated...
2016: Zootaxa
Nitin Sagar, Kunal Khanna, Varda S Sardesai, Atul K Singh, Mayur Temgire, Mridula Phukan Kalita, Sachin S Kadam, Vivek P Soni, Deepa Bhartiya, Jayesh R Bellare
Bioactive 3D composites play an important role in advanced biomaterial design to provide molecular coupling and improve integrity with the cellular environment of the native bone. In the present study, a hybrid lyophilized polymer composite blend of anionic charged sodium salt of carboxymethyl chitin and gelatin (CMChNa-GEL) reinforced with nano-rod agglomerated hydroxyapatite (nHA) has been developed with enhanced biocompatibility and tunable elasticity. The scaffolds have an open, uniform and interconnected porous structure with an average pore diameter of 157±30μm and 89...
December 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
Suren P Uswatta, Israel U Okeke, Ambalangodage C Jayasuriya
In this study we have fabricated porous injectable spherical scaffolds using chitosan biopolymer, sodium tripolyphosphate (TPP) and nano-hydroxyapatite (nHA). TPP was primarily used as an ionic crosslinker to crosslink nHA/chitosan droplets. We hypothesized that incorporating nHA into chitosan could support osteoconduction by emulating the mineralized cortical bone structure, and improve the Ultimate Compressive Strength (UCS) of the scaffolds. We prepared chitosan solutions with 0.5%, 1% and 2% (w/v) nHA concentration and used simple coacervation and lyophilization techniques to obtain spherical scaffolds...
December 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
Loan Phuong Do, Miho Kaneko, Toyoko Nakagomi, Punita Gauchan, Chantal Ama Agbemabiese, Anh Duc Dang, Osamu Nakagomi
Rotavirus A (RVA) causes acute diarrhoea in children as well as animals. As part of a cross-sectional study of children less than 5 years of age hospitalised for acute diarrhoea in Vietnam during a 15-month period (2007-2008), 322 (43.5%) of 741 faecal specimens contained RVA with 92% either G1P[8] or G3P[8]. This study was undertaken to further characterise strains that remained untypeable to complete the G and P genotypes of the 322 rotavirus-positive specimens. While 307 (95.3%) strains possessed the common human RVA genotypes: G1P[8] (45...
September 9, 2016: Journal of Medical Virology
Xuan Zhou, Nathan J Castro, Wei Zhu, Haitao Cui, Mitra Aliabouzar, Kausik Sarkar, Lijie Grace Zhang
3D printing and ultrasound techniques are showing great promise in the evolution of human musculoskeletal tissue repair and regeneration medicine. The uniqueness of the present study was to combine low intensity pulsed ultrasound (LIPUS) and advanced 3D printing techniques to synergistically improve growth and osteogenic differentiation of human mesenchymal stem cells (MSC). Specifically, polyethylene glycol diacrylate bioinks containing cell adhesive Arginine-Glycine-Aspartic acid-Serene (RGDS) peptide and/or nanocrystalline hydroxyapatite (nHA) were used to fabricate 3D scaffolds with different geometric patterns via novel table-top stereolithography 3D printer...
2016: Scientific Reports
Shiwei Song, Abul Fajol, Xiankun Tu, Baogang Ren, Songsheng Shi
In human cancers, miRNAs are important regulators of multiple cellular processes, and aberrant miRNA expression has been observed, and their alterations contribute to multiple cancer development and progression. Till now, little has been known about the role of miR-204 in human glioblastoma (GBM). In the present study, we used in-vitro assays to investigate the mechanisms of miR-204 in GBM cell lines and 60 cases of GBM tissues. Here, we found that miR-204 expression is downregulated in both GBM cell lines A172, U87 and U251 cells and GBM tissues as compared with NHA cells and normal tissues (all p<0...
August 31, 2016: Oncotarget
Jianguo Liao, Yongxiang Zhang, Xiali Guan, Jingxian Liu, Nian Shan, Yanqun Li, Yufen Xie, Haohuai Liu
In this work, we investigate the enhanced mechanical properties of nano-hydroxyapatite/polyamide 66 (nHA/PA66) composites reinforced with multi-walled carbon nanotubes (MWCNTs) by means of the blending method. The MWCNTs-nHA/PA66 composites were characterized by various techniques, and the obtained results indicated that the MWCNTs were evenly distributed in the composite and that good interfacial bonding was formed between MWCNTs and PA66. The addition of MWCNTs improved the crystallinity of PA66, while it had little or no effect either on the composition or on the crystal structure of the composites...
November 2016: Journal of Biomaterials Science. Polymer Edition
Gráinne M Cunniffe, Caroline M Curtin, Emmet M Thompson, Glenn R Dickson, Fergal J O'Brien
The use of collagen-based scaffolds in orthopedic applications has been limited due to poor mechanical properties, but this may be overcome by the introduction of a stiffer supporting phase. Thus, we developed a synthesis technique to produce nonaggregating, stable nanohydroxyapatite (nHA) particles, permitting the fabrication of biomimetic-inspired scaffolds through the combination of nanosized HA with collagen, as found in native bone. This study evaluates the mechanical and biological impact of incorporating increasing concentrations of these nanoparticles into porous collagen scaffolds (1:1 and 5:1 weight ratios of nHA/collagen)...
September 14, 2016: ACS Applied Materials & Interfaces
Hirotomo Yamanashi, Mai Quang Ngoc, Tran Van Huy, Motoi Suzuki, Akira Tsujino, Michiko Toizumi, Kensuke Takahashi, Vu Dinh Thiem, Dang Duc Anh, Nguyen Thi Hien Anh, Le Huu Tho, Takahiro Maeda, Sharon E Cox, Lay-Myint Yoshida, Koya Ariyoshi
INTRODUCTION: Stroke incidence data with methodologically acceptable design in Southeast Asia countries is limited. This study aimed to determine incidence of age-, sex- and subtype-specific first-ever stroke (FES) in Vietnam. METHODS: We conducted a hospital-based retrospective study, targeting all stroke cases hospitalized at a solo-provider hospital in our study site of Nha Trang from January 2009 to December 2011 with International Classification of Diseases, 10th revision (ICD-10) codes I60-69...
2016: PloS One
B Kurowicka, M Chrusciel, A Zmijewska, G Kotwica
This study aimed to evaluate the effect of heat acclimation of neonatal and adult rats on their testes response to in vitro treatment with triiodothyronine (T3). Four groups of rats were housed from birth as: 1) control (CR) at 20°C for 90 days, 2) neonatal heat-acclimated (NHA) at 34°C for 90 days, 3) adult heat-acclimated (AHA) at 20°C for 45 days followed by 45 days at 34°C and 4) de-acclimated (DA) at 34°C for 45 days followed by 45 days at 20°C. Blood plasma and both testes were harvested from 90-day old rats...
2016: Polish Journal of Veterinary Sciences
Shiyang Zhang, Qiming Yang, Weikang Zhao, Bo Qiao, Hongwang Cui, Jianjun Fan, Hong Li, Xiaolin Tu, Dianming Jiang
Graphene and its derivatives have been receiving increasing attention regarding their application in bone tissue engineering because of their excellent characteristics, such as a vast specific surface area and excellent mechanical properties. In this study, graphene-reinforced nanohydroxyapatite/polyamide66 (nHA/PA66) bone screws were prepared. The results of scanning electron microscopy observation and X-ray diffraction data showed that both graphene and nHA had good dispersion in the PA66 matrix. In addition, the tensile strength and elastic modulus of the composites were significantly improved by 49...
2016: International Journal of Nanomedicine
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