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https://www.readbyqxmd.com/read/29329077/nano-hydroxyapatite-blasted-titanium-surface-creates-a-biointerface-able-to-govern-src-dependent-osteoblast-metabolism-as-prerequisite-to-ecm-remodeling
#1
Célio J C Fernandes, Fábio Bezerra, Marcel R Ferreira, Amanda F C Andrade, Thais Silva Pinto, Willian F Zambuzzi
Over the last several years, we have focused on the importance of intracellular signaling pathways in dynamically governing the biointerface between pre-osteoblast and surface of biomaterial. Thus, this study investigates the molecular hallmarks involved in the pre-osteoblast relationship with different topography considering Machined (Mc), Dual Acid-Etching (DAE), and nano hydroxyapatite-blasted (nHA) groups. There was substantial differences in topography of titanium surface, considering Atomic Force Microscopy and water contact angle (Mc = 81...
December 28, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29320163/reaction-intermediates-of-nitric-oxide-synthase-from-deinococcus-radiodurans-as-revealed-by-pulse-radiolysis-evidence-for-intramo-lecular-electron-transfer-from-biopterin-to-feii-o2-complex
#2
Yuko Tsutsui, Kazuo Kobayashi, Fusako Takeuchi, Motonari Tsubaki, Takahiro Kozawa
Nitric oxide synthase (NOS) is a cytochrome P450-type mono-oxygenase that catalyzes the oxidation of L-arginine (Arg) to nitric oxide (NO) through a reaction intermediate N-hydroxy-L-arginine (NHA). The mechanism underlying the reaction catalyzed by NOS from Deinococcus radiodurans was investigated using pulse radiolysis. Radiolytically-generated hydrated electrons reduced the heme iron of NOS within 2 μs. Subsequently, ferrous heme reacted with O2 to form a ferrous-dioxygen intermediated with a second-order rate constant of 2...
January 10, 2018: Biochemistry
https://www.readbyqxmd.com/read/29313471/epidemiological-serological-and-virological-features-of-dengue-in-nha-trang-city-vietnam
#3
Duong Le Quyen, Nguyen Thanh Le, Cao Thi Van Anh, Nguyen Binh Nguyen, Dong Van Hoang, Jacqui L Montgomery, Simon C Kutcher, Nguyen Hoang Le, Nguyen Tran Hien, Duong Thi Hue Kien, Maia Rabaa, Scott L O'Neill, Cameron P Simmons, Dang Duc Anh, Katherine L Anders
Vietnam is endemic for dengue. We conducted a series of retrospective and prospective studies to characterize the epidemiology of dengue and population mobility patterns in Nha Trang city, Vietnam, with a view to rational design of trials of community-level interventions. A 10-year time series of dengue case notifications showed pronounced interannual variability, as well as spatial heterogeneity in ward-level dengue incidence (median annual coefficient of variation k = 0.47). Of 451 children aged 1-10 years enrolled in a cross-sectional serosurvey, almost one-third had evidence of a past dengue virus (DENV) infection, with older children more likely to have a multitypic response indicative of past exposure to ≥ 1 serotype...
January 8, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29306083/fabrication-and-characterization-of-highly-porous-barium-titanate-based-scaffold-coated-by-gel-ha-nanocomposite-with-high-piezoelectric-coefficient-for-bone-tissue-engineering-applications
#4
Arian Ehterami, Mansure Kazemi, Bahareh Nazari, Payam Saraeian, Mahmoud Azami
It is well established that the piezoelectric effect plays an important physiological role in bone growth, remodeling and fracture healing. Barium titanate, as a well-known piezoelectric ceramic, is especially an attractive material as a scaffold for bone tissue engineering applications. In this regard, we tried to fabricate a highly porous barium titanate based scaffolds by foam replication method and polarize them by applying an external electric field. In order to enhance the mechanical and biological properties, polarized/non-polarized scaffolds were coated with gelatin and nanostructured HA and characterized for their morphologies, porosities, piezoelectric and mechanical properties...
December 30, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29304281/transferrable-plasmonic-au-thin-film-containing-sub-20-nm-nanohole-array-constructed-via-high-resolution-polymer-self-assembly-and-nanotransfer-printing
#5
Soonmin Yim, Suwan Jeon, Jong Min Kim, Kwang Min Baek, Gun Ho Lee, Hyowook Kim, Jonghwa Shin, Yeon Sik Jung
The fabrication and characterization of nanoscale hole arrays (NHA) have been extensively performed for a variety of unique characteristics including extraordinary optical transmission phenomenon observed for plasmonic NHAs. Although the size miniaturization and hole densification are strongly required for enhancement of high-frequency optical responses, from a practical point-of-view, it is still not straightforward to manufacture NHA using conventional lithography techniques. Herein, a facile, cost-effective, and transferrable fabrication route for high-resolution and high-density NHA with sub-50 nm periodicity is demonstrated...
January 5, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29298461/distal-femoral-varus-osteotomy-for-valgus-arthritis-of-the-knees-systematic-review-of-open-versus-closed-wedge-osteotomy
#6
REVIEW
Young Chan Kim, Jae-Hyuk Yang, Hyun Jung Kim, Tulyapruek Tawonsawatruk, Yong Suk Chang, Jong Seong Lee, Nikhil N Bhandare, Ki Seong Kim, Giorgio D G Delgado, Kyung Wook Nha
Purpose: The purpose of this review is to compare the clinical and radiological outcomes between open and closed wedge distal femoral varus osteotomy (DFO). Methods: A literature search of online databases (MEDLINE, EMBASE, and Cochrane Library database) was made in addition to manual search of major orthopedic journals. Data were searched from the time period of January 1990 to October 2016. A modified Coleman Methodology Score system was used to assess the methodologic quality of the included studies...
January 4, 2018: Knee Surgery & related Research
https://www.readbyqxmd.com/read/29285090/application-of-silk-fibroin-chitosan-nano-hydroxyapatite-composite-scaffold-in-the-repair-of-rabbit-radial-bone-defect
#7
Peng Ye, Bin Yu, Jiang Deng, Rong-Feng She, Wen-Liang Huang
Silk fibroin (SF), chitosan (CS) and nano-hydroxyapatite (nHA) possess excellent biocompatibility, thus, these were used to construct a SF/CS/nHA composite scaffold. Previously published results identified that this material exhibited satisfactory physical and chemical properties, and therefore qualified as a repair material in bone tissue engineering. The aim of the present study was to investigate the capacity and mechanism of this composite scaffold in repairing bone defects. In total, 45 New Zealand white rabbits were used to model defect in the right radial bone...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29216849/economic-evaluations-of-ergonomic-interventions-preventing-work-related-musculoskeletal-disorders-a-systematic-review-of-organizational-level-interventions
#8
Hélène Sultan-Taïeb, Annick Parent-Lamarche, Aurélie Gaillard, Susan Stock, Nektaria Nicolakakis, Quan Nha Hong, Michel Vezina, Youssouph Coulibaly, Nicole Vézina, Diane Berthelette
BACKGROUND: Work-related musculoskeletal disorders (WMSD) represent a major public health problem and economic burden to employers, workers and health insurance systems. This systematic review had two objectives: (1) to analyze the cost-benefit results of organizational-level ergonomic workplace-based interventions aimed at preventing WMSD, (2) to explore factors related to the implementation process of these interventions (obstacles and facilitating factors) in order to identify whether economic results may be due to a successful or unsuccessful implementation...
December 8, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29208285/hybrid-nanofibers-based-on-poly-caprolactone-gelatin-hydroxyapatite-nanoparticles-loaded-doxycycline-effective-anti-tumoral-and-antibacterial-activity
#9
Ricardo Ramírez-Agudelo, Karina Scheuermann, Alfonso Gala-García, Ana Paula F Monteiro, Ana Delia Pinzón-García, Maria E Cortés, Rubén D Sinisterra
Cancer is one of the leading causes of morbidity and mortality Worldwide, 19.3 million new cancer cases are expected to be identified in 2025. Among the therapeutic arsenal to cancer control one could find the Doxycycline and the nano hydroxyapatite. The Doxycycline (Dox) not only shown antibiotic effect but also exhibits a wide range of pleiotropic therapeutic properties as the control of the invasive and metastatic cancer cells characteristics. The purpose of the present study was to evaluate both cytotoxicity in vitro and antibacterial activity of electrospun Dox-loaded hybrid nanofibrous scaffolds composed by hydroxyapatite nanoparticles (nHA), poly-ε-caprolactone (PCL) and gelatin (Gel) polymers...
February 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29199449/structure-conformation-in-aqueous-solution-and-antimicrobial-activity-of-ulvan-extracted-from-green-seaweed-ulva-reticulata
#10
Thi Thanh Van Tran, Hai Bang Truong, Nguyen Ha Vy Tran, Thi Minh Thu Quach, Thi Nu Nguyen, Minh Ly Bui, Yoshiaki Yuguchi, Thi Thu Thuy Thanh
The aim of this study is to elucidate the structure and investigate the antimicrobial activity of an ulvan obtained by water extraction from green seaweed Ulva reticulata collected at Nha Trang sea of Vietnam by using IR, NMR, SEC-MALLS and SAXS methods. The ulvan is composed of rhamnose, galactose, xylose, manose and glucose (mole ratio Rha: Gal: Xyl: Man: Glu = 1:0.12:0.1:0.06:0.03), uronic acid (22.5%) and sulphate groups (17.6%). Chemically structural determination showed that the ulvan mainly composed of disaccharide [→4)β-D-GlcA(1→4)α-L-Rha3S-(1→]...
December 4, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29154783/involvement-of-monocarboxylate-transporter-1-slc16a1-in-the-uptake-of-l-lactate-in-human-astrocytes
#11
Masaya Ideno, Masaki Kobayashi, Shotaro Sasaki, Yuya Futagi, Katsuya Narumi, Ayako Furugen, Ken Iseki
PURPOSE: Astrocytes, the most abundant glial cells in the central nervous system (CNS), help neurons survive Monocarboxylate transporters (MCTs) are reported to transport l-lactate, which is important for CNS physiology and cognitive function. However, it remains unclear which MCT isoform is functionally expressed by human astrocytes. The aim of this study was to establish the contribution of each MCT isoform to l-lactate transport in human astrocytes. METHODS: The function of l-lactate transport was studied using NHA cells as a human astrocyte model and radiolabeled l-lactate...
November 14, 2017: Life Sciences
https://www.readbyqxmd.com/read/29136531/long-term-effects-of-contrasting-tillage-on-soil-organic-carbon-nitrous-oxide-and-ammonia-emissions-in-a-mediterranean-vertisol-under-different-crop-sequences
#12
Giuseppe Badagliacca, Emilio Benítez, Gaetano Amato, Luigi Badalucco, Dario Giambalvo, Vito Armando Laudicina, Paolo Ruisi
This 2-year study aimed to verify whether the continuous application of no tillage (NT) for over 20years, in comparison with conventional tillage (CT), affects nitrous oxide (N2O) and ammonia (NH3) emissions from a Vertisol and, if so, whether such an effect varies with crop sequence (continuous wheat, WW and wheat after faba bean, FW). To shed light on the mechanisms involved in determining N-gas emissions, soil bulk density, water filled pore space (WFPS), some carbon (C) and nitrogen (N) pools, denitrifying enzyme activity (DEA), and nitrous oxide reductase gene abundance (nosZ gene) were also assessed at 0-15 and 15-30cm soil depth...
November 11, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29128121/occurrence-of-greenhouse-gases-in-the-aquifers-of-the-walloon-region-belgium
#13
Anna Jurado, Alberto V Borges, Estanislao Pujades, Vivien Hakoun, Joël Otten, Kay Knöller, Serge Brouyère
This work aims to (1) identify the most conductive conditions for the generation of greenhouses gases (GHGs) in groundwater (e.g., hydrogeological contexts and geochemical processes) and (2) evaluate the indirect emissions of GHGs from groundwater at a regional scale in Wallonia (Belgium). To this end, nitrous oxide (N2O), methane (CH4) and carbon dioxide (CO2) concentrations and the stable isotopes of nitrate (NO3(-)) and sulphate were monitored in 12 aquifers of the Walloon Region (Belgium). The concentrations of GHGs range from 0...
November 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29101803/composite-scaffolds-loaded-with-bone-mesenchymal-stem-cells-promote-the-repair-of-radial-bone-defects-in-rabbit-model
#14
Shi-Qiang Ruan, Jiang Deng, Ling Yan, Wen-Liang Huang
This study aimed to investigate the efficacy of three-dimensional scaffolds of silk fibroin/chitosan/nano-hydroxyapatite (SF/CS/nHA) and bone marrow derived mesenchymal stem cells (BMSCs) on the repair of long segmental bone defects in rabbits. BMSCs were cultured with SF/CS/nHA in vitro, and cell proliferation, alkaline phosphatase activity and Ca2+ content were examined. A 15mm segmental defect in the radius was generated in 12 New Zealand White rabbits, which were divided randomly into three groups (n=4): experimental group with SF/CS/nHA scaffold of induced BMSCs; control group with SF/CS/nHA scaffold; and blank group without any materials...
November 1, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29079090/n-loss-to-drain-flow-and-n2o-emissions-from-a-corn-soybean-rotation-with-winter-rye
#15
K Gillette, R W Malone, T C Kaspar, L Ma, T B Parkin, D B Jaynes, Q X Fang, J L Hatfield, G W Feyereisen, K C Kersebaum
Anthropogenic perturbation of the global nitrogen cycle and its effects on the environment such as hypoxia in coastal regions and increased N2O emissions is of increasing, multi-disciplinary, worldwide concern, and agricultural production is a major contributor. Only limited studies, however, have simultaneously investigated NO3(-) losses to subsurface drain flow and N2O emissions under corn-soybean production. We used the Root Zone Water Quality Model (RZWQM) to evaluate NO3(-) losses to drain flow and N2O emissions in a corn-soybean system with a winter rye cover crop (CC) in central Iowa over a nine year period...
October 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29075041/deregulated-expression-and-activity-of-farnesyl-diphosphate-synthase-fdps-in-glioblastoma
#16
Mario Abate, Chiara Laezza, Simona Pisanti, Giovanni Torelli, Vincenzo Seneca, Giuseppe Catapano, Francesco Montella, Roberta Ranieri, Maria Notarnicola, Patrizia Gazzerro, Maurizio Bifulco, Elena Ciaglia
Glioblastoma (GBM), the most aggressive brain cancer, is highly dependent on the mevalonate (MVA) pathway for the synthesis of lipid moieties critical for cell proliferation but the function and regulation of key intermediate enzymes like farnesyl-diphosphate synthase (FDPS), up to now, remained unknown. A deregulated expression and activity of FDPS was the central research idea of the present study. FDPS mRNA, protein and enzyme activity were analyzed in a cohort of stage III-IV glioma patients (N = 49) and primary derived cells...
October 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29035127/healing-potential-of-nanohydroxyapatite-gelatin-and-fibrin-platelet-glue-combination-as-tissue-engineered-scaffolds-in-radial-bone-defects-of-rats
#17
Abdolhamid Meimandi-Parizi, Ahmad Oryan, Hojjat Gholipour
Different biomaterials have been used in orthopedic surgery. Evaluation of biomaterials for bone healing promotion has been a wide area of research of the orthopedic field. Sixty critical size defects of 5 mm long were bilaterally created in the radial diaphysis of 30 rats. The animals were randomly divided into six equal groups as empty defect, autograft, nanohydroxyapatite (nHA), Gelatin (Gel)-nHA, fibrin-platelet glue (FPG)-nHA, and Gel-FPG-nHA groups (n = 10 in each group). Radiographs of each forelimb were taken postoperatively on the 1st day and then at the 28th and 56th days post injury...
October 16, 2017: Connective Tissue Research
https://www.readbyqxmd.com/read/29025652/high-activity-chitosan-nano-hydroxyapatite-zoledronic-acid-scaffolds-for-simultaneous-tumor-inhibition-bone-repair-and-infection-eradication
#18
Yao Lu, Mei Li, Lihua Li, Shuzhen Wei, Xiaoming Hu, Xiaolan Wang, Guiqiu Shan, Yu Zhang, Hong Xia, Qingshui Yin
Implanted biomaterials combined tumor inhibition and bone repair property are urgently needed to address the huge bone destruction and the high local recurrence following primary surgery in bone tumor therapy. In this work, a high-activity chitosan/nano hydroxyapatite (CS/nHA) scaffold containing zoledronic acid (CS/nHA/Zol) was prepared with a facile method. The prepared CS/nHA/Zol scaffolds exhibited excellent tumor inhibition property towards giant cell tumor of bone (GCT) in vitro through inducing cells apoptosis by up-regulating pro-apoptosis genes expression and reducing the osteoclastic activity of tumor cells by down-regulating osteoclastic genes...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28993846/-hyaluronan-as-a%C3%A2-key-for-accelerated-wound-healing-in-human-3d-full-thickness-skin-models
#19
L Rüther, L Bolke, G R Schlippe, W A Voss
BACKGROUND: Wound healing can be divided into three phases: (1) exsudation phase, (2) granulation phase, (3) regeneration phase. In particular, the epithelization phase is of great importance in order to quickly reconstitute the natural skin barrier. The aim of the present study was to determine the reepithelization kinetics of untreated and 0.5% sodium hyaluronate (NHA) treated human 3D full thickness skin models. MATERIALS AND METHODS: The test protocol consisted of topically applying 10 µl of the test substance 0...
October 9, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28976827/exploring-pressures-tissue-reperfusion-and-body-positioning-a-pilot-evaluation
#20
F Coyer, M Clark, P Slattery, P Thomas, G McNamara, C Edwards, J Ingleman, J Stephenson, K Ousey
OBJECTIVE: To assess the relationship in healthy adults and critically ill patients between: patient position, body mass index (BMI), patient body temperature, interface pressure (IP) and tissue reperfusion (TR). Also to determine the relationship in critically ill patients between: Sequential Organ Failure Assessment (SOFA) score, Braden Scale score for predicting pressure injury risk, Acute Physiology and Chronic Health Evaluation II (APACHE II) severity of disease classification score, IP and TR...
October 2, 2017: Journal of Wound Care
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