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https://www.readbyqxmd.com/read/28231645/the-effect-of-different-sagittal-angles-of-the-tibial-guide-on-aperture-widening-of-the-tibial-tunnel-during-modified-transtibial-anterior-cruciate-ligament-reconstruction-a-randomized-in-vivo-study
#1
Young Chan Kim, Tulyapruek Tawonsawatruk, Hyeong Hwa Woon, Ji Woong Yum, Myung Jin Shin, Rodolfo S Bravo, Kyung Wook Nha
Purpose: The effect of sagittal plane angle of the tibial tunnel on the severity of tibial intra-articular aperture expansion caused by iatrogenic re-reaming in anterior cruciate ligament (ACL) reconstruction using a modified transtibial technique is unknown. The purpose of this study was to compare the severity of intra-articular aperture widening at different angles (40°, 45°, and 50°) of the tibial guide (TG). Materials and Methods: Ninety-seven patients who underwent modified transtibial ACL reconstruction were randomly allocated to TG 40°, 45°, and 50° groups...
March 1, 2017: Knee Surgery & related Research
https://www.readbyqxmd.com/read/28223126/targeted-inhibition-of-hdac8-increases-the-doxorubicin-sensitivity-of-neuroblastoma-cells-via-up-regulation-of-mir-137
#2
Gang Zhao, Guoliang Wang, Hongmin Bai, Tiandong Li, Fanghe Gong, Huan Yang, Jinchong Wen, Weimin Wang
Histone deacetylases (HDACs) have been suggested to be potential therapeutic targets for cancer treatment. Recent studies revealed that HDAC8 expression was associated with poor prognostic markers and poor overall survival rate of neuroblastoma (NB). Our present study revealed that among the four members of class I HDACs, HDAC8 is significantly over expressed in NB cells as compared with the normal fibroblast 3T3 cells or primary normal human astrocytes (NHA) cells. Targeted inhibition of HDAC8 by its specific siRNA (si-HDAC8) can inhibit the in vitro growth of NB cells...
February 18, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28222045/validation-of-scaffold-design-optimization-in-bone-tissue-engineering-finite-element-modeling-versus-designed-experiments
#3
Nicholas Uth, Jens Mueller, Byran Smucker, Azizeh-Mitra Yousefi
This study reports the development of biological/synthetic scaffolds for bone tissue engineering (TE) via 3D bioplotting. These scaffolds were composed of poly(L-lactic-co-glycolic acid) (PLGA), type I collagen, and nano-hydroxyapatite (nHA) in an attempt to mimic the extracellular matrix of bone. The solvent used for processing the scaffolds was 1,1,1,3,3,3-hexafluoro-2-propanol. The produced scaffolds were characterized by scanning electron microscopy, microcomputed tomography, thermogravimetric analysis, and unconfined compression test...
February 21, 2017: Biofabrication
https://www.readbyqxmd.com/read/28220723/ethical-issues-surrounding-the-use-of-modern-human-remains-for-research-in-south-africa
#4
N Briers, J J Dempers
Chapter 8 of the South African National Health Act 61 of 2003 (NHA) that deals with the donation of human tissue was promulgated in 2012. The new Act is perceived to impose restrictions on low-risk research involving human remains. This study aimed to identify the issues raised by a research ethics committee (REC) when reviewing protocols where human remains are used as data source. REC minutes from 2009 to 2014 were reviewed, and issues raised by the committee were categorized. In total, 127 protocols submitted to the committee over 6 years involved human remains...
February 2017: Journal of Empirical Research on Human Research Ethics: JERHRE
https://www.readbyqxmd.com/read/28220190/open-wedge-high-tibial-osteotomy-versus-unicompartmental-knee-arthroplasty-no-difference-in-progression-of-patellofemoral-joint-arthritis
#5
Kwang-Jun Oh, Young Chan Kim, Jong Seong Lee, Yong Suk Chang, Gautam M Shetty, Kyung Wook Nha
PURPOSE: The purpose of this retrospective comparative study was to evaluate and compare, radiographically and clinically, progression of osteoarthritis (OA) in the patellofemoral (PF) compartment after open-wedge high tibial osteotomy (OWHTO), and unicompartmental knee arthroplasty (UKA) over a minimum follow-up of 5 years. METHODS: In this study, 42 knees in an OWHTO group were compared with 59 knees in a UKA group in terms of radiographic parameters, such as the grading system for OA progression in the PF compartment, and clinical parameters, such as the PF pain and function scores over a minimum follow-up of 5 years...
February 20, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28187650/amended-diagnosis-of-the-genus-i-nannodiaptomus-i-copepoda-calanoida-%C3%A2-based-on-redescription-of-i-n-phongnhaensis-i-and-description-of-a-new-species-from-caves-in-central-vietnam
#6
Duc Luong Tran, Anton Brancelj
Nannodiaptomus phongnhaensis Dang & Ho, 2001, an endemic stygobiotic diaptomid from Vietnam and the type species of the genus Nannodiaptomus Dang & Ho, 2001, is redescribed on the basis of a new material from its type locality: Hang Phong Nha Cave, Quang Binh province, central Vietnam. We also designated a neotype, because the type material has been lost. The diagnosis of the genus is amended, based on the description of the neotype. The taxonomic position of the genus in the subfamily Speodiaptominae is proposed, and its relationships with other genera of this subfamily are discussed...
January 19, 2017: Zootaxa
https://www.readbyqxmd.com/read/28187630/sternaspidae-annelida-sedentaria-from-vietnam-with-description-of-three-new-species-and-clarification-of-some-morphological-features
#7
Anna E Zhadan, Alexander B Tzetlin, Sergio I Salazar-Vallejo
Five sternaspid species were found near Vietnam shores: Sternaspis britayevi sp. nov., S. costata von Marenzeller, 1879, S. nana sp. nov., S. papillosa sp. nov., and S. spinosa Sluiter 1882. Sternaspis britayevi is described from the shallow water in Vietnam inhabiting soft bottoms; it resembles S. spinosa described from Java and S. thorsoni Sendall & Salazar-Vallejo, 2013 described from the Persian Gulf, but differs in having a medially projected and markedly ribbed fan of the ventro-caudal shield and nearly parallel, distally widened and rounded branchial plates...
January 25, 2017: Zootaxa
https://www.readbyqxmd.com/read/28152379/selective-transduction-of-astrocytic-and-neuronal-cns-subpopulations-by-lentiviral-vectors-pseudotyped-with-chikungunya-virus-envelope
#8
Ioanna Eleftheriadou, Michael Dieringer, Xuan Ying Poh, Julia Sanchez-Garrido, Yunan Gao, Argyro Sgourou, Laura E Simmons, Nicholas D Mazarakis
Lentiviral vectors are gene delivery vehicles that integrate into the host genome of dividing and non-dividing mammalian cells facilitating long-term transgene expression. Lentiviral vector versatility is greatly increased by incorporating heterologous viral envelope proteins onto the vector particles instead of the native envelope, conferring on these pseudotyped vectors a modified tropism and host range specificity. We investigated the pseudotyping efficiency of HIV-1 based lentiviral vectors with alphaviral envelope proteins from the Chikungunya Virus (CHIKV-G) and Sindbis Virus (SINV-G)...
January 23, 2017: Biomaterials
https://www.readbyqxmd.com/read/28140360/assembling-of-electrospun-meshes-into-three-dimensional-porous-scaffolds-for-bone-repair
#9
Juqing Song, Guanglin Zhu, Lin Wang, Geng An, Xuetao Shi, Yingjun Wang
Technical limitations of traditional electrospinning make it hard to produce three-dimensional (3D) scaffolds with hierarchical pore structures. Here, porous polycaprolactone (PCL) nanofiber meshes with different nano-hydroxyapatite (nHA) concentrations were prepared by electrospinning with stainless steel mesh as the collector, and 3D porous nanofiber scaffolds were fabricated via layer-by-layer assembly with a special binder (18% PCL/DCM solution). The single layer nanofiber mesh possessed very regular morphology with a hollow structure, and the nHA was not only embedded in the nanofiber but also exposed on the surfaces of the fiber, resulting in the improved surface chemical properties...
February 14, 2017: Biofabrication
https://www.readbyqxmd.com/read/28111719/additive-effects-of-the-herbicide-glyphosate-and-elevated-temperature-on-the-branched-coral-acropora-formosa-in-nha-trang-vietnam
#10
C Amid, M Olstedt, J S Gunnarsson, H Le Lan, H Tran Thi Minh, P J Van den Brink, M Hellström, M Tedengren
The combined effects of the herbicide glyphosate and elevated temperature were studied on the tropical staghorn coral Acropora formosa, in Nha Trang bay, Vietnam. The corals were collected from two different reefs, one close to a polluted fish farm and one in a marine-protected area (MPA). In the laboratory, branches of the corals were exposed to the herbicide glyphosate at ambient (28 °C) and at 3 °C elevated water temperatures (31 °C). Effects of herbicide and elevated temperature were studied on coral bleaching using photography and digital image analysis (new colorimetric method developed here based on grayscale), chlorophyll a analysis, and symbiotic dinoflagellate (Symbiodinium, referred to as zooxanthellae) counts...
January 22, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28103529/improving-osteogenesis-of-three-dimensional-porous-scaffold-based-on-mineralized-recombinant-human-like-collagen-via-mussel-inspired-polydopamine-and-effective-immobilization-of-bmp-2-derived-peptide
#11
Jing Zhou, Xiaodong Guo, Qixin Zheng, Yongchao Wu, Fuzai Cui, Bin Wu
An ideal bone substitute should be biocompatible, biodegradable, osteoinductive and osteoconductive. In our previous work, we fabricated a three-dimensional porous scaffold based on mineralized recombinant human-like collagen, nano-hydroxyapatite/recombinant human-like collagen/poly(lactic acid) (nHA/RHLC/PLA). Like other HA/collagen scaffolds, the nHA/RHLC/PLA scaffold lacked osteoinductive bioactivity. The purpose of the present study was to develop a polydopamine (pDA)-assisted BMP-2-derived peptide (designated as P24) surface modification strategy for improving the osteogenesis of the nHA/RHLC/PLA scaffold...
January 4, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28097054/hydrogel-scaffolds-promote-neural-gene-expression-and-structural-reorganization-in-human-astrocyte-cultures
#12
V Bleu Knight, Elba E Serrano
Biomaterial scaffolds have the potential to enhance neuronal development and regeneration. Understanding the genetic responses of astrocytes and neurons to biomaterials could facilitate the development of synthetic environments that enable the specification of neural tissue organization with engineered scaffolds. In this study, we used high throughput transcriptomic and imaging methods to determine the impact of a hydrogel, PuraMatrix™, on human glial cells in vitro. Parallel studies were undertaken with cells grown in a monolayer environment on tissue culture polystyrene...
2017: PeerJ
https://www.readbyqxmd.com/read/28086775/rapid-decline-in-the-susceptibility-of-plasmodium-falciparum-to-dihydroartemisinin-piperaquine-in-the-south-of-vietnam
#13
Ngo Viet Thanh, Nguyen Thuy-Nhien, Nguyen Thi Kim Tuyen, Nguyen Thanh Tong, Nguyen Thuy Nha-Ca, Le Thanh Dong, Huynh Hong Quang, Jeremy Farrar, Guy Thwaites, Nicholas J White, Marcel Wolbers, Tran Tinh Hien
BACKGROUND: Artemisinin resistant Plasmodium falciparum has emerged in the countries of the Greater Mekong sub-region posing a serious threat to global malaria elimination efforts. The relationship of artemisinin resistance to treatment failure has been unclear. METHODS: In annual studies conducted in three malaria endemic provinces in the south of Vietnam (Binh Phuoc, Ninh Thuan and Gia Lai) between 2011 and 2015, 489 patients with uncomplicated P. falciparum malaria were enrolled in detailed clinical, parasitological and molecular therapeutic response assessments with 42 days follow up...
January 13, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28077456/revealing-nonclassicality-beyond-gaussian-states-via-a-single-marginal-distribution
#14
Jiyong Park, Yao Lu, Jaehak Lee, Yangchao Shen, Kuan Zhang, Shuaining Zhang, Muhammad Suhail Zubairy, Kihwan Kim, Hyunchul Nha
A standard method to obtain information on a quantum state is to measure marginal distributions along many different axes in phase space, which forms a basis of quantum-state tomography. We theoretically propose and experimentally demonstrate a general framework to manifest nonclassicality by observing a single marginal distribution only, which provides a unique insight into nonclassicality and a practical applicability to various quantum systems. Our approach maps the 1D marginal distribution into a factorized 2D distribution by multiplying the measured distribution or the vacuum-state distribution along an orthogonal axis...
January 31, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28056713/three-dimensional-printed-bone-scaffolds-the-role-of-nano-micro-hydroxyapatite-particles-on-the-adhesion-and-differentiation-of-human-mesenchymal-stem-cells
#15
Marco Domingos, Antonio Gloria, Jorge Coelho, Paulo Bartolo, Joaquim Ciurana
Bone tissue engineering is strongly dependent on the use of three-dimensional scaffolds that can act as templates to accommodate cells and support tissue ingrowth. Despite its wide application in tissue engineering research, polycaprolactone presents a very limited ability to induce adhesion, proliferation and osteogenic cell differentiation. To overcome some of these limitations, different calcium phosphates, such as hydroxyapatite and tricalcium phosphate, have been employed with relative success. This work investigates the influence of nano-hydroxyapatite and micro-hydroxyapatite (nHA and mHA, respectively) particles on the in vitro biomechanical performance of polycaprolactone/hydroxyapatite scaffolds...
December 1, 2016: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/28030863/real-world-clinical-practice-of-intensified-chemotherapies-for-metastatic-pancreatic-cancer-results-from-a-pan-european-questionnaire-study
#16
Nha Le, Alessio Vinci, Marvin Schober, Sebastian Krug, Muhammad A Javed, Thomas Kohlmann, Malin Sund, Albrecht Neesse, Georg Beyer
INTRODUCTION: Recently, FOLFIRINOX and gemcitabine + nab-paclitaxel have been introduced as a novel intensified chemotherapy regimen for patients with metastasized pancreatic cancer. This study aims to analyze the real-world clinical practice with FOLFIRINOX and gemcitabine + nab-paclitaxel across Europe. METHODS: Invitations to participate in an anonymous web-based questionnaire were sent via e-mail to 5,420 doctors in 19 European countries through the network of national gastroenterological, oncological, surgical and pancreatic societies as well as the European Pancreatic Club...
2016: Digestion
https://www.readbyqxmd.com/read/28024596/laminated-electrospun-nha-phb-composite-scaffolds-mimicking-bone-extracellular-matrix-for-bone-tissue-engineering
#17
Zhuoyue Chen, Yue Song, Jing Zhang, Wei Liu, Jihong Cui, Hongmin Li, Fulin Chen
Electrospinning is an effective means to generate nano- to micro-scale polymer fibers resembling native extracellular matrix for tissue engineering. However, a major problem of electrospun materials is that limited pore size and porosity may prevent adequate cellular infiltration and tissue ingrowth. In this study, we first prepared thin layers of hydroxyapatite nanoparticle (nHA)/poly-hydroxybutyrate (PHB) via electrospinning. We then laminated the nHA/PHB thin layers to obtain a scaffold for cell seeding and bone tissue engineering...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27989347/effect-of-combined-fibular-osteotomy-on-the-pressure-of-the-tibiotalar-and-talofibular-joints-in-supramalleolar-osteotomy-of-the-ankle-a%C3%A2-cadaveric-study
#18
Gi Won Choi, Soon Hyuck Lee, Kyung Wook Nha, Sung Jae Lee, Won Hyeon Kim, Chang-Sub Uhm
We investigated the effect of combined fibular osteotomy on the pressure of the tibiotalar and talofibular joints in medial opening-wedge supramalleolar osteotomy. Three different tibial osteotomy gaps (6, 8, and 10 mm) were created in 10 cadaveric models, and the pressure in the tibiotalar and talofibular joints was measured under axial load before and after fibular osteotomy. The heel alignment angle and talar translation ratio were evaluated radiographically. An increase in osteotomy gap led to increases in hindfoot valgus (p = ...
January 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/27982185/physico-chemical-and-histomorphometric-evaluation-of-zinc-containing-hydroxyapatite-in-rabbits-calvaria
#19
Alinne Azevedo Pereira da Silva Suruagy, Adriana Terezinha Neves Novellino Alves, Suelen Cristina Sartoretto, José de Albuquerque Calasans-Maia, José Mauro Granjeiro, Mônica Diuana Calasans-Maia
The aim of this study was to characterize the physico-chemical properties and bone repair after implantation of zinc-containing nanostructured porous hydroxyapatite scaffold (nZnHA) in rabbits' calvaria. nZnHA powder containing 2% wt/wt zinc and stoichiometric nanostructured porous hydroxyapatite (nHA - control group) were shaped into disc (8 mm) and calcined at 550 °C. Two surgical defects were created in the calvaria of six rabbits (nZnHA and nHA). After 12 weeks, the animals were euthanized and the grafted area was removed, fixed in 10% formalin with 0...
October 2016: Brazilian Dental Journal
https://www.readbyqxmd.com/read/27981546/lncrna-h19-is-overexpressed-in-glioma-tissue-is-negatively-associated-with-patient-survival-and-promotes-tumor-growth-through-its-derivative-mir-675
#20
T Zhang, Y-R Wang, F Zeng, H-Y Cao, H-D Zhou, Y-J Wang
OBJECTIVE: Glioma is one of the most common and invasive tumors of the central nervous system. Long non-coding (lnc) RNAs are involved in many cancers, but their function and mechanism in glioma remain largely unknown. We wished to delineate the role of lncRNA H19 and its derivative miR-675 in this tumor. PATIENTS AND METHODS: Using qPCR, we compared expression of lncRNA H19 in 35 specimens of glioma vs control tissue, and in two glioma cell lines U251 and U87 vs Normal Human Astrocyte (NHA) cells...
December 2016: European Review for Medical and Pharmacological Sciences
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