keyword
MENU ▼
Read by QxMD icon Read
search

NHA

keyword
https://www.readbyqxmd.com/read/28714236/effectiveness-of-tissue-engineered-three-dimensional-bioactive-graft-on-bone-healing-and-regeneration-an-in-vivo-study-with-significant-clinical-value
#1
Mostafa Shahrezaie, Ali Moshiri, Babak Shekarchi, Ahmad Oryan, Nicola Maffulli, Javad Parvizi
Several strategies have been used to promote bone repair; with many failing due to the lack of osteoinduction. We describe our approach for promoting bone healing that attempts to overcome prior shortcomings. First, we compared the role of different concentrations of Gelatin (Gel), nanostructured-hydroxyapatite (nHA), Simvastatin (Sim) and nHA-Sim particles on healing of small femoral bone defects in rabbits. The effective concentration of each of them was studied, and then a three-dimensional porous scaffold was designed using Gel, nHA and Sim which was then cross-linked with Genipin...
July 17, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28714045/characterization-drug-loading-and-antibacterial-activity-of-nanohydroxyapatite-polycaprolactone-nha-pcl-electrospun-membrane
#2
Mohd Izzat Hassan, Naznin Sultana
Considering the important factor of bioactive nanohydoxyapatite (nHA) to enhance osteoconductivity or bone-bonding capacity, nHA was incorporated into an electrospun polycaprolactone (PCL) membrane using electrospinning techniques. The viscosity of the PCL and nHA/PCL with different concentrations of nHA was measured and the morphology of the electrospun membranes was compared using a field emission scanning electron microscopy. The water contact angle of the nanofiber determined the wettability of the membranes of different concentrations...
August 2017: 3 Biotech
https://www.readbyqxmd.com/read/28692986/heavy-tailed-noise-suppression-and-derivative-wavelet-scalogram-for-detecting-dna-copy-number-aberrations
#3
Nha Nguyen, An Vo, Haibin Sun, Heng Huang
Most existing array comparative genomic hybridization (array CGH) data processing methods and evaluation models assumed that the probability density function of noise in array CGH is a Gaussian distribution. However, in practice such noise distribution is peaky and heavy-tailed. A more accurate and sufficient model of noise in array CGH data is necessary and beneficial to the detection of DNA copy number variations. We analyze the real array CGH data from different platforms and show that the distribution of noise in array CGH data is fitted very well by generalized Gaussian distribution (GGD)...
July 6, 2017: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/28684725/the-influence-of-copolymer-composition-on-plga-nha-scaffolds-cytotoxicity-and-in-vitro-degradation
#4
Esperanza Díaz, Igor Puerto, Silvie Ribeiro, Senentxu Lanceros-Mendez, José Manuel Barandiarán
The influence of copolymer composition on Poly(Lactide-co-Glycolide)/nanohydroxyapatite (PLGA/nHA) composite scaffolds is studied in the context of bone tissue engineering and regenerative medicine. The composite scaffolds are fabricated by thermally-induced phase separation and the effect of bioactive nanoparticles on their in vitro degradation in phosphate-buffered solution at 37 °C is analyzed over eight weeks. The indirect cytotoxicity evaluation of the samples followed an adaptation of the ISO 10993-5 standard test method...
July 6, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28668749/spruce-fir-forest-changes-during-a-30-year-nitrogen-saturation-experiment
#5
Steven G McNulty, Johnny L Boggs, John D Aber, Lindsey E Rustad
A field experiment was established in a high elevation red spruce (Picea rubens Sarg.) - balsam fir (Abies balsamea) forest on Mount Ascutney Vermont, USA in 1988 to test the nitrogen (N) saturation hypothesis, and to better understand the mechanisms causing forest decline at the time. The study established replicate control, low and high dose nitrogen addition plots (i.e., 0, 15.7 and 31.4kgNH4Cl-Nha(-1)yr(-1)). The treatments began in 1988 and continued annually until 2010, but monitoring has continued to present...
June 29, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28666210/mir-489-inhibits-proliferation-cell-cycle-progression-and-induces-apoptosis-of-glioma-cells-via-targeting-spin1-mediated-pi3k-akt-pathway
#6
Yan Li, Xiaolin Ma, Yanpeng Wang, Guohua Li
microRNA-489 (miR-489), a newly identified tumor-related miRNA, functions as an oncogene or tumor suppressor via regulating growth and metastasis of human cancers. But, the clinical significance, biological function and underlying mechanisms of miR-489 in glioma remain rarely known. Here, we showed that the levels of miR-489 in glioma tissues were notably underexpressed compared to corresponding non-tumor tissues. In accordance, the relative levels of miR-489 were decreased in glioma cell lines compared with NHA cells...
June 27, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28629069/evaluation-of-electrospun-biomimetic-substrate-surface-decorated-with-nanohydroxyapatite-precipitation-for-osteoblasts-behavior
#7
Sai Zhang, Guojun Jiang, Molamma P Prabhakaran, Xiaohong Qin, Seeram Ramakrishna
To engineer bone tissue, it is crucial to design scaffolds with micro- and nano-sized architecture imitating approximate hierarchical structure of native bone, and afford desirable biological properties by introducing biocompatible polymers and bioceramics into the scaffolds. Here, a novel scaffold consisting of poly-3-hydroxybutyrate-co-3-hydroxyvalerate (PHBV)/polyaspartic acid (PAA) was fabricated by electrospinning and nano-hydroxyapatite (nHA) was deposited by calcium-phosphate dipping process for bone tissue regeneration...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28620549/lamination-of-microfibrous-plga-fabric-by-electrospinning-a-layer-of-collagen-hydroxyapatite-composite-nanofibers-for-bone-tissue-engineering
#8
Gi-Wan Kwon, Kailash Chandra Gupta, Kyung-Hye Jung, Inn-Kyu Kang
BACKGROUND: To mimic the muscle inspired cells adhesion through proteins secretion, the lamination of collagen-hydroxyapatite nanorod (nHA) composite nanofibers has been carried out successfully on polydopamine (PDA)-coated microfibrous polylactide-co-glycolide (PLGA) fabrics. The lamination of collagen-hydroxyapatite composite nanofibers on polydopamine-coated microfibrous PLGA fabrics was carried through electrospinning the solution of collagen containing L-glutamic acid-grafted hydroxyapatite nanorods (nHA-GA) at a flow rate of 1...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/28618469/collisional-dissipation-rate-in-shearing-flows-of-granular-liquid-crystals
#9
Diego Berzi, Nha Thai-Quang, Yu Guo, Jennifer Curtis
We make use of discrete-element-method numerical simulations of inelastic frictionless cylinders in simple shearing at different length-to-diameter ratios and solid volume fractions to analyze the rate of collisional dissipation of the fluctuation kinetic energy. We show that the nonspherical geometry of the particles is responsible, by inducing rotation, for increasing the dissipation rate of the fluctuation kinetic energy with respect to that for frictionless spheres. We also suggest that the partial alignment of the cylinders induced by shearing concurs with the particle inelasticity in generating correlation in the velocity fluctuations and thus affecting the collisional dissipation rate as the solid volume fraction increases...
May 2017: Physical Review. E
https://www.readbyqxmd.com/read/28616703/preparation-of-a-biphase-composite-scaffold-and-its-application-in-tissue-engineering-for-femoral-osteochondral-defects-in-rabbits
#10
Shi-Qiang Ruan, Ling Yan, Jiang Deng, Wen-Liang Huang, Dian-Ming Jiang
PURPOSE: Three-dimensional bioactive scaffolds are useful tools for stem cell implant in tissue-engineering. For chondral and subchondral repair, the chondroinductive and osteoinductive property of a scaffold is a major challenge. The scaffolds that aim to osteogenic differentiation have been well studied. However, cartilage cells can hardly be induced for osteogenesis, and monophase scaffolds cannot ideally repair both cartilage and subchondral defects at the same time. METHODS: We developed a novel biphase composite scaffold and observe its application osteochondral defects...
June 14, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28614360/comparative-genomics-of-cryptococcus-neoformans-var-grubii-associated-with-meningitis-in-hiv-infected-and-uninfected-patients-in-vietnam
#11
COMPARATIVE STUDY
Jeremy N Day, Seet Qihui, Lam Tuan Thanh, Phan Hai Trieu, Anh Duong Van, Nha Hoang Thu, Tran Thi Hong Chau, Nguyen P H Lan, Nguyen Van Vinh Chau, Philip M Ashton, Guy E Thwaites, Maciej F Boni, Marcel Wolbers, Niranjan Nagarajan, Patrick B O Tan, Stephen Baker
The vast burden of cryptococcal meningitis occurs in immunosuppressed patients, driven by HIV, and is caused by Cryptococcus neoformans var. grubii. We previously reported cryptococcal meningitis in Vietnam arising atypically in HIV uninfected, apparently immunocompetent patients, caused by a single amplified fragment length polymorphism (AFLP) cluster of C. neoformans var. grubii (VNIγ). This variant was less common in HIV infected individuals; it remains unclear why this lineage is associated with apparently immunocompetent patients...
June 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28609719/near-infrared-photoluminescence-biosensing-platform-with-gold-nanorods-over-gallium-arsenide-nanohorn-array
#12
Yiming Zhang, Tao Jiang, Longhua Tang
The near-infrared (NIR) optical detection of biomolecules with high sensitivity and reliability have been expected, however, it is still a challenge. In this work, we present a gold nanorods (AuNRs)-over-gallium arsenide nanohorn-like array (GaAs NHA) system that can be used for the ultrasensitive and specific NIR photoluminescence (PL) detection of DNA and proteins. The fabrication of GaAs NHA involved the technique of colloidal lithography and inductively coupled plasma dry etching, yielding large-area and well-defined nanostructural array, and exhibiting an improved PL emission compared to the planar GaAs substrate...
June 7, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28609637/midterm-and-long-term-results-of-medial-versus-lateral-meniscal-allograft-transplantation-a-meta-analysis
#13
Seong-Il Bin, Kyung-Wook Nha, Ji-Young Cheong, Young-Soo Shin
BACKGROUND: It is unclear whether lateral meniscal allograft transplantation (MAT) procedures lead to better clinical outcomes than medial MAT. HYPOTHESIS: The survival rates are similar between medial and lateral MAT, but the clinical outcomes of lateral MAT are better than those of medial MAT at final follow-up. STUDY DESIGN: Meta-analysis. METHODS: In this meta-analysis, we reviewed studies that assessed survival rates in patients who underwent medial or lateral MAT with more than 5 years of follow-up and that used assessments such as pain and Lysholm scores to compare postoperative scores on knee outcome scales...
June 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28584897/effects-of-juice-processing-on-oxalate-contents%C3%A2-in-carambola-juice-products
#14
Nha K Huynh, Ha V H Nguyen
Effects of processing methods including pressing, enzyme-assisted extraction, lactic acid fermentation by Lactobacillus acidophilus, and alcohol fermentation by Saccharomyces cerevisiae on total and soluble oxalate contents of carambola juices were studied. In comparison with pressing, the use of enzyme increased juice yields (15.89-17.29%), but resulted in higher total oxalate (1.60-1.73 times) and soluble oxalate contents (1.16-1.49 times). In addition, extension of enzyme incubation periods led to an increase in soluble oxalate contents in the products (p < 0...
June 6, 2017: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/28569381/lncrna-tp53tg1-participated-in-the-stress-response-under-glucose-deprivation-in-glioma
#15
Xin Chen, Yang Gao, Deheng Li, Bin Hao, Yiqun Cao
Gliomas are the most common brain tumors of the center nervous system. And long non-coding RNAs (lncRNAs) are non-protein coding transcripts, which have been considered as one type of gene expression regulator for cancer development. In this study, we investigated the role of lncRNA-TP53TG1 in response to glucose deprivation in human gliomas. The expression levels of TP53TG1 in glioma tissues and cells were analyzed by qRT-PCR. In addition, the influence of TP53TG1 on glucose metabolism related genes at the mRNA level during both high and low glucose treatment was detected by qRT-PCR...
June 1, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28544201/influence-of-highly-porous-electrospun-plga-pcl-nha-fibrous-scaffolds-on-the-differentiation-of-tooth-bud-cells-in-vitro
#16
Xinjie Cai, Sofie Ten Hoopen, Weibo Zhang, Charles Yi, Wanxun Yang, Fang Yang, John A Jansen, X Frank Walboomers, Pamela C Yelick
In this study, we investigated the use of three-dimensional electrospun poly(lactic-co-glycolic acid)/poly(ε-caprolactone) (PLGA/PCL) scaffolds seeded and cultured with postnatal dental cells, for improved dental tissue regeneration. Wet-electrospinning combined with ultrasonic treatment was studied as a method to enhance scaffold porosity and to promote cell-cell interactions. We also investigated whether nano-hydroxyapatite (nHA) incorporation could enhance dental cell differentiation. All scaffolds were seeded with human tooth pulp-derived dental mesenchymal (hDM) cells, or a combination of hDM and pig dental epithelial (pDE) cells, cultured for up to 28 days...
May 24, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28541005/a-combined-closing-wedge-distal-femoral-osteotomy-and-medial-reefing-procedure-for-recurrent-patellar-dislocation-with-genu-valgum
#17
Chong Bum Chang, Gautam M Shetty, Jong Seong Lee, Young Chan Kim, Jae Ho Kwon, Kyung Wook Nha
PURPOSE: Recurrent patellar dislocation is often associated with genu valgum. The purpose of this study was to analyze the short-term results of single-incision, closing-wedge distal femoral osteotomy (CWDFO) combined with medial reefing and lateral release for recurrent patellar instability with genu valgum. MATERIALS AND METHODS: Combined CWDFO/medial reefing/lateral release was performed on 10 knees. Clinical evaluation was based on pre- and postoperative Knee Society Score (KSS) and Kujala patellofemoral score...
July 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28539234/biodegradable-pcl-fibroin-hydroxyapatite-porous-scaffolds-prepared-by-supercritical-foaming-for-bone-regeneration
#18
Luis Diaz-Gomez, Carlos A García-González, Jiamian Wang, Fang Yang, Salvador Aznar-Cervantes, Jose Luis Cenis, Ricardo Reyes, Araceli Delgado, Carmen Évora, Angel Concheiro, Carmen Alvarez-Lorenzo
Regenerative medicine seeks advanced solutions for bone repair in the form of bioactive synthetic scaffolds by using simple and reproducible processing techniques. In this work, poly-ε-caprolactone (PCL)-based porous scaffolds with improved osteoconductive and osteoinductive properties were processed by supercritical foaming through a careful tuning of components and processing conditions. Composite scaffolds were prepared from various combinations of PCL, silk fibroin and nano-hydroxyapatite (nHA). The green and cost-effective supercritical CO2 foaming method applied rendered solid scaffolds with 67-70% porosity...
May 21, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28532091/design-and-fabrication-of-carbon-fibers-with-needle-like-nano-ha-coating-to-reinforce-granular-nano-ha-composites
#19
Xudong Wang, Xueni Zhao, Li Zhang, Wanying Wang, Jing Zhang, Fuzhen He, Jianjun Yang
Carbon fibers (CFs) with needle-like nano-hydroxyapatite (nHA) coating were first used as reinforcing materials named nHA-CFs to improve the mechanical properties of pure HA. A powder mixture containing nHA-CFs and granular nano-HA (gHA) was directly sintered by hot pressing at appropriate sintering pressure and temperature. A three-phase nHA-CFs/gHA composite was designed, fabricated, and used as an artificial bone. Results show that the bending strengths of the nHA-CFs/gHA composite are approximately 41.1% and 59...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28512712/post-translational-tubulin-modifications-in-human-astrocyte-cultures
#20
V Bleu Knight, Elba E Serrano
The cytoskeletal protein tubulin plays an integral role in the functional specialization of many cell types. In the central nervous system, post-translational modifications and the expression of specific tubulin isotypes in neurons have been analyzed in greater detail than in their astrocytic counterparts. In this study, we characterized post-translational specifications of tubulin in human astrocytes using the normal human astrocyte (NHA; Lonza) commercial cell line of fetal origin. Immunocytochemical techniques were implemented in conjunction with confocal microscopy to image class III β-tubulin (βIII-tubulin), acetylated tubulin, and polyglutamylated tubulin using fluorescent antibody probes...
May 17, 2017: Neurochemical Research
keyword
keyword
35952
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"