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https://www.readbyqxmd.com/read/28629069/evaluation-of-electrospun-biomimetic-substrate-surface-decorated-with-nanohydroxyapatite-precipitation-for-osteoblasts-behavior
#1
Sai Zhang, Guojun Jiang, Molamma P Prabhakaran, Xiaohong Qin, Seeram Ramakrishna
To engineer bone tissue, it is crucial to design scaffolds with micro- and nano-sized architecture imitating approximate hierarchical structure of native bone, and afford desirable biological properties by introducing biocompatible polymers and bioceramics into the scaffolds. Here, a novel scaffold consisting of poly-3-hydroxybutyrate-co-3-hydroxyvalerate (PHBV)/polyaspartic acid (PAA) was fabricated by electrospinning and nano-hydroxyapatite (nHA) was deposited by calcium-phosphate dipping process for bone tissue regeneration...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28620549/lamination-of-microfibrous-plga-fabric-by-electrospinning-a-layer-of-collagen-hydroxyapatite-composite-nanofibers-for-bone-tissue-engineering
#2
Gi-Wan Kwon, Kailash Chandra Gupta, Kyung-Hye Jung, Inn-Kyu Kang
BACKGROUND: To mimic the muscle inspired cells adhesion through proteins secretion, the lamination of collagen-hydroxyapatite nanorod (nHA) composite nanofibers has been carried out successfully on polydopamine (PDA)-coated microfibrous polylactide-co-glycolide (PLGA) fabrics. The lamination of collagen-hydroxyapatite composite nanofibers on polydopamine-coated microfibrous PLGA fabrics was carried through electrospinning the solution of collagen containing L-glutamic acid-grafted hydroxyapatite nanorods (nHA-GA) at a flow rate of 1...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/28618469/collisional-dissipation-rate-in-shearing-flows-of-granular-liquid-crystals
#3
Diego Berzi, Nha Thai-Quang, Yu Guo, Jennifer Curtis
We make use of discrete-element-method numerical simulations of inelastic frictionless cylinders in simple shearing at different length-to-diameter ratios and solid volume fractions to analyze the rate of collisional dissipation of the fluctuation kinetic energy. We show that the nonspherical geometry of the particles is responsible, by inducing rotation, for increasing the dissipation rate of the fluctuation kinetic energy with respect to that for frictionless spheres. We also suggest that the partial alignment of the cylinders induced by shearing concurs with the particle inelasticity in generating correlation in the velocity fluctuations and thus affecting the collisional dissipation rate as the solid volume fraction increases...
May 2017: Physical Review. E
https://www.readbyqxmd.com/read/28616703/preparation-of-a-biphase-composite-scaffold-and-its-application-in-tissue-engineering-for-femoral-osteochondral-defects-in-rabbits
#4
Shi-Qiang Ruan, Ling Yan, Jiang Deng, Wen-Liang Huang, Dian-Ming Jiang
PURPOSE: Three-dimensional bioactive scaffolds are useful tools for stem cell implant in tissue-engineering. For chondral and subchondral repair, the chondroinductive and osteoinductive property of a scaffold is a major challenge. The scaffolds that aim to osteogenic differentiation have been well studied. However, cartilage cells can hardly be induced for osteogenesis, and monophase scaffolds cannot ideally repair both cartilage and subchondral defects at the same time. METHODS: We developed a novel biphase composite scaffold and observe its application osteochondral defects...
June 14, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28614360/comparative-genomics-of-cryptococcus-neoformans-var-grubii-associated-with-meningitis-in-hiv-infected-and-uninfected-patients-in-vietnam
#5
Jeremy N Day, Seet Qihui, Lam Tuan Thanh, Phan Hai Trieu, Anh Duong Van, Nha Hoang Thu, Tran Thi Hong Chau, Nguyen P H Lan, Nguyen Van Vinh Chau, Philip M Ashton, Guy E Thwaites, Maciej F Boni, Marcel Wolbers, Niranjan Nagarajan, Patrick B O Tan, Stephen Baker
The vast burden of cryptococcal meningitis occurs in immunosuppressed patients, driven by HIV, and is caused by Cryptococcus neoformans var. grubii. We previously reported cryptococcal meningitis in Vietnam arising atypically in HIV uninfected, apparently immunocompetent patients, caused by a single amplified fragment length polymorphism (AFLP) cluster of C. neoformans var. grubii (VNIγ). This variant was less common in HIV infected individuals; it remains unclear why this lineage is associated with apparently immunocompetent patients...
June 14, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28609719/near-infrared-photoluminescence-biosensing-platform-with-gold-nanorods-over-gallium-arsenide-nanohorn-array
#6
Yiming Zhang, Tao Jiang, Longhua Tang
The near-infrared (NIR) optical detection of biomolecules with high sensitivity and reliability have been expected, however, it is still a challenge. In this work, we present a gold nanorods (AuNRs)-over-gallium arsenide nanohorn-like array (GaAs NHA) system that can be used for the ultrasensitive and specific NIR photoluminescence (PL) detection of DNA and proteins. The fabrication of GaAs NHA involved the technique of colloidal lithography and inductively coupled plasma dry etching, yielding large-area and well-defined nanostructural array, and exhibiting an improved PL emission compared to the planar GaAs substrate...
June 7, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28609637/midterm-and-long-term-results-of-medial-versus-lateral-meniscal-allograft-transplantation-a-meta-analysis
#7
Seong-Il Bin, Kyung-Wook Nha, Ji-Young Cheong, Young-Soo Shin
BACKGROUND: It is unclear whether lateral meniscal allograft transplantation (MAT) procedures lead to better clinical outcomes than medial MAT. HYPOTHESIS: The survival rates are similar between medial and lateral MAT, but the clinical outcomes of lateral MAT are better than those of medial MAT at final follow-up. STUDY DESIGN: Meta-analysis. METHODS: In this meta-analysis, we reviewed studies that assessed survival rates in patients who underwent medial or lateral MAT with more than 5 years of follow-up and that used assessments such as pain and Lysholm scores to compare postoperative scores on knee outcome scales...
June 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28584897/effects-of-juice-processing-on-oxalate-contents%C3%A2-in-carambola-juice-products
#8
Nha K Huynh, Ha V H Nguyen
Effects of processing methods including pressing, enzyme-assisted extraction, lactic acid fermentation by Lactobacillus acidophilus, and alcohol fermentation by Saccharomyces cerevisiae on total and soluble oxalate contents of carambola juices were studied. In comparison with pressing, the use of enzyme increased juice yields (15.89-17.29%), but resulted in higher total oxalate (1.60-1.73 times) and soluble oxalate contents (1.16-1.49 times). In addition, extension of enzyme incubation periods led to an increase in soluble oxalate contents in the products (p < 0...
June 6, 2017: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/28569381/lncrna-tp53tg1-participated-in-the-stress-response-under-glucose-deprivation-in-glioma
#9
Xin Chen, Yang Gao, Deheng Li, Bin Hao, Yiqun Cao
Gliomas are the most common brain tumors of the center nervous system. And long non-coding RNAs (lncRNAs) are non-protein coding transcripts, which have been considered as one type of gene expression regulator for cancer development. In this study, we investigated the role of lncRNA-TP53TG1 in response to glucose deprivation in human gliomas. The expression levels of TP53TG1 in glioma tissues and cells were analyzed by qRT-PCR. In addition, the influence of TP53TG1 on glucose metabolism related genes at the mRNA level during both high and low glucose treatment was detected by qRT-PCR...
June 1, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28544201/influence-of-highly-porous-electrospun-plga-pcl-nha-fibrous-scaffolds-on-the-differentiation-of-tooth-bud-cells-in-vitro
#10
Xinjie Cai, Sofie Ten Hoopen, Weibo Zhang, Charles Yi, Wanxun Yang, Fang Yang, John A Jansen, X Frank Walboomers, Pamela C Yelick
In this study, we investigated the use of three-dimensional electrospun poly(lactic-co-glycolic acid)/poly(ε-caprolactone) (PLGA/PCL) scaffolds seeded and cultured with postnatal dental cells, for improved dental tissue regeneration. Wet-electrospinning combined with ultrasonic treatment was studied as a method to enhance scaffold porosity and to promote cell-cell interactions. We also investigated whether nano-hydroxyapatite (nHA) incorporation could enhance dental cell differentiation. All scaffolds were seeded with human tooth pulp-derived dental mesenchymal (hDM) cells, or a combination of hDM and pig dental epithelial (pDE) cells, cultured for up to 28 days...
May 24, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28541005/a-combined-closing-wedge-distal-femoral-osteotomy-and-medial-reefing-procedure-for-recurrent-patellar-dislocation-with-genu-valgum
#11
Chong Bum Chang, Gautam M Shetty, Jong Seong Lee, Young Chan Kim, Jae Ho Kwon, Kyung Wook Nha
PURPOSE: Recurrent patellar dislocation is often associated with genu valgum. The purpose of this study was to analyze the short-term results of single-incision, closing-wedge distal femoral osteotomy (CWDFO) combined with medial reefing and lateral release for recurrent patellar instability with genu valgum. MATERIALS AND METHODS: Combined CWDFO/medial reefing/lateral release was performed on 10 knees. Clinical evaluation was based on pre- and postoperative Knee Society Score (KSS) and Kujala patellofemoral score...
July 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28539234/biodegradable-pcl-fibroin-hydroxyapatite-porous-scaffolds-prepared-by-supercritical-foaming-for-bone-regeneration
#12
Luis Diaz-Gomez, Carlos A García-González, Jiamian Wang, Fang Yang, Salvador Aznar-Cervantes, Jose Luis Cenis, Ricardo Reyes, Araceli Delgado, Carmen Évora, Angel Concheiro, Carmen Alvarez-Lorenzo
Regenerative medicine seeks advanced solutions for bone repair in the form of bioactive synthetic scaffolds by using simple and reproducible processing techniques. In this work, poly-ε-caprolactone (PCL)-based porous scaffolds with improved osteoconductive and osteoinductive properties were processed by supercritical foaming through a careful tuning of components and processing conditions. Composite scaffolds were prepared from various combinations of PCL, silk fibroin and nano-hydroxyapatite (nHA). The green and cost-effective supercritical CO2 foaming method applied rendered solid scaffolds with 67-70% porosity...
May 21, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28532091/design-and-fabrication-of-carbon-fibers-with-needle-like-nano-ha-coating-to-reinforce-granular-nano-ha-composites
#13
Xudong Wang, Xueni Zhao, Li Zhang, Wanying Wang, Jing Zhang, Fuzhen He, Jianjun Yang
Carbon fibers (CFs) with needle-like nano-hydroxyapatite (nHA) coating were first used as reinforcing materials named nHA-CFs to improve the mechanical properties of pure HA. A powder mixture containing nHA-CFs and granular nano-HA (gHA) was directly sintered by hot pressing at appropriate sintering pressure and temperature. A three-phase nHA-CFs/gHA composite was designed, fabricated, and used as an artificial bone. Results show that the bending strengths of the nHA-CFs/gHA composite are approximately 41.1% and 59...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28512712/post-translational-tubulin-modifications-in-human-astrocyte-cultures
#14
V Bleu Knight, Elba E Serrano
The cytoskeletal protein tubulin plays an integral role in the functional specialization of many cell types. In the central nervous system, post-translational modifications and the expression of specific tubulin isotypes in neurons have been analyzed in greater detail than in their astrocytic counterparts. In this study, we characterized post-translational specifications of tubulin in human astrocytes using the normal human astrocyte (NHA; Lonza) commercial cell line of fetal origin. Immunocytochemical techniques were implemented in conjunction with confocal microscopy to image class III β-tubulin (βIII-tubulin), acetylated tubulin, and polyglutamylated tubulin using fluorescent antibody probes...
May 17, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28501777/mir-140-bdnf-axis-regulates-normal-human-astrocyte-proliferation-and-lps-induced-il-6-and-tnf-%C3%AE-secretion
#15
Zhiming Tu, Yawei Li, Yuliang Dai, Lei Li, Guohua Lv, Ivan Chen, Bing Wang
Reactive astrocyte proliferation after spinal cord injury (SCI) contributes to glial scar formation that impedes axonal regeneration. The mechanisms underlying astrocyte proliferation upon injury remain partially understood. MicroRNAs (miRNAs) function as a major class of post-transcriptional gene expression regulators that participate in many biological processes. In this study, we focused on the functional role of miR-140 in normal human astrocyte (NHA) cell proliferation. Ectopic miR-140 expression significantly inhibited NHA cell viability and proliferation; miR-140 inhibition exerted the opposite function...
July 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28456121/effects-of-root-exudates-on-denitrifier-gene-abundance-community-structure-and-activity-in-a-micro-polluted-constructed-wetland
#16
Hailu Wu, Xinze Wang, Xiaojuan He, Shengbo Zhang, Rubing Liang, Jian Shen
In micro-polluted constructed wetland (CW), the low pollutant concentrations and the low COD/N ratios (chemical oxygen demand: total nitrogen in influent), make the biological treatment more difficult. It is expected that root exudates drive microbial-based transformations within plant rhizosphere. In this research, the roles of root exudates of three aquatic plants (Phragmites australis, Typha angustifolia and Cyperus alternifolius) in improving the growth of heterotrophic denitrifying bacteria were determined in a micro-polluted CW...
November 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28430344/surfactant-assisted-synthesis-of-polyvinylpyrrolidone-hydroxyapatite-composites-as-a-bone-filler
#17
Masoumeh Meskinfam Langroudi, Masoud Giahi Saravani, Azita Nouri
BACKGROUND: Different methods have been used to prepare bone-like composites from inorganic nanoparticles embedded in polymeric matrixes to obtain the properties and structures required for bone fillers. METHODS: Bone-like nano-hydroxyapatite (nHA) was synthesized using a biomimetic method, with polyvinylpyrrolidone (PVP) as template and sodium dodecyl sulfate (SDS) as surfactant. RESULTS: The results demonstrated the formation of HA composites and showed that polymer and surfactant as the polymer capsule can be properly used to control the size, shape, morphology and dispersion of HA crystals...
April 11, 2017: Journal of Applied Biomaterials & Functional Materials
https://www.readbyqxmd.com/read/28419419/the-isoprenoid-derivative-n-6-benzyladenosine-cm223-exerts-antitumor-effects-in-glioma-patient-derived-primary-cells-through-the-mevalonate-pathway
#18
Elena Ciaglia, Manuela Grimaldi, Mario Abate, Mario Scrima, Manuela Rodriquez, Chiara Laezza, Roberta Ranieri, Simona Pisanti, Pierangela Ciuffreda, Clementina Manera, Patrizia Gazzerro, Anna Maria D'Ursi, Maurizio Bifulco
BACKGROUND AND PURPOSE: N(6) -Isopentenyladenosine (i6A) is a modified nucleoside exerting in vitro and in vivo antiproliferative effects. We previously demonstrated that the actions of i6A correlate with the expression and activity of farnesyl pyrophosphate synthase (FPPS), a key enzyme involved in the mevalonate (MVA) pathway, which is aberrant in brain cancer. To develop new anti-glioma strategies, we tested related compounds exhibiting greater activity than i6A. EXPERIMENTAL APPROACH: We designed and synthesized i6A derivatives characterized by the introduction of diverse chemical moieties in the N6 position of adenosine and tested for their efficacy in U87 cells and in primary glioma cultures, derived from patients...
April 18, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28413590/effect-of-nano-hydroxyapatite-toothpaste-on-microhardness-ofartificial-carious-lesions-created-on-extracted-teeth
#19
Asghar Ebadifar, Mohammad Nomani, Sayed Ali Fatemi
Background. Many types of toothpastes contain substances that can remineralize initial enamel caries. This study aimed to assess the effect of nano-hydroxyapatite (NHA) on microhardness of artificially created carious lesions. Methods. In this in vitro study, NHA was prepared using sol-gel technique and added to the toothpaste with 7% concentration. A total of 80 extracted sound teeth were collected. The crowns were polished using 500-grit abrasive paper. The specimens were randomly coded from 1 to 80. Number 1 to 40 were assigned to group A and numbers 41 to 80 to group B...
2017: Journal of Dental Research, Dental Clinics, Dental Prospects
https://www.readbyqxmd.com/read/28407806/development-and-validation-of-classifiers-and-variable-subsets-for-predicting-nursing-home-admission
#20
Mikko Nuutinen, Riikka-Leena Leskelä, Ella Suojalehto, Anniina Tirronen, Vesa Komssi
BACKGROUND: In previous years a substantial number of studies have identified statistically important predictors of nursing home admission (NHA). However, as far as we know, the analyses have been done at the population-level. No prior research has analysed the prediction accuracy of a NHA model for individuals. METHODS: This study is an analysis of 3056 longer-term home care customers in the city of Tampere, Finland. Data were collected from the records of social and health service usage and RAI-HC (Resident Assessment Instrument - Home Care) assessment system during January 2011 and September 2015...
April 13, 2017: BMC Medical Informatics and Decision Making
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