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https://www.readbyqxmd.com/read/29785447/posterior-cortical-breakage-leads-to-posterior-tibial-slope-change-in-lateral-hinge-fracture-following-opening-wedge-high-tibial-osteotomy
#1
Sung-Sahn Lee, Kyung-Wook Nha, Dae-Hee Lee
PURPOSE: This study was designed to analyze the relationship between changes in posterior tibial slope and the absence or presence of lateral hinge fracture, diagnosed in the sagittal and axial planes, as well as the coronal plane, by computed tomography (CT) following opening wedge high tibial osteotomy (HTO). METHODS: This study involved 55 patients (55 knees) undergoing opening wedge HTO for primary medial osteoarthritis. Lateral hinge fractures were evaluated on CT scans according to the Takeuchi classification and were also classified as subtypes A, B, and C, depending on anterior, posterior, and both anterior and posterior cortical disruptions, respectively, as determined by the sagittal and axial planes of CT scans which corresponded to the fracture line visible on coronal CT scans...
May 21, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29781740/predicting-the-impact-of-pneumococcal-conjugate-vaccine-programme-options-in-vietnam
#2
Olivier Le Polain de Waroux, W John Edmunds, Kensuke Takahashi, Koya Ariyoshi, E Kim Mulholland, David Goldblatt, Yoon Hong Choi, Dang Duc Anh, Lay Myint Yoshida, Stefan Flasche
Although catch-up campaigns (CCs) at the introduction of pneumococcal conjugate vaccines (PCVs) may accelerate their impact, supply constraints may limit their benefit if the need for additional PCV doses results in introduction delay. We studied the impact of PCV13 introduction with and without CC in Nha Trang, Vietnam - a country that has not yet introduced PCV - through a dynamic transmission model. We modelled the impact on carriage and invasive pneumococcal disease (IPD) of routine vaccination (RV) only and that of RV with CCs targeting <1y olds (CC1), <2y olds (CC2) and <5y olds (CC5)...
May 21, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29780246/remineralization-potential-of-nano-hydroxyapatite-on-enamel-and-cementum-surrounding-margin-of-computer-aided-design-and-computer-aided-manufacturing-ceramic-restoration
#3
Niwut Juntavee, Apa Juntavee, Preeyarat Plongniras
Objective: This study investigates the effects of nano-hydroxyapatite (NHA) gel and Clinpro (CP) on remineralization potential of enamel and cementum at the cavosurface area of computer-aided design and computer-aided manufacturing ceramic restoration. Materials and methods: Thirty extracted human mandibular third molars were sectioned at 1 mm above and below the cemento-enamel junction to remove the cemento-enamel junction portions and replaced them with zirconia ceramic disks by bonding them to the crown and root portions with resin cement...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29780057/prevalence-and-risk-factors-of-dengue-infection-in-khanh-hoa-province-viet-nam-a-stratified-cluster-sampling-survey
#4
Vien Quang Mai, Trịnh Thị Xuan Mai, Ngo Le Minh Tam, Le Trung Nghia, Kenichi Komada, Hitoshi Murakami
BACKGROUND: Dengue is a clinically important arthropod-borne viral disease with increasing global incidence. Here we aimed to estimate the prevalence of dengue infections in Khanh Hoa Province, central Viet Nam, and to identify risk factors for infection. METHODS: We performed a stratified cluster sampling survey including residents of 3-60 years of age in Nha Trang City, Ninh Hoa District and Dien Khanh District, Khanh Hoa Province, in October 2011. Immunoglobulin G (IgG) and immunoglobulin M (IgM) against dengue were analyzed using a rapid test kit...
May 19, 2018: Journal of Epidemiology
https://www.readbyqxmd.com/read/29688749/surgical-treatment-with-closing-wedge-distal-femoral-osteotomy-for-recurrent-patellar-dislocation-with-genu-valgum
#5
Kyung Wook Nha, Yoonwon Ha, Seungmin Oh, Vivek P Nikumbha, Sae Kwang Kwon, Woo-Jin Shin, Byung Hoon Lee, Keun Bae Hong
BACKGROUND: Closing-wedge distal femoral osteotomy (CWDFO)-combined with medial reefing and lateral release, if necessary- has been used to treat recurrent patellar dislocation (RPD) with genu valgum. PURPOSE: To evaluate the clinical and radiologic outcomes of surgical treatment with CWDFO for treatment of RPD with genu valgum. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: Fourteen consecutive patients (23 knees) with RPD and genu valgum were treated with CWDFO...
April 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29687630/composite-pla-peg-nha-dexamethasone-scaffold-prepared-by-3d-printing-for-bone-regeneration
#6
Xiaoyuan Li, Yu Wang, Zigui Wang, Yanxin Qi, Linlong Li, Peibiao Zhang, Xuesi Chen, Yubin Huang
3D printing has become an essential part of bone tissue engineering and attracts great attention for the fabrication of bioactive scaffolds. Combining this rapid manufacturing technique with chemical precipitation, biodegradable 3D scaffold composed of polymer matrix (polylactic acid and polyethylene glycol), ceramics (nano hydroxyapatite), and drugs (dexamethasone (Dex)) is prepared. Results of water contact angle, differential scanning calorimeter, and mechanical tests confirm that incorporation of Dex leads to significantly improved wettability, higher crystallinity degree, and tunable degradation rates...
April 24, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29686222/circular-rna-hsa-circ-0012129-promotes-cell-proliferation-and-invasion-in-30-cases-of-human-glioma-and-human-glioma-cell-lines-u373-a172-and-shg44-by-targeting-microrna-661-mir-661
#7
Gang Xie
BACKGROUND Circular RNA (circRNA) is a stable non-coding RNA without 5'-3' polarity and without a poly-A tail, that contains response elements for microRNAs (miRNAs) such as miR-661. There have previously been few reported studies on the role of circRNAs in glioma. The aim of this study was to investigate the effects of the expression of the circRNA, hsa-circ-0012129, and miR-661 in human glioma tissue and human glioma cell lines. MATERIAL AND METHODS Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression of hsa-circ-0012129 and miR-661 in glioma tissues from 31 patients (WHO grades I-IV), compared with adjacent normal tissue, and in human glioma cell lines, U373, A172, and SHG44, compared with the normal human astrocyte cell line, NHA...
April 24, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29680415/home-antibiotics-at-discharge-for-pediatric-complicated-appendicitis-friend-or-foe
#8
Kathryn Tinsley Anderson, Marisa A Bartz-Kurycki, Akemi L Kawaguchi, Mary T Austin, Galit Holzmann-Pazgal, Lillian S Kao, Kevin P Lally, Kuojen Tsao
BACKGROUND: The role of home discharge antibiotics in children after perforated appendicitis is unclear. This study evaluates the outcomes of complicated appendicitis patients being discharged with or without home antibiotics after initial surgery and in-patient treatment. STUDY DESIGN: The 2015 and 2016 National Surgical Quality Improvement-Pediatric (NSQIP-P) database was queried for patients <18 years of age with complicated appendicitis. Home antibiotics (HA) were prescribed or not (No Home Antibiotics- NHA)...
April 19, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29679872/maize-productivity-heavy-metals-uptake-and-their-availability-in-contaminated-clay-and-sandy-alkaline-soils-as-affected-by-inorganic-and-organic-amendments
#9
Mahmoud F Seleiman, Ahmed M S Kheir
Contamination of arid and semi-arid ecosystems by toxic heavy metals is a serious concern due to its impact on growth and productivity of crop and health risk through food chain. Therefore, the aims of this investigation were to study the impact of inorganic (i.e. nano hydroxyapatite, NHA and polyacrylamide, PAM) and organic (i.e. sugar beet factory lime, SBFL and biochar, BI) soil amendments on maize productivity grown in contaminated silty clay (i.e. fluvial, lacustrine) and sandy (i.e. marine) alkaline soils...
April 15, 2018: Chemosphere
https://www.readbyqxmd.com/read/29668922/circulating-and-fecal-micrornas-as-biomarkers-for-inflammatory-bowel-diseases
#10
Katharina Schönauen, Nha Le, Ulrike von Arnim, Christian Schulz, Peter Malfertheiner, Alexander Link
Background: Assessment of the disease activity in inflammatory bowel disease (IBD) is essential for adequate treatment management and reliable noninvasive biomarkers for verification of mucosal healing are still needed. MicroRNAs (miRNAs) are differentially expressed in IBD and cancer. We aimed to evaluate the potential of circulating and fecal miRNAs as diagnostic biomarkers for IBD. Methods: In this proof-of-principle study we used 2 independent patient cohorts...
April 12, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29659670/histone-deacetylase-sirt6-inhibits-glioma-cell-growth-through-down-regulating-notch3-expression
#11
Xin Chen, Deheng Li, Yang Gao, Yiqun Cao, Bin Hao
Gliomas are the most common brain tumors of the central nervous system. In this study, we investigated the molecular mechanisms and biological function of SIRT6 in human gliomas. The expression levels of SIRT6 in glioma tissues and cells were analyzed by qRT-PCR and western blot analysis. CCK8 and clonogenicity assays were performed to detect the cell proliferation. Furthermore, the migration and invasion of glioma cells were examined by transwell assays. It was found that the expression of SIRT6 was significantly lower in human glioma tissues or cell lines compared with the normal brain tissue or NHA...
April 1, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29653367/upregulation-of-lncrna-plncrna-1-indicates-the-poor-prognosis-and-promotes-glioma-progression-by-activation-of-notch-signal-pathway
#12
Xiaolong Wang, Yungang Yan, Chunman Zhang, Wei Wei, Xin Ai, Yongbin Pang, Ying Bian
Prostate cancer-up-regulated long noncoding RNA 1(PlncRNA-1) has been demonstrated to be increased in several cancers, which plays an oncogenic role in the development of cancer. However, the exact functions and molecular mechanism of PlncRNA-1 in the tumorigenesis of glioma has not been studied. In present work, we firstly identified that PlncRNA-1 expression levels were prominently augmented in glioma patient tissues and glioma cell lines compared with adjacent noncancerous tissue and normal cells, respectively...
April 10, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29649935/polyurethane-nano-hydroxyapatite-composite-films-as-osteogenic-platforms
#13
Bailey K Barnes, Austin J Bow, Ganesh Kannarpady, Alexandru S Biris, David E Anderson, Madhu Dhar, Shawn E Bourdo
A wide variety of biomaterials are utilized in tissue engineering to generate living cells in vitro or to promote tissue growth in vivo. Regeneration of living tissue from biocompatible materials may make it possible to grow tissues ranging from bone to nerve cells. In bone regeneration, polymeric scaffolds can be enhanced by the addition of bioactive materials. To this end, this study designed several ratios of polyurethane (PU) and nano-hydroxyapatite (nHA) composites (PU-nHA ratios: 100/0, 90/10, 80/20, 70/30, 60/40 w/w)...
April 13, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29618147/where-is-the-target-point-to-prevent-cortical-hinge-fracture-in-medial-closing-wedge-distal-femoral-varus-osteotomy
#14
Kyung-Wook Nha, Yong Suk Chang, Oog-Jin Shon, Bum-Jin Shim, Jong Seong Lee, Jun Seop Song, Ji-Hoon Bae
The purpose of this study was to investigate whether the location of the hinge affects the incidence of hinge fracture during medial closing-wedge distal femoral varus osteotomy (DFVO). Twenty knees from 10 fresh-frozen human cadavers (mean age, 75 ± 17 years) were used to perform uniplanar medial closing-wedge DFVO with a 7-mm wedge. Each specimen was randomly assigned to either group A (supracondylar hinge) or group B (lateral condylar hinge). The incidence of hinge fracture and stability was compared between both groups after uniplanar medial closing-wedge DFVO...
April 4, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29609958/the-genus-vietbocap-louren%C3%A3-o-pham-2010-in-the-thien-duong-cave-vietnam-a-possible-case-of-subterranean-speciation-in-scorpions-scorpiones-pseudochactidae
#15
Wilson R Lourenço, Dinh-Sac Pham, Thi-Hang Tran, Thi-Hang Tran
Two new species of scorpion belonging to the family Pseudochactidae and to the genus Vietbocap are described based on specimens collected in the Thien Duong cave, which belongs to the Vom cave system, in the Phong Nha-Ke Bang National Park, Quang Binh Province, Vietnam. The previously described species from this cave, Vietbocap thienduongensis Lourenço & Pham, 2012 was collected in the initial section of the cave (1500 to 1800m from the cave entrance) and proved to be a true troglobitic element. The diagnosis of this species, only known from males, is completed based on females collected at 750m from the cave entrance...
March 30, 2018: Comptes Rendus Biologies
https://www.readbyqxmd.com/read/29574377/atmospheric-nitrate-export-in-streams-along-a-montane-to-urban-gradient
#16
Ilann Bourgeois, Joel Savarino, Julien Némery, Nicolas Caillon, Sarah Albertin, Franck Delbart, Didier Voisin, Jean-Christophe Clément
Nitrogen (N) emissions associated with urbanization exacerbate the atmospheric N influx to remote ecosystems - like mountains -, leading to well-documented detrimental effects on ecosystems (e.g., soil acidification, pollution of freshwaters). Here, the importance and fate of N deposition in a watershed was evaluated along a montane to urban gradient, using a multi-isotopic tracers approach (Δ17 O, δ15 N, δ18 O of nitrate, δ2 H and δ18 O of water). In this setting, the montane streams had higher proportions of atmospheric nitrate compared to urban streams, and exported more atmospheric nitrate on a yearly basis (0...
August 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29529590/reinforced-chitosan-membranes-by-microspheres-for-guided-bone-regeneration
#17
Di Huang, Lulu Niu, Jian Li, Jingjing Du, Yan Wei, Yinchun Hu, Xiaojie Lian, Weiyi Chen, Kaiqun Wang
In order to improve the osteogenic activity and mechanical strength of the guided bone regeneration (GBR) membrane for repairing bone defect, nano-hydroxyapatite/chitosan (nHA/CS) composite microspheres were prepared through in situ biomimetic method, then composite microspheres were incorporated into CS membrane. The morphologies and mechanical properties of the composite membranes were investigated through scanning electronic microscopy (SEM) and universal mechanical testing machine. The results show that the in situ biomimetic nHA/CS microspheres were embedded in CS membrane and were integrated tightly with CS matrix...
May 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29511441/a-novel-hybrid-3d-printed-titanium-scaffold-for-osteogenesis-in-a-rabbit-calvarial-defect-model
#18
Bo Yin, Bingjian Xue, Zhihong Wu, Jiguang Ma, Keming Wang
The aim of this study was to explore an innovative method to improve the osteogenic ability of porous titanium. We used gelatin (Gel) and nano-hydroxyapatite (nHA) to construct micro-scaffolds within the pores of porous titanium alloy. We compared three groups: control, Gel:nHA = 1:0, and Gel:nHA = 1:1. We assessed cell attachment, cell proliferation, and osteogenic (alkaline phosphatase [ALP] and collagen type 1 [Col-1]) and cytoskeletal (Talin) gene and protein expression in MC3T3-E1 cells. We also evaluated osteogenic abilities in a rabbit calvarial defect model...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/29510329/lc-ms-ms-method-for-the-determination-of-the-prodrug-aripiprazole-lauroxil-and-its-three-metabolites-in-plasma-and-its-application-to-in-vitro-biotransformation-and-animal-pharmacokinetic-studies
#19
Yiying Sun, Xiaoyan Lu, Yunyun Gai, Chunjie Sha, Guangyi Leng, Xiucheng Yang, Wanhui Liu
A sensitive and selective LC-MS/MS method for determination of the prodrug aripiprazole lauroxil (AL) and the three metabolites (N-hydroxymethyl aripiprazole [NHA], aripiprazole [ARP], and dehydro aripiprazole [DHA]) in plasma was developed using ARP-d8 as an internal standard. The analytes were determined on an AB Sciex Triple Quad™ 4500 system using positive ion electrospray ionization and selected multiple reaction monitoring mode. Solid phase extraction was applied for sample preparation for AL, ARP, and DHA, and protein precipitation for NHA...
April 1, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29500982/optimization-simulated-injection-molding-process-for-ultrahigh-molecular-weight-polyethylene-nanocomposite-hip-liner-using-response-surface-methodology-and-simulation-of-mechanical-behavior
#20
Behzad Shiroud Heidari, Seyed Mohammad Davachi, Amin Hedayati Moghaddam, Javad Seyfi, Iman Hejazi, Razi Sahraeian, Hamid Rashedi
In this study, injection molding process of ultrahigh molecular weight polyethylene (UHMWPE) reinforced with nano-hydroxyapatite (nHA) was simulated and optimized through minimizing the shrinkage and warpage of the hip liners as an essential part of a hip prosthesis. Fractional factorial design (FFD) was applied to the design of the experiment, modeling, and optimizing the shrinkage and warpage of UHMWPE/nHA composite liners. The Analysis of variance (ANOVA) was applied to find the importance of operative parameters and their effects...
May 2018: Journal of the Mechanical Behavior of Biomedical Materials
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