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https://www.readbyqxmd.com/read/28086775/rapid-decline-in-the-susceptibility-of-plasmodium-falciparum-to-dihydroartemisinin-piperaquine-in-the-south-of-vietnam
#1
Ngo Viet Thanh, Nguyen Thuy-Nhien, Nguyen Thi Kim Tuyen, Nguyen Thanh Tong, Nguyen Thuy Nha-Ca, Le Thanh Dong, Huynh Hong Quang, Jeremy Farrar, Guy Thwaites, Nicholas J White, Marcel Wolbers, Tran Tinh Hien
BACKGROUND: Artemisinin resistant Plasmodium falciparum has emerged in the countries of the Greater Mekong sub-region posing a serious threat to global malaria elimination efforts. The relationship of artemisinin resistance to treatment failure has been unclear. METHODS: In annual studies conducted in three malaria endemic provinces in the south of Vietnam (Binh Phuoc, Ninh Thuan and Gia Lai) between 2011 and 2015, 489 patients with uncomplicated P. falciparum malaria were enrolled in detailed clinical, parasitological and molecular therapeutic response assessments with 42 days follow up...
January 13, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28077456/revealing-nonclassicality-beyond-gaussian-states-via-a-single-marginal-distribution
#2
Jiyong Park, Yao Lu, Jaehak Lee, Yangchao Shen, Kuan Zhang, Shuaining Zhang, Muhammad Suhail Zubairy, Kihwan Kim, Hyunchul Nha
A standard method to obtain information on a quantum state is to measure marginal distributions along many different axes in phase space, which forms a basis of quantum-state tomography. We theoretically propose and experimentally demonstrate a general framework to manifest nonclassicality by observing a single marginal distribution only, which provides a unique insight into nonclassicality and a practical applicability to various quantum systems. Our approach maps the 1D marginal distribution into a factorized 2D distribution by multiplying the measured distribution or the vacuum-state distribution along an orthogonal axis...
January 11, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28056713/three-dimensional-printed-bone-scaffolds-the-role-of-nano-micro-hydroxyapatite-particles-on-the-adhesion-and-differentiation-of-human-mesenchymal-stem-cells
#3
Marco Domingos, Antonio Gloria, Jorge Coelho, Paulo Bartolo, Joaquim Ciurana
Bone tissue engineering is strongly dependent on the use of three-dimensional scaffolds that can act as templates to accommodate cells and support tissue ingrowth. Despite its wide application in tissue engineering research, polycaprolactone presents a very limited ability to induce adhesion, proliferation and osteogenic cell differentiation. To overcome some of these limitations, different calcium phosphates, such as hydroxyapatite and tricalcium phosphate, have been employed with relative success. This work investigates the influence of nano-hydroxyapatite and micro-hydroxyapatite (nHA and mHA, respectively) particles on the in vitro biomechanical performance of polycaprolactone/hydroxyapatite scaffolds...
December 1, 2016: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/28030863/real-world-clinical-practice-of-intensified-chemotherapies-for-metastatic-pancreatic-cancer-results-from-a-pan-european-questionnaire-study
#4
Nha Le, Alessio Vinci, Marvin Schober, Sebastian Krug, Muhammad A Javed, Thomas Kohlmann, Malin Sund, Albrecht Neesse, Georg Beyer
INTRODUCTION: Recently, FOLFIRINOX and gemcitabine + nab-paclitaxel have been introduced as a novel intensified chemotherapy regimen for patients with metastasized pancreatic cancer. This study aims to analyze the real-world clinical practice with FOLFIRINOX and gemcitabine + nab-paclitaxel across Europe. METHODS: Invitations to participate in an anonymous web-based questionnaire were sent via e-mail to 5,420 doctors in 19 European countries through the network of national gastroenterological, oncological, surgical and pancreatic societies as well as the European Pancreatic Club...
December 29, 2016: Digestion
https://www.readbyqxmd.com/read/28024596/laminated-electrospun-nha-phb-composite-scaffolds-mimicking-bone-extracellular-matrix-for-bone-tissue-engineering
#5
Zhuoyue Chen, Yue Song, Jing Zhang, Wei Liu, Jihong Cui, Hongmin Li, Fulin Chen
Electrospinning is an effective means to generate nano- to micro-scale polymer fibers resembling native extracellular matrix for tissue engineering. However, a major problem of electrospun materials is that limited pore size and porosity may prevent adequate cellular infiltration and tissue ingrowth. In this study, we first prepared thin layers of hydroxyapatite nanoparticle (nHA)/poly-hydroxybutyrate (PHB) via electrospinning. We then laminated the nHA/PHB thin layers to obtain a scaffold for cell seeding and bone tissue engineering...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27989347/effect-of-combined-fibular-osteotomy-on-the-pressure-of-the-tibiotalar-and-talofibular-joints-in-supramalleolar-osteotomy-of-the-ankle-a%C3%A2-cadaveric-study
#6
Gi Won Choi, Soon Hyuck Lee, Kyung Wook Nha, Sung Jae Lee, Won Hyeon Kim, Chang-Sub Uhm
We investigated the effect of combined fibular osteotomy on the pressure of the tibiotalar and talofibular joints in medial opening-wedge supramalleolar osteotomy. Three different tibial osteotomy gaps (6, 8, and 10 mm) were created in 10 cadaveric models, and the pressure in the tibiotalar and talofibular joints was measured under axial load before and after fibular osteotomy. The heel alignment angle and talar translation ratio were evaluated radiographically. An increase in osteotomy gap led to increases in hindfoot valgus (p = ...
January 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/27982185/physico-chemical-and-histomorphometric-evaluation-of-zinc-containing-hydroxyapatite-in-rabbits-calvaria
#7
Alinne Azevedo Pereira da Silva Suruagy, Adriana Terezinha Neves Novellino Alves, Suelen Cristina Sartoretto, José de Albuquerque Calasans-Maia, José Mauro Granjeiro, Mônica Diuana Calasans-Maia
The aim of this study was to characterize the physico-chemical properties and bone repair after implantation of zinc-containing nanostructured porous hydroxyapatite scaffold (nZnHA) in rabbits' calvaria. nZnHA powder containing 2% wt/wt zinc and stoichiometric nanostructured porous hydroxyapatite (nHA - control group) were shaped into disc (8 mm) and calcined at 550 °C. Two surgical defects were created in the calvaria of six rabbits (nZnHA and nHA). After 12 weeks, the animals were euthanized and the grafted area was removed, fixed in 10% formalin with 0...
October 2016: Brazilian Dental Journal
https://www.readbyqxmd.com/read/27981546/lncrna-h19-is-overexpressed-in-glioma-tissue-is-negatively-associated-with-patient-survival-and-promotes-tumor-growth-through-its-derivative-mir-675
#8
T Zhang, Y-R Wang, F Zeng, H-Y Cao, H-D Zhou, Y-J Wang
OBJECTIVE: Glioma is one of the most common and invasive tumors of the central nervous system. Long non-coding (lnc) RNAs are involved in many cancers, but their function and mechanism in glioma remain largely unknown. We wished to delineate the role of lncRNA H19 and its derivative miR-675 in this tumor. PATIENTS AND METHODS: Using qPCR, we compared expression of lncRNA H19 in 35 specimens of glioma vs control tissue, and in two glioma cell lines U251 and U87 vs Normal Human Astrocyte (NHA) cells...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27930487/influence-of-chronic-heat-acclimatization-on-occupational-thermal-strain-in-tropical-field-conditions
#9
Matt B Brearley, Ian Norton, Daryl Rush, Michael Hutton, Steve Smith, Linda Ward, Hector Fuentes
OBJECTIVE: To examine whether non-heat acclimatized (NHA) emergency responders endure greater physiological and perceptual strain than heat acclimatized (HA) counterparts in tropical field settings. METHODS: Eight HA and eight NHA men urban search and rescue personnel had physiological and perceptual responses compared during the initial 4 hours shift of a simulated disaster in tropical conditions (ambient temperature 34.0 °C, 48% relative humidity, wet bulb globe temperature [WBGT] 31...
December 2016: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27920525/fabrication-and-characterization-of-drug-loaded-nano-hydroxyapatite-polyamide-66-scaffolds-modified-with-carbon-nanotubes-and-silk-fibroin
#10
Meng-Zhu Yao, Ming-Yi Huang-Fu, Hui-Na Liu, Xia-Rong Wang, Xiaoxia Sheng, Jian-Qing Gao
Nano-hydroxyapatite/polyamide 66 (nHA/PA66) porous scaffolds were fabricated by a phase inversion method. Carbon nanotubes (CNTs) and silk fibroin (SF) were used to modify the surface of the nHA/PA66 scaffolds by freeze-drying and cross-linking. Dexamethasone was absorbed to the CNTs to promote the osteogenic differentiation of bone mesenchymal stem cells (BMSCs). The cell viability of BMSCs was investigated by changing the concentration of the CNT dispersion, and the most biocompatible scaffold was selected...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27907160/as1411-induced-growth-inhibition-of-glioma-cells-by-up-regulation-of-p53-and-down-regulation-of-bcl-2-and-akt1-via-nucleolin
#11
Ye Cheng, Gang Zhao, Siwen Zhang, Fares Nigim, Guangtong Zhou, Zhiyun Yu, Yang Song, Yong Chen, Yunqian Li
AS1411 binds nucleolin (NCL) and is the first oligodeoxynucleotide aptamer to reach phase I and II clinical trials for the treatment of several cancers. However, the mechanisms by which AS1411 targets and kills glioma cells and tissues remain unclear. Here we report that AS1411 induces cell apoptosis and cycle arrest, and inhibits cell viability by up-regulation of p53 and down-regulation of Bcl-2 and Akt1 in human glioma cells. NCL was overexpressed in both nucleus and cytoplasm in human glioma U87, U251 and SHG44 cells compared to normal human astrocytes (NHA)...
2016: PloS One
https://www.readbyqxmd.com/read/27894174/modified-iliac-crest-reconstruction-with-bone-cement-for-reduction-of-donor-site-pain-and-morbidity-after-open-wedge-high-tibial-osteotomy-a-prospective-study
#12
Jong Seong Lee, Yong Jee Park, Lih Wang, Yong Suk Chang, Gautam M Shetty, Kyung Wook Nha
Purpose: This study was to determine the efficacy of iliac crest reconstruction using bone cement in reducing pain and morbidity at the donor site in patients undergoing open wedge high tibial osteotomy (OWHTO) with tricortical iliac crest autologous graft. Materials and Methods: Thirty-three patients who underwent iliac crest reconstruction using polymethyl methacrylate (PMMA) bone cement (group A) and thirty patients who had no iliac crest reconstruction (group B) were enrolled in this study...
December 1, 2016: Knee Surgery & related Research
https://www.readbyqxmd.com/read/27885807/loading-of-bmp2-related-peptide-onto-three-dimensional-nano-hydroxyapatite-scaffolds-accelerates-mineralization-in-critical-sized-cranial-bone-defects
#13
Tingfang Sun, Kui Zhou, Man Liu, Xiaodong Guo, Yanzhen Qu, Wei Cui, ZengWu Shao, Xianglin Zhang, Shuyun Xu
Extrusion free-forming, as a rapid prototyping technique, is extensively applied in fabricating ceramic material in bone tissue engineering. To improve the osteoinductivity of nano-hydroxyapatite (nHA) scaffold fabricated by extrusion free-forming, in this study, we incorporated a new peptide (P28) and optimized the superficial microstructure after shaping by controlling the sintering temperature. P28, a novel bone morphogenic protein 2 (BMP-2)-related peptide, was designed in this study. Analysis of the structure, physicochemical properties, and release kinetics of P28 from nHA sintered at temperatures ranging from 1000 °C to 1400 °C revealed that nHA sintered at 1000 °C had higher porosity, preferable pore size, and better capacity to control P28 release than that sintered at other temperatures...
November 25, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27861760/maternal-support-of-children-s-early-numerical-concept-learning-predicts-preschool-and-first-grade-math-achievement
#14
Beth M Casey, Caitlin M Lombardi, Dana Thomson, Hoa Nha Nguyen, Melissa Paz, Cote A Theriault, Eric Dearing
The primary goal in this study was to examine maternal support of numerical concepts at 36 months as predictors of math achievement at 4½ and 6-7 years. Observational measures of mother-child interactions (n = 140) were used to examine type of support for numerical concepts. Maternal support that involved labeling the quantities of sets of objects was predictive of later child math achievement. This association was significant for preschool (d = .45) and first-grade math (d = .49), controlling for other forms of numerical support (identifying numerals, one-to-one counting) as well as potential confounding factors...
November 14, 2016: Child Development
https://www.readbyqxmd.com/read/27846918/neurology-health-advocacy-curriculum-needs-assessment-curricular-content-and-underlying-components
#15
Ahmad Rida Abuzinadah, Lara Cooke
BACKGROUND: Lack of a health advocacy curriculum and clarity are obstacles for effectively teaching neurology health advocacy (NHA) to neurology residents. Our purpose is to assess the need and develop content for a NHA curriculum and to describe its underlying components. METHODS: This is a cross-sectional study with two steps. In step one, neurologists and neurology residents at University of Calgary were surveyed about their perception of teaching NHA and asked to rank 56 neurological diseases on a Likert scale based on how well they lend themselves to teaching health advocacy...
November 16, 2016: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/27833244/nigeria-s-national-health-act-an-assessment-of-health-professionals-knowledge-and-perception
#16
Osahon Enabulele, Joan Emien Enabulele
BACKGROUND: Nigeria's National Health Act 2014 (NHA 2014) was signed into law on October 31, 2014. It provides a legal framework for the regulation, development, and management of Nigeria's Health System. This study assessed the knowledge and perception of the NHA 2014 by health professionals. MATERIALS AND METHODS: This was a descriptive, cross-sectional, questionnaire-based study conducted in December 2015, in Ota, Ogun State, Nigeria. Data entry and analysis were done using the Statistical Package for the Social Sciences version 16 (IBM SPSS, Chicago, IL, USA) statistical software, with Pearson's Chi-square, which is used to determine the associations between variables...
September 2016: Nigerian Medical Journal: Journal of the Nigeria Medical Association
https://www.readbyqxmd.com/read/27832326/silencing-of-histone-deacetylase-2-suppresses-malignancy-for-proliferation-migration-and-invasion-of-glioblastoma-cells-and-enhances-temozolomide-sensitivity
#17
Zhiqiang Zhang, Yunmin Wang, Jiehan Chen, Qijia Tan, Caijun Xie, Cong Li, Wengang Zhan, Mei Wang
Histone deacetylases (HDACs) can regulate the progression of various cancers, while their roles in glioblastoma multiforme (GBM) are not well known. Our present study investigated the expression of class I HDACs (HDAC1, 2, 3, 8) in GBM U87, A172, U251, and LN229 cells and compared their levels with that in primary normal human astrocytes (NHA) cells. It showed that HDAC2 expression is significantly up-regulated in GBM cells. Silencing of HDAC2 via its specific siRNAs can suppress the in vitro proliferation, migration, and invasion of GBM U87 and A172 cells...
November 10, 2016: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/27831601/-a-risk-based-monitoring-model-for-health-care-service-institutions-as-a-tool-to-protect-health-rights-in-peru
#18
Vicente A Benites-Zapata, Héctor A Saravia-Chong, Edward Mezones-Holguin, Allen J Aquije-Díaz, José Villegas-Ortega, Gustavo Rossel-de-Almeida, Carlos Acosta-Saal, Flor Philipps-Cuba
Objectives.: To describe the monitoring model of the Health Care Service Institutions (HCSI) of the National Health Authority (NHA) and assess the factors associated with risk-adjusted normative compliance (%RANC) within the Peruvian Health System (PHS). Materials and Methods.: We carried out a case study of the experience of the NHA in the development and implementation of a monitoring program based on the ISO 31000-2009. With HCSI as the units of analysis, we calculated the %RANC (a scorein continuous scale ranging from 0 to 100) for comprehensive monitoring (CM) and for specific evaluations made from 2013 to 2015...
July 2016: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/27790585/clinical-and-radiologic-evaluation-of-regenerative-potential-of-nha-paste-and-dbm-in-the-treatment-of-periodontal-intra-bony-defects-a-randomized-control-trial
#19
Deepti Jain, Anshul Sawhney, Bharat Gupta, Saurabh Sharma, Saurabh Juneja, Manjushree Juneja, Shruti Sharma, Neha Patil
INTRODUCTION: Previous studies have shown that Hydroxyapatite (HA) has shown good results in the treatment of intra-osseous periodontal defects. A newer variety of HA has been designed over a period of research which has nano-sized particles and is availed in a paste consistency called Nanocrystalline Hydroxyapatite paste (NHA paste). This variation in size and surface area of NHA paste can provide better results when used in intra-bony defects. AIM: The purpose of this study was to compare the clinical and radiographic outcomes obtained with usage of NHA paste to those obtained with Demineralized Bone Matrix (DBM) in the treatment of periodontal intra-bony defects...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27778142/effect-of-stocking-rate-and-supplementation-on-performance-of-dairy-cows-grazing-native-grassland-in-small-scale-systems-in-the-highlands-of-central-mexico
#20
Pedro Alan Sainz-Sánchez, Felipe López-González, Julieta Gertrudis Estrada-Flores, Carlos Galdino Martínez-García, Carlos Manuel Arriaga-Jordán
The use and management of native grassland for dairy production during the rainy season was studied on two small-scale dairy farms in the highlands of central Mexico. Two stocking rates (2 and 4 cows/ha) and two levels of supplementation with commercial concentrate (4 and 6 kg/cow/day) under grazing were given to 12 milking Holstein cows in a 4 × 4 Latin square design replicated three times in a factorial arrangement. Net herbage accumulation (NHA), sward height, chemical composition, and in vitro digestibility of organic matter were recorded for the grassland, as well as vegetation cover and herbage mass 12 weeks post experiment...
January 2017: Tropical Animal Health and Production
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