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https://www.readbyqxmd.com/read/27907160/as1411-induced-growth-inhibition-of-glioma-cells-by-up-regulation-of-p53-and-down-regulation-of-bcl-2-and-akt1-via-nucleolin
#1
Ye Cheng, Gang Zhao, Siwen Zhang, Fares Nigim, Guangtong Zhou, Zhiyun Yu, Yang Song, Yong Chen, Yunqian Li
AS1411 binds nucleolin (NCL) and is the first oligodeoxynucleotide aptamer to reach phase I and II clinical trials for the treatment of several cancers. However, the mechanisms by which AS1411 targets and kills glioma cells and tissues remain unclear. Here we report that AS1411 induces cell apoptosis and cycle arrest, and inhibits cell viability by up-regulation of p53 and down-regulation of Bcl-2 and Akt1 in human glioma cells. NCL was overexpressed in both nucleus and cytoplasm in human glioma U87, U251 and SHG44 cells compared to normal human astrocytes (NHA)...
2016: PloS One
https://www.readbyqxmd.com/read/27894174/modified-iliac-crest-reconstruction-with-bone-cement-for-reduction-of-donor-site-pain-and-morbidity-after-open-wedge-high-tibial-osteotomy-a-prospective-study
#2
Jong Seong Lee, Yong Jee Park, Lih Wang, Yong Suk Chang, Gautam M Shetty, Kyung Wook Nha
Purpose: This study was to determine the efficacy of iliac crest reconstruction using bone cement in reducing pain and morbidity at the donor site in patients undergoing open wedge high tibial osteotomy (OWHTO) with tricortical iliac crest autologous graft. Materials and Methods: Thirty-three patients who underwent iliac crest reconstruction using polymethyl methacrylate (PMMA) bone cement (group A) and thirty patients who had no iliac crest reconstruction (group B) were enrolled in this study...
December 1, 2016: Knee Surgery & related Research
https://www.readbyqxmd.com/read/27885807/loading-of-bmp2-related-peptide-onto-three-dimensional-nano-hydroxyapatite-scaffolds-accelerates-mineralization-in-critical-sized-cranial-bone-defects
#3
Tingfang Sun, Kui Zhou, Man Liu, Xiaodong Guo, Yanzhen Qu, Wei Cui, ZengWu Shao, Xianglin Zhang, Shuyun Xu
Extrusion free-forming, as a rapid prototyping technique, is extensively applied in fabricating ceramic material in bone tissue engineering. To improve the osteoinductivity of nano-hydroxyapatite (nHA) scaffold fabricated by extrusion free-forming, in this study, we incorporated a new peptide (P28) and optimized the superficial microstructure after shaping by controlling the sintering temperature. P28, a novel bone morphogenic protein 2 (BMP-2)-related peptide, was designed in this study. Analysis of the structure, physicochemical properties, and release kinetics of P28 from nHA sintered at temperatures ranging from 1000 °C to 1400 °C revealed that nHA sintered at 1000 °C had higher porosity, preferable pore size, and better capacity to control P28 release than that sintered at other temperatures...
November 25, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27861760/maternal-support-of-children-s-early-numerical-concept-learning-predicts-preschool-and-first-grade-math-achievement
#4
Beth M Casey, Caitlin M Lombardi, Dana Thomson, Hoa Nha Nguyen, Melissa Paz, Cote A Theriault, Eric Dearing
The primary goal in this study was to examine maternal support of numerical concepts at 36 months as predictors of math achievement at 4½ and 6-7 years. Observational measures of mother-child interactions (n = 140) were used to examine type of support for numerical concepts. Maternal support that involved labeling the quantities of sets of objects was predictive of later child math achievement. This association was significant for preschool (d = .45) and first-grade math (d = .49), controlling for other forms of numerical support (identifying numerals, one-to-one counting) as well as potential confounding factors...
November 14, 2016: Child Development
https://www.readbyqxmd.com/read/27846918/neurology-health-advocacy-curriculum-needs-assessment-curricular-content-and-underlying-components
#5
Ahmad Rida Abuzinadah, Lara Cooke
BACKGROUND: Lack of a health advocacy curriculum and clarity are obstacles for effectively teaching neurology health advocacy (NHA) to neurology residents. Our purpose is to assess the need and develop content for a NHA curriculum and to describe its underlying components. METHODS: This is a cross-sectional study with two steps. In step one, neurologists and neurology residents at University of Calgary were surveyed about their perception of teaching NHA and asked to rank 56 neurological diseases on a Likert scale based on how well they lend themselves to teaching health advocacy...
November 16, 2016: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/27833244/nigeria-s-national-health-act-an-assessment-of-health-professionals-knowledge-and-perception
#6
Osahon Enabulele, Joan Emien Enabulele
BACKGROUND: Nigeria's National Health Act 2014 (NHA 2014) was signed into law on October 31, 2014. It provides a legal framework for the regulation, development, and management of Nigeria's Health System. This study assessed the knowledge and perception of the NHA 2014 by health professionals. MATERIALS AND METHODS: This was a descriptive, cross-sectional, questionnaire-based study conducted in December 2015, in Ota, Ogun State, Nigeria. Data entry and analysis were done using the Statistical Package for the Social Sciences version 16 (IBM SPSS, Chicago, IL, USA) statistical software, with Pearson's Chi-square, which is used to determine the associations between variables...
September 2016: Nigerian Medical Journal: Journal of the Nigeria Medical Association
https://www.readbyqxmd.com/read/27832326/silencing-of-histone-deacetylase-2-suppresses-malignancy-for-proliferation-migration-and-invasion-of-glioblastoma-cells-and-enhances-temozolomide-sensitivity
#7
Zhiqiang Zhang, Yunmin Wang, Jiehan Chen, Qijia Tan, Caijun Xie, Cong Li, Wengang Zhan, Mei Wang
Histone deacetylases (HDACs) can regulate the progression of various cancers, while their roles in glioblastoma multiforme (GBM) are not well known. Our present study investigated the expression of class I HDACs (HDAC1, 2, 3, 8) in GBM U87, A172, U251, and LN229 cells and compared their levels with that in primary normal human astrocytes (NHA) cells. It showed that HDAC2 expression is significantly up-regulated in GBM cells. Silencing of HDAC2 via its specific siRNAs can suppress the in vitro proliferation, migration, and invasion of GBM U87 and A172 cells...
November 10, 2016: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/27831601/-a-risk-based-monitoring-model-for-health-care-service-institutions-as-a-tool-to-protect-health-rights-in-peru
#8
Vicente A Benites-Zapata, Héctor A Saravia-Chong, Edward Mezones-Holguin, Allen J Aquije-Díaz, José Villegas-Ortega, Gustavo Rossel-de-Almeida, Carlos Acosta-Saal, Flor Philipps-Cuba
Objectives.: To describe the monitoring model of the Health Care Service Institutions (HCSI) of the National Health Authority (NHA) and assess the factors associated with risk-adjusted normative compliance (%RANC) within the Peruvian Health System (PHS). Materials and Methods.: We carried out a case study of the experience of the NHA in the development and implementation of a monitoring program based on the ISO 31000-2009. With HCSI as the units of analysis, we calculated the %RANC (a scorein continuous scale ranging from 0 to 100) for comprehensive monitoring (CM) and for specific evaluations made from 2013 to 2015...
July 2016: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/27790585/clinical-and-radiologic-evaluation-of-regenerative-potential-of-nha-paste-and-dbm-in-the-treatment-of-periodontal-intra-bony-defects-a-randomized-control-trial
#9
Deepti Jain, Anshul Sawhney, Bharat Gupta, Saurabh Sharma, Saurabh Juneja, Manjushree Juneja, Shruti Sharma, Neha Patil
INTRODUCTION: Previous studies have shown that Hydroxyapatite (HA) has shown good results in the treatment of intra-osseous periodontal defects. A newer variety of HA has been designed over a period of research which has nano-sized particles and is availed in a paste consistency called Nanocrystalline Hydroxyapatite paste (NHA paste). This variation in size and surface area of NHA paste can provide better results when used in intra-bony defects. AIM: The purpose of this study was to compare the clinical and radiographic outcomes obtained with usage of NHA paste to those obtained with Demineralized Bone Matrix (DBM) in the treatment of periodontal intra-bony defects...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27778142/effect-of-stocking-rate-and-supplementation-on-performance-of-dairy-cows-grazing-native-grassland-in-small-scale-systems-in-the-highlands-of-central-mexico
#10
Pedro Alan Sainz-Sánchez, Felipe López-González, Julieta Gertrudis Estrada-Flores, Carlos Galdino Martínez-García, Carlos Manuel Arriaga-Jordán
The use and management of native grassland for dairy production during the rainy season was studied on two small-scale dairy farms in the highlands of central Mexico. Two stocking rates (2 and 4 cows/ha) and two levels of supplementation with commercial concentrate (4 and 6 kg/cow/day) under grazing were given to 12 milking Holstein cows in a 4 × 4 Latin square design replicated three times in a factorial arrangement. Net herbage accumulation (NHA), sward height, chemical composition, and in vitro digestibility of organic matter were recorded for the grassland, as well as vegetation cover and herbage mass 12 weeks post experiment...
October 25, 2016: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/27772716/uniformly-dispersed-nanohydroxapatite-reinforced-poly-%C3%AE%C2%B5-caprolactone-composite-films-for-tendon-tissue-engineering-application
#11
Shi Yun Tong, Zuyong Wang, Poon Nian Lim, Wilson Wang, Eng San Thian
Regeneration of injuries at tendon-to-bone interface (TBI) remains a challenging issue due to the complex tissue composition involving both soft tendon tissues and relatively hard bone tissues. Tissue engineering using polymeric/ceramic composites has been of great interest to generate scaffolds for tissue's healing at TBI. Herein, we presented a novel method to blend polymers and bioceramics for tendon tissue engineering application. A homogeneous composite comprising of nanohydroxyapatite (nHA) particles in poly(ε-caprolactone) (PCL) matrix was obtained using a combination of solvent and mechanical blending process...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27766838/3d-bioprinting-a-cell-laden-bone-matrix-for-breast-cancer-metastasis-study
#12
Xuan Zhou, Wei Zhu, Margaret Nowicki, Shida Miao, Haitao Cui, Benjamin Holmes, Robert I Glazer, Lijie Grace Zhang
Metastasis is one of the deadliest consequences of breast cancer, with bone being one of the primary sites of occurrence. Insufficient 3D biomimetic models currently exist to replicate this process in vitro. In this study, we developed a biomimetic bone matrix using 3D bioprinting technology to investigate the interaction between breast cancer (BrCa) cells and bone stromal cells (fetal osteoblasts and human bone marrow mesenchymal stem cells (MSCs)). A tabletop stereolithography 3D bioprinter was employed to fabricate a series of bone matrices consisting of osteoblasts or MSCs encapsulated in gelatin methacrylate (GelMA) hydrogel with nanocrystalline hydroxyapatite (nHA)...
October 28, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27707983/field-comparisons-of-the-gravid-aedes-trap-gat-and-bg-sentinel-trap-for-monitoring-aedes-albopictus-diptera-culicidae-populations-and-notes-on-indoor-gat-collections-in-vietnam
#13
Brian J Johnson, Tim Hurst, Hung Luu Quoc, Isik Unlu, Christopher Freebairn, Ary Faraji, Scott A Ritchie
We report on the use of the Gravid Aedes Trap (GAT) as a surveillance device for Aedes albopictus (Skuse) relative to the BG-Sentinel (BGS) trap in field studies conducted in Trenton, NJ, and on Hammond Island, Queensland, Australia. A parallel study conducted in Nha Trang, Vietnam, assessed the use of the GAT as an indoor surveillance device as well as the use of canola oil as a noninsecticide killing agent. In Trenton and Hammond Island, the GAT collected fewer male (0.40 ± 0.12 and 0.43 ± 0.30, respectively) and female (3...
October 5, 2016: Journal of Medical Entomology
https://www.readbyqxmd.com/read/27702520/interface-modified-polylactic-acid-starch-poly-%C3%AE%C2%B5-caprolactone-antibacterial-nanocomposite-blends-for-medical-applications
#14
Seyed Mohammad Davachi, Behzad Shiroud Heidari, Iman Hejazi, Javad Seyfi, Erfan Oliaei, Arman Farzaneh, Hamid Rashedi
In this study, an optimized interface-modified ternary blend with antibacterial activity based on polylactic acid/starch/poly ε-caprolactone (PLASCL20), mixed with nano hydroxyapatite (nHA) via melt blending. This method results in a homogeneous nanocomposite blend in which the addition of 3% nHA improves the overall properties such as hydrolytic degradation, hydrophilicity, antibacterial activity and the drug release comparing to PLASCL20. Moreover, the simultaneous use of nHA and encapsulated triclosan (LATC30) compensated the negative effect of triclosan through increasing the possible cell attachment...
January 2, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27695327/fabrication-of-gelatin-methacrylate-nanohydroxyapatite-microgel-arrays-for-periodontal-tissue-regeneration
#15
Xi Chen, Shizhu Bai, Bei Li, Huan Liu, Guofeng Wu, Sha Liu, Yimin Zhao
INTRODUCTION: Periodontitis is a chronic infectious disease and is the major cause of tooth loss and other oral health issues around the world. Periodontal tissue regeneration has therefore always been the ultimate goal of dentists and researchers. Existing fabrication methods mainly focused on a top-down tissue engineering strategy in which several drawbacks remain, including low throughput and limited diffusion properties resulting from a large sample size. Gelatin methacrylate (GelMA) is a kind of photocrosslinkable and biocompatible hydrogel, with the capacities of enabling cell encapsulation and regeneration of functional tissues...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27659081/remineralizing-effect-of-topical-novamin-and-nano-hydroxyapatite-on-caries-like-lesions-in-primary-teeth
#16
Roza Haghgoo, Motahare Ahmadvand, Sareh Moshaverinia
INTRODUCTION: NovaMin is a synthetic mineral compound composed of calcium, sodium, phosphorus, and silica. It releases crystalline hydroxyl-carbonate apatite (HCA), which structurally resembles the minerals naturally found in the teeth. Nano-hydroxyapatite (NHA) is a biocompatible compound with high affinity for tooth enamel. NHA particles morphologically resemble dental enamel apatite crystals. Considering the efficacy of remineralizing agents and the importance of conservative preventive measures, this study aimed to compare the remin-eralizing effects of NovaMin and NHA on caries-like lesions in primary teeth...
2016: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/27652269/synergistic-effect-of-mesoporous-silica-and-hydroxyapatite-in-loaded-poly-dl-lactic-co-glycolic-acid-microspheres-on-the-regeneration-of-bone-defects
#17
Shu He, Kai-Feng Lin, Jun-Jun Fan, Gang Hu, Xin Dong, Yi-Nan Zhao, Yue Song, Zhong-Shang Guo, Long Bi, Jian Liu
A microsphere composite made of poly(DL-lactic-co-glycolic acid) (PLGA), mesoporous silica nanoparticle (MSN), and nanohydroxyapatite (nHA) (PLGA-MSN/nHA) was prepared and evaluated as bone tissue engineering materials. The objective of this study was to investigate the synergistic effect of MSN/nHA on biocompatibility as well as its potential ability for bone formation. First, we found that this PLGA-MSN/nHA composite performed good characteristics on microstructure, mechanical strength, and wettability. By cell culture experiments, the adhesion and proliferation rate of the cells seeded on PLGA-MSN/nHA composite was higher than those of the controls and high levels of osteogenetic factors such as ALP and Runx-2 were detected by reverse transcriptase polymerase chain reaction...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27643535/aberrant-methylation-of-protocadherin-17-and-its-prognostic-value-in-pediatric-acute-lymphoblastic-leukemia
#18
Thanh Nha Uyen, Kazuo Sakashita, Lika'a Fasih Y Al-Kzayer, Yozo Nakazawa, Takashi Kurata, Kenichi Koike
BACKGROUND: The outcome of approximately 20% of patients with acute lymphoblastic leukemia (ALL) remains poor because of disease recurrence. We examined whether DNA methylation of cadherin superfamily genes is a useful biomarker for ALL relapse. PROCEDURE: We used Infinium Methylation 450K Arrays to assess genome-wide DNA methylation status. The methylation status of each individual gene was then determined by a combination of bisulfite restriction analysis and genome bisulfite sequencing...
September 19, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27642565/recurrent-spontaneous-pneumothoraces-and-bullous-emphysema-a-novel-mutation-causing-birt-hogg-dube-syndrome
#19
Andrew Burkett, Niamh Coffey, Eva Tomiak, Nha Voduc
Birt-Hogg-Dube syndrome (BHDS) is a rare form of classically cystic lung disease that may present with spontaneous pneumothorax. The associated skin manifestations (fibrofolliculomas) are not always present. This article describes a case of spontaneous pneumothorax secondary to bullous emphysema in an otherwise healthy gentleman caused by a novel mutation in the folliculin (FLCN) gene.
2016: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/27634657/estimating-financial-resources-for-universal-access-to-sexual-reproductive-health-care-evidence-from-two-states-in-india
#20
Sarit Kumar Rout, Jalandhar Pradhan, Sarmistha Choudhury
UNLABELLED: India has made insignificant progress towards achieving universal access to sexual and reproductive health (SRH). One of the key inputs for achieving universal access to SRH is financial resources. Given this, many international agencies including the UN are emphasising on monitoring the financial progress towards achieving SRH. OBJECTIVE: To generate evidence on spending on SRH from various sources - (government, household, international donors and NGOs) to improve the accountability of the government towards SRH goal...
October 2016: Sexual & Reproductive Healthcare: Official Journal of the Swedish Association of Midwives
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