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https://www.readbyqxmd.com/read/29154783/involvement-of-monocarboxylate-transporter-1-slc16a1-in-the-uptake-of-l-lactate-in-human-astrocytes
#1
Masaya Ideno, Masaki Kobayashi, Shotaro Sasaki, Yuya Futagi, Katsuya Narumi, Ayako Furugen, Ken Iseki
PURPOSE: Astrocytes, the most abundant glial cells in the central nervous system (CNS), help neurons survive Monocarboxylate transporters (MCTs) are reported to transport l-lactate, which is important for CNS physiology and cognitive function. However, it remains unclear which MCT isoform is functionally expressed by human astrocytes. The aim of this study was to establish the contribution of each MCT isoform to l-lactate transport in human astrocytes. METHODS: The function of l-lactate transport was studied using NHA cells as a human astrocyte model and radiolabeled l-lactate...
November 14, 2017: Life Sciences
https://www.readbyqxmd.com/read/29136531/long-term-effects-of-contrasting-tillage-on-soil-organic-carbon-nitrous-oxide-and-ammonia-emissions-in-a-mediterranean-vertisol-under-different-crop-sequences
#2
Giuseppe Badagliacca, Emilio Benítez, Gaetano Amato, Luigi Badalucco, Dario Giambalvo, Vito Armando Laudicina, Paolo Ruisi
This 2-year study aimed to verify whether the continuous application of no tillage (NT) for over 20years, in comparison with conventional tillage (CT), affects nitrous oxide (N2O) and ammonia (NH3) emissions from a Vertisol and, if so, whether such an effect varies with crop sequence (continuous wheat, WW and wheat after faba bean, FW). To shed light on the mechanisms involved in determining N-gas emissions, soil bulk density, water filled pore space (WFPS), some carbon (C) and nitrogen (N) pools, denitrifying enzyme activity (DEA), and nitrous oxide reductase gene abundance (nosZ gene) were also assessed at 0-15 and 15-30cm soil depth...
November 11, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29128121/occurrence-of-greenhouse-gases-in-the-aquifers-of-the-walloon-region-belgium
#3
Anna Jurado, Alberto V Borges, Estanislao Pujades, Vivien Hakoun, Joël Otten, Kay Knöller, Serge Brouyère
This work aims to (1) identify the most conductive conditions for the generation of greenhouses gases (GHGs) in groundwater (e.g., hydrogeological contexts and geochemical processes) and (2) evaluate the indirect emissions of GHGs from groundwater at a regional scale in Wallonia (Belgium). To this end, nitrous oxide (N2O), methane (CH4) and carbon dioxide (CO2) concentrations and the stable isotopes of nitrate (NO3(-)) and sulphate were monitored in 12 aquifers of the Walloon Region (Belgium). The concentrations of GHGs range from 0...
November 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29101803/composite-scaffolds-loaded-with-bone-mesenchymal-stem-cells-promote-the-repair-of-radial-bone-defects-in-rabbit-model
#4
Shi-Qiang Ruan, Jiang Deng, Ling Yan, Wen-Liang Huang
This study aimed to investigate the efficacy of three-dimensional scaffolds of silk fibroin/chitosan/nano-hydroxyapatite (SF/CS/nHA) and bone marrow derived mesenchymal stem cells (BMSCs) on the repair of long segmental bone defects in rabbits. BMSCs were cultured with SF/CS/nHA in vitro, and cell proliferation, alkaline phosphatase activity and Ca2+ content were examined. A 15mm segmental defect in the radius was generated in 12 New Zealand White rabbits, which were divided randomly into three groups (n=4): experimental group with SF/CS/nHA scaffold of induced BMSCs; control group with SF/CS/nHA scaffold; and blank group without any materials...
November 1, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29079090/n-loss-to-drain-flow-and-n2o-emissions-from-a-corn-soybean-rotation-with-winter-rye
#5
K Gillette, R W Malone, T C Kaspar, L Ma, T B Parkin, D B Jaynes, Q X Fang, J L Hatfield, G W Feyereisen, K C Kersebaum
Anthropogenic perturbation of the global nitrogen cycle and its effects on the environment such as hypoxia in coastal regions and increased N2O emissions is of increasing, multi-disciplinary, worldwide concern, and agricultural production is a major contributor. Only limited studies, however, have simultaneously investigated NO3(-) losses to subsurface drain flow and N2O emissions under corn-soybean production. We used the Root Zone Water Quality Model (RZWQM) to evaluate NO3(-) losses to drain flow and N2O emissions in a corn-soybean system with a winter rye cover crop (CC) in central Iowa over a nine year period...
October 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29075041/deregulated-expression-and-activity-of-farnesyl-diphosphate-synthase-fdps-in-glioblastoma
#6
Mario Abate, Chiara Laezza, Simona Pisanti, Giovanni Torelli, Vincenzo Seneca, Giuseppe Catapano, Francesco Montella, Roberta Ranieri, Maria Notarnicola, Patrizia Gazzerro, Maurizio Bifulco, Elena Ciaglia
Glioblastoma (GBM), the most aggressive brain cancer, is highly dependent on the mevalonate (MVA) pathway for the synthesis of lipid moieties critical for cell proliferation but the function and regulation of key intermediate enzymes like farnesyl-diphosphate synthase (FDPS), up to now, remained unknown. A deregulated expression and activity of FDPS was the central research idea of the present study. FDPS mRNA, protein and enzyme activity were analyzed in a cohort of stage III-IV glioma patients (N = 49) and primary derived cells...
October 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29035127/healing-potential-of-nanohydroxyapatite-gelatin-and-fibrin-platelet-glue-combination-as-tissue-engineered-scaffolds-in-radial-bone-defects-of-rats
#7
Abdolhamid Meimandi-Parizi, Ahmad Oryan, Hojjat Gholipour
Different biomaterials have been used in orthopedic surgery. Evaluation of biomaterials for bone healing promotion has been a wide area of research of the orthopedic field. Sixty critical size defects of 5 mm long were bilaterally created in the radial diaphysis of 30 rats. The animals were randomly divided into six equal groups as empty defect, autograft, nanohydroxyapatite (nHA), Gelatin (Gel)-nHA, fibrin-platelet glue (FPG)-nHA, and Gel-FPG-nHA groups (n = 10 in each group). Radiographs of each forelimb were taken postoperatively on the 1st day and then at the 28th and 56th days post injury...
October 16, 2017: Connective Tissue Research
https://www.readbyqxmd.com/read/29025652/high-activity-chitosan-nano-hydroxyapatite-zoledronic-acid-scaffolds-for-simultaneous-tumor-inhibition-bone-repair-and-infection-eradication
#8
Yao Lu, Mei Li, Lihua Li, Shuzhen Wei, Xiaoming Hu, Xiaolan Wang, Guiqiu Shan, Yu Zhang, Hong Xia, Qingshui Yin
Implanted biomaterials combined tumor inhibition and bone repair property are urgently needed to address the huge bone destruction and the high local recurrence following primary surgery in bone tumor therapy. In this work, a high-activity chitosan/nano hydroxyapatite (CS/nHA) scaffold containing zoledronic acid (CS/nHA/Zol) was prepared with a facile method. The prepared CS/nHA/Zol scaffolds exhibited excellent tumor inhibition property towards giant cell tumor of bone (GCT) in vitro through inducing cells apoptosis by up-regulating pro-apoptosis genes expression and reducing the osteoclastic activity of tumor cells by down-regulating osteoclastic genes...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28993846/-hyaluronan-as-a%C3%A2-key-for-accelerated-wound-healing-in-human-3d-full-thickness-skin-models
#9
L Rüther, L Bolke, G R Schlippe, W A Voss
BACKGROUND: Wound healing can be divided into three phases: (1) exsudation phase, (2) granulation phase, (3) regeneration phase. In particular, the epithelization phase is of great importance in order to quickly reconstitute the natural skin barrier. The aim of the present study was to determine the reepithelization kinetics of untreated and 0.5% sodium hyaluronate (NHA) treated human 3D full thickness skin models. MATERIALS AND METHODS: The test protocol consisted of topically applying 10 µl of the test substance 0...
October 9, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28976827/exploring-pressures-tissue-reperfusion-and-body-positioning-a-pilot-evaluation
#10
F Coyer, M Clark, P Slattery, P Thomas, G McNamara, C Edwards, J Ingleman, J Stephenson, K Ousey
OBJECTIVE: To assess the relationship in healthy adults and critically ill patients between: patient position, body mass index (BMI), patient body temperature, interface pressure (IP) and tissue reperfusion (TR). Also to determine the relationship in critically ill patients between: Sequential Organ Failure Assessment (SOFA) score, Braden Scale score for predicting pressure injury risk, Acute Physiology and Chronic Health Evaluation II (APACHE II) severity of disease classification score, IP and TR...
October 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28946213/regulation-of-hoxa11-as-mir-214-3p-ezh2-axis-on-the-growth-migration-and-invasion-of-glioma-cells
#11
Chenyang Xu, Tao He, Zhenjiang Li, Honglin Liu, Bingqian Ding
BACKGROUND: Glioma is one of the most common and aggressive malignant tumors in central nervous system. Recently, long non-coding RNA (lncRNA) HOXA11-AS has been reported to be an oncogenic gene in multiple cancers. However, the molecular mechanisms of HOXA11-AS involved in cancer progression of human glioma remain unknown. MATERIALS AND METHODS: The expression levels of HOXA11-AS in 45 paired primary glioma tissues and cell lines were examined by quantitative real-time PCR, and the correlation between HOXA11-AS expression and clinicopathologic characteristics of patients with glioma were analyzed...
November 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28932309/the-effect-of-three-different-biomaterials-on-proliferation-and-viability-of-human-dental-pulp-stem-cells-in-vitro-study
#12
Dalia A Mohamed, Maha I Abdelfattah, Eman H A Aboulezz
BACKGROUND: Biomaterial cytotoxicity on dental stem cells plays a critical role in managing the regeneration of dental tissue. AIM: The aim of the present study was to evaluate the effect of Nano-hydroxy apatite (NHA), Mineral trioxide aggregate (MTA), and Calcium-enriched mixture (CEM) on the proliferation, and viability of human dental pulp stem cells (hDPSCs) isolated from third molar teeth. METHODS: Cultured DPSCs were characterized and the tested biomaterials were shaped into cylinders then inserted directly on the DPSCs...
August 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28910718/water-quality-of-surface-runoff-and-lint-yield-in-cotton-under-furrow-irrigation-in-northeast-arkansas
#13
M Arlene A Adviento-Borbe, Brittany D Barnes, Oluwayinka Iseyemi, Amanda M Mann, Michele L Reba, William J Robertson, Joseph H Massey, Tina G Teague
Use of furrow irrigation in row crop production is a common practice through much of the Midsouth US and yet, nutrients can be transported off-site through surface runoff. A field study with cotton (Gossypium hirsutum, L.) was conducted to understand the impact of furrow tillage practices and nitrogen (N) fertilizer placement on characteristics of runoff water quality during the growing season. The experiment was designed as a randomized complete block design with conventional (CT) and conservation furrow tillage (FT) in combination with either urea (URN) broadcast or 32% urea ammonium nitrate (UAN) injected, each applied at 101kgNha(-1)...
February 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/28888007/nano%C3%A2-calcium-phosphate-bone-cement-based-on-si-stabilized-%C3%AE-tricalcium-phosphate-with-improved-mechanical-properties
#14
M Roozbahani, M Alehosseini, M Kharaziha, R Emadi
This study aimed to develop nano‑calcium phosphate cement (nCPC) and evaluate the effect of nanosized precursors on mechanical, physical and handling properties (injectability and setting time) as well as conversion rate of nano-reactants into nano-hydroxyapatite (nHA). In this study, while alpha tricalcium phosphate (α-TCP, 98wt%) and HA (2wt%) were applied as the powder phase, 2.5wt% NaH2PO4 solution was used as liquid phase of cement. Before nano-CPC preparation, Si-stabilized α-TCP nanopowder with particle size of 10±3...
December 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28866179/fabrication-and-in-vivo-evaluation-of-hydroxyapatite-carbon-nanotube-electrospun-fibers-for-biomedical-dental-application
#15
A S Khan, A N Hussain, L Sidra, Z Sarfraz, H Khalid, M Khan, F Manzoor, L Shahzadi, M Yar, I U Rehman
The aim was to synthesize bioactive electrospun fibers for biomedical and dental application with improved biocompatibility. In situ precipitation of nano-hydroxyapatite (nHA) was performed with various concentrations (0.5%, 1%, 2%, 3%, and 5% wt/wt) of functionalized multi-walled-carbon nanotubes (MWCNTs) by using microwave irradiation technique. The obtained composites were characterized by Fourier Transform Infrared (FTIR), X-ray Diffraction (XRD), Thermogravimetric Analysis/Differential Scanning Calorimetry (TGA/DSC), and the cylindrical discs were made for mechanical testing...
November 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28845435/histologic-and-histomorphometric-comparison-between-sintered-nanohydroxyapatite-and-anorganic-bovine-xenograft-in-maxillary-sinus-grafting-a-split-mouth-randomized-controlled-clinical-trial
#16
Claudio Stacchi, Teresa Lombardi, Francesco Oreglia, Andrea Alberghini Maltoni, Tonino Traini
The presence of vital bone after maxillary sinus augmentation is crucial to enhance the quality of bone-implant interface, ensuring predictable long-term results. The aims of this RCT with split-mouth design were the histologic and histomorphometric comparison of two different biomaterials in sinus elevation after 6 months of healing and the evaluation of the clinical outcomes of implants inserted in the augmented areas after 12 months of prosthetic loading. Twenty-eight patients (10 females, 18 males) were treated with bilateral sinus floor elevation with lateral approach...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28809613/enrolling-hiv-positive-adolescents-in-mental-health-research-a-case-study-reflecting-on-legal-and-ethical-complexities
#17
Nataly Woollett, John Peter, Lucie Cluver, Heena Brahmbhatt
BACKGROUND: Adolescents living with HIV are an emerging group in the global HIV/AIDS epidemic. Mental health in this population affects HIV care, treatment, consequential morbidity and secondary transmission. There is a paucity of research regarding these youth in South Africa (SA), partly because section 71 of the National Health Act of 2003 (NHA) requires parental or guardian's consent. OBJECTIVE: To explore legal and ethical issues related to conducting adolescent mental health research in SA...
July 28, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28806146/three-dimensional-bioprinting-of-polycaprolactone-reinforced-gene-activated-bioinks-for-bone-tissue-engineering
#18
Gráinne M Cunniffe, Tomas Gonzalez-Fernandez, Andrew Daly, Binulal N Sathy, Oju Jeon, Eben Alsberg, Daniel J Kelly
Regeneration of complex bone defects remains a significant clinical challenge. Multi-tool biofabrication has permitted the combination of various biomaterials to create multifaceted composites with tailorable mechanical properties and spatially controlled biological function. In this study we sought to use bioprinting to engineer nonviral gene activated constructs reinforced by polymeric micro-filaments. A gene activated bioink was developed using RGD-γ-irradiated alginate and nano-hydroxyapatite (nHA) complexed to plasmid DNA (pDNA)...
August 14, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28790168/microrna-211-bdnf-axis-regulates-lps-induced-proliferation-of-normal-human-astrocyte-through-pi3k-akt-pathway
#19
Kexiang Zhang, Song Wu, Zhiyue Li, Jiahui Zhou
Spinal cord injury (SCI) makes a major contribution to disability and deaths worldwide. Reactive astrogliosis, a typical feature after SCI, which undergoes varying molecular and morphological changes, is ubiquitous but poorly understood. Reactive astrogliosis contributes to glial scar formation that impedes axonal regeneration. Brain-derived neurotrophic factor (BDNF), a well-established neurotrophic factor, exerts neuroprotective and growth-promoting effects on a variety of neuronal populations after injury...
August 31, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28772618/bilayer-poly-lactic-co-glycolic-acid-nano-hydroxyapatite-membrane-with-barrier-function-and-osteogenesis-promotion-for-guided-bone-regeneration
#20
Li Fu, Zhanfeng Wang, Shujun Dong, Yan Cai, Yuxin Ni, Tianshou Zhang, Lin Wang, Yanmin Zhou
Guided bone regeneration (GBR) is one such treatment that reconstructs neo-bone tissue by using a barrier membrane to prevent the invasion of soft tissue and to create a space for guiding new bone growth into the bone defect. Herein, we report a novel functionally graded bilayer membrane (FGBM) for GBR application. To fabricate the novel membrane, the composites of poly(lactic-co-glycolic acid) and nano-hydroxyapatite were prepared by phase inversion for the dense layer and by electrospinning for another porous layer, and their corresponding properties were evaluated including surface morphology, mechanics, degradability, cell barrier function, and in vitro osteogenic bioactivity...
March 3, 2017: Materials
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