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https://www.readbyqxmd.com/read/28544201/influence-of-highly-porous-electrospun-plga-pcl-nha-fibrous-scaffolds-on-the-differentiation-of-tooth-bud-cells-in-vitro
#1
Xinjie Cai, Sofie Ten Hoopen, Weibo Zhang, Charles Yi, Wanxun Yang, Fang Yang, John A Jansen, X Frank Walboomers, Pamela C Yelick
In this study, we investigated the use of three-dimensional electrospun poly(lactic-co-glycolic acid)/poly(ε-caprolactone) (PLGA/PCL) scaffolds seeded and cultured with postnatal dental cells, for improved dental tissue regeneration. Wet-electrospinning combined with ultrasonic treatment was studied as a method to enhance scaffold porosity and to promote cell-cell interactions. We also investigated whether nano-hydroxyapatite (nHA) incorporation could enhance dental cell differentiation. All scaffolds were seeded with human tooth pulp-derived dental mesenchymal (hDM) cells, or a combination of hDM and pig dental epithelial (pDE) cells, cultured for up to 28 days...
May 24, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28541005/a-combined-closing-wedge-distal-femoral-osteotomy-and-medial-reefing-procedure-for-recurrent-patellar-dislocation-with-genu-valgum
#2
Chong Bum Chang, Gautam M Shetty, Jong Seong Lee, Young Chan Kim, Jae Ho Kwon, Kyung Wook Nha
PURPOSE: Recurrent patellar dislocation is often associated with genu valgum. The purpose of this study was to analyze the short-term results of single-incision, closing-wedge distal femoral osteotomy (CWDFO) combined with medial reefing and lateral release for recurrent patellar instability with genu valgum. MATERIALS AND METHODS: Combined CWDFO/medial reefing/lateral release was performed on 10 knees. Clinical evaluation was based on pre- and postoperative Knee Society Score (KSS) and Kujala patellofemoral score...
July 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28539234/biodegradable-pcl-fibroin-hydroxyapatite-porous-scaffolds-prepared-by-supercritical-foaming-for-bone-regeneration
#3
Luis Diaz-Gomez, Carlos A García-González, Jiamian Wang, Fang Yang, Salvador Aznar-Cervantes, Jose Luis Cenis, Ricardo Reyes, Araceli Delgado, Carmen Évora, Angel Concheiro, Carmen Alvarez-Lorenzo
Regenerative medicine seeks advanced solutions for bone repair in the form of bioactive synthetic scaffolds by using simple and reproducible processing techniques. In this work, poly-ε-caprolactone (PCL)-based porous scaffolds with improved osteoconductive and osteoinductive properties were processed by supercritical foaming through a careful tuning of components and processing conditions. Composite scaffolds were prepared from various combinations of PCL, silk fibroin and nano-hydroxyapatite (nHA). The green and cost-effective supercritical CO2 foaming method applied rendered solid scaffolds with 67-70% porosity...
May 21, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28532091/design-and-fabrication-of-carbon-fibers-with-needle-like-nano-ha-coating-to-reinforce-granular-nano-ha-composites
#4
Xudong Wang, Xueni Zhao, Li Zhang, Wanying Wang, Jing Zhang, Fuzhen He, Jianjun Yang
Carbon fibers (CFs) with needle-like nano-hydroxyapatite (nHA) coating were first used as reinforcing materials named nHA-CFs to improve the mechanical properties of pure HA. A powder mixture containing nHA-CFs and granular nano-HA (gHA) was directly sintered by hot pressing at appropriate sintering pressure and temperature. A three-phase nHA-CFs/gHA composite was designed, fabricated, and used as an artificial bone. Results show that the bending strengths of the nHA-CFs/gHA composite are approximately 41.1% and 59...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28512712/post-translational-tubulin-modifications-in-human-astrocyte-cultures
#5
V Bleu Knight, Elba E Serrano
The cytoskeletal protein tubulin plays an integral role in the functional specialization of many cell types. In the central nervous system, post-translational modifications and the expression of specific tubulin isotypes in neurons have been analyzed in greater detail than in their astrocytic counterparts. In this study, we characterized post-translational specifications of tubulin in human astrocytes using the normal human astrocyte (NHA; Lonza) commercial cell line of fetal origin. Immunocytochemical techniques were implemented in conjunction with confocal microscopy to image class III β-tubulin (βIII-tubulin), acetylated tubulin, and polyglutamylated tubulin using fluorescent antibody probes...
May 17, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28501777/mir-140-bdnf-axis-regulates-normal-human-astrocyte-proliferation-and-lps-induced-il-6-and-tnf-%C3%AE-secretion
#6
Zhiming Tu, Yawei Li, Yuliang Dai, Lei Li, Guohua Lv, Ivan Chen, Bing Wang
Reactive astrocyte proliferation after spinal cord injury (SCI) contributes to glial scar formation that impedes axonal regeneration. The mechanisms underlying astrocyte proliferation upon injury remain partially understood. MicroRNAs (miRNAs) function as a major class of post-transcriptional gene expression regulators that participate in many biological processes. In this study, we focused on the functional role of miR-140 in normal human astrocyte (NHA) cell proliferation. Ectopic miR-140 expression significantly inhibited NHA cell viability and proliferation; miR-140 inhibition exerted the opposite function...
May 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28456121/effects-of-root-exudates-on-denitrifier-gene-abundance-community-structure-and-activity-in-a-micro-polluted-constructed-wetland
#7
Hailu Wu, Xinze Wang, Xiaojuan He, Shengbo Zhang, Rubing Liang, Jian Shen
In micro-polluted constructed wetland (CW), the low pollutant concentrations and the low COD/N ratios (chemical oxygen demand: total nitrogen in influent), make the biological treatment more difficult. It is expected that root exudates drive microbial-based transformations within plant rhizosphere. In this research, the roles of root exudates of three aquatic plants (Phragmites australis, Typha angustifolia and Cyperus alternifolius) in improving the growth of heterotrophic denitrifying bacteria were determined in a micro-polluted CW...
April 26, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28430344/surfactant-assisted-synthesis-of-polyvinylpyrrolidone-hydroxyapatite-composites-as-a-bone-filler
#8
Masoumeh Meskinfam Langroudi, Masoud Giahi Saravani, Azita Nouri
BACKGROUND: Different methods have been used to prepare bone-like composites from inorganic nanoparticles embedded in polymeric matrixes to obtain the properties and structures required for bone fillers. METHODS: Bone-like nano-hydroxyapatite (nHA) was synthesized using a biomimetic method, with polyvinylpyrrolidone (PVP) as template and sodium dodecyl sulfate (SDS) as surfactant. RESULTS: The results demonstrated the formation of HA composites and showed that polymer and surfactant as the polymer capsule can be properly used to control the size, shape, morphology and dispersion of HA crystals...
April 11, 2017: Journal of Applied Biomaterials & Functional Materials
https://www.readbyqxmd.com/read/28419419/the-isoprenoid-derivative-n6-benzyladenosine-cm223-exerts-antitumor-effect-in-glioma-patient-derived-primary-cells-through-the-mevalonate-pathway
#9
Elena Ciaglia, Manuela Grimaldi, Mario Abate, Mario Scrima, Manuela Rodriquez, Chiara Laezza, Roberta Ranieri, Simona Pisanti, Pierangela Ciuffreda, Clementina Manera, Patrizia Gazzerro, Anna Maria D'Ursi, Maurizio Bifulco
BACKGROUND AND PURPOSE: N6-Isopentenyladenosine (i6A) is a modified nucleoside exerting in vitro and in vivo antiproliferative effects. We previously demonstrated that the i6A action is correlated to farnesyl pyrophosphate synthase (FPPS) expression and activity, a key enzyme involved in the mevalonate (MVA) pathway, which is found aberrant in brain cancer. To develop new anti-glioma strategies, we looked for other valuable compounds exhibiting improved activity as compared to i6A. EXPERIMENTAL APPROACH: we designed and synthesized i6A derivatives characterized by the introduction of diverse chemical moieties in the N6 position of adenosine and tested for their efficacy in U87 and primary derived patient's glioma cell model...
April 18, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28413590/effect-of-nano-hydroxyapatite-toothpaste-on-microhardness-ofartificial-carious-lesions-created-on-extracted-teeth
#10
Asghar Ebadifar, Mohammad Nomani, Sayed Ali Fatemi
Background. Many types of toothpastes contain substances that can remineralize initial enamel caries. This study aimed to assess the effect of nano-hydroxyapatite (NHA) on microhardness of artificially created carious lesions. Methods. In this in vitro study, NHA was prepared using sol-gel technique and added to the toothpaste with 7% concentration. A total of 80 extracted sound teeth were collected. The crowns were polished using 500-grit abrasive paper. The specimens were randomly coded from 1 to 80. Number 1 to 40 were assigned to group A and numbers 41 to 80 to group B...
2017: Journal of Dental Research, Dental Clinics, Dental Prospects
https://www.readbyqxmd.com/read/28407806/development-and-validation-of-classifiers-and-variable-subsets-for-predicting-nursing-home-admission
#11
Mikko Nuutinen, Riikka-Leena Leskelä, Ella Suojalehto, Anniina Tirronen, Vesa Komssi
BACKGROUND: In previous years a substantial number of studies have identified statistically important predictors of nursing home admission (NHA). However, as far as we know, the analyses have been done at the population-level. No prior research has analysed the prediction accuracy of a NHA model for individuals. METHODS: This study is an analysis of 3056 longer-term home care customers in the city of Tampere, Finland. Data were collected from the records of social and health service usage and RAI-HC (Resident Assessment Instrument - Home Care) assessment system during January 2011 and September 2015...
April 13, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28402219/modified-n-ha-pa66-scaffolds-with-chitosan-coating-for-bone-tissue-engineering-cell-stimulation-and-drug-release
#12
Qin Zou, Junfeng Li, Lulu Niu, Yi Zuo, Jidong Li, Yubao Li
The dipping-drying procedure and cross-linking method were used to make drug-loaded chitosan(CS) coating on nano-hydroxyapatite/polyamide66 (nHA/PA66) composite porous scaffold, endowing the scaffold controlled drug release functionality. The prefabricated scaffold was immersed into an aqueous drug/CS solution in a vacuum condition and then crosslinked by vanillin. The structure, porosity, composition, compressive strength, swelling ratio, drug release and cytocompatibility of the pristine and coating scaffolds were investigated...
April 12, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28401535/nano-hydroxyapatite-blasted-titanium-surface-affects-pre-osteoblast-morphology-by-modulating-critical-intracellular-pathways
#13
Fábio Bezerra, Marcel R Ferreira, Giselle N Fontes, Célio da Costa Fernandes, Denise C Andia, Nilson C Cruz, Rodrigo A da Silva, Willian F Zambuzzi
Since intracellular signalling pathways are proposed to predict the quality of cell-surface relationship, this study addressed pre-osteoblast behaviour in response to nano hydroxyapatite (HA)-blasted titanium (Ti) surface by exploring critical intracellular pathways and pre-osteoblast morphological change. Physicochemical properties were evaluated by atomic force microscopy and wettability considering water contact angle of three differently texturized Ti surfaces: Machined (Mac), Dual acid-etching (DAE) and nano hydroxyapatite-blasted (nHA)...
April 12, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28366859/degradation-behavior-and-compatibility-of-micro-nanoha-chitosan-scaffolds-with-interconnected-spherical-macropores
#14
Li Ruixin, Xu Cheng, Liu Yingjie, Li Hao, Shi Caihong, Su Weihua, An Weining, Yuan Yinghai, Qin Xiaoli, Xu Yunqiang, Zhang Xizheng, Li Hui
Hydroxyapatite/Chitosan (HA/CS) composite have significant application in biomedical especially for bone replacement. Inorganic particle shape and size of composite affect the scaffold mechanical property, biological property, and degradation. The aim of this study was to fabricate HA/CS scaffold with good pore connectivity and analyze their biological, degradation properties. Microhydroxyapatite/chitosan (mHA/CS) and nanohydroxyapatite/chitosan (nHA/CS) composite scaffolds with interconnected spherical pore architectures were fabricated...
March 31, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28366641/metazoan-nuclear-pores-provide-a-scaffold-for-poised-genes-and-mediate-induced-enhancer-promoter-contacts
#15
Pau Pascual-Garcia, Brian Debo, Jennifer R Aleman, Jessica A Talamas, Yemin Lan, Nha H Nguyen, Kyoung J Won, Maya Capelson
Nuclear pore complex components (Nups) have been implicated in transcriptional regulation, yet what regulatory steps are controlled by metazoan Nups remains unclear. We identified the presence of multiple Nups at promoters, enhancers, and insulators in the Drosophila genome. In line with this binding, we uncovered a functional role for Nup98 in mediating enhancer-promoter looping at ecdysone-inducible genes. These genes were found to be stably associated with nuclear pores before and after activation. Although changing levels of Nup98 disrupted enhancer-promoter contacts, it did not affect ongoing transcription but instead compromised subsequent transcriptional activation or transcriptional memory...
April 6, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28363788/mesenchymal-stem-cell-fate-following-non-viral-gene-transfection-strongly-depends-on-the-choice-of-delivery-vector
#16
T Gonzalez-Fernandez, B N Sathy, C Hobbs, G M Cunniffe, H O McCarthy, N J Dunne, V Nicolosi, F J O'Brien, D J Kelly
Controlling the phenotype of mesenchymal stem cells (MSCs) through the delivery of regulatory genes is a promising strategy in tissue engineering (TE). Essential to effective gene delivery is the choice of gene carrier. Non-viral delivery vectors have been extensively used in TE, however their intrinsic effects on MSC differentiation remain poorly understood. The objective of this study was to investigate the influence of three different classes of non-viral gene delivery vectors: (1) cationic polymers (polyethylenimine, PEI), (2) inorganic nanoparticles (nanohydroxyapatite, nHA) and (3) amphipathic peptides (RALA peptide) on modulating stem cell fate after reporter and therapeutic gene delivery...
March 29, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28361961/exposure-to-paternal-tobacco-smoking-increased-child-hospitalization-for-lower-respiratory-infections-but-not-for-other-diseases-in-vietnam
#17
Reiko Miyahara, Kensuke Takahashi, Nguyen Thi Hien Anh, Vu Dinh Thiem, Motoi Suzuki, Hiroshi Yoshino, Le Huu Tho, Hiroyuki Moriuchi, Sharon E Cox, Lay Myint Yoshida, Dang Duc Anh, Koya Ariyoshi, Michio Yasunami
Exposure to environmental tobacco smoke (ETS) is an important modifiable risk factor for child hospitalization, although its contribution is not well documented in countries where ETS due to maternal tobacco smoking is negligible. We conducted a birth cohort study of 1999 neonates between May 2009 and May 2010 in Nha Trang, Vietnam, to evaluate paternal tobacco smoking as a risk factor for infectious and non-infectious diseases. Hospitalizations during a 24-month observation period were identified using hospital records...
March 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28340454/pea-cultivar-and-wheat-residues-affect-carbon-nitrogen-dynamics-in-pea-triticale-intercropping-a-microcosms-approach
#18
Antonella Scalise, Valentini A Pappa, Antonio Gelsomino, Robert M Rees
The underlying mechanisms by which legume cultivars contribute to nitrous oxide (N2O) generation are poorly understood. The aim of the present study was to explore the effects of two pea cultivars (Zero4 and Nitouche) intercropped with triticale, with or without wheat (Triticum aestivum) residues incorporation, on soil C and N dynamics, on bacterial community structure and their links with N2O emissions. Monocrops and bare soil (no plant) treatments were used as an additional control in order to account for the level of mineralisation between treatments...
March 21, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28337023/reconstruction-of-large-scale-defects-with-a-novel-hybrid-scaffold-made-from-poly-l-lactic-acid-nanohydroxyapatite-alendronate-loaded-chitosan-microsphere-in-vitro-and-in-vivo-studies
#19
Hongwei Wu, Pengfei Lei, Gengyan Liu, Yu Shrike Zhang, Jingzhou Yang, Longbo Zhang, Jie Xie, Wanting Niu, Hua Liu, Jianming Ruan, Yihe Hu, Chaoyue Zhang
A chitosan-based microsphere delivery system has been fabricated for controlled release of alendronate (AL). The present study aimed to incorporate the chitosan/hydroxyapatite microspheres-loaded with AL (CH/nHA-AL) into poly(L-lactic acid)/nanohydroxyapatite (PLLA/nHA) matrix to prepare a novel microspheres-scaffold hybrid system (CM-ALs) for drug delivery and bone tissue engineering application. The characteristics of CM-ALs scaffolds containing 10% and 20% CH/nHA-AL were evaluated in vitro, including surface morphology and porosity, mechanical properties, drug release, degradation, and osteogenic differentiation...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28335799/convergent-and-sequential-synthesis-designs-implications-for-conducting-and-reporting-systematic-reviews-of-qualitative-and-quantitative-evidence
#20
Quan Nha Hong, Pierre Pluye, Mathieu Bujold, Maggy Wassef
BACKGROUND: Systematic reviews of qualitative and quantitative evidence can provide a rich understanding of complex phenomena. This type of review is increasingly popular, has been used to provide a landscape of existing knowledge, and addresses the types of questions not usually covered in reviews relying solely on either quantitative or qualitative evidence. Although several typologies of synthesis designs have been developed, none have been tested on a large sample of reviews. The aim of this review of reviews was to identify and develop a typology of synthesis designs and methods that have been used and to propose strategies for synthesizing qualitative and quantitative evidence...
March 23, 2017: Systematic Reviews
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