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https://www.readbyqxmd.com/read/29778982/efficient-co-delivery-of-neo-epitopes-using-dispersion-stable-layered-double-hydroxide-nanoparticles-for-enhanced-melanoma-immunotherapy
#1
Ling-Xiao Zhang, Xi-Xiu Xie, Dong-Qun Liu, Zhi Ping Xu, Rui-Tian Liu
Cancer immunotherapy has shown tremendous progresses in recent years for various cancers and layered double hydroxide (LDH) nanoparticles are demonstrated as effective adjuvants for protein-based vaccines. This research further shows that the colloidal stability of LDH-based vaccines significantly influences the therapeutic efficacy and LDH nanoparticles are able to adjuvant multiple tumor-associated antigen peptides to provoke strong cell-mediated immune responses for effective inhibition of cancer growth...
May 10, 2018: Biomaterials
https://www.readbyqxmd.com/read/29778782/acyclovir-lipid-nanocapsules-gel-for-oromucosal-delivery-a-preclinical-evidence-of-efficacy-in-the-chicken-pouch-membrane-model
#2
Darine Abozaid, Alyaa Ramadan, Heba Barakat, Nawal Khalafallah
The study aimed to develop a patient-friendly acyclovir gel with improved efficacy in viral mouth infections, in response to patients' need for an intraoral acyclovir product. Acyclovir was loaded in lipid nanocapsules in gel form, and formulae were evaluated for oromucosal delivery. Lipid nanocapsules were prepared by the phase inversion method. Formulae were optimized to achieve maximum acyclovir entrapment and minimum acyclovir precipitation. Colloidal properties, and pharmaceutical performance indicators were assessed...
May 17, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29777270/-rathke-cysts-craniopharyngioma-and-colloid-cysts-what-are-the-differences-between-these-pathologies
#3
REVIEW
R Eymann, M Kiefer
CLINICAL ISSUE: Headache is the most common symptom of colloid cysts, Rathke cysts, and craniopharyngioma due to their location in the midline, being extra-axial and typically presenting in the parasellar region. THERAPEUTIC PROBLEMS: Although these tumors are generally considered benign, each has its typical characteristics defined by its location and histology. These individual characteristics define whether surgery is necessary at all and if so, the preferred surgical approach and resection's totality...
May 17, 2018: Der Radiologe
https://www.readbyqxmd.com/read/29776696/single-layer-centrifugation-improves-the-quality-of-frozen-thawed-sperm-of-giant-panda-ailuropoda-melanoleuca
#4
Z G Cai, J H An, Y L Liu, S M Yie, Y Zhang, F P Li, J S Chen, X Wang, J M Morrell, R Hou
The reproductive capacity of captive giant pandas is poor and sperm cryopreservation is necessary for the reproduction and conservation of this species. Cryopreservation, however, leads to a significant decrease in sperm quality, including sperm motility, acrosome integrity and DNA integrity. In the present study, a method was developed based on colloid single layer centrifugation that could significantly improve frozen-thawed sperm quality. Two colloids were compared for post-thaw giant panda sperm preparation; the sperm samples had greater total motility (Colloid 1: 44...
May 15, 2018: Animal Reproduction Science
https://www.readbyqxmd.com/read/29776170/depletion-interaction-between-colloids-mediated-by-an-athermal-polymer-blend
#5
A I Chervanyov
We calculate the immersion energy of a colloid and the potential of the depletion interaction (DI) acting between colloids immersed in an athermal polymer blend. The developed theory has no limitations with respect to the polymer-to-colloid size ratios and polymer densities, covering, in particular, dense polymer blends. We demonstrate that in addition to the standard compressibility-induced mechanism of the DI there exists the mechanism relying on the correlations between compositional fluctuations specific to polymer blends...
March 2018: Physical Review. E
https://www.readbyqxmd.com/read/29776110/n-sma-smc-phase-transitions-probed-by-a-pair-of-elastically-bound-colloids
#6
Muhammed Rasi M, K P Zuhail, Arun Roy, Surajit Dhara
The competing effect of surface anchoring of dispersed microparticles and elasticity of nematic and cholesteric liquid crystals has been shown to stabilize a variety of topological defects. Here we study a pair of colloidal microparticles with homeotropic and planar surface anchoring across N-SmA-SmC phase transitions. We show that below the SmA-SmC phase transition the temperature dependence of interparticle separation (D) of colloids with homeotropic anchoring shows a power-law behavior; D∼(1-T/T_{AC})^{α}, with an exponent α≈0...
March 2018: Physical Review. E
https://www.readbyqxmd.com/read/29776043/reynolds-number-dependent-dynamical-transitions-on-hydrodynamic-synchronization-modes-of-externally-driven-colloids
#7
Norihiro Oyama, Kosuke Teshigawara, John Jairo Molina, Ryoichi Yamamoto, Takashi Taniguchi
The collective dynamics of externally driven N_{p}-colloidal systems (1≤N_{p}≤4) in a confined viscous fluid have been investigated using three-dimensional direct numerical simulations with fully resolved hydrodynamics. The dynamical modes of collective particle motion are studied by changing the particle Reynolds number as determined by the strength of the external driving force and the confining wall distance. For a system with N_{p}=3, we found that at a critical Reynolds number a dynamical mode transition occurs from the doublet-singlet mode to the triplet mode, which has not been reported experimentally...
March 2018: Physical Review. E
https://www.readbyqxmd.com/read/29776020/paramagnetic-colloids-chaotic-routes-to-clusters-and-molecules
#8
Hamed Abdi, Rasam Soheilian, Randall M Erb, Craig E Maloney
We present computer simulations and experiments on dilute suspensions of superparamagnetic particles subject to rotating magnetic fields. We focus on chains of four particles and their decay routes to stable structures. At low rates, the chains track the external field. At intermediate rates, the chains break up but perform a periodic (albeit complex) motion. At sufficiently high rates, the chains generally undergo chaotic motion at short times and decay to either closely packed clusters or more dispersed, colloidal molecules at long times...
March 2018: Physical Review. E
https://www.readbyqxmd.com/read/29775184/colloidal-transport-through-trap-arrays-controlled-by-active-microswimmers
#9
Wen Yang, Vyacheslav R Misko, Fabio Marchesoni, Franco Nori
We investigate the dynamics of a binary mixture consisting of active and passive colloidal particles diffusing in a two-dimensional
 array of truncated harmonic wells, or traps. We explore the possibility of using a small fraction of active particles to manipulate a much larger fraction of passive particles, for instance, to confine them in or extract them from the traps. The results of our study have potential application in biology and medical sciences, for example, to remove dead cells or undesired contaminants from biological systems by means of self-propelled nano-robots...
May 18, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29775046/solvent-assisted-surface-engineering-for-high-performance-all-inorganic-perovskite-nanocrystals-light-emitting-diodes
#10
Lin Wang, Baiquan Liu, Xin Zhao, Hilmi Volkan Demir, Haoshuang Gu, Handong Sun
All-inorganic cesium halide perovskite nanocrystals have attracted booming interests in optoelectronic applications for the sake of the readily adjustable bandgaps, high photoluminescence quantum yield, pure color emission and affordable cost. However, due to the ineluctable utilization of organic surfactants during the synthesis, the structural and optical properties of CsPbBr3 nanocrystals degrade upon transforming from colloidal solutions to solid thin films, which plagues the device operation. Here, we develop a novel solvent-assisted surface engineering strategy, producing high quality CsPbBr3 thin films for device applications...
May 18, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29773746/hybrid-molecular-colloidal-liquid-crystals
#11
Haridas Mundoor, Sungoh Park, Bohdan Senyuk, Henricus H Wensink, Ivan I Smalyukh
Order and fluidity often coexist, with examples ranging from biological membranes to liquid crystals, but the symmetry of these soft-matter systems is typically higher than that of the constituent building blocks. We dispersed micrometer-long inorganic colloidal rods in a nematic liquid crystalline fluid of molecular rods. Both types of uniaxial building blocks, while freely diffusing, interact to form an orthorhombic nematic fluid, in which like-sized rods are roughly parallel to each other and the molecular ordering direction is orthogonal to that of colloidal rods...
May 18, 2018: Science
https://www.readbyqxmd.com/read/29773240/perioperative-risk-factors-that-predict-complications-of-radial-forearm-free-flaps-in-oral-and-maxillofacial-reconstruction
#12
C Wang, G Fu, F Liu, L Liu, M Cao
The aim of the study was to find out what perioperative risk factors predicted complications in patients having reconstructions with radial forearm free flaps (RFFF). We organised a retrospective study of 169 patients (mean (range) age 54 (22-86) years, 100 of whom were female) who had oral and maxillofacial tumours resected, and reconstructed with RFFF, from January 2011-December 2016. We recorded predictive variables, subdivided into: personal and clinical (sex, age, weight, coexisting conditions, history of smoking, radiotherapy, and primary lesions); haemodynamic (perioperative concentrations of haemoglobin and albumin, blood loss, blood transfusion, urinary output (ml), and rate (ml/kg/hour), and infusion rates for crystalloids and colloids (ml/kg/hour, and volumes given intraoperatively and postoperatively for 24hours); and anaesthetic and surgical (American Society of Anesthesiologists(ASA) grade, visual analogue pain score (VAS), and duration of tourniquet and operation)...
May 14, 2018: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/29772988/combined-labeled-leukocyte-and-technicium-99-sulfur-colloid-bone-marrow-imaging-differentiating-primary-pyomyositis-pseudotumor-from-osteomyelitis-and-multiple-bone-infarcts
#13
Paul W Perdue, Allison B Spitzer, Dipal Chatterjee, Srinivas Kolla, Aditya V Maheshwari
A 53 year old-female patient with lupus had undergone a cephalo-medullary nailing for a femur shaft fracture 30 years ago. This was complicated by osteomyelitis, requiring multiple debridement procedures and hardware removal. Recently, she developed a painful soft tissue mass in the same region, which was ultimately diagnosed as pyomyositis. Because of chronic bone changes due to her past history, traditional imaging could not differentiate between osteomyelitis infarction and pseudotumor. A combined indium-labeled leukocyte scan with a technetium-99 sulfur colloid marrow scan ruled out osteomyelitis and guided proper treatment without osseous debridement and thus prevented unnecessary cross-contamination of the bone...
2018: Journal of Long-term Effects of Medical Implants
https://www.readbyqxmd.com/read/29772775/ph-responsive-mercaptoundecanoic-acid-functionalized-gold-nanoparticles-and-applications-in-catalysis
#14
Siyam M Ansar, Saptarshi Chakraborty, Christopher L Kitchens
Mercaptoundecanoic acid (MUA) functionalized gold nanoparticles (AuNP-MUA) were synthesized and demonstrated to possess pH-triggered aggregation and re-dispersion, as well as the capability of phase transfer between aqueous and organic phases in response to changes in pH. The pH of aggregation for AuNP-MUA is consistent with the pKa of MUA (pH ~4) in solution, while AuNP-MUA phase transition between aqueous and organic phases occurs at pH ~9. The ion pair formation between the amine group in octadecylamine (ODA), the carboxylate group in MUA, and the hydrophobic alkyl chain of ODA facilitates the phase transfer of AuNP-MUA into an organic medium...
May 17, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29772591/-monitoring-and-modern-hemodynamic-concepts-in-cardiac-anesthesia
#15
Matthias Heringlake, Christian Schmidt, Sebastian Brandt
Patients undergoing cardiac surgery are growing older, present with more comorbidities, and are frequently scheduled for more complex and prolonged surgical procedures. Routine application of neurological as well as extended hemodynamic monitoring combined with goal-directed perioperative hemodynamic optimization, targeting optimization of systemic and cerebral oxygen balance, show promise to reduce postoperative complications and to improve mortality in this high risk population. Expert recommendations suggest to avoid synthetic colloids for fluid optimization...
May 2018: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/29772424/enhanced-hexavalent-chromium-removal-performance-and-stabilization-by-magnetic-iron-nanoparticles-assisted-biochar-in-aqueous-solution-mechanisms-and-application-potential
#16
Shishu Zhu, Xiaochen Huang, Dawei Wang, Li Wang, Fang Ma
The superiority of the nanoscale zero valent iron (nZVI) assisted biochar (BC) composites compared to traditional nZVI and its application feasibility are still unclear. This study aimed to provide valuable information for practical application. Firstly, the Fe/BC mass ratio of 2:1 during the preparation of nZVI-BC was proved obtaining the complete Cr6+ removal. Then, results revealed that the initial pH value tuned Cr6+ removal performance via varying existing Cr6+ species, surface charge, and chemical states of iron nanoparticles (NPs)...
May 9, 2018: Chemosphere
https://www.readbyqxmd.com/read/29772289/nose-to-brain-drug-delivery-an-update-on-clinical-challenges-and-progress-towards-approval-of-anti-alzheimer-drugs
#17
REVIEW
Mukta Agrawal, Swarnlata Saraf, Shailendra Saraf, Sophia G Antimisiaris, Mahavir Chougule, Sunday A Shoyele, Amit Alexander
According to the Alzheimer Association Report (2017), Alzheimer's disease (AD) is the 6th primary cause of death in the USA, which affects nearly 5.5 million people. In the year 2017 itself, the cost of AD treatment in the USA has been reported to rise to $259 billion. This statistic shows the severity of the disease in the USA which is very much similar across the globe. On the other hand, the treatment remains limited to a few conventional oral medications (approved by FDA). These are mainly acting superficially from mild to the moderate AD...
May 14, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29772184/tuning-interfacial-properties-and-processes-by-controlling-the-rheology-and-structure-of-pnipam-particles-at-air-water-interfaces
#18
Armando Maestro, Daniel William Jones, Carmen S de Rojas Sanchez, Eduardo Guzmán, Michael H G Duits, Pietro Cicuta
In this work, by combining controlled experiments on single interfaces with measurements on solitary bubbles and liquid foams, we show that Poly N-Isopropyl Acrylamide (PNIPAM) microgels assembled at air/water interfaces exhibit a solid to liquid transition changing the temperature, and that this is associated with the change in the interfacial microstructure of the PNIPAM particles around their volume phase transition temperature VPTT. We show that the solid behaves as a soft 2D colloidal glass, and that the existence of this solid/liquid transition offers an ideal platform for tuning the permeability of air bubbles covered by PNIPAM and to control macroscopic foam properties such as drainage, stability and foamability...
May 17, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29771126/magnesium-nanoparticle-plasmonics
#19
John Biggins, Sadegh Yazdi, Emilie Ringe
Nanoparticles of some metals (Cu/Ag/Au) sustain oscillations of their electron cloud called localized surface plasmon resonances (LSPRs). These resonances can occur at optical frequencies and be driven by light, generating enhanced electric fields and spectacular photon scattering. However, current plasmonic metals are rare, expensive, and have a limited resonant frequency range. Recently, much attention has been focused on earth-abundant Al, but Al nanoparticles cannot resonate in the IR. The earth-abundant Mg nanoparticles reported here surmount this limitation...
May 17, 2018: Nano Letters
https://www.readbyqxmd.com/read/29770423/large-scale-patterning-of-living-colloids-for-dynamic-studies-of-neutrophil-microbe-interactions
#20
Jae Jung Kim, Eduardo Reátegui, Alex Hopke, Fatemeh Jalali, Maedeh Roushan, Patrick S Doyle, Daniel Irimia
Neutrophils are the first white blood cells to respond to microbes and to limit their invasion of the body. However, the growth of the microbes into colonies often challenges the neutrophils ability to contain them. To study the interactions between neutrophils and microbial colonies, we designed an assay for arranging microbes in clusters of controlled size (i.e. living colloids). The patterned microbes in the living colloid are mechanically trapped inside the wells and fully accessible to neutrophils. Using the assay, we studied the interactions between human neutrophils and Candida albicans and Staphylococcus aureus, two common human pathogens...
May 17, 2018: Lab on a Chip
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