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https://www.readbyqxmd.com/read/28231697/the-fecal-microbiota-composition-of-boar-duroc-yorkshire-landrace-and-hampshire-pigs
#1
Yingping Xiao, Kaifeng Li, Yun Xiang, Weidong Zhou, Guohong Gui, Hua Yang
To investigate the effect of host genetics on gut microbial diversity, we performed a structural survey of the fecal microbiota of four purebred boar pig lines: Duroc, Landrace, Hampshire and Yorkshire. The V3-V4 regions of the 16S rRNA genes were amplified and sequenced. A total of 783 OTUs were shared by all breeds, whereas other OTUs were breed-specific. Firmicutes and Bacteroidetes dominated the majority of the fecal microbiota; Clostridia, Bacilli and Bacteroidia were the major classes. Nine predominant genera were observed in all breeds and eight of them can produce short-chain fatty acids (SCFAs)...
February 23, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28231685/unmet-psychosocial-needs-in-adolescents-with-inflammatory-bowel-disease
#2
(no author information available yet)
BACKGROUND: Inflammatory bowel diseases (IBD) are severe medical conditions with adverse impact on the quality of life of both children and their caregivers. IBD are associated with many limitations in personal and interpersonal functioning, and it also restricts the patients' ability to use the full potential (extent) of their capabilities. With the progress and humanization in society, the issue of patients' needs became an important topic; however, the psychosocial functioning and quality of life of adolescents suffering from IBD and their caregivers have been understudied...
October 24, 2016: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28231682/unmet-needs-of-the-patients-with-obsessive-compulsive-disorder
#3
(no author information available yet)
BACKGROUND: Obsessive compulsive disorder (OCD) is a disabling mental disorder with the chronic and difficult course. The disorder is accompanied by numerous limitations in personal and interpersonal functioning. OCD decreases the quality of life and the chance to maintain relationships and professional status. The patients with OCD often experience a severe disabling course of the disorder. Even the individuals, who follow treatment advice, are often still highly symptomatic. In the last decade, the concept of the needs has been assessed as an extent of the traditional outcome evaluation in order to focus on the identification of the specific needs of the patients and their relatives, improve the patients´ overall mental condition and quality of life, and also to increase the treatment effectiveness of the mental disorders...
October 24, 2016: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28231639/cell-cycle-rna-regulons-coordinating-early-lymphocyte-development
#4
REVIEW
Alison Galloway, Martin Turner
Lymphocytes undergo dynamic changes in gene expression as they develop from progenitor cells lacking antigen receptors, to mature cells that are prepared to mount immune responses. While transcription factors have established roles in lymphocyte development, they act in concert with post-transcriptional and post-translational regulators to determine the proteome. Furthermore, the post-transcriptional regulation of RNA regulons consisting of mRNAs whose protein products act cooperatively allows RNA binding proteins to exert their effects at multiple points in a pathway...
February 23, 2017: Wiley Interdisciplinary Reviews. RNA
https://www.readbyqxmd.com/read/28231575/individual-biomarkers-using-molecular-personalized-medicine-approaches
#5
Hans P Zenner
Molecular personalized medicine tries to generate individual predictive biomarkers to assist doctors in their decision making. These are thought to improve the efficacy and lower the toxicity of a treatment. The molecular basis of the desired high-precision prediction is modern "omex" technologies providing high-throughput bioanalytical methods. These include genomics and epigenomics, transcriptomics, proteomics, metabolomics, microbiomics, imaging, and functional analyses. In most cases, producing big data also requires a complex biomathematical analysis...
February 24, 2017: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/28231333/molecular-mechanisms-of-cooperative-binding-of-transcription-factors-runx1-cbf%C3%AE-ets1-on-the-tcr%C3%AE-gene-enhancer
#6
Kota Kasahara, Masaaki Shiina, Ikuo Fukuda, Kazuhiro Ogata, Haruki Nakamura
Ets1 is an essential transcription factor (TF) for several important physiological processes, including cell proliferation and differentiation. Its recognition of the enhancer region of the TCRα gene is enhanced by the cooperative binding of the Runx1-CBFβ heterodimer, with the cancelation of phosphorylation-dependent autoinhibition. The detailed mechanism of this interesting cooperativity between Ets1 and the Runx1-CBFβ heterodimer is still largely unclear. Here, we investigated the molecular mechanisms of this cooperativity, by using molecular dynamics simulations...
2017: PloS One
https://www.readbyqxmd.com/read/28231296/cooperation-decision-time-and-culture-online-experiments-with-american-and-indian-participants
#7
Akihiro Nishi, Nicholas A Christakis, David G Rand
Two separate bodies of work have examined whether culture affects cooperation in economic games and whether cooperative or non-cooperative decisions occur more quickly. Here, we connect this work by exploring the relationship between decision time and cooperation in American versus Indian subjects. We use a series of dynamic social network experiments in which subjects play a repeated public goods game: 80 sessions for a total of 1,462 subjects (1,059 from the United States, 337 from India, and 66 from other countries) making 13,560 decisions...
2017: PloS One
https://www.readbyqxmd.com/read/28230923/predicting-phenotype-from-genotype-improving-accuracy-through-more-robust-experimental-and-computational-modeling
#8
Jonathan Gallion, Amanda Koire, Panagiotis Katsonis, Anne-Marie Schoenegge, Michel Bouvier, Olivier Lichtarge
Computational prediction yields efficient and scalable initial assessments of how variants of unknown significance (VUS) may affect human health. However, when discrepancies between these predictions and direct experimental measurements of functional impact arise, inaccurate computational predictions are frequently assumed as the source. Here we present a methodological analysis indicating that shortcomings in both computational and biological data can contribute to these disagreements. We demonstrate that incomplete assaying of multifunctional proteins can affect the strength of correlations between prediction and experiments; a variant's full impact on function is better quantified by considering multiple assays that probe an ensemble of protein functions...
February 23, 2017: Human Mutation
https://www.readbyqxmd.com/read/28230888/pd-cu-cooperative-catalysis-an-efficient-synthesis-of-3-isoindazolyl-allenes-via-cross-coupling-of-2-alkynyl-azobenzenes-and-terminal-alkynes
#9
Chuan Zhu, Chao Feng, Motoki Yamane
An efficient synthesis of (3-isoindazolyl)allenes from 2-alkynyl azobenzenes and terminal alkynes via cooperative Pd(PPh3)2Cl2/CuI-catalyzed cross-coupling has been developed. By making use of this approach, (3-isoindazolyl)allenes with various substituents can be synthesized in good to excellent yields. A rapid synthesis of biologically active indazolo[2,3-a]quinoline was also achieved using this method as the key step.
February 23, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28230784/the-effects-of-moderate-whole-grain-consumption-on-fasting-glucose-and-lipids-gastrointestinal-symptoms-and-microbiota
#10
Danielle N Cooper, Mary E Kable, Maria L Marco, Angela De Leon, Bret Rust, Julita E Baker, William Horn, Dustin Burnett, Nancy L Keim
This study was designed to determine if providing wheat, corn, and rice as whole (WG) or refined grains (RG) under free-living conditions will change parameters of health over a six-week intervention in healthy, habitual non-WG consumers. Measurements of body composition, fecal microbiota, fasting blood glucose, total cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), and triglycerides were made at baseline and post intervention. Subjects were given adequate servings of either WG or RG products based on their caloric need and asked to keep records of grain consumption, bowel movements, and GI symptoms weekly...
February 21, 2017: Nutrients
https://www.readbyqxmd.com/read/28230433/a-wealth-of-information-to-apply-to-lymphoedema-management
#11
Garry Cooper
Garry Cooper, Lecturer in Adult Nursing and Lymphoedema, Birmingham City University, considers how increasing knowledge in the field needs to be translated into effective, patient-focused services.
February 23, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28230099/pairing-mechanism-in-the-ferromagnetic-superconductor-ucoge
#12
Beilun Wu, Gaël Bastien, Mathieu Taupin, Carley Paulsen, Ludovic Howald, Dai Aoki, Jean-Pascal Brison
Superconductivity is a unique manifestation of quantum mechanics on a macroscopic scale, and one of the rare examples of many-body phenomena that can be explained by predictive, quantitative theories. The superconducting ground state is described as a condensate of Cooper pairs, and a major challenge has been to understand which mechanisms could lead to a bound state between two electrons, despite the large Coulomb repulsion. An even bigger challenge is to identify experimentally this pairing mechanism, notably in unconventional superconductors dominated by strong electronic correlations, like in high-Tc cuprates, iron pnictides or heavy-fermion compounds...
February 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28230053/ricin-uses-arginine-235-as-an-anchor-residue-to-bind-to-p-proteins-of-the-ribosomal-stalk
#13
Yijun Zhou, Xiao-Ping Li, Brian Y Chen, Nilgun E Tumer
Ricin toxin A chain (RTA) binds to stalk P-proteins to reach the α-sarcin/ricin loop (SRL) where it cleaves a conserved adenine. Arginine residues at the RTA/RTB interface are involved in this interaction. To investigate the individual contribution of each arginine, we generated single, double and triple arginine mutations in RTA. The R235A mutation reduced toxicity and depurination activity more than any other single arginine mutation in yeast. Further reduction in toxicity, depurination activity and ribosome binding was observed when R235A was combined with a mutation in a nearby arginine...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28230014/nimotuzumab-treatment-and-outcome-analysis-in-patients-with-leptomeningeal-metastasis-from-nonsmall-cell-lung-cancer
#14
Yanfang Ju, Jinliang Wang, Shengjie Sun, Shunchang Jiao
OBJECTIVE: Leptomeningeal metastasis (LM) leades a devastating consequence in patients with nonsmall cell lung cancer(NSCLC). Treatment is very limited for patients with LM. We introduced to use nimotuzumab (also known as h-R3) combined with methotrexate for treating LM in NSCLC patients. PATIENTS AND METHODS: In the present report, twenty patients with LM of NSCLC were included, and the clinicopathology information and outcomes after treatment were analyzed. RESULTS: All the twenty patients with LM were lung adenocarcinoma...
December 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28229805/cognitive-behaviour-therapy-for-health-anxiety-a-systematic-review-and-meta-analysis
#15
Kate Cooper, James D Gregory, Ian Walker, Sinead Lambe, Paul M Salkovskis
BACKGROUND: Health anxiety (HA), or hypochondriasis, is a psychological problem characterized by a preoccupation with the belief that one is physically unwell. A 2007 Cochrane review (Thomson and Page, 2007) found cognitive behavioural therapy (CBT) to be an effective intervention for individuals with HA. Similar findings were reported in a recent meta-analysis (Olatunji et al., 2014), which did not employ a systematic search strategy. The current review aimed to investigate the efficacy of CBT for HA, and to update the existing reviews...
March 2017: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/28229598/dipicolylamine-functionalized-polyfluorene-based-gel-with-lower-critical-solution-temperature-preparation-characterization-and-application
#16
Chunlan Xiang, Hao Wan, Mingjing Zhu, Yijing Chen, Juan Peng, Gang Zhou
A thermoresponsive fluorescent polymer gel with lower critical solution temperature (LCST) phase transition has been prepared by cooperating conjugated fluorene homopolymer poly(2,7-(9,9-di(8-di(2-picolyl)aminooctyl))fluorene) (PPAOF) and small organic dye sulforhodamine B (SRB) or its sodium salt (SRB-Na). The sol-gel phase transition originates from the electrostatic interactions between the protonated pyridyl/amino groups in PPAOF and the sulfonic groups in the organic dye molecules, as revealed by FTIR, variable-temperature 1H NMR spectroscopies, and cyclic voltammetry measurements...
February 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28229526/cooperative-effects-in-chemistry-collaborative-research-center-sfb-858-in-m%C3%A3-nster
#17
EDITORIAL
Ludger Tebben, Armido Studer
Cooperative effects are found in various research areas in chemistry, many of which are currently explored within the Collaborative Research Center SFB 858 in Münster. This Editorial gives some insights into the field and an overview of the history of the Center and those who have contributed to the development of this fascinating multidisciplinary research area.
February 23, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28229364/molecular-subtyping-in-diffuse-large-b-cell-lymphoma-closer-to-an-approach-of-precision-therapy
#18
REVIEW
Reem Karmali, Leo I Gordon
It has become clear that there is immense biological heterogeneity in diffuse large B cell lymphoma (DLBCL). Developing technology has allowed better characterization of patient subsets at a molecular level, allowing for a link of phenotype and clinical outcomes to oncogenic mechanisms and biologic signatures. Cell of origin and double hit status are able to identify aggressive subsets, with molecular profiling allowing for a clearer understanding of biologic pathways that contribute to cellular resistance to conventional treatment in these subsets...
February 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/28229342/the-prevalence-and-types-of-strabismus-and-average-of-stereopsis-in-japanese-adults
#19
Toshiaki Goseki, Hitoshi Ishikawa
PURPOSE: Few studies report the prevalence and types of strabismus, or average of stereopsis in Japanese adults. We performed ophthalmological evaluation including motility and stereopsis during medical examinations at cooperative companies. METHODS: We studies 1214 volunteers. The average age was 41.2 ± 12.6 (range 20-86) years. Examinations were carried out using their customary eyewear, evaluating alternate prism cover test (APCT), and Titmus stereo test (TST)...
February 22, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28229282/clinical-studies-in-hematologic-microtransplantation
#20
REVIEW
Kevin A David, Dennis Cooper, Roger Strair
The anti-tumor effects of allogeneic hematopoietic stem cell transplantation depend upon engraftment of donor cells followed by a graft-versus-tumor (GVT) effect. However, pre-clinical and clinical studies have established that under certain circumstances, anti-tumor responses can occur despite the absence of high levels of durable donor cell engraftment. Tumor response with little or no donor engraftment has been termed "microtransplantation." It has been hard to define conditions leading to tumor responses without donor cell persistence in humans because the degree of engraftment depends very heavily upon many patient-specific factors, including immune status and degree of prior therapy...
February 22, 2017: Current Hematologic Malignancy Reports
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