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https://www.readbyqxmd.com/read/29908202/post-translational-protein-deimination-in-cod-gadus-morhua-l-ontogeny-novel-roles-in-tissue-remodelling-and-mucosal-immune-defences
#1
Bergljót Magnadóttir, Polly Hayes, Mariya Hristova, Birkir Þór Bragason, Anthony P Nicholas, Alister W Dodds, Sigríður Guðmundsdóttir, Sigrun Lange
Peptidylarginine deiminases (PADs) are calcium dependent enzymes with physiological and pathophysiological roles conserved throughout phylogeny. PADs promote post-translational deimination of protein arginine to citrulline, altering the structure and function of target proteins. Deiminated proteins were detected in the early developmental stages of cod from 11 days post fertilisation to 70 days post hatching. Deiminated proteins were present in mucosal surfaces and in liver, pancreas, spleen, gut, muscle, brain and eye during early cod larval development...
June 13, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29907783/protective-effect-of-hydroxysafflor-yellow-a-against-acute-kidney-injury-via-the-tlr4-nf-%C3%AE%C2%BAb-signaling-pathway
#2
Juan Bai, Jinyi Zhao, Dongxiao Cui, Fan Wang, Ying Song, Lianghua Cheng, Kai Gao, Jin Wang, Long Li, Shujun Li, Yanyan Jia, Aidong Wen
This study aimed to evaluate the protective effect of hydroxysafflor yellow A (HSYA) on ischemia/reperfusion (I/R)-induced acute kidney injury via the TLR4/NF-κB pathway, both in vitro and in vivo. Rats were subjected to removal of the right kidney and I/R injury to the left kidney. Rats subjected to renal I/R injury were treated with HSYA at 0.5 h prior to I/R injury. Renal function, histopathological analysis, and cells apoptosis were measured in vivo. In vitro, proximal renal tubular cells (HK-2) were subjected to hypoxia/reoxygenation (H/R)...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907458/taci-deletion-protects-against-progressive-murine-lupus-nephritis-induced-by-baff-overexpression
#3
Tanvi Arkatkar, Holly M Jacobs, Samuel W Du, Quan-Zhen Li, Kelly L Hudkins, Charles E Alpers, David J Rawlings, Shaun W Jackson
B cells are known to promote the pathogenesis of systemic lupus erythematosus (SLE) via the production of pathogenic anti-nuclear antibodies. However, the signals required for autoreactive B cell activation and the immune mechanisms whereby B cells impact lupus nephritis pathology remain poorly understood. The B cell survival cytokine B cell activating factor of the TNF Family (BAFF) has been implicated in the pathogenesis of SLE and lupus nephritis in both animal models and human clinical studies. Although the BAFF receptor has been predicted to be the primary BAFF family receptor responsible for BAFF-driven humoral autoimmunity, in the current study we identify a critical role for signals downstream of Transmembrane Activator and CAML Interactor (TACI) in BAFF-dependent lupus nephritis...
June 12, 2018: Kidney International
https://www.readbyqxmd.com/read/29907126/nf-%C3%AE%C2%BAb-signaling-and-its-relevance-to-the-treatment-of-mantle-cell-lymphoma
#4
REVIEW
Swathi Balaji, Makhdum Ahmed, Elizabeth Lorence, Fangfang Yan, Krystle Nomie, Michael Wang
Mantle cell lymphoma is an aggressive subtype of non-Hodgkin B cell lymphoma that is characterized by a poor prognosis determined by Ki67 and Mantle Cell International Prognostic Index scores, but it is becoming increasingly treatable. The majority of patients, especially if young, achieve a progression-free survival of at least 5 years. Mantle cell lymphoma can initially be treated with an anti-CD20 antibody in combination with a chemotherapy backbone, such as VR-CAP (the anti-CD20 monoclonal antibody rituximab administered with cyclophosphamide, doxorubicin, and prednisone) or R-CHOP (the anti-CD20 monoclonal antibody rituximab administered with cyclophosphamide, doxorubicin, vincristine, and prednisone)...
June 15, 2018: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/29906494/dihydronortanshinone-a-natural-product-alleviates-lps-induced-inflammatory-response-through-nf-%C3%AE%C2%BAb-mitochondrial-ros-and-mapk-pathways
#5
Xiaxia Wu, Hongwei Gao, Ying Hou, Jie Yu, Wen Sun, Ying Wang, Xiaoyan Chen, Yulin Feng, Qiong-Ming Xu, Xiuping Chen
Inflammation is considered to be the common pathophysiological basis for a series of diseases. Documented data showed the anti-inflammatory effects of Salvia miltiorrhiza Bunge (Danshen), a traditional herb. The pharmacological activities of dihydronortanshinone (DNT), a tanshinone isolated from Danshen, remain unknown. In this study, the anti-inflammatory effects and underlying mechanisms of DNT were investigated with a lipopolysaccharide (LPS)-induced RAW264.7 macrophage model. DNT significantly suppressed LPS-induced inflammatory mediators such as nitrite oxide (NO), tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), inducible nitric oxide synthase (iNOS)...
June 12, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29905411/anti-inflammatory-and-antioxidant-effects-of-mesenchymal-and-hematopoietic-stem-cells-in-a-rheumatoid-arthritis-rat-model
#6
Hanan Abdelmawgoud, Asmaa Saleh
BACKGROUND: Mesenchymal stem cells (MSCs) are of increased importance because of their capacity to counteract inflammation and suppress host immune responses. OBJECTIVES: The aim of the study was to compare the effectiveness of MSCs and hematopoietic stem cells (HSCs) in the treatment of rheumatoid arthritis (RA). MATERIAL AND METHODS: Paw swelling was assessed by measuring the thickness of the hind paws using a caliper. Cytokines - interleukin (IL)-6, tumor necrosis factor-alpha (TNF-α), transforming growth factor-beta (TGF-β), and IL-10 - and rheumatoid factor (RF) were measured using enzyme-linked immunosorbent assay (ELISA) kits...
June 15, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29904904/ilixadencel-an-allogeneic-cell-based-anticancer-immune-primer-for-intratumoral-administration
#7
Alex Karlsson-Parra, Juliana Kovacka, Emilia Heimann, Margareth Jorvid, Sijme Zeilemaker, Sharon Longhurst, Peter Suenaert
Intratumoral administration of an immune primer is a therapeutic vaccine strategy aimed to trigger dendritic cell (DC)-mediated cross-presentation of cell-associated tumor antigens to cytotoxic CD8+ T cells without the need for tumor antigen characterization. The prevailing view is that these cross-presenting DCs have to be directly activated by pathogen-associated molecular patterns (PAMPS), including Toll-like receptor ligands or live microbial agents like oncolytic viruses. Emerging data are however challenging this view, indicating that the cross-presenting machinery in DCs is suboptimally activated by direct PAMP recognition, and that endogenous inflammatory factors are the main drivers of DC-mediated cross-presentation within the tumor...
June 14, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29904116/neutrophil-tlr4-and-pkr-are-targets-of-breast-cancer-cell-glycosaminoglycans-and-effectors-of-glycosaminoglycan-induced-april-secretion
#8
Uilst Bat-Erdene, Eric Quan, Kelvin Chan, Brianna-Marie Lee, Wejdan Matook, Ki-Young Lee, Jesusa L Rosales
A proliferation-inducing ligand (APRIL), which induces survival and migration signals and tumor growth, is commonly observed in breast cancer tissues but is not often expressed in breast cancer cells themselves. Here, we examined whether breast cancer cells induce APRIL secretion from neutrophils, which are frequently recruited into the breast tumor microenvironment. We found that breast cancer cells do stimulate neutrophils to secrete APRIL through their glycosaminoglycans. Breast cancer cells depleted of heparan sulfate or chondroitin sulfate glycosaminoglycans lose their ability to induce APRIL secretion from neutrophils, and heparan sulfate and chondroitin sulfate can induce secretion that is comparable to that of breast cancer cell-induced secretion...
June 15, 2018: Oncogenesis
https://www.readbyqxmd.com/read/29904087/damage-associated-molecular-pattern-recognition-is-required-for-induction-of-retinal-neuroprotective-pathways-in-a-sex-dependent-manner
#9
Marcus J Hooper, Jiangang Wang, Robert Browning, John D Ash
Retinal degeneration is a common cause of irreversible blindness and is caused by the death of retinal light-sensitive neurons called photoreceptors. At the onset of degeneration, stressed photoreceptors cause retinal glial cells to secrete neuroprotective factors that slow the pace of degeneration. Leukemia inhibitory factor (LIF) is one such factor that is required for endogenous neuroprotection. Photoreceptors are known to release signals of cellular stress, called damage-associated molecular patterns (DAMPs) early in degeneration, and we hypothesized that receptors for DAMPs or pattern recognition receptors (PRRs) play a key role in the induction of LIF and neuroprotective stress responses in retinal glial cells...
June 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29902933/a-nanoparticle-based-approach-to-improve-the-outcome-of-cancer-active-immunotherapy-with-lipopolysaccharides
#10
Maryam A Shetab Boushehri, Mona M A Abdel-Mottaleb, Arnaud Béduneau, Yann Pellequer, Alf Lamprecht
This study sought to develop a simple nanoparticle-based approach to enhance the efficiency and tolerability of lipopolysaccharide (LPS), a potent ligand of Toll-like Receptor 4 (TLR4), for immunotherapy in cancer. Despite holding promise within this context, the strong pro-inflammatory properties of LPS also account for its low tolerability given localized and systemic side effects, which restrict the administrable dosage. Herein, we investigated the effect of LPS decoration as a surface-active molecule on a polymeric matrix upon its efficiency and tolerability...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29902710/protective-effects-of-ginsenoside-rg1-against-lipopolysaccharide-d-galactosamine-induced-acute-liver-injury-in-mice-through-inhibiting-toll-like-receptor-4-signaling-pathway
#11
Chenqing Ning, Xiaoguang Gao, Changyuan Wang, Xiaokui Huo, Zhihao Liu, Huijun Sun, Xiaobo Yang, Pengyuan Sun, Xiaodong Ma, Qiang Meng, Kexin Liu
Acute liver injury (ALI) is a dramatic liver disease characterized by large areas of inflammation in the liver. This study aimed to investigate the protective effects of ginsenoside Rg1 (Rg1), a biologically active component in Panax ginseng, on lipopolysaccharide/d-galactosamine (LPS/D-GalN)-induced ALI in mice, and meanwhile explore the molecular mechanism in vivo and in vitro. Mice were pretreated with Rg1 for three days prior to LPS (40 μg/kg)/D-GalN (700 mg/kg) administration. The results showed that Rg1 improved the survival rate and reduced the liver to body weight ratios in mice...
June 11, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29902355/synbiotic-effects-of-the-dietary-fiber-long-chain-inulin-and-probiotic-lactobacillus-acidophilus-w37-can-be-caused-by-direct-synergistic-stimulation-of-immune-toll-like-receptors-and-dendritic-cells
#12
Alexia F P Lépine, Paul de Vos
SCOPE: Synbiotic effects of dietary fibers and lactobacilli are usually explained by synergistic modulation of gut-microbiota. New insight however has demonstrated that both dietary fibers and lactobacilli can directly stimulate immune cells and benefit consumer-immunity. Here we investigated synergistic effects of immune-active long-chain inulin (lcITF) and L. acidophilus W37 (LaW37) on dendritic cells (DCs). METHODS AND RESULTS: Effects of lcITF and LaW37 alone or combined were studied on Toll-like receptor (TLRs) signaling and cytokine secretion by DCs in the presence and absence of media of intestinal epithelial cell (IEC) exposed to the ingredients...
June 14, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29902230/immune-response-to-recombinant-burkholderia-pseudomallei-flic
#13
Sirikamon Koosakulnirand, Phornpun Phokrai, Kemajittra Jenjaroen, Rosemary A Roberts, Pongsak Utaisincharoen, Susanna J Dunachie, Paul J Brett, Mary N Burtnick, Narisara Chantratita
Burkholderia pseudomallei is a flagellated Gram-negative bacterium which is the causative agent of melioidosis. The disease poses a major public health problem in tropical regions and diabetes is a major risk factor. The high mortality rate of melioidosis is associated with severe sepsis which involves the overwhelming production of pro-inflammatory cytokines. Bacterial flagellar protein (flagellin) activates Toll-like receptor 5 (TLR5)-mediated innate immune signaling pathways and induces adaptive immune response...
2018: PloS One
https://www.readbyqxmd.com/read/29902192/presentation-matters-impact-of-association-of-amphiphilic-lps-with-serum-carrier-proteins-on-innate-immune-signaling
#14
Loreen R Stromberg, Heather M Mendez, Jessica Z Kubicek-Sutherland, Steven W Graves, Nicolas W Hengartner, Harshini Mukundan
Recognition of Pathogen-associated Molecular Patterns (PAMPs) by Toll-like receptors is central to innate immunity. Many bacterial PAMPs such as lipopolysaccharide (LPS) and lipoteichoic acid have amphiphilic properties. The hydrophobicity of amphiphilic PAMPs contributes to increasing entropy and causes these molecules to self-aggregate or bind host carrier proteins in aqueous physiological environments. The goal of this work was to determine how innate immune signaling is impacted by physical presentation and association of amphiphilic PAMPs with serum carrier proteins, using LPS as an example molecule...
2018: PloS One
https://www.readbyqxmd.com/read/29901385/integration-of-a-superparamagnetic-scaffold-and-magnetic-field-to-enhance-the-wound-healing-phenotype-of-fibroblasts
#15
Suisui Hao, Yu Zhang, Jie Meng, Jian Liu, Tao Wen, Ning Gu, Haiyan Xu
Most of the existing scaffolds for guiding tissue regeneration do not provide direct mechanical stimulation to the cells grown on them. In this work, we used nanofibrous superparamagnetic scaffolds with applied magnetic fields to build a "dynamic" scaffold platform and investigated the modulating effects of this platform on the phenotypes of fibroblasts. The results of enzyme-linked immunosorbent and transwell assays indicated that fibroblasts cultivated in this platform secreted significantly higher type I collagen, vascular endothelial growth factor A, and transforming growth factor-β1 and did so in a time-dependent manner...
June 14, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29901280/role-of-toll-like-receptor-9-signaling-on-activation-of-nasal-polyp-derived-fibroblasts-and-its-association-with-nasal-polypogenesis
#16
Soo Kyoung Park, Soung Yong Jin, Sun Hee Yeon, Sung Bok Lee, Jun Xu, Young Hoon Yoon, Ki Sang Rha, Yong Min Kim
BACKGROUND: Nasal polyposis is characterized by persistent inflammation and remodeling in sinonasal mucosa. Toll-like receptor 9 (TLR9) is a DNA receptor of the innate immune system that plays a pivotal role in fibrosis and inflammatory responses. The aim of this study is to explore the expression, activity, and potential pathogenic role of TLR9 signaling in tissue remodeling in nasal polyp-derived fibroblasts (NPDFs). METHODS: Fibrotic and inflammatory responses elicited by type A CpG oligonucleotides were examined in the NPDFs by a combination of real-time quantitative polymerase chain reaction, Western blot analysis, enzyme-linked immunosorbent assay, and immunofluorescence staining...
June 14, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29901170/overexpression-of-mir-140-5p-inhibits-lipopolysaccharide-induced-human-intervertebral-disc-inflammation-and-degeneration-by-downregulating-toll-like-receptor-4
#17
Qiang Zhang, Yiping Weng, Yuqing Jiang, Shujie Zhao, Dong Zhou, Nanwei Xu
Toll-like receptor 4 (TLR4) families are receptors for ligands that initiate extracellular or intracellular signaling, such as lipopolysaccharides (LPS). It has been reported that TLR4 activation resulted in the upregulation of a coordinated set of proinflammatory mediators and inhibition of matrix expression in the intervertebral disc (IVD). miR-140-5p (miR-140) is reported to participate in cellular anti-inflammatory processes and target TLR4. In the present study, we investigated the relationship between TLR4 and miR-140 in IVD degeneration...
June 12, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29901164/curcumin-inhibits-liver-cancer-by-inhibiting-damp-molecule-hsp70-and-tlr4-signaling
#18
Biqiong Ren, Shudi Luo, Xuefei Tian, Zhichao Jiang, Guoying Zou, Fei Xu, Tieqiu Yin, Yiran Huang, Junlong Liu
Curcumin has been revealed to inhibit liver cancer, however, no studies have reported that the mechanism of curcumin's action on liver cancer is related to damage-associated molecular pattern (DAMP) molecules heat shock protein 70 (HSP70) and the toll-like receptor 4 (TLR4) signaling. This study aimed to investigate whether the activation of TLR4 signaling by HSP70 could be inhibited by curcumin, thus investigating the possible mechanism of curcumin in the inhibition of liver cancer. Western blotting was used to evaluate the expression of the HSP70 and TLR4 in HepG2 cells and ELISA was used to detect the concentration of HSP70 in cell culture medium...
June 11, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29901105/the-roles-of-the-tlr-nf%C3%A2-%C3%AE%C2%BAb-signaling-pathway-in-the-mutual-interactions-between-the-lung-and-the-large-intestine
#19
Wen Fu, Jing Zhao, Xinglong Liu, Yongxiang Gao, Chuan Zheng
The 'exterior-interior relationship between the lung and the large intestine' is a classical basic theory in Traditional Chinese Medicine. The present study aimed to investigate the roles of the toll like receptor/nuclear factor‑κB (TLR/NF‑κB) signaling pathway in the mutual interactions between the lung and the large intestine. A rat model of allergic asthma complicated with intestinal flora disorder was established by oral administration of Candida albicans and intraperitoneal injection with ovalbumin...
May 31, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29901087/microrna%C3%A2-155-targets-myosin-light-chain-kinase-to-inhibit-the-migration-of-human-bone-marrow%C3%A2-derived-mesenchymal-stem-cells
#20
Xingbing Wang, Xu Ye, Jingjuan Ji, Jian Wang, Bo Xu, Qian Zhang, Jing Ming, Xin Liu
Toll‑like receptors (TLRs) are expressed in human bone marrow‑derived mesenchymal stromal cells (BM‑MSCs). The activation of TLRs is important in the proliferation, differ-entiation, migration and hematopoiesis‑supporting functions of BM‑MSCs. MicroRNAs (miRNAs) are involved in various biological functions by mediating mRNA degradation or inhibiting the translation of target genes. Our previous study confirmed that TLRs regulate the migration ability of BM‑MSCs. It was also identified that multiple miRNAs were regulated by TLRs...
June 5, 2018: International Journal of Molecular Medicine
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