keyword
MENU ▼
Read by QxMD icon Read
search

Toll—like receptor

keyword
https://www.readbyqxmd.com/read/29045935/emodinol-ameliorates-urate-nephropathy-by-regulating-renal-organic-ion-transporters-and-inhibiting-immune-inflammatory-responses-in-rats
#1
Hui Wu, Mengze Zhou, Guo Lu, Zhonglin Yang, Hui Ji, Qinghua Hu
Emodinol, 1β, 3β, 23-trihydroxyolean-12-en-28-acid, as the main active ingredient firstly extracted from the rhizomes of Elaeagus pungens by our Research Group, was identified with apparent uricosuric and nephroprotective effects in hyperuricemia mice in our previous study. This study aimed to investigate the renal protective effect of emodinol in urate nephropathy rats. Rats were orally administrated by combined adenine and ethambutol to induce urate nephropathy. Emodinol at various doses were administered intragastrically to urate nephropathy rats daily...
October 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29043065/cns-cell-type-localization-and-lps-response-of-tlr-signaling-pathways
#2
Gizelle M McCarthy, Courtney R Bridges, Yuri A Blednov, R Adron Harris
Background: Innate immune signaling in the brain has emerged as a contributor to many central nervous system (CNS) pathologies, including mood disorders, neurodegenerative disorders, neurodevelopmental disorders, and addiction. Toll-like receptors (TLRs), a key component of the innate immune response, are particularly implicated in neuroimmune dysfunction. However, most of our understanding about TLR signaling comes from the peripheral immune response, and it is becoming clear that the CNS immune response is unique...
2017: F1000Research
https://www.readbyqxmd.com/read/29042988/toll-like-receptor-2-and-dectin-1-function-as-promising-biomarker-for-aspergillus-fumigatus-infection
#3
Peng-Peng Zhang, Xiao-Feng Xin, Xiao-Yong Xu, Li-Ping Fang, Jie Wu, Yi Shi
In recent years, along with the wide application of organ transplantation and immunosuppressive agents, as well as the abuse of broad spectrum antibiotics, the incidence of invasive fungal infections has been increasing gradually. The present study aimed to identify novel biomarkers in cells infected with Aspergillus fumigatus. Human umbilical vein endothelial cells (HUVECs) were infected with Aspergillus fumigatus and then harvested at different time-points (0, 1, 2, 4 and 6 h). The expression Toll-like receptor 2 (TLR2) and dectin-1 expression were examined using flow cytometry and western blotting, and fluorescence-based microscopy was used to evaluate their distribution...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042860/toll-like-receptor-8-is-a-major-sensor-of-group-b-streptococcus-but-not-escherichia-coli-in-human-primary-monocytes-and-macrophages
#4
Birgitta Ehrnström, Kai Sandvold Beckwith, Mariia Yurchenko, Siv Helen Moen, June Frengen Kojen, Germana Lentini, Giuseppe Teti, Jan Kristian Damås, Terje Espevik, Jørgen Stenvik
TLR8 is the major endosomal sensor of degraded RNA in human monocytes and macrophages. It has been implicated in the sensing of viruses and more recently also bacteria. We previously identified a TLR8-IFN regulatory factor 5 (IRF5) signaling pathway that mediates IFNβ and interleukin-12 (IL-12) induction by Staphylococcus aureus and is antagonized by TLR2. The relative importance of TLR8 for the sensing of various bacterial species is however still unclear. We here compared the role of TLR8 and IRF5 for the sensing of Group B Streptococcus (GBS), S...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29042502/lipopolysaccharide-from-crypt-specific-core-microbiota-modulates-the-colonic-epithelial-proliferation-to-differentiation-balance
#5
Tomoaki Naito, Céline Mulet, Cristina De Castro, Antonio Molinaro, Azadeh Saffarian, Giulia Nigro, Marion Bérard, Mélanie Clerc, Amy B Pedersen, Philippe J Sansonetti, Thierry Pédron
We identified a crypt-specific core microbiota (CSCM) dominated by strictly aerobic, nonfermentative bacteria in murine cecal and proximal colonic (PC) crypts and hypothesized that, among its possible functions, it may affect epithelial regeneration. In the present work, we isolated representative CSCM strains using selective media based upon our initial 16S rRNA-based molecular identification (i.e., Acinetobacter, Delftia, and Stenotrophomonas). Their tropism for the crypt was confirmed, and their influence on epithelial regeneration was demonstrated in vivo by monocolonization of germfree mice...
October 17, 2017: MBio
https://www.readbyqxmd.com/read/29042497/a-single-dual-function-enzyme-controls-the-production-of-inflammatory-nod-agonist-peptidoglycan-fragments-by-neisseria-gonorrhoeae
#6
Jonathan D Lenz, Kathleen T Hackett, Joseph P Dillard
Neisseria gonorrhoeae gonococcus (GC) is a Gram-negative betaproteobacterium and causative agent of the sexually transmitted infection gonorrhea. During growth, GC releases lipooligosaccharide (LOS) and peptidoglycan (PG) fragments, which contribute significantly to the inflammatory damage observed during human infection. In ascending infection of human Fallopian tubes, inflammation leads to increased risk of ectopic pregnancy, pelvic inflammatory disease, and sterility. Of the PG fragments released by GC, most are disaccharide peptide monomers, and of those, 80% have tripeptide stems despite the observation that tetrapeptide stems make up 80% of the assembled cell wall...
October 17, 2017: MBio
https://www.readbyqxmd.com/read/29042009/identification-of-new-cpg-oligodeoxynucleotide-motifs-that-induce-expression-of-interleukin-1%C3%AE-and-nitric-oxide-in-avian-macrophages
#7
Astia Sanjaya, Jacob R Elder, Devendra H Shah
Unmethylated CpG motifs are known to stimulate mammalian toll-like receptor-9 expressing cells such as macrophages. However, the magnitude of immune-stimulation by CpG-motif can be sequence- and host-specific, implying the importance of identifying new immune-stimulatory motifs. This study aimed to determine the frequency distribution of 256 unique hexamers CpG-motifs in the Salmonella genome and to characterize their immune-stimulatory activity in avian host. We synthesized 256 CpG oligodeoxynucleotides (CpG-ODNs) each containing triplicates of a unique hexamer CpG-motif and tested their ability to induce expression of pro-inflammatory cytokine IL-1β in avian macrophages using q-RT PCR in four rounds of screening assays...
October 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29041928/the-tlr3-ticam-1-signal-constitutively-controls-spontaneous-polyposis-through-suppression-of-c-myc-in-apc-min-mice
#8
Junya Ono, Hiroaki Shime, Hiromi Takaki, Ken Takashima, Kenji Funami, Sumito Yoshida, Yohei Takeda, Misako Matsumoto, Masanori Kasahara, Tsukasa Seya
BACKGROUND: Intestinal tumorigenesis is promoted by myeloid differentiation primary response gene 88 (MyD88) activation in response to the components of microbiota in Apc (Min/+) mice. Microbiota also contains double-stranded RNA (dsRNA), a ligand for TLR3, which activates the toll-like receptor adaptor molecule 1 (TICAM-1, also known as TRIF) pathway. METHODS: We established Apc (Min/+) Ticam1 (-/-) mice and their survival was compared to survival of Apc (Min/+) Myd88 (-/-) and wild-type (WT) mice...
October 17, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/29041775/lychee-litchi-chinensis-sonn-pulp-phenolic-extract-provides-protection-against-alcoholic-liver-injury-in-mice-by-alleviating-intestinal-microbiota-dysbiosis-intestinal-barrier-dysfunction-and-liver-inflammation
#9
Juan Xiao, Ruifen Zhang, Qiuyun Zhou, Lei Liu, Fei Huang, Yuanyuan Deng, Yongxuan Ma, Zhencheng Wei, Xiaojun Tang, Mingwei Zhang
Liver injury is the most common consequence of alcohol abuse, which is promoted by the inflammatory response triggered by gut-derived endotoxins produced as a consequence of intestinal microbiota dysbiosis and barrier dysfunction. The aim of this study was to investigate whether modulation of intestinal microbiota and barrier function, and liver inflammation contributes to the hepatoprotective effect of lychee pulp phenolic extract (LPPE) in alcohol-fed mice. Mice were treated with an ethanol-containing liquid diet alone or in combination with LPPE for 8 weeks...
October 18, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29040945/quercetin-protects-mouse-liver-against-triptolide-induced-hepatic-injury-by-restoring-th17-treg-balance-through-tim-3-and-tlr4-myd88-nf-%C3%AE%C2%BAb-pathway
#10
Cai-Bing Wei, Kun Tao, Rong Jiang, Lian-Di Zhou, Qi-Hui Zhang, Chun-Su Yuan
Triptolide (TP) is a diterpene triepoxide with various biological activities, but its clinical applications have been limited by potential hepatotoxicity, which can be attributed to T helper 17 (Th17)/T regulatory (Treg) cell imbalance. Quercetin (QE), a natural flavonoid, has been reported to have many benefits and medicinal properties, including hepatoprotective activity against TP-induced liver injury. However, the hepatoprotection mechanisms have not been clarified. The present study was designed to explore the protective effect and the mechanism of QE against TP-induced liver injury...
October 14, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29039542/propofol-regulates-the-expression-of-tlr4-through-mir%C3%A2-21-in-human-umbilical-vein-endothelial-cells
#11
Ling Ma, Yue Yang, Xuechen Sun, Meiling Jiang, Yang Ma, Xilun Yang, Zhiwei Guo
Propofol (2,6-diisopropylphenol) is one of the most commonly used intravenous anesthetics. Anesthetics can regulate the inflammatory process; however, the mechanism remains to be fully elucidated. The present study aimed to investigate whether and how propofol affects the inflammatory reaction in human umbilical vein endothelial cells (HUVECs). The expression levels of Toll‑like receptor 4 (TLR4) and cluster of differentiation 14 (CD14) were determined in HUVECs treated with propofol and lipopolysaccharide (LPS) using western blot and reverse transcription‑quantitative polymerase chain reaction analyses...
October 11, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29039510/homocysteine%C3%A2-induced-oxidative-stress-through-tlr4-nf%C3%A2-%C3%AE%C2%BAb-dnmt1%C3%A2-mediated-lox%C3%A2-1-dna-methylation-in-endothelial-cells
#12
Sheng-Chao Ma, Yin-Ju Hao, Yun Jiao, Yan-Hua Wang, Ling-Bo Xu, Cai-Yan Mao, Xiao-Ling Yang, An-Ning Yang, Jue Tian, Ming-Hao Zhang, Shao-Ju Jin, Hua Xu, Yi-Deng Jiang, Hui-Ping Zhang
Atherosclerosis (AS) is a progressive disease of multifactorial origin, which occurs in response to endothelial injury. Increased homocysteine (Hcy) is considered a major cause of endothelial dysfunction, oxidative stress and DNA methylation; however, the mechanisms remain to be fully elucidated. The aim of the present study was to investigate whether Hcy causes injury to endothelial cells (ECs) by the effect of lectin‑like oxidized‑low density lipoprotein receptor‑1 (LOX‑1) DNA methylation through toll‑like receptor 4(TLR4)/nuclear factor (NF)‑κB/DNA methyltransferase (DNMT)1...
October 10, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29039483/dihydromyricetin-protects-against-lipopolysaccharide%C3%A2-induced-cardiomyocyte-injury-through-the-toll%C3%A2-like-receptor%C3%A2-4-nuclear-factor%C3%A2-%C3%AE%C2%BAb-pathway
#13
Meng-Qiao Zhou, Ling Shao, Jing Wu, Na Peng, Lu-Ping Jin, Guo-Zhen Wei, Wei Cheng, Chang-Jin Deng
Dihydromyricetin (DHM) is a bioactive flavonoid compound extracted from the stems and leaves of Ampelopsis grossedentata. Previous studies have indicated that DHM has antioxidation and antitumor capabilities, while the effect of DHM on lipopolysaccharide (LPS)‑induced cardiomyocyte injury has not been clarified. Therefore, the aim of the present study was to investigate the effect of DHM on LPS‑induced cardiomyocyte injury. In the present study, cardiomyocytes were randomized to the control (PBS), LPS and DHM + LPS groups...
October 9, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29039449/crosstalk-between-tlr2-and-sphk1-in-microglia-in-the-cerebral-ischemia-reperfusion-induced-inflammatory-response
#14
Wei Sun, Zhaoming Ding, Shengjie Xu, Zhiqiang Su, Hulun Li
Stroke is associated with high morbidity and mortality, and much remains unknown about the injury-related mechanisms that occur following reperfusion. This study aimed to explore the roles of Toll-like receptor 2 (TLR2) and sphingosine kinase 1 (Sphk1) in microglial cells in inflammatory responses induced by cerebral ischemia/reperfusion (I/R). For this purpose, C57BL/6 mice were randomly divided into 4 groups as follows: the sham-operated group, the I/R group, the I/R group treated with TLR2 antibody, and the I/R group treated with N,N-dimethylsphingosine...
September 29, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29039447/paralemmin-3-contributes-to-lipopolysaccharide-induced-inflammatory-response-and-is-involved-in-lipopolysaccharide-toll-like-receptor-4-signaling-in-alveolar-macrophages
#15
Xu-Xin Chen, Lu Tang, Yu-Mei Fu, Yi Wang, Zhi-Hai Han, Ji-Guang Meng
Alveolar macrophages (AMs) are the first line of defense against foreign stimulation in alveoli, and they participate in inflammatory responses during acute lung injury (ALI). Previous studies indicated that paralemmin-3 (PALM3) expression is induced by lipopolysaccharides (LPS) and may be involved in LPS-Toll-like receptor 4 (TLR4) signaling in alveolar epithelial cells. The aim of the present study was to investigate the effect of PALM3 on LPS-induced inflammation and its underlying mechanisms in rat AMs...
September 28, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29039348/the-impact-of-agonists-and-antagonists-of-tlr3-and-tlr9-on-concentrations-of-il-6-il10-and-sil-2r-in-culture-supernatants-of-peripheral-blood-mononuclear-cells-derived-from-patients-with-systemic-lupus-erythematosus
#16
Agnieszka Klonowska-Szymczyk, Liliana Kulczycka-Siennicka, Tadeusz Robak, Piotr Smolewski, Barbara Cebula-Obrzut, Ewa Robak
Toll-like receptors (TLR), especially TLR3, 7 and 9, play an important role in the pathogenesis of systemic lupus erythematosus (SLE). In our study blood was collected from 16 patients with SLE and from 8 healthy volunteers. Concentrations of IL-6, IL-10 and sIL-2R were measured by ELISA in mononuclear cell culture supernatant after 24 hours of stimulation by agonists and antagonists of TLR3 and 9 (for TLR3-poli I/C, resveratrol and for TLR9-ODN2006, IRS 945). Stimulation of TLR9 by ODN2006 led to an increase of IL-6 concentration in cell culture supernatants from the cells of healthy volunteers compared with unstimulated cells from controls...
October 13, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/29039048/sclerosing-and-obstructive-cholangiopathy-in-biliary-atresia-mechanisms-and-association-with-biliary-innate-immunity
#17
REVIEW
Kenichi Harada
Biliary atresia (BA) is histologically characterized by a progressive, sclerosing cholangitis and the obstruction of extrahepatic bile ducts. In terms of the etiology and pathogenesis of BA, several viral infections consisting of dsRNA, including Reoviridae, have been implicated. Human biliary epithelial cells (BECs) possess an innate immune system consisting of Toll-like receptors (TLRs). BECs have negative regulatory mechanisms of TLR tolerance to avoid an excessive inflammatory response to lipopolysaccharide (LPS), a TLR4 ligand; however, they lack the tolerance to poly(I:C) (a synthetic analog of viral dsRNA), a TLR3 ligand...
October 16, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/29038769/polysaccharide-from-black-currant-ribes-nigrum-l-stimulates-dendritic-cells-through-tlr4-signaling
#18
Hiroshi Ashigai, Yuta Komano, Guanying Wang, Yasuji Kawachi, Kazuko Sunaga, Reiko Yamamoto, Ryoji Takata, Mika Miyake, Takaaki Yanai
Black currant (Ribes nigrum) has various beneficial properties for human health. In particular, polysaccharide from black currant was found to be an immunostimulating food ingredient and was reported to have antitumor activity in a mouse model. We named it cassis polysaccharide (CAPS). In a previous study, CAPS administration caused tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) production in vitro and in vivo, but the immunological mechanism of CAPS was not demonstrated. In this study, we revealed the CAPS immunostimulating mechanism in vitro...
2017: Bioscience of Microbiota, Food and Health
https://www.readbyqxmd.com/read/29038465/nmi-and-ifp35-serve-as-proinflammatory-damps-during-cellular-infection-and-injury
#19
Zhikai Xiahou, Xiangli Wang, Juan Shen, Xiaoxiao Zhu, Feng Xu, Rong Hu, Deyin Guo, Henan Li, Yong Tian, Yingfang Liu, Huanhuan Liang
Damage-associated molecular patterns (DAMP) trigger innate immune response and exacerbate inflammation to combat infection and cellular damage. Identifying DAMPs and revealing their functions are thus of crucial importance. Here we report that two molecules, N-myc and STAT interactor (NMI) and interferon-induced protein 35 (IFP35) act as DAMPs and are released by activated macrophages during lipopolysaccharide-induced septic shock or acetaminophen-induced liver injury. We show that extracellular NMI and IFP35 activate macrophages to release proinflammatory cytokines by activating nuclear factor-κB through the Toll-like receptor 4 pathway...
October 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/29037921/tlr-expression-profile-of-human-alveolar-bone-proper-derived-stem-progenitor-cells-and-osteoblasts
#20
Karim M Fawzy El-Sayed, Josephine Boeckler, Christof E Dörfer
Alveolar bone proper-derived mesenchymal stem/progenitor cells (AB-MSCs) and alveolar osteoblasts (OBs) are pivotal cells with positive attributes in regenerative medicine. During regenerative approaches, AB-MSCs may interact with their surrounding environment via their expressed toll-like-receptors (TLRs). This study aimed to depict for the first time the TLRs expression profile of AB-MSCs and OBs. Cells were isolated from human alveolar bone proper, and STRO-1-immunomagnetically sorted to segregate AB-MSCs and OBs...
September 18, 2017: Journal of Cranio-maxillo-facial Surgery
keyword
keyword
35935
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"