keyword
https://read.qxmd.com/read/36574624/the-potential-of-gadolinium-ascorbate-nanoparticles-as-a-safer-contrast-agent
#21
JOURNAL ARTICLE
Ujjala Dey, Arun Chattopadhyay
There have been health concerns raised against the use of gadolinium (Gd)-based magnetic resonance imaging contrast agents. The primary observation is that Gd ions are prone to leaking into the bloodstream, causing nephrogenic systemic fibrosis as one of the side effects. In addition, such leakage of the ions inhibits easy clearance from the body. Herein we propose that Gd-ascorbate nanoparticles could be one of the safer choices as they are rather stable in aqueous dispersion and they do not get affected by Zn or Fe ions in the medium...
December 27, 2022: Journal of Physical Chemistry. B
https://read.qxmd.com/read/36530973/predicting-the-grade-of-meningiomas-by-clinical-radiological-features-a-comparison-of-precontrast-and-postcontrast-mri
#22
JOURNAL ARTICLE
Yuan Yao, Yifan Xu, Shihe Liu, Feng Xue, Bao Wang, Shanshan Qin, Xiubin Sun, Jingzhen He
OBJECTIVES: Postcontrast magnetic resonance imaging (MRI) is important for the differentiation between low-grade (WHO I) and high-grade (WHO II/III) meningiomas. However, nephrogenic systemic fibrosis and cerebral gadolinium deposition are major concerns for postcontrast MRI. This study aimed to develop and validate an accessible risk-scoring model for this differential diagnosis using the clinical characteristics and radiological features of precontrast MRI. METHODS: From January 2019 to October 2021, a total of 231 meningioma patients (development cohort n = 137, low grade/high grade, 85/52; external validation cohort n = 94, low-grade/high-grade, 60/34) were retrospectively included...
2022: Frontiers in Oncology
https://read.qxmd.com/read/36478773/tumor-attentive-segmentation-guided-gan-for-synthesizing-breast-contrast-enhanced-mri-without-contrast-agents
#23
JOURNAL ARTICLE
Eunjin Kim, Hwan-Ho Cho, Junmo Kwon, Young-Tack Oh, Eun Sook Ko, Hyunjin Park
OBJECTIVE: Breast dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a sensitive imaging technique critical for breast cancer diagnosis. However, the administration of contrast agents poses a potential risk. This can be avoided if contrast-enhanced MRI can be obtained without using contrast agents. Thus, we aimed to generate T1-weighted contrast-enhanced MRI (ceT1) images from pre-contrast T1 weighted MRI (preT1) images in the breast. METHODS: We proposed a generative adversarial network to synthesize ceT1 from preT1 breast images that adopted a local discriminator and segmentation task network to focus specifically on the tumor region in addition to the whole breast...
2023: IEEE Journal of Translational Engineering in Health and Medicine
https://read.qxmd.com/read/36464013/adverse-events-associated-with-intra-arterial-administration-of-gadolinium-based-contrast-agents-%C3%A2-a%C3%A2-systematic-review-and%C3%A2-meta-analysis
#24
REVIEW
Chad A MacLeod, Isabelle Gauthier, Matthew S Davenport, Trevor A McGrath, Faizan Khan, Marlise P Dos Santos, Mathew D F McInnes, Nicola Schieda
PURPOSE: To determine the risk of immediate hypersensitivity reactions (HRs), contrast-associated acute kidney injury (CA-AKI), nephrogenic systemic fibrosis (NSF), and gadolinium retention associated with use of intra-arterial gadolinium-based contrast agents (GBCAs). MATERIALS AND METHODS: MEDLINE, Embase, and Cochrane Central Register of Controlled Trials were searched from 1988 (GBCAs approved for clinical use) to March 2021 for studies reporting adverse events associated with intra-arterial administration of GBCAs...
April 2023: Journal of Vascular and Interventional Radiology: JVIR
https://read.qxmd.com/read/36449190/was-there-something-rotten-in-denmark-nephrogenic-system-fibrosis-cases-occurring-in-copenhagen
#25
JOURNAL ARTICLE
Charles L Bennett, Bartlett Witherspoon, Kenneth R Carson, Henrik S Thomsen
More than half of all serious adverse drug reactions are identified seven years after FDA approval. One recent and unusual example involves a syndrome initially termed nephrogenic dermatopathic fibrosis, and then called nephrogenic systemic fibrosis (NSF).
2022: Cancer Treatment and Research
https://read.qxmd.com/read/36211205/nephrogenic-systemic-fibrosis-related-pulmonary-restriction-an-under-appreciated-manifestation-potentially-reversible-with-imatinib-therapy
#26
Jennifer Mansour, Cheralyn Coleman, Fabian Mendoza, Matthew Lammi, Lesley Ann Saketkoo
Nephrogenic systemic fibrosis typically occurs in patients with renal failure and is strongly associated with gadolinium exposure through stimulation of macrophage-activated fibrosis. Patients present with prominent fibrosis of the skin and internal organs. Quality of life is significantly diminished due to impairment from restrictive mobility of large and small joint contractures, pain, and ensuing psychological stress. Nephrogenic systemic fibrosis can be severe and life-threatening. Nephrogenic systemic fibrosis patients reliant on hemodialysis with cutaneous symptoms, defined as hyperpigmentation, hardening, and tethering of skin on the extremities, experience rates of mortality as high as 48%...
October 2022: Journal of Scleroderma and related Disorders
https://read.qxmd.com/read/36197052/ferumoxytol-enhanced-mri-in-children-and-young-adults-state-of-the-art
#27
REVIEW
Lisa C Adams, Praveen Jayapal, Shakthi Kumaran Ramasamy, Wipawee Morakote, Kristen Yeom, Lucia Baratto, Heike E Daldrup-Link
Ferumoxytol is an ultrasmall iron oxide nanoparticle, originally approved in 2009 by the FDA for IV treatment of iron deficiency in adults with chronic kidney disease. Subsequently, its off-label use as an MRI contrast agent has increased in clinical practice, particularly in pediatric patients in North America. Unlike conventional MRI contrast agents that are based on the rare earth metal gadolinium [gadolinium-based contrast agents (GBCAs)], ferumoxytol is biodegradable and carries no potential risk of nephrogenic systemic fibrosis...
October 5, 2022: AJR. American Journal of Roentgenology
https://read.qxmd.com/read/36075185/safety-profile-of-gadoterate-meglumine-on-the-renal-function-of-patients-with-severe-kidney-disease
#28
JOURNAL ARTICLE
Anugayathri Jawahar, Jad El-Bulbul, William Adams, Cara Joyce, Joseph Yacoub, Ari Goldberg
OBJECTIVE: Intravenous administration of gadolinium-based contrast agents (GBCA) in patients with impaired renal function has been of concern to primary care physicians due to the potential worsening of renal dysfunction and nephrogenic systemic fibrosis (NSF). Our objective was to compare the potential change in estimated glomerular filtration rate (eGFR) in patients with known severe renal dysfunction (eGFR <30 ml/min), following Gadoterate meglumine (GM) administration with patients who do not receive contrast...
November 2022: Clinical Imaging
https://read.qxmd.com/read/36010167/nephrogenic-systemic-fibrosis-in-patients-with-chronic-kidney-disease-after-the-use-of-gadolinium-based-contrast-agents-a-review-for-the-cardiovascular-imager
#29
REVIEW
Sebastian Gallo-Bernal, Nasly Patino-Jaramillo, Camilo A Calixto, Sergio A Higuera, Julian F Forero, Juliano Lara Fernandes, Carlos Góngora, Michael S Gee, Brian Ghoshhajra, Hector M Medina
Gadolinium-enhanced cardiac magnetic resonance has revolutionized cardiac imaging in the last two decades and has emerged as an essential and powerful tool for the characterization and treatment guidance of a wide range of cardiovascular diseases. However, due to the high prevalence of chronic renal dysfunction in patients with cardiovascular conditions, the risk of nephrogenic systemic fibrosis (NSF) after gadolinium exposure has been a permanent concern. Even though the newer macrocyclic agents have proven to be much safer in patients with chronic kidney disease and end-stage renal failure, clinicians must fully understand the clinical characteristics and risk factors of this devastating pathology and maintain a high degree of suspicion to prevent and recognize it...
July 28, 2022: Diagnostics
https://read.qxmd.com/read/35972786/physico-chemical-characterization-of-a-highly-rigid-gd-iii-complex-formed-with-a-phenanthroline-derivative-ligand
#30
JOURNAL ARTICLE
Balázs Váradi, Norbert Lihi, Szilvia Bunda, Antónia Nagy, Gréta Simon, Mónika Kéri, Gábor Papp, Gyula Tircsó, David Esteban-Gómez, Carlos Platas-Iglesias, Ferenc K Kálmán
The discovery of the nephrogenic systemic fibrosis (NSF) and its link with the in vivo dissociation of certain Gd(III)-based contrast agents (CAs) applied in the magnetic resonance imaging (MRI) induced a still growing research to replace the compromised agents with safer alternatives. In recent years, several ligands were designed to exploit the luminescence properties of the lanthanides, containing structurally constrained aromatic moieties, which may form rigid Gd(III) complexes. One of these ligands is (1,10-phenanthroline-2,9-diyl)bis(methyliminodiacetic acid) (H4 FENTA) designed and synthesized to sensitize Eu(III) and Tb(III) luminescence...
August 16, 2022: Inorganic Chemistry
https://read.qxmd.com/read/35971987/effective-mitigation-of-gadolinium-deposition-using-the-bidentate-hydroxypyridinone-ligand-me-3-2-hopo
#31
JOURNAL ARTICLE
Qiwen Sun, Xiaomei Wang, Cen Shi, Jingwen Guan, Lanhua Chen, Yumin Wang, Shuao Wang, Juan Diwu
With the extensive usage of gadolinium-based contrast agents (GBCAs) in magnetic resonance imaging (MRI), gadolinium deposition has been observed in the brain, kidneys, liver, etc ., and this is also closely related to the development of nephrogenic systemic fibrosis (NSF) in patients with renal dysfunction. Chelation, thereby promoting the elimination of deposited Gd(III), seems to be promising for alleviating these problems. Despite many ligands suitable for chelation therapy having been studied, the decorporation of transition metals ( e...
August 30, 2022: Dalton Transactions: An International Journal of Inorganic Chemistry
https://read.qxmd.com/read/35894008/contrast-enhanced-ultrasound-compared-with-mri-and-ct-in-the-evaluation-of-post-renal-transplant-complications
#32
REVIEW
Emanuele David, Giovanni Del Gaudio, Francesco Maria Drudi, Vincenzo Dolcetti, Patrizia Pacini, Antonio Granata, Renzo Pretagostini, Manuela Garofalo, Antonio Basile, Maria Irene Bellini, Vito D'Andrea, Mariano Scaglione, Richard Barr, Vito Cantisani
Renal transplantation (RT) is the treatment of choice for end-stage renal disease, significantly improving patients' survival and quality of life. However, approximately 3-23% of patients encounter post-operative complications, and radiology plays a major role for their early detection and treatment or follow-up planning. CT and MRI are excellent imaging modalities to evaluate renal transplant post-operative course; nevertheless, they are both associated with a high cost and low accessibility, as well as some contraindications, making them not feasible for all patients...
June 28, 2022: Tomography: a Journal for Imaging Research
https://read.qxmd.com/read/35887726/gray-scale-color-doppler-spectral-doppler-and-contrast-enhanced-renal-artery-ultrasound-imaging-techniques-and-features
#33
REVIEW
Byung Kwan Park
Renal artery stenosis (RAS) is increasingly being detected in elderly patients as life expectancy increases. RAS induces hypertension or reduces renal function. Computed tomography or magnetic resonance angiography are objective in detecting RAS but may cause iodine-induced nephrotoxicity or nephrogenic systemic fibrosis in patients with RAS. Ultrasound (US) is, by contrast, a noninvasive and real-time imaging modality useful in patients with reduced renal function. Renal US is not as sensitive for detecting RAS because this technique indirectly assesses the renal artery by analyzing intrarenal hemodynamic changes...
July 7, 2022: Journal of Clinical Medicine
https://read.qxmd.com/read/35782562/evaluation-of-the-abdominal-aorta-and-external-iliac-arteries-using-three-dimensional-time-of-flight-three-dimensional-electrocardiograph-gated-fast-spin-echo-and-contrast-enhanced-magnetic-resonance-angiography-in-clinically-healthy-cats
#34
JOURNAL ARTICLE
Minju Lee, Minjung Ko, Jisoo Ahn, Jiyoung Ahn, Jin Yu, Jinhwa Chang, Sukhoon Oh, Dongwoo Chang
Arterial thromboembolism is associated with high morbidity and mortality rates in cats. Definitive diagnosis requires advanced imaging modalities, such as computed tomography angiography (CTA) and contrast-enhanced (CE) magnetic resonance angiography (MRA). However, CTA involves exposure to a large amount of ionized radiation, and CE-MRA can cause systemic nephrogenic fibrosis. Non-contrast-enhanced (NE) MRA can help accurately diagnose vascular lesions without such limitations. In this study, we evaluated the ability of NE-MRA using three-dimensional electrocardiograph-gated fast spin-echo (3D ECG-FSE) and 3D time-of-flight (3D TOF) imaging to visualize the aorta and external iliac arteries in clinically healthy cats and compared the results with those obtained using CE-MRA...
2022: Frontiers in Veterinary Science
https://read.qxmd.com/read/35777831/radiographic-contrast-media-and-the-kidney
#35
JOURNAL ARTICLE
Winn Cashion, Steven D Weisbord
AKI is a potential complication of intravascular iodinated contrast exposure. Contrast-associated AKI, which typically manifests as small and transient decrements in kidney function that develop within several days of contrast administration, is associated with serious adverse outcomes, including progressive kidney dysfunction and death. However, a causal link between the small increases in serum creatinine that characteristically occur with contrast-associated AKI and serious adverse outcomes remains unproven...
August 2022: Clinical Journal of the American Society of Nephrology: CJASN
https://read.qxmd.com/read/35740867/gadolinium-in-medical-imaging-usefulness-toxic-reactions-and-possible-countermeasures-a-review
#36
REVIEW
Lennart Blomqvist, Gunnar F Nordberg, Valeria M Nurchi, Jan O Aaseth
Gadolinium (Gd) is one of the rare-earth elements. The properties of its trivalent cation (Gd3+ ) make it suitable to serve as the central ion in chelates administered intravenously to patients as a contrast agent in magnetic resonance imaging. Such Gd-chelates have been used for more than thirty years. During the past decades, knowledge has increased about potential harmful effects of Gd-chelates in patients with severe renal dysfunction. In such patients, there is a risk for a potentially disabling and lethal disease, nephrogenic systemic fibrosis...
May 24, 2022: Biomolecules
https://read.qxmd.com/read/35652711/zeroing-on-gadolinium-to-complement-intravascular-ultrasound-in-zero-contrast-percutaneous-coronary-interventions
#37
JOURNAL ARTICLE
Hady Lichaa
Many techniques have been developed to minimize the risk of contrast-induced nephropathy (CIN) in patients with chronic kidney disease (CKD) through drastic reductions in iodinated contrast volume and the use of intravascular ultrasound (IVUS). While some of the described techniques completely avoid contrast use and rely on transthoracic echocardiography to check for potential pericardial bleeding, this strategy may miss or delay the treatment of potentially life-threatening complications. We hereby propose the use of group II gadolinium (Gd)-based contrast agents, instead of iodinated contrast, to complement IVUS, in order to achieve the goal of zero-contrast percutaneous coronary intervention, without raising the risk of CIN...
June 2022: Journal of Invasive Cardiology
https://read.qxmd.com/read/35612906/gadolinium-based-contrast-agents-updates-and-answers-to-typical-questions-regarding-gadolinium-use
#38
REVIEW
Benjamin Y C Cheong, James M Wilson, Ourania A Preventza, Raja Muthupillai
Gadolinium-based contrast agents have expanded the diagnostic usefulness and capability of magnetic resonance imaging. Despite their highly favorable safety profile, these agents have been associated with nephrogenic systemic fibrosis in a small number of patients who have advanced kidney disease. Recently, trace amounts of gadolinium deposition in the brain and other organs have been reported after contrast exposure, even in patients with normal renal function. In this review, we provide a brief overview of recent updates and discuss typical clinical situations related to the use of gadolinium-based contrast agents...
May 1, 2022: Texas Heart Institute Journal
https://read.qxmd.com/read/35532771/nephrogenic-systemic-fibrosis-with-osseous-metaplasia-in-a-kidney-pancreas-transplant-patient
#39
JOURNAL ARTICLE
Joann Le Borgne de Lavillandre, Fanny Buron, Emilie Ducroux, Jean Kanitakis
A French (Caucasian) woman with a history of nonobstructive hypertrophic cardiopathy, type 1 diabetes mellitus, cataract, and ante-hypophysary insufficiency had undergone multiple magnetic resonance imaging (MRI) studies. She had developed end-stage renal disease (ESRD) and had undergone hemodialysis for 10 years before receiving a kidney-pancreas allotransplantation at the age of 48 years. She received antithymocyte globulins as induction immunosuppression and steroids (5 mg/d), mycophenolate mofetil (2 g/d), and tacrolimus (5 mg/d) as maintenance immunosuppression...
2022: Skinmed
https://read.qxmd.com/read/35498882/cutaneous-manifestations-of-acute-kidney-injury
#40
REVIEW
Gavin A Esson, Amaani B Hussain, Simon J Meggitt, Nick J Reynolds, John A Sayer
Acute kidney injury (AKI) is a common medical problem with a multitude of aetiologies. Prompt diagnosis and management is key in the prevention of complications. Cutaneous signs can often give diagnostic clues of underlying systemic diseases causing AKI. This review summarizes cutaneous findings of diseases causing AKI in adults. Knowledge of such cutaneous signs could lead to earlier diagnosis of underlying kidney disease and facilitate management strategies in a timely manner. Acute interstitial nephritis, polyarteritis nodosa, Kawasaki's disease, granulomatosis with polyangiitis (previously Wegener's granulomatosis), microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis (previously Churg-Strauss syndrome), Henoch-Schönlein purpura, cryoglobulinaemia, Sjögren's syndrome, systemic sclerosis, nephrogenic systemic fibrosis, dermatomyositis, systemic lupus erythematosus, amyloidosis and cholesterol embolization syndrome were highlighted as diseases causing AKI with cutaneous manifestations...
May 2022: Clinical Kidney Journal
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