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Nephrogenic systemic fibrosis

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https://www.readbyqxmd.com/read/27822733/-cutaneous-manifestations-in-renal-diseases
#1
M Schmid-Simbeck, A Udvardi, B Volc-Platzer
In addition to general skin changes like pallor or dryness and the frequent, often excruciating nephrogenic pruritus, specific diseases in patients with renal failure may occur. Acquired perforating dermatoses are usually also highly pruritic. Calciphylaxis is a severe disease with poor prognosis. Nonhealing wounds with superinfection and progression to sepsis are characteristic. Bullous lesions can be caused by disturbances in porphyrin metabolism. Nephrogenic systemic fibrosis is a disease which was first described in 2000...
December 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/27779713/a-novel-blood-pooling-mr-contrast-agent-carboxymethyl-diethylaminoethyl-dextran-magnetite
#2
Akinaga Sonoda, Norihisa Nitta, Keiko Tsuchiya, Ayumi Nitta-Seko, Shinichi Ohta, Hideji Otani, Kiyoshi Murata
Gadofosveset trisodium is available as a prolonged pooling vascular contrast agent for magnetic resonance imaging. As gadolinium (Gd)-based agents may increase the risk for nephrogenic systemic fibrosis in patients with severe renal insufficiency, the present study synthesized carboxymethyl-diethylaminoethyl dextran magnetite (CMEADM) particles as a blood-pooling, non-Gd‑based contrast agent. CMEADM particles carry a negative or positive charge due to the binding of amino and carboxyl groups to the hydroxyl group of dextran...
October 21, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27760564/the-diagnostic-value-of-non-contrast-enhanced-quiescent-interval-single-shot-qiss-magnetic-resonance-angiography-at-3t-for-lower-extremity-peripheral-arterial-disease-in-comparison-to-ct-angiography
#3
Gang Wu, Jun Yang, Tianjing Zhang, John N Morelli, Shivraman Giri, Xiaoming Li, Wenlin Tang
BACKGROUND: The high incidence of renal insufficiency in patients with Peripheral Arterial Disease raises the concern for nephrogenic systemic fibrosis (NSF) with respect to contrast enhanced MRA. The risk of NSF is eliminated with non-contrast enhanced magnetic resonance angiography. The purpose of the current study is to compare image quality and diagnostic performance of non-contrast enhanced Quiescent Interval Single Shot (QISS) magnetic resonance angiography at 3 T versus CT angiography for evaluation of lower extremity Peripheral Arterial Disease (PAD)...
October 20, 2016: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/27748714/incidence-and-risk-factors-for-gadolinium-based-contrast-agent-immediate-reactions
#4
James R Costello, Bobby Kalb, Diego R Martin
Since their clinical introduction in 1988, gadolinium-based contrast agents (GBCAs) have demonstrated an excellent safety profile with a reported acute adverse reaction rate ranging from 0.01% to 2%. By comparison, the acute adverse reaction rate of low osmolar nonionic computed tomography contrast agents (CTCs) ranges from 0.7% to 3.1%. Many of the risk factors associated with CTC reactions (drug allergies, asthma, atopy, prior contrast reaction) also point toward an increased incidence of acute adverse events to GBCAs...
December 2016: Topics in Magnetic Resonance Imaging: TMRI
https://www.readbyqxmd.com/read/27726239/observational-study-on-the-safety-profile-of-gadoterate-meglumine-in-35-499-patients-the-secure-study
#5
Philippe Soyer, Anthony Dohan, Deepak Patkar, Andreas Gottschalk
PURPOSE: To investigate the safety of gadoterate meglumine and identify the incidence of nephrogenic systemic fibrosis (NSF). MATERIALS AND METHODS: An international prospective observational study was conducted from November 2008 to June 2013. A total of 35,499 adults and children who were scheduled to undergo contrast-enhanced MRI using gadoterate meglumine were analyzed (female, 53.1%; mean age: 49.5 years; range: 0-98 years). At least 3-month follow-up was planned for patients with an estimated creatinine clearance or glomerular filtration rate <60 mL/min (/1...
October 11, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27720805/gadolinium-tissue-deposition-in-brain-and-bone
#6
Nozomu Murata, Kiyoko Murata, Luis F Gonzalez-Cuyar, Kenneth Maravilla
Until recognition of the association of nephrogenic systemic fibrosis (NSF) and gadolinium based contrast agents (GBCA) in 2006, these agents were considered extremely safe and without major adverse effects. Even after the recognition of NSF, most physicians considered all GBCAs to be safe when used in patients with normal renal function. This belief has been called into question with the discovery by Kanda in 2014 that Gd is deposited in brain tissue in patients with normal kidney function. Since that initial report, there have been a number of important studies analyzing the effects of various GBCAs in brain using MR T1 signal intensity measurements and postmortem tissue analyses with inductively coupled plasma mass spectrometry...
October 5, 2016: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/27683230/effects-of-gadodiamide-on-cell-proliferation-and-collagen-production-in-cultured-human-dermal-fibroblasts
#7
Yumi Ozawa, Shujiro Hayashi, Yoichiro Hamasaki, Atsushi Hatamochi
Nephrogenic systemic fibrosis (NSF) is a disease characterized by fibrosis of the systemic organs in patients with renal failure. Following the findings of recent epidemiological studies and the finding of gadolinium (Gd) in the skin tissue of NSF patients, it is now definitely known that the use of Gd contrast agents can trigger NSF. To date, however, the exact mechanism underlying the induction of fibrosis in various organs by Gd remains unexplained. This study was undertaken to evaluate the influence of Gd on the proliferation activity and collagen production of cultured fibroblasts...
September 28, 2016: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27633865/exploring-the-elusive-link-between-subclinical-fibrosis-and-clinical-events-in-end-stage-renal-disease-does-cardiac-magnetic-resonance-imaging-hold-the-key
#8
Gautam R Shroff, Paolo Raggi
Extensive myocardial fibrosis is known to occur in patients undergoing dialysis due to a variety of mechanisms not necessarily restricted to coronary artery disease. Fibrosis may predispose to reentry arrhythmias and long-term myocardial dysfunction, and sudden death and congestive heart failure are the most frequent causes of death in patients undergoing renal replacement therapy. Despite the high accuracy of magnetic resonance for imaging of myocardial fibrosis, its use has been restricted by the risk of inducing nephrogenic systemic sclerosis with the injection of gadolinium...
October 2016: Kidney International
https://www.readbyqxmd.com/read/27599330/association-between-mri-exposure-during-pregnancy-and-fetal-and-childhood-outcomes
#9
Joel G Ray, Marian J Vermeulen, Aditya Bharatha, Walter J Montanera, Alison L Park
IMPORTANCE: Fetal safety of magnetic resonance imaging (MRI) during the first trimester of pregnancy or with gadolinium enhancement at any time of pregnancy is unknown. OBJECTIVE: To evaluate the long-term safety after exposure to MRI in the first trimester of pregnancy or to gadolinium at any time during pregnancy. DESIGN, SETTING, AND PARTICIPANTS: Universal health care databases in the province of Ontario, Canada, were used to identify all births of more than 20 weeks, from 2003-2015...
September 6, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27580520/gadolinium-toxicity-iron-and-ferroportin-as-central-targets
#10
Sundararaman Swaminathan
Gadolinium-based magnetic resonance (MR) contrast agents (GBCM) causes a devastating systemic fibrosing illness, nephrogenic systemic fibrosis (NSF), in patients with reduced kidney function. GBCM targets iron-recycling CD163- and ferroportin-expressing macrophages to release labile iron that mediates gadolinium toxicity and NSF. GBCA might similarly target iron-rich, ferroportin-expressing structures such as globus pallidus and cerebellar dentate nucleus in the brain to result in metal accumulation and potential toxicity...
August 28, 2016: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/27573129/unenhanced-3d-turbo-spin-echo-mr-angiography-of-lower-extremity-arteries-comparison-with-128-mdct-angiography
#11
Hakan Demirtaş, Tuna Parpar, Bumin Değirmenci, Mustafa Kara, Ahmet Orhan Çelik, Ayşe Umul, Mustafa Kayan, Ömer Yılmaz
PURPOSE: This study aimed to investigate the feasibility and diagnostic power of unenhanced 3D turbo spin echo MR angiography sequence (a technique based on subtraction of corresponding images acquired in diastole and systole, Syngo Native Space-Siemens healthcare) to identify peripheral artery disease (PAD). MATERIALS AND METHODS: Thirty patients (619 arterial segments in total) suspected with PAD and who were assessed with lower extremity MDCT angiography were examined starting from the level of aortic bifurcation for both lower extremities by 3D native space MR angiography...
August 29, 2016: La Radiologia Medica
https://www.readbyqxmd.com/read/27529464/gadobutrol-in-renally-impaired-patients-results-of-the-grip-study
#12
Henrik J Michaely, Manuela Aschauer, Hannes Deutschmann, Georg Bongartz, Matthias Gutberlet, Ramona Woitek, Birgit Ertl-Wagner, Walter Kucharczyk, Renate Hammerstingl, Francesco De Cobelli, Martin Rosenberg, Thomas Balzer, Jan Endrikat
OBJECTIVE: The aim of this study was to assess the potential risk of gadobutrol-enhanced magnetic resonance imaging (MRI) in patients with moderate to severe renal impairment for the development of nephrogenic systemic fibrosis (NSF). MATERIALS AND METHODS: We performed a prospective, international, multicenter, open-label study in 55 centers. Patients with moderate to severe renal impairment scheduled for any gadobutrol-enhanced MRI were included. All patients received a single intravenous bolus injection of gadobutrol at a dose of 0...
January 2017: Investigative Radiology
https://www.readbyqxmd.com/read/27504997/3-tesla-diffusion-tensor-imaging-in-autosomal-dominant-polycystic-kidney-disease-the-nephrologist-s-point-of-view
#13
Rosaria Lupica, Enricomaria Mormina, Antonio Lacquaniti, Domenico Trimboli, Biagio Bianchimano, Silvia Marino, Placido Bramanti, Marcello Longo, Michele Buemi, Francesca Granata
BACKGROUND/AIMS: CT, MRI and ultrasound are currently used for screening and follow-up of individuals affected by autosomal dominant polycystic kidney disease (ADPKD). Dynamic contrast-enhanced MRI studies renal perfusion after gadolinium administration, with possible side effects, such as nephrogenic systemic fibrosis. The aim of our study was to evaluate the clinical application of 3 Tesla (3T)-diffusion tensor image (DTI) in ADPKD patients, correlating its parameters, such as fractional anisotropy (FA), and apparent diffusion coefficient (ADC) with kidney function tests...
2016: Nephron
https://www.readbyqxmd.com/read/27504794/adverse-reactions-to-gadoterate-meglumine-review-of-over-25-years-of-clinical-use-and-more-than-50-million-doses
#14
Eric de Kerviler, Kenneth Maravilla, Jean-François Meder, Olivier Naggara, Corinne Dubourdieu, Vincent Jullien, Pierre Desché
OBJECTIVE: The aim of this study was to evaluate the safety profile of gadoterate meglumine from clinical trials, postmarketing observational studies, and pharmacovigilance reports of adverse drug reactions (ADRs) encompassing 25 years of clinical use and over 50 million administered doses. MATERIALS AND METHODS: Assessment of the safety of gadoterate meglumine through processing and review of all safety data was collected after magnetic resonance imaging procedures...
September 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27503805/defining-myocardial-tissue-abnormalities-in-end-stage-renal-failure-with-cardiac-magnetic-resonance-imaging-using-native-t1-mapping
#15
Elaine Rutherford, Mohammed A Talle, Kenneth Mangion, Elizabeth Bell, Samuli M Rauhalammi, Giles Roditi, Christie McComb, Aleksandra Radjenovic, Paul Welsh, Rosemary Woodward, Allan D Struthers, Alan G Jardine, Rajan K Patel, Colin Berry, Patrick B Mark
Noninvasive quantification of myocardial fibrosis in end-stage renal disease is challenging. Gadolinium contrast agents previously used for cardiac magnetic resonance imaging (MRI) are contraindicated because of an association with nephrogenic systemic fibrosis. In other populations, increased myocardial native T1 times on cardiac MRI have been shown to be a surrogate marker of myocardial fibrosis. We applied this method to 33 incident hemodialysis patients and 28 age- and sex-matched healthy volunteers who underwent MRI at 3...
October 2016: Kidney International
https://www.readbyqxmd.com/read/27503115/unenhanced-respiratory-navigated-native-%C3%A2-truefisp-magnetic-resonance-angiography-in-the-evaluation-of-renal-arteries-comparison-with-contrast-enhanced-magnetic-resonance-angiography
#16
B Değirmenci, M Kara, V Kıdır, S İnal, T Sezer, A Umul, H Orhan, A O Çelik, H Demirtaş, Ö Yilmaz
PURPOSE: To compare unenhanced three-dimensional (3D) NATIVE(®) true fast imaging with steady-state precession (TrueFISP) magnetic resonance (MR) angiography with the more conventional MR angiography technique obtained after intravenous administration of a gadolinium chelate in the evaluation of renal arteries and their branches in patients with suspected renal artery stenosis. MATERIALS AND METHODS: A total of 39 patients (25 men, 14 women) with a mean age of 51...
August 5, 2016: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/27367314/adverse-effects-of-gadolinium-based-contrast-agents-changes-in-practice-patterns
#17
Reza Forghani
Gadolinium-based contrast agents have been used for magnetic resonance imaging (MRI) examinations since the late 1980s with an excellent overall cumulative safety record. Initially favored for use in patients with renal impairment because of lack of significant nephrotoxic effect at clinical doses, in 2006, multiple reports convincingly linked the rare but serious disease nephrogenic systemic fibrosis to the administration of gadolinium-based contrast agents in patients with severe renal failure. This in turn led to new policies on administration of these agents, resulting in changes in practice patterns that have virtually resulted in the elimination of the disease after the year 2009...
August 2016: Topics in Magnetic Resonance Imaging: TMRI
https://www.readbyqxmd.com/read/27367312/alternatives-to-gbca-are-we-there-yet
#18
Jeffrey R Wesolowski, Andrew Kaiser
Gadolinium has been widely used as the contrast agent of choice for magnetic resonance imaging (MRI). However, gadolinium administration is not always desired due to its inherent enhancement properties and potential side effects (nephrogenic systemic fibrosis). This article reviews gadolinium alternatives, iron-, and manganese- based agents, and their current clinical usage for contrast-enhanced MRI examinations.
August 2016: Topics in Magnetic Resonance Imaging: TMRI
https://www.readbyqxmd.com/read/27276056/a-milestone-approval-of-ceus-for-diagnostic-liver-imaging-in-adults-and-children-in-the-usa
#19
K Seitz, D Strobel
The approval of microbubbles with the inert gas sulfur hexafluoride (SF6) and a palmitic acid shell (SonoVue(®), Bracco Geneva, CH) for the diagnostic imaging of liver tumors in adults and children by the FDA in the United States represents a milestone for contrast-enhanced ultrasound (CEUS).This warrants a look back at the history of the development of CEUS. The first publications based on echocardiographic observations of right ventricular contrast phenomena caused by tiny air bubbles following i. v...
June 2016: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/27244570/minor-changes-in-the-macrocyclic-ligands-but-major-consequences-on-the-efficiency-of-gold-nanoparticles-designed-for-radiosensitization
#20
G Laurent, C Bernhard, S Dufort, G Jiménez Sánchez, R Bazzi, F Boschetti, M Moreau, T H Vu, B Collin, A Oudot, N Herath, H Requardt, S Laurent, L Vander Elst, R Muller, M Dutreix, M Meyer, F Brunotte, P Perriat, F Lux, O Tillement, G Le Duc, F Denat, S Roux
Many studies have been devoted to adapting the design of gold nanoparticles to efficiently exploit their promising capability to enhance the effects of radiotherapy. In particular, the addition of magnetic resonance imaging modality constitutes an attractive strategy for enhancing the selectivity of radiotherapy since it allows the determination of the most suited delay between the injection of nanoparticles and irradiation. This requires the functionalization of the gold core by an organic shell composed of thiolated gadolinium chelates...
June 9, 2016: Nanoscale
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