keyword
MENU ▼
Read by QxMD icon Read
search

Nephrogenic systemic fibrosis

keyword
https://www.readbyqxmd.com/read/29110904/retention-of-gadolinium-compounds-used-in-magnetic-resonance-imaging-a-critical-review-and-the-recommendations-of-regulatory-agencies
#1
L Martí-Bonmatí, E Martí-Bonmatí
The Spanish Agency for Drugs and Healthcare Products (AEMPS), based on the recommendations of the European Committee for Risk Assessment in Pharmacovigilance, established on 13 March 2017 that linear gadolinium-based MR contrast media, such as MultiHance, Omniscan, Magnevist (currently not marketed) and Optimark (no longer marketed in Spain), the clinical benefits do not outweigh the potential risks derived from their use. AEMPS recommends to suspend its marketing for general use based on the retention of these compounds in the brain...
October 27, 2017: Radiología
https://www.readbyqxmd.com/read/29025775/a-unique-case-of-nephrogenic-systemic-fibrosis-from-gadolinium-exposure-in-a-patient-with-normal-egfr
#2
Sadichhya Lohani, Jon Golenbiewski, Abhishek Swami, Alexandra Halalau
A 57-year-old woman presented with swelling and thickening of the skin of the lower extremities. Three months prior to presentation, patient had MRI with gadolinium as part of an evaluation for suspected pancreatic malignancy. Creatinine levels at the time of gadolinium exposure were 0.9-1.2 mg/dL, with a corresponding estimated glomerular filtration rate of 64 mL/min/1.73m(2) by modification of diet in renal disease equation. Twenty-four-hour urine creatinine clearance was performed as an outpatient following development of symptoms...
October 11, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28965904/nephrogenic-systemic-fibrosis-a-survey-of-the-use-of-gadolinium-based-contrast-agents-in-ghana
#3
A D Piersson, P N Gorleku
INTRODUCTION: The aim of this study is to identify current practice of administration of gadolinium-based contrast agents (GBCAs) in Ghana. METHOD: A total of 13 MRI (magnetic resonance imaging) facilities were sent a survey questionnaire to request information on their current practice with the use of GBCAs. RESULTS: Gadodiamide, a high risk GBCA accounted for 67% of first line agents. 5 (42%) had a departmental protocol on the administration of GBCAs with regards to its association with nephrogenic systemic fibrosis (NSF)...
November 2017: Radiography
https://www.readbyqxmd.com/read/28964467/safety-of-contrast-material-use-in-children
#4
REVIEW
Bruno P Soares, Maarten H Lequin, Thierry A G M Huisman
Iodinated and gadolinium-based contrast materials have excellent safety profiles for use in pediatric computed tomography and MR imaging. The rate of acute adverse reactions and contrast-induced nephropathy is lower than in adults. The relationship between nephrogenic systemic fibrosis and gadolinium administration is well established and only a small number of children suffer from this debilitating disorder. The recent finding of gadolinium deposition in the brain of patients with normal renal function has renewed concerns regarding its long-term toxicity...
November 2017: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/28964458/historical-perspective-of-imaging-contrast-agents
#5
REVIEW
Carlos A Zamora, Mauricio Castillo
Contrast agents were introduced early in the history of medical imaging. Iodine-based intravascular agents became the radiographic compounds of choice and refinements of their chemical structures led to the highly tolerated low-osmolarity agents in use today. Gadolinium became the most popular compound for MR imaging; however, recognition of nephrogenic systemic fibrosis and in vivo dechelation intensified research on their safety profile. Ultrasonography contrast media evolved from manual injections of air through agitated saline solutions to microbubbles with different gases...
November 2017: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/28934030/metabolomic-analysis-of-n-acetylcysteine-protection-of-injury-from-gadolinium-dtpa-contrast-agent-in-rats-with-chronic-renal-failure
#6
Chuanling Wan, Rong Xue, Youyang Zhan, Yijie Wu, Xiaojing Li, Fengkui Pei
Gadolinium-based contrast agents (GBCAs) are frequently used to enhance the diagnostic efficacy of magnetic resonance imaging. On the other hand, the association between GBCA administration in patients with advanced renal disease and nephrogenic systemic fibrosis (NSF) was also noted. NSF is a systemic disorder characterized by widespread tissue fibrosis that may lead to death. N-acetylcysteine (NAC) protects rats from injury induced by gadolinium-based contrast agents, but the underlying mechanisms remain unclear...
September 2017: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/28900045/gbcas-and-risk-for-nephrogenic-systemic-fibrosis-a-literature-review
#7
Asher Street Beam, Kristi G Moore, Savannah N Gillis, Kala F Ford, Tyler Gray, Anne Howard Steinwinder, Alexa Graham
PURPOSE: To examine the risks of using of gadolinium-based contrast agents (GBCAs) in magnetic resonance (MR) imaging and explore strategies to reduce the likeliness of adverse effects in patients who might be at risk for developing nephrogenic system fibrosis (NSF). METHODS: A search of 3 scholarly databases was performed to identify articles that discuss adverse reactions to GBCAs, specifically relating to kidney function, in MR examinations. A total of 20 peer-reviewed articles were analyzed...
July 2017: Radiologic Technology
https://www.readbyqxmd.com/read/28881830/value-of-quantitative-magnetic-resonance-imaging-t1-relaxometry-in-predicting-contrast-enhancement-in-glioblastoma-patients
#8
Elke Hattingen, Andreas Müller, Alina Jurcoane, Burkhard Mädler, Philip Ditter, Hans Schild, Ulrich Herrlinger, Martin Glas, Sied Kebir
SUMMARIZING THE IMPORTANCE OF THE STUDY: The repetitive usage of gadolinium-based contrast agents (GBCA) is critical for magnetic resonance imaging (MRI) evaluation of tumor burden in glioblastoma patients. It is also a crucial tool for determination of radiographical response to treatment. GBCA injection, however, comes with a 2.4% rate of adverse events including life-threatening conditions such as nephrogenic systemic fibrosis (NSF). Moreover, GBCA have been shown to be deposited in brain tissue of patients even with an intact blood-brain barrier (BBB)...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28836191/human-fibrotic-diseases-current-challenges-in-fibrosis-research
#9
Joel Rosenbloom, Edward Macarak, Sonsoles Piera-Velazquez, Sergio A Jimenez
Human fibrotic diseases constitute a major health problem worldwide owing to the large number of affected individuals, the incomplete knowledge of the fibrotic process pathogenesis, the marked heterogeneity in their etiology and clinical manifestations, the absence of appropriate and fully validated biomarkers, and, most importantly, the current void of effective disease-modifying therapeutic agents. The fibrotic disorders encompass a wide spectrum of clinical entities including systemic fibrotic diseases such as systemic sclerosis (SSc), sclerodermatous graft vs...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28744073/gadolinium-based-contrast-agents-in-current-practice-risks-of-accumulation-and-toxicity-in-patients-with-normal-renal-function
#10
Anju Ranga, Yatish Agarwal, Kanika J Garg
Despite being decked as the most prized compounds in the nugget box of contrast agents for clinical radiologists, and carrying an indisputable tag of safety of the US Food and Drug Administration for close to three decades, all may not be seemingly well with the family of gadolinium compounds. If the first signs of violations of primum non nocere in relation to gadolinium-based contrast agents (GBCAs) appeared in the millennium year with the first published report of skin fibrosis in patients with compromised renal function, the causal relationship between the development of nephrogenic systemic fibrosis (NSF) and GBCAs, first proposed by two European groups in 2006, further precluded their use in renocompromised patients...
April 2017: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/28738858/erythema-nodosum-masking-nephrogenic-systemic-fibrosis-as-initial-skin-manifestation
#11
Kar Wah Fuah, Christopher Thiam Seong Lim
BACKGROUND: Nephrogenic systemic fibrosis (NSF) is a complication of the gadolinium-based contrast agent used in imaging studies. It is typically characterised by hard, erythematous and indurated skin plaques with surrounding subcutaneous oedema. Distinct papules and subcutaneous nodules can also be seen. Fibrocytes in NSF are immunohistochemically positive for CD34. CASE PRESENTATION: We present a case of NSF occurred after gadolinium exposure in which the initial presentation mimics an erythema nodosum (EN)-like picture...
July 24, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28731375/no-incidence-of-nephrogenic-systemic-fibrosis-after-gadobenate-dimeglumine-administration-in-patients-undergoing-dialysis-or-those-with-severe-chronic-kidney-disease
#12
Diego R Martin, Bobby Kalb, Ankush Mittal, Khalil Salman, Srinivasan Vedantham, Pardeep K Mittal
Purpose To determine the incidence of nephrogenic systemic fibrosis (NSF) in patients with severe chronic kidney disease (CKD) who underwent a uniform protocol for contrast material-enhanced magnetic resonance (MR) imaging with a gadolinium-based contrast agent (GBCA). Materials and Methods This retrospective, single-center, institutional review board-approved, HIPAA-compliant study included 3819 patients with severe (stage 4 or 5) CKD who underwent gadobenate dimeglumine-enhanced MR imaging as part of a preoperative evaluation for potential renal transplantation from January 2008 to February 2014...
July 21, 2017: Radiology
https://www.readbyqxmd.com/read/28712039/cutaneous-manifestations-of-scleroderma-and-scleroderma-like-disorders-a-comprehensive-review
#13
REVIEW
Caterina Ferreli, Giulia Gasparini, Aurora Parodi, Emanuele Cozzani, Franco Rongioletti, Laura Atzori
Scleroderma refers to an autoimmune connective tissue fibrosing disease, including three different subsets: localized scleroderma, limited cutaneous systemic sclerosis, and diffuse cutaneous systemic sclerosis with divergent patterns of organ involvement, autoantibody profiles, management, and prognostic implications. Although systemic sclerosis is considered the disease prototype that causes cutaneous sclerosis, there are many other conditions that can mimic and be confused with SSc. They can be classified into immune-mediated/inflammatory, immune-mediated/inflammatory with abnormal deposit (mucinoses), genetic, drug-induced and toxic, metabolic, panniculitis/vascular, and (para)neoplastic disorders according to clinico-pathological and pathogenetic correlations...
July 16, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28691526/non-enhanced-versus-low-dose-contrast-enhanced-renal-magnetic-resonance-angiography-at-7-t-a-feasibility-study
#14
Anja Laader, Karsten Beiderwellen, Oliver Kraff, Stefan Maderwald, Mark E Ladd, Michael Forsting, Lale Umutlu
Background Considering the currently reported association between a repetitive application and cumulative dosage of Gadolinium (Gd)-based contrast agents and Gd-deposition in brain tissue as well as the risk for the advent of nephrogenic systemic fibrosis (NSF), techniques allowing for a dose reduction become an important key aspect aside from non-enhanced magnetic resonance angiography (MRA) techniques. Thus, this study was focused on the reduction and/or complete omission of contrast agent for renal MRA at 7T...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28687012/value-of-quantitative-magnetic-resonance-imaging-t1-relaxometry-in-predicting-contrast-enhancement-in-glioblastoma-patients
#15
Elke Hattingen, Andreas Müeller, Alina Jurcoane, Burkhard Mädler, Philip Ditter, Hans Schild, Ulrich Herrlinger, Martin Glas, Sied Kebir
The repetitive usage of gadolinium-based contrast agents (GBCA) is critical for magnetic resonance imaging (MRI) evaluation of tumor burden in glioblastoma patients. It is also a crucial tool for determination of radiographical response to treatment. GBCA injection, however, comes with a 2.4% rate of adverse events including life-threatening conditions such as nephrogenic systemic fibrosis (NSF). Moreover, GBCA have been shown to be deposited in brain tissue of patients even with an intact blood-brain barrier (BBB)...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28680623/nephrogenic-systemic-fibrosis
#16
Abhilash Koratala, Vikrampal Bhatti
Nephrogenic systemic fibrosis (NSF) is a fibrosing disorder seen in patients with renal dysfunction, commonly precipitated by administration of gadolinium contrast. There is no consistently successful treatment, but oral steroids, topical dovonex, extracorporeal photopheresis, and plasmapheresis have been tried [http://www.icnfdr.org/ Last accessed: 1/6/2017]. Avoidance of gadolinium in such patients is the key to prevention.
July 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28606036/scleroderma-like-disorders
#17
Amit Sharma
Scleroderma is a term used to describe diseases that involve hardening and tightening of the skin and the underlying subcutaneous connective tissue. It could be localized to skin and subcutaneous tissue, or may involve the internal organs too in systemic sclerosis. There are disorders that can cause hardening and tightening of skin and mimic scleroderma but are rarely associated with Raynaud phenomenon, sclerodactyly, and autoantibodies in the serum, features specific to scleroderma/systemic sclerosis. These are termed as "scleroderma variants" or "scleroderma like disorders"...
June 11, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28540211/delayed-enhancement-cardiac-computed-tomography-for-the-assessment-of-myocardial-infarction-from-bench-to-bedside
#18
REVIEW
Gaston A Rodriguez-Granillo
A large number of studies support the increasingly relevant prognostic value of the presence and extent of delayed enhancement (DE), a surrogate marker of fibrosis, in diverse etiologies. Gadolinium and iodinated based contrast agents share similar kinetics, thus leading to comparable myocardial characterization with cardiac magnetic resonance (CMR) and cardiac computed tomography (CT) at both first-pass perfusion and DE imaging. We review the available evidence of DE imaging for the assessment of myocardial infarction (MI) using cardiac CT (CTDE), from animal to clinical studies, and from 16-slice CT to dual-energy CT systems (DECT)...
April 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28501081/the-impact-of-excess-ligand-on-the-retention-of-nonionic-linear-gadolinium-based-contrast-agents-in-patients-with-various-levels-of-renal-dysfunction-a-review-and-simulation-analysis
#19
REVIEW
John P Prybylski, Michael Jay
The role of gadolinium (Gd)-based contrast agents (GBCAs) in the pathophysiology of nephrogenic systemic fibrosis (NSF) is now uncontested. Although the definitive mechanism has not been established, the association with weaker GBCA ligands and with reduced renal clearance supports a hypothesis that Gd release from the GBCAs is a key process in precipitating the disease. Prevention strategies often include the use of more stable GBCA ligands in patients with reduced kidney function, but animal models and some clinical data suggest that better patient outcomes can be achieved when excess ligand is administered with weaker GBCAs; this is particularly significant for OptiMARK, which contains a nonionic, linear ligand similar to gadodiamide, the active ingredient in Omniscan, but contains twice the amount of excess ligand...
May 2017: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/28501075/gadolinium-retention-and-toxicity-an-update
#20
REVIEW
Miguel Ramalho, Joana Ramalho, Lauren M Burke, Richard C Semelka
Until 2006, the main considerations regarding safety for all gadolinium-based contrast agents (GBCAs) were related to short-term adverse reactions. However, the administration of certain "high-risk" GBCAs to patients with renal failure resulted in multiple reported cases of nephrogenic systemic fibrosis. Findings have been reported regarding gadolinium deposition within the body and various reports of patients who report suffering from acute and chronic symptoms secondary to GBCA's exposure. At the present state of knowledge, it has been proved that gadolinium deposits also occur in the brain, irrespective of renal function and GBCAs stability class...
May 2017: Advances in Chronic Kidney Disease
keyword
keyword
35934
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"