keyword
MENU ▼
Read by QxMD icon Read
search

Poisons

keyword
https://www.readbyqxmd.com/read/29138589/clinical-characteristics-and-outcome-of-toxicity-from-amanita-mushroom-poisoning
#1
Satariya Trakulsrichai, Charuwan Sriapha, Achara Tongpoo, Umaporn Udomsubpayakul, Sunun Wongvisavakorn, Sahaphume Srisuma, Winai Wananukul
Objective: To describe and analyze the clinical characteristics and outcome of amatoxin poisoning cases. Methods: We performed a retrospective cohort study of amatoxin poisoning cases from Ramathibodi Poison Center Toxic Exposure Surveillance System, from May 2013 to August 2015. Results: There were 30 consultations with a total of 55 poisoning cases. Most cases were male and from the north-east region. Hepatitis, acute kidney injury, jaundice, and coagulopathy accounted for 74%, 46...
2017: International Journal of General Medicine
https://www.readbyqxmd.com/read/29138563/squarticles-as-the-nanoantidotes-to-sequester-the-overdosed-antidepressant-for-detoxification
#2
Chun-Han Chen, Tse-Hung Huang, Ahmed O Elzoghby, Pei-Wen Wang, Chia-Wen Chang, Jia-You Fang
The increasing death rate caused by drug overdose points to an urgent demand for the development of novel detoxification therapy. In an attempt to detoxify tricyclic antidepressant overdose, we prepared a lipid nanoemulsion, called squarticles, as the nanoantidote. Squalene was the major lipid matrix of the squarticles. Here, we present the animal study to investigate both the pharmacokinetic and pharmacodynamic effects of squarticles on amitriptyline intoxication. The anionic and cationic squarticles had average diameters of 97 and 122 nm, respectively...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29138448/antimicrobial-peptides-in-frog-poisons-constitute-a-molecular-toxin-delivery-system-against-predators
#3
Constantijn Raaymakers, Elin Verbrugghe, Sophie Hernot, Tom Hellebuyck, Cecilia Betti, Cindy Peleman, Myriam Claeys, Wim Bert, Vicky Caveliers, Steven Ballet, An Martel, Frank Pasmans, Kim Roelants
Animals using toxic peptides and proteins for predation or defense typically depend on specialized morphological structures, like fangs, spines, or a stinger, for effective intoxication. Here we show that amphibian poisons instead incorporate their own molecular system for toxin delivery to attacking predators. Skin-secreted peptides, generally considered part of the amphibian immune system, permeabilize oral epithelial tissue and enable fast access of cosecreted toxins to the predator's bloodstream and organs...
November 14, 2017: Nature Communications
https://www.readbyqxmd.com/read/29137869/morbidity-and-mortality-in-homeless-individuals-prisoners-sex-workers-and-individuals-with-substance-use-disorders-in-high-income-countries-a-systematic-review-and-meta-analysis
#4
Robert W Aldridge, Alistair Story, Stephen W Hwang, Merete Nordentoft, Serena A Luchenski, Greg Hartwell, Emily J Tweed, Dan Lewer, Srinivasa Vittal Katikireddi, Andrew C Hayward
BACKGROUND: Inclusion health focuses on people in extremely poor health due to poverty, marginalisation, and multimorbidity. We aimed to review morbidity and mortality data on four overlapping populations who experience considerable social exclusion: homeless populations, individuals with substance use disorders, sex workers, and imprisoned individuals. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, and the Cochrane Library for studies published between Jan 1, 2005, and Oct 1, 2015...
November 10, 2017: Lancet
https://www.readbyqxmd.com/read/29137861/renal-replacement-therapy-in-severe-phenobarbital-poisoning-another-brick-in-the-wall
#5
A Bedet, A Alestra, D Vodovar, A Mekontso Dessap, N de Prost
No abstract text is available yet for this article.
November 11, 2017: Medicina Intensiva
https://www.readbyqxmd.com/read/29137467/evaluation-of-serum-copper-level-in-naswar-smokeless-tobacco-addicts-using-flame-atomic-absorption-spectroscopy
#6
Asmat Ullah, Abad Khan, Zafar Iqbal, Ismail Khan
BACKGROUND: Substance abuse and its consequences are a matter of great concern in South-East Asian countries, especially Pakistan and Afghanistan. Due to contamination of Naswar with copper, or by any other physiological mechanism, there is a great chance of copper poisoning in addicts. Keeping in view the literature, there is no comparative study on serum copper levels (SCuL) in Naswar addicts. Therefore, it is very important to evaluate SCuL in this population. METHODS: The current study was performed in September 2016 where a total of 75 volunteers (selected from villages near the University of Peshawar, Pakistan) were grouped as Naswar addicts (n = 45) and the control group (n = 30)...
October 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29137047/massive-neonatal-intracranial-hemorrhage-caused-by-bromadiolone-a-case-report
#7
Mingsheng Ma, Mengqi Zhang, Xiaoyan Tang, Zhenghong Li
RATIONALE: Bromadiolone, often called a super-warfarin, is a potent rodenticide with long half-life. Skin and mucosal bleeding is the most common clinical manifestations of its intoxication. Bromadiolone intoxications in adults and children have been reported, but this phenomenon is rarely seen in fetuses. This paper presents a case of neonate with massive intracranial hemorrhage mediated by bromadiolone intoxication, highlighting that the bromadiolone is potentially lethal to the fetus...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29135964/the-killer-of-socrates-coniine-and-related-alkaloids-in-the-plant-kingdom
#8
REVIEW
Hannu Hotti, Heiko Rischer
Coniine, a polyketide-derived alkaloid, is poisonous to humans and animals. It is a nicotinic acetylcholine receptor antagonist, which leads to inhibition of the nervous system, eventually causing death by suffocation in mammals. Coniine's most famous victim is Socrates who was sentenced to death by poison chalice containing poison hemlock in 399 BC. In chemistry, coniine holds two historical records: It is the first alkaloid the chemical structure of which was established (in 1881), and that was chemically synthesized (in 1886)...
November 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29135913/management-of-ciguatoxin-risk-in-eastern-australia
#9
Hazel Farrell, Shauna A Murray, Anthony Zammit, Alan W Edwards
Between 2014 and 2016, five cases of ciguatera fish poisoning (CFP), involving twenty four individuals, were linked to Spanish Mackerel (Scomberomorus commerson) caught in the coastal waters of the state of New South Wales (NSW) on the east coast of Australia. Previously, documented cases of CFP in NSW were few, and primarily linked to fish imported from other regions. Since 2015, thirteen individuals were affected across four additional CFP cases in NSW, linked to fish imported from tropical locations. The apparent increase in CFP in NSW from locally sourced catch, combined with the risk of CFP from imported fish, has highlighted several considerations that should be incorporated into risk management strategies to minimize CFP exposure for seafood consumers...
November 14, 2017: Toxins
https://www.readbyqxmd.com/read/29135905/unsuccessful-suicide-attempt-with-tiapride
#10
Sylvain Couderc, Hervé Mourou, Caroline Monchaud, Franck Saint-Marcoux
To the best of our knowledge, no case has been published in the literature that reports an overdose of tiapride, either alone or in combination with other drugs. We report a self-poisoning case in an 18-year-old girl, with approximately 10 times the usual daily dose (ie, 2.5 g). Although the blood concentration was 20/30-fold higher than usually observed after therapeutic drug intakes (17,300 mcg/L), the patient remained almost asymptomatic.
December 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29134971/detection-of-dna-fragmentation-in-liver-of-goats-exposed-to-lead-poisoning-in-bagega-district-of-zamfara-state-nigeria
#11
A T Jubril, O A Fagbohun, A A Adekola
The ubiquitous presence of lead (Pb) and its release by anthropogenic activities has remained a majorenvironmental pollution risk to both humans and animals. Lead toxicity has been associated with different systemic toxicitiesand biochemical impacts (such as oxidative stress and DNA damaging effects) with dire health consequences. In Nigeria,the health problem associated with lead toxicity has been overwhelming in the Bagega District of Zamfara State whereartisanal gold mining has resulted in widespread environmental lead contamination...
June 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29134498/vasoplegic-shock-treated-with-methylene-blue-complicated-by-severe-serotonin-syndrome
#12
Betty S Chan, Therese Becker, Angela L Chiew, Ahmed M Abdalla, Tom A Robertson, Xin Liu, Michael S Roberts, Nicholas A Buckley
INTRODUCTION: Management of severe vasoplegic shock in overdose can be very challenging. We describe a case of severe refractory vasodilatory shock in poisoning where methylene blue (MB) was used with success. However, the patient subsequently developed severe Serotonin Syndrome (SS) as a result of an interaction between serotonergic drugs and MB. CASE REPORT: A 15-year-old male developed severe vasoplegic shock 1.5 hours after overdosing on several different medications including quetiapine slow release, quetiapine immediate release, desvenlafaxine slow release, venlafaxine, amlodipine, ramipril, fluoxetine, promethazine and lithium...
November 13, 2017: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/29133072/treatment-of-pediatric-black-widow-spider-envenomation-a-national-poison-center-s-experience
#13
Miguel Glatstein, Gary Carbell, Dennis Scolnik, Ayelet Rimon, Christopher Hoyte
BACKGROUND: Black widow species (Latrodectus species) envenomation can produce a syndrome characterized by painful muscle rigidity and autonomic disturbances. Symptoms tend to be more severe in young children and adults. We describe black widow spider exposures and treatment in the pediatric age group, and investigate reasons for not using antivenom in severe cases. METHODS: All black widow exposures reported to the Rocky Mountain Poison Center between January 1, 2012, and December 31, 2015, were reviewed...
November 6, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29132247/management-of-a-rare-case-with-severe-hydrofluoric-acid-burns-important-roles-of-neutralizers-and-continuous-renal-replacement-therapy
#14
Yuanhai Zhang, Xingang Wang, Yuezhen Liu, Xinhua Jiang, Chunjiang Ye, Liangfang Ni, Liping Zhang, Jianfen Zhang, Bin Xu, Chunmao Han
Hydrofluoric acid (HF), a dangerous inorganic acid, is widely used in various industries and in daily life. Chemical burns caused by HF exposure occur more frequently in some regions worldwide. It has been reported that some cases with HF burns can be lethal due to the hypertoxicity of HF. In this article, we present a case of a 24-year-old worker who suffered HF burns by 53% HF solution to his face, neck, and nasal cavity. This patient quickly developed electrolyte disturbance, that is, hypocalcemia, and hypopotassemia, and myocardial injury after exposure...
November 1, 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/29132030/capture-and-detection-of-staphylococcus-aureus-with-dual-labeled-aptamers-to-cell-surface-components
#15
Shylaja Ramlal, Bhairab Mondal, Padma Sudharani Lavu, Bhavanashri N, Joseph Kingston
In the present study, a high throughput whole cell SELEX method has been applied successfully in selecting specific aptamers against whole cells of Staphylococcus aureus, a potent food poisoning bacterium. A total ten rounds of SELEX and three rounds of intermittent counter SELEX, was performed to obtain specific aptamers. Obtained oligonucleotide pool were cloned, sequenced and then grouped into different families based on their primary sequence homology and secondary structure similarity. FITC labeled sequences from different families were selected for further characterization via flow cytometry analysis...
November 7, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29131869/assessing-current-temporal-and-space-time-anomalies-of-disease-incidence
#16
Chih-Chieh Wu, Chien-Hsiun Chen, Sanjay Shete
Approaches used to early and accurately characterize epidemiologic patterns of disease incidence in a temporal and spatial series are becoming increasingly important. Cluster tests are generally designed for retrospective detection of epidemiologic anomalies in a temporal or space-time series. Timely identification of anomalies of disease or poisoning incidence during ongoing surveillance or an outbreak requires the use of sensitive statistical methods that recognize an incidence pattern at the time of occurrence...
2017: PloS One
https://www.readbyqxmd.com/read/29129815/biological-effects-of-adipocytes-in-sulfur-mustard-induced-toxicity
#17
Hua Xu, Zhongcai Gao, Peng Wang, Bin Xu, Yajiao Zhang, Long Long, Cheng Zong, Lei Guo, Weijian Jiang, Qinong Ye, Lili Wang, Jianwei Xie
Sulphur mustard (2,2'-dichloroethyl sulfide; SM) is a vesicant chemical warfare agent whose mechanism of acute or chronic action is not known with any certainty and to date there is no effective antidote. SM accumulation in adipose tissue (AT) has been originally verified in our previous study. To evaluate the biological effect caused by the presence of abundant SM in adipocyte and assess the biological role of AT in SM poisoning, in vitro and in vivo experiments were performed. High content analysis revealed multi-cytotoxicity in SM exposed cells in a time and dose dependent manner, and adipocytes showed a relative moderate damage compared with non-adipocytes...
November 9, 2017: Toxicology
https://www.readbyqxmd.com/read/29129799/post-exposure-treatment-with-the-oxime-rs194b-rapidly-reactivates-and-reverses-advanced-symptoms-of-lethal-inhaled-paraoxon-in-macaques
#18
Yvonne J Rosenberg, Jerry Wang, Tara Ooms, Narayanan Rajendran, Lingjun Mao, Xiaoming Jiang, Jonathan Lees, Lori Urban, Jeremiah Romper, Yadire Sepulveda, Yan-Jye Shyong, Palmer Taylor
Fatalities from organophosphate (OP) insecticide result from both occupational and deliberate exposure; significantly impacting human health. Like nerve agents, insecticides are neurotoxins which target and inhibit acetylcholinesterases (AChE) in central and peripheral synapses in the cholinergic nervous system. Post-exposure therapeutic countermeasures generally include administration of atropine with a pyridinium aldoximes e.g. pralidoxime, to reactivate the OP-inhibited AChE. However, commonly used oximes inefficiently cross the blood brain barrier and are rapidly cleared and their benefit is debated...
November 9, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/29129798/the-efficacy-of-hi-6-dms-in-a-sustained-infusion-against-percutaneous-vx-poisoning-in-the-guinea-pig
#19
C Whitmore, A R Cook, T Mann, M E Price, E Emery, N Roughley, D Flint, S Stubbs, S J Armstrong, H Rice, J E H Tattersall
Post-exposure nerve agent treatment usually includes administration of an oxime, which acts to restore function of the enzyme acetylcholinesterase (AChE). For immediate treatment of military personnel, this is usually administered with an autoinjector device, or devices containing the oxime such as pralidoxime, atropine and diazepam. In addition to the autoinjector, it is likely that personnel exposed to nerve agents, particularly by the percutaneous route, will require further treatment at medical facilities...
November 9, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/29129117/calls-to-poison-centers-for-hookah-smoking-exposures
#20
Sandra S Retzky, Henry A Spiller, Priscilla Callahan-Lyon
Over the past decade, smoking behaviors have changed in the US. Hookah or waterpipe smoking is increasing, especially among youth and young adults. Social media sites describe the "hookah high" or "buzz", which may be related to nicotine, carbon monoxide, or other inhalants in hookah smoke. Most important is the risk of carbon monoxide poisoning. Case reports include a high number of victims presenting with loss of consciousness from either syncope or seizures. Anaphylaxis and a very rare respiratory hypersensitivity reaction, acute eosinophilic pneumonia, have also been reported from hookah smoking in previously healthy young adults...
November 13, 2017: Clinical Toxicology
keyword
keyword
35927
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"