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https://www.readbyqxmd.com/read/28437641/human-neuronal-cell-based-assay-a-new-in-vitro-model-for-toxicity-evaluation-of-ciguatoxin
#1
Teresa Coccini, Francesca Caloni, Uliana De Simone
Ciguatoxins (CTXs) are emerging marine neurotoxins representing the main cause of ciguatera fish poisoning, an intoxication syndrome which configures a health emergency and constitutes an evolving issue constantly changing due to new vectors and derivatives of CTXs, as well as their presence in new non-endemic areas. The study applied the neuroblastoma cell model of human origin (SH-SY5Y) to evaluate species-specific mechanistic information on CTX toxicity. Metabolic functionality, cell morphology, cytosolic Ca(2+)i responses, neuronal cell growth and proliferation were assessed after short- (4-24h) and long-term exposure (10days) to P-CTX-3C...
April 14, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28435437/lower-suicide-intention-in-patients-with-personality-disorders-admitted-for-deliberate-self-poisoning-than-in-patients-with-other-diagnoses
#2
T K Grimholt, D Jacobsen, O R Haavet, Ø Ekeberg
BACKGROUND: People with deliberate self-poisoning and personality disorders are in increased risk for suicide. Intention and psychiatric features are important factors in a psychiatric evaluation and for planning aftercare. METHODS: Patients admitted to medical departments after deliberate self-poisoning were studied (n = 117). Patients with personality disorder according to (ICD-10, F.60-69) were compared to patients with affective disorders, substance use disorders, and unknown psychiatric diagnosis on Beck Suicide Intention Scale (SIS), Beck Suicide Ideation Scale (BSI), Beck Hopelessness Scale (BHS), and Beck Depression Inventory (BDI)...
2017: Annals of General Psychiatry
https://www.readbyqxmd.com/read/28432527/effects-of-agaricus-blazei-murill-polysaccharide-on-cadmium-poisoning-on-the-mda5-signaling-pathway-and-antioxidant-function-of-chicken-peripheral-blood-lymphocytes
#3
Ai Lv, Ming Ge, Xuequan Hu, Wenjing Liu, Guangxing Li, Ruili Zhang
This experimental study investigated the effect of Agaricus blazei Murill polysaccharide (ABP) on cadmium (Cd) poisoning on the melanoma differentiation-associated gene 5 (MDA5) signaling pathway and antioxidant function of peripheral blood lymphocytes (PBLs) in chickens. The experiments were divided into four groups: 7-day-old chickens with normal saline (0.2 mL single/day), Cd (140 mg/kg), ABP (30 mg/mL, 0.2 mL single/day), and Cd + ABP(140 mg/kg/day + 0.2 mL ABP). Peripheral blood was collected on the 20th, 40th, and 60th days for each group, and PBLs were separated...
April 21, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28428704/lead-poisoning-due-to-herbal-medications
#4
Shailja Chambial, Pankaj Bhardwaj, Abbas Ali Mahdi, Praveen Sharma
Lead ranks as one of the most serious environmental poisons all over the world amongst toxic heavy metals with no known biological function useful for the human body. A case of lead toxicity due to consumption of herbal medicine is being discussed. The case presented with gastrointestinal complaints and history of intake of herbal medicines for diabetes control for past 8 months. The analysis of the powdered herbal medicine procured from ayurveda practitioner was found to have high content of lead responsible for the lead toxicity...
June 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28427969/hyperbaric-oxygen-therapy-is-associated-with-lower-short-and-long-term-mortality-in-patients-with-carbon-monoxide-poisoning
#5
Chien-Cheng Huang, Chung-Han Ho, Yi-Chen Chen, Hung-Jung Lin, Chien-Chin Hsu, Jhi-Joung Wang, Shih-Bin Su, How-Ran Guo
BACKGROUND: To date, there has been no consensus about the effect of hyperbaric oxygen therapy (HBOT) on the mortality of patients with carbon monoxide poisoning (COP). This retrospective nationwide population-based cohort study from Taiwan was conducted to clarify this issue. METHODS: Using the Nationwide Poisoning Database, we identified 25,737 COP patients diagnosed between 1999 and 2012, including 7,278 patients who received HBOT and 18,459 patients who did not...
April 17, 2017: Chest
https://www.readbyqxmd.com/read/28427557/oxidative-stress-love-and-hate-history-in-central-nervous-system
#6
Genaro Gabriel Ortiz, Fermín P Pacheco Moisés, Mario Mireles-Ramírez, Luis J Flores-Alvarado, Héctor González-Usigli, Víctor J Sánchez-González, Angélica L Sánchez-López, Lorenzo Sánchez-Romero, Eduardo I Díaz-Barba, J Francisco Santoscoy-Gutiérrez, Paloma Rivero-Moragrega
Molecular oxygen is essential for aerobic organisms in order to synthesize large amounts of energy during the process of oxidative phosphorylation and it is harnessed in the form of adenosine triphosphate, the chemical energy of the cell. Oxygen is toxic for anaerobic organisms but it is also less obvious that oxygen is poisonous to aerobic organisms at higher concentrations of oxygen. For instance, oxygen toxicity is a condition resulting from the harmful effects of breathing molecular oxygen at increased partial pressures...
2017: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/28426075/functionalized-vinylsilanes-via-highly-efficient-and-recyclable-pt-nanoparticle-catalysed-hydrosilylation-of-alkynes
#7
Bhanu P S Chauhan, Alok Sarkar
A mild, selective and facile synthesis of vinylsilanes via a recyclable platinum nanoparticle catalysed hydrosilylation of alkynes is reported. Various functionalized alkynes are selectively hydrosilylated to furnish functional β-E vinylsilanes in high yields. The catalytic effectiveness, ease of catalyst recovery and recyclability of the polysiloxane stabilized Pt-nanoparticle catalyst are the major achievements of this work. Detailed in situ characterization using Electron Microscopy and controlled poisoning experiments supports the participation of Pt-nanoparticles as active catalysts...
April 20, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28426049/a-pt-co3o4-cd-electrocatalyst-with-enhanced-electrocatalytic-performance-and-resistance-to-co-poisoning-achieved-by-carbon-dots-and-co3o4-for-direct-methanol-fuel-cells
#8
Yue Sun, Yunjie Zhou, Cheng Zhu, Lulu Hu, Mumei Han, Aoqi Wang, Hui Huang, Yang Liu, Zhenhui Kang
Highly efficient electrocatalysts remain huge challenges in direct methanol fuel cells (DMFCs). Here, a Pt-Co3O4-CDs/C composite was fabricated as an anode electrocatalyst with low Pt content (12 wt%) by using carbon dots (CDs) and Co3O4 nanoparticles as building blocks. The Pt-Co3O4-CDs/C composite catalyst shows a significantly enhanced electrocatalytic activity (1393.3 mA mg(-1) Pt), durability (over 4000 s) and CO-poisoning tolerance. The superior catalytic activity should be attributed to the synergistic effect of CDs, Pt and Co3O4...
April 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28425705/facile-aqueous-phase-synthesis-of-ptau-bi2o3-hybrid-catalyst-for-efficient-electro-oxidation-of-ethanol
#9
Sumanta Sarkar, Rajkumar Jana, Hiranmayee Vadlamani, Swetha Ramani, Dundappa Mumbaraddi, Sebastian C Peter
In this work, we present a facile aqueous phase synthesis of a hybrid catalyst consists of PtAu alloy supported on Bi2O3 microspheres. Multistep reduction of HAuCl4 and K2PtCl4 salts on Bi2O3 and subsequent annealing leads to the formation of this hybrid catalyst. To the best of our knowledge, this is the first report of using Bi2O3 as a catalyst support in Fuel cell applications. The material was characterized by powder X-ray diffraction and various microscopic techniques. This composite showed remarkable activity as well as stability towards the electro-oxidation of ethanol in comparison to commercially available Pt/C...
April 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28425670/electroencephalographic-patterns-of-lithium-poisoning-a-study-of-the-effect-concentration-relationships-in-the-rat
#10
Anne-Sophie Hanak, Isabelle Malissin, Joël Poupon, Patricia Risède, Lucie Chevillard, Bruno Mégarbane
OBJECTIVES: Lithium overdose may result in encephalopathy and electroencephalographic abnormalities. Three poisoning patterns have been identified based on the ingested dose, previous treatment duration and renal function. Whether the severity of lithium-induced encephalopathy depends on the poisoning pattern has not been established. We designed a rat study to investigate lithium-induced encephalopathy and correlate its severity to plasma, erythrocyte, cerebrospinal fluid and brain lithium concentrations previously determined in rat models mimicking human poisoning patterns...
April 20, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28425396/development-and-single-laboratory-validation-of-a-liquid-chromatography-tandem-mass-spectrometry-method-for-quantitation-of-tetrodotoxin-in-mussels-and-oysters
#11
Andrew D Turner, Michael J Boundy, Monika Dhanji Rapkova
In recent years, evidence has grown for the presence of tetrodotoxin (TTX) in bivalve mollusks, leading to the potential for consumers of contaminated products to be affected by Tetrodotoxin Shellfish Poisoning (TSP). A single-laboratory validation was conducted for the hydrophilic interaction LC (HILIC) tandem MS (MS/MS) analysis of TTX in common mussels and Pacific oysters-the bivalve species that have been found to contain TTXs in the United Kingdom in recent years. The method consists of a single-step dispersive extraction in 1% acetic acid, followed by a carbon SPE cleanup step before dilution and instrumental analysis...
April 20, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28425352/overdose-in-young-children-treated-with-anti-reflux-medications-poisons-enquiry-evidence-of-excess-10-fold-dosing-errors-with-ranitidine
#12
C Crawford, M Anderson, G Cooper, G Jackson, J Thompson, A Vale, Shl Thomas, M Eddleston, D N Bateman
BACKGROUND: Accidental drug overdose is a common problem in young children. We examined the influence of formulation and dose in enquiries for different gastro-oesophageal reflux disease treatments in children under 5 years to the UK's National Poisons Information Service. METHODS: Overdose characteristics with ranitidine, omeprazole or domperidone were compared with those of metoclopramide and the H-1 antagonist chlorphenamine, for the period 1 July 2007 to 30 June 2015...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28425351/metabolic-changes-in-methomyl-poisoned-rats-treated-by-vitamin-e
#13
J Weng, B Cai, J Chen, B Chen, H Wu, C Wen, F Sun, L Hu, C Chen, X Wang, Z Wang
In this study, we developed a serum and urine metabolomic method based on gas chromatography-mass spectrometry (GC-MS) combination with biomedical results to evaluate the effect of vitamin E treatment on methomyl poisoning rats. The rats were divided into three groups: the control group, methomyl poisoning group, and vitamin E treatment group. Partial least squares discriminate analysis (PLS-DA) showed that methomyl poisoning induced metabolic perturbations. Compared to the control group, based on the urinary metabolomics data, the level of ribitol, l-proline, xylitol, hydrocinnamic acid, 11-cis-octadecenoic acid, octadecanoic acid, and hexadecanoic acid of methomyl poisoning group increased, while the level of 2,3,4-trihydroxybutyric acid, ethanimidic acid, pantothenic acid, and retinoic acid decreased...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28425262/copeptin-levels-in-carbon-monoxide-poisoning
#14
Güler Irem, Yunsur Çevik, Ahmet Turgut Keskin, Emine Emektar, Osman Lütfi Demirci, Tuba Şafak, Gülşah Çikrikçi Işik, Kadir Okhan Akin
BACKGROUND/AIM: The aim of this study is to identify the copeptin levels in patients presenting with carbon monoxide (CO) poisoning to the emergency department and to investigate its correlation with the neurological effects. MATERIALS AND METHODS: The study group consisted of patients presenting with CO poisoning and carboxyhemoglobin levels >10%. Blood samples for copeptin levels were obtained twice, first at presentation then at the fourth hour of observation...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28424960/selenium-for-the-mitigation-of-toxicity-induced-by-lead-in-chicken-testes-through-regulating-mrna-expressions-of-hsps-and-selenoproteins
#15
He Huang, Yan Wang, Yang An, Yaguang Tian, Shu Li, Xiaohua Teng
Lead (Pb) is a toxic element and environmental pollutant. Pb toxicity and antagonistic effect of selenium (Se) on Pb have been deeply studied in mammals. The testis is one of the target organs of Pb in birds. The aim of this study was to investigate the mitigating effect of Se on Pb toxicity in chicken testes by determining messenger RNA (mRNA) expressions of 5 heat shock proteins (HSPs) and 25 selenoproteins. Sixty male chickens (7-day-old) were randomly divided into the control group, the Se group, the Pb group, and the Pb + Se group, and were fed for 90 days...
April 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28424456/paraquat-poisoning-induced-pulmonary-epithelial-mesenchymal-transition-through-notch1-pathway
#16
Tiegang Li, Xiangming Yang, Shiyu Xin, Yan Cao, Nana Wang
Progressive pulmonary fibrosis is the most characteristic feature of subacute PQ poisoning. Epithelial-to-mesenchymal transition (EMT) is reported to be involved in the pulmonary fibrosis after PQ exposure. Recent evidence suggested Notch signaling is required for EMT. In this study, we investigated whether Notch1 and TGF-β1/Smad3 signaling was involved in EMT caused by PQ. It is demonstrated that A549 cells underwent EMT after treated with PQ at dose of 300 μmol/L for 6 days, charactered by increasing expression of mesenchymal marker α-SMA and decreasing expression of epithelial marker E-cadherin...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28421977/-a-woman-with-pink-urine-and-a-pink-skin
#17
J A Versteeg, G A M van der Nat
A 48-year-old woman with fire-related inhalation injury had pink urine and a pink skin. This was caused by hydroxocobalamin, which was used to treat cyanide poisoning.
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28421842/the-management-of-ventricular-dysrhythmia-in-aconite-poisoning
#18
James M Coulson, Thomas M Caparrotta, John P Thompson
INTRODUCTION: Aconite poisoning is relatively rare but is frequently complicated by ventricular dysrhythmias, which may be fatal. Molecular basis of aconite alkaloid ventricular arrhythmogenicity: Aconite exerts its toxic effects due to the presence of an admixture of alkaloids present in all parts of the plant. The major target of these aconite alkaloids is the fast voltage-gates sodium channel, where they cause persistent activation. This blockade of the channel in the activated state promotes automaticity within the ventricular myocardium and the generation of ventricular arrhythmias...
June 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28421837/pediatric-ingestion-of-vilazodone-compared-to-other-selective-serotonin-reuptake-inhibitor-medications
#19
Jason L Russell, Henry A Spiller, Thiphalak Chounthirath, Marcel J Casavant
BACKGROUND: Unintentional ingestion of selective serotonin reuptake inhibitor (SSRI) medications is common amongst children <6 years of age. Current evidence-based management guidelines are based on a low incidence of significant medical outcomes in these children. OBJECTIVE: To describe and compare outcomes of pediatric exposures to vilazodone with other SSRIs. METHODS: A retrospective observational case series analysis of both single and polysubstance SSRI exposures amongst children <6 years old reported to the National Poison Data System (NPDS)...
June 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28421827/pediatric-nandina-domestica-ingestions-reported-to-poison-centers
#20
M B Forrester
Nandina domestica is grown as an ornamental plant in the United States but has also been reported as an invasive plant in a number of states. Parts of the plant, particularly the berries, contain cyanogenic glycosides that convert to hydrogen cyanide when ingested. This investigation characterized N. domestica ingestions involving patients of age 5 years and less reported to Texas poison centers during 2000-2015. There were 875 total N. domestica ingestions. A seasonal pattern was observed with the highest proportion of ingestions occurring in March (18...
January 1, 2017: Human & Experimental Toxicology
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