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Kerem Bingol, Lei Bruschweiler-Li, Da-Wei Li, Rafael Brüschweiler
A customized metabolomics NMR database, termed (1)H((13)C)-TOCCATA, is introduced, which contains complete (1)H and (13)C chemical shift information on individual spin systems and isomeric states of common metabolites. Since this information directly corresponds to cross sections of 2D (1)H-(1)H TOCSY and 2D (13)C-(1)H HSQC-TOCSY spectra, it allows the straightforward and unambiguous identification of metabolites of complex metabolic mixtures at (13)C natural abundance from these types of experiments. The (1)H((13)C)-TOCCATA database, which is complementary to the previously introduced TOCCATA database for the analysis of uniformly (13)C-labeled compounds, currently contains 455 metabolites, and it can be used through a publicly accessible web portal...
June 3, 2014: Analytical Chemistry
Gianpiero Marconi, Roberta Pace, Alessandra Traini, Lorenzo Raggi, Stanley Lutts, Marialuisa Chiusano, Marcello Guiducci, Mario Falcinelli, Paolo Benincasa, Emidio Albertini
Excessive soil salinity is a major ecological and agronomical problem, the adverse effects of which are becoming a serious issue in regions where saline water is used for irrigation. Plants can employ regulatory strategies, such as DNA methylation, to enable relatively rapid adaptation to new conditions. In this regard, cytosine methylation might play an integral role in the regulation of gene expression at both the transcriptional and post-transcriptional levels. Rapeseed, which is the most important oilseed crop in Europe, is classified as being tolerant of salinity, although cultivars can vary substantially in their levels of tolerance...
2013: PloS One
Kazutaka Shinozuka, Haruka Ono, Shigeru Watanabe
This paper investigated whether music has reinforcing and discriminative stimulus properties in goldfish. Experiment 1 examined the discriminative stimulus properties of music. The subjects were successfully trained to discriminate between two pieces of music--Toccata and Fugue in D minor (BWV 565) by J. S. Bach and The Rite of Spring by I. Stravinsky. Experiment 2 examined the reinforcing properties of sounds, including BWV 565 and The Rite of Spring. We developed an apparatus for measuring spontaneous sound preference in goldfish...
October 2013: Behavioural Processes
Kerem Bingol, Fengli Zhang, Lei Bruschweiler-Li, Rafael Brüschweiler
A customized metabolomics NMR database, TOCCATA, is introduced, which uses (13)C chemical shift information for the reliable identification of metabolites, their spin systems, and isomeric states. TOCCATA, whose information was derived from the BMRB and HMDB databases and the literature, currently contains 463 compounds and 801 spin systems, and it can be used through a publicly accessible web server. TOCCATA allows the identification of metabolites in the submillimolar concentration range from (13)C-(13)C total correlation spectroscopy experiments of complex mixtures, which is demonstrated for an Escherichia coli cell lysate, a carbohydrate mixture, and an amino acid mixture, all of which were uniformly (13)C-labeled...
November 6, 2012: Analytical Chemistry
Vivek Y Reddy, Dipen Shah, Josef Kautzner, Boris Schmidt, Nadir Saoudi, Claudia Herrera, Pierre Jaïs, Gerhard Hindricks, Petr Peichl, Aude Yulzari, Hendrik Lambert, Petr Neuzil, Andrea Natale, Karl-Heinz Kuck
BACKGROUND: The clinical efficacy of catheter ablation of paroxysmal atrial fibrillation (AF) remains limited by difficulty in achieving durable pulmonary vein isolation (PVI). Suboptimal catheter tip-to-tissue contact force (CF) during lesion delivery is believed to reduce clinical efficacy. OBJECTIVE: To determine the relationship between catheter CF during irrigated catheter ablation for AF and clinical recurrences during follow-up. METHODS: Thirty-two patients with paroxysmal AF underwent PVI by using a radiofrequency ablation catheter with a CF sensor integrated at its tip, and they were followed for 12 months...
November 2012: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Thomas L Diepgen, Egon Pfarr, Thomas Zimmermann
This non-interventional observational open study (TOCCATA, sponsored by Basilea Pharmaceutica Germany) investigated the use of alitretinoin to treat chronic hand eczema under daily "real life" medical practice conditions in Germany. A total of 349 dermatologists through-out Germany enrolled 680 adult patients with chronic hand eczema. Patients were prescribed and treated with alitretinoin in accordance with the summary of product characteristics. The maximum observation duration was 24 weeks, with efficacy and safety parameters evaluated every 4 weeks...
May 2012: Acta Dermato-venereologica
Karl-Heinz Kuck, Vivek Y Reddy, Boris Schmidt, Andrea Natale, Petr Neuzil, Nadir Saoudi, Josef Kautzner, Claudia Herrera, Gerhard Hindricks, Pierre Jaïs, Hiroshi Nakagawa, Hendrik Lambert, Dipen C Shah
OBJECTIVES: The aim of this multicenter study was to evaluate the device- and procedure-related safety of a novel force-sensing radiofrequency (RF) ablation catheter capable of measuring the real-time contact force (CF) and to present CF data and its possible implications on patient safety. BACKGROUND: The clinical outcome of RF ablation for the treatment of cardiac arrhythmias may be affected by the CF between the catheter tip and the tissue. Insufficient CF may result in an ineffective lesion, whereas excessive CF may result in complications...
January 2012: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Virginie Fontanier, Vincent Farines, Joël Albet, Sylvie Baig, Jacques Molinier
Ozonation and catalytic ozonation (TOCCATA process) were used as tertiary treatments of wastewaters from three different pulp and paper mills. Laboratory batch experiments were conducted to assess the efficiency of each oxidation system for removal of organic matter. The investigations measured ozone consumption rate, variations in chemical oxygen demand (COD), total organic carbon (TOC), suspended solids (SS) and molecular weight distribution with contact time. For conventional ozonation, ozone consumption rate was dependent on the nature of the effluent...
January 2006: Water Research
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