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Ocular melanoma

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https://www.readbyqxmd.com/read/28231293/photoacoustic-imaging-features-of-intraocular-tumors-retinoblastoma-and-uveal-melanoma
#1
Guan Xu, Yafang Xue, Zeynep Gürsel Özkurt, Naziha Slimani, Zizhong Hu, Xueding Wang, Kewen Xia, Teng Ma, Qifa Zhou, Hakan Demirci
The purpose of this study is to examine the capability of photoacoustic (PA) imaging (PAI) in assessing the unique molecular and architectural features in ocular tumors. A real-time PA and ultrasonography (US) parallel imaging system based on a research US platform was developed to examine retinoblastoma in mice in vivo and human retinoblastoma and uveal melanoma ex vivo. PA signals were generated by optical illumination at 720, 750, 800, 850, 900 and 950 nm delivered through a fiber optical bundle. The optical absorption spectra of the tumors were derived from the PA images...
2017: PloS One
https://www.readbyqxmd.com/read/28217870/adult-ocular-medulloepithelioma-diagnosed-by-transscleral-fine-needle-aspiration-a-case-report
#2
Amir Mahdjoubi, Nathalie Cassoux, Christine Levy-Gabriel, Laurence Desjardins, Jan Klos, Martial Caly, Tatjana Vlajnic, Sophie Gardrat, Jerzy Klijanienko
Ocular medulloepithelioma (ME) is a rare congenital tumor which occurs usually during childhood but is also reported in adults. They have seen an intraocular tumor in an 89 years-old female with a history of small cell lung carcinoma. Transscleral fine needle aspiration was performed. Aspirates were rich and composed of two distinctive populations of cells. The first consisted of epithelioid large cohesive cells with rare rosettes. Nuclei were oval and chromatin was delicate with small nucleoli. The second population consisted of smaller and dispersed cells with regular nuclei and dusty chromatin...
February 20, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28178721/chemosaturation-with-percutaneous-hepatic-perfusion-in-unresectable-hepatic-metastases
#3
REVIEW
Evan S Glazer, Jonathan S Zager
BACKGROUND: In patients with hepatic metastases from solid-organ malignancies, surgical resection may be a potentially curative option, but it is not possible in most cases. Chemosaturation with percutaneous hepatic perfusion was developed for the management of unresectable metastases to the liver. METHODS: Relevant medical literature was summarized with regard to the outcomes and limitations of chemosaturation with percutaneous hepatic perfusion. RESULTS: Six articles were identified that contained data on 91 individuals who received chemosaturation with percutaneous hepatic perfusion...
January 2017: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/28168935/reproducibility-of-a-noninvasive-system-for-eye-positioning-and-monitoring-in-stereotactic-radiotherapy-of-ocular-melanoma
#4
Omar Iskanderani, Dominique Béliveau-Nadeau, Robert Doucet, Geneviève Coulombe, Deborah Pascale, David Roberge
PURPOSE: Our preferred treatment for juxtapapillary choroidal melanoma is stereotactic radiotherapy. We aim to describe our immobilization system and quantify its reproducibility. MATERIALS AND METHODS: Patients were identified in our radiosurgery database. Patients were imaged at computed tomography simulator with an in-house system which allows visual monitoring of the eye as the patient fixates a small target. All patients were reimaged at least once prior to and/or during radiotherapy...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28161431/dosimetric-and-radiobiologic-comparison-of-103-pd-coms-plaque-brachytherapy-and-gamma-knife-radiosurgery-for-choroidal-melanoma
#5
Daniel Gorovets, Nolan L Gagne, Christopher S Melhus
PURPOSE: Plaque brachytherapy (BT) and Gamma Knife radiosurgery (GKRS) are highly conformal treatment options for choroidal melanoma. This study objectively compares physical dose and biologically effective dose (BED) distributions for these two modalities. METHODS AND MATERIALS: Tumor and organ-at-risk (OAR) dose distributions from a CT-defined reference right eye were compared between (103)Pd COMS (Collaborative Ocular Melanoma Study Group) plaques delivering 70 Gy (plaque heterogeneity corrected) over 120 h to the tumor apex and GKRS plans delivering 22 Gy to the 40% isodose line for a representative sample of clinically relevant choroidal melanoma locations and sizes...
February 1, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28159380/cytogenetic-abnormalities-in-uveal-melanoma-based-on-tumor-features-and-size-in-1059-patients-the-2016-w-richard-green-lecture
#6
Carol L Shields, Emil Anthony T Say, Murat Hasanreisoglu, Jarin Saktanasate, Brendan M Lawson, Jeffrey E Landy, Anjali U Badami, Meera D Sivalingam, Arman Mashayekhi, Jerry A Shields, Arupa Ganguly
PURPOSE: To determine the risks for altered cytogenetic profile based on melanoma features and size. DESIGN: Retrospective case series. PARTICIPANTS: A total of 1059 patients with uveal melanoma. METHODS: Fine-needle aspiration biopsy (FNAB) of tumor for DNA amplification and whole genome array-based assay. MAIN OUTCOME MEASURES: Risk for cytogenetic abnormalities based on features and size: small (≤3 mm thickness), medium (>3-<8 mm), and large (≥8 mm)...
January 31, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28141766/choroidal-nevus-a-review-of-prevalence-features-genetics-risks-and-outcomes
#7
Jason L Chien, Kareem Sioufi, Thamolwan Surakiatchanukul, Jerry A Shields, Carol L Shields
PURPOSE OF REVIEW: To review the prevalence, clinical features, imaging findings, cytogenetics, and risks and outcomes of choroidal nevus. RECENT FINDINGS: Choroidal nevus is a benign melanocytic tumor, often discovered incidentally on ophthalmic examination. This lesion is generally well circumscribed and pigmented. The prevalence of choroidal nevus in postequatorial region in United States adults (≥40 years old) is approximately 5%. Choroidal nevus is associated with higher lifetime unopposed estrogen and greater BMI...
January 30, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28138237/preparation-cytotoxicity-and-in-vivo-antitumor-efficacy-of-111-in-labeled-modular-nanotransporters
#8
Tatiana A Slastnikova, Andrey A Rosenkranz, Natalia B Morozova, Maria S Vorontsova, Vasiliy M Petriev, Tatiana N Lupanova, Alexey V Ulasov, Michael R Zalutsky, Raisa I Yakubovskaya, Alexander S Sobolev
PURPOSE: Modular nanotransporters (MNTs) are a polyfunctional platform designed to achieve receptor-specific delivery of short-range therapeutics into the cell nucleus by receptor-mediated endocytosis, endosome escape, and targeted nuclear transport. This study evaluated the potential utility of the MNT platform in tandem with Auger electron emitting (111)In for cancer therapy. METHODS: Three MNTs developed to target either melanocortin receptor-1 (MC1R), folate receptor (FR), or epidermal growth factor receptor (EGFR) that are overexpressed on cancer cells were modified with p-SCN-Bn-NOTA and then labeled with (111)In in high specific activity...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28126270/evisceration-and-ocular-tumors-what-are-the-consequences
#9
S Lemaître, A Lecler, C Lévy-Gabriel, C Reyes, L Desjardins, D Gentien, M Zmuda, P V Jacomet, L Lumbroso-Le Rouic, R Dendale, A Vincent-Salomon, G Pierron, O Galatoire, N Cassoux
PURPOSE: Evisceration can be performed for blind, painful eyes. This surgery can promote the dissemination of tumor cells within the orbit if an ocular tumor has been missed preoperatively. METHODS: We reviewed the medical records of patients who were eviscerated for blind, painful eyes between 2009 and 2014 and who were referred after the surgery to the Institut Curie or the Rothschild Foundation in Paris. We included the patients with a histological diagnosis of ocular tumor or orbital recurrence...
January 23, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28125759/clinical-features-differentiating-benign-from-malignant-conjunctival-tumors-in-children
#10
Carol L Shields, Kareem Sioufi, Adel E Alset, Nina S Boal, Mairghread G Casey, Austen N Knapp, Jordan A Sugarman, Marisa A Schoen, Phillip S Gordon, Emil Anthony T Say, Jerry A Shields
Importance: Conjunctival tumors in children are usually benign and rarely malignant. Objective: To evaluate clinical features of conjunctival tumors in children by comparing benign tumors with their malignant counterparts. Design, Setting, and Participants: This retrospective case series reviewed 806 cases of conjunctival tumor in children (aged <21 years) who were evaluated at a tertiary referral center between November 1, 1975, and July 1, 2015...
January 26, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28115829/ocular-melanoma-when-you-have-seen-one-you-have-not-seen-them-all-a-clinical-outcome-study-from-the-surveillance-epidemiology-and-end-results-seer-database-1973-2012
#11
Krishnaraj Mahendraraj, Sneha Shrestha, Christine Sm Lau, Ronald S Chamberlain
BACKGROUND: Ocular melanoma (OM) comprises <5% of all melanomas. Uveal melanoma (UM) is the most common subtype of OM, while conjunctival melanoma (CM) is rare and differs significantly from UM. The purpose of this study is to evaluate a large cohort of OM patients to differentiate demographic, pathologic, and clinical factors between these two neoplasms, which may affect treatment and outcomes. METHODS: The Surveillance, Epidemiology, and End Results database (1973-2012) was used to extract demographic and clinical data on 8,165 OM patients (92...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28105189/chrysin-induces-cell-apoptosis-in-human-uveal-melanoma-cells-via-intrinsic-apoptosis
#12
Chunyan Xue, Yueqin Chen, Dan-Ning Hu, Codrin Iacob, Chengwei Lu, Zhenping Huang
Uveal melanoma is the most common intraocular malignant tumor in adults. Chrysin is a flavonoid present in honey, propolis, various plants and herbs. In the present study, the cytotoxic effects of chrysin were investigated on human uveal melanoma cell lines (M17 and SP6.5) and associated signaling pathways, and a comparison to the effects on normal ocular cells [scleral fibroblasts and retinal pigment epithelial (RPE) cells] was performed. The effects of chrysin on cell viability were assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28074614/mutation-analysis-and-gene-expression-profiling-of-ocular-melanomas-in-cats
#13
J G Rushton, R Ertl, D Klein, B Nell
Feline ocular melanomas show a high malignant behaviour, but adjunctive therapies are non-existent. The aim of this pilot study was to determine, whether feline ocular melanomas harbour mutations comparable to mutations in human melanomas and to evaluate the gene expression status of genes known to be involved in initiation and progression of human melanomas. Mutation hotspot regions of several genes of feline ocular melanomas were analysed by DNA sequencing and RNA expression levels of the respective genes and others were evaluated by quantitative real-time polymerase chain reaction (RT-qPCR)...
January 11, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28069617/ocular-oncology-advances-in-retinoblastoma-uveal-melanoma-and-conjunctival-melanoma
#14
REVIEW
Marina Vasalaki, Ido D Fabian, M Ashwin Reddy, Victoria M L Cohen, Mandeep S Sagoo
BACKGROUND: Retinoblastoma, uveal and conjunctival melanomas are important malignancies within the remit of ocular oncology. Outlined are the diagnostic features and management principles, as well as advancements in the field and current challenges. SOURCES OF DATA: Original papers, reviews and guidelines. AREAS OF AGREEMENT: Most eyes with retinoblastoma (International Intraocular Retinoblastoma Classification (IIRC) Group A-D) are salvaged, whereas advanced cases (Group E) remain a challenge...
January 8, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/28047428/su-f-t-48-clinical-implementation-of-brachytherapy-planning-system-for-coms-eye-plaques
#15
C Ferreira, M Islam, S Ahmad, T De La Fuente Herman
PURPOSE: To commission the Brachytherapy Planning (BP) system (Varian, Palo Alto, CA) for the Collaborative Ocular Melanoma Study (COMS) eye plaques by evaluating dose differences against original plans from Nucletron Planning System (NPS). METHODS: NPS system is the primary planning software for COMS-plaques at our facility; however, Brachytherapy Planning 11.0.47 (Varian Medical Systems) is used for secondary check and for seed placement configurations not originally commissioned...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046271/su-f-t-659-nanoparticle-aided-eye-plaque-radiotherapy
#16
J Chin, W Ngwa
PURPOSE: Eye plaque brachytherapy is one of the approaches for radiotherapy treatment for ocular cancers: retinoblastoma and choroidal melanoma. This study, investigates the potential benefits of using gold nanoparticles to enhance therapeutic efficacy during eye plaque brachytherapy. METHODS: The EYE PHYSICS Inc. Plaque Simulator program distributed by IsoAid, LLC, Port Richey, Florida was used. It is based on the superposition of dose contributions from individual seeds following the TG-43 formalism...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28018148/epigenetics-and-common-ophthalmic-diseases
#17
REVIEW
Wendy Li, Ji Liu, Jennifer A Galvin
The study of ocular diseases and epigenetic dysregulation is an emerging area of research. The knowledge from the epigenetic mechanisms of DNA methylation, histone modifications, chromatin remodeling, and non-coding RNAs regarding the pathogenesis of ocular diseases will be helpful for improved treatment modalities for our patients. In particular, we focus upon the how epigenetic regulatory mechanisms impact five common ocular diseases: age related macular degeneration, age-related cataract, pterygium, retinoblastoma, and uveal melanoma...
December 2016: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/27932166/renal-allograft-failure-after-ipilimumab-therapy-for-metastatic-melanoma-a-case-report-and-review-of-the-literature
#18
A Jose, P Yiannoullou, S Bhutani, H Denley, M Morton, M Picton, A Summers, D van Dellen, T Augustine
Transplant recipients are at an increased risk of malignant melanoma, a result of chronic immunosuppression. Ipilimumab is a newer biological agent targeting T lymphocytes to potentiate an immune response against melanoma, and the use of this agent results in a new adverse effect profile that the clinician must be aware of while a patient is on therapy. We report the case of a male renal transplant recipient who developed graft failure while treated with ipilimumab and minimal immunosuppressive therapy for metastatic ocular melanoma, with biopsy evidence of glomerulonephritis and acute rejection...
November 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27919760/proton-therapy-present-and-future
#19
REVIEW
Radhe Mohan, David Grosshans
In principle, proton therapy offers a substantial clinical advantage over conventional photon therapy. This is because of the unique depth-dose characteristics of protons, which can be exploited to achieve significant reductions in normal tissue doses proximal and distal to the target volume. These may, in turn, allow escalation of tumor doses and greater sparing of normal tissues, thus potentially improving local control and survival while at the same time reducing toxicity and improving quality of life. Protons, accelerated to therapeutic energies ranging from 70 to 250MeV, typically with a cyclotron or a synchrotron, are transported to the treatment room where they enter the treatment head mounted on a rotating gantry...
January 15, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/27916271/correlation-of-gene-mutation-status-with-copy-number-profile-in-uveal-melanoma
#20
Serdar Yavuzyigitoglu, Wojtek Drabarek, Kyra N Smit, Natasha van Poppelen, Anna E Koopmans, Jolanda Vaarwater, Tom Brands, Bert Eussen, Hendrikus J Dubbink, Job van Riet, Harmen J G van de Werken, Berna Beverloo, Robert M Verdijk, Nicole Naus, Dion Paridaens, Emine Kilic, Annelies de Klein
No abstract text is available yet for this article.
December 1, 2016: Ophthalmology
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