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https://www.readbyqxmd.com/read/29664104/self-assembled-nanodiamond-supraparticles-for-anticancer-chemotherapy
#1
Yue Yu, Masahiro Nishikawa, Ming Liu, Takahiro Tei, Sunil C Kaul, Renu Wadhawa, Minfang Zhang, Junko Takahashi, Eijiro Miyako
A nanodiamond (ND) is a promising material for drug delivery applications owing to its relatively low cost, amenability to large-scale synthesis, unique structure, and low toxicity. However, synthesizing drug-loaded ND conjugates with uniform and tunable sizes, high loading capacity, efficacy in drug delivery, and versatility in terms of surface functionalization has been challenging. Here, we show that perfluorooctanoic acid-functionalized NDs spontaneously transform into well-dispersed and biocompatible supraparticle (SP) nanoclusters...
April 17, 2018: Nanoscale
https://www.readbyqxmd.com/read/29658266/enzyme-based-electrochemical-biosensor-for-therapeutic-drug-monitoring-of-anticancer-drug-irinotecan
#2
Maria Domenica Alvau, Stefano Tartaggia, Anna Meneghello, Bruno Casetta, Giammario Calia, Pier Andrea Serra, Federico Polo, Giuseppe Toffoli
Therapeutic drug monitoring (TDM) is the clinical practice of measuring pharmaceutical drug concentrations in patients' biofluids at designated intervals, thus allowing a close and timely control of their dosage. To date, TDM in oncology can only be performed by trained personnel in centralized laboratories and core facilities employing conventional analytical techniques (e.g. MS). CPT-11 is an antineoplastic drug that inhibits topoisomerase type I, causing cell death, and is widely used in the treatment of colorectal cancer...
April 16, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29611528/medication-overuse-in-oncology-current-trends-and-future-implications-for-patients-and-society
#3
REVIEW
Stephen M Schleicher, Peter B Bach, Konstantina Matsoukas, Deborah Korenstein
The high cost of cancer care worldwide is largely attributable to rising drugs prices. Despite their high costs and potential toxic effects, anticancer treatments could be subject to overuse, which is defined as the provision of medical services that are more likely to harm than to benefit a patient. We found 30 studies documenting medication overuse in cancer, which included 16 examples of supportive medication overuse and 17 examples of antineoplastic medication overuse in oncology. Few specific agents have been assessed, and no studies investigated overuse of the most toxic or expensive medications currently used in cancer treatment...
April 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29608397/optimizing-anticancer-therapy-in-metastatic-non-castrate-prostate-cancer-american-society-of-clinical-oncology-clinical-practice-guideline
#4
Michael J Morris, R Bryan Rumble, Ethan Basch, Sebastien J Hotte, Andrew Loblaw, Dana Rathkopf, Paul Celano, Rick Bangs, Matthew I Milowsky
Purpose This clinical practice guideline addresses abiraterone or docetaxel with androgen-deprivation therapy (ADT) for metastatic prostate cancer that has not been treated (or has been minimally treated) with testosterone-lowering agents. Methods Standard therapy for newly diagnosed metastatic prostate cancer has been ADT alone. Three studies have compared ADT alone with ADT and docetaxel, and two studies have compared ADT alone with ADT and abiraterone. Results Three prospective randomized studies (GETUG-AFU 15, STAMPEDE, and CHAARTED) examined overall survival (OS) with adding docetaxel to ADT...
April 2, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29601250/examining-trends-in-cost-and-clinical-benefit-of-novel-anticancer-drugs-over-time
#5
Ronak Saluja, Vanessa S Arciero, Sierra Cheng, Erica McDonald, William W L Wong, Matthew C Cheung, Kelvin K W Chan
PURPOSE: The purpose of this study was to determine if clinical benefits of novel anticancer drugs, measured by the ASCO Value Framework and European Society of Medical Oncology (ESMO) Magnitude of Clinical Benefit Scale, have increased over time in parallel with increasing costs. METHODS: Anticancer drugs from phase III randomized controlled trials cited for clinical efficacy evidence in drug approvals between January 2006 to December 2015 were identified and scored using both frameworks...
March 30, 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29578855/a-comparison-of-pharmacy-dispensing-channel-use-and-adherence-to-specialty-drugs-among-medicare-part-d-beneficiaries
#6
Hrishikesh P Kale, Anisha M Patel, Norman V Carroll
BACKGROUND: Nonadherence to specialty drugs has been associated with poor clinical and economic outcomes. Studies conducted using commercial health plans suggest that patients who use specialty pharmacies have higher adherence compared with patients using retail pharmacies. However, little is known about the frequency of dispensing channel use or the association of dispensing channel use with adherence to specialty drugs among Medicare Part D beneficiaries. OBJECTIVES: To (a) describe the use of pharmacy dispensing channels by patients using self-administered specialty drugs in Medicare Part D and (b) study the association between dispensing channel use and adherence to specialty drugs in this population...
April 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29549943/green-synthesis-of-water-soluble-nontoxic-inorganic-polymer-nanocomposites-containing-silver-nanoparticles-using-white-tea-extract-and-assessment-of-their-in-vitro-antioxidant-and-cytotoxicity-activities
#7
Zeinab Haghparasti, Mahnaz Mahdavi Shahri
The use of nontoxic biological compounds in the synthesis of nanomaterials is an ecofriendly and cost-effective approach in nanotechnology. The present work was carried out to develop silver nanoparticles (Ag-NPs) by a green method using white tea (Wt) extract as reducing agent for reduction of silver nitrate as silver precursor into the lamellar space of inorganic polymer montmorillonite (Mt) as an effective protective reagent and support as well. The bioformed Wt/Ag@Mt nanocomposite (NCs) was compared with pure biosynthesized Wt/Ag-NPs under free stabilizer condition and effect of Mt stabilizer on antioxidant, cytotoxicity and structural properties were also investigated...
June 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29534013/a-novel-hybrid-sequence-based-model-for-identifying-anticancer-peptides
#8
Lei Xu, Guangmin Liang, Longjie Wang, Changrui Liao
Cancer is a serious health issue worldwide. Traditional treatment methods focus on killing cancer cells by using anticancer drugs or radiation therapy, but the cost of these methods is quite high, and in addition there are side effects. With the discovery of anticancer peptides, great progress has been made in cancer treatment. For the purpose of prompting the application of anticancer peptides in cancer treatment, it is necessary to use computational methods to identify anticancer peptides (ACPs). In this paper, we propose a sequence-based model for identifying ACPs (SAP)...
March 13, 2018: Genes
https://www.readbyqxmd.com/read/29524443/readily-prepared-biodegradable-nanoparticles-to-formulate-poorly-water-soluble-drugs-improving-their-pharmacological-properties-the-example-of-trabectedin
#9
Umberto Capasso Palmiero, Lavinia Morosi, Ezia Bello, Marianna Ponzo, Roberta Frapolli, Cristina Matteo, Mariella Ferrari, Massimo Zucchetti, Lucia Minoli, Marcella De Maglie, Pierpaolo Romanelli, Massimo Morbidelli, Maurizio D'Incalci, Davide Moscatelli
The improvement of the pharmacological profile of lipophilic drug formulations is one of the main successes achieved using nanoparticles (NPs) in medicine. However, the complex synthesis procedure and numerous post-processing steps hamper the cost-effective use of these formulations. In this work, an approach which requires only a syringe to produce self-assembling biodegradable and biocompatible poly(caprolactone)-based NPs is developed. The effective synthesis of monodisperse NPs has been made possible by the optimization of the block copolymer synthesized via a combination of ring opening polymerization and reversible addition-fragmentation chain transfer polymerization...
March 7, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29514787/frequency-and-level-of-evidence-used-in-recommendations-by-the-national-comprehensive-cancer-network-guidelines-beyond-approvals-of-the-us-food-and-drug-administration-retrospective-observational-study
#10
COMPARATIVE STUDY
Jeffrey Wagner, John Marquart, Julia Ruby, Austin Lammers, Sham Mailankody, Victoria Kaestner, Vinay Prasad
OBJECTIVE: To determine the differences between recommendations by the National Comprehensive Cancer Network (NCNN) guidelines and Food and Drug Administration approvals of anticancer drugs, and the evidence cited by the NCCN to justify recommendations where differences exist. DESIGN: Retrospective observational study. SETTING: National Comprehensive Cancer Network and FDA. PARTICIPANTS: 47 new molecular entities approved by the FDA between 2011 and 2015...
March 7, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29463302/the-impact-of-pd-l1-on-survival-and-value-of-the-immune-check-point-inhibitors-in-non-small-cell-lung-cancer-proposal-policies-and-perspective
#11
Helmy M Guirgis
BACKGROUND: The impact of programmed death receptor-ligand1 (PD-L1) on costs and value of the immune check point inhibitors (ICPI) has received minimal attention. OBJECTIVES: 1- Design a sliding scale to grade survival in 2nd-line non-small-cell lung cancer (NSCLC). 2- Compare costs and value of Nivolumab (Nivo), Atezolizumab (Atezo) and Pembrolizumab (Pembro) vs. Docetaxel (Doc). METHODS: Previously reported median overall survival (OS) and prices posted by parent company were utilized...
February 20, 2018: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29444609/optimization-of-resources-by-drug-management-a-multicentred-web-administered-study-on-the-use-of-ipilimumab-in-italy
#12
V Damuzzo, A Russi, M Chiumente, C Masini, B Rebesco, F Gregis, S Nozza, J Pigozzo, V Chiarion-Sileni, A C Palozzo
Objective In a scenario of new expensive cancer therapies entering the market, strategies of optimisation and cost containment are crucial in oncology care. Better management of drug waste and centralization of drug preparation can be effective strategies to achieve these goals. The aim of this work is to describe the economic management of a high cost anticancer drug (ipilimumab) in some Italian reference centres. Methods This was an observational, multicentred study in which economical and clinical data of 21 cancer centres (418 patients) were collected during the enrollment period from February 2013 to August 2014...
January 1, 2018: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29443649/use-of-charity-financial-assistance-for-novel-oral-anticancer-agents
#13
Adam J Olszewski, Andrew R Zullo, Christopher R Nering, Justin P Huynh
Novel oral targeted drugs are increasingly used for cancer therapy, but their extreme cost, often exceeding $10,000 per month, poses a significant barrier for patients and insurers alike, leading to the potential breakdown of traditional cost-sharing strategies. Insured patients' routine use of charity assistance to supplement their coverage would indicate a major deficiency in the current health care policies. By using data from a specialty pharmacy affiliated with an academic center (1,557 prescriptions dispensed between January 2014 and March 2017), we examined sources of payment for novel oral anticancer agents, distinguishing contributions from health insurance, patients, and from charitable assistance organizations...
February 13, 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29423618/organotypic-models-of-lung-cancer
#14
Anna Pomerenke
Human lung cancer is one of the leading causes of death worldwide, with nearly 2 million of new cases diagnosed each year, often too late for a successful therapeutic intervention. In this chapter, organotypic models of lung cancer will be reviewed. Ex vivo tissue explants, spheroids, organoids, and novel bioengineering approaches are currently being used to study human lung cancer. Although there is no ideal method that will fully recapitulate the complex human lung architecture, the three-dimensional (3D) organotypic models described here represent a major advance from classical two-dimensional (2D) tissue culture models...
February 9, 2018: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/29412947/novel-tungsten-phosphide-embedded-nitrogen-doped-carbon-nanotubes-a-portable-and-renewable-monitoring-platform-for-anticancer-drug-in-whole-blood
#15
Haifeng Zhou, Guoxia Ran, Jean-Francois Masson, Chan Wang, Yuan Zhao, Qijun Song
Biosensors based on converting the concentration of analytes in complex samples into single electrochemical signals are attractive candidates as low cost, high-throughput, portable and renewable sensor platforms. Here, we describe a simple but practical analytical device for sensing an anticancer drug in whole blood, using the detection of methotrexate (MTX) as a model system. In this biosensor, a novel carbon-based composite, tungsten phosphide embedded nitrogen-doped carbon nanotubes (WP/N-CNT), was fixed to the electrode surface that supported redox cycling...
May 15, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29408473/curcumin-marinosomes-as-promising-nano-drug-delivery-system-for-lung-cancer
#16
Shaimaa Ibrahim, Tatsuaki Tagami, Toshihiro Kishi, Tetsuya Ozeki
Lung cancer is the major cause of cancer-related death worldwide. Curcumin attracted attention due to its promising anti-cancer properties, however its poor aqueous solubility and bioavailability have to be overcome. In the current study curcumin is encapsulated in krill lipids-based liposomes (marinosomes) to develop a potential anticancer therapy from low-cost and readily available nutraceuticals. Reflux followed by thin drug-lipid film method is used successfully to incorporate the drug into the liposomal membrane at high encapsulation efficiency (EE)...
April 5, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29407145/simple-fabrication-of-rough-halloysite-nanotubes-coatings-by-thermal-spraying-for-high-performance-tumor-cells-capture
#17
Rui He, Mingxian Liu, Yan Shen, Rong Liang, Wei Liu, Changren Zhou
Here, we reported a fast, low-cost, and effective fabrication method of large-area and rough halloysite nanotubes (HNTs) coatings by thermal spraying of HNTs ethanol dispersions. A uniform HNTs coating with high transparence is achieved with tailorable surface roughness and thickness. Compared with normal cells, the tumor cells can be captured effectively with high capture yield by the HNTs coatings (expect HeLa cells), which is attributed to the enhanced topographic interactions between HNTs coating and cancer cells...
April 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29401391/systematic-computational-design-and-identification-of-low-picomolar-inhibitors-of-aurora-kinase-a
#18
Hwangseo Park, Hoi-Yun Jung, Shinmee Mah, Sungwoo Hong
Aurora kinase A (AKA) has served as an effective molecular target for the development of cancer therapeutics. A series of potent AKA inhibitors with the (4-methoxy-pyrimidin-2-yl)-phenyl-amine (MPPA) scaffold are identified using a systematic computer-aided drug design protocol involving structure-based virtual screening, de novo design, and free energy perturbation (FEP) simulations. To enhance the accuracy of the virtual screening to find a proper molecular core and de novo design to optimize biochemical potency, we preliminarily improved the scoring function by implementing a reliable hydration energy term...
February 5, 2018: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29400987/dose-rounding-of-biologic-and-cytotoxic-anticancer-agents-a-position-statement-of-the-hematology-oncology-pharmacy-association
#19
Rebecca Fahrenbruch, Polly Kintzel, Anne Marie Bott, Steven Gilmore, Ryan Markham
PURPOSE: To present a position statement from the Hematology/Oncology Pharmacy Association (HOPA) that pertains to dose rounding of biologic and cytotoxic anticancer agents. METHODS: The HOPA Standards Committee organized a work group of oncology pharmacist specialists to examine the safety and value of dose rounding of biologic and cytotoxic anticancer agents. Primary literature that describes methods for dose rounding, with clinical or economic data, were analyzed...
February 5, 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29395016/-economic-impact-of-centralization-of-chemotherapy-preparation-experience-of-the-national-institute-of-oncology-of-rabat
#20
I Bennani, M Alami Chentoufi, S Serragui, R Razine, B Meddah
INTRODUCTION: Centralized preparation of anticancer drugs meets quality and safety objectives. Its economic interest has been the subject of several studies, with very heterogeneous methodological approaches. OBJECTIVE: This study evaluates the economic impact of the centralization of the preparation of chemotherapy in the national institute of oncology of Rabat, the referral institute in the management of cancer in Morocco. MATERIALS AND METHODS: The analysis included 3000 preparations...
January 27, 2018: Annales Pharmaceutiques Fran├žaises
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