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Inflammation research

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https://www.readbyqxmd.com/read/29351433/%C3%AE-nitrostyrene-derivatives-attenuate-lps-mediated-acute-lung-injury-via-the-inhibition-of-neutrophil-platelet-interactions-and-net-release
#1
Yao-Wen Chang, Ching-Ping Tseng, Chih-Hsun Lee, Tsong-Long Hwang, Yu-Li Chen, Mei-Tzu Su, Kowit-Yu Chong, Ying-Wei Lan, Chin-Chung Wu, Kung-Ju Chen, Fen-Hua Lu, Hsiang-Ruei Liao, Chuen Hsueh, Pei-Wen Hsieh
Acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) are high-mortality and life-threatening diseases that are associated with neutrophil activation and accumulation within lung tissue. Emerging evidence indicates that neutrophil-platelet aggregates (NPAs) at sites of injury increases acute inflammation and contributes to the development of ALI. Even though numerous studies have increased our understanding of the pathophysiology of ALI, there is still a lack of innovative and useful treatments that reduce mortality, emphasizing that there is an urgent need for novel treatment strategies...
January 11, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29351216/in-silico-and-in-vitro-study-of-the-bromelain-phytochemical-complex-inhibition-of-phospholipase-a2-pla2
#2
Fatahiya Mohamed Tap, Fadzilah Adibah Abd Majid, Hassan Fahmi Ismail, Tet Soon Wong, Kamyar Shameli, Mikio Miyake, Nurul Bahiyah Ahmad Khairudin
Phospholipase A2 (Pla2) is an enzyme that induces inflammation, making Pla2 activity an effective approach to reduce inflammation. Therefore, investigating natural compounds for this Pla2 inhibitory activity has important therapeutic potential. The objective of this study was to investigate the potential in bromelain-phytochemical complex inhibitors via a combination of in silico and in vitro methods. Bromelain-amenthoflavone displays antagonistic effects on Pla2. Bromelian-asiaticoside and bromelain-diosgenin displayed synergistic effects at high concentrations of the combined compounds, with inhibition percentages of more than 70% and 90%, respectively, and antagonistic effects at low concentrations...
January 19, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29351052/particulate-coral-hydroxyapatite-sheltered-by-titanium-mesh-for-localized-alveolar-rehabilitation-after-onlay-graft-failure-a-case-report
#3
Miao Zhou, Shuyi Li, Hendrik Terheyden, Shuaishuai Cao, Yuejuan Che, Yuanming Geng
Reconstruction of bone loss in the alveolar ridge has long been challenging. Autologous bone grafts are considered as the "golden standard", while little research has focused on how to repair pronounced alveolar bone defects after autologous bone graft failure. The aim of this study was to detail a method based on the titanium mesh technique coupled with particulate coral hydroxyapatite to solve the Onlay graft failure. With bone deficiency in the #11 and #24- #25 regions, we harvested two autologous bone blocks for reconstruction...
January 19, 2018: Journal of Oral Implantology
https://www.readbyqxmd.com/read/29350435/from-micro-to-macro-structures-in-multiple-sclerosis-what-is-the-added-value-of-diffusion-imaging
#4
Mara Cercignani, Claudia Gandini Wheeler-Kingshott
Diffusion imaging has been instrumental in understanding damage to the central nervous system as a result of its sensitivity to microstructural changes. Clinical applications of diffusion imaging have grown exponentially over the past couple of decades in many neurological and neurodegenerative diseases, such as multiple sclerosis (MS). For several reasons, MS has been extensively researched using advanced neuroimaging techniques, which makes it an 'example disease' to illustrate the potential of diffusion imaging for clinical applications...
January 19, 2018: NMR in Biomedicine
https://www.readbyqxmd.com/read/29350049/targeted-and-off-target-bystander-and-abscopal-effects-of-radiation-therapy-redox-mechanisms-and-risk-benefit-analysis
#5
Jean-Pierre Pouget, Alexandros G Georgakilas, Jean-Luc Ravanat
Radiation therapy (from external beams to unsealed and sealed radionuclide sources) takes advantage of the detrimental effects of the clustered production of radicals and reactive oxygen species (ROS). Research has mainly focused on the interaction of radiation with water, which is the major constituent of living beings, and with nuclear DNA, which contains the genetic information. This led to the so-called "target" theory according to which cells have to be hit by ionizing particles to elicit an important biological response, including cell death...
January 19, 2018: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29350018/allergy-and-high-trait-anxiety-are-related-to-increases-in-heart-rate-variability-results-of-naturalistic-long-term-design-study
#6
J Rajcani, P Solarikova, I Brezina
A number of studies report heart rate variability (HRV) changes in allergic as well as high trait anxious people, and associations between allergic inflammation and trait anxiety. This study investigated HRV of 20 low anxious allergic, 19 healthy high trait anxious and 18 healthy low anxious, in naturalistic setting. On arranged research days, subjects performed measurements using portable ECG device and subjective self-assessment of perceived stress. Five repeated measurements data from each subject have shown increases in overall HRV, as well as HRV on respiratory frequencies in both allergy and high trait anxiety...
January 2018: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29349273/the-contribution-of-three-dimensions-of-allostatic-load-to-racial-ethnic-disparities-in-poor-fair-self-rated-health
#7
Alexis R Santos-Lozada, Jonathan Daw
Objective: This study evaluates whether different dimensions of physiological dysregulation, modeled individually rather than additively mediate racial/ethnic disparities in self-reported health. Methods: Using data from the National Health and Nutrition Examination Survey (2005-2010) and the Karlson, Hold, and Breen (KHB) mediation model, this paper explores what operationalization of biomarker data most strongly mediate racial/ethnic disparities in poor/fair self-rated health (SRH) among adults in the United States, net of demographic, socioeconomic, behavioral, and medication controls...
April 2018: SSM—Population Health
https://www.readbyqxmd.com/read/29348584/quail-egg-homogenate-alleviates-food-allergy-induced-eosinophilic-esophagitis-like-disease-through-modulating-par-2-transduction-pathway-in-peanut-sensitized-mice
#8
Priscilia Lianto, Shiwen Han, Xinrui Li, Fredrick Onyango Ogutu, Yani Zhang, Zhuoyan Fan, Huilian Che
The present pharmacotherapy for eosinophilic esophagitis (EoE) fundamentally depend on inhaled corticosteroids. Despite the fact that oral intake of topical steroids can be successful in restricting EoE-related inflammation, there are concerns with respect to the long term utilization of steroids, especially in kids. In the current research, we assess the effect of quail egg, which is reportedly a known serine protease inhibitor, on symptomatology and immune responses in a peanut-sensitized mouse model of food allergy induced EoE...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348369/-history-of-researches-on-myalgic-encephalomyelitis-chronic-fatigue-syndrome
#9
Yasuyoshi Watanabe, Hirohiko Kuratsune
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disease characterized by chronic, profound, disabling, and unexplained fatigue. The first patient with ME/CFS in Japan was identified and described in 1990 by Prof. Teruo Kitani and Dr. Hirohiko Kuratsune of the Research Institute for Microbial Diseases, Osaka University. Since then, a variety of studies have been performed to determine the objective biomarkers of the disease. Although it is hypothesized that brain inflammation is involved in the pathophysiology of ME/CFS, there is to date no direct evidence of neuroinflammation in patients with ME/CFS...
January 2018: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/29345167/dietary-supplements-for-health-adaptation-and-recovery-in-athletes
#10
Eric S Rawson, Mary P Miles, D Enette Larson-Meyer
Some dietary supplements are recommended to athletes based on data that supports improved exercise performance. Other dietary supplements are not ergogenic per se, but may improve health, adaptation to exercise, or recovery from injury, and so could help athletes to train and/or compete more effectively. In this review, we describe several dietary supplements that may improve health, exercise adaptation, or recovery. Creatine monohydrate may improve: recovery from and adaptation to intense training, recovery from periods of injury with extreme inactivity, cognitive processing, and reduce severity of or enhance recovery from mild traumatic brain injury (mTBI)...
January 18, 2018: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/29344413/therapeutic-potential-and-cellular-mechanisms-of-panax-notoginseng-on-prevention-of-aging-and-cell-senescence-associated-diseases
#11
REVIEW
Haiping Zhao, Ziping Han, Guangwen Li, Sijia Zhang, Yumin Luo
Owing to a dramatic increase in average life expectancy, most countries in the world are rapidly entering an aging society. Therefore, extending health span with pharmacological agents targeting aging-related pathological changes, are now in the spotlight of gerosciences. Panax notoginseng (Burk.) F. H. Chen, a species of the genus Panax, has been called the "Miracle Root for the Preservation of Life," and has long been used as a Chinese herb with magical medicinal value. Panax notoginseng has been extensively employed in China to treat microcirculatory disturbances, inflammation, trauma, internal and external bleeding due to injury, and as a tonic...
December 2017: Aging and Disease
https://www.readbyqxmd.com/read/29344353/effects-of-tnf-receptor-blockade-on-in-vitro-cell-survival-and-response-to-negative-energy-balance-in-dairy-cattle
#12
C A Martel, L K Mamedova, J E Minton, M Garcia, C Legallet, B J Bradford
Background: Associative data and some controlled studies suggest that the inflammatory cytokine tumor necrosis factor (TNF) α can induce fatty liver in dairy cattle. However, research demonstrating that TNFα is a necessary component in the etiology of bovine fatty liver is lacking. The aim of this work was to evaluate whether blocking TNFα signaling with a synthetic cyclic peptide (TNF receptor loop peptide; TRLP) would improve liver metabolic function and reduce triglyceride accumulation during feed restriction...
2018: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/29343528/effect-of-intravitreal-triamcinolone-acetonide-injection-at-the-end-of-vitrectomy-for-vitreous-haemorrhage-related-to-proliferative-diabetic-retinopathy
#13
Yoshihiro Takamura, Masahiko Shimura, Takashi Katome, Hideaki Someya, Masahiko Sugimoto, Takao Hirano, Taiji Sakamoto, Makoto Gozawa, Takehiro Matsumura, Masaru Inatani
BACKGROUND/AIMS: To investigate whether intravitreal injection of triamcinolone acetonide (IVTA) combined with vitrectomy prevents postoperative inflammation in patients with vitreous haemorrhage (VH) due to proliferative diabetic retinopathy (PDR). METHODS: This prospective, multicentre, randomised study conducted at seven sites in Japan enrolled patients diagnosed as having VH following PDR. Patients underwent vitrectomy with (IVTA+VIT group) or without (VIT group) IVTA at the end of the surgery...
January 17, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29343510/limited-radiographic-progression-and-sustained-reductions-in-mri-inflammation-in-patients-with-axial-spondyloarthritis-4-year-imaging-outcomes-from-the-rapid-axspa-phase-iii-randomised-trial
#14
Désirée van der Heijde, Xenofon Baraliakos, Kay-Geert A Hermann, Robert B M Landewé, Pedro M Machado, Walter P Maksymowych, Owen R Davies, Natasha de Peyrecave, Bengt Hoepken, Lars Bauer, Tommi Nurminen, Juergen Braun
OBJECTIVES: To report 4-year imaging outcomes in the RAPID-axSpA (NCT01087762) study of patients with ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nr-axSpA), treated with certolizumab pegol (CZP). METHODS: This phase III, randomised trial was placebo-controlled and double-blind to week 24, dose-blind to week 48 and open-label to week 204. Patients fulfilling the Assessment of Spondyloarthritis International Society (ASAS) axSpA criteria with active disease were stratified (AS/nr-axSpA) according to the modified New York (mNY) criteria at randomisation...
January 17, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29343315/subclinical-inflammation-affects-iron-and-vitamin-a-but-not-zinc-status-assessment-in-senegalese-children-and-cambodian-children-and-women
#15
Marion Fiorentino, Marlène Perignon, Khov Kuong, Chhoun Chamnan, Jacques Berger, Frank T Wieringa
OBJECTIVE: To assess the impact of the acute-phase response (APR) during inflammation on Fe, Zn and vitamin A biomarkers to allow accurate evaluation of micronutrient status in populations. DESIGN: Ferritin (FER), soluble transferrin receptor (TfR), retinol-binding protein (RBP), Zn, α1-acid glycoprotein and C-reactive protein concentrations were measured. Correction factors (CF) for each biomarker were calculated as the ratio for groups at different stages of inflammation v...
January 18, 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/29342918/abnormal-sphingolipid-world-in-inflammation-specific-for-lysosomal-storage-diseases-and-skin-disorders
#16
REVIEW
Marta Moskot, Katarzyna Bocheńska, Joanna Jakóbkiewicz-Banecka, Bogdan Banecki, Magdalena Gabig-Cimińska
Research in recent years has shown that sphingolipids are essential signalling molecules for the proper biological and structural functioning of cells. Long-term studies on the metabolism of sphingolipids have provided evidence for their role in the pathogenesis of a number of diseases. As many inflammatory diseases, such as lysosomal storage disorders and some dermatologic diseases, including psoriasis, atopic dermatitis and ichthyoses, are associated with the altered composition and metabolism of sphingolipids, more studies precisely determining the responsibilities of these compounds for disease states are required to develop novel pharmacological treatment opportunities...
January 15, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29342113/mitochondria-oxidative-stress-and-the-kynurenine-system-with-a-focus-on-ageing-and-neuroprotection
#17
REVIEW
Katalin Sas, Elza Szabó, László Vécsei
In this review, the potential causes of ageing are discussed. We seek to gain insight into the main physiological functions of mitochondria and discuss alterations in their function and the genome, which are supposed to be the central mechanisms in senescence. We conclude by presenting the potential modulating role of the kynurenine pathway in the ageing processes. Mitochondrial dynamics are supposed to have important physiological roles in maintaining cell homeostasis. During ageing, a decrease in mitochondrial dynamics was reported, potentially compromising the function of mitochondria...
January 17, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29339735/phenotype-and-functional-features-of-human-telomerase-reverse-transcriptase-immortalized-human-airway-smooth-muscle-cells-from-asthmatic-and-non-asthmatic-donors
#18
J K Burgess, A Ketheson, A Faiz, K A Limbert Rempel, B G Oliver, J P T Ward, A J Halayko
Asthma is an obstructive respiratory disease characterised by chronic inflammation with airway hyperresponsiveness. In asthmatic airways, there is an increase in airway smooth muscle (ASM) cell bulk, which differs from non-asthmatic ASM in characteristics. This study aimed to assess the usefulness of hTERT immortalisation of human ASM cells as a research tool. Specifically we compared proliferative capacity, inflammatory mediator release and extracellular matrix (ECM) production in hTERT immortalised and parent primary ASM cells from asthmatic and non-asthmatic donors...
January 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29338843/current-status-of-animal-models-of-posttraumatic-stress-disorder-behavioral-and-biological-phenotypes-and-future-challenges-in-improving-translation
#19
REVIEW
Jessica Deslauriers, Mate Toth, Andre Der-Avakian, Victoria B Risbrough
Increasing predictability of animal models of posttraumatic stress disorder (PTSD) has required active collaboration between clinical and preclinical scientists. Modeling PTSD is challenging, as it is a heterogeneous disorder with ≥20 symptoms. Clinical research increasingly utilizes objective biological measures (e.g., imaging, peripheral biomarkers) or nonverbal behaviors and/or physiological responses to complement verbally reported symptoms. This shift toward more-objectively measurable phenotypes enables refinement of current animal models of PTSD, and it supports the incorporation of homologous measures across species...
November 20, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29338496/repeated-lipopolysaccharide-exposure-modifies-immune-and-sickness-behaviour-response-in-an-animal-model-of-chronic-inflammation
#20
Ksenia Musaelyan, Steven Aldridge, Andrea Du Preez, Martin Egeland, Patricia A Zunszain, Carmine M Pariante, Sandrine Thuret, Cathy Fernandes
Repeated lipopolysaccharide exposure is often used in longitudinal preclinical models of depression. However, the potential phenotypic differences from acute depression-mimicking effects are rarely described. This study compared chronic lipopolysaccharide administration of doses previously used in depression research to a new mode of escalating dose injections. Adult male BALB/c mice ( n=8/group) were injected intraperitoneally with either a single 0.83 mg/kg dose, a repeated 0.1 mg/kg lipopolysaccharide dose or a dose which escalated weekly from 0...
January 1, 2018: Journal of Psychopharmacology
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