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https://www.readbyqxmd.com/read/28817387/response-of-an-ovarian-granulosa-cell-tumor-with-everolimus-and-exemestane-after-initial-response-to-letrozole
#1
Tarek Assi, Hampig R Kourie, Elie El Rassy, Tania Moussa, Joseph Kattan
Granulosa cell tumors of the ovaries (GCTO), the most common sex cord tumors of the female genitalia, are characterized by a remarkably favorable prognosis but tend to recur even after several years of follow-up. Standard approach to manage these relapsing tumors is almost inexistent and physicians' choice is most commonly based on his/her personal expertise. Recently, the use of hormone therapy in GCTO has induced prolonged response and survival. In this case report, we report the first successful use of everolimus in the combination of exemestane to reverse the resistance to hormonal therapy with letrozole in a 53-year-old woman with GCTO...
September 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/28816598/short-versus-long-double-stranded-rna-activation-of-a-post-transcriptional-gene-knockdown-pathway
#2
Nir Shpak, Rivka Manor, Lihie Katzir Abilevich, Ortal Mantal, Keshet Shavit, Eliahu D Aflalo, Debra Toiber, Amir Sagi
RNA interference (RNAi) utilizes a conserved cellular autoimmune defense mechanism involving the internalization of dsRNA into cells and the activation of a set of RNAi related genes. Using RNAi, complete sex reversal is achievable in males of the prawn Macrobrachium rosenbergii by knocking down the transcript level of an insulin-like androgenic gland hormone (Mr-IAG) through injections of dsRNA of the entire Mr-IAG ORF sequence (dsMr-IAG - 518 bp). Interestingly, in-vivo knockdown success and dsMr-IAG lengths seemed to correlate, with long dsRNA being the most effective and short dsRNA fragments showing no effect...
August 17, 2017: RNA Biology
https://www.readbyqxmd.com/read/28812624/perceptive-costs-of-reproduction-drive-ageing-and-physiology-in-male-drosophila
#3
Zachary M Harvanek, Yang Lyu, Christi M Gendron, Jacob C Johnson, Shu Kondo, Daniel E L Promislow, Scott D Pletcher
Costs of reproduction are thought to result from natural selection optimizing organismal fitness within putative physiological constraints. Phenotypic and population genetic studies of reproductive costs are plentiful across taxa, but an understanding of their mechanistic basis would provide important insight into the diversity in life-history traits, including reproductive effort and ageing. Here, we dissect the causes and consequences of specific costs of reproduction in male Drosophila melanogaster. We find that key survival and physiological costs of reproduction arise from perception of the opposite sex, and they are reversed by the act of mating...
May 15, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28811233/stimulation-of-ovarian-cell-proliferation-by-tetrabromobisphenol-a-but-not-tetrachlorobisphenol-a-through-g-protein-coupled-receptor-30
#4
Marta Hoffmann, Justyna Gogola, Małgorzata Kotula-Balak, Anna Ptak
Tetrabromobisphenol A (TBBPA) and tetrachlorobisphenol A (TCBPA) are bisphenol A (BPA) analogs, where the phenolic moieties are substituted with halogens (Br or Cl). Previous studies indicate that BPA has significant proliferative effects on in vitro cultured epithelial ovarian cancer (EOC) cells. Considering this, we analyzed the effects of both TBBPA and TCBPA at 1, 10, and 50nM on ovarian cancer cell proliferation. The majority of malignant ovarian tumors are epithelial in origin, but approximately 10% are classified as ovarian sex cord tumors, with the most common type being granulosa cell tumors (GCTs)...
August 12, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28810541/microrna-130a-is-highly-expressed-in-the-esophageal-mucosa-of-achalasia-patients
#5
Hiroyuki Shoji, Hajime Isomoto, Akira Yoshida, Haruo Ikeda, Hitomi Minami, Tsutomu Kanda, Shigetoshi Urabe, Kayoko Matsushima, Fuminao Takeshima, Kazuhiko Nakao, Haruhiro Inoue
Esophageal achalasia is considered as a risk factor of esophageal cancer. The etiologies of esophageal achalasia remain unknown. Peroral endoscopic myotomy (POEM) has recently been established as a minimally invasive method with high curability. The aims of the present study were to identify the microRNAs (miRs) specific to esophageal achalasia, to determine their potential target genes and to assess their alteration following POEM. RNA was extracted from biopsy samples from middle esophageal mucosa and analyzed using a microarray...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28807754/transgenerational-effects-of-early-environmental-insults-on-aging-and-disease-incidence
#6
REVIEW
Mirela Ambeskovic, Tessa J Roseboom, Gerlinde A S Metz
Adverse early life experiences are major influences on developmental trajectories with potentially life-long consequences. Prenatal or early postnatal exposure to stress, undernutrition or environmental toxicants may reprogram brain development and increase risk of behavioural and neurological disorders later in life. Not only experience within a single lifetime, but also ancestral experience affects health trajectories and chances of successful aging. The central mechanism in transgenerational programming of a disease may the formation of epigenetic memory...
August 11, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28806479/zika-virus-disease-in-children-in-colombia-august-2015-to-may-2016
#7
Natalia Tolosa, Sarah C Tinker, Oscar Pacheco, Diana Valencia, Daniela Salas Botero, Van T Tong, Marcela Mercado, Suzanne M Gilboa, Maritza Gonzalez, Christina A Nelson, Lissethe Pardo, Carol Y Rao, Angélica Rico, Meredith Moore, Edgar Parra, Margaret A Honein, Martha L Ospina Martínez
BACKGROUND: Children are considered a potentially vulnerable population for Zika virus infection. However, data on paediatric Zika virus infection are sparse. METHODS: We analysed data from Colombia's national surveillance system during the 2015-2016 Zika virus outbreak on patients meeting the clinical case definition of Zika virus disease (ZVD) among children aged 1 month to 18 years to estimate incidence by demographic characteristics and characterize the occurrence of selected complications...
August 14, 2017: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/28801730/prospective-changes-in-neural-alcohol-cue-reactivity-in-at-risk-adolescents
#8
Tam T Nguyen-Louie, Kelly E Courtney, Lindsay M Squeglia, Kara Bagot, Sonja Eberson, Robyn Migliorini, Alexis R Alcaraz, Susan F Tapert, Carmen Pulido
Adolescence represents an ideal time for elucidating the etiology of cue reactivity profiles. This study examined the influence of three risk factors consistently associated with heavy adolescent drinking on alcohol cue reactivity. Youth were first assessed while still naïve to alcohol (12-14 years old) and followed after transitioning into alcohol use (17-21 years old). The effects of family history of substance use disorder, sex, and history of early of dating (i.e., before 14 years of age) on BOLD response contrast to alcohol picture cues were examined in a linear mixed model, controlling for age and alcohol use patterns at follow-up...
August 11, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28799325/comparison-between-next-generation-and-sanger-based-sequencing-for-the-detection-of-transmitted-drug-resistance-mutations-among-recently-infected-hiv-1-patients-in-israel-2000-2014
#9
Roy Moscona, Daniela Ram, Marina Wax, Efrat Bucris, Itzchak Levy, Ella Mendelson, Orna Mor
INTRODUCTION: Transmitted drug-resistance mutations (TDRM) may hamper successful anti-HIV-1 therapy and impact future control of the HIV-1 epidemic. Recently infected, therapy-naïve individuals are best suited for surveillance of such TDRM. In this study, TDRM, detected by next-generation sequencing (NGS) were compared to those identified by Sanger-based population sequencing (SBS) in recently infected HIV-1 patients. METHODS: Historical samples from 80 recently infected HIV-1 patients, diagnosed between 2000 and 2014, were analysed by MiSeq (NGS) and ABI (SBS)...
August 11, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28794851/expression-of-jazf1-abcc8-kcnj11and-notch2-genes-and-vitamin-d-receptor-polymorphisms-in-type-2-diabetes-and-their-association-with-microvascular-complications
#10
Maha A Rasheed, Nagwa Kantoush, Nagwa Abd El-Ghaffar, Hebatallah Farouk, Solaf Kamel, Alshaymaa Ahmed Ibrahim, Aliaa Shalaby, Eman Mahmoud, Hala M Raslan, Omneya M Saleh
BACKGROUND: We studied JAZF1, ABCC8, KCNJ11and Notch2 gene expression and vitamin D receptor (VDR) polymorphisms (Fok1 and Bsm1) in patients with type 2 diabetes mellitus (T2DM) and tried to find out their association with microvascular complications in these patients. METHODS: The study was conducted on 180 patients (93 complicated and 87 noncomplicated) and 150 healthy subjects. Reverse-transcriptase polymerase chain reaction (RT-PCR) was used to assess gene expression and real-time PCR was used to detect VDR genotypes...
June 2017: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28794219/dodging-silver-bullets-good-crispr-gene-drive-design-is-critical-for-eradicating-exotic-vertebrates
#11
Thomas A A Prowse, Phillip Cassey, Joshua V Ross, Chandran Pfitzner, Talia A Wittmann, Paul Thomas
Self-replicating gene drives that can spread deleterious alleles through animal populations have been promoted as a much needed but controversial 'silver bullet' for controlling invasive alien species. Homing-based drives comprise an endonuclease and a guide RNA (gRNA) that are replicated during meiosis via homologous recombination. However, their efficacy for controlling wild populations is threatened by inherent polymorphic resistance and the creation of resistance alleles via non-homologous end-joining (NHEJ)-mediated DNA repair...
August 16, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28794047/no-substantial-evidence-for-sexual-transmission-of-minority-hiv-drug-resistance-mutations-in-men-who-have-sex-with-men
#12
Antoine Chaillon, Masato Nakazawa, Joel O Wertheim, Susan J Little, Davey M Smith, Sanjay R Mehta, Sara Gianella
During primary HIV-infection, the presence of minority drug resistant mutations (DRM) may be a consequence of sexual transmission, de novo mutations or technical errors. Baseline blood samples were collected from 24 HIV-infected antiretroviral-naive, genetically- and epidemiologically- linked source and recipient partners, shortly after the recipient's estimated date of infection. An additional 32 longitudinal samples were available from 11 recipients. Deep-sequencing of HIV reverse transcriptase (RT) was performed (Roche/454) and screened for nucleoside and non-nucleoside RT inhibitor DRM...
August 9, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28792122/acceleration-of-fracture-healing-by-overexpression-of-basic-fibroblast-growth-factor-in-the-mesenchymal-stromal-cells
#13
Hongliang Zhang, Alexander Kot, Yu-An E Lay, Fernando A Fierro, Haiyan Chen, Nancy E Lane, Wei Yao
In this study, we engineered mesenchymal stem cells (MSCs) to over-express basic fibroblast growth factor (bFGF) and evaluated its effects on fracture healing. Adipose-derived mouse MSCs were transduced to express bFGF and green fluorescence protein (ADSC(bFGF) -GFP). Closed-femoral fractures were performed with osterix-mCherry reporter mice of both sexes. The mice received 3 × 10(5) ADSCs transfected with control vector or bFGF via intramuscular injection within or around the fracture sites. Mice were euthanized at days 7, 14, and 35 to monitor MSC engraftment, osteogenic differentiation, callus formation, and bone strength...
August 9, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28791553/sex-differences-in-discrimination-reversal-learning-in-the-guppy
#14
Maria Elena Miletto Petrazzini, Angelo Bisazza, Christian Agrillo, Tyrone Lucon-Xiccato
In several mammalian and avian species, females show a higher performance than males in tasks requiring cognitive flexibility such as the discrimination reversal learning. A recent study showed that female guppies are twice as efficient as males in a reversal learning task involving yellow-red discrimination, suggesting a higher cognitive flexibility in female guppies. However, the possibility exists that the superior performance exhibited by females does not reflect a general sex difference in cognitive abilities, but instead, is confined to colour discrimination tasks...
August 8, 2017: Animal Cognition
https://www.readbyqxmd.com/read/28791445/pre-operative-factors-influence-the-recovery-of-range-of-motion-following-reverse-shoulder-arthroplasty
#15
Philippe Collin, Tetsuya Matsukawa, Patrick J Denard, Solenn Gain, Alexandre Lädermann
INTRODUCTION: Recently the use of reverse shoulder arthroplasty (RSA) has increased because of a clinical perception of durable functional outcome. However, some patients unexpectedly have a poor recovery of range of motion (ROM) after surgery. Objective factors such as initial diagnosis, pre- and intra-operative ROM, deltoid impairment or arm lengthening have previously been associated with anterior forward flexion (AFF). This study sought to determine if subjective pre-operative factors influence the rate and timing of ROM recovery after RSA...
August 8, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28782534/variation-in-adrenal-and-thyroid-hormones-with-life-history-stage-in-juvenile-northern-elephant-seals-mirounga-angustirostris
#16
J A Jelincic, M S Tift, D S Houser, D E Crocker
The classical approach to quantifying the impact of stressors on wildlife is through characterization of hormones associated with the generalized stress response. However, interpretation of hormone data can be difficult due to the range of natural variation within a species and potential confounds of individual and life-history variables. Blood adrenal and thyroid hormones were measured in 144 chemically immobilized yearling northern elephant seals (Mirounga angustirostris) to characterize variation between sexes and across semiannual haul-outs...
August 3, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28777999/perceptions-of-plagiarisers-the-influence-of-target-physical-attractiveness-transgression-severity-and-sex-on-attributions-of-guilt-and-punishment
#17
Viren Swami, Elizabeth Arthey, Adrian Furnham
The attractiveness-leniency effect (ALE) suggests that physically attractive targets are less likely to be perceived as guilty compared to less attractive targets. Here, we tested the ALE in relation to attributions of students who have committed plagiarism. British adults (N=165) were shown one of eight vignette-photograph pairings varying in target sex (female/male), physical attractiveness (high/low), and transgression severity (serious/minor), and provided attributions of guilt and severity of punishment...
August 1, 2017: Body Image
https://www.readbyqxmd.com/read/28776596/ocular-syphilis-the-re-establishment-of-an-old-disease
#18
J Wells, C Wood, A Sukthankar, N P Jones
PurposeTo present the patient profiles, clinical presentations and visual outcomes in those diagnosed with ocular syphilis, attending a subspecialist uveitis service in northern England over a 15-year period.Patients and methodsRetrospective observational case series of patients presenting between January 2002 and December 2016.ResultsA total of 50 eyes of 34 patients had intraocular inflammation due to syphilis. Of these, 94% were male, and 75% were men who had sex with men. Ten (29%), all male, were HIV-positive...
August 4, 2017: Eye
https://www.readbyqxmd.com/read/28776210/the-hnrnp-q-like-gene-is-retroinserted-into-the-b-chromosomes-of-the-cichlid-fish-astatotilapia-latifasciata
#19
Bianca O Carmello, Rafael L B Coan, Adauto L Cardoso, Erica Ramos, Bruno E A Fantinatti, Diego F Marques, Rogério A Oliveira, Guilherme T Valente, Cesar Martins
B chromosomes are dispensable elements observed in many eukaryotic species, including the African cichlid Astatotilapia latifasciata, which might have one or two B chromosomes. Although there have been many studies focused on the biology of these chromosomes, questions about the evolution, maintenance, and potential effects of these chromosomes remain. Here, we identified a variant form of the hnRNP Q-like gene inserted into the B chromosome of A. latifasciata that is characterized by a high copy number and intron-less structure...
August 3, 2017: Chromosome Research
https://www.readbyqxmd.com/read/28775377/objectively-measured-sedentary-time-and-physical-activity-and-associations-with-body-weight-gain-does-body-weight-determine-a-decline-in-moderate-and-vigorous-intensity-physical-activity
#20
U Ekelund, E Kolle, J Steene-Johannessen, K E Dalene, A K O Nilsen, S A Anderssen, B H Hansen
OBJECTIVES: High levels of physical activity may prevent the development of obesity. However, the magnitude and direction of the association between physical activity (PA) of various intensities, sedentary time and weight status remain unclear. Thus, we examined whether objectively measured sedentary time and physical activity independently predict gain in body weight, change in body weight and to examine the possibility of reverse causation. METHODS: We examined the prospective associations between sedentary time, PA and body weight (BW)...
August 4, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
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