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https://www.readbyqxmd.com/read/28922778/circulating-folate-vitamin-b6-and-methionine-in-relation-to-lung-cancer-risk-in-the-lung-cancer-cohort-consortium-lc3
#1
Anouar Fanidi, David C Muller, Jian-Min Yuan, Victoria L Stevens, Stephanie J Weinstein, Demetrius Albanes, Ross Prentice, Cynthia A Thomsen, Mary Pettinger, Qiuyin Cai, William J Blot, Jie Wu, Alan A Arslan, Anne Zeleniuch-Jacquotte, Marjorie L McCullough, Loic Le Marchand, Lynne R Wilkens, Christopher A Haiman, Xuehong Zhang, Jiali Han, Meir J Stampfer, Stephanie A Smith-Warner, Edward Giovannucci, Graham G Giles, Allison M Hodge, Gianluca Severi, Mikael Johansson, Kjell Grankvist, Arnulf Langhammer, Steinar Krokstad, Marit Næss, Renwei Wang, Yu-Tang Gao, Lesley M Butler, Woon-Puay Koh, Xiao-Ou Shu, Yong-Bing Xiang, Honglan Li, Wei Zheng, Qing Lan, Kala Visvanathan, Judith Hoffman Bolton, Per Magne Ueland, Øivind Midttun, Arve Ulvik, Neil E Caporaso, Mark Purdue, Regina G Ziegler, Neal D Freedman, Julie E Buring, I-Min Lee, Howard D Sesso, J Michael Gaziano, Jonas Manjer, Ulrika Ericson, Caroline Relton, Paul Brennan, Mattias Johansson
Background: Circulating concentrations of B vitamins and factors related to one-carbon metabolism have been found to be strongly inversely associated with lung cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The extent to which these associations are present in other study populations is unknown. Methods: Within 20 prospective cohorts from the National Cancer Institute Cohort Consortium, a nested case-control study was designed including 5364 incident lung cancer case patients and 5364 control subjects who were individually matched to case patients by age, sex, cohort, and smoking status...
January 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28915963/hepcidin-and-metallothioneins-as-molecular-base-for-sex-dependent-differences-in-clinical-course-of-experimental-autoimmune-encephalomyelitis-in-chronic-iron-overload
#2
Božena Ćurko-Cofek, Tanja Grubić Kezele, Vesna Barac-Latas
Multiple sclerosis is a chronic demyelinating disease of the central nervous system characterised by inflammatory and degenerative changes. It is considered that disease arises from the influence of environmental factors on genetically susceptible individuals. Recent researches, using magnetic resonance imaging, connected iron deposits in different brain regions with demyelinating process in multiple sclerosis patients. Although iron is an essential trace element important for many biological functions it could be harmful because iron excess can induce the production of reactive oxygen species, development of oxidative stress and lipid peroxidation which leads to demyelination...
September 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28912478/the-molecular-epidemiology-of-hiv-1-in-the-comunidad-valenciana-spain-analysis-of-transmission-clusters
#3
Juan Ángel Patiño-Galindo, Manoli Torres-Puente, María Alma Bracho, Ignacio Alastrué, Amparo Juan, David Navarro, María José Galindo, Dolores Ocete, Enrique Ortega, Concepción Gimeno, Josefina Belda, Victoria Domínguez, Rosario Moreno, Fernando González-Candelas
HIV infections are still a very serious concern for public heath worldwide. We have applied molecular evolution methods to study the HIV-1 epidemics in the Comunidad Valenciana (CV, Spain) from a public health surveillance perspective. For this, we analysed 1804 HIV-1 sequences comprising protease and reverse transcriptase (PR/RT) coding regions, sampled between 2004 and 2014. These sequences were subtyped and subjected to phylogenetic analyses in order to detect transmission clusters. In addition, univariate and multinomial comparisons were performed to detect epidemiological differences between HIV-1 subtypes, and risk groups...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28911174/sex-reversal-and-comparative-data-undermine-the-w-chromosome-and-support-z-linked-dmrt1-as-the-regulator-of-gonadal-sex-differentiation-in-birds
#4
Claire E Hirst, Andrew T Major, Katie L Ayers, Rosie J Brown, Mylene Mariette, Timothy B Sackton, Craig A Smith
The exact genetic mechanism regulating avian gonadal sex differentiation has not been completely resolved. The most likely scenario involves a dosage mechanism, whereby the Z-linked DMRT1 gene triggers testis development. However, the possibility still exists that the female-specific W chromosome may harbor an ovarian determining factor. In this study, we provide evidence that the universal gene regulating gonadal sex differentiation in birds is Z-linked DMRT1 and not a W-linked (ovarian) factor. Three candidate W-linked ovarian determinants are HINTW, female-expressed transcript 1 (FET1), and female-associated factor (FAF)...
September 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28911153/estrogen-receptor-%C3%AE-a-sex-dependent-predictor-of-aggressiveness-in-nonfunctioning-pituitary-adenomas-sstr-and-sex-hormone-receptor-distribution-in-nfpa
#5
Kristin Astrid Øystese, Olivera Casar-Borota, Kjersti Ringvoll Normann, Manuela Zucknick, Jens Petter Berg, Jens Bollerslev
Context: Nonfunctioning pituitary adenomas (NFPAs) are fairly common and require a multidisciplinary approach. Reliable markers of a clinically aggressive course are lacking. Medical treatment is not available, and transsphenoidal surgery is the preferred primary treatment. Objective: We aimed to characterize the somatostatin, estrogen, and progesterone receptor distribution for NFPAs and compare it with factors of tumor aggressiveness. Design: Tumor samples for immunohistochemistry (n = 145) and quantitative reverse transcription polymerase chain reaction (n = 106) analyses of somatostatin receptor (SSTR) 1, SSTR2, SSTR3, SSTR5, estrogen receptor α (ERα), and progesterone receptor (PR) were measured by immunoreactive score (IRS) and messenger RNA relative quantity and retrospectively compared with variables of aggressiveness...
September 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28911138/resetting-the-abnormal-circadian-cortisol-rhythm-in-adrenal-incidentaloma-patients-with-mild-autonomous-cortisol-secretion
#6
Miguel Debono, Robert F Harrison, Rita Chadarevian, Carole Gueroult, Jean-Louis Abitbol, John Newell-Price
Context: Adrenal incidentalomas (AIs) are found commonly on axial imaging. Around 30% exhibit autonomous cortisol secretion (ACS) associated with increased cardiovascular events and death. Objective: We hypothesized that AI/ACS patients have an abnormal cortisol rhythm that could be reversed by use of carefully timed short-acting cortisol synthesis blockade, with improvement in cardiovascular disease markers. Design, Setting, and Participants: In a phase 1/2a, prospective study (Eudract no...
September 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28903904/insights-of-sex-determination-and-differentiation-from-medaka-as-a-teleost-model
#7
Yi Kang, Gui-Jun Guan, Yun-Han Hong
The mechanisms of sex determination and differentiation in fish are highly divergent with a broad range of gonadal differentiation types from hermaphroditism to gonochorism. Multiple triggers regulate the process of sexual differentiation including genetic or environmental factors (temperature, light, hormones and/or pH value, etc.). In recent years, with the advances of molecular technologies and genetic engineering approaches, there are significant breakthroughs in identifying the master genes of vertebrate sex determination and differentiation...
June 20, 2017: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/28902977/contraceptive-sterilization-introducing-a-couple-perspective-to-examine-sociodemographic-differences-in-use
#8
Mieke C W Eeckhaut
CONTEXT: Most studies of contraceptive use have relied solely on the woman's perspective, but because men's attitudes and preferences are also important, analytic approaches based on couples should also be explored. METHODS: Data from the 2006-2010 and 2011-2013 rounds of the National Survey of Family Growth yielded a sample of 4,591 men and women who were married or cohabiting with an opposite-sex partner and who had completed their intended childbearing. Respondents' reports of both their own and their partners' characteristics and behaviors were employed in two sets of analyses examining educational and racial and ethnic differences in contraceptive use: an individualistic approach (using multinomial logistic regression) and a couple approach (using multinomial logistic diagonal reference models)...
September 2017: Perspectives on Sexual and Reproductive Health
https://www.readbyqxmd.com/read/28895797/neuroendocrine-disruption-of-organizational-and-activational-hormone-programming-in-poikilothermic-vertebrates
#9
Cheryl S Rosenfeld, Nancy D Denslow, Edward F Orlando, Juan Manuel Gutierrez-Villagomez, Vance L Trudeau
In vertebrates, sexual differentiation of the reproductive system and brain is tightly orchestrated by organizational and activational effects of endogenous hormones. In mammals and birds, the organizational period is typified by a surge of sex hormones during differentiation of specific neural circuits; whereas activational effects are dependent upon later increases in these same hormones at sexual maturation. Depending on the reproductive organ or brain region, initial programming events may be modulated by androgens or require conversion of androgens to estrogens...
2017: Journal of Toxicology and Environmental Health. Part B, Critical Reviews
https://www.readbyqxmd.com/read/28895061/valvular-heart-disease-in-women-differential-remodeling-and-response-to-new-therapies
#10
REVIEW
Jaya Chandrasekhar, George Dangas, Roxana Mehran
In the United States, valvular heart disease (VHD) has a prevalence of 2.5%, most commonly presenting as aortic stenosis (AS) or mitral valve regurgitation (MR) and increasingly observed to be of a degenerative etiology. Women frequently have latent symptoms despite significant disease, and it is therefore pertinent to consider both clinical symptoms and imaging findings for decision-making on treatment. Indeed, significant advances have been made in noninvasive imaging allowing for more accurate diagnosis and disease prognostication...
September 11, 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28889782/sex-related-hormone-receptor-in-laryngeal-squamous-cell-carcinoma-correlation-with-androgen-estrogen-%C3%A9-and-prolactin-receptor-expression-and-influence-of-prognosis
#11
Mengjia Fei, Jingwen Zhang, Jiaqing Zhou, Yanan Xu, Jiadong Wang
BACKGROUND: The expression and function of androgen receptors (AR) and estrogen receptor alpha (ER-ɑ) in laryngeal squamous cell carcinoma (LSCC) have remained controversial for decades. Prolactin receptor (PRLR) is a sex-related hormone, that has been rarely documented in terms of expression or function compared with data on other hormone receptors in laryngeal carcinoma. METHODS: This study reports on immunohistochemical and reverse transcription-polymerase chain reaction (RT-PCR) analysis of tumour tissue and adjacent normal tissue in 96 patients with LSCC (82 males and 14 females)...
September 11, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28888327/vicarious-social-defeat-stress-induces-depression-related-outcomes-in-female-mice
#12
Sergio D Iñiguez, Francisco J Flores-Ramirez, Lace M Riggs, Jason B Alipio, Israel Garcia-Carachure, Mirella A Hernandez, David O Sanchez, Mary Kay Lobo, Peter A Serrano, Stephen H Braren, Samuel A Castillo
BACKGROUND: Stress is a prevailing risk factor for mood-related illnesses, wherein women represent the majority of those affected by major depression. Despite the growing literature suggesting that affective disorders can arise after a traumatic event is vicariously experienced, this relationship remains understudied in female subjects at the preclinical level. Thus, the objective of the current investigation was to examine whether exposure to emotional and/or psychological stress (ES) mediates depression-related outcomes in female mice...
July 29, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28880858/vital-signs-recent-trends-in-stroke-death-rates-united-states-2000-2015
#13
Quanhe Yang, Xin Tong, Linda Schieb, Adam Vaughan, Cathleen Gillespie, Jennifer L Wiltz, Sallyann Coleman King, Erika Odom, Robert Merritt, Yuling Hong, Mary G George
INTRODUCTION: The prominent decline in U.S. stroke death rates observed for more than 4 decades has slowed in recent years. CDC examined trends and patterns in recent stroke death rates among U.S. adults aged ≥35 years by age, sex, race/ethnicity, state, and census region. METHODS: Trends in the rates of stroke as the underlying cause of death during 2000-2015 were analyzed using data from the National Vital Statistics System. Joinpoint software was used to identify trends in stroke death rates, and the excess number of stroke deaths resulting from unfavorable changes in trends was estimated...
September 8, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28877966/t-cell-mediation-of-pregnancy-analgesia-affecting-chronic-pain-in-mice
#14
Sarah F Rosen, Boram Ham, Shannon Drouin, Nadia Boachie, Anne-Julie Chabot-Dore, Jean-Sebastien Austin, Luda Diatchenko, Jeffrey S Mogil
It has been consistently reported that many female chronic pain sufferers have an attenuation of symptoms during pregnancy. Rats display increased pain tolerance during pregnancy, due to an increase in opioid receptors in the spinal cord. These past studies did not consider the role of non-neuronal cells, now appreciated to play an important role in chronic pain processing. Using an inflammatory (complete Freund's adjuvant) or neuropathic (spared nerve injury) model of persistent pain, we observe that young adult female mice in early pregnancy switch from a micgrolia-independent to a microglia-dependent pain hypersensitivity mechanism...
September 6, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28875609/epidemiological-correlation-between-fecal-adenovirus-subgroups-and-pediatric-intussusception-in-korea
#15
Jooyoung Jang, Yeoun Joo Lee, Joon Sung Kim, Ju Young Chung, Soohee Chang, Kunsong Lee, Byung Ho Choe, Suk Jin Hong, Jae Seok Song, Kie Young Park
We investigated the adenoviral etiology and seasonal epidemic trends in intussusception and each adenoviral subgroup. Also we confirmed whether we can use the adenovirus data of Acute Infectious Agents Laboratory Surveillance Report (AIALSR) as an epidemic predictor of intussusception. Patients with intussusception (n = 126), < 5 years old, were enrolled and matched by age and sex with controls suffering acute gastroenteritis without intussusception (n = 106), all recruited at 8 centers. All fecal specimens were assayed for adenovirus, including subgroups A, B, C, E, and F, with reverse transcriptase-polymerase chain reaction (RT-PCR)...
October 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28874577/stachel-independent-modulation-of-gpr56-adgrg1-signaling-by-synthetic-ligands-directed-to-its-extracellular-region
#16
Gabriel S Salzman, Shu Zhang, Ankit Gupta, Akiko Koide, Shohei Koide, Demet Araç
Adhesion G protein-coupled receptors (aGPCRs) play critical roles in diverse biological processes, including neurodevelopment and cancer progression. aGPCRs are characterized by large and diverse extracellular regions (ECRs) that are autoproteolytically cleaved from their membrane-embedded signaling domains. Although ECRs regulate receptor function, it is not clear whether ECRs play a direct regulatory role in G-protein signaling or simply serve as a protective cap for the activating "Stachel" sequence. Here, we present a mechanistic analysis of ECR-mediated regulation of GPR56/ADGRG1, an aGPCR with two domains [pentraxin and laminin/neurexin/sex hormonebinding globulin-like (PLL) and G protein-coupled receptor autoproteolysis-inducing (GAIN)] in its ECR...
September 5, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28871259/syphilis-infection-differentially-regulates-the-phenotype-and-function-of-%C3%AE-%C3%AE-t-cells-in-hiv-1-infected-patients-depends-on-the-hiv-1-disease-stage
#17
Zhen Li, Xiaofan Lu, Zhiliang Hu, Zhenwu Luo, Wei Jiang, Hao Wu, Yanqing Gao, Junling Yan, Qiuyue Zhang, Aixin Song, Xiaojie Huang, Danlei Mou, Bin Su, Tong Zhang
A rapidly escalating outbreak of syphilis infection has been affected men who have sex with men, particularly those with HIV-1 infection. γδ T cells are unconventional immune cells with two main subsets, Vδ1 T cells and Vδ2 T cells, which possess a combination of innate and adaptive immune features allowing them against HIV-1. However, whether syphilis infection affects the phenotype and function of γδ T cells in HIV-1-infected patients remains unclear, especially in acute HIV-1 infection (AHI). In this study, we enrolled 57 HIV-1-infected patients (24 with HIV-1 infection only and 33 coinfected with syphilis) from an acute HIV-1-infected cohort in Beijing (PRIMO)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28871239/arginine-vasopressin-effects-on-subjective-judgments-and-neural-responses-to-same-and-other-sex-faces-in-men-and-women
#18
James K Rilling, Ting Li, Xiangchuan Chen, Pritam Gautam, Ebrahim Haroon, Richmond R Thompson
Arginine vasopressin (AVP) influences social and emotional behaviors across a wide range of species. In humans, intranasal AVP has been previously shown to alter physiological responses to and subjective judgments of same-sex faces in both men and women. The present study attempted to elucidate the neural mechanism for these effects by randomizing 40 healthy men and 40 healthy women to treatment with either 40 IU intranasal AVP or a saline placebo approximately 30 min before imaging their brain function with fMRI as they viewed same and other-sex faces...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28870548/corticosteroid-therapy-and-severity-of-vasogenic-edema-in-posterior-reversible-encephalopathy-syndrome
#19
Neal S Parikh, Andrew D Schweitzer, Robert J Young, Ashley E Giambrone, John Lyo, Sasan Karimi, Anna Knobel, Ajay Gupta, Babak B Navi
BACKGROUND: Posterior reversible encephalopathy syndrome (PRES) is a variable cerebrovascular syndrome associated with hypertension and autoregulatory failure. Steroids have been reported to both precipitate and treat PRES. We sought to determine the prevalence of steroid therapy at the time of PRES and to assess the relationship between steroid therapy and extent of vasogenic edema. METHODS: We performed a retrospective review of radiology reports between 2008 and 2014 from two academic medical centers to identify cases of PRES...
September 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28867265/implantable-cardioverter-defibrillator-implantation-rates-after-out-of-hospital-cardiac-arrest-are-the-rates-guideline-concordant
#20
Edwin C Ho, Sheldon Cheskes, Paul Angaran, Laurie J Morrison, Theresa Aves, Cathy Zhan, Dennis T Ko, Paul Dorian
BACKGROUND: Clinical practice guidelines recommend implantable cardioverter defibrillators (ICDs) for the secondary prevention of sudden death after a cardiac arrest not from a reversible cause, but "real world" implantation rates are not well described. METHODS: Adults with out of hospital cardiac arrest attended by Emergency Medical Services are captured in the Toronto Regional RescuNET database. We analyzed those who survived to hospital discharge and collected data on age, sex, initial rhythm, ST-elevation myocardial infarction (STEMI) on presenting electrocardiogram (ECG), in-hospital revascularization, neurologic status (Modified Rankin Scale [MRS]) at discharge, and admission hospital type...
August 23, 2017: Canadian Journal of Cardiology
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