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https://www.readbyqxmd.com/read/28440726/expression-of-c-type-lectin-receptor-mrna-in-chronic-otitis-media-with-cholesteatoma
#1
Sang Hoon Kim, Seung-Ho Han, Jae Yong Byun, Moon Suh Park, Young Il Kim, Seung Geun Yeo
CONCLUSIONS: The levels of expression of various C-type lectin receptors (CLRs) messenger ribo nucleic acids (mRNAs) were significantly higher in cholesteatomas than in normal skin, suggesting that these CLRs may be involved in the pathogenesis of cholesteatoma. OBJECTIVES: Altered expression of pattern recognition receptors may be associated with immune responses in patients with cholesteatoma. This study assessed the levels of expression of CLR mRNAs in normal skin and in cholesteatoma...
June 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28440454/microrna%C3%A2-336-directly-targets-sox%C3%A2-2-in-osteosarcoma-to-inhibit-tumorigenesis
#2
Yong Cao, Tianding Wu, Dongzhe Li, Jianzhong Hu, Hongbin Lu
Previous evidence has suggested that microRNAs (miRNAs or miRs), which belong to a class of non‑coding RNAs, shape cellular processes by regulating gene expression. Abnormal expression of miRNAs has been associated with tumorigenesis in multiple cancers. However, the function of miR‑336 in osteosarcoma (OS) remains unknown. The experimental procedures used in the present study included flow cytometry, reverse transcription‑quantitative polymerase chain reaction, luciferase reporter assay, invasion assay, western blot analysis and in vivo implantation...
April 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28440204/apixaban-metabolism-pharmacologic-properties-and-drug-interaction
#3
Peter Kubisz, Lucia Stanciakova, Miroslava Dobrotova, Matej Samos, Marian Mokan, Jan Stasko
BACKGROUND: Apixaban is an oral, potent, highly selective, reversible and direct inhibitor of activated coagulation factor X, that is the end point of the intrinsic and extrinsic coagulation pathway. Additionally, apixaban has the capacity to indirectly inhibit thrombin-induced platelet aggregation. This new oral anticoagulant represents an immediate-release form of peroral drug with quick dissolution, linear pharmacokinetics, good bioavailability and rapid onset and offset of action...
April 24, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28439127/diversity-and-evolution-of-sex-determination-systems-in-terrestrial-isopods
#4
Thomas Becking, Isabelle Giraud, Maryline Raimond, Bouziane Moumen, Christopher Chandler, Richard Cordaux, Clément Gilbert
Sex determination systems are highly variable in many taxa, sometimes even between closely related species. Yet the number and direction of transitions between these systems have seldom been characterized, and the underlying mechanisms are still poorly understood. Here we generated transcriptomes for 19 species of terrestrial isopod crustaceans, many of which are infected by Wolbachia bacterial endosymbionts. Using 88 single-copy orthologous genes, we reconstructed a fully resolved and dated phylogeny of terrestrial isopods...
April 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28436761/androgen-and-estrogen-shifts-in-men-before-and-after-bariatric-surgery-and-links-to-vitamins-and-trace-elements
#5
Alberto Rosenblatt, Joel Faintuch, Ivan Cecconello
Androgens and estrogens play a key role regarding sexual life and reproduction. Along with hypotestosteronemia, obese men exhibit a 2-fold increase in estradiol concentration, adversely infl uencing these parameters. Estrogens and adipokines also infl uence bone metabolism, exerting a direct effect on vitamin D, calcium homeostasis and bone health. Bariatric procedures normalize some sex hormones, and may reverse several obesity-related conditions. Estrogens levels may remain elevated postoperatively, and despite its protective effect on the skeleton, bariatric patients are more prone to fractures when compared to the general population...
April 24, 2017: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
https://www.readbyqxmd.com/read/28431163/an-evaluation-of-the-human-relevance-of-the-lung-tumors-observed-in-female-mice-treated-with-permethrin-based-on-mode-of-action
#6
Tomoya Yamada, Miwa Kondo, Kaori Miyata, Keiko Ogata, Masahiko Kushida, Kayo Sumida, Satoshi Kawamura, Thomas G Osimitz, Brian G Lake, Samuel M Cohen
Permethrin increased the incidence of bronchiolo-alveolar adenomas in female mice but not male mice or female or male rats. Studies were conducted to determine whether permethrin has mitogenic activity in Club cells in mouse lung as the basis for the mode of action (MOA) for the lung adenoma induction. Several short term experiments focusing on time-course, dose-response, reversibility, sex difference, strain difference, and species difference were evaluated for Club cell proliferation and morphology. The findings demonstrated that permethrin slightly and continuously enhanced Club cell proliferation at tumor-associated dose levels in female mice, but did not increase proliferation in male mice or in female rats...
April 18, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28430795/igm-antibodies-to-oxidized-phosphatidylserine-as-protection-markers-in-cardiovascular-disease-among-60-year-olds
#7
Johan Frostegård, Jun Su, Sudhir Sing, Xiang Hua, Max Vikström, Karin Leander, Bruna Gigante, Ulf de Faire, Anna G Frostegård
OBJECTIVE: Phosphatidylserine is exposed on apoptotic cells and is prone to oxidation (OxPS). Here we analyze the association of IgM antibodies against OxPS (anti-OxPS) with the risk of cardiovascular disease (CVD). METHODS: Among sixty-year olds from Stockholm County in Sweden, previously screened for cardiovascular risk factors (2039 men, 2193 women), there were 210 incident CVD-cases identified during a 5-year follow-up. Using a nested case-control design, 622 age- and sex-matched controls were selected...
2017: PloS One
https://www.readbyqxmd.com/read/28429107/psychosocial-factors-at-work-and-sleep-problems-a-longitudinal-study-of-the-general-working-population-in-norway
#8
Håkon A Johannessen, Tom Sterud
PURPOSE: A growing number of longitudinal studies report associations between adverse psychosocial factors at work and sleep problems. However, the evidence regarding the direction of these associations and the effects of changes in exposure across time is limited. This study examined the plausibility of normal, reverse, and reciprocal associations between ten psychosocial factors at work and sleep problems. In addition, we analyzed if reduced exposure across time had the anticipated result of reducing the risk of sleep problems...
April 20, 2017: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/28427378/assessment-of-cardiac-function-in-children-with-congenital-adrenal-hyperplasia-a-case-control-study-in-cameroon
#9
J Tony Nengom, S Sap Ngo Um, D Chelo, R Mbono Betoko, J Boombhi, F Mouafo Tambo, A Chiabi, S Kingue, P Koki Ndombo
BACKGROUND: High level of androgens found in congenital adrenal hyperplasia (CAH) seems to have a deleterious effect on heart function. We therefore evaluate cardiac function of children with CAH in comparison with a healthy group. METHODS: We carried out a case-control study in the single endocrinology unit of the Mother and Child Center of Chantal Biya's Foundation. Cases were matched for age and genotypic sex to 2 healthy controls. We analyzed the ejection fraction (LVEF), fractional shortening and left ventricular mass; output and cardiac index; E and A waves velocities, E/A ratio and the mitral deceleration time and diameter of the left atrium; tricuspid annular plane systolic excursion and pulmonary artery systolic pressure were also measured...
April 20, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28424461/a-lack-of-coordination-between-sister-chromatids-segregation-and-cytokinesis-in-the-oocytes-of-b6-y-tir-xy-sex-reversed-female-mice
#10
Jia-Qiao Zhu, Seang Lin Tan, Teruko Taketo
The B6.Y(TIR) (XY) mouse develops bilateral ovaries despite the expression of the testis-determining gene Sry during gonadal differentiation. We reported that the oocytes of the XY female are defective in their cytoplasm, resulting in a failure in the second meiotic division after activation or fertilization in vitro. However, the mechanism of meiotic failure or the cause of infertility remained to be clarified. In the present study, we obtained mature oocytes from XY females by superovulation and confirmed that these oocytes also fail in zygotic development...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28419480/characterization-of-neutropenia-in-advanced-cancer-patients-following-palbociclib-treatment-using-a-population-pharmacokinetic-pharmacodynamic-modeling-and-simulation-approach
#11
Wan Sun, Peter J O'Dwyer, Richard S Finn, Ana Ruiz-Garcia, Geoffrey I Shapiro, Gary K Schwartz, Angela DeMichele, Diane Wang
Neutropenia is the most commonly reported hematologic toxicity following treatment with palbociclib, a cyclin-dependent kinase 4/6 inhibitor approved for metastatic breast cancer. Using data from 185 advanced cancer patients receiving palbociclib in 3 clinical trials, a pharmacokinetic-pharmacodynamic model was developed to describe the time course of absolute neutrophil count (ANC) and quantify the exposure-response relationship for neutropenia. These analyses help in understanding neutropenia associated with palbociclib and its comparison with chemotherapy-induced neutropenia...
April 18, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28410357/donor-endothelial-cell-count-does-not-correlate-with-descemet-stripping-automated-endothelial-keratoplasty-transplant-survival-after-2-years-of-follow-up
#12
Ivan O Potapenko, Branka Samolov, Margareta Claesson Armitage, Berit Byström, Jesper Hjortdal
PURPOSE: To analyze the influence of low endothelial cell density (ECD) of donor cornea tissue, donor age, and sex on the transplant survival rate after Descemet stripping automated endothelial keratoplasty (DSAEK). METHODS: Graft ECD, age, and sex of donors used for DSAEK (n = 1789) during 7 years (2007-2014) in 4 Scandinavian hospitals were assessed for potential association with transplant survival at 2 years of follow-up using a Cox regression model correcting for confounding factors...
April 12, 2017: Cornea
https://www.readbyqxmd.com/read/28400722/sex-differences-in-the-physiological-and-behavioral-effects-of-chronic-oral-methylphenidate-treatment-in-rats
#13
Lisa S Robison, Michalis Michaelos, Jason Gandhi, Dennis Fricke, Erick Miao, Chiu-Yim Lam, Anthony Mauceri, Melissa Vitale, Junho Lee, Soyeh Paeng, David E Komatsu, Michael Hadjiargyrou, Panayotis K Thanos
Methylphenidate (MP) is a psychostimulant prescribed for Attention Deficit Hyperactivity Disorder. Previously, we developed a dual bottle 8-h-limited-access-drinking-paradigm for oral MP treatment of rats that mimics the pharmacokinetic profile of treated patients. This study assessed sex differences in response to this treatment. Male and female Sprague Dawley rats were assigned to one of three treatment groups at 4 weeks of age (n = 12/group): Control (water), low dose (LD) MP, and high dose (HD) MP. Rats drank 4 mg/kg MP (LD) or 30 mg/kg MP (HD) during the first hour, and 10 mg/kg (LD) or 60 mg/kg MP (HD) for the remaining 7 h each day...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28400332/sexual-dimorphic-expression-of-dnd-in-germ-cells-during-sex-reversal-and-its-requirement-for-primordial-germ-cell-survival-in-protogynous-hermaphroditic-grouper
#14
Zhi-Hui Sun, Li Zhou, Zhi Li, Xiao-Chun Liu, Shui-Sheng Li, Yang Wang, Jian-Fang Gui
Dead end (dnd), vertebrate-specific germ cell marker, had been demonstrated to be essential for primordial germ cell (PGC) migration and survival, and the link between PGC number and sex change had been revealed in some teleost species, but little is known about dnd in hermaphroditic vertebrates. In the present study, a protogynous hermaphroditic orange-spotted grouper (Epinephelus coioides) dnd homologue (Ecdnd) was identified and characterized. Quantitative real-time PCR and in situ hybridization analysis revealed a dynamic and sexually dimorphic expression pattern in PGCs and germ cells of gonads...
April 8, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28398516/functional-analysis-of-nuclear-estrogen-receptors-ners-in-zebrafish-reproduction-by-genome-editing-approach
#15
Huijie Lu, Yong Cui, Liwen Jiang, Wei Ge
Estrogens signal through both nuclear and membrane receptors with most reported effects being mediated via the nuclear estrogen receptors (nERs). Although much work has been reported on nERs in the zebrafish, there is a lack of direct genetic evidence for their functional roles and importance in reproduction. To address this issue, we undertook this study to disrupt all three nERs in the zebrafish, namely esr1 (ERα), esr2a (ERβII) and esr2b (ERβI), by genome-editing technology CRISPR/Cas9. Using this loss-of-function genetic approach, we successfully created three mutant zebrafish lines with each nER knocked out...
April 10, 2017: Endocrinology
https://www.readbyqxmd.com/read/28398156/a-simulated-heat-wave-has-diverse-effects-on-immune-function-and-oxidative-physiology-in-the-corn-snake-pantherophis-guttatus
#16
Z R Stahlschmidt, S S French, A Ahn, A Webb, M W Butler
Animals will continue to encounter increasingly warm environments, including more frequent and intense heat waves. Yet the physiological consequences of heat waves remain equivocal, potentially because of variation in adaptive plasticity (reversible acclimation) and/or aspects of experimental design. Thus, we measured a suite of physiological variables in the corn snake (Pantherophis guttatus) after exposure to field-parameterized, fluctuating temperature regimes (moderate temperature and heat wave treatments) to address two hypotheses: (1) a heat wave causes physiological stress, and (2) thermal performance of immune function exhibits adaptive plasticity in response to a heat wave...
July 2017: Physiological and Biochemical Zoology: PBZ
https://www.readbyqxmd.com/read/28397607/sex-reversal-and-analyses-of-possible-involvement-of-sex-steroids-in-scallop-gonadal-development-in-newly-established-organ-culture-systems
#17
Ayano Otani, Tadaaki Nakajima, Tomomi Okumura, Shiro Fujii, Yasuhiro Tomooka
Many molluscs perform sex reversal, and sex hormones may be involved in the process. In adult scallops, Patinopecten yessoensis, gonadotropin releasing hormone and 17β-estradiol (E2) are involved in male sexual maturation, however, little is known about the effects of E2 and testosterone (T) on the gonadal differentiation in young scallops. In the present study, scallop gonadal development was analyzed to determine the sex reversal stage in Funka bay, and effects of E2 and T were examined. In Funka bay, almost all scallops were male at month 12...
April 2017: Zoological Science
https://www.readbyqxmd.com/read/28396913/geographical-variation-in-sexual-behavior-and-body-traits-in-a-sex-role-reversed-wolf-spider
#18
Fedra Bollatti, Virginia Garcia Diaz, Alfredo V Peretti, Anita Aisenberg
Mating partners need to recognize, assess each other, and exchange information through behavioral events that occur before, during, and after mating. Sexual signals, as well as life history traits, are influenced by selective pressures and environmental factors that can vary across distant geographical areas. Allocosa senex is a sand-dwelling wolf spider which constructs burrows along the sandy coasts of Argentina, Brazil, and Uruguay. Females are the mobile sex that searches for males and initiates courtship...
June 2017: Die Naturwissenschaften
https://www.readbyqxmd.com/read/28393353/individual-heterogeneity-determines-sex-differences-in-mortality-in-a-monogamous-bird-with-reversed-sexual-dimorphism
#19
Fernando Colchero, Alix Eva Aliaga, Owen Jones, Dalia Amor Conde
1.Sex differences in mortality are pervasive in vertebrates, and usually result in shorter life spans in the larger sex, although the underlying mechanisms are still unclear. On the other hand, differences in frailty among individuals (i.e. individual heterogeneity), can play a major role in shaping demographic trajectories in wild populations. The link between these two processes has seldom been explored. 2.We used Bayesian survival trajectory analysis to study age-specific mortality trajectories in the Eurasian sparrowhawk (Accipiter nisus), a monogamous raptor with reversed sexual size dimorphism...
April 9, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28390266/relationship-between-serum-25-hydroxyvitamin-d-and-inflammatory-cytokines-in-paediatric-sickle-cell-disease
#20
Samuel Ademola Adegoke, Olufemi Samuel Smith, Adekunle D Adekile, Maria Stella Figueiredo
BACKGROUND: Alteration in the concentration of inflammatory cytokines may contribute to pathogenesis in sickle cell anaemia (SCA). Vitamin D may suppress pro-inflammatory cytokines and enhance anti-inflammatory cytokines. OBJECTIVE: To compare steady state levels of pro-and anti-inflammatory cytokines of Nigerian SCA children with age- and sex-matched healthy controls, and determine the relationship with 25-hydroxyvitamin-D (25-OHD). Effects of three months of vitamin D supplementation on cytokines of SCA children with suboptimal 25-OHD were also evaluated...
April 5, 2017: Cytokine
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