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https://www.readbyqxmd.com/read/29777715/association-between-plasma-ceramides-and-inducible-myocardial-ischemia-in-patients-with-established-or-suspected-coronary-artery-disease-undergoing-myocardial-perfusion-scintigraphy
#1
Alessandro Mantovani, Stefano Bonapace, Gianluigi Lunardi, Matteo Salgarello, Clementina Dugo, Guido Canali, Christopher D Byrne, Stefania Gori, Enrico Barbieri, Giovanni Targher
BACKGROUND: Recent studies have suggested that specific plasma ceramides are independently associated with major adverse cardiovascular events in patients with coronary artery disease (CAD), but it is currently unknown whether plasma ceramide levels are associated with stress-induced reversible myocardial ischemia. METHODS: We measured six previously identified high-risk plasma ceramide molecules [Cer(d18:1/16:0), Cer(d18:1/18:0), Cer(d18:1/20:0), Cer(d18:1/22:0), Cer(d18:1/24:0), and Cer(d18:1/24:1)] in 167 consecutive patients with established or suspected CAD who underwent either exercise or dypiridamole myocardial perfusion scintigraphy (MPS) for various clinical indications...
May 16, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29776798/changes-in-chlamydia-prevalence-and-duration-of-infection-estimated-from-testing-and-diagnosis-rates-in-england-a-model-based-analysis-using-surveillance-data-2000-15
#2
Joanna Lewis, Peter J White
BACKGROUND: Chlamydia screening programmes have been implemented in several countries, but the effects of screening on incidence, prevalence, and reproductive sequelae remain unclear. In England, despite increases in testing with the rollout of the National Chlamydia Screening Programme (NCSP; 2003-08), prevalence estimated in 10-yearly population-based surveys was similar before (1999-2001) and after (2010-12) the programme. However, the precision of these previous estimates was limited by the low numbers of infections...
May 15, 2018: Lancet. Public Health
https://www.readbyqxmd.com/read/29775019/-the-expression-and-clinical-progression-of-androgen-estrogen-and-prolactin-receptor-in-laryngeal-squamous-cell-carcinoma
#3
M J Fei, Y N Xu, J D Wang
Objective: The aim of this study is to analyze the different expression and function of androgen receptors (AR) and estrogen receptor (ER-α) in laryngeal squamous cell carcinoma (LSCC). In combination with the expression of prolactin receptor (PRLR), we analyzed the prognostic impact of three receptors on the laryngeal carcinoma. Method: In this study, immunohistochemistry and reverse transcription polymerase chain reaction (RT-PC) analysis were performed on the tumor tissues and adjacent normal tissues in 112 LSCC patients (95 males and 17 females)...
February 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29765228/role-of-mir-613-as-a-tumor-suppressor-in-glioma-cells-by-targeting-sox9
#4
Qiuling Sang, Xuejuan Liu, Daju Sun
Background and objectives: MicroRNA-613 (miR-613), a novel cancer-related microRNA, has been shown to be responsible for the inhibition of tumor development and progression in various cancers. We aimed to investigate the biological function and regulatory mechanisms of miR-613 in gliomas. Materials and methods: miR-613 expression were detected by qRT-PCR assays in glioma tissues and cell lines. Cell Counting Kit-8 (CCK-8) assay, colony formation analysis, wound healing and transwell invasion assays were performed to evaluate cell proliferation, colony formation, migration and invasion abilities...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29760778/loss-of-dmrt1-gene-in-a-mos-45-xy-9-8-46-xy-r-9-29-47-xy-idic-r-9-%C3%A3-2-1-46-xy-idic-r-9-1-46-xy-1-female-presenting-with-short-stature
#5
Bagas A Marsudi, Hannie Kartapradja, Chrysantine Paramayuda, Jose R L Batubara, Alida R Harahap, Nanis S Marzuki
Background: A 46,XY sex reversal syndrome is characterized by discordant genetic and phenotypic sex, leading to normal external female genitalia, undeveloped gonads and presence of Müllerian structures in an otherwise 46,XY individual. Chromosome 9pter aberrations, such as ring chromosome have been reported to cause 46,XY disorders of sex development (DSD), due to involvement of DMRT1 gene located at the 9p24.3 region. Case presentation: This study presents a unique case of a 12-year-old female with mos 46,XY, (r)9[31]/45,XY,-9[9] karyotype, presenting with intellectual disability and short stature, mimicking Turner syndrome...
2018: Molecular Cytogenetics
https://www.readbyqxmd.com/read/29760567/mir-497-5p-mir-195-5p-and-mir-455-3p-function-as-tumor-suppressors-by-targeting-htert-in-melanoma-a375-cells
#6
Li Chai, Xiao-Jing Kang, Zhen-Zhu Sun, Ming-Feng Zeng, Shi-Rong Yu, Yuan Ding, Jun-Qin Liang, Ting-Ting Li, Juan Zhao
Background: hTERT gene plays an important role in melanoma, although the specific mechanism involved is unclear. The aim of this study was to screen and identify the relative miRNAs with the regulation of hTERT in melanoma. Materials and methods: Quantitative real-time polymerase chain reaction (q-PCR) and immunohistochemistry were performed to detect hTERT mRNA and protein expression in 36 formalin-fixed paraffin-embedded melanoma tissues and 36 age- and sex-matched pigmented nevi cases, respectively...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29760184/structural-and-functional-rescue-of-chronic-metabolically-stressed-optic-nerves-through-respiration
#7
Mohammad Harun-Or-Rashid, Nate Pappenhagen, Peter G Palmer, Matthew A Smith, Victoria Gevorgyan, Gina N Wilson, Samuel D Crish, Denise M Inman
Axon degeneration can arise from metabolic stress, potentially a result of mitochondrial dysfunction or lack of appropriate substrate input. In this study, we investigated whether the metabolic vulnerability observed during optic neuropathy in the DBA/2J (D2) model of glaucoma is due to dysfunctional mitochondria or impaired substrate delivery to axons, the latter based on our observation of significantly decreased glucose and monocarboxylate transporters in D2 optic nerve (ON), human ON, and mice subjected to acute glaucoma injury...
May 14, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29758268/pathogenesis-of-keratoconus-the-intriguing-therapeutic-potential-of-prolactin-inducible-protein
#8
REVIEW
Rabab Sharif, Sashia Bak-Nielsen, Jesper Hjortdal, Dimitrios Karamichos
Keratoconus (KC) is the most common ectatic corneal disease, with clinical findings that include discomfort, visual disturbance and possible blindness if left untreated. KC affects approximately 1:400 to 1:2000 people worldwide, including both males and females. The aetiology and onset of KC remains a puzzle and as a result, the ability to treat or reverse the disease is hampered. Sex hormones are known to play a role in the maintenance of the structure and integrity of the human cornea. Hormone levels have been reported to alter corneal thickness, curvature, and sensitivity during different times of menstrual cycle...
May 11, 2018: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/29756454/discordance-in-drug-resistance-mutations-between-blood-plasma-and-semen-or-rectal-secretion-among-newly-diagnosed-hiv-1-infected-thai-msm
#9
Akarin Hiransuthikul, Rapeeporn Wongkanya, Sunee Sirivichayakul, Deondara Trachunthong, Thanthip Sungsing, Tippawan Pankam, Praphan Phanuphak, Nittaya Phanuphak
HIV-1 infection is most commonly transmitted by sexual contact across mucosal surfaces. Information on concordance in drug resistance profile between blood plasma and anogenital compartments in resource-limited settings is limited. We aimed to determine discordances in genotypic drug resistance-associated mutations (DRAMs) between blood plasma and semen or rectal secretions among newly diagnosed, antiretroviral therapy (ART)-naïve, HIV-1-infected Thai men who have sex with men (MSM). Blood plasma, semen, and rectal secretions of HIV-1-infected Thai MSM enrolled from the Test and Treat cohort were tested for genotypic mutations in the reverse transcriptase and protease genes...
May 14, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29755708/growth-and-endocrine-function-in-tunisian-thalassemia-major-patients
#10
Naouel Guirat Dhouib, Monia Ben Khaled, Monia Ouederni, Habib Besbes, Ridha Kouki, Fethi Mellouli, Mohamed Bejaoui
β-thalassemia major (β-TM) is among the most common hereditary disorders imposing high expenses on health-care system worldwide. The patient's survival is dependent on lifetime blood transfusion which leads to iron overload and its toxicity in various organs including endocrine glands. This article provides an overview of endocrine disorders in beta-TM patients. This single center investigation enrolled 28 β-TM patients (16 males, 12 females) regularly transfused with packed red cell since early years of life...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29750839/association-between-body-mass-index-and-the-risk-of-hip-fracture-by-sex-and-age-a-prospective-cohort-study
#11
Se Hwa Kim, Sang-Wook Yi, Jee-Jeon Yi, Yoo Mee Kim, Young Jun Won
The association between body mass index (BMI) and hip fracture may differ by ethnic group. We examined the association between BMI and hip fracture according to sex and age, and to identify BMI ranges associated with the lowest risk in Korean men and women. We followed-up 288,068 Korean adults (age, 50-80 years), who underwent health examinations in 2002-2003, to 2013; we examined national hospital discharge records. Hazard ratios (HRs) were calculated using Cox proportional hazard models after adjusting for confounders...
May 11, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29750331/salivary-gland-protective-regulatory-t-cell-dysfunction-underlies-female-specific-sialadenitis-in-the-nonobese-diabetic-mouse-model-of-sj%C3%A3-gren-syndrome
#12
Jennifer Y Barr, Xiaofang Wang, Portia A Kreiger, Scott M Lieberman
Immune cell-mediated destruction of salivary glands is a hallmark feature of Sjögren syndrome. Similar to the female predominance in humans, female nonobese diabetic (NOD) mice develop spontaneous salivary gland autoimmunity. However, in both humans and mice it is unclear what factors contribute to the initial immune infiltration of the salivary glands. Here, we used an adoptive transfer model of Sjögren syndrome to determine if female mice harbor a sex-specific defect in salivary gland-protective regulatory T (Treg) cells...
May 11, 2018: Immunology
https://www.readbyqxmd.com/read/29749438/oct4-suppresses-ir%C3%A2-induced-premature-senescence-in-breast-cancer-cells-through-stat3-and-nf%C3%A2-%C3%AE%C2%BAb-mediated-il%C3%A2-24-production
#13
Jeong-Yub Kim, Jeong-Chul Kim, Ji-Yun Lee, Myung-Jin Park
Breast cancer stem cells (BCSCs) are a small subpopulation of breast cancer cells that have been proposed to be a primary cause of failure of therapies, including ionizing radiation (IR). Their embryonic stem-like signature is associated with poor clinical outcome. In the present study, the function of octamer-binding transcription factor 4 (Oct4), an embryonic stem cell factor, in the resistance of BCSCs to IR was investigated. Mammosphere cells exhibited increased expression of stemness-associated genes, including Oct4 and sex‑determining region Y‑box 2 (Sox2), and were more resistant to IR compared with serum-cultured monolayer cells...
May 2, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29748283/the-histone-demethylase-kdm6b-regulates-temperature-dependent-sex-determination-in-a-turtle-species
#14
Chutian Ge, Jian Ye, Ceri Weber, Wei Sun, Haiyan Zhang, Yingjie Zhou, Cheng Cai, Guoying Qian, Blanche Capel
Temperature-dependent sex determination is a notable model of phenotypic plasticity. In many reptiles, including the red-eared slider turtle Trachemys scripta elegans ( T. scripta ), the individual's sex is determined by the ambient temperature during egg incubation. In this study, we show that the histone H3 lysine 27 (H3K27) demethylase KDM6B exhibits temperature-dependent sexually dimorphic expression in early T. scripta embryos before the gonad is distinct. Knockdown of Kdm6b at 26°C (a temperature at which all offspring develop into males) triggers male-to-female sex reversal in >80% of surviving embryos...
May 11, 2018: Science
https://www.readbyqxmd.com/read/29748122/the-tipping-point-for-931-elective-shoulder-arthroplasties
#15
Jeremy S Somerson, Jason E Hsu, Moni B Neradilek, Frederick A Matsen
BACKGROUND: A patient with arthritis usually experiences the progression of symptoms over time. At some stage, the patient may decide that the symptoms have reached a level of severity that leads him or her to elect to proceed with joint replacement; we refer to this degree of symptom severity as the "tipping point." Our goal was to study the factors that influenced the tipping point for patients undergoing elective shoulder arthroplasty. METHODS: We analyzed the characteristics of 931 patients undergoing shoulder arthroplasty to determine the factors affecting the tipping point as characterized by the patients' comfort and function at the time they determined their symptoms had progressed to the point when this elective surgery was merited...
May 7, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29742503/hsa_circ_0001275-a-potential-novel-diagnostic-biomarker-for-postmenopausal-osteoporosis
#16
Kewei Zhao, Qing Zhao, Zhaodi Guo, Zhixiang Chen, Yanwei Hu, Jing Su, Lian Chen, Zhiliang He, Xiuping Cai, Minyuan Chen, Lei Zheng, Wen Wang, Qian Wang
BACKGROUND/AIMS: Circular RNAs (circRNAs) serve as potential diagnostic biomarkers. In this study, we aimed to identify a potential biomarker from peripheral blood mononuclear cells (PBMCs) of patients with postmenopausal osteoporosis (PMOP). METHODS: CircRNA expression in PBMCs from three pairs of samples from PMOP patients and controls was initially detected by circRNA microarray. The changes in selected circRNAs in PBMCs from 28 PMOP patients and 21 age- and sex-matched controls were confirmed using quantitative reverse transcription polymerase chain reaction (qRT-PCR)...
May 5, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29735715/znrf3-functions-in-mammalian-sex-determination-by-inhibiting-canonical-wnt-signaling
#17
Abigail Harris, Pam Siggers, Silvia Corrochano, Nick Warr, Danielle Sagar, Daniel T Grimes, Makoto Suzuki, Rebecca D Burdine, Feng Cong, Bon-Kyoung Koo, Hans Clevers, Isabelle Stévant, Serge Nef, Sara Wells, Raja Brauner, Bochra Ben Rhouma, Neïla Belguith, Caroline Eozenou, Joelle Bignon-Topalovic, Anu Bashamboo, Ken McElreavey, Andy Greenfield
Mammalian sex determination is controlled by the antagonistic interactions of two genetic pathways: The SRY-SOX9-FGF9 network promotes testis determination partly by opposing proovarian pathways, while RSPO1/WNT-β-catenin/FOXL2 signals control ovary development by inhibiting SRY-SOX9-FGF9. The molecular basis of this mutual antagonism is unclear. Here we show that ZNRF3, a WNT signaling antagonist and direct target of RSPO1-mediated inhibition, is required for sex determination in mice. XY mice lacking ZNRF3 exhibit complete or partial gonadal sex reversal, or related defects...
May 7, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29731884/expression-of-microrna-638-and-sex-determining-region-y-box-2-in-hepatocellular-carcinoma-association-between-clinicopathological-features-and-prognosis
#18
Weikang Ye, Jieke Li, Guan Fang, Xiupeng Cai, Yan Zhang, Chaojun Zhou, Lei Chen, Wenjun Yang
The aim of the present study was to determine the expression profile of microRNA 638 (miR-638) and sex-determining region Y-box 2 (SOX2) in hepatocellular carcinoma (HCC), and to investigate their association with clinicopathological features and survival. Reverse transcription-quantitative polymerase chain reaction analysis was used to investigate miR-638 and SOX2 expression in 78 patients with HCC. Western blot and immunohistochemical analyses were performed in order to determine SOX2 protein expression in HCC samples...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29729225/diagnostic-utility-of-glycosyltransferase-mrna-expression-in-gastric-cancer
#19
Showkat Ahmad Bhat, Manzoor Ur Rahman Mir, Sabhiya Majid, Tehseen Hassan, Muneeb U Rehman, Sonallah Kuchy
OBJECTIVE/BACKGROUND: Posttranslational modification of proteins, including glycosylation, is known to differ between normal and tumor cells. Altered glycosyltransferase levels have been observed in tumor tissues and their role in tumor metastasis and invasion has been implicated. In this study the role of altered glycosyltransferase messenger RNA (mRNA) levels in serum of gastric cancer patients as early markers of gastric cancer was evaluated. METHODS: In this case control study the expression profile of ppGalNAc-T6, GlcNAcT-V, ST3Gal I, ST3 Gal IV, and ST6GalNAc-I in normal healthy control and gastric cancer patients was compared...
April 27, 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/29725413/expression-levels-of-the-runt-related-transcription-factor-1-and-3-genes-in-the-development-of-acute-myeloid-leukemia
#20
Adrian Krygier, Dagmara Szmajda, Marta Żebrowska, Agnieszka Jeleń, Ewa Balcerczak
The aim of the present study was to evaluate the mRNA expression level of the runt-related transcription factor 1 ( RUNX1 ) and runt-related transcription factor 3 ( RUNX3 ) genes in patients with acute myeloid leukemia (AML). The etiology of AML is not yet fully known, but certain genetic factors may contribute to its manifestation. The RUNX1 and RUNX3 genes have been demonstrated to serve a role in the transcription process. The group investigated in the present study included 43 patients diagnosed with AML, and the relative RUNX1 and RUNX3 expression levels were determined using reverse transcription-quantitative polymerase chain reaction...
May 2018: Oncology Letters
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