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Lawrence Yannuzzi

Ingrid Kreissig, Lawrence Yannuzzi, D Jackson Coleman, Stanley Chang
No abstract text is available yet for this article.
March 7, 2018: Acta Ophthalmologica
Lauren A Dalvin, Richard F Spaide, Lawrence A Yannuzzi, K Bailey Freund, Jose S Pulido
PURPOSE: To describe two cases of retinal detachment with hydration folds and discuss the possible cause of these outer retinal abnormalities. METHODS: The medical and imaging records of two patients with retinal detachment and hydration folds were examined. PATIENTS: A 43-year-old myopic woman who developed a retinal detachment secondary to a macular hole and a 35-year-old man referred with a rhegmatogenous retinal detachment masquerading as an exudative detachment were each found to have retinal hydration folds...
February 21, 2018: Retinal Cases & Brief Reports
Ingrid Kreissig, Lawrence Yannuzzi, D Jackson Coleman, Stanley Chang
No abstract text is available yet for this article.
January 27, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Kunal K Dansingani, Orly Gal-Or, Srinivas R Sadda, Lawrence A Yannuzzi, K Bailey Freund
The term aneurysmal type 1 neovascularization is derived from terminology, which is established in the literature but has fallen out of use. We believe that aneurysmal type 1 neovascularization accurately describes the lesions which define the entity known as polypoidal choroidal vasculopathy (PCV). Over the last three decades, the clinical spectrum of PCV has expanded to recognize the occurrence of the aneurysmal (polypoidal) lesions in different contexts, resulting in a complex and unwieldy taxonomy based sometimes on circumstantial findings rather than mechanistic considerations...
November 25, 2017: Clinical & Experimental Ophthalmology
(no author information available yet)
No abstract text is available yet for this article.
December 1, 2017: JAMA Ophthalmology
Riccardo Sacconi, K Bailey Freund, Lawrence A Yannuzzi, Rosa Dolz-Marco, Eric Souied, Vittorio Capuano, Oudy Semoun, Nopasak Phasukkijwatana, David Sarraf, Adriano Carnevali, Lea Querques, Francesco Bandello, Giuseppe Querques
PURPOSE: To expand our understanding of the uncommon entity, referred to as perifoveal exudative vascular anomalous complex (PEVAC) by describing multimodal imaging findings, including optical coherence tomography angiography (OCT-A). DESIGN: Retrospective cohort study. METHODS: Patients diagnosed with PEVAC were identified at 4 retina referral centers worldwide and underwent complete ophthalmologic examination including structural OCT, OCT-A, fluorescein angiography (FA), and indocyanine green angiography (ICGA)...
December 2017: American Journal of Ophthalmology
Katherine Boudreault, Kaspar Schuerch, Jin Zhao, Winston Lee, Thiago Cabral, Lawrence A Yannuzzi, Stephen H Tsang, Janet R Sparrow
Importance: Acute zonal occult outer retinopathy (AZOOR) remains a challenging diagnosis. Early recognition of the disease depends on advances in imaging modalities that can improve phenotyping and contribute to the understanding of the underlying pathogenesis. Objectives: To expand the range of approaches available to assist in the identification of AZOOR by multimodal imaging and to analyze the fundus lesions by quantifying short-wavelength fundus autofluorescence (quantitative fundus autofluorescence [qAF]) and spectral-domain optical coherence tomography...
October 26, 2017: JAMA Ophthalmology
Meleha Ahmad, Rosa Dolz-Marco, Yale L Fisher, Lawrence A Yannuzzi, Wenlan Zhang, Miguel Materin, Glenn J Jaffe
No abstract text is available yet for this article.
October 5, 2017: Retina
Chandrakumar Balaratnasingam, Svetlana Cherepanoff, Rosa Dolz-Marco, Murray Killingsworth, Fred K Chen, Randev Mendis, Sarah Mrejen, Lay Khoon Too, Orly Gal-Or, Christine A Curcio, K Bailey Freund, Lawrence A Yannuzzi
PURPOSE: To define the range and life cycles of cuticular drusen phenotypes using multimodal imaging and to review the histologic characteristics of cuticular drusen. DESIGN: Retrospective, observational cohort study and experimental laboratory study. PARTICIPANTS: Two hundred forty eyes of 120 clinic patients with a cuticular drusen phenotype and 4 human donor eyes with cuticular drusen (n = 2), soft drusen (n = 1), and hard drusen (n = 1)...
September 27, 2017: Ophthalmology
Irene Barbazetto, Kunal K Dansingani, Rosa Dolz-Marco, Alfonso Giovannini, F C Piccolino, Anita Agarwal, Luiz H Lima, Raul N Vianna, Lawrence A Yannuzzi
PURPOSE: To describe clinical findings in patients with acute exudative polymorphous vitelliform maculopathy (AEPVM). DESIGN: Retrospective, observational, multicenter case series review. PARTICIPANTS: Consecutive patients diagnosed with idiopathic AEPVM. METHODS: Review of clinical charts, multimodal imaging, electrophysiologic findings, and genetic findings in previously unpublished patients and review of the literature...
January 2018: Ophthalmology
Jasmine H Francis, Larissa A Habib, David H Abramson, Lawrence A Yannuzzi, Murk Heinemann, Mrinal M Gounder, Rachel N Grisham, Michael A Postow, Alexander N Shoushtari, Ping Chi, Neil H Segal, Rona Yaeger, Alan L Ho, Paul B Chapman, Federica Catalanotti
PURPOSE: To investigate the clinical and morphologic characteristics of serous retinal disturbances in patients taking mitogen-activated protein kinase kinase (MEK) inhibitors. PARTICIPANTS: A total of 313 fluid foci in 50 eyes of 25 patients receiving MEK inhibitors for treatment of their metastatic cancer, who had evidence of serous retinal detachments confirmed by optical coherence tomography (OCT). DESIGN: Single-center, retrospective cohort study...
December 2017: Ophthalmology
Quraish Ghadiali, Larissa K Ghadiali, Lawrence A Yannuzzi
PURPOSE: We describe a healthy 37-year-old man with Bartonella henselae (B. henselae) neuroretinitis with concurrent central retinal vein occlusion and ischemic optic neuropathy resulting in optic atrophy and choroidal ischemia. METHODS: Case report. RESULTS: A 37-year-old man presented with unilateral decreased vision and a fundus examination consistent with neuroretinitis. Further imaging review supported a concurrent diagnosis of central retinal vein occlusion...
July 11, 2017: Retinal Cases & Brief Reports
Ali Tavallali, Lawrence A Yannuzzi
No abstract text is available yet for this article.
April 2017: Journal of Ophthalmic & Vision Research
Richard F Spaide, Rosa D Marco, Lawrence A Yannuzzi
PURPOSE: To examine the alterations in retinal vascular morphology over an extended follow-up in eyes with macular telangiectasis Type 2 (MacTel2). METHODS: Eyes with high-quality digital photographs were evaluated. The geometric distortion in baseline images required to emulate the follow-up images was determined and vectors were made that represented the direction and magnitude of changes, to create a warp field. Optical coherence tomography and optical coherence tomography angiography evaluation of the retina was performed...
May 10, 2017: Retina
Anna C S Tan, Polina Astroz, Kunal K Dansingani, Jason S Slakter, Lawrence A Yannuzzi, Christine A Curcio, K Bailey Freund
Purpose: Histologic details of progression routes to geographic atrophy (GA) in AMD are becoming available through optical coherence tomography (OCT). We studied the origins and evolution of an OCT signature called plateau in eyes with GA and suggested a histologic correlate. Methods: Serial eye-tracked OCT scans and multimodal imaging were acquired from eight eyes of seven patients with GA and plateau signatures over a mean follow-up of 7.7 years (range, 3.7-11...
April 1, 2017: Investigative Ophthalmology & Visual Science
Orly Gal-Or, Paul T Finger, Yale L Fisher, Lawrence A Yannuzzi, K Bailey Freund
PURPOSE: To describe a patient with a presumed retinal pigment epithelium (RPE) tumor originating from unilateral RPE dysgenesis. METHODS: Case report. RESULTS: A 30-year-old woman with an unremarkable medical and ocular history was referred for an evaluation of progressive central metamorphopsia in her left eye. Visual acuity was 20/20 in her right eye and 20/25 in her left eye. Funduscopic examination of the left eye revealed an elevated mass within an area of unilateral RPE dysgenesis showing hyperpigmentation and hypopigmentation with scalloped margins...
March 22, 2017: Retinal Cases & Brief Reports
Thomas S Scerri, Anna Quaglieri, Carolyn Cai, Jana Zernant, Nori Matsunami, Lisa Baird, Lea Scheppke, Roberto Bonelli, Lawrence A Yannuzzi, Martin Friedlander, Catherine A Egan, Marcus Fruttiger, Mark Leppert, Rando Allikmets, Melanie Bahlo
Idiopathic juxtafoveal retinal telangiectasis type 2 (macular telangiectasia type 2; MacTel) is a rare neurovascular degenerative retinal disease. To identify genetic susceptibility loci for MacTel, we performed a genome-wide association study (GWAS) with 476 cases and 1,733 controls of European ancestry. Genome-wide significant associations (P < 5 × 10(-8)) were identified at three independent loci (rs73171800 at 5q14.3, P = 7.74 × 10(-17); rs715 at 2q34, P = 9.97 × 10(-14); rs477992 at 1p12, P = 2.60 × 10(-12)) and then replicated (P < 0...
April 2017: Nature Genetics
Anna C S Tan, Suzanne Yzer, Neal Atebara, Brian P Marr, Robert M Verdijk, Virgil A S H Dalm, K Bailey Freund, Lawrence Yannuzzi, Tom Missotten
PURPOSE: To report intraocular manifestations of Erdheim-Chester Disease (ECD) with multimodal imaging. DESIGN: A retrospective observational case series. METHODS: This was a multicenter case series of 3 patients with confirmed tissue diagnosis of ECD that showed intraocular manifestations and were imaged at baseline and follow-up visits. RESULTS: Intraocular manifestations are rarely observed in association with ECD...
April 2017: American Journal of Ophthalmology
Chandrakumar Balaratnasingam, Jeffrey D Messinger, Kenneth R Sloan, Lawrence A Yannuzzi, K Bailey Freund, Christine A Curcio
PURPOSE: Drusenoid pigment epithelium detachment (DPED) is a known precursor to geographic atrophy in age-related macular degeneration (AMD). We sought histologic correlates for spectral-domain (SD) optical coherence tomography (OCT) signatures in DPED and determined the frequency and origin of these OCT signatures in a clinical cohort of DPED eyes. DESIGN: Laboratory imaging and histologic comparison, and retrospective, observational cohort study. PARTICIPANTS: Four donor eyes with histopathologic diagnosis of AMD (2 with nonneovascular DPED and 2 with neovascular pigment epithelium detachment [PED]) and 49 eyes of 33 clinic patients with nonneovascular DPED more than 2 mm in diameter...
May 2017: Ophthalmology
Kevin C Chen, Marcela Marsiglia, Rosa Dolz-Marco, Sarwar Zahid, Sarah Mrejen, Jose S Pulido, Salomon Y Cohen, Benjamin Freilich, Lawrence A Yannuzzi, K Bailey Freund
PURPOSE: To describe atypical cases of multiple evanescent white dot syndrome (MEWDS) associated with foveal exudation, increased choroidal thickness, and secondary Type 2 (subretinal) neovascularization. METHODS: Four cases of atypical MEWDS were studied at a retina referral center. Patients underwent evaluation with multimodal retinal imaging, including fluorescein angiography, indocyanine green angiography, spectral-domain and enhanced depth imaging optical coherence tomography (OCT)...
November 2017: Retina
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