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Lawrence Yannuzzi

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https://www.readbyqxmd.com/read/28333854/presumed-retinal-pigment-epithelium-tumor-originating-from-unilateral-retinal-pigment-epithelium-dysgenesis
#1
Orly Gal-Or, Paul T Finger, Yale L Fisher, Lawrence A Yannuzzi, K Bailey Freund
PURPOSE: To describe a patient with a presumed retinal pigment epithelium (RPE) tumor originating from unilateral RPE dysgenesis. METHODS: Case report. RESULTS: A 30-year-old woman with an unremarkable medical and ocular history was referred for an evaluation of progressive central metamorphopsia in her left eye. Visual acuity was 20/20 in her right eye and 20/25 in her left eye. Funduscopic examination of the left eye revealed an elevated mass within an area of unilateral RPE dysgenesis showing hyperpigmentation and hypopigmentation with scalloped margins...
March 22, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28250457/genome-wide-analyses-identify-common-variants-associated-with-macular-telangiectasia-type-2
#2
Thomas S Scerri, Anna Quaglieri, Carolyn Cai, Jana Zernant, Nori Matsunami, Lisa Baird, Lea Scheppke, Roberto Bonelli, Lawrence A Yannuzzi, Martin Friedlander, Catherine A Egan, Marcus Fruttiger, Mark Leppert, Rando Allikmets, Melanie Bahlo
Idiopathic juxtafoveal retinal telangiectasis type 2 (macular telangiectasia type 2; MacTel) is a rare neurovascular degenerative retinal disease. To identify genetic susceptibility loci for MacTel, we performed a genome-wide association study (GWAS) with 476 cases and 1,733 controls of European ancestry. Genome-wide significant associations (P < 5 × 10(-8)) were identified at three independent loci (rs73171800 at 5q14.3, P = 7.74 × 10(-17); rs715 at 2q34, P = 9.97 × 10(-14); rs477992 at 1p12, P = 2.60 × 10(-12)) and then replicated (P < 0...
February 27, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28153505/three-cases-of-erdheim-chester-disease-with-intraocular-manifestations-imaging-and-histopathology-findings-of-a-rare-entity
#3
Anna C S Tan, Suzanne Yzer, Neal Atebara, Brian P Marr, Robert M Verdijk, Virgil A S H Dalm, K Bailey Freund, Lawrence Yannuzzi, Tom Missotten
PURPOSE: To report intraocular manifestations of ECD with multimodal imaging. DESIGN: A retrospective observational case series. METHODS: This was a multi-center case series of three patients with confirmed tissue diagnosis of ECD that showed intraocular manifestations and were imaged at baseline and follow-up visits. RESULTS: Intraocular manifestations are rarely observed in association with Erdheim-Chester disease (ECD)...
January 30, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28153442/histologic-and-optical-coherence-tomographic-correlates-in-drusenoid-pigment-epithelium-detachment-in-age-related-macular-degeneration
#4
Chandrakumar Balaratnasingam, Jeffrey D Messinger, Kenneth R Sloan, Lawrence A Yannuzzi, K Bailey Freund, Christine A Curcio
PURPOSE: Drusenoid pigment epithelium detachment (DPED) is a known precursor to geographic atrophy in age-related macular degeneration (AMD). We sought histologic correlates for spectral-domain (SD) optical coherence tomography (OCT) signatures in DPED and determined the frequency and origin of these OCT signatures in a clinical cohort of DPED eyes. DESIGN: Laboratory imaging and histologic comparison, and retrospective, observational cohort study. PARTICIPANTS: Four donor eyes with histopathologic diagnosis of AMD (2 with nonneovascular DPED and 2 with neovascular pigment epithelium detachment [PED]) and 49 eyes of 33 clinic patients with nonneovascular DPED more than 2 mm in diameter...
January 30, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28098736/foveal-exudate-and-choroidal-neovascularization-in-atypical-cases-of-multiple-evanescent-white-dot-syndrome
#5
Kevin C Chen, Marcela Marsiglia, Rosa Dolz-Marco, Sarwar Zahid, Sarah Mrejen, Jose S Pulido, Salomon Y Cohen, Benjamin Freilich, Lawrence A Yannuzzi, K Bailey Freund
PURPOSE: To describe atypical cases of multiple evanescent white dot syndrome (MEWDS) associated with foveal exudation, increased choroidal thickness, and secondary Type 2 (subretinal) neovascularization. METHODS: Four cases of atypical MEWDS were studied at a retina referral center. Patients underwent evaluation with multimodal retinal imaging, including fluorescein angiography, indocyanine green angiography, spectral-domain and enhanced depth imaging optical coherence tomography (OCT)...
January 16, 2017: Retina
https://www.readbyqxmd.com/read/28005717/40th-meeting-of-the-atlantic-coast-retina-club-macula-2016
#6
Yale L Fisher, Lawrence A Yannuzzi
No abstract text is available yet for this article.
January 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27994812/idiopathic-multifocal-choroiditis
#7
REVIEW
Ali Tavallali, Lawrence A Yannuzzi
Idiopathic multifocal choroiditis (MFC) and/or punctate inner choroidopathy (PIC) describe a chronic progressive bilateral inflammatory chorioretinopathy that predominantly affect healthy myopic white women with no known associated systemic or ocular diseases. The principal sites of involvement are the retinal pigment epithelium (RPE) and outer retinal spaces; the choroid is not affected during the active phase of the disease. Idiopathic MFC with atrophy is a recently described variant. Although there is no generally accepted standard treatment, anti-inflammatory and anti-VEGF (vascular endothelial growth factor) agents are necessary in the acute stage to control the inflammation and choroidal neovascularization (CNV)...
October 2016: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/27902539/cystoid-macular-edema-and-cystoid-macular-degeneration-as-a-result-of-multiple-pathogenic-factors-in-the-setting-of-central-serous-chorioretinopathy
#8
Polina Astroz, Chandrakumar Balaratnasingam, Lawrence A Yannuzzi
PURPOSE: To report the pathogenic factors that account for cystoid macular edema and cystoid macular degeneration in chronic central serous chorioretinopathy (CSC). METHODS: The clinical course and multimodal imaging findings, including fundus color photography, fundus autofluorescence, spectral-domain optical coherence tomography, and fluorescein angiography, of one eye with cystoid macular edema due to chronic CSC was documented. RESULTS: A 44-year old woman with a history of chronic CSC presented with progressive visual decline in the right eye...
January 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27880741/optical-coherence-tomography-angiography-of-chorioretinal-lesions-due-to-idiopathic-multifocal-choroiditis
#9
Sarwar Zahid, Kevin C Chen, Jesse J Jung, Chandrakumar Balaratnasingam, Quraish Ghadiali, John Sorenson, Soraya Rofagha, K Bailey Freund, Lawrence A Yannuzzi
PURPOSE: To evaluate the spectrum of macular chorioretinal lesions occurring in idiopathic multifocal choroiditis using optical coherence tomography angiography (OCTA) to evaluate those showing neovascular flow. METHODS: This was a descriptive, retrospective study of 18 eyes of 14 patients with multifocal choroiditis. Macular lesions were characterized as subretinal pigment epithelium, subretinal, or mixed and evaluated during active and presumed inactive states of multifocal choroiditis...
October 31, 2016: Retina
https://www.readbyqxmd.com/read/27760262/associations-between-retinal-pigment-epithelium-and-drusen-volume-changes-during-the-lifecycle-of-large-drusenoid-pigment-epithelial-detachments
#10
Chandrakumar Balaratnasingam, Lawrence A Yannuzzi, Christine A Curcio, William H Morgan, Giuseppe Querques, Vittorio Capuano, Eric Souied, Jesse Jung, K Bailey Freund
Purpose: Drusenoid pigment epithelial detachments (PEDs) are a defined path to atrophy in age-related macular degeneration (AMD). We analyzed the relationships between retinal pigment epithelium (RPE) and drusen volume changes during the PED lifecycle, using spectral-domain optical coherence tomography (SD-OCT). Methods: Twenty-one cases of drusenoid PED tracked using SD-OCT through periods of growth and collapse were evaluated. Volumetric calculations and piece-wise linear regression analysis were used to determine the breakpoint between growth and collapse...
October 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27749698/volume-rendered-angiographic-and-structural-optical-coherence-tomography-angiography-of-macular-telangiectasia-type-2
#11
Richard F Spaide, Mihoko Suzuki, Lawrence A Yannuzzi, Alexandre Matet, Francine Behar-Cohen
PURPOSE: To evaluate multimodal imaging including volume-rendered angiographic and structural optical coherence tomography of macular telangiectasia Type 2 (MacTel2) for right-angle vein complexes, macular cavitations, and signs of deeper retinal vascular invasion. METHODS: Retrospective review of imaging performed in a community-based retinal referral center. The eyes were scanned using optical coherence tomography using split-spectrum amplitude-decorrelation techniques to derive flow information...
September 30, 2016: Retina
https://www.readbyqxmd.com/read/27749497/type-3-neovascularization-imaged-with-cross-sectional-and-en-face-optical-coherence-tomography-angiography
#12
Anna C S Tan, Kunal K Dansingani, Lawrence A Yannuzzi, David Sarraf, K Bailey Freund
PURPOSE: To study the cross-sectional and en face optical coherence tomography angiography (OCTA) findings in Type 3 neovascularization (NV). METHODS: Optical coherence tomography angiography imaging of 27 eyes of 23 patients with Type 3 NV was analyzed with 9 eyes having consecutive follow-up OCTA studies. RESULTS: Type 3 NV appeared as a linear high-flow structure on cross-sectional OCTA corresponding to a high-flow tuft of vessels seen on en face OCTA...
February 2017: Retina
https://www.readbyqxmd.com/read/27711004/unusual-case-of-stellate-nonhereditary-idiopathic-foveomacular-retinoschisis
#13
Rosa Dolz-Marco, Kenneth Kato, K Bailey Freund, Lawrence A Yannuzzi
PURPOSE: To report a case of unilateral stellate nonhereditary idiopathic foveomacular retinoschisis (SNIFR) in a young male showing structural changes induced by a Valsalva maneuver. METHODS: Case report of a 26-year-old oboist with SNIFR, including multimodal imaging. Eye-tracked spectral-domain optical coherence tomography (SD-OCT) was used to compare the retinal architecture at rest and during a Valsalva maneuver. RESULTS: Spectral-domain optical coherence tomography showed macular and peripapillary retinoschisis with no signs of pathologic myopia, optic pit, or vitreoretinal traction...
January 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27640006/clinical-characteristics-choroidal-neovascularization-and-predictors-of-visual-outcomes-in-acquired-vitelliform-lesions
#14
Chandrakumar Balaratnasingam, Quan V Hoang, Maiko Inoue, Christine A Curcio, Rosa Dolz-Marco, Nicolas A Yannuzzi, Elona Dhrami-Gavazi, Lawrence A Yannuzzi, K Bailey Freund
PURPOSE: To quantify the temporal properties of the acquired vitelliform lesion (AVL) lifecycle, define the clinical characteristics of choroidal neovascularization (NV) in this setting and determine the predictors of long-term visual outcomes. DESIGN: Retrospective cohort study METHODS: Clinical and imaging data from 199 eyes of 124 consecutive patients with AVLs associated with age-related macular degeneration (AMD) and adult-onset foveomacular vitelliform dystrophy (AOFVD) were analyzed...
September 14, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27637783/a-perspective-on-the-nature-and-frequency-of-pigment-epithelial-detachments
#15
Anna C S Tan, Daniel Simhaee, Chandrakumar Balaratnasingam, Kunal K Dansingani, Lawrence A Yannuzzi
PURPOSE: To describe and compare the clinical and imaging characteristics of pigment epithelial detachments (PEDs) in age-related macular degeneration (AMD), polypoidal choroidal vasculopathy (PCV) and central serous chorioretinopathy (CSC) as seen in a clinical setting of a tertiary retinal practice. DESIGN: A perspective supported by clinical and imaging characteristics of a consecutive, cohort of patients with strictly defined PEDs. RESULTS: 174 eyes of 113 patients with PEDs were studied with comprehensive clinical retinal examination and multi-modal imaging; PEDs were differentiated into non-vascularized and vascularized forms with 3 main underlying etiologies: AMD (76%), PCV (9%) and CSC (3%)...
September 13, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27523615/visual-acuity-is-correlated-with-the-area-of-the-foveal-avascular-zone-in-diabetic-retinopathy-and-retinal-vein-occlusion
#16
Chandrakumar Balaratnasingam, Maiko Inoue, Seungjun Ahn, Jesse McCann, Elona Dhrami-Gavazi, Lawrence A Yannuzzi, K Bailey Freund
PURPOSE: To determine if the area of the foveal avascular zone (FAZ) is correlated with visual acuity (VA) in diabetic retinopathy (DR) and retinal vein occlusion (RVO). DESIGN: Cross-sectional study. PARTICIPANTS: Ninety-five eyes of 66 subjects with DR (65 eyes), branch retinal vein occlusion (19 eyes), and central retinal vein occlusion (11 eyes). METHODS: Structural optical coherence tomography (OCT; Spectralis, Heidelberg Engineering) and OCT angiography (OCTA; Avanti, Optovue RTVue XR) data from a single visit were analyzed...
November 2016: Ophthalmology
https://www.readbyqxmd.com/read/27506487/risk-alleles-associated-with-neovascularization-in-a-pachychoroid-phenotype
#17
Kunal K Dansingani, Lorah T Perlee, Sara Hamon, May Lee, Vinnie P Shah, Richard F Spaide, John Sorenson, James M Klancnik, Lawrence A Yannuzzi, Irene A Barbazetto, Michael J Cooney, Michael Engelbert, Christine Chen, Alex W Hewitt, K Bailey Freund
No abstract text is available yet for this article.
August 6, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27504697/full-thickness-macular-hole-combined-with-pigment-epithelial-detachment-using-multimodal-imaging
#18
Maiko Inoue, Anna Tan, Jason S Slakter, Stanley Chang, Kazuaki Kadonosono, Lawrence A Yannuzzi
PURPOSE: To describe two patients who showed full-thickness macular holes (FTMH) combined with pigment epithelial detachments (PED) and had contrasting outcomes to treatment. METHODS: A retrospective report of two cases. RESULTS: Case 1 was treated with intravitreal antivascular endothelial growth factor and photodynamic therapy, and the PED flattened. Subsequently, a vitrectomy was performed and the FTMH closed. Her visual acuity improved from 20/200 to 20/25...
August 8, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27472512/purtscher-retinopathy-as-a-manifestation-of-hemophagocytic-lymphohistiocytosis
#19
Dov B Sebrow, Elona Dhrami-Gavazi, Jason D Horowitz, Lawrence A Yannuzzi
PURPOSE: The authors describe a woman diagnosed with hemophagocytic lymphohistiocytosis and found to have retinal examination findings consistent with Purtscher retinopathy. METHODS: A 52-year-old woman underwent multimodal imaging, including color fundus photography and spectral-domain optical coherence tomography, to confirm the diagnosis. RESULTS: The ophthalmic examination and imaging confirmed the findings of Purtscher retinopathy with significant inner retinal thickening on spectral-domain optical coherence tomography...
July 28, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27349411/subretinal-hyperreflective-material-imaged-with-optical-coherence-tomography-angiography
#20
Kunal K Dansingani, Anna C S Tan, Fatimah Gilani, Nopasak Phasukkijwatana, Eduardo Novais, Lea Querques, Nadia K Waheed, Jay S Duker, Giuseppe Querques, Lawrence A Yannuzzi, David Sarraf, K Bailey Freund
PURPOSE: The range of subretinal hyperreflective material (SHRM) seen in macular disease includes type 2 macular neovascularization, fibrosis, exudation, vitelliform material, and hemorrhage. The prognostic significance of SHRM has been evaluated retrospectively in clinical trials, but discriminating SHRM subtypes traditionally requires multiple imaging modalities. The purpose of this study is to describe optical coherence tomography angiography (OCTA) flow characteristics and artifacts that might help to distinguish SHRM subtypes...
September 2016: American Journal of Ophthalmology
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