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Michael Engelbert

Florian W Kiefer, Yvonne Winhofer, Donato Iacovazzo, Marta Korbonits, Stefan Wolfsberger, Engelbert Knosp, Franz Trautinger, Romana Höftberger, Michael Krebs, Anton Luger, Alois Gessl
CONTEXT: Carney complex (CNC) is an autosomal dominant condition caused, in most cases, by an inactivating mutation of the PRKAR1A gene, which encodes for the type 1 alpha regulatory subunit of protein kinase A. CNC is characterized by the occurrence of endocrine overactivity, myxomas and typical skin manifestations. Cushing syndrome due to primary pigmented nodular adrenocortical disease (PPNAD) is the most frequent endocrine disease observed in CNC. CASE DESCRIPTION: Here we describe the first case of a patient with CNC and adrenocorticotropic hormone (ACTH)-dependent Cushing disease due to a pituitary corticotroph adenoma...
May 18, 2017: European Journal of Endocrinology
Quraish Ghadiali, Sarwar Zahid, Rosa Dolz-Marco, Anna Tan, Michael Engelbert
Purpose. To compare the stages of vitreous degeneration in patients with vitreomacular traction (VMT) and macular holes (MH). Methods. A retrospective study was performed analyzing stages of vitreous degeneration of eyes with VMT or MH using swept-source optical coherence tomography (SS-OCT) and spectral-domain optical coherence tomography (SD-OCT). An analogous review was performed on a control group of eyes with contralateral posterior vitreous detachments. Thirty-four eyes with VMT/MH and 39 control eyes were reviewed...
2017: Journal of Ophthalmology
Chandrakumar Balaratnasingam, Sara Vaz-Pereira, Michael Engelbert
No abstract text is available yet for this article.
January 2017: Retina
Jonathan I Huz, Krishna Mukkamala, Ivelisse Rodriguez Pagan, David Ritterband, Mahendra Shah, Ronald C Gentile, Michael Engelbert
PURPOSE: To compare the antibiotic susceptibilities and visual acuity (VA) outcomes in endophthalmitis caused by methicillin-resistant (MRSA) versus methicillin-sensitive S. aureus (MSSA). METHODS: The records of 34 cases of S. aureus endophthalmitis at The New York Eye and Ear Infirmary from Jan 1997 to June 2011 were reviewed. Antibiotic susceptibility profiles over time and VA at presentation and at 3, 6, and ≥12 months were recorded. S. aureus isolates were grouped based on oxacillin resistance...
October 19, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
Sara Vaz-Pereira, Kunal K Dansingani, Kevin C Chen, Michael J Cooney, James M Klancnik, Michael Engelbert
PURPOSE: To describe anatomical relationships of retinal neovascular complexes (NVCs) and the posterior vitreous in proliferative diabetic retinopathy using spectral domain optical coherence tomography. METHODS: Cross-sectional study. Neovascular complexes were imaged using spectral domain optical coherence tomography in 51 eyes of 37 patients. The relationship of NVCs to the posterior vitreous cortex and posterior vitreous spaces, such as the premacular bursa, prevascular vitreous fissures, and perimacular cisterns, was analyzed...
September 30, 2016: Retina
Jesse T McCann, Michael Engelbert
PURPOSE: To report a giant retinal pigment epithelium rip in a patient with a bullous retinal and choroidal detachment. METHODS: Case report with widefield imaging, fundus autofluorescence, and optical coherence tomography of the retina. RESULTS: This 62-year-old patient had a history of advanced glaucoma, trabeculectomy, blebitis, and endophthalmitis. He had cataract surgery 6 weeks before presentation. He was found to have a large bullous retinal and choroidal detachment with a large retinal pigment epithelium tear at the limit of the choroidal detachment...
August 9, 2016: Retinal Cases & Brief Reports
Kunal K Dansingani, Lorah T Perlee, Sara Hamon, May Lee, Vinnie P Shah, Richard F Spaide, John Sorenson, James M Klancnik, Lawrence A Yannuzzi, Irene A Barbazetto, Michael J Cooney, Michael Engelbert, Christine Chen, Alex W Hewitt, K Bailey Freund
No abstract text is available yet for this article.
August 6, 2016: Ophthalmology
Michael Oldenburg, Andrey Turshatov, Dmitry Busko, Stephanie Wollgarten, Michael Adams, Nicolò Baroni, Alexander Welle, Engelbert Redel, Christof Wöll, Bryce S Richards, Ian A Howard
Triplet transfer across a surface-anchored metal-organic-framework heterojunction is demonstrated by the observation of triplet-triplet annihilation photon -upconversion in a sensitizer-emitter heterostructure. Upconversion thresholds under 1 mW cm(-2) are achieved. In the broader context, the double-electron-exchange mechanism of triplet transfer indicates that the heterojunction quality is sufficient for electrons to move between layers in this solution-processed crystalline heterostructure.
October 2016: Advanced Materials
David Stegner, Michael Popp, Viola Lorenz, Jacqueline K Wax, J Engelbert Gessner, Bernhard Nieswandt
The activating platelet collagen receptor glycoprotein VI (GPVI) is a promising antithrombotic target because of its central role in arterial thrombosis and its minor relevance for normal hemostasis. The receptor can be specifically targeted by antibodies and irreversibly downregulated in circulating platelets in vivo, resulting in long-term antithrombotic protection in mice. This GPVI immunodepletion predominantly occurs through ectodomain shedding, which is accompanied by a transient drop in peripheral platelet counts...
August 11, 2016: Blood
Andrea Grosso, Grazia Pertile, Giorgio Marchini, Giuseppe Scarpa, Piero Ceruti, Guido Prigione, Mario R Romano, Fabrizio Bert, Renata Gili, Claudio Panico, Roberta Siliquini, Michael Engelbert
PURPOSE: To survey the surgical routines with regards to prophylactic strategies in a sample of Italian hospitals and compare these with European Society for Cataract and Refractive Surgery (ESCRS) guidelines. METHODS: Six private and 18 public hospitals were included in this clinical-based retrospective study. The overall volume of cataract operations in the 24 centers in 2013 was 43,553. Main outcome measure was incidence of endophthalmitis per 1,000. An incidence of less than 0...
August 4, 2016: European Journal of Ophthalmology
Kristin S Suhr, Michael F Chiang, John T Flynn, Michael Engelbert
PURPOSE: Hemophagocytic syndrome (HS) is a rare disease with a spectrum of ocular findings. The authors report a unique funduscopic presentation of HS in a neonate and a discussion of diagnosis, typical features, management, and outcome. METHODS: Single case report with retrospective analysis of the published literature of patients with HS and ocular findings from 1950 to present using the key terms hemophagocytic, lymphohistiocytosis, ocular, and ophthalmic. Literature search from 1950 to the present was performed through PubMed/MEDLINE and the Cochrane database...
2016: Retinal Cases & Brief Reports
Chandrakumar Balaratnasingam, Bora Chae, Meredith H Remmer, Erasmo Gomez, Mihoko Suzuki, Michael Engelbert, Richard F Spaide
PURPOSE: Macular pigments are preferentially concentrated in the central fovea, an area devoid of vasculature. We hypothesized that there may be a link between the macular pigment profile and the size and structural characteristics of the foveal avascular zone (FAZ). METHODS: Two-wavelength autofluorescence method was used to quantify macular pigment optical density (MPOD) and the radius at half peak of MPOD, which was defined as the retinal eccentricity where the MPOD value was 50% of the peak value...
December 2015: Investigative Ophthalmology & Visual Science
Kevin C Chen, Jesse J Jung, Michael Engelbert
BACKGROUND/PURPOSE: To report the swept-source optical coherence tomography (SS-OCT) findings in a case of acute toxoplasmosis chorioretinitis. METHODS: A 35-year-old male presented with acute blurry vision and floaters in his left eye. Ophthalmic examination, color photographs, spectral-domain OCT (SD-OCT), enhanced depth imaging OCT (EDI-OCT), SS-OCT and wide-field fluorescein angiography images were obtained to diagnose and follow the subsequent changes of toxoplasmosis chorioretinitis over a 2-month period...
2016: Retinal Cases & Brief Reports
Kevin C Chen, Jesse J Jung, Michael Engelbert
No abstract text is available yet for this article.
March 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
K Bailey Freund, Michael Engelbert, Howard F Fine
No abstract text is available yet for this article.
May 2015: Ophthalmic Surgery, Lasers & Imaging Retina
Kevin C Chen, Jesse J Jung, Michael Engelbert
No abstract text is available yet for this article.
November 2015: Graefe's Archive for Clinical and Experimental Ophthalmology
Claudine E Pang, Karen B Schaal, Michael Engelbert
PURPOSE: To demonstrate the presence of prevascular vitreous fissures (PVF) and posterior vitreous cisterns in vivo and correlate with the degree of vitreous degeneration (VD). METHODS: This was a cross-sectional study using Topcon Deep Range Imaging OCT-1 Atlantis 3D swept source optical coherence tomography for acquiring scans of posterior vitreous covering an 18 × 18-mm area in 104 eyes of 52 healthy volunteers without posterior vitreous detachment. RESULTS: We observed that increasing age was associated with higher VD grades (P < 0...
September 2015: Retina
Christine Y Chen, Michael Engelbert, K Bailey Freund, Carol L Shields, Gaetano Barile
No abstract text is available yet for this article.
December 2014: JAMA Ophthalmology
Yvonne Winhofer, Peter Wolf, Martin Krššák, Stefan Wolfsberger, Andrea Tura, Giovanni Pacini, Alois Gessl, Wolfgang Raber, Ivica Just Kukurova, Alexandra Kautzky-Willer, Engelbert Knosp, Siegfried Trattnig, Michael Krebs, Anton Luger
CONTEXT: PATIENTS with acromegaly frequently display disturbances of glucose and lipid metabolism, which might contribute to their increased cardiovascular risk. Because insulin resistance and increased lipolysis have been linked to ectopic lipid deposition, altered lipid accumulation in the liver and the myocardium might contribute to metabolic and cardiac complications in these patients. OBJECTIVE: The aim of this study was to investigate myocardial (MYCL) and hepatic lipid content (HCL), insulin sensitivity, and cardiac function in active acromegaly and after control of GH excess through transsphenoidal surgery...
November 2014: Journal of Clinical Endocrinology and Metabolism
Claudine E Pang, K Bailey Freund, Michael Engelbert
No abstract text is available yet for this article.
September 2014: JAMA Ophthalmology
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