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tDCS and weight

Xiao-Su Hu, Clayton A Fisher, Stephanie M Munz, Rebecca L Toback, Thiago D Nascimento, Emily L Bellile, Laura Rozek, Avraham Eisbruch, Francis P Worden, Theodora E Danciu, Alexandre F DaSilva
Patients with head and neck cancer often experience a significant decrease in their quality of life during chemoradiotherapy (CRT) due to treatment-related pain, which is frequently classified as severe. Transcranial direct current stimulation (tDCS) is a method of non-invasive brain stimulation that has been frequently used in experimental and clinical pain studies. In this pilot study, we investigated the clinical impact and central mechanisms of twenty primary motor cortex (M1) stimulation sessions with tDCS during 7 weeks of CRT for head and neck cancer...
2016: Frontiers in Human Neuroscience
Étienne Ojardias, Oscar Azeo, Diana Rimaud, Pascal Giraux
OBJECTIVE: Transcortical direct current stimulation (tDCS) is an emerging technique in the rehabilitation of hemiplegic patients after stroke, and has been mainly evaluated for the upper limb. The feasibility and tolerance of the use of repeated stimulations on the lower limb motor cortex require a clinical evaluation. OBSERVATIONS: A 72-year-old patient, who suffered from a first ischemic stroke in the left middle cerebral artery area, on July 2015, was admitted, 6 months post-stroke, to the PRM outpatient clinic of the university hospital of Saint-Étienne, for a motor training program combined with iterative tDCS stimulations...
September 2016: Annals of Physical and Rehabilitation Medicine
M Ljubisavljevic, K Maxood, J Bjekic, J Oommen, N Nagelkerke
BACKGROUND: The dorsolateral prefrontal cortex (DLPFC) plays an important role in the regulation of food intake. Several previous studies demonstrated that a single session of transcranial direct current stimulation (tDCS) of the DLPFC reduces food craving and caloric intake. OBJECTIVES: We hypothesized that repeated tDCS of the right DLPFC cortex may exert long-term changes in food craving in young, healthy adults and that these changes may differ between normal and overweight subjects...
July 15, 2016: Brain Stimulation
Ilkka Laakso, Satoshi Tanaka, Marko Mikkonen, Soichiro Koyama, Norihiro Sadato, Akimasa Hirata
The electric field produced in the brain is the main physical agent of transcranial direct current stimulation (tDCS). Inter-subject variations in the electric fields may help to explain the variability in the effects of tDCS. Here, we use multiple-subject analysis to study the strength and variability of the group-level electric fields in the standard brain space. Personalized anatomically-accurate models of 62 subjects were constructed from T1- and T2-weighted MRI. The finite-element method was used to computationally estimate the individual electric fields, which were registered to the standard space using surface based registration...
August 15, 2016: NeuroImage
Wen-Hsuan Hou, Tzu-Ya Wang, Jiunn-Horng Kang
OBJECTIVES: The effects of non-invasive brain stimulation (NBS), including repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (TDCS), in treating FM remain inconclusive. The aim of this study was to investigate present evidence of using NBS as an add-on treatment in treating FM. METHODS: We conducted a database search of the Medline, Embase, PsycINFO and Cochrane Library electronic databases, from inception to July 2015, to analyse randomized controlled trials of NBS in treating FM...
August 2016: Rheumatology
I C Macedo, C de Oliveira, R Vercelino, A Souza, G Laste, L F Medeiros, V L Scarabelot, E A Nunes, J Kuo, F Fregni, W Caumo, I L S Torres
It has been suggested that food craving-an intense desire to consume a specific food (particularly foods high in sugar and fat)-can lead to obesity. This behavior has also been associated with abuse of other substances, such as drugs. Both drugs and food cause dependence by acting on brain circuitry involved in reward, motivation, and decision-making processes. The dorsolateral prefrontal cortex (DLPFC) can be activated following evocation and is implicated in alterations in food behavior and craving. Transcranial direct current stimulation (tDCS), a noninvasive brain stimulation technique capable of modulates brain activity significantly, has emerged as a promising treatment to inhibit craving...
August 1, 2016: Appetite
Karen Blackmon, Emma Ben-Avi, Xiuyuan Wang, Heath R Pardoe, Adriana Di Martino, Eric Halgren, Orrin Devinsky, Thomas Thesen, Ruben Kuzniecky
Malformations of cortical development are found at higher rates in autism spectrum disorder (ASD) than in healthy controls on postmortem neuropathological evaluation but are more variably observed on visual review of in-vivo MRI brain scans. This may be due to the visually elusive nature of many malformations on MRI. Here, we utilize a quantitative approach to determine whether a volumetric measure of heterotopic gray matter in the white matter is elevated in people with ASD, relative to typically developing controls (TDC)...
2016: NeuroImage: Clinical
Yasser Ghanbari, Luke Bloy, Birkan Tunc, Varsha Shankar, Timothy P L Roberts, J Christopher Edgar, Robert T Schultz, Ragini Verma
Brain networks based on resting state connectivity as well as inter-regional anatomical pathways obtained using diffusion imaging have provided insight into pathology and development. Such work has underscored the need for methods that can extract sub-networks that can accurately capture the connectivity patterns of the underlying population while simultaneously describing the variation of sub-networks at the subject level. We have designed a multi-layer graph clustering method that extracts clusters of nodes, called 'network hubs', which display higher levels of connectivity within the cluster than to the rest of the brain...
December 1, 2015: Medical Image Analysis
Gabriela L Bravo, Albert B Poje, Iago Perissinotti, Bianca F Marcondes, Mauricio F Villamar, Ann M Manzardo, Laura Luque, Jean F LePage, Diane Stafford, Felipe Fregni, Merlin G Butler
Prader-Willi syndrome (PWS) is a neurodevelopmental genetic disorder characterized by intellectual disabilities and insatiable appetite with compulsive eating leading to severe obesity with detrimental health consequences. Transcranial direct current stimulation (tDCS) has been shown to modulate decision-making and cue-induced food craving in healthy adults. We conducted a pilot double blind, sham-controlled, multicenter study of tDCS modulation of food drive and craving in 10 adult PWS participants, 11 adult obese (OB) and 11 adult healthy-weight control (HWC) subjects...
March 2016: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
Marci E Gluck, Miguel Alonso-Alonso, Paolo Piaggi, Christopher M Weise, Reiner Jumpertz-von Schwartzenberg, Martin Reinhardt, Eric M Wassermann, Colleen A Venti, Susanne B Votruba, Jonathan Krakoff
OBJECTIVE: Obesity is associated with decreased activity in the prefrontal cortex. Transcranial direct current stimulation (tDCS) modifies cortical excitability and may facilitate improved control of eating. The energy intake (EI) and body weight in subjects who received cathodal versus sham (study 1) and subsequent anodal versus sham (study 2) tDCS aimed at the left dorsolateral prefrontal cortex (LDLPFC) were measured. METHODS: Nine (3m, 6f) healthy volunteers with obesity (94 ± 15 kg [M ± SD]; 42 ± 8 y) were admitted as inpatients for 9 days to participate in a double-blind, randomized, placebo-controlled crossover experiment...
November 2015: Obesity
Pratik Y Chhatbar, Viswanathan Ramakrishnan, Steven Kautz, Mark S George, Robert J Adams, Wuwei Feng
BACKGROUND AND PURPOSE: Transcranial direct current stimulation (tDCS) has shown mixed results in post-stroke motor recovery, possibly because of tDCS dose differences. The purpose of this meta-analysis was to explore whether the outcome has a dose-response relationship with various dose-related parameters. METHODS: The literature was searched for double-blind, randomized, sham-controlled clinical trials investigating the role of tDCS (≥5 sessions) in post-stroke motor recovery as measured by the Fugl-Meyer Upper Extremity (FM-UE) scale...
January 2016: Brain Stimulation
Camila Cosmo, Cândida Ferreira, José Garcia Vivas Miranda, Raphael Silva do Rosário, Abrahão Fontes Baptista, Pedro Montoya, Eduardo Pondé de Sena
BACKGROUND: Transcranial direct current stimulation (tDCS) is known to modulate spontaneous neural network excitability. The cognitive improvement observed in previous trials raises the potential of this technique as a possible therapeutic tool for use in attention-deficit/hyperactivity disorder (ADHD) population. However, to explore the potential of this technique as a treatment approach, the functional parameters of brain connectivity and the extent of its effects need to be more fully investigated...
2015: Frontiers in Psychiatry
Abbas Z Kouzani, Shapour Jaberzadeh, Maryam Zoghi, Clara Usma, Mahboubeh Parastarfeizabadi
Research is being conducted on the use of transcranial direct current stimulation (tDCS) for therapeutic effects, and also on the mechanisms through which such therapeutic effects are mediated. A bottleneck in the progress of the research has been the large size of the existing tDCS systems which prevents subjects from performing their daily activities. To help research into the principles, mechanisms, and benefits of tDCS, reduction of size and weight, improvement in simplicity and user friendliness, portability, and programmability of tDCS systems are vital...
January 2016: IEEE Transactions on Neural Systems and Rehabilitation Engineering
Oh In Kwon, Saurav Z K Sajib, Igor Sersa, Tong In Oh, Woo Chul Jeong, Hyung Joong Kim, Eung Je Woo
OBJECTIVE: Transcranial direct current stimulation (tDCS) is a neuromodulatory technique for neuropsychiatric diseases and neurological disorders. In the tDCS treatment, dc current is injected into the head through a pair of electrodes attached on the scalp over a target region. A current density imaging method is needed to quantitatively visualize the internal current density distribution during the tDCS treatment. METHODS: We developed a novel current density image reconstruction algorithm using 1) a subject specific segmented 3-D head model, 2) diffusion tensor data, and 3) magnetic flux density data induced by the tDCS current...
January 2016: IEEE Transactions on Bio-medical Engineering
D Val-Laillet, E Aarts, B Weber, M Ferrari, V Quaresima, L E Stoeckel, M Alonso-Alonso, M Audette, C H Malbert, E Stice
Functional, molecular and genetic neuroimaging has highlighted the existence of brain anomalies and neural vulnerability factors related to obesity and eating disorders such as binge eating or anorexia nervosa. In particular, decreased basal metabolism in the prefrontal cortex and striatum as well as dopaminergic alterations have been described in obese subjects, in parallel with increased activation of reward brain areas in response to palatable food cues. Elevated reward region responsivity may trigger food craving and predict future weight gain...
2015: NeuroImage: Clinical
Yan Ren, Yuehua Cui, Xinrong Li, Binhong Wang, Long Na, Junyan Shi, Liang Wang, Lixia Qiu, Kerang Zhang, Guifen Liu, Yong Xu
Long non-coding RNAs (lncRNAs) are emerging as important regulators of gene expression and disease processes especially in neuropsychiatric disorders. To explore the potential regulatory roles of lncRNAs in schizophrenia, we performed an integrated co-expression network analysis on lncRNA and mRNA microarray profiles generated from the peripheral blood samples in 19 drug-naïve first-episode early-onset schizophrenia (EOS) patients and 18 demographically matched typically developing controls (TDCs). Using weighted gene co-expression network analysis (WGCNA), we showed that the lncRNAs were organized into co-expressed modules, and two lncRNA modules were associated with EOS...
December 3, 2015: Progress in Neuro-psychopharmacology & Biological Psychiatry
Hang Ye, Shu Chen, Daqiang Huang, Siqi Wang, Jun Luo
When making choices under uncertainty, people usually consider both the risks and benefits of each option. Previous studies have found that weighing of risks and benefits during decision-making involves a complex neural network that includes the dorsolateral prefrontal cortex (DLPFC), but the causal effect of this network on risk decision-making has remained unclear. This experiment was based on a risk-measurement table designed to provide a direct measure of risk preference, with a weighted value of the choices (denoted as weighted risk aversion, WRA) as an index of the participant's degree of risk aversion...
June 1, 2015: Behavioural Brain Research
Kamila Jauch-Chara, Ferdinand Binkofski, Michaela Loebig, Kathrin Reetz, Gianna Jahn, Uwe H Melchert, Ulrich Schweiger, Kerstin M Oltmanns
Brain energy consumption induced by electrical stimulation increases systemic glucose tolerance in normal-weight men. In obesity, fundamental reductions in brain energy levels, gray matter density, and cortical metabolism, as well as chronically impaired glucose tolerance, suggest that disturbed neuroenergetic regulation may be involved in the development of overweight and obesity. Here, we induced neuronal excitation by anodal transcranial direct current stimulation versus sham, examined cerebral energy consumption with (31)P magnetic resonance spectroscopy, and determined systemic glucose uptake by euglycemic-hyperinsulinemic glucose clamp in 15 normal-weight and 15 obese participants...
June 2015: Diabetes
Giulio Ruffini, Michael D Fox, Oscar Ripolles, Pedro Cavaleiro Miranda, Alvaro Pascual-Leone
Recently, multifocal transcranial current stimulation (tCS) devices using several relatively small electrodes have been used to achieve more focal stimulation of specific cortical targets. However, it is becoming increasingly recognized that many behavioral manifestations of neurological and psychiatric disease are not solely the result of abnormality in one isolated brain region but represent alterations in brain networks. In this paper we describe a method for optimizing the configuration of multifocal tCS for stimulation of brain networks, represented by spatially extended cortical targets...
April 1, 2014: NeuroImage
J Yang, R Li, Y Ren, Y Yang, R Xie, H Fan
Tolerogenic dendritic cells (tDCs) potently induce and maintain tolerance based on their distinct characteristics compared with conventional DCs. Recent reports show that donor or host tDCs promote allograft survival in mice. In this study, the efficacy of third-party tDCs in the prevention of acute graft-versus-host disease (aGVHD) was evaluated. In vitro, tDCs derived from the bone marrow (BM) of D1 mice were induced by GM-CSF, IL-10 and TGF-β1. The phenotypes, expression of cytokines and suppression of tDCs were analysed...
December 2013: Scandinavian Journal of Immunology
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