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https://www.readbyqxmd.com/read/28545198/assessing-breast-cancer-awareness-in-thai-women-validation-of-the-breast-cancer-awareness-scale-b-cas
#1
Nitchamon Rakkapao, Supannee Promthet, Malcolm Anthony Moore, Solikhah Solikhah, Cameron Hurst
Background: Raising breast cancer awareness is a well-established first line strategy to reduce breast cancer mortality. A properly validated instrument is needed to gain a better understanding of breast cancer awareness. Objective: The objective of this study was to develop and validate an instrument to assess breast cancer awareness in Thai women. Methods: In this study, we develop and evaluate the validity of the Breast Cancer Awareness Scale (B-CAS). Construct validity was evaluated by using exploratory factor analysis and confirmatory factor analysis, and criterion validity was investigated using ROC curves to examine the associations between B-CAS subscales and breast self-examination...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28545155/rapid-diagnostic-tests-for-typhoid-and-paratyphoid-enteric-fever
#2
REVIEW
Lalith Wijedoru, Sue Mallett, Christopher M Parry
BACKGROUND: Differentiating both typhoid (Salmonella Typhi) and paratyphoid (Salmonella Paratyphi A) infection from other causes of fever in endemic areas is a diagnostic challenge. Although commercial point-of-care rapid diagnostic tests (RDTs) for enteric fever are available as alternatives to the current reference standard test of blood or bone marrow culture, or to the widely used Widal Test, their diagnostic accuracy is unclear. If accurate, they could potentially replace blood culture as the World Health Organization (WHO)-recommended main diagnostic test for enteric fever...
May 26, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28545094/economic-evaluation-of-policy-options-for-dialysis-in-end-stage-renal-disease-patients-under-the-universal-health-coverage-in-indonesia
#3
Afiatin, Levina Chandra Khoe, Erna Kristin, Lusiana Siti Masytoh, Eva Herlinawaty, Pitsaphun Werayingyong, Mardiati Nadjib, Sudigdo Sastroasmoro, Yot Teerawattananon
OBJECTIVES: This study aims to assess the value for money and budget impact of offering hemodialysis (HD) as a first-line treatment, or the HD-first policy, and the peritoneal dialysis (PD) first policy compared to a supportive care option in patients with end-stage renal disease (ESRD) in Indonesia. METHODS: A Markov model-based economic evaluation was performed using local and international data to quantify the potential costs and health-related outcomes in terms of life years (LYs) and quality-adjusted life years (QALYs)...
2017: PloS One
https://www.readbyqxmd.com/read/28545053/mortality-among-blood-donors-seropositive-and-seronegative-for-chagas-disease-1996-2000-in-s%C3%A3-o-paulo-brazil-a-death-certificate-linkage-study
#4
Ligia Capuani, Ana Luiza Bierrenbach, Airlane Pereira Alencar, Alfredo Mendrone, João Eduardo Ferreira, Brian Custer, Antonio Luiz P Ribeiro, Ester Cerdeira Sabino
BACKGROUND: Individuals in the indeterminate phase of Chagas disease are considered to have mortality rates similar to those of the overall population. This study compares mortality rates among blood donors seropositive for Chagas disease and negative controls in the city of São Paulo, Brazil. METHODOLOGY/PRINCIPAL FINDINGS: This is a retrospective cohort study of blood donors from 1996 to 2000: 2842 seropositive and 5684 seronegative for Chagas disease. Death status was ascertained by performing probabilistic record linkage (RL) with the Brazil national mortality information system (SIM)...
May 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28544626/countering-evidence-denial-and-the-promotion-of-pseudoscience-in-autism-spectrum-disorder
#5
Isabel M Smith, Noni E MacDonald
This commentary introduces a framework within which clinical and research experts in autism spectrum disorder (ASD) can address public instances of evidence denial and promotion of pseudoscience related to ASD. This is a generalized extension of work by a World Health Organization (WHO) group dedicated to reducing the influence of Vocal Vaccine Deniers through educating advocates in how to effectively defuse their arguments. The WHO guidelines were informed by conceptual work on the "denialism" phenomenon, and by studies in psychology, communication, vaccine science, and public health...
May 22, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28544484/neglected-issues-concerning-teaching-human-adrenal-steroidogenesis-in-popular-biochemistry-textbooks
#6
Zhiyong Han, Mark S Elliott
In the human body, the adrenal steroids collectively regulate a plethora of fundamental functions, including electrolyte and water balance, blood pressure, stress response, intermediary metabolism, inflammation, and immunity. Therefore, adrenal steroidogenesis is an important biochemistry topic for students to learn in order for them to understand health consequences caused by deficiencies of enzymes in the adrenal steroidogenic pathways. However, popular biochemistry textbooks contain insufficient information and may sometimes give students a misimpression about certain aspects of human adrenal steroidogenesis...
May 19, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28544448/using-pymol-to-explore-the-effects-of-ph-on-noncovalent-interactions-between-immunoglobulin-g-and-protein-a-a-guided-inquiry-biochemistry-activity
#7
Zahilyn D Roche Allred, Heeyoung Tai, Stacey Lowery Bretz, Richard C Page
Students' understandings of foundational concepts such as noncovalent interactions, pH and pKa are crucial for success in undergraduate biochemistry courses. We developed a guided-inquiry activity to aid students in making connections between noncovalent interactions and pH/pKa . Students explore these concepts by examining the primary and tertiary structures of immunoglobulin G (IgG) and Protein A. Students use PyMOL, an open source molecular visualization application, to (1) identify hydrogen bonds and salt bridges between and within the proteins at physiological pH and (2) apply their knowledge of pH/pKa to association rate constant data for these proteins at pH 4 and pH 11...
May 24, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28544437/autonomy-support-in-people-with-mild-to-borderline-intellectual-disability-testing-the-health-care-climate-questionnaire-intellectual-disability
#8
Noud Frielink, Carlo Schuengel, Petri J C M Embregts
BACKGROUND: Autonomy support in people with intellectual disability (ID) is an important yet understudied topic. Psychometrically sound instruments are lacking. This study tested the factor structure and reliability of an instrument for assessing the extent people with intellectual disability perceive their support staff as autonomy supportive. METHOD: In a single wave, 185 adults with mild-to-borderline intellectual disability filled in an adapted version of the Health Care Climate Questionnaire (i...
May 24, 2017: Journal of Applied Research in Intellectual Disabilities: JARID
https://www.readbyqxmd.com/read/28544163/the-impact-of-clinical-practice-on-the-outcome-of-central-venous-access-devices-in-children-with-haemophilia
#9
K Khair, S Ranta, A Thomas, K Lindvall
INTRODUCTION: Central venous access devices facilitate home treatment in boys with haemophilia. These are usually fully implanted lines, referred to as ports. Caregivers are taught to manage the port using sterile techniques and maintaining patency by flushing with saline or heparin solution. National and international guidelines for the home care of ports are lacking. AIM: To evaluate if infection or occlusion rates differ between home care regimens used for ports in children with haemophilia...
May 24, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/28544037/using-experience-based-co-design-for-the-development-of-physical-activity-provision-in-non-acute-rehabilitation-and-recovery-mental-health-care
#10
Evan Matthews, Mary Cowman, Suzanne Denieffe
Despite advances in recovery focused mental health care, people with severe mental illness (SMI) experience multiple physical comorbidity compounded by unhealthy lifestyle behaviours including low levels of physical activity (Vancampfort et al. 2017; Walker et al. 2015). Responding to this, international policy is moving to include physical activity as part of fundamental care for people with severe mental illness (Pratt et al. 2016; Richardson et al. 2005). Incorporation of physical activity into mental health service provision should adopt an approach that is in keeping with best practice, recovery orientated guidelines of mental health service provision, with particular consideration shown to incorporating service users as partners in care plan development and delivery (Department of Health, 2001; Department of Health and Children, 2006)...
May 19, 2017: Journal of Psychiatric and Mental Health Nursing
https://www.readbyqxmd.com/read/28543973/advancing-the-adverse-outcome-pathway-framework-an-international-horizon-scanning-approach
#11
Carlie A LaLone, Gerald T Ankley, Scott E Belanger, Michelle R Embry, Geoff Hodges, Dries Knapen, Sharon Munn, Edward J Perkins, Murray A Rudd, Daniel L Villeneuve, Maurice Whelan, Catherine Willett, Xiaowei Zhang, Markus Hecker
Our ability to conduct whole-organism toxicity tests to understand chemical safety has been outpaced by the synthesis of new chemicals for a wide variety of commercial applications. As a result, scientists and risk assessors are turning to mechanistically based studies to increase efficiencies in chemical risk assessment and making greater use of in vitro and in silico methods to evaluate potential environmental and human health hazards. In this context, the adverse outcome pathway (AOP) framework has gained traction in regulatory science because it offers an efficient and effective means for capturing available knowledge describing the linkage between mechanistic data and the apical toxicity end points required for regulatory assessments...
June 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28543954/health-professionals-personal-behaviours-hindering-health-promotion-a-study-of-nurses-who-smoke
#12
Agurtzane Mujika, María Arantzamendi, Olga Lopez-Dicastillo, Angus Forbes
AIM: To explore the views of current and ex-smoker nurses on their role in supporting patients to stop smoking. BACKGROUND: Long-term conditions are closely linked to harmful lifestyle behaviours, including smoking and overeating. Health professionals have an important role to play in promoting healthier lifestyles. It has been described that nurses' health behaviours may be a barrier to their health promotion practice. There is a need to gain further understanding on why nurses' health promotion activity is influenced by their own health behaviour...
May 24, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28543184/a-systematic-review-of-patient-reported-measures-associated-with-vestibular-dysfunction
#13
REVIEW
Vicky M Stewart, M Dilani Mendis, Nancy Low Choy
OBJECTIVES/HYPOTHESIS: Use of clinical questionnaires to assist in the screening of vestibular disorders in the acute hospital setting is needed. The objective is to detail the clinimetric properties and clinical utility of patient-reported questionnaires for quantifying dizziness/vertigo symptoms associated with vestibular dysfunction, and to determine validity and utility for screening dizziness/vertigo in the emergency department. DATA SOURCES: We performed a systematic review of PubMed, CINAHL, Embase, and Web of Science in May 2015...
May 23, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28543019/the-burden-of-chronic-spontaneous-urticaria-is-substantial-real-world-evidence-from-assure-csu
#14
Marcus Maurer, Mohamed Abuzakouk, Frédéric Bérard, Walter Canonica, Hanneke Oude Elberink, Ana Giménez-Arnau, Clive Grattan, Kelly Hollis, André Knulst, Jean-Philippe Lacour, Charles Lynde, Alexander Marsland, Doreen McBride, Alla Nakonechna, Javier Ortiz de Frutos, Christina Proctor, Gordon Sussman, Carolyn Sweeney, Haijun Tian, Karsten Weller, Daniel Wolin, Maria-Magdalena Balp
BACKGROUND: Chronic spontaneous urticaria (CSU) can be debilitating, difficult to treat, and frustrating for patients and physicians. Real-world evidence for the burden of CSU is limited. The objective of this study was to document disease duration, treatment history, and disease activity, as well as impact on health-related quality of life (HRQoL) and work among patients with inadequately controlled CSU, and to describe its humanistic, societal, and economic burden. METHODS: This international observational study assessed a cohort of 673 adult patients with CSU whose symptoms persisted for ≥12 months despite treatment...
May 19, 2017: Allergy
https://www.readbyqxmd.com/read/28542796/interleukin-2-as-an-adjunct-to-antiretroviral-therapy-for-hiv-positive-adults
#15
REVIEW
Jennifer Onwumeh, Charles I Okwundu, Tamara Kredo
BACKGROUND: Human immunodeficiency virus (HIV) continues to be a leading cause of morbidity and mortality, particularly in sub-Saharan Africa. Although antiretroviral drugs have helped to improve the quality of life and life expectancy of HIV-positive individuals, there is still a need to explore other interventions that will help to further reduce the disease burden. One potential strategy is the use of interleukin-2 (IL-2) in combination with antiretroviral therapy (ART). IL-2 is a cytokine that regulates the proliferation and differentiation of lymphocytes and may help to boost the immune system...
May 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28542615/taking-dietary-habits-into-account-a-computational-method-for-modeling-food-choices-that-goes-beyond-price
#16
Rahmatollah Beheshti, Jessica C Jones-Smith, Takeru Igusa
Computational models have gained popularity as a predictive tool for assessing proposed policy changes affecting dietary choice. Specifically, they have been used for modeling dietary changes in response to economic interventions, such as price and income changes. Herein, we present a novel addition to this type of model by incorporating habitual behaviors that drive individuals to maintain or conform to prior eating patterns. We examine our method in a simulated case study of food choice behaviors of low-income adults in the US...
2017: PloS One
https://www.readbyqxmd.com/read/28542226/german-validation-of-quality-of-life-after-brain-injury-qolibri-assessment-and-associated-factors
#17
Nicole von Steinbüchel, Ruben G L Real, Nadine Sasse, Lindsay Wilson, Christiane Otto, Ryan Mullins, Robert Behr, Wolfgang Deinsberger, Ramon Martinez-Olivera, Wolfgang Puschendorf, Werner Petereit, Veit Rohde, Holger Schmidt, Stephan Sehmisch, Klaus Michael Stürmer, Klaus von Wild, Henning Gibbons
The consequences of traumatic brain injury (TBI) for health-related quality of life (HRQoL) are still poorly understood, and no TBI-specific instrument has hitherto been available. This paper describes in detail the psychometrics and validity of the German version of an internationally developed, self-rated HRQoL tool after TBI-the QOLIBRI (Quality of Life after Brain Injury). Factors associated with HRQoL, such as the impact of cognitive status and awareness, are specifically reported. One-hundred seventy-two participants after TBI were recruited from the records of acute clinics, most of whom having a Glasgow Coma Scale (GCS) 24-hour worst score and a Glasgow Outcome Scale (GOSE) score...
2017: PloS One
https://www.readbyqxmd.com/read/28542009/interpretation-of-urinary-excretion-data-from-plutonium-wound-cases-treated-with-dtpa-application-of-different-models-and-approaches
#18
Deepesh Poudel, Luiz Bertelli, John A Klumpp, Tom L Waters
After a chelation treatment, assessment of intake and doses is the primary concern of an internal dosimetrist. Using the urinary excretion data from two actual wound cases encountered at Los Alamos National Laboratory (LANL), this paper discusses several methods that can be used to interpret intakes from the urinary data collected after one or multiple chelation treatments. One of the methods uses only the data assumed to be unaffected by chelation (data collected beyond 100 d after the last treatment). This method, used by many facilities for official dose records, was implemented by employing maximum likelihood analysis and Bayesian analysis methods...
July 2017: Health Physics
https://www.readbyqxmd.com/read/28541882/web-app-based-patient-education-in-psoriasis-a-randomized-controlled-trial
#19
Spencer D Hawkins, Steven Barilla, Steven R Feldman
PURPOSE: Patients report wanting more information about psoriasis and clear expectations from the onset of therapy. Dermatologists do not think patients receive or internalize adequate information. There isa need for further explanation of treatment regimens to increase knowledge, compliance, and patient satisfaction. Recent advancements in web technology have the potential to improve these psoriasis outcomes. METHODS: A web based application was created to educate psoriasis patients using video, graphics, and textual information...
April 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28541595/how-does-ivabradine-effect-erectile-dysfunction-in-patients-with-heart-failure
#20
Fatih Aydın, Serkan Bektur, Yasin Taşdelen, Yüksel Kıvrak, Ayşe Hüseyinoglu Aydın
BACKGROUND AND AIM: Erectile dysfunction (ED) is the inability or insufficiensy of penile erection that causes dissatisfaction during sexual intercourse. ED is seen in patients with heart failure (HF) ranging from %56-81 depending on the severity. Patients usually blame their cardiovascular medications for their ED. Ivabradine is used for antianginal effects and to improve exercise intolerance and decrease mortality in patients with HF. Most beta-blockers are known to cause ED but unlike beta-blockers the effect of ivabradine over ED has never been evaluated...
May 25, 2017: Kardiologia Polska
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