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https://www.readbyqxmd.com/read/29651656/using-lithium-in-children-and-adolescents-with-bipolar-disorder-efficacy-tolerability-and-practical-considerations
#1
REVIEW
B Grant, J A Salpekar
Lithium has been an intriguing treatment option in psychiatry for over a century. While seemingly just a simple elemental compound, it has powerful treatment effects for both depression and bipolar disorder. The evidence base for treatment of pediatric bipolar disorder is relatively small, but, in recent years, additional clinical trial data have enabled lithium to re-emerge as a valuable and, in many cases, preferred treatment. Pharmacologically, lithium is complex, with varied effects at both intracellular and extracellular levels...
April 12, 2018: Paediatric Drugs
https://www.readbyqxmd.com/read/29626337/network-neuroscience-a-framework-for-developing-biomarkers-in-psychiatry
#2
David M Lydon-Staley, Danielle S Bassett
Psychiatric disorders are disturbances of cognitive and behavioral processes mediated by the brain. Emerging evidence suggests that accurate biomarkers for psychiatric disorders might benefit from incorporating information regarding multiple brain regions and their interactions with one another, rather than considering local perturbations in brain structure and function alone. Recent advances in the field of applied mathematics generally - and network science specifically - provide a language to capture the complexity of interacting brain regions, and the application of this language to fundamental questions in neuroscience forms the emerging field of network neuroscience...
April 7, 2018: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/29625429/a-latent-variable-approach-to-differentiating-neural-mechanisms-of-irritability-and-anxiety-in-youth
#3
Katharina Kircanski, Lauren K White, Wan-Ling Tseng, Jillian Lee Wiggins, Heather R Frank, Stefanie Sequeira, Susan Zhang, Rany Abend, Kenneth E Towbin, Argyris Stringaris, Daniel S Pine, Ellen Leibenluft, Melissa A Brotman
Importance: Comorbidity is ubiquitous in psychiatry, but it is unclear how to differentiate neural mechanisms of co-occurring symptoms. Pediatric irritability and anxiety symptoms are prevalent and frequently co-occur. Threat orienting is pertinent to both phenotypes and is an ideal context in which to examine their unique and common neural mechanisms. Objectives: To decompose the unique and shared variances of pediatric irritability and anxiety symptoms and to determine neural correlates of these differentiated phenotypes during threat orienting...
April 6, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29606317/behavioral-disorders-the-blind-spot-of-neurology-and-psychiatry
#4
REVIEW
C Azuar, R Levy
Behavioral disorders occupy the crossroads between neurology and psychiatry, and emerging disorders, such as frontotemporal lobar degeneration of genetic origin and autoimmune encephalitis, can present with both neurological and psychiatric signs. Thus, the primary aim of this introductory article is to review frequently encountered behavioral clinical features, such as apathy and agitation, and their related syndromes, including frontal and anterior temporal syndromes. These behavioral states and their underlying etiologies are also here illustrated with clinical case reports...
March 29, 2018: Revue Neurologique
https://www.readbyqxmd.com/read/29604314/zebrafish-models-relevant-to-studying-central-opioid-and-endocannabinoid-systems
#5
REVIEW
Konstantin A Demin, Darya A Meshalkina, Elana V Kysil, Kristina A Antonova, Andrey D Volgin, Oleg A Yakovlev, Polina A Alekseeva, Maria M Firuleva, Anton M Lakstygal, Murilo S de Abreu, Leonardo J G Barcellos, Wandong Bao, Ashton J Friend, Tamara G Amstislavskaya, Denis B Rosemberg, Pavel E Musienko, Cai Song, Allan V Kalueff
The endocannabinoid and opioid systems are two interplaying neurotransmitter systems that modulate drug abuse, anxiety, pain, cognition, neurogenesis and immune activity. Although they are involved in such critical functions, our understanding of endocannabinoid and opioid physiology remains limited, necessitating further studies, novel models and new model organisms. Zebrafish (Danio rerio) is rapidly emerging as one of the most effective translational models in neuroscience and biological psychiatry. Due to their high physiological and genetic homology to humans, zebrafish may be effectively used to study the endocannabinoid and opioid systems...
March 28, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29596725/antagonists-in-the-medical-management-of-opioid-use-disorders-historical-and-existing-treatment-strategies
#6
REVIEW
Adam Bisaga, Paolo Mannelli, Maria A Sullivan, Suzanne K Vosburg, Peggy Compton, George E Woody, Thomas R Kosten
BACKGROUND AND OBJECTIVES: Opioid use disorder (OUD) is a chronic condition with potentially severe health and social consequences. Many who develop moderate to severe OUD will repeatedly seek treatment or interact with medical care via emergency department visits or hospitalizations. Thus, there is an urgent need to develop feasible and effective approaches to help persons with OUD achieve and maintain abstinence from opioids. Treatment that includes one of the three FDA-approved medications is an evidence-based strategy to manage OUD...
April 2018: American Journal on Addictions
https://www.readbyqxmd.com/read/29594942/the-endoplasmic-reticulum-stress-response-in-neuroprogressive-diseases-emerging-pathophysiological-role-and-translational-implications
#7
REVIEW
Gerwyn Morris, Basant K Puri, Ken Walder, Michael Berk, Brendon Stubbs, Michael Maes, André F Carvalho
The endoplasmic reticulum (ER) is the main cellular organelle involved in protein synthesis, assembly and secretion. Accumulating evidence shows that across several neurodegenerative and neuroprogressive diseases, ER stress ensues, which is accompanied by over-activation of the unfolded protein response (UPR). Although the UPR could initially serve adaptive purposes in conditions associated with higher cellular demands and after exposure to a range of pathophysiological insults, over time the UPR may become detrimental, thus contributing to neuroprogression...
March 29, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29593578/mental-disorder-the-need-for-an-accurate-definition
#8
Diogo Telles-Correia, Sérgio Saraiva, Jorge Gonçalves
There are several reasons why a definition for mental disorder is essential. Among these are not only reasons linked to psychiatry itself as a science (nosology, research) but also to ethical, legal, and financial issues. The first formal definition of mental disorder resulted from a deep conceptual analysis led by Robert Spitzer. It emerged to address several challenges that psychiatry faced at the time, namely to serve as the starting point for an atheoretical and evidence-based classification of mental disorders, to justify the removal of homosexuality from classifications, and to counter the arguments of antipsychiatry...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29582688/the-politics-and-practice-of-thomas-adeoye-lambo-towards-a-post-colonial-history-of-transcultural-psychiatry
#9
Matthew M Heaton
This article traces the career of Thomas Adeoye Lambo, the first European-trained psychiatrist of indigenous Nigerian (Yoruba) background and one of the key contributors to the international development of transcultural psychiatry from the 1950s to the 1980s. The focus on Lambo provides some political, cultural and geographical balance to the broader history of transcultural psychiatry by emphasizing the contributions to transcultural psychiatric knowledge that have emerged from a particular non-western context...
March 1, 2018: History of Psychiatry
https://www.readbyqxmd.com/read/29580705/-consultation-liaison-addiction-medicine-tools-and-specificities
#10
P Poloméni, G Cleirec, C Icard, A Ramos, B Rolland
Since the 1970s, the concept of "consultation/liaison (CL) psychiatry" has pertained to specialized mobile teams which meet inpatients hospitalized in non-psychiatric settings to offer them on-the-spot psychiatric assessment, treatment, and, if needed, adequate referral. Since the birth of CL psychiatry, a long set of theoretical books and articles has aimed at integrating CL psychiatry into the wider scope of psychosomatic medicine. In the year 2000, a circular issued by the Health Ministry defined the organization of "CL addiction services" in France...
March 23, 2018: L'Encéphale
https://www.readbyqxmd.com/read/29580702/-methods-to-improve-suicidal-adolescents-compliance-to-care-after-emergency-discharge-a-literature-review
#11
J Lachal, S Grandclerc, M Spodenkiewicz, M R Moro
OBJECTIVES: Suicidal adolescents admitted in an Emergency Department (ED) present a high risk of suicidal reattempts. Poor observance of follow-up in this particular group imped the efficacity of the treatment. We propose to summarize the international literature on ED interventions promoting suicidal adolescents' adherence to care. METHOD: We carried out a comprehensive review of papers listed in PubMed, PsycInfo, and CINHAL databases using keywords about adolescence, suicide, and ED...
March 23, 2018: L'Encéphale
https://www.readbyqxmd.com/read/29569022/professionals-views-on-the-development-process-of-a-structural-collaboration-between-child-and-adolescent-psychiatry-and-child-welfare-an-exploration-through-the-lens-of-the-life-cycle-model
#12
Helena Van den Steene, Dirk van West, Griet Peeraer, Inge Glazemakers
This study, as a part of a participatory action research project, reports the development process of an innovative collaboration between child and adolescent psychiatry and child welfare, for adolescent girls with multiple and complex needs. The findings emerge from a qualitative descriptive analysis of four focus groups with 30 professionals closely involved in this project, and describe the evolution of the collaborative efforts and outcomes through time. Participants describe large investments and negative consequences of rapid organizational change in the beginning of the collaboration project, while benefits of the intensive collaboration only appeared later...
March 23, 2018: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29564546/sports-psychiatry-mental-health-and-mental-disorders-in-athletes-and-exercise-treatment-of-mental-disorders
#13
REVIEW
Andreas Ströhle
Sports psychiatry has developed for the past 3 decades as an emerging field within psychiatry and sports medicine. An International society has been established in 1994 and also national interest groups were implemented, mostly within the national organizations for psychiatry, some also containing the topic of exercise treatment of mental disorders. Where are we now 30 years later? We systematically but also selectively review the medical literature on exercise, sport, psychiatry, mental health and mental disorders and related topics...
March 21, 2018: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/29560835/how-argentina-is-training-their-mental-health-residents-to-face-its-silver-tsunami
#14
Sergio A Strejilevich, Florencia Vallejos, Julian Bustin
In low- and middle-income countries, there is an increase in the percentage of aging population similar to or greater than that of high-income countries (World Population Ageing 1950-2050, UN, 2001). The emerging health and economical challenges due to these demographic changes will have to be addressed by their health systems. In this context, an adequate training of available human resources in geriatric psychiatry/psychogeriatrics (GP/PG) should be an essential step to meet those challenges.
March 21, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/29557314/-hans-heinze-and-the-research-programme-of-the-german-association-of-child-psychiatry-and-therapeutic-education-1942-1945
#15
Klaus Schepker, Thomas Beddies
Hans Heinze and the Research Programme of the German Association of Child Psychiatry and Therapeutic Education 1942-1945 Upon its foundation in 1940, Paul Schröder, full professor for psychiatry in Leipzig, was the first president of the German Society for Child Psychiatry and Therapeutic Education (DGKH). Following his death in 1941, his student Hans Heinze (Brandenburg/H.) succeeded him, prevailing over Werner Villinger (Breslau). The principal task of the DGKH was considered to be the exploration of the genetic origins of intellectual disabilities and behavioural disorders among children and adolescents...
September 2017: Praxis der Kinderpsychologie und Kinderpsychiatrie
https://www.readbyqxmd.com/read/29549821/improving-suicide-risk-assessment-in-the-emergency-department-through-physician-education-and-a-suicide-risk-assessment-prompt
#16
Taras R Reshetukha, Nazanin Alavi, Eric Prost, Ryan H Kirkpatrick, Saad Sajid, Charmy Patel, Dianne L Groll
OBJECTIVE: To determine the efficacy of two interventions on suicide risk assessment within emergency departments (EDs) on improving the documentation of suicide risk factors by emergency medicine and psychiatric physicians during suicide risk assessment. METHOD: An educational intervention on suicide was provided to all emergency medicine and psychiatry physicians and was followed by the placement of a suicide risk assessment prompt within local EDs. The medical charts of all ED patients presenting with suicidal ideation or behaviours were reviewed immediately and six months after the interventions and compared to pre-intervention...
March 2, 2018: General Hospital Psychiatry
https://www.readbyqxmd.com/read/29528720/patient-treatment-and-health-care-utilization-variables-associated-with-adherence-to-metabolic-monitoring-practices-in-children-and-adolescents-taking-second-generation-antipsychotics
#17
Mary Coughlin, Catherine Lindsay Goldie, Joan Tranmer, Sarosh Khalid-Khan, Deborah Tregunno
OBJECTIVE: Children and adolescents with a range of psychiatric disorders are increasingly being prescribed atypical or second-generation antipsychotics (SGAs). While SGAs are effective at treating conduct and behavioural symptoms, they infer significant cardiometabolic risk. This study aims to explore what patient, treatment, and health care utilization variables are associated with adherence to Canadian Alliance for Monitoring Effectiveness and Safety of Antipsychotics in Children (CAMESA) metabolic monitoring guidelines...
January 1, 2018: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/29528597/-transition-from-child-and-adolescent-to-adult-mental-health-care
#18
F Carbonez, M Al Husni Al Keilani, C Kornreich, V Delvenne
Adolescents and young adults are at particularly at-risk population in mental health. For a large majority of patients suffering from chronic psychiatric condition, the age of onset of psychiatric symptoms is less than 24 years, while the coverage in psychiatric care is the lowest between 16 and 24. Presenting a psychiatric pathology during childhood and adolescence constitutes an independent risk factor for the occurrence of adverse life events in adulthood. Furthermore, that population is at the edge between child and adolescent mental health services (CAMHS) and adult mental health services (AMHS)...
2018: Revue Médicale de Bruxelles
https://www.readbyqxmd.com/read/29528294/clinical-applications-of-stochastic-dynamic-models-of-the-brain-part-ii-a-review
#19
REVIEW
James A Roberts, Karl J Friston, Michael Breakspear
Brain activity derives from intrinsic dynamics (due to neurophysiology and anatomical connectivity) in concert with stochastic effects that arise from sensory fluctuations, brainstem discharges, and random microscopic states such as thermal noise. The dynamic evolution of systems composed of both dynamic and random fluctuations can be studied with stochastic dynamic models (SDMs). This article, Part II of a two-part series, reviews applications of SDMs to large-scale neural systems in health and disease. Stochastic models have already elucidated a number of pathophysiological phenomena, such as epilepsy and hypoxic ischemic encephalopathy, although their use in biological psychiatry remains rather nascent...
April 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29527056/the-role-of-work-in-psychiatry-historical-reflections
#20
REVIEW
Waltraud Ernst
Until recently, the role of patient work in the history of psychiatry has been a neglected dimension. Yet, in the psychiatric institutions that emerged across the world from the late eighteenth century onwards, work and work therapy were prominent features, culminating in the rise of a specialist profession affiliated to medicine - occupational therapy. This article explores the changing meanings of work within varied medical, social, and political contexts.
February 2018: Indian Journal of Psychiatry
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