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https://www.readbyqxmd.com/read/29786959/assessment-of-the-drug-interaction-potential-of-ertugliflozin-with-sitagliptin-metformin-glimepiride-or-simvastatin-in-healthy-subjects
#1
Vikas Kumar Dawra, David L Cutler, Susan Zhou, Rajesh Krishna, Haihong Shi, Yali Liang, Christine Alvey, Anne Hickman, Didier Saur, Steven G Terra, Vaishali Sahasrabudhe
Ertugliflozin, a sodium-glucose cotransporter 2 inhibitor for the treatment of adults with type 2 diabetes mellitus, is expected to be coadministered with sitagliptin, metformin, glimepiride, and/or simvastatin. Four separate open-label, randomized, single-dose, crossover studies were conducted in healthy adults to assess the potential pharmacokinetic interactions between ertugliflozin 15 mg and sitagliptin 100 mg (n = 12), metformin 1000 mg (n = 18), glimepiride 1 mg (n = 18), or simvastatin 40 mg (n = 18)...
May 22, 2018: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29785937/the-effect-of-enzyme-replacement-therapy-on-clinical-outcomes-in-paediatric-patients-with-fabry-disease-a-systematic-literature-review-by-a-european-panel-of-experts
#2
REVIEW
Marco Spada, Ralf Baron, Perry M Elliott, Bruno Falissard, Max J Hilz, Lorenzo Monserrat, Camilla Tøndel, Anna Tylki-Szymańska, Christoph Wanner, Dominique P Germain
BACKGROUND: Fabry disease is caused by a deficiency of the lysosomal enzyme α-galactosidase, resulting in progressive accumulation of globotriaosylceramide (GL-3). The disease can manifest early during childhood and adolescence. Enzyme replacement therapy (ERT) with recombinant human α-galactosidase is the first specific treatment for Fabry disease and has been available in Europe since 2001. This paper presents the findings of a systematic literature review of clinical outcomes with ERT in paediatric patients with Fabry disease...
April 26, 2018: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29785591/association-of-reduced-sclerostin-expression-with-collapse-process-in-patients-with-osteonecrosis-of-the-femoral-head
#3
Xiao-Jun Chen, Fan Yang, Zhen-Qiu Chen, Min-Cong He, Guo-Ju Hong, Jun-Yuan Huang, Ying-Chun Zhou, Yi-Xian Qin, Qiu-Shi Wei, Wei He
PURPOSE: Sclerostin is an osteocyte-derived protein that has a potent inhibitory effect on osteoblast activity. The osteocyte apoptosis induced by various causes of osteonecrosis of the femoral head (ONFH) plays a key role in the promotion of femoral head collapse. But the effect of altering sclerostin level on the collapse of ONFH has not been studied. Our aim was to assess the role of sclerostin level in the collapse of ONFH. METHODS: Between May 2016 and November 2016, 236 subjects were enrolled in the present study...
May 21, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29785229/the-circular-rna-hsa_circ_0001445-regulates-the-proliferation-and-migration-of-hepatocellular-carcinoma-and-may-serve-as-a-diagnostic-biomarker
#4
Xianwei Zhang, Hu Zhou, Wei Jing, Ping Luo, Shili Qiu, Xuefang Liu, Man Zhu, Chunzi Liang, Mingxia Yu, Jiancheng Tu
Circular RNAs (circRNA), a class of noncoding RNAs, have been found to be involved in various diseases. Here, the expression levels of the circRNA hsa_circ_0001445 in 73 pairs of hepatocellular carcinoma (HCC) and adjacent nontumor tissues were investigated by quantitative real-time polymerase chain reaction (qRT-PCR). Our data demonstrate that the hsa_circ_0001445 levels were significantly decreased in HCC tissues ( P < 0.001) and markedly associated with the number of tumor foci ( P = 0.014). Furthermore, in vitro approaches showed that overexpression of hsa_circ_0001445 promoted apoptosis and inhibited proliferation, migration, and invasion of HCC-derived cells, suggesting that hsa_circ_0001445 might be involved in the development of HCC...
2018: Disease Markers
https://www.readbyqxmd.com/read/29784943/thomson-scattering-in-inhomogeneous-plasmas-the-role-of-the-fluctuation-dissipation-theorem
#5
V V Belyi
A self-consistent kinetic theory of Thomson scattering of an electromagnetic field by a non-uniform plasma is derived. We draw the readers' attention to the inconsistency in recent results on the Thomson scattering in inhomogeneous plasma, which leads to violation of the Fluctuation-Dissipation Theorem. We show, that not only the imaginary part, but also the derivatives of the real part of the dielectric susceptibility determine the amplitude and the width of the Thomson scattering spectral lines. As a result of inhomogeneity, these properties become asymmetric with respect to inversion of the sign of the frequency...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29784761/slc15a2-and-slc15a4-mediate-the-transport-of-bacterially-derived-di-tripeptides-to-enhance-the-nucleotide-binding-oligomerization-domain-dependent-immune-response-in-mouse-bone-marrow-derived-macrophages
#6
Yongjun Hu, Feifeng Song, Huidi Jiang, Gabriel Nuñez, David E Smith
There is increasing evidence that proton-coupled oligopeptide transporters (POTs) can transport bacterially derived chemotactic peptides and therefore reside at the critical interface of innate immune responses and regulation. However, there is substantial contention regarding how these bacterial peptides access the cytosol to exert their effects and which POTs are involved in facilitating this process. Thus, the current study proposed to determine the (sub)cellular expression and functional activity of POTs in macrophages derived from mouse bone marrow and to evaluate the effect of specific POT deletion on the production of inflammatory cytokines in wild-type, Pept2 knockout and Pht1 knockout mice...
May 21, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29784322/peanut-flour-aggregation-with-polyphenolic-extracts-derived-from-peanut-skin-inhibits-ige-binding-capacity-and-attenuates-rbl-2h3-cells-degranulation-via-mapk-signaling-pathway
#7
Rishipal R Bansode, Nathalie J Plundrich, Priscilla D Randolph, Mary Ann Lila, Leonard L Williams
This study investigates the anti-allergic properties of peanut skin polyphenols (PSP)-enriched peanut (PN) protein aggregates. PSP was blended with PN flour at concentrations of 5, 10, 15, 30, and 40% (w/w). Rat basophil leukemia cells (RBL-2H3) were sensitized with either anti-DNP-IgE or PN-allergic plasma followed by co-exposure to unmodified PN flour (control) or PSP-PN protein aggregates and Ca2+ ionophore, ionomycin. Immunoblotting and staining were performed to measure the IgE binding capacity of PSP-PN aggregates...
October 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29784012/treatment-of-experimental-colitis-by-endometrial-regenerative-cells-through-regulation-of-b-lymphocytes-in-mice
#8
Xiaoxi Xu, Yong Wang, Baoren Zhang, Xu Lan, Shanzheng Lu, Peng Sun, Xiang Li, Ganggang Shi, Yiming Zhao, Hongqiu Han, Caigan Du, Hao Wang
BACKGROUND: Endometrial regenerative cells (ERCs), a novel type of mesenchymal-like stem cell derived from menstrual blood, have been recently evaluated as an attractive candidate source in ulcerative colitis (UC); however, the mechanism is not fully understood. The present study was designed to investigate the effects of ERCs, especially on B-cell responses in UC. METHODS: In this study, colitis was induced by administering 3% dextran sodium sulfate (DSS) via free drinking water for 7 days to BALB/c mice...
May 22, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29784000/the-homing-of-bone-marrow-stem-cells-is-differentially-activated-in-ischemic-and-valvular-heart-diseases-and-influenced-by-beta-blockers
#9
Melissa Kristocheck, Lucinara D Dias, Carine Ghem, Bruna Eibel, Renato A K Kalil, Melissa M Markoski
BACKGROUND: Cell homing is the mechanism by which an injury releases signaling molecules that cause recruitment, proliferation, migration and differentiation of progenitor cells. Stromal derived factor-1 (SDF-1) and its receptor CXCR4 are key molecules involved in homing and little is known about their activation in cardiopathies. Here, we assessed the homing activation status of bone marrow cells (BMC) concerning the SDF-1 and CXCR4 expression in ischemic (IHD) and valvular (VHD) heart diseases...
May 21, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29783188/%C3%AE-pyrone-compounds-flavonoids-and-maltol-glucoside-derivatives-from-herniaria-glabra-l-collected-in-the-ternopil-region-of-the-ukraine
#10
Solomiia Kozachok, Łukasz Pecio, Joanna Kolodziejczyk-Czepas, Svitlana Marchyshyn, Pawel Nowak, Jarosław Mołdoch, Wiesław Oleszek
The phytochemical investigation of the whole plant extracts of Herniaria glabra L. (Caryophyllaceae) led to the identification and isolation of four known flavonoids, one known and three undescribed maltol derivatives, and benzyl β-gentiobioside. The structures were established by extensive 1D and 2D NMR spectroscopic analyses, as well as HRESIMS data. For the first time in Herniaria genus, as well as in Caryophylaceae family the presence of apiorutin {quercetin 3-O-[(D-apio-β-d-furanosyl-(1 → 2)-O-[-α-l-rhamnopyranosyl-(1 → 6)]-β-d-glucopyranoside]} and licoagroside B {maltol 3-O-[6-O-(3-hydroxy-3-methylglutaroyl)]-β-d-glucopyranoside} were revealed...
May 18, 2018: Phytochemistry
https://www.readbyqxmd.com/read/29783148/comparative-study-of-six-sequential-spectrophotometric-methods-for-quantification-and-separation-of-ribavirin-sofosbuvir-and-daclatasvir-an-application-on-laboratory-prepared-mixture-pharmaceutical-preparations-spiked-human-urine-spiked-human-plasma-and-dissolution
#11
Wafaa S Hassan, Manal S Elmasry, Heba M Elsayed, Dalia W Zidan
In accordance with International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) guidelines, six novel, simple and precise sequential spectrophotometric methods were developed and validated for the simultaneous analysis of Ribavirin (RIB), Sofosbuvir (SOF), and Daclatasvir (DAC) in their mixture without prior separation steps. These drugs are described as co-administered for treatment of Hepatitis C virus (HCV). HCV is the cause of hepatitis C and some cancers such as liver cancer (hepatocellular carcinoma) and lymphomas in humans...
May 18, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29782662/spoof-plasmonics-from-metamaterial-concept-to-topological-description
#12
REVIEW
Zhen Gao, Lin Wu, Fei Gao, Yu Luo, Baile Zhang
Advances in metamaterials have offered the opportunity of engineering electromagnetic properties beyond the limits of natural materials. A typical example is "spoof" surface plasmon polaritons (SPPs), which mimic features of SPPs without penetrating into metal, but only with periodic corrugations on metal surfaces. They hold considerable promise in device applications from microwaves to the far infrared, where real SPP modes do not exist. The original spoof SPP concept is derived from the description of corrugated surfaces by a metamaterial that hosts an effective plasma frequency...
May 21, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29782651/pharmacokinetic-and-metabolism-studies-of-bavachinin-through-ultra-high-performance-liquid-chromatography-coupled-with-electrospray-ionization-tandem-mass-spectrometry
#13
Jun Qian, Fan Xie, Yanhong Shi, Jinhang Li, Liuqiang Zhang, Yiming Li, Fujiang Guo, Rui Wang
Bavachinin (BVC), one of the main bioactive prenylated flavonoids derived from Psoralea corylifolia Linn, has a wide variety of pharmacological effects, such as antiangiogenic, antitumour, antiallergic, anti-inflammatory, and antibacterial activities, especially as a pan-peroxisome proliferator-activated receptors (PPARs) agonist. A rapid and sensitive method for quantifying BVC in rat plasma was developed and validated through ultra-high-performance liquid chromatography coupled with electrospray-ionization tandem mass spectrometry...
May 21, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29782406/population-pharmacokinetics-and-pharmacodynamics-of-dexmedetomidine-in-children-undergoing-ambulatory-surgery
#14
María-Gabriela Pérez-Guillé, Alejandra Toledo-López, Liliana Rivera-Espinosa, Radames Alemon-Medina, Chiharu Murata, Ismael Lares-Asseff, Juan Luis Chávez-Pacheco, Josefina Gómez-Garduño, Ana-Lilia Zamora Gutiérrez, Claudia Orozco-Galicia, Karina Ramírez-Morales, Gustavo Lugo-Goytia
BACKGROUND: Dexmedetomidine (DEX) is an α-2 adrenergic agonist with sedative and analgesic properties. Although not approved for pediatric use by the Food and Drug Administration, DEX is increasingly used in pediatric anesthesia and critical care. However, very limited information is available regarding the pharmacokinetics of DEX in children. The aim of this study was to investigate DEX pharmacokinetics and pharmacodynamics (PK-PD) in Mexican children 2-18 years of age who were undergoing outpatient surgical procedures...
May 17, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29780392/tumor-derived-apoptotic-vesicles-with-death-they-do-part
#15
REVIEW
Morad-Remy Muhsin-Sharafaldine, Alexander D McLellan
Tumor cells release lipid particles known as extracellular vesicles (EV) that contribute to cancer metastasis, to the immune response, and to thrombosis. When tumors are exposed to radiation or chemotherapy, apoptotic vesicles (ApoVs) are released in abundance as the plasma membrane delaminates from the cytoskeleton. Recent studies have suggested that ApoVs are distinct from the EVs released from living cells, such as exosomes or microvesicles. Depending on their treatment conditions, tumor-released ApoV have been suggested to either enhance or suppress anti-cancer immunity...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29780293/serial-changes-of-cytokines-in-children-with-cerebral-palsy-who-received-intravenous-granulocyte-colony-stimulating-factor-followed-by-autologous-mobilized-peripheral-blood-mononuclear-cells
#16
Hani Koh, Wee-Jin Rah, Yong-Joo Kim, Jin-Hwa Moon, Mi-Jung Kim, Young-Ho Lee
Background: This study was performed to assess serial cytokine changes and their clinical impact in children with cerebral palsy (CP) who received granulocyte-colony stimulating factor (G-CSF) followed by infusion of autologous mobilized peripheral blood mononuclear cells (mPBMCs). Methods: Peripheral blood (PB) samples were collected from 16 CP children at enrollment, and 1 month and 7 months after G-CSF infusion as well as at the end of the study. Cytokine levels were measured by enzyme-linked immunosorbent assays with plasma samples...
May 21, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29779470/ascites-derived-extracellular-micrornas-as-potential-biomarkers-for-ovarian-cancer
#17
Luděk Záveský, Eva Jandáková, Vít Weinberger, Luboš Minář, Veronika Hanzíková, Daniela Dušková, Lenka Záveská Drábková, Iveta Svobodová, Aleš Hořínek
Ovarian cancer as the most fatal gynecological malignancy is often manifested by excessive fluid accumulation known as ascites or effusion. Ascites-derived microRNAs (miRNAs) may be closely associated with ovarian cancer progression. However, our knowledge of their roles, altered expression, and clinical outcomes remained limited. In this study, large-scale expression profiling of 754 human miRNAs was performed using real-time quantitative polymerase chain reaction and 384-well TaqMan array human miRNA A and B cards to identify differentially expressed miRNAs between extracellular fraction of the ascitic fluid associated with high-grade serous ovarian carcinomas and control plasma...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29779350/-a-phase-%C3%A2-multi-center-clinical-trial-on-safety-and-efficacy-of-a-domestic-plasma-derived-factor-%C3%A2-for-the-treatment-of-patients-with-hemophilia-b
#18
W Liu, R F Fu, Y W Zhou, Y Chen, J Yin, Z Q Yu, L H Yang, M F Wang, H Bi, Z P Zhou, X S Zhang, J L Xia, R C Yang
Objective: To evaluate the efficacy and safety of a domestic human plasma derived coagulation Factor Ⅸ concentrate (pd-FⅨ) in patients with hemophilia B. Methods: The study was a multicenter, open-label and single-arm study. The efficacy of pd-F Ⅸ was evaluated by objective performance criteria. The doses of pd-FⅨ were calculated according to the bleeding symptom and disease severity. The infusion efficiency of pd-FⅨ and improvement of bleeding symptoms were measured at 30 minutes and (24±4) h after the first infusion, respectively...
May 14, 2018: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/29778532/non-alcoholic-fatty-liver-disease-insights-from-sphingolipidomics
#19
David J Montefusco, Jeremy C Allegood, Sarah Spiegel, L Ashley Cowart
Non-alcoholic fatty liver disease (NAFLD) is a major clinical concern and its treatment consumes abundant resources. While accumulation of lipids in hepatocytes initiates the disease, this in itself is not necessarily harmful; rather, initiation of inflammation and subsequent fibrosis and cirrhosis are critical steps in NAFLD pathology. Mechanisms linking lipid overload to downstream disease progression are not fully understood; however, bioactive lipid metabolism may underlie instigation of proinflammatory signaling...
May 17, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29778479/an-in-vivo-stable-isotope-based-approach-for-assessment-of-absorbed-amino-acids-from-individual-feed-ingredients-within-complete-diets
#20
K A Estes, R R White, P S Yoder, T Pilonero, H Schramm, H Lapierre, M D Hanigan
Accurate assessment of the nutritional content of feed ingredients is required for precise diet formulation. Characterizing ingredients in terms of absorption and digestibility of individual AA is challenging, and this information often relies on indirect methods. The purpose of this research was to evaluate an in vivo stable isotope-based method of determining plasma entry rates of individual AA from feather meal (FM), blood meal (BM), and a rumen-protected AA (RPMet). Abomasal infusions of unprotected Ile, Leu, Met, and sodium caseinate were used as control treatments to assess technique reliability and accuracy...
May 16, 2018: Journal of Dairy Science
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