keyword
https://read.qxmd.com/read/38537134/nk-cell-elicited-gasdermin-d-dependent-hepatocyte-pyroptosis-induces-neutrophil-extracellular-traps-that-facilitates-hbv-related-acute-on-chronic-liver-failure
#1
JOURNAL ARTICLE
Qiang Zhao, Dong-Ping Chen, Hua-Di Chen, Ying-Zhe Wang, Wei Shi, Yi-Tong Lu, Yi-Zheng Ren, Yuan-Kai Wu, Yi-Hua Pang, Hong Deng, Xiaoshun He, Dong-Ming Kuang, Zhi-Yong Guo
BACKGROUND AIMS: Hepatitis B virus (HBV) infection is a major etiology of acute-on-chronic liver failure (ACLF). At present, the pattern and regulation of hepatocyte death during HBV-ACLF progression are still undefined. Evaluating the mode of cell death and its inducers will provide new insights for developing therapeutic strategies targeting cell death. In this study, we aimed to elucidate whether and how immune landscapes trigger hepatocyte death and lead to the progression of HBV-related ACLF...
March 27, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38536597/exosomal-encapsulation-of-mir-3198-promotes-proliferation-and-migration-of-trophoblasts-in-preeclampsia
#2
JOURNAL ARTICLE
Yuchen Li, Yanling Yu, Dejun Li, Lei Li
PURPOSE: Preeclampsia (PE) is a vascular remodeling disorder cloesly linked to trophoblast dysfunction, involving defects in their proliferation, migration, and apoptosis. Maternal exosomal microRNAs (miRNAs) have been reported to play pivotal roles in the development of PE. However, the mechanism underlying the role of maternal exosomes in trophoblast dysfunction regarding the development of PE is poorly understood. METHODS: Plasma exosomes from maternal peripheral blood were collected from pregnant women with PE and from those with normal pregnancy...
March 27, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38536533/detection-of-circulatory-e-granulosus-derived-cell-free-dna-in-the-plasma-and-urine-of-human-cystic-echinococcosis-using-an-in-house-pcr-a-potential-promising-diagnostic-biomarker
#3
JOURNAL ARTICLE
Bentolhoda Habibi, Shirzad Gholami, Abouzar Bagheri, Mahdi Fakhar, Mahdi Torabi, Rabeeh Tabaripour, Alimohammad Moradi
BACKGROUND: The diagnostic tool for identifying cystic echinococcosis (CE) patients at an early stage is currently lacking. However, circulatory cell-free DNA (cfDNA) has shown potential as a biomarker for parasitic infections and could be used for diagnosing CE. RESEARCH DESIGN AND METHODS: The plasma and urine samples were collected from 39 patients with confirmed CE through imaging and histopathological techniques. All plasma samples were tested for anti-echinococcal antibodies using a commercial ELISA test...
March 27, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38534738/effects-of-blood-derived-products-on-cellular-senescence-and-inflammatory-response-a-study-on-skin-rejuvenation
#4
JOURNAL ARTICLE
Harald Kühnel, Markus Pasztorek, Olga Kuten-Pella, Karina Kramer, Christoph Bauer, Zsombor Lacza, Stefan Nehrer
Blood-derived products, such as citrate platelet-rich plasma (CPRP) and hyperacute serum (HAS), are recognized for their rich growth factor content. When human dermal fibroblast (HDF) cells are exposed to combined mitogenic and DNA-damaging stimuli, it can lead to an increased burden of senescent cells and a modified senescence-associated secretory phenotype. In this study, the senescent state was comprehensively assessed through various methods, including phosphorylated histone H2AX (γH2AX) staining, p21 and p16 q-PCR, p21-western blot, growth curves, and senescence-associated ß-galactosidase staining...
February 28, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534322/blood-markers-show-neural-consequences-of-longcovid-19
#5
JOURNAL ARTICLE
Norina Tang, Tatsuo Kido, Jian Shi, Erin McCafferty, Judith M Ford, Kaitlyn Dal Bon, Lynn Pulliam
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) persists throughout the world with over 65 million registered cases of survivors with post-COVID-19 sequelae, also known as LongCOVID-19 (LongC). LongC survivors exhibit various symptoms that span multiple organ systems, including the nervous system. To search for neurological markers of LongC, we investigated the soluble biomolecules present in the plasma and the proteins associated with plasma neuronal-enriched extracellular vesicles (nEVs) in 33 LongC patients with neurological impairment (nLongC), 12 COVID-19 survivors without any LongC symptoms (Cov), and 28 pre-COVID-19 healthy controls (HC)...
March 8, 2024: Cells
https://read.qxmd.com/read/38534319/exploring-the-potential-role-of-metabolomics-in-copd-a-concise-review
#6
REVIEW
Claudio Tirelli, Sabrina Mira, Luca Alessandro Belmonte, Federica De Filippi, Mauro De Grassi, Marta Italia, Sara Maggioni, Gabriele Guido, Michele Mondoni, Giorgio Walter Canonica, Stefano Centanni
Chronic Obstructive Pulmonary Disease (COPD) is a pathological condition of the respiratory system characterized by chronic airflow obstruction, associated with changes in the lung parenchyma (pulmonary emphysema), bronchi (chronic bronchitis) and bronchioles (small airways disease). In the last years, the importance of phenotyping and endotyping COPD patients has strongly emerged. Metabolomics refers to the study of metabolites (both intermediate or final products) and their biological processes in biomatrices...
March 7, 2024: Cells
https://read.qxmd.com/read/38533731/poacic-acid-a-plant-derived-stilbenoid-augments-cell-wall-chitin-production-but-its-antifungal-activity-is-hindered-by-this-polysaccharide-and-by-fungal-essential-metals
#7
JOURNAL ARTICLE
Adi Yona, Micha Fridman
Climate and environmental changes have modified the habitats of fungal pathogens, inflicting devastating effects on livestock and crop production. Additionally, drug-resistant fungi are increasing worldwide, driving the urgent need to identify new molecular scaffolds for the development of antifungal agents for humans, animals, and plants. Poacic acid (PA), a plant-derived stilbenoid, was recently discovered to be a novel molecular scaffold that inhibits the growth of several fungi. Its antifungal activity has been associated with perturbation of the production/assembly of the fungal cell wall β-1,3-glucan, but its mode of action is not resolved...
March 27, 2024: Biochemistry
https://read.qxmd.com/read/38533577/plasma-neurofilament-light-chain-is-increased-in-niemann-pick-type-c-but-glial-fibrillary-acidic-protein-remains-normal
#8
JOURNAL ARTICLE
Dhamidhu Eratne, Courtney Lewis, Wendy Kelso, Samantha Loi, Wei-Hsuan Michelle Chiu, Kaj Blennow, Henrik Zetterberg, Alexander F Santillo, Dennis Velakoulis, Mark Walterfang
OBJECTIVE: Niemann-Pick Type C (NPC) is a genetic neurodegenerative lysosomal storage disorder commonly associated with psychiatric symptoms and delays to accurate diagnosis and treatment. This study investigated biomarker levels and diagnostic utility of plasma neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) in NPC compared to healthy controls. METHODS: Patients with NPC were recruited from a specialist assessment and management service...
March 27, 2024: Acta Neuropsychiatrica
https://read.qxmd.com/read/38532793/editorial-poultry-feeding-nutrition-and-quality-in-the-post-antibiotic-era
#9
EDITORIAL
Abdel-Moneim Eid Abdel-Moneim, Ilaria Biasato, Noura M Mesalam, Abdelrazeq M Shehata
No abstract text is available yet for this article.
2024: Frontiers in Veterinary Science
https://read.qxmd.com/read/38532026/macrophage-mannose-receptor-cd206-targeting-of-fluoride-18-labeled-mannosylated-dextran-a-validation-study-in-mice
#10
JOURNAL ARTICLE
Putri Andriana, Ruth Fair-Mäkelä, Heidi Liljenbäck, Salli Kärnä, Imran Iqbal, Konstantina Makrypidi, Johan Rajander, Ioannis Pirmettis, Xiang-Guo Li, Sirpa Jalkanen, Antti Saraste, Marko Salmi, Anne Roivainen
PURPOSE: Aluminum fluoride-18-labeled 1,4,7-triazacyclononane-1,4,7-triacetic acid-conjugated mannosylated dextran derivative (Al[18 F]F-NOTA-D10CM) is a new tracer for PET imaging. We report here on in vitro and in vivo validation of the tracer's ability to target the macrophage mannose receptor CD206. METHODS: First, the uptake of intravenously (i.v.) administered Al[18 F]F-NOTA-D10CM was compared between wild-type (WT) and CD206-/- knockout (KO) mice. C57BL/6N mice were injected with complete Freund's adjuvant (CFA) in the left hind leg and the uptake of Al[18 F]F-NOTA-D10CM after i...
March 27, 2024: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38532020/contemporary-pharmacological-treatment-and-management-of-heart-failure
#11
REVIEW
Biykem Bozkurt
The prevention and treatment strategies for heart failure (HF) have evolved in the past two decades. The stages of HF have been redefined, with recognition of the pre-HF state, which encompasses asymptomatic patients who have developed either structural or functional cardiac abnormalities or have elevated plasma levels of natriuretic peptides or cardiac troponin. The first-line treatment of patients with HF with reduced ejection fraction includes foundational therapies with angiotensin receptor-neprilysin inhibitors, angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, β-blockers, mineralocorticoid receptor antagonists, sodium-glucose cotransporter 2 (SGLT2) inhibitors and diuretics...
March 26, 2024: Nature Reviews. Cardiology
https://read.qxmd.com/read/38529947/a-novel-machine-learning-algorithm-selects-proteome-signature-to-specifically-identify-cancer-exosomes
#12
JOURNAL ARTICLE
Bingrui Li, Fernanda G Kugeratski, Raghu Kalluri
Non-invasive early cancer diagnosis remains challenging due to the low sensitivity and specificity of current diagnostic approaches. Exosomes are membrane-bound nanovesicles secreted by all cells that contain DNA, RNA, and proteins that are representative of the parent cells. This property, along with the abundance of exosomes in biological fluids makes them compelling candidates as biomarkers. However, a rapid and flexible exosome-based diagnostic method to distinguish human cancers across cancer types in diverse biological fluids is yet to be defined...
March 26, 2024: ELife
https://read.qxmd.com/read/38529793/transdermal-nicotine-patch-increases-the-number-and-function-of-endothelial-progenitor-cells-in-young-healthy-nonsmokers-without-adverse-hemodynamic-effects
#13
JOURNAL ARTICLE
Yen-Yu Liu, Ting-Yi Tien, Chung-Lieh Hung, Yih-Jer Wu, Cheng-Huang Su, Hung-I Yeh
Transdermal nicotine patches (TNPs), administering nicotine into the bloodstream through skin, have been widely used as nicotine replacement therapy, and exposure to nicotine can be detected by measurement of plasma cotinine concentration. In animal studies, nicotine treatment could increase the number of endothelial progenitor cells (EPCs), but the effect of TNPs on circulating EPCs and their activity in humans remained unclear. This study aimed to explore the influence of TNPs on circulating EPCs with surface markers of CD34, CD133, and/or KDR, and colony-forming function plus migration activity of early EPCs derived from cultured peripheral blood mononuclear cells before and after TNP treatments in young healthy nonsmokers...
March 26, 2024: Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/38529586/characterization-of-nanoparticles-in-mixtures-by-taylor-dispersion-analysis-hyphenated-to-inductively-coupled-plasma-mass-spectrometry
#14
JOURNAL ARTICLE
Daniel Baron, Tomáš Pluháček, Jan Petr
A novel methodology for investigating the behavior of nanoparticles in their mixtures in aqueous high-ionic strength conditions is presented in this work. Our approach utilizes Taylor dispersion analysis in capillaries connected to inductively coupled plasma mass spectrometry (ICP-MS) to probe metal-derived nanoparticles. This methodology simultaneously distinguishes between different kinds of nanoparticles and accurately determines their essential parameters, such as hydrodynamic size, diffusion coefficient, and elemental composition...
March 26, 2024: Analytical Chemistry
https://read.qxmd.com/read/38528511/delivering-synaptic-protein-mrnas-via-extracellular-vesicles-ameliorates-cognitive-impairment-in-a-mouse-model-of-alzheimer-s-disease
#15
JOURNAL ARTICLE
Huimin Cai, Yana Pang, Ziye Ren, Xiaofeng Fu, Longfei Jia
BACKGROUND: Synaptic dysfunction with reduced synaptic protein levels is a core feature of Alzheimer's disease (AD). Synaptic proteins play a central role in memory processing, learning, and AD pathogenesis. Evidence suggests that synaptic proteins in plasma neuronal-derived extracellular vesicles (EVs) are reduced in patients with AD. However, it remains unclear whether levels of synaptic proteins in EVs are associated with hippocampal atrophy of AD and whether upregulating the expression of these synaptic proteins has a beneficial effect on AD...
March 25, 2024: BMC Medicine
https://read.qxmd.com/read/38528508/triglyceride-glucose-index-in-early-pregnancy-predicts-the-risk-of-gestational-diabetes-a-prospective-cohort-study
#16
JOURNAL ARTICLE
Yufeng Guo, Junwen Lu, Mailiman Bahani, Guifeng Ding, Lei Wang, Yuxia Zhang, Huanmei Zhang, Chengyao Liu, Lijun Zhou, Xiaolan Liu, Fangshen Li, Xiaoli Wang, Hong Ding
OBJECTIVE: This study aimed to investigate the association between the triglyceride-glucose (TyG) index in early pregnancy and the development of gestational diabetes mellitus (GDM) in the second trimester. The primary objectives were to evaluate the predictive potential of the TyG index for GDM, determine the optimal threshold value of the TyG index for GDM assessment, and compare the predictive performance of the TyG index alone versus its combination with maternal age and pre-pregnancy body mass index on GDM...
March 25, 2024: Lipids in Health and Disease
https://read.qxmd.com/read/38528176/a-combination-nutritional-supplement-reduces-dna-methylation-age-only-in-older-adults-with-a-raised-epigenetic-age
#17
JOURNAL ARTICLE
Kirsty C McGee, Jack Sullivan, Jon Hazeldine, Lisa J Schmunk, Daniel E Martin-Herranz, Thomas Jackson, Janet M Lord
An increase in systemic inflammation (inflammaging) is one of the hallmarks of aging. Epigenetic (DNA methylation) clocks can quantify the degree of biological aging and this can be reversed by lifestyle and pharmacological intervention. We aimed to investigate whether a multi-component nutritional supplement could reduce systemic inflammation and epigenetic age in healthy older adults.We recruited 80 healthy older participants (mean age ± SD: 71.85 ± 6.23; males = 31, females = 49)...
March 26, 2024: GeroScience
https://read.qxmd.com/read/38525222/the-activity-of-monocyte-derived-macrophages-after-stimulation-with-platelet-rich-and-platelet-poor-concentrates-study-on-an-ovine-model-of-insertion-of-a-tibial-implant-coated-with-silicon-doped-diamond-like-carbon
#18
JOURNAL ARTICLE
Bartłomiej Szymczak, Andrzej Junkuszew, Krzysztof Patkowski, Tomasz Szponder, Dominika Nguyen Ngoc, Beata Drzewiecka, Aleksandra Sobczyńska-Rak, Joanna Wessely-Szponder
INTRODUCTION: Macrophages are crucial immune cells that play a role in tissue repair and can exhibit pro- or anti-inflammatory behaviour based on environmental stimulation. Their functional phenotype can be affected by platelet-derived products as determined by those products' composition. When the inflammatory response caused by implantation is excessive, it can lead to rejection of the implant. Therefore, a thorough evaluation of implant haemocompatibility is necessary to minimise undesirable consequences...
March 2024: Journal of Veterinary Research
https://read.qxmd.com/read/38522838/clinical-implementation-of-a-non-invasive-multi-analyte-ddpcr-test-to-screen-for-androgen-receptor-alterations
#19
JOURNAL ARTICLE
Regina Stitz, Franz Stoiber, Renè Silye, Georgios Vlachos, Silvia Andaloro, Elisabeth Rebhan, Michael Dunzinger, Franz Pühringer, Caroline Gallo, Amin El-Heliebi, Ellen Heitzer, Cornelia Hauser-Kronberger
Recent studies have shown that alterations of the androgen receptor (AR) are associated with resistance to AR-directed therapy in prostate cancer. Thus, it is crucial to develop robust detection methods for AR alterations as predictive biomarkers to enable applicability in clinical practice. We designed and validated five multiplex droplet digital PCR (ddPCR) assays for reliable detection of 12 AR targets including AR amplification, AR-V7 and 10 AR hotspot mutations as well as AR and KLK3 gene expression from plasma derived cell-free (cf)DNA and cfRNA...
March 22, 2024: Journal of Molecular Diagnostics: JMD
https://read.qxmd.com/read/38522605/changes-in-cargoes-of-platelet-derived-extracellular-vesicles-heterogeneous-subpopulations-induced-by-pm-0-1-undisclosed-cardiovascular-injury-communication-mechanism
#20
JOURNAL ARTICLE
Zhen Mao, Yingting Wu, Ling Kong, Lihong Zhou, Xiaodan Zhang, Aobo Geng, Jin Cai, Hong Yang, Huang Peili
Epidemiological evidence has indicated a closely link between PM0.1 exposure and the incidence rate of cardiovascular diseases. This study explores the underlying communication roles of platelet-derived extracellular vesicles (PEVs) heterogeneous subpopulations in cardiovascular injury. PEVs and PMEVs which were extracted from platelet-rich plasma (PRP) un-exposure or exposure to PM0.1 were extracted by TIM4 affinity beads. By optimizing separation conditions, replacing pipelines, and resetting injection procedures, Asymmetric flow field-flow fractionation (AF4) was employed to separate, purify, characterize, and enrich PEVs and PMEVs heterogeneous subpopulations (small PEVs, PEVs-S/PMEVs-S: <100 nm; medium PEVs, PEVs-M/PMEVs-M: 100-200 nm; and large PEVs, PEVs-L/PMEVs-L: >200 nm)...
March 22, 2024: Environmental Pollution
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