Putri Andriana, Ruth Fair-Mäkelä, Heidi Liljenbäck, Salli Kärnä, Imran Iqbal, Konstantina Makrypidi, Johan Rajander, Ioannis Pirmettis, Xiang-Guo Li, Sirpa Jalkanen, Antti Saraste, Marko Salmi, Anne Roivainen
PURPOSE: Aluminum fluoride-18-labeled 1,4,7-triazacyclononane-1,4,7-triacetic acid-conjugated mannosylated dextran derivative (Al[18 F]F-NOTA-D10CM) is a new tracer for PET imaging. We report here on in vitro and in vivo validation of the tracer's ability to target the macrophage mannose receptor CD206. METHODS: First, the uptake of intravenously (i.v.) administered Al[18 F]F-NOTA-D10CM was compared between wild-type (WT) and CD206-/- knockout (KO) mice. C57BL/6N mice were injected with complete Freund's adjuvant (CFA) in the left hind leg and the uptake of Al[18 F]F-NOTA-D10CM after i...
March 27, 2024: European Journal of Nuclear Medicine and Molecular Imaging